locus-tag class description A4G13_RS00010 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) A4G13_RS00015 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) A4G13_RS00020 ENOG4105D01 (LipO)protein A4G13_RS00025 ENOG4108UMI ABC transporter, permease A4G13_RS00030 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A4G13_RS00035 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase A4G13_RS00075 ENOG4105ERG peptidase m48, ste24p A4G13_RS00080 ENOG4106WTF Glycosyl transferase, family 2 A4G13_RS00085 ENOG4105M5K heptosyltransferase A4G13_RS00090 ENOG4105K5M 30s ribosomal protein S16 A4G13_RS00095 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) A4G13_RS00100 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A4G13_RS00105 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) A4G13_RS00120 ENOG4105W1T Glycosyl Transferase A4G13_RS00125 ENOG4105X1N Glycosyl transferase family 8 A4G13_RS00130 ENOG4105VFB Binds the 23S rRNA (By similarity) A4G13_RS00135 ENOG4105C25 Primosomal protein n' A4G13_RS00140 ENOG41063M6 Cell Division Protein A4G13_RS00145 ENOG4105Y7M Transcriptional regulator, TetR family A4G13_RS00150 ENOG410624X efflux transporter, rnd family, mfp subunit A4G13_RS00155 ENOG4105BZS acriflavin resistance protein A4G13_RS00165 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) A4G13_RS00170 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A4G13_RS00175 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) A4G13_RS00180 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A4G13_RS00185 ENOG4108S9F abc transporter, atp-binding protein A4G13_RS00195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A4G13_RS00200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A4G13_RS00205 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein A4G13_RS00210 ENOG4107Y1Y Methyltransferase A4G13_RS00215 ENOG4105W1Y Transcriptional regulator A4G13_RS00220 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) A4G13_RS00225 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) A4G13_RS00230 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) A4G13_RS00235 ENOG4105K9Q Binds to the 23S rRNA (By similarity) A4G13_RS00240 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A4G13_RS00245 ENOG4105C2N RNA methyltransferase TrmH family group 3 A4G13_RS00250 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase A4G13_RS00265 ENOG4105E07 UPF0149 protein A4G13_RS00270 ENOG4107RAQ aminopeptidase A4G13_RS00275 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A4G13_RS00280 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A4G13_RS00285 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) A4G13_RS00290 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) A4G13_RS00300 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) A4G13_RS00305 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A4G13_RS00310 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A4G13_RS00315 ENOG4105CWM branched-chain amino acid transport system II carrier protein A4G13_RS00320 ENOG4108ST3 glycosyltransferase A4G13_RS00345 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A4G13_RS00355 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) A4G13_RS00360 ENOG4105RT1 May be involved in cell division (By similarity) A4G13_RS00365 ENOG4105C1J atp-dependent rna helicase A4G13_RS00370 ENOG4105CHH sulfate transporter A4G13_RS00380 ENOG4105EX9 Membrane A4G13_RS00385 ENOG4105D2S major facilitator superfamily A4G13_RS00390 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A4G13_RS00395 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) A4G13_RS00400 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A4G13_RS00405 ENOG4105D52 delta-aminolevulinic acid dehydratase A4G13_RS00415 ENOG4108UBT opacity-associated protein A4G13_RS00420 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein A4G13_RS00425 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A4G13_RS00430 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) A4G13_RS00435 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase A4G13_RS00440 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) A4G13_RS00445 ENOG4108UQV Membrane A4G13_RS00450 ENOG41067XB TonB family A4G13_RS00455 ENOG4105M15 transport protein ExbD A4G13_RS00460 ENOG4105M8K biopolymer transport protein A4G13_RS00465 ENOG4107ENK receptor A4G13_RS00470 ENOG4108JU6 CBS domain protein A4G13_RS00475 ENOG4106KVJ cytochrome C assembly protein A4G13_RS00480 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY A4G13_RS00485 ENOG4105C09 Bile acid A4G13_RS00490 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant A4G13_RS00495 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A4G13_RS00505 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A4G13_RS00515 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A4G13_RS00530 ENOG4105CTX dehydratase A4G13_RS00535 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) A4G13_RS00540 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A4G13_RS00545 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) A4G13_RS00555 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) A4G13_RS00560 ENOG4107YCY Transcriptional regulator A4G13_RS00570 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A4G13_RS00575 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter A4G13_RS00580 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A4G13_RS00585 ENOG4105DMW Dehydrogenase reductase A4G13_RS00590 ENOG4105D2H Uronic isomerase A4G13_RS00595 ENOG4107SS6 2-dehydro-3-deoxygluconokinase A4G13_RS00600 ENOG4108UHU Aldolase A4G13_RS00605 ENOG4108R1E Serine threonine protein phosphatase 1 A4G13_RS00610 ENOG4108IJ7 Glycine betaine A4G13_RS00615 ENOG4108HQS Glycine betaine A4G13_RS00620 ENOG4105GIJ Glycine betaine A4G13_RS00625 ENOG4105D5Q Arginine ornithine antiporter A4G13_RS00635 ENOG4105C3G gtp-binding protein A4G13_RS00640 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A4G13_RS00650 ENOG4105VDB UPF0125 protein A4G13_RS00655 ENOG4105EZE Cupin 4 family protein A4G13_RS00665 ENOG4105ZU8 porin-like protein H A4G13_RS00670 ENOG4105J4Q Transcriptional regulator A4G13_RS00675 ENOG4105CHR reductase A4G13_RS00685 ENOG4107SS6 2-dehydro-3-deoxygluconokinase A4G13_RS00690 ENOG4108UHU Aldolase A4G13_RS00695 ENOG4105M5J Cupin 2, conserved barrel domain protein A4G13_RS00700 ENOG4105HHA aminodeoxychorismate lyase A4G13_RS00705 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) A4G13_RS00710 ENOG4107QRG dna polymerase iii A4G13_RS00715 ENOG4105F8V Hydrolase, tatD family A4G13_RS00720 ENOG4105RX8 Protein of unknown function (DUF1523) A4G13_RS00725 ENOG4105C37 (CBS) domain A4G13_RS00730 ENOG4105C0B DNA polymerase III (alpha subunit) A4G13_RS00740 ENOG4105UNS Pfam:DUF419 A4G13_RS00745 ENOG4105FR1 rard protein A4G13_RS00750 ENOG4105E98 transcriptional regulator DeoR family A4G13_RS00755 ENOG4108MGF sugar kinase A4G13_RS00760 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A4G13_RS00765 ENOG4105D2M Aldolase A4G13_RS00770 ENOG4105CJQ hydrolase, family 31 A4G13_RS00775 ENOG4107QKS N-acylglucosamine 2-epimerase A4G13_RS00780 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) A4G13_RS00795 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A4G13_RS00810 ENOG4105F38 ABC transporter, permease A4G13_RS00820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A4G13_RS00825 ENOG4108UUM single-stranded DNA-binding protein A4G13_RS00830 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A4G13_RS00835 ENOG4105CUW cytochrome C-TYPE protein A4G13_RS00840 ENOG4107QY8 reductase A4G13_RS00845 ENOG4105DFF Rod shape-determining protein mreb A4G13_RS00850 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) A4G13_RS00860 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A4G13_RS00865 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A4G13_RS00870 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A4G13_RS00880 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) A4G13_RS00885 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) A4G13_RS00890 ENOG41060IM Heme exporter protein A4G13_RS00895 ENOG4105X3C heme exporter protein A4G13_RS00900 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) A4G13_RS00905 ENOG4105DA4 cytochrome c-type biogenesis protein A4G13_RS00910 ENOG4107QX9 Thiol disulfide interChange protein A4G13_RS00915 ENOG4108M1T Cytochrome c-type biogenesis protein A4G13_RS00920 ENOG4108M1T Cytochrome c-type biogenesis protein A4G13_RS00925 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase A4G13_RS00940 ENOG4105EIP mannose-6-phosphate isomerase A4G13_RS00945 ENOG4108NK4 UPF0266 membrane protein A4G13_RS00950 ENOG4105F3R pts system mannose fructose sorbose family iid A4G13_RS00955 ENOG4105ETZ PTS System A4G13_RS00960 ENOG4105DAS pts system A4G13_RS00965 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA A4G13_RS00970 ENOG4105E7A Glutamine amidotransferase A4G13_RS00975 ENOG4105C8N cysteinyl-tRNA synthetase A4G13_RS00985 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) A4G13_RS00990 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) A4G13_RS00995 ENOG4105EYA deoxyribonuclease A4G13_RS01000 ENOG4105CXB phosphoribosylaminoimidazole synthetase A4G13_RS01005 ENOG4108V3E phosphoribosylglycinamide formyltransferase A4G13_RS01010 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) A4G13_RS01015 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) A4G13_RS01020 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A4G13_RS01025 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) A4G13_RS01030 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) A4G13_RS01035 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase A4G13_RS01040 ENOG4105EE5 Membrane protein terC A4G13_RS01050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A4G13_RS01060 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator A4G13_RS01065 ENOG4108HWV )-transporter A4G13_RS01070 ENOG4105C2J ABC transporter A4G13_RS01075 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator A4G13_RS01080 ENOG41060NJ transcriptional regulator A4G13_RS01085 ENOG4105F0Z galactose-1-phosphate uridylyltransferase A4G13_RS01090 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) A4G13_RS01095 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) A4G13_RS01100 ENOG4108JU5 Magnesium and cobalt efflux protein A4G13_RS01105 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) A4G13_RS01110 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) A4G13_RS01115 ENOG4107VDP teichoic acid biosynthesis A4G13_RS01120 ENOG4107VDP teichoic acid biosynthesis A4G13_RS01125 ENOG4105MFV ABC-2 type transporter A4G13_RS01135 ENOG4107QRS glycosyltransferase group 2 family protein A4G13_RS01155 ENOG4105D3Q Sugar transferase A4G13_RS01160 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A4G13_RS01165 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) A4G13_RS01170 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP A4G13_RS01175 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction A4G13_RS01180 ENOG4106032 Glutathionylspermidine synthase A4G13_RS01185 ENOG4105KUZ arsenate reductase A4G13_RS01190 ENOG4108UK5 Transposase A4G13_RS01195 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) A4G13_RS01205 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) A4G13_RS01210 ENOG4105DWF phosphomethylpyrimidine kinase A4G13_RS01220 ENOG4105E3J oxidoreductase A4G13_RS01225 ENOG4105N42 UPF0307 protein A4G13_RS01230 ENOG4105CMS peptidase U62, modulator of DNA gyrase A4G13_RS01235 ENOG4108UGV hypoxanthine phosphoribosyltransferase A4G13_RS01245 ENOG4105C6Z Gluconate A4G13_RS01250 ENOG4105CV8 reductase A4G13_RS01255 ENOG4105C6Z Gluconate A4G13_RS01260 ENOG4105EQX glucarate dehydratase A4G13_RS01265 ENOG4105CNV Aldolase A4G13_RS01270 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A4G13_RS01275 ENOG4105BZW Glycerate kinase A4G13_RS01280 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR A4G13_RS01285 ENOG4105CTX dehydratase A4G13_RS01310 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A4G13_RS01315 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) A4G13_RS01330 ENOG4105D3Y Na H antiporter A4G13_RS01335 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) A4G13_RS01340 ENOG4108UYE Lactoylglutathione lyase A4G13_RS01345 ENOG4106PMH Extracellular solute-binding protein family 3 A4G13_RS01350 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) A4G13_RS01355 ENOG4105C9M aspartyl-trna synthetase A4G13_RS01360 ENOG4108TIT dATP pyrophosphohydrolase A4G13_RS01365 ENOG4105CDY transcriptional regulatory protein A4G13_RS01370 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) A4G13_RS01375 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) A4G13_RS01380 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) A4G13_RS01390 ENOG4105C4M (Ubiquinol oxidase) subunit I A4G13_RS01395 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A4G13_RS01405 ENOG4105KJB cyd operon protein YbgE A4G13_RS01410 ENOG4107YD3 Thioesterase A4G13_RS01415 ENOG4105E02 MotA TolQ exbB proton channel A4G13_RS01430 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) A4G13_RS01435 ENOG4105KCK Peptidoglycan-associated lipoprotein A4G13_RS01475 ENOG4105DSY exodeoxyribonuclease V, gamma A4G13_RS01490 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A4G13_RS01500 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) A4G13_RS01505 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) A4G13_RS01510 ENOG4105K9H YciI-like protein A4G13_RS01515 ENOG4105NAU thioesterase Superfamily protein A4G13_RS01520 ENOG4107835 probably involved in intracellular septation (By similarity) A4G13_RS01530 ENOG4105EIF outer membrane protein W A4G13_RS01535 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) A4G13_RS01540 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A4G13_RS01545 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A4G13_RS01550 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A4G13_RS01555 ENOG4105E55 glycerol-3-phosphate acyltransferase A4G13_RS01560 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A4G13_RS01565 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) A4G13_RS01570 ENOG4105EUR Domain-Containing protein A4G13_RS01570 ENOG4105EUR Domain-Containing protein A4G13_RS01575 ENOG4105CNT hydrolase family 2 A4G13_RS01580 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) A4G13_RS01585 ENOG4107QR9 Iron-sulfur cluster binding protein A4G13_RS01590 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A4G13_RS01595 ENOG4105DAA L-lactate A4G13_RS01600 ENOG4107QZM n-acetylglutamate synthase A4G13_RS01605 ENOG41090BQ Glutaredoxin A4G13_RS01610 ENOG4108DBC nitroreductase A4G13_RS01615 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) A4G13_RS01620 ENOG4105D0Y UPF0227 protein A4G13_RS01625 ENOG4105RHG A4G13_RS01630 ENOG4105C9Q fumarate hydratase class II A4G13_RS01635 ENOG4106K28 UPF0283 membrane protein A4G13_RS01640 ENOG4108JU8 Transcriptional regulator A4G13_RS01645 ENOG4105DZ2 Transcriptional regulator A4G13_RS01650 ENOG4108UMN azlc family A4G13_RS01655 ENOG4105KMT branched-chain amino acid A4G13_RS01660 ENOG4105BZG amino acid carrier protein A4G13_RS01665 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) A4G13_RS01670 ENOG4105TWJ Domain of unknown function (DUF1919) A4G13_RS01675 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain A4G13_RS01680 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A4G13_RS01690 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) A4G13_RS01695 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase A4G13_RS01700 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) A4G13_RS01705 ENOG4105CK7 Sodium proline symporter A4G13_RS01710 ENOG4105C03 ribonuclease A4G13_RS01715 ENOG4105D1U peptidase U62 modulator of DNA gyrase A4G13_RS01720 ENOG4105C8Y Acetylornithine aminotransferase A4G13_RS01725 ENOG4105C5Y PTS System A4G13_RS01735 ENOG4105CFP Peptidase U32 A4G13_RS01740 ENOG4105SYT Methylenetetrahydrofolate reductase A4G13_RS01745 ENOG4105FAV ABC, transporter A4G13_RS01750 ENOG4105FDK ABC transporter A4G13_RS01755 ENOG4105DR5 peptidase A4G13_RS01760 ENOG4105DHS permease protein A4G13_RS01765 ENOG4105CM4 permease protein A4G13_RS01770 ENOG4108IPW abc transporter atp-binding protein A4G13_RS01780 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A4G13_RS01785 ENOG4105EYM Major Facilitator superfamily A4G13_RS01790 ENOG4105CMR udp-glucose 4-epimerase A4G13_RS01795 ENOG4105KAF membrAne A4G13_RS01805 ENOG4105C7N Xanthine uracil vitamin C permease A4G13_RS01815 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A4G13_RS01820 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) A4G13_RS01830 ENOG4105CNT hydrolase family 2 A4G13_RS01835 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) A4G13_RS01840 ENOG4106NDP Transcriptional regulator A4G13_RS01845 ENOG4107RUE extracellular solute-binding protein family 1 A4G13_RS01850 ENOG4105D38 putrescine abc transporter A4G13_RS01855 ENOG4105F38 ABC transporter, permease A4G13_RS01860 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A4G13_RS01865 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A4G13_RS01870 ENOG4105DY2 Paraquat-inducible protein b A4G13_RS01875 ENOG4105H2K paraquat-inducible protein a A4G13_RS01880 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) A4G13_RS01885 ENOG4105CN1 protease A4G13_RS01890 ENOG4105DIT ErfK YbiS YcfS YnhG family protein A4G13_RS01895 ENOG4105EAQ (twin-arginine translocation) pathway signal A4G13_RS01900 ENOG4105C5X domain protein A4G13_RS01910 ENOG4105DY8 decarboxylase A4G13_RS01915 ENOG4108JPW Aminotransferase A4G13_RS01935 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) A4G13_RS01940 ENOG4105DKW ABC transporter A4G13_RS01945 ENOG4107QX8 SPFH domain, Band 7 family protein A4G13_RS01955 ENOG4105DYS nad(p)h dehydrogenase (quinone) A4G13_RS01960 ENOG4107XHZ cytoplasmic chaperone TorD family protein A4G13_RS01965 ENOG410901E Membrane A4G13_RS01970 ENOG4108Z5K methylglyoxal synthase A4G13_RS01975 ENOG4105C5H ABC transporter A4G13_RS02020 ENOG4108K4B hydrolase A4G13_RS02030 ENOG4108Q67 UPF0319 protein A4G13_RS02035 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 A4G13_RS02040 ENOG4108Z0T Part of a sulfur-relay system (By similarity) A4G13_RS02045 ENOG4108MN8 Membrane A4G13_RS02055 ENOG41061WM D-Alanyl-D-Alanine A4G13_RS02065 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein A4G13_RS02070 ENOG4108EU3 peptide transport system, permease A4G13_RS02080 ENOG4108EVY peptide transport periplasmic protein A4G13_RS02085 ENOG4105CM6 amino acid regulated cytosolic protein A4G13_RS02090 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A4G13_RS02095 ENOG41090R7 Ferric uptake A4G13_RS02100 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) A4G13_RS02105 ENOG4105NNH LexA regulated protein A4G13_RS02110 ENOG4105EV9 Alpha Beta Hydrolase A4G13_RS02115 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) A4G13_RS02120 ENOG4105CEY Amp-dependent synthetase and ligase A4G13_RS02125 ENOG4105EGS Mechanosensitive ion channel A4G13_RS02130 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A4G13_RS02135 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) A4G13_RS02140 ENOG4105EJ9 Membrane A4G13_RS02145 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase A4G13_RS02150 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A4G13_RS02155 ENOG4107QMP dna polymerase iii subunits gamma and tau A4G13_RS02165 ENOG4108VTV Inherit from NOG: Membrane A4G13_RS02175 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A4G13_RS02180 ENOG4105CEI nitrite reductase A4G13_RS02185 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A4G13_RS02190 ENOG4105C09 Bile acid A4G13_RS02195 ENOG4105E8V Alpha Beta Hydrolase Fold protein A4G13_RS02200 ENOG4107QW4 alcohol dehydrogenase A4G13_RS02205 ENOG4105EMY transcriptional regulator A4G13_RS02215 ENOG4108Z6Z Transcriptional regulator A4G13_RS02220 ENOG4105C59 p-type ATPase A4G13_RS02225 ENOG4105C59 p-type ATPase A4G13_RS02230 ENOG4108MG3 formate dehydrogenase A4G13_RS02235 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein A4G13_RS02245 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A4G13_RS02250 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) A4G13_RS02255 ENOG4105ETT transcriptional Regulator, LysR family A4G13_RS02260 ENOG4105CM2 brancheD-chain amino acid aminotransferase A4G13_RS02265 ENOG4106J39 exported protein A4G13_RS02270 ENOG4105CFG Acts as a chaperone (By similarity) A4G13_RS02275 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A4G13_RS02280 ENOG4105F87 Dehydratase A4G13_RS02285 ENOG4105CVE Lytic murein transglycosylase A4G13_RS02290 ENOG4108RYC glycosyltransferase A4G13_RS02295 ENOG4108RJ9 Glycosyl transferase, family 2 A4G13_RS02305 ENOG41068D6 Glycosyltransferase A4G13_RS02315 ENOG4108ZPC Polysaccharide pyruvyl transferase A4G13_RS02320 ENOG41080C8 DUF218 domain A4G13_RS02330 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase A4G13_RS02335 ENOG4105ESV Glycosyl transferase, family 4 A4G13_RS02345 ENOG4105C8J )-transporter A4G13_RS02350 ENOG4105CSM endonuclease III A4G13_RS02355 ENOG4105DZB Electron transport complex A4G13_RS02365 ENOG4105D6A Electron transport complex A4G13_RS02370 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) A4G13_RS02375 ENOG4108R3D Electron transport complex A4G13_RS02380 ENOG4105DGN Electron transport complex A4G13_RS02385 ENOG4107GZ4 SanA protein A4G13_RS02390 ENOG4105DWV Homoserine O-trans-acetylase A4G13_RS02395 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase A4G13_RS02400 ENOG4105DJ0 Poly(A) Polymerase A4G13_RS02405 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters A4G13_RS02410 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 A4G13_RS02415 ENOG4105BZ1 (ABC) transporter A4G13_RS02420 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) A4G13_RS02425 ENOG4105W49 UPF0434 protein A4G13_RS02430 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) A4G13_RS02440 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A4G13_RS02455 ENOG4105CKW Inner membrane protein yedI A4G13_RS02460 ENOG4105DDY UPF0142 protein ycaO A4G13_RS02470 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A4G13_RS02475 ENOG4105EZR dyp-type peroxidase family protein A4G13_RS02480 ENOG4105C29 acyl-CoA thioesterase A4G13_RS02490 ENOG4108JJ8 (ABC) transporter A4G13_RS02495 ENOG4108JJ9 ABC, transporter A4G13_RS02500 ENOG4105C3M thioredoxin reductase A4G13_RS02505 ENOG4107QR8 Thioredoxin A4G13_RS02510 ENOG4105C6Z Gluconate A4G13_RS02515 ENOG4105CHR reductase A4G13_RS02520 ENOG4105CPQ Dehydrogenase A4G13_RS02525 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family A4G13_RS02535 ENOG4105CNA YD repeat protein A4G13_RS02550 ENOG4105C2I pirin domain protein A4G13_RS02555 ENOG4105D8V Glucose sorbosone dehydrogenase A4G13_RS02565 ENOG4105CHB tonB-dependent Receptor A4G13_RS02580 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase A4G13_RS02585 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase A4G13_RS02590 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A4G13_RS02595 ENOG4105HBR Rna-binding protein A4G13_RS02600 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) A4G13_RS02605 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A4G13_RS02610 ENOG4105EEI dihydropteroate synthase A4G13_RS02615 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) A4G13_RS02620 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A4G13_RS02625 ENOG4105XPH Ferredoxin A4G13_RS02630 ENOG4107QPK )-transporter A4G13_RS02635 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) A4G13_RS02640 ENOG4105CCF Lysine exporter protein (Lyse ygga) A4G13_RS02645 ENOG4108ZAI phosphatidylglycerophosphatase a A4G13_RS02650 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) A4G13_RS02655 ENOG4107YIM Involved in the transcription termination process (By similarity) A4G13_RS02660 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) A4G13_RS02665 ENOG4105E0U tyrosine-specific transport protein A4G13_RS02675 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) A4G13_RS02700 ENOG4105FB9 CRISPR-associated protein A4G13_RS02715 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A4G13_RS02720 ENOG4105C0H protease A4G13_RS02725 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase A4G13_RS02730 ENOG4105C2X Arabinose 5-phosphate isomerase A4G13_RS02740 ENOG4108DNC Involved in acetate metabolism (By similarity) A4G13_RS02745 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) A4G13_RS02750 ENOG4105PQ6 UPF0208 membrane protein A4G13_RS02755 ENOG4105E96 Colicin v production protein A4G13_RS02760 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase A4G13_RS02765 ENOG4105D06 uba thif-type nad fad binding protein A4G13_RS02770 ENOG4105CVM Molybdenum cofactor synthesis domain protein A4G13_RS02775 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) A4G13_RS02780 ENOG4105C3R Methionine synthase A4G13_RS02785 ENOG4108UK5 Transposase A4G13_RS02800 ENOG4108IHU transport system permease protein A4G13_RS02810 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A4G13_RS02815 ENOG4105XW2 UPF0263 protein A4G13_RS02820 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) A4G13_RS02825 ENOG4105C7N Xanthine uracil vitamin C permease A4G13_RS02830 ENOG41090EX DsrE family A4G13_RS02835 ENOG4105CHW UPF0052 protein A4G13_RS02840 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A4G13_RS02845 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A4G13_RS02850 ENOG4105M00 molybdopterin converting factor, subunit 1 A4G13_RS02855 ENOG4108ZAF Molybdopterin A4G13_RS02870 ENOG4108MG3 formate dehydrogenase A4G13_RS02875 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein A4G13_RS02880 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) A4G13_RS02885 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) A4G13_RS02890 ENOG4105CMT Dihydroxyacetone kinase A4G13_RS02895 ENOG4108UTZ Dihydroxyacetone kinase A4G13_RS02905 ENOG4107RHR regulatoR A4G13_RS02910 ENOG4108YZG isomerase A4G13_RS02915 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A4G13_RS02925 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A4G13_RS02940 ENOG4105CGF Aromatic amino acid aminotransferase A4G13_RS02945 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A4G13_RS02950 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) A4G13_RS02955 ENOG4105CD8 aminopeptidase N A4G13_RS02960 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) A4G13_RS02965 ENOG4105DB7 PHP domain protein A4G13_RS02970 ENOG4107RTD sua5 ycio yrdc ywlc family protein A4G13_RS02975 ENOG4105FE9 pseudouridine synthase A4G13_RS02980 ENOG4107R11 Transcriptional regulator A4G13_RS02995 ENOG4105C5S asparaginyl-tRNA synthetase A4G13_RS03000 ENOG4105EUJ GTP cyclohydrolase i A4G13_RS03005 ENOG4108QD6 A4G13_RS03015 ENOG4105VNG YcgL domain-containing protein A4G13_RS03020 ENOG4105CGK Exodeoxyribonuclease III A4G13_RS03025 ENOG4105GXY Family of unknown function (DUF695) A4G13_RS03030 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 A4G13_RS03040 ENOG4105E9S glutaredoxin 2 A4G13_RS03045 ENOG4105C22 threonyL-tRNA synthetase A4G13_RS03070 ENOG4105DZR Type I site-specific deoxyribonuclease A4G13_RS03080 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) A4G13_RS03085 ENOG41082NX 50s ribosomal protein l35 A4G13_RS03090 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) A4G13_RS03100 ENOG4105DF9 Lipoate-protein, ligase A4G13_RS03105 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A4G13_RS03110 ENOG4105CTB Polyprenyl synthetase A4G13_RS03115 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A4G13_RS03120 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) A4G13_RS03125 ENOG4105ETE Transcriptional regulator (LacI family A4G13_RS03130 ENOG41077A9 carbonic anhydrase A4G13_RS03135 ENOG4105DA5 (ABC) transporter A4G13_RS03140 ENOG4105E3A (ABC) transporter A4G13_RS03145 ENOG4105EWT decarboxylase family A4G13_RS03150 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) A4G13_RS03155 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein A4G13_RS03160 ENOG4105WP7 tRNA pseudouridine synthase C A4G13_RS03165 ENOG4105DR9 pseudouridine synthase A4G13_RS03170 ENOG4105DBV ornithine carbamoyltransferase A4G13_RS03175 ENOG4105X5C UPF0181 protein A4G13_RS03180 ENOG4105Q9Y Universal stress protein A4G13_RS03185 ENOG4105DS0 Transcriptional regulator, Crp Fnr family A4G13_RS03190 ENOG41090A1 ferritin A4G13_RS03195 ENOG41090A1 ferritin A4G13_RS03200 ENOG4105CJB Exodeoxyribonuclease I A4G13_RS03205 ENOG4108TZV Membrane A4G13_RS03215 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) A4G13_RS03220 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) A4G13_RS03225 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) A4G13_RS03230 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) A4G13_RS03235 ENOG4108QBX (LipO)protein A4G13_RS03240 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) A4G13_RS03245 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A4G13_RS03250 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) A4G13_RS03255 ENOG4105KWI UPF0339 protein A4G13_RS03265 ENOG4105VDM plasmid maintenance system antidote protein, xre family A4G13_RS03270 ENOG4105VEQ Cold shock protein A4G13_RS03275 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A4G13_RS03280 ENOG4105CC0 LysR family Transcriptional regulator A4G13_RS03285 ENOG4107QYX exodeoxyribonuclease v alpha A4G13_RS03290 ENOG4107QKA exodeoxyribonuclease V beta A4G13_RS03295 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A4G13_RS03300 ENOG4105EHE chorismate mutase- prephenate dehydrogenase A4G13_RS03305 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) A4G13_RS03310 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A4G13_RS03315 ENOG4105D07 Signal peptide peptidase, SppA A4G13_RS03320 ENOG41069NU Nitroreductase A4G13_RS03325 ENOG41069UX Beta-N-acetyl-hexosaminidase A4G13_RS03335 ENOG4105CND Glycosyl transferase, family 2 A4G13_RS03340 ENOG4107BJW polysaccharide deacetylase A4G13_RS03350 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) A4G13_RS03355 ENOG4108VD1 dedA family A4G13_RS03360 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) A4G13_RS03365 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) A4G13_RS03370 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) A4G13_RS03375 ENOG4108ESZ Glycogen debranching enzyme A4G13_RS03380 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) A4G13_RS03385 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) A4G13_RS03390 ENOG4108ZZ3 UPF0260 protein A4G13_RS03400 ENOG4105CX6 glutaminyL-tRNA synthetase A4G13_RS03405 ENOG4105DJY efflux transporter, rnd family, mfp subunit A4G13_RS03410 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) A4G13_RS03415 ENOG4105ENJ RND efflux system, outer membrane lipoprotein A4G13_RS03420 ENOG4108BPE -transporting atpase A4G13_RS03425 ENOG4105D0M Protease HtpX homolog A4G13_RS03430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A4G13_RS03435 ENOG4105CPB ATP-dependent endonuclease of the OLD family A4G13_RS03440 ENOG4105DWU Membrane A4G13_RS03450 ENOG4107RM6 sulfurtransferase A4G13_RS03455 ENOG4107RM6 sulfurtransferase A4G13_RS03460 ENOG4105CUC YeeE YedE family protein A4G13_RS03475 ENOG4105ERU peptidase A4G13_RS03480 ENOG4105CRQ synthase (Component I) A4G13_RS03485 ENOG4105DDQ anthranilate synthase A4G13_RS03490 ENOG4107QYG anthranilate phosphoribosyltransferase A4G13_RS03495 ENOG4105DK0 Indole-3-glycerol phosphate synthase A4G13_RS03500 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) A4G13_RS03505 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) A4G13_RS03515 ENOG4105CE1 Ferrous iron transport protein b A4G13_RS03555 ENOG4105CKT filamentous hemagglutinin A4G13_RS03565 ENOG4105D5K Hemolysin activator protein A4G13_RS03570 ENOG4108W1A pseudouridine synthase A4G13_RS03580 ENOG4108TGR phosphatase A4G13_RS03585 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A4G13_RS03590 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) A4G13_RS03595 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A4G13_RS03600 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) A4G13_RS03610 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein A4G13_RS03615 ENOG4107QP8 phosphohexose isomerase A4G13_RS03620 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A4G13_RS03625 ENOG4105CDU Replicative dna helicase A4G13_RS03630 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) A4G13_RS03635 ENOG4105D60 lipoprotein releasing system transmembrane protein A4G13_RS03640 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A4G13_RS03645 ENOG4105D60 lipoprotein releasing system transmembrane protein A4G13_RS03650 ENOG4105C5I Dehydrogenase A4G13_RS03655 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A4G13_RS03660 ENOG41063JG Transcriptional regulator A4G13_RS03665 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A4G13_RS03670 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A4G13_RS03680 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) A4G13_RS03685 ENOG4105DAN ATP-dependent protease A4G13_RS03695 ENOG4105CA9 Pyruvate kinase A4G13_RS03700 ENOG4108BY2 phosphohistidine phosphatase A4G13_RS03710 ENOG4105DGW oligopeptidase A A4G13_RS03715 ENOG4105E0A ABC, transporter A4G13_RS03725 ENOG4105S6R Iron-hydroxamate transporter permease subunit A4G13_RS03730 ENOG4105IBP Cyclic peptide transporter A4G13_RS03750 ENOG4105CV8 reductase A4G13_RS03755 ENOG4105EQ2 LysR family Transcriptional regulator A4G13_RS03760 ENOG4108ENG carbohydrate kinase, YjeF related protein A4G13_RS03770 ENOG4105HA9 of methanol dehydrogenase type A4G13_RS03780 ENOG4108V0P LemA family A4G13_RS03795 ENOG4105CQB FAD linked oxidase domain protein A4G13_RS03805 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A4G13_RS03810 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A4G13_RS03820 ENOG4105CT4 transporter A4G13_RS03825 ENOG4108K2B transcriptional regulator A4G13_RS03830 ENOG4105PW4 Sugar fermentation stimulation protein homolog A4G13_RS03835 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A4G13_RS03840 ENOG4105D7K pfkb domain protein A4G13_RS03845 ENOG4105CG3 alpha amylase, catalytic region A4G13_RS03850 ENOG4105C5Y PTS System A4G13_RS03860 ENOG4105C5H ABC transporter A4G13_RS03870 ENOG4105DIQ Transcriptional regulator A4G13_RS03875 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) A4G13_RS03880 ENOG4105DHQ Histidine kinase A4G13_RS03885 ENOG4105XJC Two component transcriptional regulator (Winged helix family A4G13_RS03895 ENOG4107QZB decarboxylase A4G13_RS03900 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) A4G13_RS03905 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A4G13_RS03925 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A4G13_RS03930 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein A4G13_RS03935 ENOG4108I5D sulfate abc transporter A4G13_RS03940 ENOG4105ECW sulfate abc transporter A4G13_RS03945 ENOG4108IJ6 ABC transporter A4G13_RS03950 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) A4G13_RS03955 ENOG4105D1S lipid A biosynthesis A4G13_RS03960 ENOG4108DG9 Smr protein MutS2 A4G13_RS03965 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) A4G13_RS03970 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A4G13_RS03975 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) A4G13_RS03980 ENOG4105ECP epimerase A4G13_RS03985 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein A4G13_RS03990 ENOG41067MG lrgb family A4G13_RS03995 ENOG4105VAW lrga family A4G13_RS04000 ENOG4105KK6 nuclease A4G13_RS04005 ENOG4105C9B Cysteine desulfurase A4G13_RS04010 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) A4G13_RS04015 ENOG4105CDA abc transporter atp-binding protein A4G13_RS04020 ENOG4105E5Q amino acid AbC transporter A4G13_RS04025 ENOG4105EAB amino acid AbC transporter A4G13_RS04030 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) A4G13_RS04035 ENOG4105KB2 stringent starvation protein b A4G13_RS04040 ENOG4107MKT Stringent starvation protein a A4G13_RS04045 ENOG4108UJD 30S ribosomal protein S9 A4G13_RS04050 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) A4G13_RS04060 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III A4G13_RS04065 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A4G13_RS04070 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) A4G13_RS04075 ENOG41082RQ UPF0102 protein A4G13_RS04080 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) A4G13_RS04085 ENOG4105W4M Transport-associated protein A4G13_RS04090 ENOG4105K3M )-transporter A4G13_RS04125 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) A4G13_RS04130 ENOG4105C12 Phosphoribosylglycinamide synthetase A4G13_RS04135 ENOG4105DC1 bifunctional purine biosynthesis protein purh A4G13_RS04140 ENOG4108KXH Ybak prolyl-tRNA synthetase associated A4G13_RS04155 ENOG4105D0S secretion protein (HlyD A4G13_RS04160 ENOG4105CJ1 ABC, transporter A4G13_RS04165 ENOG4105CMI transporter A4G13_RS04175 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) A4G13_RS04180 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A4G13_RS04185 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A4G13_RS04190 ENOG4108ZIG UPF0231 protein A4G13_RS04195 ENOG4105EJQ L-serine dehydratase A4G13_RS04200 ENOG4105BZ4 penicillin-binding protein A4G13_RS04205 ENOG4108R6K riboflavin synthase, subunit alpha A4G13_RS04210 ENOG4107QI1 Mate efflux family protein A4G13_RS04220 ENOG4105CQ0 ABC transporter A4G13_RS04225 ENOG4107B7Y DNA-binding transcriptional regulator FruR A4G13_RS04230 ENOG4108ZP8 Acetolactate synthase small subunit A4G13_RS04235 ENOG4105C7K acetolactate synthase A4G13_RS04240 ENOG4107S6Z Na H antiporter A4G13_RS04245 ENOG4108SAU DNA-binding protein H-ns A4G13_RS04250 ENOG4105CIY formyltetrahydrofolate deformylase A4G13_RS04255 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) A4G13_RS04260 ENOG4107TSG Extracellular solute-binding protein, family 5 A4G13_RS04265 ENOG4108XTF Outer Membrane Lipoprotein A4G13_RS04275 ENOG4105NBI YecM protein A4G13_RS04280 ENOG4105C75 arginyL-tRNA synthetase A4G13_RS04295 ENOG4107TT5 NLP P60 protein A4G13_RS04300 ENOG4107QN2 dihydrolipoyl dehydrogenase A4G13_RS04305 ENOG4107QSN dihydrolipoamide acetyltransferase A4G13_RS04310 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) A4G13_RS04325 ENOG4105WDY DNA (cytosine-5-)-methyltransferase A4G13_RS04330 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) A4G13_RS04335 ENOG4105E0C molybdate abc transporter A4G13_RS04340 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A4G13_RS04345 ENOG4105F4R Transcriptional regulator mode A4G13_RS04350 ENOG4105KA0 thioesterase Superfamily protein A4G13_RS04355 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A4G13_RS04385 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha A4G13_RS04390 ENOG4105CMV Succinyl-CoA synthetase subunit beta A4G13_RS04395 ENOG4105C7S Dehydrogenase A4G13_RS04400 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 A4G13_RS04405 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) A4G13_RS04410 ENOG4105CEY Amp-dependent synthetase and ligase A4G13_RS04415 ENOG4105R8X Outer membrane lipoprotein Slp A4G13_RS04420 ENOG41072GX Peptidase M22 Glycoprotease A4G13_RS04425 ENOG4105DVT helicase A4G13_RS04430 ENOG4105DSB aldose 1-epimerase A4G13_RS04440 ENOG4108JQ7 (ABC) transporter A4G13_RS04445 ENOG4105C3U ABC transporter A4G13_RS04450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A4G13_RS04455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A4G13_RS04460 ENOG4105C4R Atp-dependent dna helicase A4G13_RS04465 ENOG4105C4Y ABC transporter A4G13_RS04470 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A4G13_RS04485 ENOG4105C0H protease A4G13_RS04490 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) A4G13_RS04495 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) A4G13_RS04500 ENOG4108V1U phospholipid-binding protein A4G13_RS04505 ENOG4105C8P )-transporter A4G13_RS04510 ENOG4105VUC UPF0237 protein A4G13_RS04525 ENOG4105VUF Transcriptional regulator A4G13_RS04535 ENOG4105C4W S-formylglutathione hydrolase A4G13_RS04540 ENOG4105D9R oxidoreductase A4G13_RS04560 ENOG4105DEN Luciferase family A4G13_RS04565 ENOG4105EQ2 LysR family Transcriptional regulator A4G13_RS04575 ENOG41090HT Inherit from COG: transposase A4G13_RS04595 ENOG4105E4P ATPase (AAA A4G13_RS04600 ENOG4105EQ2 LysR family Transcriptional regulator A4G13_RS04640 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase A4G13_RS04645 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr A4G13_RS04650 ENOG4105C2C drug resistance transporter, Bcr CflA A4G13_RS04655 ENOG4105EE0 oxidoreductase A4G13_RS04670 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF A4G13_RS04675 ENOG4105CPC Aldo Keto reductase A4G13_RS04685 ENOG4105PGM cation diffusion facilitator family transporter A4G13_RS04690 ENOG4107PN8 YfeABCD locus regulator A4G13_RS04695 ENOG4105CQ7 ATP-dependent helicase A4G13_RS04700 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family A4G13_RS04705 ENOG4108VMM UPF0756 membrane protein A4G13_RS04715 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A4G13_RS04720 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) A4G13_RS04725 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) A4G13_RS04730 ENOG4105CHV Transcription elongation factor NusA A4G13_RS04735 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) A4G13_RS04745 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase A4G13_RS04755 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) A4G13_RS04760 ENOG4105D1H recombination factor protein RarA A4G13_RS04765 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) A4G13_RS04770 ENOG4105CNU cell division protein FtsK A4G13_RS04775 ENOG4105EW9 transcriptional regulator AsnC family A4G13_RS04785 ENOG4105NXV High-affinity zinc uptake system protein A4G13_RS04790 ENOG4105CUZ uba thif-type nad fad binding protein A4G13_RS04795 ENOG4105CA3 membrane-bound lytic murein transglycosylase A4G13_RS04805 ENOG4105C45 hydrogenase expression formation protein (HypE) A4G13_RS04810 ENOG4105CQS hydrogenase expression formation protein HypD A4G13_RS04815 ENOG4107RSS Hydrogenase accessory protein HypB A4G13_RS04820 ENOG4107QNR UPF0135 protein A4G13_RS04825 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A4G13_RS04830 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) A4G13_RS04840 ENOG4108ZJT translation initiation factor, Sui1 A4G13_RS04845 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) A4G13_RS04850 ENOG4105CFV Tetratricopeptide repeat protein A4G13_RS04855 ENOG4105Q4A inner membrane protein yciS A4G13_RS04860 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) A4G13_RS04865 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) A4G13_RS04870 ENOG4105CAT Cytidine monophosphate kinase A4G13_RS04880 ENOG4105CDH Citrulline--aspartate ligase A4G13_RS04885 ENOG4107SRH Nad-dependent epimerase dehydratase A4G13_RS04890 ENOG4105C8V SAICAR synthetase A4G13_RS04900 ENOG4108F2G Chain length determinant protein A4G13_RS04905 ENOG4105DAY polysaccharide export protein A4G13_RS04915 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A4G13_RS04930 ENOG4105D3Q Sugar transferase A4G13_RS04950 ENOG4105E2K Glycosyl transferase (Group 1 A4G13_RS04960 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A4G13_RS04965 ENOG4105J5G Transferase hexapeptide repeat containing protein A4G13_RS04970 ENOG4107R5Z Oxidoreductase domain protein A4G13_RS04975 ENOG4107QQG Dehydrogenase A4G13_RS04980 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) A4G13_RS04985 ENOG41065U4 response regulator A4G13_RS04990 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) A4G13_RS04995 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) A4G13_RS05000 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) A4G13_RS05005 ENOG4105C5Y PTS System A4G13_RS05010 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A4G13_RS05015 ENOG4105KZ7 phosphocarrier protein hpr A4G13_RS05020 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A4G13_RS05025 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) A4G13_RS05040 ENOG4105K8N protein family UPF0079, ATPase A4G13_RS05045 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A4G13_RS05050 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) A4G13_RS05060 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) A4G13_RS05065 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A4G13_RS05070 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A4G13_RS05075 ENOG4105C28 cystathionine A4G13_RS05080 ENOG4105D3R alkyl hydroperoxide reductase A4G13_RS05090 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) A4G13_RS05095 ENOG4107T0D ABC, transporter A4G13_RS05100 ENOG4106SMU thiamine transporter membrane protein A4G13_RS05105 ENOG4105DP9 ABC transporter A4G13_RS05110 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) A4G13_RS05125 ENOG4105EAA nucleoside A4G13_RS05135 ENOG4105EYK Phosphatidylglycerophosphatase B A4G13_RS05140 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) A4G13_RS05145 ENOG410867C Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) A4G13_RS05150 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) A4G13_RS05155 ENOG4105C5T Phosphoribosyl pyrophosphate synthase A4G13_RS05160 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) A4G13_RS05170 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A4G13_RS05175 ENOG4105T95 Thiol disulfide interChange protein A4G13_RS05185 ENOG4105CRK lysyL-tRNA synthetase A4G13_RS05190 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) A4G13_RS05195 ENOG4105C8H hydrogenase maturation protein Hypf A4G13_RS05205 ENOG4108K5H permease YjgP YjgQ family protein A4G13_RS05210 ENOG4108M8S permease YjgP YjgQ family protein A4G13_RS05215 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A4G13_RS05225 ENOG4105CH2 amidohydrolase A4G13_RS05240 ENOG4105CE7 Amidase, hydantoinase carbamoylase family A4G13_RS05245 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A4G13_RS05250 ENOG4105MYG DNA polymerase iii, chi subunit A4G13_RS05255 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) A4G13_RS05260 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A4G13_RS05265 ENOG4105NSG hemerythrin hhe cation binding domain protein A4G13_RS05275 ENOG4105VIE preprotein translocase, subunit YajC A4G13_RS05280 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A4G13_RS05285 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A4G13_RS05290 ENOG4107SC1 transglycosylase A4G13_RS05300 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase A4G13_RS05305 ENOG4105EMU Dehydrogenase A4G13_RS05310 ENOG4105E0M Sulfatase A4G13_RS05325 ENOG4107RZZ dna polymerase iii epsilon subunit A4G13_RS05330 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A4G13_RS05335 ENOG41090HJ UPF0265 protein A4G13_RS05340 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A4G13_RS05345 ENOG4105CIH Imidazole acetol-phosphate transaminase A4G13_RS05350 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase A4G13_RS05355 ENOG41079J1 A4G13_RS05370 ENOG4105F27 Major Facilitator A4G13_RS05380 ENOG4105DHP deoxycytidine triphosphate deaminase A4G13_RS05385 ENOG4105DBI uridine monophosphokinase A4G13_RS05390 ENOG4105C4Y ABC transporter A4G13_RS05395 ENOG4105C4Y ABC transporter A4G13_RS05400 ENOG4107RCV ABC transporter, permease A4G13_RS05405 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A4G13_RS05410 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) A4G13_RS05415 ENOG4108WPU DNA polymerase III subunit psi A4G13_RS05420 ENOG4105KEG ribosomal-protein-alanine acetyltransferase A4G13_RS05425 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A4G13_RS05430 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) A4G13_RS05435 ENOG4105C1B dTDP-glucose 4-6-dehydratase A4G13_RS05440 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control A4G13_RS05445 ENOG4105QYV Membrane A4G13_RS05450 ENOG4105QYV Membrane A4G13_RS05455 ENOG4105K46 50S ribosomal protein l27 A4G13_RS05460 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A4G13_RS05465 ENOG4105EAH synthase A4G13_RS05470 ENOG4105WPN DNA integration recombination invertion protein A4G13_RS05475 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) A4G13_RS05480 ENOG4105EN6 Membrane A4G13_RS05485 ENOG4105CMT Dihydroxyacetone kinase A4G13_RS05490 ENOG4108UTZ Dihydroxyacetone kinase A4G13_RS05495 ENOG4105VDH Dihydroxyacetone kinase A4G13_RS05500 ENOG4105CMG Carbohydrate kinase A4G13_RS05505 ENOG4105CNN ABC, transporter A4G13_RS05515 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A4G13_RS05520 ENOG4105CFH Aspartokinase A4G13_RS05525 ENOG4105DFU Cell wall formation (By similarity) A4G13_RS05530 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 A4G13_RS05545 ENOG4107QJR hflk protein A4G13_RS05550 ENOG4105EPW hflc protein A4G13_RS05555 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A4G13_RS05560 ENOG4105C03 ribonuclease A4G13_RS05565 ENOG4105EI2 Pseudouridine synthase A4G13_RS05575 ENOG4105K63 Thioredoxin A4G13_RS05580 ENOG4105C28 cystathionine A4G13_RS05605 ENOG4107RN3 metallophosphoesterase A4G13_RS05610 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A4G13_RS05615 ENOG4105D1F ATP-binding protein A4G13_RS05620 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) A4G13_RS05625 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) A4G13_RS05630 ENOG4105E33 succinate dehydrogenase A4G13_RS05635 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) A4G13_RS05640 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) A4G13_RS05645 ENOG4105CQC Prephenate dehydratase A4G13_RS05655 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A4G13_RS05660 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A4G13_RS05665 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A4G13_RS05670 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) A4G13_RS05675 ENOG4105CPF Cell wall formation (By similarity) A4G13_RS05680 ENOG4105DFU Cell wall formation (By similarity) A4G13_RS05685 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A4G13_RS05690 ENOG4105CNI cell division protein FtsW A4G13_RS05695 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) A4G13_RS05700 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) A4G13_RS05705 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) A4G13_RS05710 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A4G13_RS05715 ENOG4105CJN penicillin-binding protein A4G13_RS05725 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A4G13_RS05730 ENOG4108V6E Cell division protein mraZ A4G13_RS05750 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) A4G13_RS05755 ENOG4105C9A Phoh family A4G13_RS05760 ENOG4105D9M gamma-glutamylcysteine synthetase A4G13_RS05765 ENOG4105CT1 (ABC) transporter A4G13_RS05775 ENOG4105E5Q amino acid AbC transporter A4G13_RS05780 ENOG4105EAD ABC transporter A4G13_RS05790 ENOG410642W LysR family Transcriptional regulator A4G13_RS05795 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A4G13_RS05810 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) A4G13_RS05815 ENOG41087AY ADP-Ribose pyrophosphatase A4G13_RS05820 ENOG4105W8Z 4'-phosphopantetheinyl transferase A4G13_RS05825 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) A4G13_RS05835 ENOG4105GPY SprT protein A4G13_RS05840 ENOG4105D98 threonine synthase A4G13_RS05845 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) A4G13_RS05850 ENOG4105CFH Aspartokinase A4G13_RS05855 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A4G13_RS05860 ENOG4105DFA alanine racemase domain protein A4G13_RS05865 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A4G13_RS05870 ENOG4105VFK BolA family A4G13_RS05880 ENOG4105E3I toluene tolerance A4G13_RS05885 ENOG4107PE3 Mammalian cell entry related domain protein A4G13_RS05890 ENOG4105CY3 ABC transporter, permease A4G13_RS05895 ENOG4105DHJ ABC, transporter A4G13_RS05900 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) A4G13_RS05905 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA A4G13_RS05910 ENOG4108IUZ ABC transporter A4G13_RS05915 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN A4G13_RS05920 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A4G13_RS05925 ENOG4105WVQ Fe-S assembly protein IscX A4G13_RS05930 ENOG4108ZIT Ferredoxin, 2FE-2S A4G13_RS05935 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB A4G13_RS05940 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) A4G13_RS05945 ENOG4108Z4V iron-sulfur cluster assembly A4G13_RS05950 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins A4G13_RS05960 ENOG4105C3J Cysteine desulfurase A4G13_RS05965 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family A4G13_RS05970 ENOG4105CVS RNA methyltransferase TrmH family, group 1 A4G13_RS05975 ENOG4105ECY inositol monophosphatase A4G13_RS05980 ENOG4105BZU Histidine kinase A4G13_RS06010 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A4G13_RS06015 ENOG4105CB5 ATP-dependent DNA helicase recG A4G13_RS06020 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A4G13_RS06025 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) A4G13_RS06030 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) A4G13_RS06035 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A4G13_RS06040 ENOG4105CAZ oligogalacturonide lyase A4G13_RS06055 ENOG4108JQ1 Dehydrogenase A4G13_RS06060 ENOG4105E66 phosphoriboisomerase A A4G13_RS06065 ENOG4105CSA Coproporphyrinogen iii oxidase A4G13_RS06070 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A4G13_RS06075 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein A4G13_RS06080 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) A4G13_RS06085 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) A4G13_RS06090 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A4G13_RS06095 ENOG4105DTN riboflavin biosynthesis protein ribF A4G13_RS06110 ENOG4105CJR Integral membrane protein (MviN A4G13_RS06115 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) A4G13_RS06120 ENOG41062Z9 Membrane A4G13_RS06125 ENOG4105EAC phosphoserine phosphatase A4G13_RS06130 ENOG4108VPT UPF0234 protein A4G13_RS06140 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A4G13_RS06145 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A4G13_RS06155 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A4G13_RS06160 ENOG4107104 thymidine kinase A4G13_RS06170 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) A4G13_RS06175 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) A4G13_RS06185 ENOG4105C6T cysteine synthase A4G13_RS06260 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A4G13_RS06265 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) A4G13_RS06275 ENOG4108IA2 Sodium pantothenate symporter A4G13_RS06280 ENOG4105RG0 Membrane A4G13_RS06285 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A4G13_RS06290 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein A4G13_RS06295 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) A4G13_RS06300 ENOG4105DNI Converts SHCHC to OSB (By similarity) A4G13_RS06315 ENOG4105DJ4 phosphatidylserine decarboxylase A4G13_RS06320 ENOG4108V1T peptidylprolyl cis-trans isomerase A4G13_RS06325 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A4G13_RS06330 ENOG4105DWK Membrane A4G13_RS06335 ENOG4107XM3 UPF0442 protein A4G13_RS06340 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) A4G13_RS06345 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) A4G13_RS06350 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase A4G13_RS06355 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) A4G13_RS06360 ENOG4105CGZ zinc metallopeptidase A4G13_RS06380 ENOG4108WZM domain protein A4G13_RS06385 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A4G13_RS06390 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A4G13_RS06395 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) A4G13_RS06400 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A4G13_RS06405 ENOG4105EIN peptidylprolyl cis-trans isomerase A4G13_RS06410 ENOG4108R96 Methyltransferase, YaeB family A4G13_RS06415 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A4G13_RS06420 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) A4G13_RS06425 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) A4G13_RS06430 ENOG4105C1J atp-dependent rna helicase A4G13_RS06435 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) A4G13_RS06440 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) A4G13_RS06445 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) A4G13_RS06450 ENOG4105CJN penicillin-binding protein A4G13_RS06455 ENOG4105CNI cell division protein FtsW A4G13_RS06460 ENOG4105K6T rare lipoprotein A A4G13_RS06465 ENOG4105DZ1 carboxypeptidase A4G13_RS06475 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) A4G13_RS06480 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) A4G13_RS06490 ENOG4107ZVW dihydroneopterin aldolase A4G13_RS06495 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A4G13_RS06500 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A4G13_RS06505 ENOG4105C34 Pseudouridine synthase A4G13_RS06510 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane A4G13_RS06515 ENOG4105EAU Plays a role in nitrite reduction (By similarity) A4G13_RS06520 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit A4G13_RS06525 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein A4G13_RS06530 ENOG4105DVI reductase, NrfD A4G13_RS06535 ENOG4105DA4 cytochrome c-type biogenesis protein A4G13_RS06540 ENOG4107QX9 Thiol disulfide interChange protein A4G13_RS06545 ENOG4108DMF Cytochrome C biogenesis protein A4G13_RS06550 ENOG4108DMF Cytochrome C biogenesis protein A4G13_RS06555 ENOG4105CBX hi0933 family A4G13_RS06565 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) A4G13_RS06570 ENOG4107QIK phosphoribosylformylglycinamidine synthase A4G13_RS06590 ENOG4105DUM transcriptional regulator, lysR family A4G13_RS06595 ENOG4105HMI Membrane A4G13_RS06615 ENOG4105C0A alcohol dehydrogenase A4G13_RS06620 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) A4G13_RS06625 ENOG4105DH7 May be involved in recombination (By similarity) A4G13_RS06630 ENOG4105II7 pyrroline-5-carboxylate reductase A4G13_RS06635 ENOG4105D8G Major Facilitator superfamily A4G13_RS06640 ENOG4105CHM Aminotransferase A4G13_RS06645 ENOG4105E4F Isochorismate synthase A4G13_RS06650 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) A4G13_RS06655 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) A4G13_RS06660 ENOG4108IPT Naphthoate synthase A4G13_RS06675 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein A4G13_RS06685 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) A4G13_RS06690 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A4G13_RS06695 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A4G13_RS06700 ENOG4105CHR reductase A4G13_RS06705 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A4G13_RS06710 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter A4G13_RS06715 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) A4G13_RS06720 ENOG4105C2W permease A4G13_RS06725 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) A4G13_RS06730 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase A4G13_RS06735 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) A4G13_RS06740 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase A4G13_RS06750 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) A4G13_RS06775 ENOG4105C4K Nad synthetase A4G13_RS06780 ENOG4105DAP Nicotinate phosphoribosyltransferase A4G13_RS06785 ENOG4105ECC imidazole-glycerol-phosphate dehydratase A4G13_RS06790 ENOG4105CIH Imidazole acetol-phosphate transaminase A4G13_RS06795 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) A4G13_RS06800 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) A4G13_RS06805 ENOG4105DMQ Methyltransferase A4G13_RS06810 ENOG4105CIC tryptophan-specific transport protein A4G13_RS06815 ENOG4108VW9 Membrane A4G13_RS06820 ENOG4105D9N nucleoside A4G13_RS06825 ENOG4105D3A purine nucleoside phosphorylase DeoD-type A4G13_RS06830 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) A4G13_RS06840 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) A4G13_RS06845 ENOG4105PAD Hydrolase A4G13_RS06860 ENOG4105E68 Sulfatase A4G13_RS06865 ENOG4105YDX UPF0352 protein A4G13_RS06870 ENOG4106V8H Nucleoid-associated protein A4G13_RS06875 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) A4G13_RS06880 ENOG4105E3W Two component transcriptional regulator (Winged helix family A4G13_RS06885 ENOG4105E0F Histidine kinase A4G13_RS06890 ENOG4105C8P )-transporter A4G13_RS06895 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A4G13_RS06900 ENOG41090FY type IV pilus biogenesis stability protein PilW A4G13_RS06905 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) A4G13_RS06910 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) A4G13_RS06915 ENOG4105CUT histidyl-tRNA synthetase A4G13_RS06920 ENOG4105N21 Membrane A4G13_RS06925 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A4G13_RS06935 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane A4G13_RS06940 ENOG4105DZP Membrane-associated zinc metalloprotease A4G13_RS06945 ENOG4105KNE Phosphatidate cytidylyltransferase A4G13_RS06950 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A4G13_RS06955 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) A4G13_RS06960 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) A4G13_RS06965 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A4G13_RS06970 ENOG4108I6E Sulfatase A4G13_RS06975 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) A4G13_RS06980 ENOG4105CE9 30S ribosomal protein S2 A4G13_RS06985 ENOG4107RYR Transcriptional regulator, Crp Fnr family A4G13_RS06995 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) A4G13_RS07000 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) A4G13_RS07005 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A4G13_RS07015 ENOG4105KDC 50s ribosomal protein l28 A4G13_RS07020 ENOG4105W0E 50S ribosomal protein L33 A4G13_RS07025 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A4G13_RS07030 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) A4G13_RS07040 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) A4G13_RS07045 ENOG4105C1J atp-dependent rna helicase A4G13_RS07050 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) A4G13_RS07055 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase A4G13_RS07060 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit A4G13_RS07075 ENOG4105WDY DNA (cytosine-5-)-methyltransferase A4G13_RS07080 ENOG4105C38 Glycyl-tRNA synthetase beta subunit A4G13_RS07095 ENOG4105K89 arsenate reductase A4G13_RS07110 ENOG4105DKP glycosyl transferase, family 9 A4G13_RS07115 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) A4G13_RS07120 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A4G13_RS07130 ENOG4105DFE Dna adenine methylase A4G13_RS07135 ENOG4105D49 3-dehydroquinate synthase A4G13_RS07140 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A4G13_RS07145 ENOG4105E4G Type IV pilus A4G13_RS07170 ENOG4108JQC penicillin-binding protein 1A A4G13_RS07175 ENOG4105D6S protein involved in catabolism of external DNA A4G13_RS07180 ENOG4105C6Z Gluconate A4G13_RS07185 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) A4G13_RS07190 ENOG4105FB2 class II Aldolase A4G13_RS07195 ENOG4105G63 Type III effector Hrp-dependent A4G13_RS07200 ENOG4105ZXK Dehydrogenase A4G13_RS07205 ENOG4105MVE transcriptional regulator A4G13_RS07210 ENOG4108IJ0 Aspartate ammonia-lyase A4G13_RS07215 ENOG4105DC8 reductase A4G13_RS07220 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate A4G13_RS07225 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) A4G13_RS07230 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A4G13_RS07235 ENOG4105CXY transporter A4G13_RS07240 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase A4G13_RS07245 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A A4G13_RS07250 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B A4G13_RS07255 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A4G13_RS07260 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) A4G13_RS07265 ENOG4105C0P Mg chelatase subunit ChlI A4G13_RS07275 ENOG4105EM2 membrane A4G13_RS07280 ENOG4108ZT0 50S ribosomal protein l17 A4G13_RS07285 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A4G13_RS07290 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) A4G13_RS07295 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) A4G13_RS07300 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits A4G13_RS07305 ENOG41067V7 50S ribosomal protein L36 A4G13_RS07310 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A4G13_RS07315 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) A4G13_RS07325 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) A4G13_RS07330 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) A4G13_RS07335 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A4G13_RS07340 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) A4G13_RS07345 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) A4G13_RS07350 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits A4G13_RS07355 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) A4G13_RS07365 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal A4G13_RS07370 ENOG41083MP 50s ribosomal protein l29 A4G13_RS07375 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) A4G13_RS07380 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) A4G13_RS07385 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) A4G13_RS07390 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) A4G13_RS07395 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity A4G13_RS07400 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) A4G13_RS07405 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) A4G13_RS07410 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) A4G13_RS07420 ENOG4105HDK L-asparaginase A4G13_RS07430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A4G13_RS07435 ENOG4105DEF Extracellular solute-binding protein, family 5 A4G13_RS07440 ENOG4105C0R drug resistance transporter emrb qaca subfamily A4G13_RS07445 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b A4G13_RS07450 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) A4G13_RS07460 ENOG4108Z33 Thiol disulfide Interchange Protein A4G13_RS07465 ENOG4108WFC UPF0438 protein yifE A4G13_RS07475 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) A4G13_RS07480 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) A4G13_RS07485 ENOG4107W52 maltose operon periplasmic protein A4G13_RS07490 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) A4G13_RS07495 ENOG4108IJ9 (ABC) transporter A4G13_RS07500 ENOG4107FKK extracellular solute-binding protein family 1 A4G13_RS07505 ENOG4105D56 permease protein A4G13_RS07510 ENOG4105EG2 ABC transporter, permease A4G13_RS07515 ENOG4107T9C Alpha amylase catalytic region A4G13_RS07520 ENOG41061ZR Transcriptional regulator A4G13_RS07525 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) A4G13_RS07530 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) A4G13_RS07535 ENOG4107QM2 Aldo Keto reductase A4G13_RS07540 ENOG4105C5I Dehydrogenase A4G13_RS07545 ENOG4105C9U ATP-dependent DNA helicase RecQ A4G13_RS07550 ENOG4105XQ6 frataxin-like protein A4G13_RS07560 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A4G13_RS07565 ENOG4108K3A Glutathione S-transferase A4G13_RS07580 ENOG4105DJY efflux transporter, rnd family, mfp subunit A4G13_RS07600 ENOG4105MGM doxx family A4G13_RS07605 ENOG4105CKD glutathione-regulated potassium-efflux system protein A4G13_RS07610 ENOG4105C2I pirin domain protein A4G13_RS07615 ENOG4105EXG Transcriptional regulator A4G13_RS07620 ENOG4105C26 Dehydrogenase A4G13_RS07625 ENOG4108MCI Transcriptional regulator, ARAC family A4G13_RS07630 ENOG4105EJC lysr family transcriptional regulator A4G13_RS07635 ENOG4105ENX hydrolase A4G13_RS07640 ENOG4108UW5 maltose o-acetyltransferase A4G13_RS07675 ENOG4105CIN aminoacyl-histidine dipeptidase A4G13_RS07680 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) A4G13_RS07690 ENOG4105EXG Transcriptional regulator A4G13_RS07695 ENOG4108RCM Nitroreductase A4G13_RS07715 ENOG4105E4P ATPase (AAA A4G13_RS07730 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A4G13_RS07745 ENOG4105CF7 AraC family transcriptional regulator A4G13_RS07755 ENOG4105CNV Aldolase A4G13_RS07765 ENOG4108ZHJ Organic hydroperoxide resistance protein A4G13_RS07775 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A4G13_RS07790 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A4G13_RS07795 ENOG4107SET aldo keto reductase A4G13_RS07800 ENOG4105EMY transcriptional regulator A4G13_RS07820 ENOG4105EJC lysr family transcriptional regulator A4G13_RS07830 ENOG4108RCM Nitroreductase A4G13_RS07835 ENOG4105DND Transcriptional regulator A4G13_RS07840 ENOG4105CC0 LysR family Transcriptional regulator A4G13_RS07845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A4G13_RS07895 ENOG4105EMU Dehydrogenase A4G13_RS07915 ENOG4105DM4 PTS System A4G13_RS07920 ENOG4105DE4 1-phosphofructokinase A4G13_RS07925 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein A4G13_RS07935 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) A4G13_RS07945 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) A4G13_RS07950 ENOG4105E98 transcriptional regulator DeoR family A4G13_RS07955 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) A4G13_RS07980 ENOG4105CS9 pantothenic acid kinase A4G13_RS07985 ENOG4105KME endoribonuclease L-psp A4G13_RS07990 ENOG4105C0A alcohol dehydrogenase A4G13_RS08005 ENOG4105CRQ synthase (Component I) A4G13_RS08010 ENOG4105DDQ anthranilate synthase A4G13_RS08015 ENOG4105C1A potassium transporter peripheral membrane A4G13_RS08020 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) A4G13_RS08025 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) A4G13_RS08035 ENOG4108YZY peptidylprolyl cis-trans isomerase A4G13_RS08040 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A4G13_RS08045 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) A4G13_RS08050 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A4G13_RS08055 ENOG4105CE4 GlcNAc 6-P deacetylase A4G13_RS08060 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) A4G13_RS08065 ENOG4108R66 Conserved Protein A4G13_RS08070 ENOG4105BZM domain protein A4G13_RS08075 ENOG4108RRZ Transcription elongation factor GreB A4G13_RS08100 ENOG4105D7W serine acetyltransferase A4G13_RS08105 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase A4G13_RS08110 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) A4G13_RS08115 ENOG4107YZP Rhodanese domain protein A4G13_RS08120 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter A4G13_RS08125 ENOG4105C7B Threonine dehydratase A4G13_RS08130 ENOG4105C01 Dihydroxy-acid dehydratase A4G13_RS08135 ENOG4105F0N pyrophosphate phospho-hydrolase A4G13_RS08150 ENOG4105DQF Hydrolase A4G13_RS08155 ENOG4107Z6W Protein CrcB homolog A4G13_RS08160 ENOG4105Y75 tpr repeat protein A4G13_RS08165 ENOG4105EMN RNA polymerase sigma factor A4G13_RS08170 ENOG41069PW sigma-e factor negative regulatory protein A4G13_RS08175 ENOG4105VQK sigma E regulatory protein, MucB RseB A4G13_RS08180 ENOG4105WMJ Positive regulator of sigma E, RseC MucC A4G13_RS08185 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) A4G13_RS08190 ENOG4105MJ2 Competence protein A4G13_RS08195 ENOG4108X4Q Hydrolase A4G13_RS08200 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain A4G13_RS08205 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A4G13_RS08210 ENOG410903C (LipO)protein A4G13_RS08215 ENOG4105XWI UPF0304 protein A4G13_RS08225 ENOG4105Y3E Modulates RecA activity (By similarity) A4G13_RS08230 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) A4G13_RS08235 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) A4G13_RS08245 ENOG4106YJS accessory processing protein A4G13_RS08250 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) A4G13_RS08255 ENOG4108V62 Rhodanese domain protein A4G13_RS08260 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A4G13_RS08265 ENOG4105QTB Flavodoxin A4G13_RS08275 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) A4G13_RS08280 ENOG4105CBT Fructose-1,6-bisphosphatase A4G13_RS08290 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A4G13_RS08295 ENOG4105D16 lipopolysaccharide heptosyltransferase i A4G13_RS08305 ENOG4105XA0 heptosyltransferase ii A4G13_RS08310 ENOG4105KZW UPF0381 protein A4G13_RS08315 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) A4G13_RS08320 ENOG4105VEJ Heat shock protein A4G13_RS08325 ENOG4108IQE Amp-dependent synthetase and ligase A4G13_RS08330 ENOG4108K5P (LipO)protein A4G13_RS08340 ENOG4108UM1 dedA family A4G13_RS08345 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) A4G13_RS08350 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) A4G13_RS08355 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) A4G13_RS08360 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) A4G13_RS08365 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) A4G13_RS08370 ENOG4105CUW cytochrome C-TYPE protein A4G13_RS08375 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) A4G13_RS08380 ENOG4105GXZ Ferredoxin-type protein NapH A4G13_RS08385 ENOG4108BGM Quinol dehydrogenase periplasmic component A4G13_RS08390 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) A4G13_RS08405 ENOG4105CXY transporter A4G13_RS08410 ENOG4108KX4 response regulator A4G13_RS08415 ENOG4105BZU Histidine kinase A4G13_RS08420 ENOG4105CXY transporter A4G13_RS08425 ENOG4105BZU Histidine kinase A4G13_RS08435 ENOG4105CJP fad dependent oxidoreductase A4G13_RS08440 ENOG4107RUE extracellular solute-binding protein family 1 A4G13_RS08445 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase A4G13_RS08455 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A4G13_RS08495 ENOG4105C8J )-transporter A4G13_RS08505 ENOG4105DAS pts system A4G13_RS08510 ENOG4105ETZ PTS System A4G13_RS08515 ENOG4105F3R pts system mannose fructose sorbose family iid A4G13_RS08525 ENOG4105T16 Transcriptional regulator (AraC family) A4G13_RS08530 ENOG4108HWW ABC transporter A4G13_RS08535 ENOG4105C2J ABC transporter A4G13_RS08540 ENOG4105DFW ABC transporter A4G13_RS08545 ENOG4105C93 Xylose Isomerase A4G13_RS08550 ENOG4105CMG Carbohydrate kinase A4G13_RS08555 ENOG4105BZN citrate synthase A4G13_RS08560 ENOG4108HMX isocitrate dehydrogenase (NADP) A4G13_RS08565 ENOG4107QIJ Aconitate hydratase 2 A4G13_RS08570 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) A4G13_RS08575 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) A4G13_RS08580 ENOG4105E3S small subunit A4G13_RS08585 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein A4G13_RS08590 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit A4G13_RS08595 ENOG4105DPX Hydrogenase, large subunit A4G13_RS08600 ENOG4108USZ hydrogenase A4G13_RS08605 ENOG4108WGS hydrogenase 2-specific chaperone A4G13_RS08615 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) A4G13_RS08620 ENOG4108R3E Dna-3-methyladenine glycosylase i A4G13_RS08625 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A4G13_RS08630 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) A4G13_RS08635 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) A4G13_RS08645 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) A4G13_RS08650 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A4G13_RS08655 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A4G13_RS08660 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A4G13_RS08665 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) A4G13_RS08670 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A4G13_RS08675 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) A4G13_RS08680 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) A4G13_RS08685 ENOG410667J hydrolase A4G13_RS08695 ENOG4108R99 pseudouridine synthase A4G13_RS08705 ENOG4105R3P Inner membrane protein yagU A4G13_RS08710 ENOG4105EM7 Selenocysteine-specific translation elongation factor A4G13_RS08715 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) A4G13_RS08725 ENOG4107QY8 reductase A4G13_RS08730 ENOG4105QAX Iron-sulfur A4G13_RS08735 ENOG4107KGK dmso reductase anchor subunit A4G13_RS08740 ENOG4108NEM leader-binding protein dmsD A4G13_RS08745 ENOG4105N1P Ferredoxin-type protein A4G13_RS08755 ENOG4105C31 Tryptophanyl-tRNA synthetase A4G13_RS08760 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A4G13_RS08765 ENOG4105DJV ribulose-phosphate 3-epimerase A4G13_RS08770 ENOG4105DET Rhamnulokinase A4G13_RS08775 ENOG4105DKG l-rhamnose isomerase A4G13_RS08780 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) A4G13_RS08785 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) A4G13_RS08790 ENOG4105C0A alcohol dehydrogenase A4G13_RS08795 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) A4G13_RS08800 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) A4G13_RS08805 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) A4G13_RS08810 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) A4G13_RS08815 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A4G13_RS08820 ENOG41063SB peptidase A4G13_RS08825 ENOG4105PXI polysaccharide deacetylase A4G13_RS08830 ENOG4108I5U Uridine phosphorylase A4G13_RS08840 ENOG410804X Transcriptional regulator A4G13_RS08845 ENOG4105F9E Shikimate 5-dehydrogenase A4G13_RS08855 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate A4G13_RS08865 ENOG4105CJ3 phosphate transporter A4G13_RS08870 ENOG4107IX6 phosphate transport regulator A4G13_RS08875 ENOG4105I7R Adenylate cyclase A4G13_RS08880 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) A4G13_RS08915 ENOG4105KT7 mgtC SapB transporter A4G13_RS08920 ENOG4108EUD Lysophospholipase A4G13_RS08925 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A4G13_RS08930 ENOG4105CRP Part of the ABC transporter FtsEX involved in A4G13_RS08935 ENOG4105CAK Cell division ATP-binding protein ftsE A4G13_RS08945 ENOG4108YYH Nadph-dependent fmn reductase A4G13_RS08955 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) A4G13_RS08965 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) A4G13_RS08970 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A4G13_RS08975 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase A4G13_RS08985 ENOG4107RK2 ADP-ribose diphosphatase NudE A4G13_RS08995 ENOG4106ETB IIa component A4G13_RS09015 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A4G13_RS09020 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein A4G13_RS09030 ENOG4105D4A Cell wall formation (By similarity) A4G13_RS09035 ENOG4105D6U Sodium Glutamate Symporter A4G13_RS09040 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) A4G13_RS09045 ENOG4107S2Z UPF0761 membrane protein A4G13_RS09050 ENOG4105K5B UPF0225 protein A4G13_RS09055 ENOG4105D7A ATP-binding protein A4G13_RS09060 ENOG4108VVK transcriptional Regulator, AsnC A4G13_RS09065 ENOG4105CU9 asparagine synthetase A A4G13_RS09070 ENOG4105D9Q decarboxylase (Beta subunit) A4G13_RS09075 ENOG4107QSA Oxaloacetate decarboxylase A4G13_RS09085 ENOG4105C79 DNA protecting protein DprA A4G13_RS09090 ENOG4105EMY transcriptional regulator A4G13_RS09095 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A4G13_RS09100 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase A4G13_RS09105 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase A4G13_RS09110 ENOG4105CMG Carbohydrate kinase A4G13_RS09115 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A4G13_RS09120 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A4G13_RS09125 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A4G13_RS09130 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter A4G13_RS09135 ENOG4108R66 Conserved Protein A4G13_RS09140 ENOG4105DG4 malate L-lactate dehydrogenase A4G13_RS09145 ENOG41069M3 Transcriptional regulator A4G13_RS09155 ENOG4105CV1 Transketolase (EC 2.2.1.1) A4G13_RS09160 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) A4G13_RS09175 ENOG4105CNN ABC, transporter A4G13_RS09180 ENOG4105C2J ABC transporter A4G13_RS09185 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator A4G13_RS09190 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic A4G13_RS09195 ENOG4107S2N Type III effector Hrp-dependent A4G13_RS09200 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) A4G13_RS09205 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A4G13_RS09210 ENOG4105C0A alcohol dehydrogenase A4G13_RS09225 ENOG4105XEP YhcH YjgK YiaL family protein A4G13_RS09240 ENOG4105MVE transcriptional regulator A4G13_RS09245 ENOG4105CGY Dna recombination protein A4G13_RS09250 ENOG4108WI1 Dna topoisomerase A4G13_RS09255 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A4G13_RS09260 ENOG4105E2X shikimate dehydrogenase A4G13_RS09275 ENOG4105EEQ Na H antiporter A4G13_RS09280 ENOG4105C5H ABC transporter A4G13_RS09285 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein A4G13_RS09290 ENOG4106H78 methyltransferase A4G13_RS09295 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A4G13_RS09300 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b A4G13_RS09305 ENOG4105ECR NmrA family A4G13_RS09310 ENOG4105KVH Transcriptional regulator A4G13_RS09325 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) A4G13_RS09335 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia A4G13_RS09350 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) A4G13_RS09355 ENOG4105EJ2 Transcriptional regulator A4G13_RS09360 ENOG4105C5Q Transcriptional regulator A4G13_RS09365 ENOG4105EHV domain protein A4G13_RS09370 ENOG4105VRX Protein slyX homolog A4G13_RS09375 ENOG4108V1T peptidylprolyl cis-trans isomerase A4G13_RS09380 ENOG4105WWK YheO domain protein A4G13_RS09385 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) A4G13_RS09390 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) A4G13_RS09400 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) A4G13_RS09405 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) A4G13_RS09410 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) A4G13_RS09415 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) A4G13_RS09420 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) A4G13_RS09425 ENOG4108VVQ metallophosphoesterase A4G13_RS09430 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase A4G13_RS09435 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A4G13_RS09440 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) A4G13_RS09445 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein A4G13_RS09450 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) A4G13_RS09455 ENOG4108RR8 protoporphyrinogen oxidase A4G13_RS09480 ENOG4105W1Y Transcriptional regulator A4G13_RS09490 ENOG4105CEP NADH dehydrogenase A4G13_RS09495 ENOG4105E09 nadh pyrophosphatase A4G13_RS09500 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A4G13_RS09505 ENOG4105R2J Conserved Protein A4G13_RS09510 ENOG4105K70 DNA-binding protein A4G13_RS09515 ENOG410804X Transcriptional regulator A4G13_RS09520 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A4G13_RS09525 ENOG4107RGD Major Facilitator superfamily A4G13_RS09530 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) A4G13_RS09535 ENOG4107XDY Nicotinamide Mononucleotide Transporter A4G13_RS09540 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) A4G13_RS09545 ENOG4105D82 Glutamate dehydrogenase A4G13_RS09550 ENOG4108RVA ribokinase A4G13_RS09555 ENOG4106KNT transcriptional regulator A4G13_RS09560 ENOG4105CNN ABC, transporter A4G13_RS09565 ENOG4105C2J ABC transporter A4G13_RS09580 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) A4G13_RS09585 ENOG4105PM1 preprotein translocase subunit SecE A4G13_RS09590 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A4G13_RS09595 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) A4G13_RS09600 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) A4G13_RS09605 ENOG4108VZM 50s ribosomal protein L10 A4G13_RS09610 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A4G13_RS09615 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A4G13_RS09620 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A4G13_RS09625 ENOG4106RHG Yeca family A4G13_RS09630 ENOG4108JA2 transcriptioN-repair coupling factor A4G13_RS09640 ENOG4105E5Z arginine transporter ATP-binding subunit A4G13_RS09645 ENOG4106PMH Extracellular solute-binding protein family 3 A4G13_RS09650 ENOG4105GBT ABC transporter A4G13_RS09655 ENOG4105DMR ABC, transporter A4G13_RS09660 ENOG4105CA0 peroxidase A4G13_RS09665 ENOG4105C2M dna polymerase I A4G13_RS09670 ENOG4105C94 Transporter A4G13_RS09675 ENOG4105D4P Coproporphyrinogen iii oxidase A4G13_RS09680 ENOG4105XCT Protein of unknown function (DUF2489) A4G13_RS09685 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) A4G13_RS09690 ENOG4105D3G Pseudouridine synthase A4G13_RS09695 ENOG4105CWC Acetylornithine deacetylase A4G13_RS09700 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase A4G13_RS09705 ENOG4105CAS nag kinase A4G13_RS09710 ENOG4105CH7 arginosuccinase A4G13_RS09715 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) A4G13_RS09720 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) A4G13_RS09725 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A4G13_RS09730 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A4G13_RS09735 ENOG41080IJ Diacylglycerol kinase A4G13_RS09740 ENOG4105PF3 O-Antigen polymerase A4G13_RS09745 ENOG4105D2N Aldolase A4G13_RS09750 ENOG4105BZA Phosphoglycerate kinase A4G13_RS09755 ENOG41083KI ribonuclease, T2 A4G13_RS09760 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding A4G13_RS09765 ENOG4105EIB trna rrna methyltransferase A4G13_RS09770 ENOG4105JIM Phosphatidylserine synthase A4G13_RS09775 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) A4G13_RS09780 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) A4G13_RS09785 ENOG4105DSJ YicC domain protein A4G13_RS09790 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) A4G13_RS09795 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) A4G13_RS09800 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) A4G13_RS09815 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) A4G13_RS09820 ENOG4108UJU UPF0301 protein A4G13_RS09825 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) A4G13_RS09830 ENOG4105C5F glutamine synthetase A4G13_RS09835 ENOG4105CI3 gtp-binding protein typa A4G13_RS09840 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A4G13_RS09850 ENOG4107YB6 acetyltransferase, (GNAT) family A4G13_RS09865 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) A4G13_RS09870 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) A4G13_RS09875 ENOG410601J HemY protein A4G13_RS09880 ENOG4105ECF c-methyltransferase A4G13_RS09890 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) A4G13_RS09895 ENOG4107T0K Adenylate cyclase A4G13_RS09900 ENOG4105WH1 Two component transcriptional regulator luxr family A4G13_RS09905 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) A4G13_RS09910 ENOG4105C2J ABC transporter A4G13_RS09915 ENOG4105CNN ABC, transporter A4G13_RS09920 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A4G13_RS09925 ENOG4108RVA ribokinase A4G13_RS09930 ENOG4105ETE Transcriptional regulator (LacI family A4G13_RS09935 ENOG4105CFU surface antigen A4G13_RS09940 ENOG4105MA0 exported protein A4G13_RS09945 ENOG4105C9X ppx gppa phosphatase A4G13_RS09950 ENOG4105D0C transport protein A4G13_RS09955 ENOG4105CQ0 ABC transporter A4G13_RS09960 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) A4G13_RS09965 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A4G13_RS09970 ENOG4105DSQ Nitric oxide reductase A4G13_RS09985 ENOG4107QTF adenylosuccinate lyase A4G13_RS09990 ENOG41075W9 High frequency lysogenization protein HflD homolog A4G13_RS09995 ENOG4105KEG ribosomal-protein-alanine acetyltransferase A4G13_RS10000 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A4G13_RS10010 ENOG4105CJ2 (LipO)protein A4G13_RS10015 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) A4G13_RS10020 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) A4G13_RS10025 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) A4G13_RS10030 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) A4G13_RS10040 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) A4G13_RS10045 ENOG4105M85 Bola protein A4G13_RS10050 ENOG4105IEY (LipO)protein A4G13_RS10070 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division A4G13_RS10075 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) A4G13_RS10080 ENOG4105CEN a g-specific adenine glycosylase A4G13_RS10085 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) A4G13_RS10090 ENOG41090ED Protein with unknown function (DUF469) A4G13_RS10095 ENOG4107QUT magnesium and cobalt transport protein CorA A4G13_RS10100 ENOG4108VIA integral membrane protein A4G13_RS10105 ENOG4105VZ9 UPF0235 protein A4G13_RS10110 ENOG4108HYK gCN5-related N-acetyltransferase A4G13_RS10130 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A4G13_RS10135 ENOG4105M6F mutator MutT protein A4G13_RS10150 ENOG4105H1G trap transporter solute receptor taxi family A4G13_RS10155 ENOG4105DJF DNA polymerase III, delta' subunit A4G13_RS10165 ENOG4105C8T Leucyl-tRNA synthetase A4G13_RS10195 ENOG410681U heavy metal transport detoxification protein A4G13_RS10205 ENOG4108KS2 transglutaminase domain protein A4G13_RS10210 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) A4G13_RS10215 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A4G13_RS10225 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) A4G13_RS10230 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A4G13_RS10235 ENOG4108M6U Universal stress protein A A4G13_RS10240 ENOG4105DXN mazG family A4G13_RS10245 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA A4G13_RS10250 ENOG4105BZG amino acid carrier protein A4G13_RS10260 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) A4G13_RS10265 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A4G13_RS10270 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) A4G13_RS10275 ENOG4105D7Q type ii secretion system A4G13_RS10280 ENOG4107QHF type ii secretion system protein e A4G13_RS10290 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase A4G13_RS10305 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) A4G13_RS10310 ENOG4105C3F Signal peptidase i A4G13_RS10315 ENOG4105C3F Signal peptidase i A4G13_RS10320 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) A4G13_RS10325 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) A4G13_RS10330 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) A4G13_RS10335 ENOG4105D1Q UPF0246 protein A4G13_RS10345 ENOG41076HS cation diffusion facilitator family transporter A4G13_RS10350 ENOG4105CTQ phosphohexokinase A4G13_RS10365 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) A4G13_RS10370 ENOG4105G63 Type III effector Hrp-dependent A4G13_RS10375 ENOG4108YZG isomerase A4G13_RS10380 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) A4G13_RS10390 ENOG4105CI3 gtp-binding protein typa A4G13_RS10395 ENOG4105DIJ Phosphoethanolamine transferase A4G13_RS10400 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A4G13_RS10405 ENOG4105C6K Malic enzyme A4G13_RS10410 ENOG4105I08 Pseudouridine synthase A4G13_RS10415 ENOG4105C2C drug resistance transporter, Bcr CflA A4G13_RS10425 ENOG4105BZ1 (ABC) transporter A4G13_RS10435 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) A4G13_RS10445 ENOG4105K59 histidine triad (HIT) protein A4G13_RS10450 ENOG4105TMB Formate nitrite transporter A4G13_RS10455 ENOG4105C6N Formate acetyltransferase A4G13_RS10460 ENOG4105F1A Pyruvate formate-lyase A4G13_RS10465 ENOG4108Z6B deaminase A4G13_RS10470 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) A4G13_RS10475 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) A4G13_RS10480 ENOG4105HF0 Membrane A4G13_RS10485 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) A4G13_RS10490 ENOG4105E61 Mannitol repressor protein A4G13_RS10495 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase