locus-tag	class	description
A4G13_RS00010	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4G13_RS00020	COG1464	Belongs to the NlpA lipoprotein family
A4G13_RS00030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4G13_RS00035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4G13_RS00075	COG4783	chaperone-mediated protein folding
A4G13_RS00080	COG0463	Glycosyl transferase, family 2
A4G13_RS00085	COG0859	PFAM glycosyl transferase family 9
A4G13_RS00090	COG0228	four-way junction DNA binding
A4G13_RS00095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4G13_RS00100	COG0336	Belongs to the RNA methyltransferase TrmD family
A4G13_RS00105	COG0335	large ribosomal subunit rRNA binding
A4G13_RS00120	COG3306	glycosyltransferase involved in LPS biosynthesis
A4G13_RS00125	COG1442	glycosyl transferase family 8
A4G13_RS00130	COG0254	rRNA binding
A4G13_RS00135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4G13_RS00140	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4G13_RS00145	COG1309	transcriptional regulator
A4G13_RS00150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G13_RS00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4G13_RS00165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4G13_RS00170	COG0459	protein refolding
A4G13_RS00175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4G13_RS00180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G13_RS00185	COG1124	(ABC) transporter
A4G13_RS00195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G13_RS00200	COG0601	transmembrane transport
A4G13_RS00205	COG0747	negative chemotaxis
A4G13_RS00210	COG2226	methyltransferase
A4G13_RS00215	COG0789	Transcriptional regulator
A4G13_RS00220	COG0360	Binds together with S18 to 16S ribosomal RNA
A4G13_RS00225	COG2965	DNA replication, synthesis of RNA primer
A4G13_RS00230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4G13_RS00235	COG0359	binds to the 23S rRNA
A4G13_RS00240	COG0557	exoribonuclease II activity
A4G13_RS00245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G13_RS00250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4G13_RS00260	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A4G13_RS00270	COG0006	proline dipeptidase activity
A4G13_RS00275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4G13_RS00280	COG0706	membrane insertase activity
A4G13_RS00285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4G13_RS00290	COG0594	ribonuclease P activity
A4G13_RS00300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4G13_RS00305	COG0592	DNA-directed DNA polymerase activity
A4G13_RS00310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4G13_RS00315	COG1114	Component of the transport system for branched-chain amino acids
A4G13_RS00345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4G13_RS00355	COG1185	polyribonucleotide nucleotidyltransferase activity
A4G13_RS00360	COG4785	May be involved in cell division
A4G13_RS00365	COG0513	Belongs to the DEAD box helicase family
A4G13_RS00370	COG0659	secondary active sulfate transmembrane transporter activity
A4G13_RS00380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4G13_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G13_RS00395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G13_RS00400	COG0805	protein transport
A4G13_RS00415	COG3266	domain, Protein
A4G13_RS00415	COG3061	Opacity-associated protein A
A4G13_RS00420	COG1509	lysine 2,3-aminomutase activity
A4G13_RS00425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4G13_RS00430	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G13_RS00435	COG0204	Acyl-transferase
A4G13_RS00440	COG2132	Multicopper oxidase
A4G13_RS00445	COG1811	Na channel or pump
A4G13_RS00455	COG0848	biopolymer transport protein
A4G13_RS00460	COG0811	peptide transport
A4G13_RS00465	COG4771	TonB-dependent receptor
A4G13_RS00470	COG4536	flavin adenine dinucleotide binding
A4G13_RS00475	COG4137	Cytochrome C assembly protein
A4G13_RS00480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4G13_RS00485	COG0385	Bile acid
A4G13_RS00490	COG1011	Hydrolase
A4G13_RS00495	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A4G13_RS00515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G13_RS00530	COG2721	sulfolactate sulfo-lyase activity
A4G13_RS00535	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A4G13_RS00545	COG2264	protein methyltransferase activity
A4G13_RS00555	COG1312	Catalyzes the dehydration of D-mannonate
A4G13_RS00560	COG2186	Transcriptional regulator
A4G13_RS00575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4G13_RS00585	COG1028	Short-chain dehydrogenase reductase Sdr
A4G13_RS00590	COG1904	glucuronate isomerase
A4G13_RS00595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G13_RS00600	COG0800	Aldolase
A4G13_RS00605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4G13_RS00610	COG4175	Glycine betaine
A4G13_RS00615	COG4176	ABC-type proline glycine betaine transport system permease component
A4G13_RS00620	COG2113	Glycine betaine
A4G13_RS00625	COG0531	amino acid
A4G13_RS00640	COG0193	aminoacyl-tRNA hydrolase activity
A4G13_RS00650	COG2914	Belongs to the UPF0125 (RnfH) family
A4G13_RS00655	COG2850	peptidyl-arginine hydroxylation
A4G13_RS00665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4G13_RS00670	COG1414	Transcriptional regulator
A4G13_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
A4G13_RS00685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G13_RS00690	COG0800	Aldolase
A4G13_RS00695	COG1917	Cupin 2, conserved barrel domain protein
A4G13_RS00700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4G13_RS00705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4G13_RS00710	COG0470	DNA polymerase III
A4G13_RS00715	COG0084	hydrolase, TatD family'
A4G13_RS00725	COG1253	flavin adenine dinucleotide binding
A4G13_RS00740	COG2315	Protein conserved in bacteria
A4G13_RS00750	COG1349	DNA-binding transcription factor activity
A4G13_RS00755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G13_RS00760	COG2084	Dehydrogenase
A4G13_RS00765	COG3684	Belongs to the aldolase LacD family
A4G13_RS00770	COG1501	Belongs to the glycosyl hydrolase 31 family
A4G13_RS00810	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4G13_RS00815	COG1175	transmembrane transport
A4G13_RS00820	COG3842	ATPase activity
A4G13_RS00825	COG0629	single-stranded DNA binding
A4G13_RS00830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4G13_RS00835	COG3005	denitrification pathway
A4G13_RS00840	COG0243	molybdopterin cofactor binding
A4G13_RS00845	COG1077	Cell shape determining protein MreB Mrl
A4G13_RS00850	COG1792	Involved in formation and maintenance of cell shape
A4G13_RS00855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4G13_RS00860	COG0066	3-isopropylmalate dehydratase activity
A4G13_RS00865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4G13_RS00870	COG0473	3-isopropylmalate dehydrogenase activity
A4G13_RS00880	COG4133	protoheme IX ABC transporter activity
A4G13_RS00885	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G13_RS00890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G13_RS00895	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G13_RS00900	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A4G13_RS00905	COG1138	Cytochrome C-type biogenesis protein
A4G13_RS00925	COG0346	lactoylglutathione lyase activity
A4G13_RS00940	COG1482	cell wall glycoprotein biosynthetic process
A4G13_RS00950	COG3716	PTS system mannose fructose sorbose family IID component
A4G13_RS00955	COG3715	PTS system
A4G13_RS00960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS00960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G13_RS00965	COG2824	Alkylphosphonate utilization operon protein PhnA
A4G13_RS00970	COG0121	glutamine amidotransferase
A4G13_RS00975	COG0215	cysteine-tRNA ligase activity
A4G13_RS00985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4G13_RS00990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4G13_RS00995	COG0084	hydrolase, TatD family'
A4G13_RS01000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4G13_RS01005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4G13_RS01010	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A4G13_RS01015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4G13_RS01020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4G13_RS01025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4G13_RS01030	COG0602	queuosine metabolic process
A4G13_RS01035	COG1328	CTP reductase activity
A4G13_RS01035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4G13_RS01040	COG0861	Integral membrane protein TerC family
A4G13_RS01050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4G13_RS01060	COG1879	ABC-type sugar transport system periplasmic component
A4G13_RS01065	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4G13_RS01070	COG1129	ABC transporter
A4G13_RS01075	COG1879	ABC-type sugar transport system periplasmic component
A4G13_RS01080	COG1609	Transcriptional regulator
A4G13_RS01085	COG1085	galactose-1-phosphate uridylyltransferase
A4G13_RS01090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4G13_RS01095	COG2017	converts alpha-aldose to the beta-anomer
A4G13_RS01105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4G13_RS01115	COG1215	transferase activity, transferring glycosyl groups
A4G13_RS01115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G13_RS01120	COG1215	transferase activity, transferring glycosyl groups
A4G13_RS01120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4G13_RS01135	COG1216	Glycosyl transferase, family 2
A4G13_RS01155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4G13_RS01165	COG0105	UTP biosynthetic process
A4G13_RS01170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4G13_RS01175	COG0783	Belongs to the Dps family
A4G13_RS01180	COG0754	glutathionylspermidine amidase activity
A4G13_RS01185	COG1393	Belongs to the ArsC family
A4G13_RS01190	COG1943	Transposase
A4G13_RS01195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G13_RS01200	COG1876	peptidase activity
A4G13_RS01205	COG0352	thiamine-phosphate diphosphorylase activity
A4G13_RS01210	COG0351	phosphomethylpyrimidine kinase
A4G13_RS01220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4G13_RS01225	COG3028	Belongs to the UPF0307 family
A4G13_RS01230	COG0312	modulator of DNA gyrase
A4G13_RS01235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A4G13_RS01240	COG3386	PFAM SMP-30 Gluconolaconase
A4G13_RS01245	COG2610	gluconate transmembrane transporter activity
A4G13_RS01250	COG0656	L-ascorbic acid biosynthetic process
A4G13_RS01255	COG2610	gluconate transmembrane transporter activity
A4G13_RS01260	COG4948	Mandelate Racemase Muconate Lactonizing
A4G13_RS01270	COG2084	Dehydrogenase
A4G13_RS01275	COG1929	Belongs to the glycerate kinase type-1 family
A4G13_RS01280	COG3835	regulator
A4G13_RS01285	COG2721	sulfolactate sulfo-lyase activity
A4G13_RS01310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G13_RS01315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4G13_RS01330	COG2056	Na+-H+ antiporter family
A4G13_RS01335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4G13_RS01340	COG0346	lactoylglutathione lyase activity
A4G13_RS01350	COG4106	trans-aconitate 2-methyltransferase activity
A4G13_RS01355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4G13_RS01360	COG0494	nUDIX hydrolase
A4G13_RS01365	COG0217	transcriptional regulatory protein
A4G13_RS01370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4G13_RS01375	COG0632	four-way junction helicase activity
A4G13_RS01380	COG2255	four-way junction helicase activity
A4G13_RS01390	COG1271	oxidase subunit
A4G13_RS01395	COG1294	oxidase, subunit
A4G13_RS01405	COG3790	cyd operon protein YbgE
A4G13_RS01410	COG0824	Thioesterase
A4G13_RS01415	COG0811	peptide transport
A4G13_RS01420	COG0848	biopolymer transport protein
A4G13_RS01425	COG3064	Membrane
A4G13_RS01430	COG0823	Involved in the tonB-independent uptake of proteins
A4G13_RS01455	COG2165	general secretion pathway protein
A4G13_RS01460	COG4795	General secretion pathway protein
A4G13_RS01475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A4G13_RS01485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4G13_RS01490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4G13_RS01500	COG3383	formate dehydrogenase (NAD+) activity
A4G13_RS01510	COG2350	Protein conserved in bacteria
A4G13_RS01515	COG1607	acyl-coa hydrolase
A4G13_RS01520	COG2917	probably involved in intracellular septation
A4G13_RS01530	COG3047	cAMP biosynthetic process
A4G13_RS01535	COG0497	DNA recombination
A4G13_RS01540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4G13_RS01550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4G13_RS01555	COG2937	Belongs to the GPAT DAPAT family
A4G13_RS01560	COG4974	Belongs to the 'phage' integrase family
A4G13_RS01565	COG0116	Belongs to the methyltransferase superfamily
A4G13_RS01565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4G13_RS01570	COG5295	Hep Hag repeat protein
A4G13_RS01570	COG5295	Hep Hag repeat protein
A4G13_RS01580	COG1556	Lactate utilization protein
A4G13_RS01585	COG1139	Iron-sulfur cluster binding protein
A4G13_RS01590	COG0247	lactate metabolic process
A4G13_RS01595	COG1620	l-lactate permease
A4G13_RS01600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4G13_RS01600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4G13_RS01605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4G13_RS01615	COG0189	ligase activity
A4G13_RS01625	COG2268	Band 7 protein
A4G13_RS01640	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A4G13_RS01645	COG0583	DNA-binding transcription factor activity
A4G13_RS01650	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4G13_RS01655	COG1687	branched-chain amino acid
A4G13_RS01660	COG1115	amino acid carrier protein
A4G13_RS01665	COG0825	malonyl-CoA metabolic process
A4G13_RS01670	COG3955	Domain of unknown function (DUF1919)
A4G13_RS01675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G13_RS01680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4G13_RS01680	COG0519	Catalyzes the synthesis of GMP from XMP
A4G13_RS01690	COG0517	IMP dehydrogenase activity
A4G13_RS01690	COG0516	GMP reductase activity
A4G13_RS01695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4G13_RS01695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4G13_RS01700	COG0500	methyltransferase
A4G13_RS01705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G13_RS01710	COG1530	ribonuclease E activity
A4G13_RS01740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4G13_RS01745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G13_RS01750	COG1121	(ABC) transporter
A4G13_RS01755	COG0739	heme binding
A4G13_RS01760	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G13_RS01765	COG4605	iron ion homeostasis
A4G13_RS01770	COG4604	ABC transporter, ATP-binding protein
A4G13_RS01780	COG0563	adenylate kinase activity
A4G13_RS01785	COG2814	Major facilitator Superfamily
A4G13_RS01790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4G13_RS01795	COG3152	Membrane
A4G13_RS01805	COG2252	PERMEase
A4G13_RS01815	COG0037	tRNA processing
A4G13_RS01820	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A4G13_RS01835	COG2223	nitrite transmembrane transporter activity
A4G13_RS01845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4G13_RS01850	COG1177	transmembrane transport
A4G13_RS01855	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4G13_RS01860	COG3842	ATPase activity
A4G13_RS01870	COG3008	intermembrane lipid transfer
A4G13_RS01875	COG2995	paraquat-inducible protein a
A4G13_RS01880	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A4G13_RS01885	COG0793	Belongs to the peptidase S41A family
A4G13_RS01890	COG2989	Protein conserved in bacteria
A4G13_RS01895	COG3108	Peptidase M15
A4G13_RS01900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G13_RS01910	COG0076	glutamate decarboxylase activity
A4G13_RS01915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4G13_RS01930	COG2932	Transcriptional regulator
A4G13_RS01935	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A4G13_RS01940	COG1119	ATPase activity
A4G13_RS01945	COG0330	HflC and HflK could
A4G13_RS01955	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4G13_RS01960	COG3381	protein complex oligomerization
A4G13_RS01965	COG3304	Inner membrane component domain
A4G13_RS01970	COG1803	Methylglyoxal synthase
A4G13_RS02020	COG0561	phosphatase activity
A4G13_RS02030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A4G13_RS02035	COG1254	Belongs to the acylphosphatase family
A4G13_RS02040	COG2920	part of a sulfur-relay system
A4G13_RS02045	COG0670	Belongs to the BI1 family
A4G13_RS02055	COG1686	Belongs to the peptidase S11 family
A4G13_RS02060	COG4172	Belongs to the ABC transporter superfamily
A4G13_RS02065	COG4172	Belongs to the ABC transporter superfamily
A4G13_RS02070	COG4171	peptide transport system, permease
A4G13_RS02075	COG4168	peptide transport system, permease
A4G13_RS02080	COG4166	transmembrane transport
A4G13_RS02085	COG3106	COG3106 Predicted ATPase
A4G13_RS02090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G13_RS02095	COG0735	belongs to the Fur family
A4G13_RS02100	COG0716	FMN binding
A4G13_RS02110	COG0596	Alpha beta hydrolase
A4G13_RS02115	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A4G13_RS02120	COG0318	PFAM AMP-dependent synthetase and ligase
A4G13_RS02125	COG3264	Mechanosensitive ion channel
A4G13_RS02125	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A4G13_RS02130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4G13_RS02135	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A4G13_RS02140	COG0730	response to heat
A4G13_RS02145	COG1560	Kdo2-lipid A biosynthetic process
A4G13_RS02150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4G13_RS02155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4G13_RS02160	COG3021	interspecies interaction between organisms
A4G13_RS02175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G13_RS02185	COG0187	DNA topoisomerase II activity
A4G13_RS02190	COG0385	Bile acid
A4G13_RS02195	COG2267	carboxylic ester hydrolase activity
A4G13_RS02200	COG1979	alcohol dehydrogenase
A4G13_RS02205	COG0583	DNA-binding transcription factor activity
A4G13_RS02220	COG2217	Heavy metal translocating P-type atpase
A4G13_RS02225	COG2217	Heavy metal translocating P-type atpase
A4G13_RS02230	COG2864	formate dehydrogenase
A4G13_RS02235	COG0437	4 iron, 4 sulfur cluster binding
A4G13_RS02245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4G13_RS02250	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A4G13_RS02255	COG0583	DNA-binding transcription factor activity
A4G13_RS02260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G13_RS02265	COG5339	Protein conserved in bacteria
A4G13_RS02270	COG0443	Heat shock 70 kDa protein
A4G13_RS02275	COG0484	heat shock protein binding
A4G13_RS02285	COG2951	lytic endotransglycosylase activity
A4G13_RS02290	COG1216	Glycosyl transferase, family 2
A4G13_RS02295	COG1216	Glycosyl transferase, family 2
A4G13_RS02305	COG3306	glycosyltransferase involved in LPS biosynthesis
A4G13_RS02315	COG5039	Polysaccharide pyruvyl transferase
A4G13_RS02320	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4G13_RS02330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4G13_RS02345	COG0733	neurotransmitter:sodium symporter activity
A4G13_RS02350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4G13_RS02365	COG4658	electron transport chain
A4G13_RS02370	COG4656	Part of a membrane complex involved in electron transport
A4G13_RS02380	COG4657	Part of a membrane complex involved in electron transport
A4G13_RS02385	COG2949	membrane
A4G13_RS02390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4G13_RS02395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4G13_RS02400	COG0617	tRNA 3'-terminal CCA addition
A4G13_RS02410	COG2333	competence protein COMEC
A4G13_RS02410	COG0658	competence protein
A4G13_RS02415	COG1132	(ABC) transporter
A4G13_RS02420	COG1663	tetraacyldisaccharide 4'-kinase activity
A4G13_RS02425	COG2835	tetraacyldisaccharide 4'-kinase activity
A4G13_RS02430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4G13_RS02440	COG0322	excinuclease ABC activity
A4G13_RS02445	COG1793	dna ligase
A4G13_RS02450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4G13_RS02455	COG2354	Protein conserved in bacteria
A4G13_RS02460	COG1944	ATP diphosphatase activity
A4G13_RS02470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G13_RS02475	COG2837	iron assimilation
A4G13_RS02480	COG1946	Acyl-CoA thioesterase
A4G13_RS02490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4G13_RS02495	COG4988	ABC transporter
A4G13_RS02500	COG0492	ferredoxin-NADP+ reductase activity
A4G13_RS02505	COG3118	belongs to the thioredoxin family
A4G13_RS02510	COG2610	gluconate transmembrane transporter activity
A4G13_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
A4G13_RS02520	COG1063	alcohol dehydrogenase
A4G13_RS02525	COG3265	gluconokinase activity
A4G13_RS02535	COG3209	COG3209 Rhs family protein
A4G13_RS02535	COG4104	PAAR repeat-containing protein
A4G13_RS02550	COG1741	Belongs to the pirin family
A4G13_RS02565	COG4772	TonB-dependent receptor
A4G13_RS02580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4G13_RS02585	COG2027	D-alanyl-D-alanine carboxypeptidase
A4G13_RS02590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4G13_RS02595	COG1534	Rna-binding protein
A4G13_RS02600	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A4G13_RS02605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4G13_RS02610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4G13_RS02615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G13_RS02620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G13_RS02625	COG0633	Ferredoxin
A4G13_RS02630	COG0471	metal ion transport
A4G13_RS02635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4G13_RS02640	COG1280	lysine exporter protein (LysE YggA)
A4G13_RS02645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4G13_RS02650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4G13_RS02655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4G13_RS02660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4G13_RS02665	COG0814	amino acid
A4G13_RS02675	COG1518	maintenance of DNA repeat elements
A4G13_RS02715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G13_RS02720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G13_RS02725	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4G13_RS02730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4G13_RS02730	COG0517	IMP dehydrogenase activity
A4G13_RS02740	COG0857	belongs to the CobB CobQ family
A4G13_RS02740	COG0280	phosphate acetyltransferase
A4G13_RS02745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4G13_RS02755	COG1286	toxin biosynthetic process
A4G13_RS02765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4G13_RS02770	COG0303	'Molybdopterin
A4G13_RS02775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4G13_RS02780	COG1410	methionine synthase
A4G13_RS02780	COG0646	methionine synthase
A4G13_RS02785	COG1943	Transposase
A4G13_RS02800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G13_RS02810	COG4206	TonB-dependent receptor
A4G13_RS02815	COG3099	Belongs to the UPF0263 family
A4G13_RS02825	COG2252	PERMEase
A4G13_RS02830	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4G13_RS02840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4G13_RS02845	COG0315	cyclic pyranopterin monophosphate synthase activity
A4G13_RS02850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4G13_RS02855	COG0314	molybdopterin synthase activity
A4G13_RS02870	COG2864	formate dehydrogenase
A4G13_RS02875	COG0437	4 iron, 4 sulfur cluster binding
A4G13_RS02880	COG3383	formate dehydrogenase (NAD+) activity
A4G13_RS02880	COG0243	molybdopterin cofactor binding
A4G13_RS02890	COG2376	Dihydroxyacetone kinase
A4G13_RS02895	COG1461	Dihydroxyacetone kinase
A4G13_RS02905	COG2390	Transcriptional regulator
A4G13_RS02910	COG0698	ribose 5-phosphate isomerase
A4G13_RS02915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G13_RS02925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4G13_RS02940	COG1448	Aminotransferase
A4G13_RS02945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4G13_RS02950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4G13_RS02955	COG0308	aminopeptidase N
A4G13_RS02960	COG0167	dihydroorotate dehydrogenase activity
A4G13_RS02965	COG0613	PHP domain protein
A4G13_RS02970	COG0009	L-threonylcarbamoyladenylate synthase
A4G13_RS02980	COG0583	DNA-binding transcription factor activity
A4G13_RS02995	COG0017	Asparaginyl-tRNA synthetase
A4G13_RS03000	COG0302	gtp cyclohydrolase
A4G13_RS03015	COG3100	YcgL domain-containing protein
A4G13_RS03020	COG0708	Exodeoxyribonuclease III
A4G13_RS03025	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A4G13_RS03030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4G13_RS03040	COG2999	glutathione oxidoreductase activity
A4G13_RS03045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4G13_RS03070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4G13_RS03080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4G13_RS03085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4G13_RS03090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4G13_RS03100	COG0095	Lipoate-protein ligase
A4G13_RS03105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4G13_RS03110	COG0142	geranyltranstransferase activity
A4G13_RS03115	COG1722	exodeoxyribonuclease VII activity
A4G13_RS03120	COG0301	tRNA thio-modification
A4G13_RS03120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G13_RS03125	COG1609	Transcriptional regulator
A4G13_RS03130	COG0288	reversible hydration of carbon dioxide
A4G13_RS03135	COG1131	(ABC) transporter
A4G13_RS03140	COG0842	Transport permease protein
A4G13_RS03145	COG1611	Belongs to the LOG family
A4G13_RS03150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4G13_RS03150	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4G13_RS03155	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A4G13_RS03160	COG3098	single-species biofilm formation
A4G13_RS03170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4G13_RS03175	COG3140	Belongs to the UPF0181 family
A4G13_RS03180	COG0589	response to stress
A4G13_RS03185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4G13_RS03190	COG1528	Iron-storage protein
A4G13_RS03195	COG1528	Iron-storage protein
A4G13_RS03200	COG2925	Exonuclease
A4G13_RS03205	COG0697	spore germination
A4G13_RS03215	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A4G13_RS03220	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A4G13_RS03225	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A4G13_RS03230	COG0037	tRNA processing
A4G13_RS03235	COG0791	NLP P60 protein
A4G13_RS03240	COG0776	regulation of translation
A4G13_RS03245	COG0072	phenylalanine-tRNA ligase activity
A4G13_RS03250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4G13_RS03255	COG3422	double-strand break repair
A4G13_RS03270	COG1278	Cold shock
A4G13_RS03275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4G13_RS03280	COG0583	DNA-binding transcription factor activity
A4G13_RS03285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4G13_RS03290	COG1074	ATP-dependent DNA helicase activity
A4G13_RS03295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4G13_RS03300	COG0287	Prephenate dehydrogenase
A4G13_RS03300	COG1605	Chorismate mutase
A4G13_RS03305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4G13_RS03310	COG0473	3-isopropylmalate dehydrogenase activity
A4G13_RS03315	COG0616	signal peptide processing
A4G13_RS03320	COG0778	Nitroreductase
A4G13_RS03325	COG3064	Membrane
A4G13_RS03325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4G13_RS03325	COG3583	domain protein
A4G13_RS03335	COG1215	transferase activity, transferring glycosyl groups
A4G13_RS03340	COG0726	polysaccharide deacetylase
A4G13_RS03340	COG1649	PFAM Uncharacterised BCR, COG1649
A4G13_RS03350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4G13_RS03355	COG0586	Pfam SNARE associated Golgi protein
A4G13_RS03365	COG0297	glycogen (starch) synthase activity
A4G13_RS03370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4G13_RS03375	COG1523	belongs to the glycosyl hydrolase 13 family
A4G13_RS03380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4G13_RS03385	COG1640	4-alpha-glucanotransferase
A4G13_RS03405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G13_RS03410	COG0577	efflux transmembrane transporter activity
A4G13_RS03410	COG1136	(ABC) transporter
A4G13_RS03415	COG1538	Outer membrane efflux protein
A4G13_RS03420	COG3101	peptidyl-lysine hydroxylation
A4G13_RS03425	COG0501	Belongs to the peptidase M48B family
A4G13_RS03430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4G13_RS03435	COG3593	DNA synthesis involved in DNA repair
A4G13_RS03440	COG2431	L-lysine efflux transmembrane transporter activity
A4G13_RS03450	COG2897	thiosulfate sulfurtransferase activity
A4G13_RS03455	COG2897	thiosulfate sulfurtransferase activity
A4G13_RS03460	COG2391	methyltransferase activity
A4G13_RS03475	COG0616	signal peptide processing
A4G13_RS03480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4G13_RS03485	COG0512	Glutamine amidotransferase of anthranilate synthase
A4G13_RS03490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4G13_RS03495	COG0134	indole-3-glycerol-phosphate synthase activity
A4G13_RS03495	COG0135	phosphoribosylanthranilate isomerase activity
A4G13_RS03500	COG0133	tryptophan synthase activity
A4G13_RS03505	COG0159	tryptophan synthase activity
A4G13_RS03525	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4G13_RS03555	COG3210	domain, Protein
A4G13_RS03565	COG2831	hemolysin activation secretion protein
A4G13_RS03570	COG0564	pseudouridine synthase activity
A4G13_RS03580	COG0406	alpha-ribazole phosphatase activity
A4G13_RS03585	COG0285	dihydrofolate synthase activity
A4G13_RS03590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4G13_RS03595	COG0101	tRNA pseudouridine synthase activity
A4G13_RS03600	COG2171	N-acyltransferase activity
A4G13_RS03610	COG2095	MarC family integral membrane protein
A4G13_RS03615	COG0166	Belongs to the GPI family
A4G13_RS03620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4G13_RS03625	COG0305	Participates in initiation and elongation during chromosome replication
A4G13_RS03630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4G13_RS03635	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G13_RS03640	COG1136	(ABC) transporter
A4G13_RS03645	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G13_RS03650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4G13_RS03655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A4G13_RS03670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4G13_RS03680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4G13_RS03685	COG1067	ATP-dependent peptidase activity
A4G13_RS03695	COG0469	pyruvate kinase activity
A4G13_RS03700	COG2062	phosphohistidine phosphatase, SixA
A4G13_RS03710	COG0339	signal peptide processing
A4G13_RS03715	COG1120	ATPase activity
A4G13_RS03730	COG4615	Cyclic peptide transporter
A4G13_RS03750	COG0656	L-ascorbic acid biosynthetic process
A4G13_RS03760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4G13_RS03760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4G13_RS03770	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4G13_RS03780	COG1704	LemA family
A4G13_RS03795	COG0277	FAD linked oxidase domain protein
A4G13_RS03795	COG0247	lactate metabolic process
A4G13_RS03805	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4G13_RS03810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4G13_RS03820	COG2211	Major facilitator Superfamily
A4G13_RS03825	COG2169	Transcriptional regulator
A4G13_RS03830	COG1489	DNA binding
A4G13_RS03835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4G13_RS03840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G13_RS03845	COG0366	Alpha amylase catalytic
A4G13_RS03850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G13_RS03850	COG1263	PTS System
A4G13_RS03855	COG1609	Transcriptional regulator
A4G13_RS03860	COG0488	(ABC) transporter
A4G13_RS03870	COG1609	Transcriptional regulator
A4G13_RS03875	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A4G13_RS03880	COG0642	Histidine kinase
A4G13_RS03885	COG0745	RESPONSE REGULATOR receiver
A4G13_RS03895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4G13_RS03900	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4G13_RS03905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4G13_RS03925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4G13_RS03925	COG1648	precorrin-2 dehydrogenase activity
A4G13_RS03935	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A4G13_RS03940	COG4208	sulfate ABC transporter
A4G13_RS03945	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4G13_RS03950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4G13_RS03950	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4G13_RS03955	COG1560	Kdo2-lipid A biosynthetic process
A4G13_RS03970	COG0039	L-malate dehydrogenase activity
A4G13_RS03975	COG1438	arginine binding
A4G13_RS03980	COG1090	epimerase
A4G13_RS03990	COG1346	cytolysis
A4G13_RS03995	COG1380	Effector of murein hydrolase LrgA
A4G13_RS04000	COG1525	nuclease
A4G13_RS04005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4G13_RS04010	COG2166	iron-sulfur cluster assembly
A4G13_RS04015	COG1126	abc transporter atp-binding protein
A4G13_RS04020	COG0765	amino acid transport
A4G13_RS04025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G13_RS04030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A4G13_RS04035	COG2969	positive regulation of protein catabolic process
A4G13_RS04045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4G13_RS04050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4G13_RS04060	COG3105	Protein conserved in bacteria
A4G13_RS04065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4G13_RS04070	COG3107	peptidoglycan biosynthetic process
A4G13_RS04075	COG0792	nuclease activity
A4G13_RS04080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4G13_RS04085	COG2823	Periplasmic or secreted lipoprotein
A4G13_RS04125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4G13_RS04130	COG0151	Belongs to the GarS family
A4G13_RS04135	COG0138	bifunctional purine biosynthesis protein purh
A4G13_RS04140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4G13_RS04155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G13_RS04160	COG1129	ABC transporter
A4G13_RS04160	COG0842	Transport permease protein
A4G13_RS04165	COG0842	Transport permease protein
A4G13_RS04175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4G13_RS04180	COG0024	Methionine aminopeptidase
A4G13_RS04185	COG0316	Belongs to the HesB IscA family
A4G13_RS04195	COG1760	l-serine dehydratase
A4G13_RS04200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G13_RS04205	COG0307	riboflavin synthase, alpha
A4G13_RS04210	COG0534	Mate efflux family protein
A4G13_RS04215	COG4774	siderophore transport
A4G13_RS04220	COG4178	(ABC) transporter
A4G13_RS04230	COG0440	acetolactate synthase activity
A4G13_RS04235	COG0028	Belongs to the TPP enzyme family
A4G13_RS04240	COG1757	Na H antiporter
A4G13_RS04245	COG2916	Histone family protein nucleoid-structuring protein H-NS
A4G13_RS04250	COG0788	formyltetrahydrofolate deformylase activity
A4G13_RS04255	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4G13_RS04260	COG4166	transmembrane transport
A4G13_RS04265	COG3133	Outer membrane lipoprotein
A4G13_RS04275	COG3102	Protein conserved in bacteria
A4G13_RS04280	COG0018	arginyl-trna synthetase
A4G13_RS04295	COG0791	NLP P60 protein
A4G13_RS04300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G13_RS04305	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G13_RS04310	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4G13_RS04325	COG2852	Protein conserved in bacteria
A4G13_RS04330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4G13_RS04335	COG4149	molybdate abc transporter
A4G13_RS04340	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4G13_RS04345	COG2005	Transcriptional regulator
A4G13_RS04350	COG2050	protein possibly involved in aromatic compounds catabolism
A4G13_RS04355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A4G13_RS04385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4G13_RS04390	COG0045	succinate-CoA ligase (ADP-forming) activity
A4G13_RS04395	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G13_RS04400	COG0567	Dehydrogenase, E1 component
A4G13_RS04405	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4G13_RS04410	COG0318	PFAM AMP-dependent synthetase and ligase
A4G13_RS04415	COG3065	identical protein binding
A4G13_RS04420	COG1214	PFAM Peptidase M22, glycoprotease
A4G13_RS04425	COG1199	ATP-dependent helicase activity
A4G13_RS04430	COG0676	glucose-6-phosphate 1-epimerase activity
A4G13_RS04440	COG4608	Belongs to the ABC transporter superfamily
A4G13_RS04445	COG0444	Belongs to the ABC transporter superfamily
A4G13_RS04450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G13_RS04455	COG0601	transmembrane transport
A4G13_RS04460	COG0210	DNA helicase
A4G13_RS04465	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G13_RS04470	COG0556	nucleotide-excision repair
A4G13_RS04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G13_RS04490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4G13_RS04490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4G13_RS04495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4G13_RS04500	COG1881	PFAM PEBP family protein
A4G13_RS04505	COG0471	metal ion transport
A4G13_RS04525	COG0789	Transcriptional regulator
A4G13_RS04535	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A4G13_RS04540	COG0673	inositol 2-dehydrogenase activity
A4G13_RS04560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4G13_RS04575	COG1943	Transposase
A4G13_RS04595	COG1373	ATPase (AAA superfamily
A4G13_RS04620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G13_RS04625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G13_RS04630	COG0583	DNA-binding transcription factor activity
A4G13_RS04640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G13_RS04650	COG2814	Major facilitator Superfamily
A4G13_RS04655	COG0673	inositol 2-dehydrogenase activity
A4G13_RS04670	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4G13_RS04675	COG0667	Aldo Keto reductase
A4G13_RS04685	COG1230	cation diffusion facilitator family transporter
A4G13_RS04695	COG1643	Atp-dependent helicase
A4G13_RS04700	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A4G13_RS04705	COG2707	UPF0756 membrane protein
A4G13_RS04715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4G13_RS04720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4G13_RS04725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4G13_RS04730	COG0195	Participates in both transcription termination and antitermination
A4G13_RS04735	COG0779	Required for maturation of 30S ribosomal subunits
A4G13_RS04745	COG0515	serine threonine protein kinase
A4G13_RS04755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4G13_RS04760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4G13_RS04775	COG1522	sequence-specific DNA binding
A4G13_RS04785	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A4G13_RS04790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4G13_RS04795	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A4G13_RS04805	COG0309	Hydrogenase expression formation protein (HypE)
A4G13_RS04810	COG0409	Hydrogenase expression formation protein
A4G13_RS04815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4G13_RS04820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4G13_RS04825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4G13_RS04830	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A4G13_RS04835	COG3094	Invasion gene expression up-regulator, SirB
A4G13_RS04840	COG0023	Translation Initiation Factor
A4G13_RS04845	COG0284	orotidine-5'-phosphate decarboxylase activity
A4G13_RS04850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A4G13_RS04855	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A4G13_RS04860	COG0776	regulation of translation
A4G13_RS04865	COG0539	negative regulation of cytoplasmic translation
A4G13_RS04870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4G13_RS04880	COG0137	argininosuccinate synthase activity
A4G13_RS04885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G13_RS04890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4G13_RS04900	COG3206	protein involved in exopolysaccharide biosynthesis
A4G13_RS04900	COG0489	protein tyrosine kinase activity
A4G13_RS04905	COG1596	polysaccharide export
A4G13_RS04915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4G13_RS04930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4G13_RS04950	COG0438	transferase activity, transferring glycosyl groups
A4G13_RS04975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A4G13_RS04980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4G13_RS04985	COG0745	RESPONSE REGULATOR receiver
A4G13_RS04990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4G13_RS04995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4G13_RS05000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4G13_RS05005	COG2190	(PTS) system
A4G13_RS05010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G13_RS05015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS05020	COG1162	GTPase activity
A4G13_RS05025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4G13_RS05040	COG0802	atpase or kinase
A4G13_RS05045	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4G13_RS05045	COG1388	LysM domain
A4G13_RS05050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4G13_RS05060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4G13_RS05065	COG1923	regulation of RNA biosynthetic process
A4G13_RS05070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4G13_RS05075	COG0626	cystathionine gamma-synthase activity
A4G13_RS05080	COG0450	alkyl hydroperoxide reductase
A4G13_RS05090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4G13_RS05095	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A4G13_RS05100	COG1178	ABC-type Fe3 transport system permease component
A4G13_RS05105	COG4143	(ABC) transporter
A4G13_RS05110	COG1940	carbohydrate kinase activity
A4G13_RS05115	COG0673	inositol 2-dehydrogenase activity
A4G13_RS05125	COG2211	Major facilitator Superfamily
A4G13_RS05135	COG0671	phosphoesterase, PA-phosphatase related
A4G13_RS05140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4G13_RS05145	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A4G13_RS05150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4G13_RS05155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4G13_RS05160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4G13_RS05165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4G13_RS05170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4G13_RS05175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4G13_RS05185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4G13_RS05190	COG0375	protein maturation
A4G13_RS05195	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A4G13_RS05205	COG0795	lipopolysaccharide-transporting ATPase activity
A4G13_RS05210	COG0795	lipopolysaccharide-transporting ATPase activity
A4G13_RS05215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4G13_RS05225	COG1473	amidohydrolase
A4G13_RS05230	COG3069	C4-dicarboxylate transmembrane transporter activity
A4G13_RS05240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G13_RS05245	COG0525	valine-tRNA ligase activity
A4G13_RS05250	COG2927	DNA polymerase III (CHI subunit)
A4G13_RS05255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4G13_RS05260	COG0343	queuine tRNA-ribosyltransferase activity
A4G13_RS05265	COG3945	hemerythrin HHE cation binding domain
A4G13_RS05275	COG1862	Preprotein translocase
A4G13_RS05280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G13_RS05285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G13_RS05290	COG0741	lytic transglycosylase activity
A4G13_RS05295	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A4G13_RS05300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G13_RS05305	COG4221	oxidoreductase activity
A4G13_RS05310	COG1368	sulfuric ester hydrolase activity
A4G13_RS05325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4G13_RS05330	COG0328	RNA-DNA hybrid ribonuclease activity
A4G13_RS05335	COG2926	Belongs to the UPF0265 family
A4G13_RS05340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4G13_RS05345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4G13_RS05350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4G13_RS05370	COG2814	Major facilitator Superfamily
A4G13_RS05380	COG0717	Belongs to the dCTP deaminase family
A4G13_RS05385	COG0572	uridine kinase
A4G13_RS05390	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G13_RS05395	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G13_RS05405	COG3842	ATPase activity
A4G13_RS05410	COG2813	Specifically methylates the guanine in position
A4G13_RS05415	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A4G13_RS05420	COG0456	acetyltransferase
A4G13_RS05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4G13_RS05430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G13_RS05430	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4G13_RS05440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4G13_RS05445	COG0697	spore germination
A4G13_RS05450	COG0697	spore germination
A4G13_RS05455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4G13_RS05460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4G13_RS05465	COG0142	geranyltranstransferase activity
A4G13_RS05470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4G13_RS05475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4G13_RS05480	COG2860	membrane
A4G13_RS05485	COG2376	Dihydroxyacetone kinase
A4G13_RS05490	COG1461	Dihydroxyacetone kinase
A4G13_RS05495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G13_RS05495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS05495	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A4G13_RS05505	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4G13_RS05515	COG1879	ABC-type sugar transport system periplasmic component
A4G13_RS05520	COG0527	aspartate kinase activity
A4G13_RS05525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4G13_RS05530	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A4G13_RS05545	COG0330	HflC and HflK could
A4G13_RS05550	COG0330	HflC and HflK could
A4G13_RS05555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4G13_RS05560	COG1530	ribonuclease E activity
A4G13_RS05565	COG0564	pseudouridine synthase activity
A4G13_RS05580	COG0626	cystathionine gamma-synthase activity
A4G13_RS05605	COG1408	metallophosphoesterase
A4G13_RS05610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G13_RS05610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G13_RS05615	COG0489	protein tyrosine kinase activity
A4G13_RS05620	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A4G13_RS05625	COG1053	succinate dehydrogenase
A4G13_RS05630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4G13_RS05640	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A4G13_RS05645	COG1605	Chorismate mutase
A4G13_RS05645	COG0077	Prephenate dehydratase
A4G13_RS05655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A4G13_RS05660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4G13_RS05665	COG0849	cell division
A4G13_RS05670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4G13_RS05675	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G13_RS05680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4G13_RS05685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4G13_RS05695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4G13_RS05700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4G13_RS05705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4G13_RS05710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4G13_RS05715	COG0768	penicillin binding
A4G13_RS05720	COG3116	cell division
A4G13_RS05725	COG0275	rRNA processing
A4G13_RS05730	COG2001	Belongs to the MraZ family
A4G13_RS05735	COG1966	Carbon starvation protein
A4G13_RS05745	COG1444	tRNA N-acetyltransferase activity
A4G13_RS05750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4G13_RS05755	COG1702	phosphate starvation-inducible protein PhoH
A4G13_RS05760	COG2918	glutathione biosynthetic process
A4G13_RS05760	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G13_RS05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G13_RS05775	COG0765	amino acid transport
A4G13_RS05780	COG0765	amino acid transport
A4G13_RS05790	COG0583	DNA-binding transcription factor activity
A4G13_RS05795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4G13_RS05810	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4G13_RS05815	COG0494	nUDIX hydrolase
A4G13_RS05825	COG0326	Molecular chaperone. Has ATPase activity
A4G13_RS05830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4G13_RS05835	COG3091	SprT-like family
A4G13_RS05840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4G13_RS05845	COG0083	homoserine kinase activity
A4G13_RS05850	COG0460	homoserine dehydrogenase
A4G13_RS05850	COG0527	aspartate kinase activity
A4G13_RS05865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4G13_RS05870	COG5007	Belongs to the BolA IbaG family
A4G13_RS05875	COG3113	response to antibiotic
A4G13_RS05880	COG2854	intermembrane phospholipid transfer
A4G13_RS05885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4G13_RS05890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4G13_RS05895	COG1127	ABC transporter
A4G13_RS05900	COG3117	lipopolysaccharide transmembrane transporter activity
A4G13_RS05905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A4G13_RS05910	COG1137	ATPase activity
A4G13_RS05915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS05920	COG1660	Displays ATPase and GTPase activities
A4G13_RS05925	COG2975	iron-sulfur cluster assembly
A4G13_RS05930	COG0633	Ferredoxin
A4G13_RS05935	COG0443	Heat shock 70 kDa protein
A4G13_RS05940	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4G13_RS05950	COG0822	iron-sulfur transferase activity
A4G13_RS05960	COG1104	cysteine desulfurase activity
A4G13_RS05965	COG1959	2 iron, 2 sulfur cluster binding
A4G13_RS05970	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A4G13_RS05980	COG2198	Histidine kinase
A4G13_RS05980	COG5002	protein histidine kinase activity
A4G13_RS05980	COG0784	Response regulator, receiver
A4G13_RS06015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4G13_RS06020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G13_RS06025	COG1758	RNA polymerase activity
A4G13_RS06030	COG0194	GDP metabolic process
A4G13_RS06035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4G13_RS06040	COG0823	Involved in the tonB-independent uptake of proteins
A4G13_RS06055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4G13_RS06060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A4G13_RS06065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4G13_RS06070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4G13_RS06075	COG1555	photosystem II stabilization
A4G13_RS06080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4G13_RS06085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4G13_RS06090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4G13_RS06095	COG0196	riboflavin kinase activity
A4G13_RS06100	COG0697	spore germination
A4G13_RS06105	COG0697	spore germination
A4G13_RS06110	COG0728	peptidoglycan biosynthetic process
A4G13_RS06115	COG0268	Binds directly to 16S ribosomal RNA
A4G13_RS06125	COG0560	Phosphoserine phosphatase
A4G13_RS06130	COG1666	GTP binding
A4G13_RS06140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4G13_RS06155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4G13_RS06160	COG1435	thymidine kinase activity
A4G13_RS06170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4G13_RS06175	COG3115	cell septum assembly
A4G13_RS06185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4G13_RS06240	COG4964	Belongs to the GSP D family
A4G13_RS06265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4G13_RS06275	COG4145	pantothenate transmembrane transporter activity
A4G13_RS06280	COG3924	membrane
A4G13_RS06285	COG0439	Biotin carboxylase
A4G13_RS06290	COG0511	ligase activity, forming carbon-carbon bonds
A4G13_RS06295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4G13_RS06315	COG0688	phosphatidylethanolamine metabolic process
A4G13_RS06320	COG0545	Peptidyl-prolyl cis-trans isomerase
A4G13_RS06325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4G13_RS06330	COG2966	Psort location CytoplasmicMembrane, score
A4G13_RS06335	COG3610	response to peptide
A4G13_RS06340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4G13_RS06345	COG0602	queuosine metabolic process
A4G13_RS06350	COG0720	synthase
A4G13_RS06355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4G13_RS06360	COG2321	neutral zinc metallopeptidase
A4G13_RS06375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4G13_RS06380	COG1652	LysM domain
A4G13_RS06385	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4G13_RS06390	COG0740	serine-type endopeptidase activity
A4G13_RS06395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4G13_RS06400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4G13_RS06405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4G13_RS06410	COG1720	tRNA m6t6A37 methyltransferase activity
A4G13_RS06415	COG1575	Belongs to the MenA family. Type 1 subfamily
A4G13_RS06420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4G13_RS06425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4G13_RS06430	COG0513	Belongs to the DEAD box helicase family
A4G13_RS06435	COG0295	cytidine deaminase activity
A4G13_RS06440	COG0799	negative regulation of ribosome biogenesis
A4G13_RS06445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4G13_RS06450	COG0768	penicillin binding
A4G13_RS06455	COG0772	Belongs to the SEDS family
A4G13_RS06460	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4G13_RS06460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4G13_RS06465	COG1686	Belongs to the peptidase S11 family
A4G13_RS06475	COG0321	lipoyl(octanoyl) transferase activity
A4G13_RS06480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4G13_RS06490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4G13_RS06495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A4G13_RS06505	COG0564	pseudouridine synthase activity
A4G13_RS06515	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A4G13_RS06520	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A4G13_RS06525	COG0437	4 iron, 4 sulfur cluster binding
A4G13_RS06530	COG3301	Polysulphide reductase, NrfD
A4G13_RS06535	COG1138	Cytochrome C-type biogenesis protein
A4G13_RS06540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G13_RS06545	COG4235	cytochrome complex assembly
A4G13_RS06545	COG3088	subunit of a heme lyase
A4G13_RS06550	COG4235	cytochrome complex assembly
A4G13_RS06550	COG3088	subunit of a heme lyase
A4G13_RS06555	COG2081	HI0933 family
A4G13_RS06565	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A4G13_RS06570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4G13_RS06570	COG0047	phosphoribosylformylglycinamidine synthase activity
A4G13_RS06590	COG0583	DNA-binding transcription factor activity
A4G13_RS06615	COG1454	alcohol dehydrogenase
A4G13_RS06620	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4G13_RS06625	COG2974	May be involved in recombination
A4G13_RS06635	COG2814	Major facilitator Superfamily
A4G13_RS06640	COG0436	Aminotransferase
A4G13_RS06650	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4G13_RS06655	COG2267	carboxylic ester hydrolase activity
A4G13_RS06675	COG1399	metal-binding, possibly nucleic acid-binding protein
A4G13_RS06685	COG0416	fatty acid biosynthetic process
A4G13_RS06690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G13_RS06695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4G13_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
A4G13_RS06705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4G13_RS06710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4G13_RS06715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4G13_RS06725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4G13_RS06730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4G13_RS06730	COG0140	phosphoribosyl-ATP diphosphatase activity
A4G13_RS06735	COG0107	imidazoleglycerol-phosphate synthase activity
A4G13_RS06740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4G13_RS06745	COG2258	MOSC domain
A4G13_RS06750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4G13_RS06775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4G13_RS06780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4G13_RS06785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4G13_RS06785	COG0131	Imidazoleglycerol-phosphate dehydratase
A4G13_RS06790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4G13_RS06795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4G13_RS06800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4G13_RS06805	COG2226	methyltransferase
A4G13_RS06810	COG0814	amino acid
A4G13_RS06815	COG2364	Membrane
A4G13_RS06820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4G13_RS06825	COG0813	purine-nucleoside phosphorylase activity
A4G13_RS06830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4G13_RS06840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4G13_RS06845	COG1011	Hydrolase
A4G13_RS06855	COG0402	S-adenosylhomocysteine deaminase activity
A4G13_RS06860	COG3083	sulfuric ester hydrolase activity
A4G13_RS06865	COG3082	Protein of unknown function (DUF1414)
A4G13_RS06870	COG3081	Nucleoid-associated protein
A4G13_RS06875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4G13_RS06880	COG0745	RESPONSE REGULATOR receiver
A4G13_RS06885	COG2205	protein histidine kinase activity
A4G13_RS06890	COG0471	metal ion transport
A4G13_RS06895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4G13_RS06900	COG3063	Type IV pilus biogenesis stability protein PilW
A4G13_RS06905	COG1426	Protein conserved in bacteria
A4G13_RS06910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4G13_RS06915	COG0124	histidyl-tRNA synthetase
A4G13_RS06920	COG2976	Protein conserved in bacteria
A4G13_RS06925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G13_RS06930	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A4G13_RS06940	COG0750	zinc metalloprotease
A4G13_RS06945	COG0575	Belongs to the CDS family
A4G13_RS06955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4G13_RS06960	COG0233	cytoplasmic translational termination
A4G13_RS06965	COG0528	UMP kinase activity
A4G13_RS06970	COG2194	sulfuric ester hydrolase activity
A4G13_RS06975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4G13_RS06980	COG0052	Belongs to the universal ribosomal protein uS2 family
A4G13_RS06995	COG1309	transcriptional regulator
A4G13_RS07000	COG0756	dUTP diphosphatase activity
A4G13_RS07005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4G13_RS07015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4G13_RS07020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4G13_RS07025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4G13_RS07030	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A4G13_RS07040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4G13_RS07045	COG0513	Belongs to the DEAD box helicase family
A4G13_RS07050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4G13_RS07055	COG1519	Transferase
A4G13_RS07060	COG0752	glycyl-tRNA synthetase alpha subunit
A4G13_RS07075	COG2852	Protein conserved in bacteria
A4G13_RS07080	COG0751	glycine-tRNA ligase activity
A4G13_RS07095	COG1393	Belongs to the ArsC family
A4G13_RS07100	COG3036	rescue of stalled ribosome
A4G13_RS07110	COG0859	PFAM glycosyl transferase family 9
A4G13_RS07115	COG3642	lipopolysaccharide core region biosynthetic process
A4G13_RS07130	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A4G13_RS07135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4G13_RS07140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4G13_RS07145	COG4796	Type ii and iii secretion system protein
A4G13_RS07160	COG3166	PFAM Fimbrial assembly family protein
A4G13_RS07170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4G13_RS07175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A4G13_RS07180	COG2610	gluconate transmembrane transporter activity
A4G13_RS07185	COG3622	Belongs to the hyi family
A4G13_RS07190	COG0235	Class ii aldolase
A4G13_RS07195	COG3395	kinase activity
A4G13_RS07200	COG2084	Dehydrogenase
A4G13_RS07205	COG1349	DNA-binding transcription factor activity
A4G13_RS07210	COG1027	Aspartate ammonia-lyase
A4G13_RS07215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G13_RS07220	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4G13_RS07225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4G13_RS07230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4G13_RS07235	COG2271	Major facilitator Superfamily
A4G13_RS07240	COG0584	glycerophosphoryl diester phosphodiesterase
A4G13_RS07245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4G13_RS07250	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A4G13_RS07255	COG0247	lactate metabolic process
A4G13_RS07260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4G13_RS07265	COG0606	chelatase, subunit chli
A4G13_RS07275	COG1289	transmembrane transporter activity
A4G13_RS07280	COG0203	ribosomal protein L17
A4G13_RS07285	COG0202	RNA polymerase activity
A4G13_RS07290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4G13_RS07295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4G13_RS07300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4G13_RS07305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4G13_RS07310	COG0201	protein transport
A4G13_RS07315	COG0200	Binds to the 23S rRNA
A4G13_RS07325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4G13_RS07330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4G13_RS07335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4G13_RS07340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4G13_RS07345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4G13_RS07350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4G13_RS07355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4G13_RS07365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4G13_RS07370	COG0255	Belongs to the universal ribosomal protein uL29 family
A4G13_RS07375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4G13_RS07380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4G13_RS07385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4G13_RS07390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4G13_RS07395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4G13_RS07400	COG0089	rRNA binding
A4G13_RS07405	COG0088	Forms part of the polypeptide exit tunnel
A4G13_RS07410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4G13_RS07415	COG0051	transcription antitermination factor activity, RNA binding
A4G13_RS07420	COG0252	asparaginase activity
A4G13_RS07425	COG0038	chloride channel
A4G13_RS07430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4G13_RS07435	COG0747	negative chemotaxis
A4G13_RS07440	COG2814	Major facilitator Superfamily
A4G13_RS07445	COG1763	Mo-molybdopterin cofactor biosynthetic process
A4G13_RS07450	COG0746	molybdenum cofactor guanylyltransferase activity
A4G13_RS07455	COG3084	Protein conserved in bacteria
A4G13_RS07460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4G13_RS07465	COG3085	chromosome segregation
A4G13_RS07475	COG0442	prolyl-tRNA aminoacylation
A4G13_RS07480	COG0259	pyridoxamine-phosphate oxidase activity
A4G13_RS07490	COG4580	involved in the transport of maltose and maltodextrins
A4G13_RS07495	COG3842	ATPase activity
A4G13_RS07505	COG1175	transmembrane transport
A4G13_RS07510	COG3833	ABC-type maltose transport systems, permease component
A4G13_RS07515	COG0366	Alpha amylase catalytic
A4G13_RS07520	COG2909	trisaccharide binding
A4G13_RS07525	COG0058	SHG alpha-glucan phosphorylase activity
A4G13_RS07530	COG1640	4-alpha-glucanotransferase
A4G13_RS07535	COG4989	oxidoreductase activity
A4G13_RS07540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4G13_RS07550	COG1965	Belongs to the frataxin family
A4G13_RS07560	COG0019	diaminopimelate decarboxylase activity
A4G13_RS07565	COG0625	glutathione transferase activity
A4G13_RS07580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G13_RS07600	COG2259	Doxx family
A4G13_RS07605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4G13_RS07605	COG0475	glutathione-regulated potassium exporter activity
A4G13_RS07610	COG1741	Belongs to the pirin family
A4G13_RS07620	COG1012	belongs to the aldehyde dehydrogenase family
A4G13_RS07625	COG2207	Transcriptional regulator
A4G13_RS07625	COG1917	Cupin 2, conserved barrel domain protein
A4G13_RS07630	COG0583	DNA-binding transcription factor activity
A4G13_RS07640	COG0110	maltose O-acetyltransferase activity
A4G13_RS07675	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4G13_RS07680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A4G13_RS07695	COG0778	Nitroreductase
A4G13_RS07715	COG1373	ATPase (AAA superfamily
A4G13_RS07730	COG0653	protein targeting
A4G13_RS07745	COG2207	Transcriptional regulator
A4G13_RS07765	COG1764	response to oxidative stress
A4G13_RS07775	COG1902	pentaerythritol trinitrate reductase activity
A4G13_RS07790	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4G13_RS07795	COG0667	Aldo Keto reductase
A4G13_RS07800	COG0583	DNA-binding transcription factor activity
A4G13_RS07820	COG0583	DNA-binding transcription factor activity
A4G13_RS07830	COG0778	Nitroreductase
A4G13_RS07835	COG0583	DNA-binding transcription factor activity
A4G13_RS07840	COG0583	DNA-binding transcription factor activity
A4G13_RS07845	COG1902	pentaerythritol trinitrate reductase activity
A4G13_RS07895	COG4221	oxidoreductase activity
A4G13_RS07915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G13_RS07915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G13_RS07915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4G13_RS07920	COG1105	Belongs to the carbohydrate kinase PfkB family
A4G13_RS07925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS07925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS07935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G13_RS07945	COG0705	Rhomboid family
A4G13_RS07950	COG1349	DNA-binding transcription factor activity
A4G13_RS07955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4G13_RS07980	COG1072	(Pantothenic acid kinase))
A4G13_RS07985	COG0251	oxidation-reduction process
A4G13_RS07990	COG1454	alcohol dehydrogenase
A4G13_RS07990	COG1012	belongs to the aldehyde dehydrogenase family
A4G13_RS08000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G13_RS08010	COG0512	Glutamine amidotransferase of anthranilate synthase
A4G13_RS08015	COG0569	domain protein
A4G13_RS08020	COG1970	mechanosensitive ion channel activity
A4G13_RS08025	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A4G13_RS08040	COG0242	peptide deformylase activity
A4G13_RS08045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4G13_RS08050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4G13_RS08050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4G13_RS08055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4G13_RS08060	COG0363	glucosamine-6-phosphate deaminase activity
A4G13_RS08065	COG2731	YhcH YjgK YiaL family protein
A4G13_RS08070	COG2183	response to ionizing radiation
A4G13_RS08100	COG1045	serine acetyltransferase
A4G13_RS08105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4G13_RS08110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A4G13_RS08115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G13_RS08120	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4G13_RS08130	COG0129	dihydroxy-acid dehydratase activity
A4G13_RS08135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4G13_RS08140	COG0028	Belongs to the TPP enzyme family
A4G13_RS08150	COG0561	phosphatase activity
A4G13_RS08155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4G13_RS08160	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A4G13_RS08165	COG1595	DNA-templated transcription, initiation
A4G13_RS08170	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A4G13_RS08175	COG3026	antisigma factor binding
A4G13_RS08180	COG3086	response to oxidative stress
A4G13_RS08185	COG0316	Belongs to the HesB IscA family
A4G13_RS08185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A4G13_RS08190	COG1040	competence protein
A4G13_RS08195	COG0561	phosphatase activity
A4G13_RS08210	COG2853	Lipoprotein
A4G13_RS08215	COG3013	Belongs to the UPF0304 family
A4G13_RS08225	COG2137	regulation of response to DNA damage stimulus
A4G13_RS08230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4G13_RS08235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4G13_RS08245	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
A4G13_RS08250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4G13_RS08255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G13_RS08260	COG0187	DNA topoisomerase II activity
A4G13_RS08275	COG3074	FtsZ-dependent cytokinesis
A4G13_RS08280	COG1494	fructose-1,6-bisphosphatase
A4G13_RS08290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G13_RS08295	COG0859	PFAM glycosyl transferase family 9
A4G13_RS08305	COG0859	PFAM glycosyl transferase family 9
A4G13_RS08310	COG3691	Protein conserved in bacteria
A4G13_RS08315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4G13_RS08320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4G13_RS08325	COG1022	Amp-dependent synthetase and ligase
A4G13_RS08330	COG1388	LysM domain
A4G13_RS08330	COG4942	peptidase
A4G13_RS08340	COG1238	metal cluster binding
A4G13_RS08345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A4G13_RS08350	COG0585	pseudouridine synthase activity
A4G13_RS08355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4G13_RS08360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4G13_RS08365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A4G13_RS08370	COG3005	denitrification pathway
A4G13_RS08375	COG3043	anaerobic respiration
A4G13_RS08380	COG0348	domain, Protein
A4G13_RS08385	COG0437	4 iron, 4 sulfur cluster binding
A4G13_RS08390	COG0243	molybdopterin cofactor binding
A4G13_RS08395	COG3062	negative regulation of establishment of protein localization
A4G13_RS08400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4G13_RS08405	COG2271	Major facilitator Superfamily
A4G13_RS08410	COG2197	response regulator
A4G13_RS08415	COG3851	Histidine kinase
A4G13_RS08420	COG2271	Major facilitator Superfamily
A4G13_RS08425	COG3850	Histidine kinase
A4G13_RS08435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G13_RS08440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4G13_RS08445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A4G13_RS08455	COG1902	pentaerythritol trinitrate reductase activity
A4G13_RS08460	COG3070	regulator of competence-specific genes
A4G13_RS08495	COG0733	neurotransmitter:sodium symporter activity
A4G13_RS08505	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS08505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G13_RS08510	COG3715	PTS system
A4G13_RS08515	COG3716	PTS system mannose fructose sorbose family IID component
A4G13_RS08525	COG1609	Transcriptional regulator
A4G13_RS08525	COG2207	Transcriptional regulator
A4G13_RS08530	COG4214	carbohydrate transport
A4G13_RS08535	COG1129	ABC transporter
A4G13_RS08540	COG4213	ABC transporter substrate-binding protein
A4G13_RS08545	COG2115	Belongs to the xylose isomerase family
A4G13_RS08550	COG1070	Carbohydrate kinase
A4G13_RS08555	COG0372	Belongs to the citrate synthase family
A4G13_RS08560	COG0538	isocitrate dehydrogenase activity
A4G13_RS08570	COG0742	ribosomal rna small subunit methyltransferase
A4G13_RS08575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4G13_RS08580	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A4G13_RS08585	COG0437	4 iron, 4 sulfur cluster binding
A4G13_RS08590	COG5557	Pfam Polysulphide reductase, NrfD
A4G13_RS08595	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A4G13_RS08600	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4G13_RS08605	COG1773	rubredoxin
A4G13_RS08610	COG0298	carbon dioxide binding
A4G13_RS08615	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4G13_RS08620	COG2818	Glycosylase
A4G13_RS08625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4G13_RS08630	COG0445	tRNA wobble uridine modification
A4G13_RS08635	COG0357	Ribosomal RNA small subunit methyltransferase G
A4G13_RS08645	COG0356	it plays a direct role in the translocation of protons across the membrane
A4G13_RS08655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4G13_RS08660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4G13_RS08665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4G13_RS08670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4G13_RS08675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4G13_RS08680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4G13_RS08685	COG0561	phosphatase activity
A4G13_RS08695	COG1187	pseudouridine synthase activity
A4G13_RS08705	COG3477	response to acidic pH
A4G13_RS08710	COG3276	selenocysteine insertion sequence binding
A4G13_RS08715	COG1921	L-seryl-tRNASec selenium transferase activity
A4G13_RS08725	COG0243	molybdopterin cofactor binding
A4G13_RS08730	COG0437	4 iron, 4 sulfur cluster binding
A4G13_RS08735	COG3302	dmso reductase anchor subunit
A4G13_RS08740	COG3381	protein complex oligomerization
A4G13_RS08745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4G13_RS08745	COG2221	Nitrite and sulphite reductase 4Fe-4S
A4G13_RS08750	COG0668	transmembrane transport
A4G13_RS08760	COG0546	phosphoglycolate phosphatase activity
A4G13_RS08765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4G13_RS08770	COG1070	Carbohydrate kinase
A4G13_RS08775	COG4806	L-rhamnose isomerase
A4G13_RS08780	COG0235	Class ii aldolase
A4G13_RS08790	COG1454	alcohol dehydrogenase
A4G13_RS08795	COG3254	rhamnose metabolic process
A4G13_RS08800	COG4977	sequence-specific DNA binding
A4G13_RS08805	COG4977	sequence-specific DNA binding
A4G13_RS08810	COG4977	sequence-specific DNA binding
A4G13_RS08815	COG0588	phosphoglycerate mutase activity
A4G13_RS08820	COG4942	peptidase
A4G13_RS08825	COG2861	carbohydrate metabolic process
A4G13_RS08830	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4G13_RS08835	COG5413	integral membrane protein
A4G13_RS08840	COG1349	DNA-binding transcription factor activity
A4G13_RS08845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4G13_RS08855	COG0617	tRNA 3'-terminal CCA addition
A4G13_RS08860	COG4991	sh3 domain protein
A4G13_RS08865	COG0306	phosphate transporter
A4G13_RS08870	COG1392	Phosphate transport regulator
A4G13_RS08875	COG3025	triphosphatase activity
A4G13_RS08880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4G13_RS08915	COG1285	pathogenesis
A4G13_RS08920	COG2267	carboxylic ester hydrolase activity
A4G13_RS08925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4G13_RS08930	COG2177	Part of the ABC transporter FtsEX involved in
A4G13_RS08935	COG2884	Cell division ATP-binding protein ftsE
A4G13_RS08945	COG0431	NADPH-dependent FMN reductase
A4G13_RS08955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4G13_RS08960	COG1794	racemase activity, acting on amino acids and derivatives
A4G13_RS08965	COG0363	glucosamine-6-phosphate deaminase activity
A4G13_RS08970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4G13_RS08975	COG1218	3'(2'),5'-bisphosphate nucleotidase
A4G13_RS08985	COG0494	nUDIX hydrolase
A4G13_RS08990	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A4G13_RS08995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS09015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4G13_RS09020	COG1275	C4-dicarboxylate transporter malic acid transport protein
A4G13_RS09030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4G13_RS09035	COG0786	glutamate:sodium symporter activity
A4G13_RS09040	COG1490	D-aminoacyl-tRNA deacylase activity
A4G13_RS09045	COG1295	ribonuclease BN
A4G13_RS09050	COG3012	SEC-C Motif Domain Protein
A4G13_RS09055	COG0433	COG0433 Predicted ATPase
A4G13_RS09060	COG1522	sequence-specific DNA binding
A4G13_RS09065	COG2502	aspartate--ammonia ligase
A4G13_RS09080	COG3630	sodium ion export across plasma membrane
A4G13_RS09085	COG0758	DNA mediated transformation
A4G13_RS09090	COG0583	DNA-binding transcription factor activity
A4G13_RS09095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4G13_RS09100	COG0235	Class ii aldolase
A4G13_RS09105	COG3623	hexulose-6-phosphate isomerase
A4G13_RS09115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G13_RS09120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G13_RS09125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4G13_RS09130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4G13_RS09135	COG2731	YhcH YjgK YiaL family protein
A4G13_RS09140	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4G13_RS09145	COG1414	Transcriptional regulator
A4G13_RS09150	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A4G13_RS09155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4G13_RS09160	COG2160	L-arabinose isomerase activity
A4G13_RS09175	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4G13_RS09180	COG1129	ABC transporter
A4G13_RS09185	COG1879	ABC-type sugar transport system periplasmic component
A4G13_RS09190	COG0737	Belongs to the 5'-nucleotidase family
A4G13_RS09200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4G13_RS09205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G13_RS09210	COG1454	alcohol dehydrogenase
A4G13_RS09225	COG2731	YhcH YjgK YiaL family protein
A4G13_RS09240	COG1349	DNA-binding transcription factor activity
A4G13_RS09250	COG0551	DNA topoisomerase type I activity
A4G13_RS09255	COG0009	L-threonylcarbamoyladenylate synthase
A4G13_RS09260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4G13_RS09285	COG2095	MarC family integral membrane protein
A4G13_RS09290	COG0742	ribosomal rna small subunit methyltransferase
A4G13_RS09295	COG0552	protein localization to endoplasmic reticulum
A4G13_RS09300	COG3384	dioxygenase
A4G13_RS09305	COG0702	epimerase
A4G13_RS09310	COG1733	regulation of RNA biosynthetic process
A4G13_RS09325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G13_RS09330	COG1609	Transcriptional regulator
A4G13_RS09335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G13_RS09350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4G13_RS09355	COG1309	transcriptional regulator
A4G13_RS09360	COG0583	DNA-binding transcription factor activity
A4G13_RS09365	COG0678	peroxiredoxin activity
A4G13_RS09365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4G13_RS09370	COG2900	Belongs to the SlyX family
A4G13_RS09375	COG0545	Peptidyl-prolyl cis-trans isomerase
A4G13_RS09380	COG2964	Protein conserved in bacteria
A4G13_RS09385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4G13_RS09390	COG2923	Belongs to the DsrF TusC family
A4G13_RS09395	COG2168	tRNA wobble position uridine thiolation
A4G13_RS09400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4G13_RS09405	COG0049	tRNA binding
A4G13_RS09410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4G13_RS09415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4G13_RS09420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4G13_RS09425	COG2129	metallophosphoesterase
A4G13_RS09430	COG3172	ATPase kinase involved in NAD metabolism
A4G13_RS09435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4G13_RS09440	COG0425	Belongs to the sulfur carrier protein TusA family
A4G13_RS09445	COG1739	Uncharacterized protein family UPF0029
A4G13_RS09450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4G13_RS09455	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A4G13_RS09480	COG0789	Transcriptional regulator
A4G13_RS09490	COG1252	NADH dehydrogenase
A4G13_RS09495	COG2816	NAD+ diphosphatase activity
A4G13_RS09500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4G13_RS09505	COG3068	Protein conserved in bacteria
A4G13_RS09510	COG0776	regulation of translation
A4G13_RS09515	COG1349	DNA-binding transcription factor activity
A4G13_RS09520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4G13_RS09525	COG2814	Major facilitator Superfamily
A4G13_RS09530	COG1971	Probably functions as a manganese efflux pump
A4G13_RS09545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4G13_RS09550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G13_RS09555	COG1737	Transcriptional regulator
A4G13_RS09560	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4G13_RS09565	COG1129	ABC transporter
A4G13_RS09580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4G13_RS09585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4G13_RS09595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4G13_RS09600	COG0081	regulation of translation
A4G13_RS09605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4G13_RS09610	COG0222	ribosome binding
A4G13_RS09615	COG0085	RNA polymerase activity
A4G13_RS09620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4G13_RS09625	COG3012	SEC-C Motif Domain Protein
A4G13_RS09625	COG3318	Belongs to the UPF0149 family
A4G13_RS09630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4G13_RS09640	COG1126	abc transporter atp-binding protein
A4G13_RS09645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G13_RS09650	COG4215	(ABC) transporter
A4G13_RS09655	COG4160	amino acid transport
A4G13_RS09660	COG1858	cytochrome C peroxidase
A4G13_RS09665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G13_RS09665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G13_RS09670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4G13_RS09675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4G13_RS09685	COG3078	GTPase activator activity
A4G13_RS09690	COG0564	pseudouridine synthase activity
A4G13_RS09705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4G13_RS09710	COG0165	Argininosuccinate lyase
A4G13_RS09715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4G13_RS09720	COG1381	Involved in DNA repair and RecF pathway recombination
A4G13_RS09725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4G13_RS09730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G13_RS09735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4G13_RS09740	COG3307	-O-antigen
A4G13_RS09745	COG0191	fructose-bisphosphate aldolase activity
A4G13_RS09750	COG0126	phosphoglycerate kinase activity
A4G13_RS09755	COG3719	Belongs to the RNase T2 family
A4G13_RS09760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4G13_RS09765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G13_RS09770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4G13_RS09775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4G13_RS09780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A4G13_RS09785	COG1561	YicC-like family, N-terminal region
A4G13_RS09790	COG0354	folic acid binding
A4G13_RS09795	COG0504	CTP synthase activity
A4G13_RS09800	COG0148	phosphopyruvate hydratase activity
A4G13_RS09815	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
A4G13_RS09820	COG1678	Uncharacterized ACR, COG1678
A4G13_RS09825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4G13_RS09830	COG0174	glutamine synthetase
A4G13_RS09840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4G13_RS09850	COG2153	protein acetylation
A4G13_RS09855	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A4G13_RS09865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A4G13_RS09870	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A4G13_RS09875	COG3071	HemY protein
A4G13_RS09880	COG2959	enzyme of heme biosynthesis
A4G13_RS09890	COG0181	hydroxymethylbilane synthase activity
A4G13_RS09900	COG2197	response regulator
A4G13_RS09905	COG1869	D-ribose catabolic process
A4G13_RS09915	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4G13_RS09920	COG1879	ABC-type sugar transport system periplasmic component
A4G13_RS09925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G13_RS09935	COG0729	surface antigen
A4G13_RS09940	COG2911	Protein conserved in bacteria
A4G13_RS09945	COG0248	Ppx GppA phosphatase
A4G13_RS09955	COG4178	(ABC) transporter
A4G13_RS09960	COG1151	hydroxylamine reductase activity
A4G13_RS09965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4G13_RS09985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4G13_RS09995	COG0456	acetyltransferase
A4G13_RS10000	COG0482	sulfurtransferase activity
A4G13_RS10005	COG2991	Protein conserved in bacteria
A4G13_RS10010	COG1477	protein flavinylation
A4G13_RS10015	COG2871	sodium ion transport
A4G13_RS10020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4G13_RS10025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4G13_RS10030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4G13_RS10040	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4G13_RS10045	COG0271	Belongs to the BolA IbaG family
A4G13_RS10050	COG3056	Lipoprotein
A4G13_RS10070	COG0741	lytic transglycosylase activity
A4G13_RS10075	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A4G13_RS10080	COG1194	a g-specific adenine glycosylase
A4G13_RS10085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4G13_RS10090	COG3171	Protein conserved in bacteria
A4G13_RS10095	COG0598	Magnesium transport protein CorA
A4G13_RS10100	COG0762	integral membrane protein
A4G13_RS10105	COG1872	DUF167
A4G13_RS10110	COG0456	acetyltransferase
A4G13_RS10120	COG4701	Protein of unknown function (DUF721)
A4G13_RS10130	COG0653	protein targeting
A4G13_RS10135	COG0494	nUDIX hydrolase
A4G13_RS10150	COG2358	TRAP transporter, solute receptor (TAXI family
A4G13_RS10155	COG1466	dna polymerase III delta subunit
A4G13_RS10160	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A4G13_RS10165	COG0495	leucyl-tRNA aminoacylation
A4G13_RS10195	COG2608	mercury ion transmembrane transporter activity
A4G13_RS10205	COG1305	Transglutaminase-like
A4G13_RS10215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4G13_RS10225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A4G13_RS10230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4G13_RS10235	COG0589	response to stress
A4G13_RS10240	COG3956	TIGRFAM MazG family protein
A4G13_RS10245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4G13_RS10250	COG1115	amino acid carrier protein
A4G13_RS10260	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A4G13_RS10265	COG0237	dephospho-CoA kinase activity
A4G13_RS10270	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4G13_RS10275	COG1459	type II secretion system
A4G13_RS10280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4G13_RS10285	COG4969	Belongs to the N-Me-Phe pilin family
A4G13_RS10290	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4G13_RS10305	COG0571	ribonuclease III activity
A4G13_RS10315	COG0681	Belongs to the peptidase S26 family
A4G13_RS10320	COG0481	GTPase activity
A4G13_RS10325	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A4G13_RS10330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4G13_RS10335	COG3022	response to hydroperoxide
A4G13_RS10345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4G13_RS10350	COG0205	6-phosphofructokinase activity
A4G13_RS10365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4G13_RS10370	COG3395	kinase activity
A4G13_RS10375	COG0698	ribose 5-phosphate isomerase
A4G13_RS10395	COG2194	sulfuric ester hydrolase activity
A4G13_RS10405	COG0280	phosphate acetyltransferase
A4G13_RS10405	COG0281	malic enzyme
A4G13_RS10415	COG2814	Major facilitator Superfamily
A4G13_RS10425	COG1132	(ABC) transporter
A4G13_RS10435	COG1472	Belongs to the glycosyl hydrolase 3 family
A4G13_RS10440	COG5633	Lipoprotein
A4G13_RS10445	COG0537	adenosine 5'-monophosphoramidase activity
A4G13_RS10450	COG2116	formate transmembrane transporter activity
A4G13_RS10455	COG1882	Formate acetyltransferase
A4G13_RS10460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4G13_RS10465	COG0590	tRNA wobble adenosine to inosine editing
A4G13_RS10470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A4G13_RS10475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4G13_RS10480	COG0730	response to heat
A4G13_RS10485	COG0494	nUDIX hydrolase
A4G13_RS10490	COG3722	fumarate hydratase activity
A4G13_RS10495	COG0246	Mannitol dehydrogenase