locus-tag	class	description
EP01_RS00050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP01_RS00070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP01_RS00075	COG0203	ribosomal protein L17
EP01_RS00080	COG0202	RNA polymerase activity
EP01_RS00085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EP01_RS00090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EP01_RS00095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EP01_RS00100	COG0563	adenylate kinase activity
EP01_RS00105	COG0201	protein transport
EP01_RS00110	COG0200	Binds to the 23S rRNA
EP01_RS00115	COG1841	ribosomal large subunit assembly
EP01_RS00120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EP01_RS00125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EP01_RS00130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EP01_RS00135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EP01_RS00140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EP01_RS00145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EP01_RS00150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EP01_RS00155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EP01_RS00160	COG0255	Belongs to the universal ribosomal protein uL29 family
EP01_RS00165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EP01_RS00170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EP01_RS00175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EP01_RS00180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EP01_RS00185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EP01_RS00190	COG0089	rRNA binding
EP01_RS00195	COG0088	Forms part of the polypeptide exit tunnel
EP01_RS00200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EP01_RS00205	COG0051	transcription antitermination factor activity, RNA binding
EP01_RS00210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP01_RS00215	COG0049	tRNA binding
EP01_RS00220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP01_RS00225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EP01_RS00230	COG0085	RNA polymerase activity
EP01_RS00240	COG0222	ribosome binding
EP01_RS00245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP01_RS00250	COG0081	regulation of translation
EP01_RS00255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP01_RS00260	COG0250	Participates in transcription elongation, termination and antitermination
EP01_RS00275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EP01_RS00305	COG0284	orotidine-5'-phosphate decarboxylase activity
EP01_RS00330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EP01_RS00335	COG0138	bifunctional purine biosynthesis protein purh
EP01_RS00340	COG0047	phosphoribosylformylglycinamidine synthase activity
EP01_RS00345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP01_RS00350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EP01_RS00355	COG0151	Belongs to the GarS family
EP01_RS00365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EP01_RS00490	COG0442	prolyl-tRNA aminoacylation
EP01_RS00495	COG2204	response regulator
EP01_RS00500	COG5000	phosphorelay sensor kinase activity
EP01_RS00505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EP01_RS00510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EP01_RS00510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EP01_RS00515	COG0307	riboflavin synthase, alpha
EP01_RS00545	COG1803	Methylglyoxal synthase
EP01_RS00550	COG0542	response to heat
EP01_RS00560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP01_RS00580	COG0745	RESPONSE REGULATOR receiver
EP01_RS00585	COG1846	Transcriptional regulator
EP01_RS00625	COG1381	Involved in DNA repair and RecF pathway recombination
EP01_RS00685	COG0583	DNA-binding transcription factor activity
EP01_RS00690	COG0861	Integral membrane protein TerC family
EP01_RS00695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EP01_RS00705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP01_RS00710	COG1034	ATP synthesis coupled electron transport
EP01_RS00720	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EP01_RS00725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP01_RS00725	COG0649	NAD binding
EP01_RS00730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP01_RS00755	COG0840	transmembrane signaling receptor activity
EP01_RS00790	COG1132	(ABC) transporter
EP01_RS00795	COG1132	(ABC) transporter
EP01_RS00820	COG3639	organic phosphonate transmembrane transporter activity
EP01_RS00825	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EP01_RS00830	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EP01_RS00845	COG1643	Atp-dependent helicase
EP01_RS00860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EP01_RS00870	COG1045	serine acetyltransferase
EP01_RS00875	COG3481	metal-dependent phosphohydrolase, HD sub domain
EP01_RS00890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP01_RS00895	COG1127	ABC transporter
EP01_RS00900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP01_RS00905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EP01_RS00915	COG3852	Histidine kinase
EP01_RS00935	COG0300	oxidoreductase activity
EP01_RS00940	COG0328	RNA-DNA hybrid ribonuclease activity
EP01_RS00980	COG1074	ATP-dependent DNA helicase activity
EP01_RS01020	COG0237	dephospho-CoA kinase activity
EP01_RS01025	COG0515	serine threonine protein kinase
EP01_RS01030	COG1022	Amp-dependent synthetase and ligase
EP01_RS01050	COG3848	Pyruvate phosphate dikinase
EP01_RS01050	COG0574	Belongs to the PEP-utilizing enzyme family
EP01_RS01100	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP01_RS01105	COG0577	efflux transmembrane transporter activity
EP01_RS01105	COG1136	(ABC) transporter
EP01_RS01130	COG0339	signal peptide processing
EP01_RS01135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EP01_RS01140	COG0497	DNA recombination
EP01_RS01160	COG0840	transmembrane signaling receptor activity
EP01_RS01195	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EP01_RS01210	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP01_RS01215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP01_RS01225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EP01_RS01230	COG0840	transmembrane signaling receptor activity
EP01_RS01240	COG0840	transmembrane signaling receptor activity
EP01_RS01255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP01_RS01260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EP01_RS01265	COG0772	Belongs to the SEDS family
EP01_RS01275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EP01_RS01280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EP01_RS01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EP01_RS01295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EP01_RS01320	COG0514	ATP-dependent DNA helicase (RecQ)
EP01_RS01330	COG0768	penicillin binding
EP01_RS01340	COG0275	rRNA processing
EP01_RS01350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EP01_RS01370	COG2119	membrane
EP01_RS01390	COG1741	Belongs to the pirin family
EP01_RS01395	COG0583	DNA-binding transcription factor activity
EP01_RS01400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EP01_RS01415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EP01_RS01455	COG0741	lytic transglycosylase activity
EP01_RS01455	COG1196	nuclear chromosome segregation
EP01_RS01455	COG0739	heme binding
EP01_RS01460	COG2027	D-alanyl-D-alanine carboxypeptidase
EP01_RS01465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EP01_RS01480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP01_RS01490	COG2176	DNA-directed DNA polymerase activity
EP01_RS01500	COG1360	Flagellar Motor Protein
EP01_RS01505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP01_RS01515	COG0840	transmembrane signaling receptor activity
EP01_RS01545	COG1187	pseudouridine synthase activity
EP01_RS01575	COG2264	protein methyltransferase activity
EP01_RS01580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP01_RS01590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EP01_RS01590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP01_RS01610	COG0726	polysaccharide deacetylase
EP01_RS01645	COG0443	Heat shock 70 kDa protein
EP01_RS01655	COG3384	dioxygenase
EP01_RS01660	COG0400	carboxylic ester hydrolase activity
EP01_RS01665	COG2814	Major facilitator Superfamily
EP01_RS01690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EP01_RS01735	COG2204	response regulator
EP01_RS01740	COG4964	Belongs to the GSP D family
EP01_RS01765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EP01_RS01775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP01_RS01790	COG1191	sigma factor activity
EP01_RS01800	COG1419	protein localization to endoplasmic reticulum
EP01_RS01805	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP01_RS01810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP01_RS01815	COG1684	flagellar biosynthetic protein fliR
EP01_RS01820	COG1987	bacterial-type flagellum assembly
EP01_RS01825	COG1338	Plays a role in the flagellum-specific transport system
EP01_RS01850	COG3237	CsbD-like
EP01_RS01870	COG0483	inositol monophosphate 1-phosphatase activity
EP01_RS01890	COG0210	DNA helicase
EP01_RS01900	COG0840	transmembrane signaling receptor activity
EP01_RS01905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP01_RS01910	COG1509	lysine 2,3-aminomutase activity
EP01_RS01940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP01_RS01975	COG5002	protein histidine kinase activity
EP01_RS01995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EP01_RS02000	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EP01_RS02005	COG4191	Histidine kinase
EP01_RS02025	COG0803	Belongs to the bacterial solute-binding protein 9 family
EP01_RS02030	COG1121	(ABC) transporter
EP01_RS02065	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EP01_RS02075	COG0205	6-phosphofructokinase activity
EP01_RS02085	COG0559	Belongs to the binding-protein-dependent transport system permease family
EP01_RS02125	COG0745	RESPONSE REGULATOR receiver
EP01_RS02140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EP01_RS02160	COG1157	protein secretion by the type III secretion system
EP01_RS02170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EP01_RS02175	COG1766	The M ring may be actively involved in energy transduction
EP01_RS02180	COG1677	Flagellar hook-basal body complex protein FliE
EP01_RS02190	COG1815	bacterial-type flagellum-dependent cell motility
EP01_RS02195	COG2204	response regulator
EP01_RS02210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP01_RS02215	COG1127	ABC transporter
EP01_RS02250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EP01_RS02255	COG1435	thymidine kinase activity
EP01_RS02260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EP01_RS02275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP01_RS02280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EP01_RS02285	COG2866	Carboxypeptidase
EP01_RS02295	COG4191	Histidine kinase
EP01_RS02295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP01_RS02300	COG2205	protein histidine kinase activity
EP01_RS02300	COG0784	Response regulator, receiver
EP01_RS02305	COG0745	RESPONSE REGULATOR receiver
EP01_RS02310	COG2204	response regulator
EP01_RS02365	COG0113	porphobilinogen synthase activity
EP01_RS02375	COG0181	hydroxymethylbilane synthase activity
EP01_RS02380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EP01_RS02390	COG0745	RESPONSE REGULATOR receiver
EP01_RS02395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EP01_RS02400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP01_RS02410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EP01_RS02415	COG1346	cytolysis
EP01_RS02420	COG1380	Effector of murein hydrolase LrgA
EP01_RS02435	COG0513	Belongs to the DEAD box helicase family
EP01_RS02440	COG2945	thiolester hydrolase activity
EP01_RS02440	COG0596	Alpha beta hydrolase
EP01_RS02445	COG0617	tRNA 3'-terminal CCA addition
EP01_RS02455	COG1505	serine-type exopeptidase activity
EP01_RS02460	COG2201	protein-glutamate methylesterase activity
EP01_RS02465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP01_RS02470	COG2198	Histidine kinase
EP01_RS02470	COG0643	Histidine kinase
EP01_RS02475	COG0835	chemotaxis
EP01_RS02500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP01_RS02510	COG0405	Gamma-glutamyltransferase
EP01_RS02530	COG0596	Alpha beta hydrolase
EP01_RS02535	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EP01_RS02545	COG1605	Chorismate mutase
EP01_RS02545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EP01_RS02550	COG2226	methyltransferase
EP01_RS02555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP01_RS02570	COG2204	response regulator
EP01_RS02585	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EP01_RS02590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EP01_RS02595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP01_RS02615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EP01_RS02625	COG0667	Aldo Keto reductase
EP01_RS02670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EP01_RS02680	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EP01_RS02690	COG1335	isochorismatase
EP01_RS02695	COG1741	Belongs to the pirin family
EP01_RS02710	COG1741	Belongs to the pirin family
EP01_RS02720	COG1956	GAF domain-containing protein
EP01_RS02740	COG1309	transcriptional regulator
EP01_RS02755	COG0708	Exodeoxyribonuclease III
EP01_RS02760	COG0450	alkyl hydroperoxide reductase
EP01_RS02770	COG0745	RESPONSE REGULATOR receiver
EP01_RS02775	COG2205	protein histidine kinase activity
EP01_RS02775	COG2198	Histidine kinase
EP01_RS02775	COG0784	Response regulator, receiver
EP01_RS02805	COG0793	Belongs to the peptidase S41A family
EP01_RS02810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP01_RS02815	COG3186	Phenylalanine-4-hydroxylase
EP01_RS02860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP01_RS02875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP01_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
EP01_RS02920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EP01_RS02925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EP01_RS02935	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EP01_RS02940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EP01_RS02945	COG0488	(ABC) transporter
EP01_RS02960	COG0488	(ABC) transporter
EP01_RS03000	COG0439	Biotin carboxylase
EP01_RS03005	COG1024	Enoyl-CoA hydratase
EP01_RS03010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP01_RS03045	COG4555	ABC transporter
EP01_RS03060	COG0625	glutathione transferase activity
EP01_RS03165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EP01_RS03195	COG0583	DNA-binding transcription factor activity
EP01_RS03200	COG2234	aminopeptidase activity
EP01_RS03215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP01_RS03240	COG0071	Belongs to the small heat shock protein (HSP20) family
EP01_RS03275	COG0488	(ABC) transporter
EP01_RS03295	COG3842	ATPase activity
EP01_RS03305	COG1177	transmembrane transport
EP01_RS03310	COG2270	Major facilitator Superfamily
EP01_RS03315	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EP01_RS03325	COG1846	Transcriptional regulator
EP01_RS03330	COG1418	mRNA catabolic process
EP01_RS03355	COG1404	Belongs to the peptidase S8 family
EP01_RS03370	COG1764	response to oxidative stress
EP01_RS03375	COG2855	membrane
EP01_RS03405	COG1404	Belongs to the peptidase S8 family
EP01_RS03425	COG3119	arylsulfatase activity
EP01_RS03430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EP01_RS03450	COG0583	DNA-binding transcription factor activity
EP01_RS03465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP01_RS03485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EP01_RS03490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP01_RS03495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP01_RS03515	COG0268	Binds directly to 16S ribosomal RNA
EP01_RS03520	COG0728	peptidoglycan biosynthetic process
EP01_RS03525	COG0840	transmembrane signaling receptor activity
EP01_RS03530	COG0840	transmembrane signaling receptor activity
EP01_RS03575	COG0811	peptide transport
EP01_RS03590	COG3956	TIGRFAM MazG family protein
EP01_RS03600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EP01_RS03610	COG0577	efflux transmembrane transporter activity
EP01_RS03610	COG1136	(ABC) transporter
EP01_RS03615	COG1136	(ABC) transporter
EP01_RS03620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP01_RS03630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP01_RS03640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP01_RS03645	COG1663	tetraacyldisaccharide 4'-kinase activity
EP01_RS03650	COG1560	Kdo2-lipid A biosynthetic process
EP01_RS03675	COG2204	response regulator
EP01_RS03680	COG2205	protein histidine kinase activity
EP01_RS03685	COG0196	riboflavin kinase activity
EP01_RS03695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP01_RS03705	COG1459	type II secretion system
EP01_RS03710	COG3852	Histidine kinase
EP01_RS03715	COG2204	response regulator
EP01_RS03730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EP01_RS03745	COG0564	pseudouridine synthase activity
EP01_RS03760	COG2204	response regulator
EP01_RS03790	COG1132	(ABC) transporter
EP01_RS03795	COG0572	uridine kinase
EP01_RS03800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EP01_RS03815	COG1012	belongs to the aldehyde dehydrogenase family
EP01_RS03820	COG0784	Response regulator, receiver
EP01_RS03820	COG2198	Histidine kinase
EP01_RS03820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP01_RS03820	COG2205	protein histidine kinase activity
EP01_RS03875	COG0779	Required for maturation of 30S ribosomal subunits
EP01_RS03880	COG0195	Participates in both transcription termination and antitermination
EP01_RS03885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EP01_RS03890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EP01_RS03895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EP01_RS03900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EP01_RS03905	COG1185	polyribonucleotide nucleotidyltransferase activity
EP01_RS03910	COG0612	Peptidase, M16
EP01_RS03915	COG0756	dUTP diphosphatase activity
EP01_RS03950	COG1216	Glycosyl transferase, family 2
EP01_RS03965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EP01_RS03970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EP01_RS03975	COG1561	YicC-like family, N-terminal region
EP01_RS03980	COG0194	GDP metabolic process
EP01_RS03985	COG1758	RNA polymerase activity
EP01_RS03995	COG0784	Response regulator, receiver
EP01_RS03995	COG4191	Histidine kinase
EP01_RS04020	COG4264	IucA IucC family
EP01_RS04120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP01_RS04150	COG2096	Adenosyltransferase
EP01_RS04160	COG1333	cytochrome c biogenesis protein
EP01_RS04160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP01_RS04165	COG1333	cytochrome c biogenesis protein
EP01_RS04165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP01_RS04215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EP01_RS04220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EP01_RS04225	COG1490	D-aminoacyl-tRNA deacylase activity
EP01_RS04230	COG0427	acetyl-CoA hydrolase
EP01_RS04245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EP01_RS04250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EP01_RS04255	COG1304	FMN binding
EP01_RS04285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP01_RS04285	COG0357	Ribosomal RNA small subunit methyltransferase G
EP01_RS04300	COG0357	Ribosomal RNA small subunit methyltransferase G
EP01_RS04305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EP01_RS04310	COG0072	phenylalanine-tRNA ligase activity
EP01_RS04310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP01_RS04315	COG0776	regulation of translation
EP01_RS04355	COG0628	permease
EP01_RS04385	COG0735	belongs to the Fur family
EP01_RS04395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EP01_RS04400	COG0573	inorganic phosphate transmembrane transporter activity
EP01_RS04405	COG0581	inorganic phosphate transmembrane transporter activity
EP01_RS04410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EP01_RS04460	COG1368	sulfuric ester hydrolase activity
EP01_RS04485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EP01_RS04525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP01_RS04530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP01_RS04550	COG2070	2-Nitropropane dioxygenase
EP01_RS04570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EP01_RS04580	COG3021	interspecies interaction between organisms
EP01_RS04600	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EP01_RS04615	COG3932	Exopolysaccharide synthesis, ExoD
EP01_RS04650	COG1562	ergosterol biosynthetic process
EP01_RS04660	COG0842	Transport permease protein
EP01_RS04665	COG1131	(ABC) transporter
EP01_RS04680	COG1720	tRNA m6t6A37 methyltransferase activity
EP01_RS04690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP01_RS04690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP01_RS04705	COG1077	Cell shape determining protein MreB Mrl
EP01_RS04740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP01_RS04745	COG0583	DNA-binding transcription factor activity
EP01_RS04790	COG2076	Multidrug Resistance protein
EP01_RS04795	COG0431	NADPH-dependent FMN reductase
EP01_RS04800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EP01_RS04810	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EP01_RS04815	COG2205	protein histidine kinase activity
EP01_RS04820	COG0745	RESPONSE REGULATOR receiver
EP01_RS04855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP01_RS04860	COG2884	Cell division ATP-binding protein ftsE
EP01_RS04885	COG2171	N-acyltransferase activity
EP01_RS04895	COG0019	diaminopimelate decarboxylase activity
EP01_RS04900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EP01_RS04905	COG0517	IMP dehydrogenase activity
EP01_RS04905	COG0516	GMP reductase activity
EP01_RS04935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP01_RS04975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP01_RS05010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EP01_RS05025	COG0318	PFAM AMP-dependent synthetase and ligase
EP01_RS05035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP01_RS05040	COG0326	Molecular chaperone. Has ATPase activity
EP01_RS05045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EP01_RS05055	COG3483	tryptophan 2,3-dioxygenase activity
EP01_RS05085	COG0038	chloride channel
EP01_RS05105	COG0617	tRNA 3'-terminal CCA addition
EP01_RS05130	COG2197	response regulator
EP01_RS05140	COG0784	Response regulator, receiver
EP01_RS05140	COG2205	protein histidine kinase activity
EP01_RS05155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP01_RS05165	COG0280	phosphate acetyltransferase
EP01_RS05165	COG0281	malic enzyme
EP01_RS05175	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP01_RS05175	COG1024	Enoyl-CoA hydratase
EP01_RS05195	COG3104	oligopeptide transport
EP01_RS05235	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP01_RS05240	COG1024	Enoyl-CoA hydratase
EP01_RS05245	COG1703	isobutyryl-CoA mutase activity
EP01_RS05245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EP01_RS05245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EP01_RS05250	COG2205	protein histidine kinase activity
EP01_RS05255	COG2261	transglycosylase associated protein
EP01_RS05265	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EP01_RS05270	COG0688	phosphatidylethanolamine metabolic process
EP01_RS05280	COG0720	synthase
EP01_RS05310	COG1088	dTDP-glucose 4,6-dehydratase activity
EP01_RS05315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EP01_RS05320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EP01_RS05325	COG0840	transmembrane signaling receptor activity
EP01_RS05335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP01_RS05340	COG1131	(ABC) transporter
EP01_RS05345	COG1131	(ABC) transporter
EP01_RS05350	COG0842	Transport permease protein
EP01_RS05355	COG0842	Transport permease protein
EP01_RS05390	COG0471	metal ion transport
EP01_RS05415	COG3604	Transcriptional regulator
EP01_RS05510	COG0531	amino acid
EP01_RS05525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP01_RS05530	COG0824	Thioesterase
EP01_RS05570	COG1012	belongs to the aldehyde dehydrogenase family
EP01_RS05575	COG0037	tRNA processing
EP01_RS05580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP01_RS05585	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EP01_RS05595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP01_RS05600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EP01_RS05605	COG0802	atpase or kinase
EP01_RS05635	COG0482	sulfurtransferase activity
EP01_RS05640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP01_RS05645	COG0571	ribonuclease III activity
EP01_RS05650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EP01_RS05655	COG1160	GTP binding
EP01_RS05660	COG0733	neurotransmitter:sodium symporter activity
EP01_RS05670	COG0386	Belongs to the glutathione peroxidase family
EP01_RS05680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EP01_RS05690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP01_RS05695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP01_RS05705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EP01_RS05740	COG2166	iron-sulfur cluster assembly
EP01_RS05755	COG0217	transcriptional regulatory protein
EP01_RS05770	COG1187	pseudouridine synthase activity
EP01_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
EP01_RS05790	COG5001	Diguanylate cyclase
EP01_RS05790	COG1716	ATPase activity
EP01_RS05795	COG4166	transmembrane transport
EP01_RS05800	COG1960	acyl-CoA dehydrogenase activity
EP01_RS05805	COG1994	Peptidase M50
EP01_RS05810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EP01_RS05815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EP01_RS05845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP01_RS05850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP01_RS05850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EP01_RS05855	COG1242	4 iron, 4 sulfur cluster binding
EP01_RS05915	COG3158	transport of potassium into the cell
EP01_RS05930	COG3781	membrane
EP01_RS05955	COG4942	peptidase
EP01_RS05960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EP01_RS05965	COG0698	ribose 5-phosphate isomerase
EP01_RS05970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP01_RS05975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP01_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
EP01_RS05990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP01_RS05995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EP01_RS06025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP01_RS06030	COG1116	anion transmembrane transporter activity
EP01_RS06045	COG4974	Belongs to the 'phage' integrase family
EP01_RS06055	COG0018	arginyl-trna synthetase
EP01_RS06085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP01_RS06095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EP01_RS06110	COG1011	Hydrolase
EP01_RS06130	COG1686	Belongs to the peptidase S11 family
EP01_RS06155	COG1837	Belongs to the UPF0109 family
EP01_RS06175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP01_RS06190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EP01_RS06230	COG0037	tRNA processing
EP01_RS06240	COG0625	glutathione transferase activity
EP01_RS06280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP01_RS06310	COG0519	Catalyzes the synthesis of GMP from XMP
EP01_RS06310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EP01_RS06315	COG0516	GMP reductase activity
EP01_RS06315	COG0517	IMP dehydrogenase activity
EP01_RS06320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EP01_RS06330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP01_RS06330	COG4651	solute:proton antiporter activity
EP01_RS06340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP01_RS06375	COG0183	Belongs to the thiolase family
EP01_RS06380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP01_RS06390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP01_RS06390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP01_RS06420	COG0776	regulation of translation
EP01_RS06435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP01_RS06455	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EP01_RS06470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EP01_RS06475	COG0335	large ribosomal subunit rRNA binding
EP01_RS06480	COG0336	Belongs to the RNA methyltransferase TrmD family
EP01_RS06480	COG4752	Belongs to the RNA methyltransferase TrmD family
EP01_RS06485	COG0336	Belongs to the RNA methyltransferase TrmD family
EP01_RS06490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP01_RS06500	COG0228	four-way junction DNA binding
EP01_RS06505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EP01_RS06525	COG0842	Transport permease protein
EP01_RS06530	COG1131	(ABC) transporter
EP01_RS06535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EP01_RS06540	COG1054	Belongs to the UPF0176 family
EP01_RS06855	COG0387	Pfam Sodium calcium exchanger
EP01_RS06860	COG2900	Belongs to the SlyX family
EP01_RS06870	COG0328	RNA-DNA hybrid ribonuclease activity
EP01_RS06875	COG2197	response regulator
EP01_RS06880	COG2176	DNA-directed DNA polymerase activity
EP01_RS06895	COG0745	RESPONSE REGULATOR receiver
EP01_RS06900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP01_RS06905	COG0471	metal ion transport
EP01_RS06905	COG3273	potassium ion transport
EP01_RS06920	COG0778	Nitroreductase
EP01_RS06945	COG2197	response regulator
EP01_RS06980	COG0730	response to heat
EP01_RS06990	COG2814	Major facilitator Superfamily
EP01_RS07005	COG1418	mRNA catabolic process
EP01_RS07010	COG0784	Response regulator, receiver
EP01_RS07010	COG2205	protein histidine kinase activity
EP01_RS07020	COG1253	flavin adenine dinucleotide binding
EP01_RS07035	COG0038	chloride channel
EP01_RS07040	COG1960	acyl-CoA dehydrogenase activity
EP01_RS07050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EP01_RS07085	COG2205	protein histidine kinase activity
EP01_RS07105	COG0616	signal peptide processing
EP01_RS07110	COG0444	Belongs to the ABC transporter superfamily
EP01_RS07115	COG4608	Belongs to the ABC transporter superfamily
EP01_RS07120	COG4166	transmembrane transport
EP01_RS07125	COG0601	transmembrane transport
EP01_RS07130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP01_RS07145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP01_RS07165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP01_RS07180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP01_RS07185	COG1090	epimerase
EP01_RS07190	COG0415	Belongs to the DNA photolyase family
EP01_RS07195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP01_RS07200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP01_RS07230	COG1612	heme a metabolic process
EP01_RS07230	COG0109	protoheme IX farnesyltransferase activity
EP01_RS07245	COG0494	nUDIX hydrolase
EP01_RS07265	COG2217	Heavy metal translocating P-type atpase
EP01_RS07270	COG1937	Protein conserved in bacteria
EP01_RS07300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EP01_RS07310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP01_RS07315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP01_RS07320	COG1862	Preprotein translocase
EP01_RS07325	COG0343	queuine tRNA-ribosyltransferase activity
EP01_RS07330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EP01_RS07345	COG0069	glutamate synthase activity
EP01_RS07375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP01_RS07375	COG0723	plastoquinol--plastocyanin reductase activity
EP01_RS07415	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EP01_RS07420	COG1720	tRNA m6t6A37 methyltransferase activity
EP01_RS07425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EP01_RS07435	COG0288	reversible hydration of carbon dioxide
EP01_RS07475	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EP01_RS07495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP01_RS07495	COG4651	solute:proton antiporter activity
EP01_RS07505	COG0463	Glycosyl transferase, family 2
EP01_RS07545	COG0366	Alpha amylase catalytic
EP01_RS07560	COG1863	multisubunit Na H antiporter MnhE subunit
EP01_RS07565	COG0651	ATP synthesis coupled electron transport
EP01_RS07570	COG1006	Multisubunit Na H antiporter MnhC subunit
EP01_RS07575	COG2111	Na H antiporter
EP01_RS07575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EP01_RS07585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP01_RS07615	COG2217	Heavy metal translocating P-type atpase
EP01_RS07645	COG4974	Belongs to the 'phage' integrase family
EP01_RS07660	COG2385	sporulation resulting in formation of a cellular spore
EP01_RS07695	COG0728	peptidoglycan biosynthetic process
EP01_RS07700	COG0322	excinuclease ABC activity
EP01_RS07705	COG0556	nucleotide-excision repair
EP01_RS07725	COG0215	cysteine-tRNA ligase activity
EP01_RS07730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP01_RS07740	COG1404	Belongs to the peptidase S8 family
EP01_RS07755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EP01_RS07780	COG1192	Involved in chromosome partitioning
EP01_RS07795	COG3591	Belongs to the peptidase S1B family
EP01_RS07800	COG0784	Response regulator, receiver
EP01_RS07800	COG2205	protein histidine kinase activity
EP01_RS07815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EP01_RS07820	COG1830	Aldolase
EP01_RS07830	COG0534	Mate efflux family protein
EP01_RS07840	COG0477	Major facilitator Superfamily
EP01_RS07855	COG0633	Ferredoxin
EP01_RS07855	COG3217	Mosc domain protein beta barrel domain protein
EP01_RS07870	COG2226	methyltransferase
EP01_RS07885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EP01_RS07890	COG0084	hydrolase, TatD family'
EP01_RS07900	COG0586	Pfam SNARE associated Golgi protein
EP01_RS07925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EP01_RS07925	COG0116	Belongs to the methyltransferase superfamily
EP01_RS07945	COG0859	PFAM glycosyl transferase family 9
EP01_RS08060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EP01_RS08115	COG0745	RESPONSE REGULATOR receiver
EP01_RS08150	COG0745	RESPONSE REGULATOR receiver
EP01_RS08160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EP01_RS08165	COG0717	Belongs to the dCTP deaminase family
EP01_RS08270	COG2871	sodium ion transport
EP01_RS08275	COG0697	spore germination
EP01_RS08285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP01_RS08300	COG1469	GTP cyclohydrolase I activity
EP01_RS08305	COG0424	maF-like protein
EP01_RS08310	COG0295	cytidine deaminase activity
EP01_RS08340	COG1792	Involved in formation and maintenance of cell shape
EP01_RS08350	COG0768	penicillin binding
EP01_RS08355	COG0772	Belongs to the SEDS family
EP01_RS08385	COG3118	belongs to the thioredoxin family
EP01_RS08400	COG0758	DNA mediated transformation
EP01_RS08400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP01_RS08430	COG0686	Belongs to the AlaDH PNT family
EP01_RS08450	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EP01_RS08465	COG2255	four-way junction helicase activity
EP01_RS08470	COG0632	four-way junction helicase activity
EP01_RS08475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EP01_RS08485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EP01_RS08500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP01_RS08530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EP01_RS08535	COG0840	transmembrane signaling receptor activity
EP01_RS08540	COG0840	transmembrane signaling receptor activity
EP01_RS08550	COG0095	Lipoate-protein ligase
EP01_RS08595	COG0583	DNA-binding transcription factor activity
EP01_RS08605	COG3634	alkyl hydroperoxide reductase activity
EP01_RS08620	COG0308	aminopeptidase N
EP01_RS08625	COG0302	gtp cyclohydrolase
EP01_RS08685	COG3591	Belongs to the peptidase S1B family
EP01_RS08715	COG1132	(ABC) transporter
EP01_RS08720	COG1132	(ABC) transporter
EP01_RS08725	COG2239	Acts as a magnesium transporter
EP01_RS08770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP01_RS08780	COG2967	ApaG domain
EP01_RS08825	COG0259	pyridoxamine-phosphate oxidase activity
EP01_RS08830	COG0545	Peptidyl-prolyl cis-trans isomerase
EP01_RS08835	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EP01_RS08840	COG0709	Synthesizes selenophosphate from selenide and ATP
EP01_RS08845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP01_RS08860	COG0745	RESPONSE REGULATOR receiver
EP01_RS08865	COG2205	protein histidine kinase activity
EP01_RS08895	COG1132	(ABC) transporter
EP01_RS08900	COG2205	protein histidine kinase activity
EP01_RS08900	COG3437	response regulator, receiver
EP01_RS08900	COG4999	Histidine kinase
EP01_RS08900	COG3850	Histidine kinase
EP01_RS08930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP01_RS08960	COG4548	von Willebrand factor, type A
EP01_RS08965	COG0714	Associated with various cellular activities
EP01_RS08975	COG2010	Cytochrome c
EP01_RS09020	COG3278	Belongs to the heme-copper respiratory oxidase family
EP01_RS09025	COG2010	Cytochrome c
EP01_RS09030	COG0348	domain, Protein
EP01_RS09050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EP01_RS09060	COG0783	Belongs to the Dps family
EP01_RS09070	COG0840	transmembrane signaling receptor activity
EP01_RS09075	COG0786	glutamate:sodium symporter activity
EP01_RS09095	COG3591	Belongs to the peptidase S1B family
EP01_RS09120	COG2272	Belongs to the type-B carboxylesterase lipase family
EP01_RS09130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP01_RS09135	COG3608	succinylglutamate desuccinylase aspartoacylase
EP01_RS09135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EP01_RS09140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EP01_RS09150	COG2346	COG2346, Truncated hemoglobins
EP01_RS09180	COG0572	uridine kinase
EP01_RS09195	COG4772	TonB-dependent receptor
EP01_RS09215	COG2824	Alkylphosphonate utilization operon protein PhnA
EP01_RS09220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP01_RS09270	COG3214	Protein conserved in bacteria
EP01_RS09280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP01_RS09350	COG0210	DNA helicase
EP01_RS09355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP01_RS09390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EP01_RS09445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EP01_RS09460	COG1024	Enoyl-CoA hydratase
EP01_RS09470	COG1968	undecaprenyl-diphosphatase activity
EP01_RS09475	COG0668	transmembrane transport
EP01_RS09495	COG0860	N-Acetylmuramoyl-L-alanine amidase
EP01_RS09500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EP01_RS09505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EP01_RS09515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP01_RS09520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EP01_RS09525	COG0193	aminoacyl-tRNA hydrolase activity
EP01_RS09530	COG0012	GTP binding
EP01_RS09535	COG0154	amidase activity
EP01_RS09540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP01_RS09545	COG0601	transmembrane transport
EP01_RS09555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EP01_RS09560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP01_RS09580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EP01_RS09600	COG1228	amidohydrolase
EP01_RS09605	COG0071	Belongs to the small heat shock protein (HSP20) family
EP01_RS09630	COG0588	phosphoglycerate mutase activity
EP01_RS09635	COG0567	Dehydrogenase, E1 component
EP01_RS09640	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP01_RS09715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP01_RS09725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EP01_RS09740	COG0494	nUDIX hydrolase
EP01_RS09745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EP01_RS09750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP01_RS09755	COG0242	peptide deformylase activity
EP01_RS09845	COG2072	flavoprotein involved in K transport
EP01_RS09870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EP01_RS09875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EP01_RS09920	COG2304	oxidoreductase activity
EP01_RS09940	COG0714	Associated with various cellular activities
EP01_RS09945	COG0501	Belongs to the peptidase M48B family
EP01_RS09955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP01_RS09960	COG2088	sporulation resulting in formation of a cellular spore
EP01_RS10005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP01_RS10035	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EP01_RS10035	COG3264	Mechanosensitive ion channel
EP01_RS10055	COG0564	pseudouridine synthase activity
EP01_RS10070	COG3005	denitrification pathway
EP01_RS10075	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EP01_RS10090	COG0835	chemotaxis
EP01_RS10095	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EP01_RS10100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP01_RS10115	COG0784	Response regulator, receiver
EP01_RS10115	COG2205	protein histidine kinase activity
EP01_RS10120	COG0281	malic enzyme
EP01_RS10130	COG2353	YceI-like domain
EP01_RS10135	COG2197	response regulator
EP01_RS10140	COG2205	protein histidine kinase activity
EP01_RS10165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EP01_RS10180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP01_RS10190	COG2205	protein histidine kinase activity
EP01_RS10190	COG0784	Response regulator, receiver
EP01_RS10210	COG1690	Belongs to the RtcB family
EP01_RS10225	COG1027	Aspartate ammonia-lyase
EP01_RS10245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EP01_RS10345	COG1368	sulfuric ester hydrolase activity
EP01_RS10355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP01_RS10365	COG0277	FAD linked oxidase domain protein
EP01_RS10375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP01_RS10395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP01_RS10400	COG1295	ribonuclease BN
EP01_RS10420	COG2195	Cleaves the N-terminal amino acid of tripeptides
EP01_RS10445	COG0583	DNA-binding transcription factor activity
EP01_RS10450	COG0702	epimerase
EP01_RS10480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EP01_RS10515	COG2942	2-epimerase
EP01_RS10525	COG0519	Catalyzes the synthesis of GMP from XMP
EP01_RS10525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EP01_RS10540	COG1960	acyl-CoA dehydrogenase activity
EP01_RS10580	COG0488	(ABC) transporter
EP01_RS10615	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EP01_RS10625	COG5002	protein histidine kinase activity
EP01_RS10630	COG0784	Response regulator, receiver
EP01_RS10635	COG2205	protein histidine kinase activity
EP01_RS10635	COG2198	Histidine kinase
EP01_RS10635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP01_RS10635	COG0784	Response regulator, receiver
EP01_RS10650	COG5507	3-demethylubiquinone-9 3-methyltransferase
EP01_RS10665	COG2814	Major facilitator Superfamily
EP01_RS10720	COG0708	Exodeoxyribonuclease III
EP01_RS10755	COG0693	protein deglycase activity
EP01_RS10760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP01_RS10760	COG2205	protein histidine kinase activity
EP01_RS10770	COG1061	Type III restriction enzyme res subunit
EP01_RS10775	COG2850	peptidyl-arginine hydroxylation
EP01_RS10780	COG1733	regulation of RNA biosynthetic process
EP01_RS10785	COG1741	Belongs to the pirin family
EP01_RS10835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EP01_RS10870	COG2249	NAD(P)H dehydrogenase (quinone) activity
EP01_RS10900	COG0538	isocitrate dehydrogenase activity
EP01_RS10935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP01_RS10940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EP01_RS10945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP01_RS10950	COG1100	Small GTP-binding protein
EP01_RS10955	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP01_RS11005	COG3089	Belongs to the UPF0270 family
EP01_RS11025	COG3852	Histidine kinase
EP01_RS11030	COG2205	protein histidine kinase activity
EP01_RS11030	COG0784	Response regulator, receiver
EP01_RS11040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EP01_RS11045	COG0740	serine-type endopeptidase activity
EP01_RS11050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP01_RS11085	COG0003	Pfam Anion-transporting ATPase
EP01_RS11095	COG0544	peptidyl-prolyl cis-trans isomerase activity
EP01_RS11170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP01_RS11180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EP01_RS11200	COG0052	Belongs to the universal ribosomal protein uS2 family
EP01_RS11205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EP01_RS11210	COG0528	UMP kinase activity
EP01_RS11215	COG0233	cytoplasmic translational termination
EP01_RS11220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP01_RS11225	COG4589	Belongs to the CDS family
EP01_RS11230	COG0750	zinc metalloprotease
EP01_RS11235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EP01_RS11240	COG2894	cell division
EP01_RS11250	COG0564	pseudouridine synthase activity
EP01_RS11255	COG1496	oxidoreductase activity
EP01_RS11260	COG2094	Belongs to the DNA glycosylase MPG family
EP01_RS11265	COG1272	protein, Hemolysin III
EP01_RS11275	COG0626	cystathionine gamma-synthase activity
EP01_RS11315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP01_RS11320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP01_RS11330	COG1127	ABC transporter
EP01_RS11335	COG1127	ABC transporter
EP01_RS11340	COG0045	succinate-CoA ligase (ADP-forming) activity
EP01_RS11345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EP01_RS11370	COG1136	(ABC) transporter
EP01_RS11425	COG0105	UTP biosynthetic process
EP01_RS11430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EP01_RS11440	COG1426	Protein conserved in bacteria
EP01_RS11455	COG0633	Ferredoxin
EP01_RS11460	COG2176	DNA-directed DNA polymerase activity
EP01_RS11470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP01_RS11470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EP01_RS11490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP01_RS11510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EP01_RS11520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EP01_RS11525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EP01_RS11530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EP01_RS11555	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EP01_RS11570	COG1404	Belongs to the peptidase S8 family
EP01_RS11575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP01_RS11580	COG0439	Biotin carboxylase
EP01_RS11595	COG0805	protein transport
EP01_RS11615	COG0612	Peptidase, M16
EP01_RS11620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP01_RS11625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EP01_RS11630	COG0484	heat shock protein binding
EP01_RS11650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP01_RS11690	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EP01_RS11695	COG0714	Associated with various cellular activities
EP01_RS11700	COG1007	ATP synthesis coupled electron transport
EP01_RS11715	COG0713	ATP synthesis coupled electron transport
EP01_RS11725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EP01_RS11730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP01_RS11745	COG1472	Belongs to the glycosyl hydrolase 3 family
EP01_RS11750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP01_RS11755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EP01_RS11760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EP01_RS11765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EP01_RS11770	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP01_RS11775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EP01_RS11795	COG1192	Involved in chromosome partitioning
EP01_RS11805	COG0357	Ribosomal RNA small subunit methyltransferase G
EP01_RS11810	COG0445	tRNA wobble uridine modification
EP01_RS11815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EP01_RS11825	COG0706	membrane insertase activity
EP01_RS11835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP01_RS11845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP01_RS11850	COG0187	DNA topoisomerase II activity
EP01_RS11855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EP01_RS11875	COG0356	it plays a direct role in the translocation of protons across the membrane
EP01_RS11880	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP01_RS11895	COG0789	Transcriptional regulator
EP01_RS11905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EP01_RS11910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP01_RS11920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP01_RS11930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EP01_RS11935	COG2086	electron transfer activity
EP01_RS11945	COG1053	succinate dehydrogenase
EP01_RS11975	COG0360	Binds together with S18 to 16S ribosomal RNA
EP01_RS11985	COG0359	binds to the 23S rRNA
EP01_RS12005	COG0305	Participates in initiation and elongation during chromosome replication
EP01_RS12015	COG0602	queuosine metabolic process
EP01_RS12040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EP01_RS12045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP01_RS12050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EP01_RS12060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EP01_RS12095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP01_RS12100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP01_RS12105	COG0154	amidase activity
EP01_RS12110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP01_RS12115	COG0248	Ppx GppA phosphatase
EP01_RS12135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EP01_RS12145	COG0254	rRNA binding
EP01_RS12150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EP01_RS12155	COG2890	protein-(glutamine-N5) methyltransferase activity
EP01_RS12160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EP01_RS12190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EP01_RS12205	COG0586	Pfam SNARE associated Golgi protein
EP01_RS12230	COG0590	tRNA wobble adenosine to inosine editing
EP01_RS12240	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP01_RS12305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EP01_RS12310	COG0459	protein refolding
EP01_RS12325	COG2201	protein-glutamate methylesterase activity
EP01_RS12400	COG0840	transmembrane signaling receptor activity
EP01_RS12405	COG0037	tRNA processing
EP01_RS12405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EP01_RS12415	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP01_RS12425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP01_RS12430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP01_RS12445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP01_RS12455	COG0527	aspartate kinase activity
EP01_RS12460	COG0778	Nitroreductase
EP01_RS12465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP01_RS12470	COG1217	gtp-binding protein TYPA
EP01_RS12490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP01_RS12500	COG0671	phosphoesterase, PA-phosphatase related
EP01_RS12505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP01_RS12515	COG1472	Belongs to the glycosyl hydrolase 3 family
EP01_RS12540	COG3876	Protein conserved in bacteria
EP01_RS12545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EP01_RS12565	COG0668	transmembrane transport
EP01_RS12570	COG1132	(ABC) transporter
EP01_RS12590	COG1970	mechanosensitive ion channel activity
EP01_RS12605	COG2884	Cell division ATP-binding protein ftsE
EP01_RS12610	COG2177	Part of the ABC transporter FtsEX involved in
EP01_RS12620	COG0793	Belongs to the peptidase S41A family
EP01_RS12640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP01_RS12650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP01_RS12655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EP01_RS12660	COG0823	Involved in the tonB-independent uptake of proteins
EP01_RS12690	COG0719	Fe-S assembly protein
EP01_RS12695	COG0396	ATPase activity
EP01_RS12700	COG0719	Fe-S assembly protein
EP01_RS12705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP01_RS12735	COG1570	exodeoxyribonuclease VII activity
EP01_RS12740	COG1722	exodeoxyribonuclease VII activity
EP01_RS12745	COG0142	geranyltranstransferase activity
EP01_RS12750	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EP01_RS12760	COG0006	proline dipeptidase activity
EP01_RS12785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EP01_RS12800	COG1077	Cell shape determining protein MreB Mrl
EP01_RS12825	COG2003	Belongs to the UPF0758 family
EP01_RS12845	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
EP01_RS12870	COG2766	serine protein kinase
EP01_RS12875	COG2718	Belongs to the UPF0229 family
EP01_RS12880	COG2719	SpoVR family
EP01_RS12895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EP01_RS12900	COG0513	Belongs to the DEAD box helicase family
EP01_RS12910	COG0861	Integral membrane protein TerC family
EP01_RS12920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EP01_RS12930	COG0358	DNA primase activity
EP01_RS12955	COG2031	fatty acid transporter
EP01_RS12990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EP01_RS13000	COG0322	excinuclease ABC activity
EP01_RS13020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP01_RS13055	COG0509	glycine decarboxylation via glycine cleavage system
EP01_RS13075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP01_RS13080	COG0653	protein targeting
EP01_RS13115	COG0318	PFAM AMP-dependent synthetase and ligase
EP01_RS13120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP01_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
EP01_RS13155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EP01_RS13160	COG1845	cytochrome c oxidase, subunit III
EP01_RS13170	COG0109	protoheme IX farnesyltransferase activity
EP01_RS13195	COG2032	superoxide dismutase activity
EP01_RS13200	COG2373	Large extracellular alpha-helical protein
EP01_RS13205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP01_RS13235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP01_RS13245	COG0604	alcohol dehydrogenase
EP01_RS13275	COG3135	benzoate transporter
EP01_RS13280	COG0357	Ribosomal RNA small subunit methyltransferase G
EP01_RS13315	COG0724	RNA recognition motif
EP01_RS13320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP01_RS13325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP01_RS13335	COG0513	Belongs to the DEAD box helicase family
EP01_RS13340	COG1393	Belongs to the ArsC family
EP01_RS13345	COG0386	Belongs to the glutathione peroxidase family
EP01_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
EP01_RS13405	COG2807	transmembrane transport
EP01_RS13430	COG1666	GTP binding
EP01_RS13435	COG0724	RNA recognition motif
EP01_RS13445	COG1136	(ABC) transporter
EP01_RS13450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EP01_RS13455	COG0009	L-threonylcarbamoyladenylate synthase
EP01_RS13480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP01_RS13485	COG1393	Belongs to the ArsC family
EP01_RS13490	COG0010	Belongs to the arginase family
EP01_RS13495	COG4166	transmembrane transport
EP01_RS13500	COG4174	ABC transporter (Permease)
EP01_RS13505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP01_RS13520	COG1166	arginine decarboxylase activity
EP01_RS13525	COG0495	leucyl-tRNA aminoacylation
EP01_RS13535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EP01_RS13540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP01_RS13560	COG0745	RESPONSE REGULATOR receiver
EP01_RS13585	COG0546	phosphoglycolate phosphatase activity
EP01_RS13610	COG0587	DNA-directed DNA polymerase activity
EP01_RS13635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EP01_RS13660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EP01_RS13670	COG2814	Major facilitator Superfamily
EP01_RS13685	COG0739	heme binding
EP01_RS13705	COG0183	Belongs to the thiolase family
EP01_RS13725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP01_RS13730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP01_RS13780	COG0848	biopolymer transport protein
EP01_RS13785	COG0811	peptide transport
EP01_RS13790	COG0583	DNA-binding transcription factor activity
EP01_RS13795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP01_RS13800	COG0557	exoribonuclease II activity
EP01_RS13815	COG0745	RESPONSE REGULATOR receiver
EP01_RS13825	COG5006	permease, DMT superfamily
EP01_RS13840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EP01_RS13865	COG1079	Belongs to the binding-protein-dependent transport system permease family
EP01_RS13870	COG4603	Belongs to the binding-protein-dependent transport system permease family
EP01_RS13875	COG3845	ABC transporter
EP01_RS13880	COG1744	ABC transporter substrate-binding protein PnrA-like
EP01_RS13885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP01_RS13895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EP01_RS13940	COG0525	valine-tRNA ligase activity
EP01_RS13965	COG1872	DUF167
EP01_RS13975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EP01_RS13980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EP01_RS13990	COG0726	polysaccharide deacetylase
EP01_RS13995	COG0424	maF-like protein
EP01_RS14020	COG1716	ATPase activity
EP01_RS14060	COG1183	phosphatidylcholine synthase activity
EP01_RS14065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EP01_RS14095	COG0101	tRNA pseudouridine synthase activity
EP01_RS14100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EP01_RS14105	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EP01_RS14140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP01_RS14150	COG1408	metallophosphoesterase
EP01_RS14155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP01_RS14180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EP01_RS14185	COG1546	Belongs to the CinA family
EP01_RS14185	COG1058	Belongs to the CinA family
EP01_RS14190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EP01_RS14200	COG2134	cdp-diacylglycerol pyrophosphatase
EP01_RS14220	COG0386	Belongs to the glutathione peroxidase family
EP01_RS14240	COG2267	carboxylic ester hydrolase activity
EP01_RS14265	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EP01_RS14275	COG1595	DNA-templated transcription, initiation
EP01_RS14285	COG3047	cAMP biosynthetic process
EP01_RS14285	COG2885	chlorophyll binding
EP01_RS14315	COG2154	pterin-4-alpha-carbinolamine dehydratase
EP01_RS14355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EP01_RS14360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EP01_RS14365	COG1064	alcohol dehydrogenase
EP01_RS14375	COG0583	DNA-binding transcription factor activity
EP01_RS14380	COG0583	DNA-binding transcription factor activity
EP01_RS14415	COG0596	Alpha beta hydrolase
EP01_RS14445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EP01_RS14450	COG0071	Belongs to the small heat shock protein (HSP20) family
EP01_RS14465	COG0517	IMP dehydrogenase activity
EP01_RS14475	COG0826	peptidase U32
EP01_RS14485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EP01_RS14495	COG0039	L-malate dehydrogenase activity
EP01_RS14505	COG0693	protein deglycase activity
EP01_RS14515	COG0840	transmembrane signaling receptor activity
EP01_RS14525	COG2356	endonuclease I
EP01_RS14555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EP01_RS14560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EP01_RS14565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EP01_RS14575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP01_RS14585	COG0644	oxidoreductase
EP01_RS14585	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EP01_RS14610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP01_RS14620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP01_RS14640	COG0312	modulator of DNA gyrase
EP01_RS14645	COG0312	modulator of DNA gyrase
EP01_RS14665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EP01_RS14675	COG0793	Belongs to the peptidase S41A family
EP01_RS14725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EP01_RS14730	COG1324	tolerance protein
EP01_RS14735	COG1253	flavin adenine dinucleotide binding
EP01_RS14760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP01_RS14765	COG0514	ATP-dependent DNA helicase (RecQ)
EP01_RS14775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EP01_RS14795	COG3591	Belongs to the peptidase S1B family
EP01_RS14800	COG0488	(ABC) transporter
EP01_RS14845	COG3384	dioxygenase
EP01_RS14855	COG0583	DNA-binding transcription factor activity
EP01_RS14865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EP01_RS14870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EP01_RS14875	COG2062	phosphohistidine phosphatase, SixA
EP01_RS14890	COG0248	Ppx GppA phosphatase
EP01_RS14900	COG0704	Plays a role in the regulation of phosphate uptake
EP01_RS14905	COG0745	RESPONSE REGULATOR receiver
EP01_RS14910	COG5002	protein histidine kinase activity
EP01_RS14960	COG4106	trans-aconitate 2-methyltransferase activity
EP01_RS14965	COG0598	Magnesium transport protein CorA
EP01_RS14970	COG1073	alpha beta
EP01_RS15005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EP01_RS15010	COG0470	DNA polymerase III
EP01_RS15015	COG0084	hydrolase, TatD family'
EP01_RS15050	COG0126	phosphoglycerate kinase activity
EP01_RS15055	COG0149	triose-phosphate isomerase activity
EP01_RS15070	COG0017	Asparaginyl-tRNA synthetase
EP01_RS15075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP01_RS15085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP01_RS15100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP01_RS15105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EP01_RS15130	COG0616	signal peptide processing
EP01_RS15160	COG1840	ABC-type Fe3 transport system, periplasmic component
EP01_RS15170	COG1580	Controls the rotational direction of flagella during chemotaxis
EP01_RS15175	COG0612	Peptidase, M16
EP01_RS15190	COG0583	DNA-binding transcription factor activity
EP01_RS15195	COG0840	transmembrane signaling receptor activity
EP01_RS15240	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EP01_RS15255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP01_RS15260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EP01_RS15270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP01_RS15270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EP01_RS15290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EP01_RS15300	COG0124	histidyl-tRNA synthetase
EP01_RS15315	COG4181	ATPase activity
EP01_RS15385	COG0741	lytic transglycosylase activity
EP01_RS15385	COG1388	LysM domain
EP01_RS15395	COG0583	DNA-binding transcription factor activity
EP01_RS15415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP01_RS15420	COG0489	protein tyrosine kinase activity
EP01_RS15445	COG2832	Protein of unknown function (DUF454)
EP01_RS15460	COG0423	glycine-tRNA ligase activity
EP01_RS15480	COG0574	Belongs to the PEP-utilizing enzyme family
EP01_RS15480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP01_RS15485	COG0753	catalase activity
EP01_RS15500	COG1196	nuclear chromosome segregation
EP01_RS15520	COG0778	Nitroreductase
EP01_RS15525	COG1959	2 iron, 2 sulfur cluster binding
EP01_RS15575	COG0702	epimerase
EP01_RS15615	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EP01_RS15620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EP01_RS15625	COG1418	mRNA catabolic process
EP01_RS15630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EP01_RS15640	COG0596	Alpha beta hydrolase
EP01_RS15645	COG0316	Belongs to the HesB IscA family
EP01_RS15650	COG1104	cysteine desulfurase activity
EP01_RS15660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP01_RS15665	COG0539	negative regulation of cytoplasmic translation
EP01_RS15680	COG1960	acyl-CoA dehydrogenase activity
EP01_RS15690	COG5599	Phosphatase
EP01_RS15700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EP01_RS15700	COG0116	Belongs to the methyltransferase superfamily
EP01_RS15705	COG1704	LemA family
EP01_RS15710	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EP01_RS15760	COG1671	Belongs to the UPF0178 family
EP01_RS15800	COG1940	carbohydrate kinase activity
EP01_RS15810	COG3842	ATPase activity
EP01_RS15815	COG3833	ABC-type maltose transport systems, permease component
EP01_RS15820	COG1175	transmembrane transport
EP01_RS15830	COG4580	involved in the transport of maltose and maltodextrins
EP01_RS15840	COG1741	Belongs to the pirin family
EP01_RS15845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP01_RS15860	COG0783	Belongs to the Dps family
EP01_RS15915	COG1012	belongs to the aldehyde dehydrogenase family
EP01_RS15920	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP01_RS15930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EP01_RS15935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EP01_RS15940	COG5002	protein histidine kinase activity
EP01_RS15965	COG0473	3-isopropylmalate dehydrogenase activity
EP01_RS16010	COG1122	ATPase activity
EP01_RS16040	COG1193	negative regulation of DNA recombination
EP01_RS16045	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EP01_RS16065	COG1404	Belongs to the peptidase S8 family
EP01_RS16095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EP01_RS16100	COG4968	Prepilin-type N-terminal cleavage methylation domain
EP01_RS16120	COG0484	heat shock protein binding
EP01_RS16125	COG0443	Heat shock 70 kDa protein
EP01_RS16130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP01_RS16145	COG2391	methyltransferase activity
EP01_RS16160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP01_RS16175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP01_RS16195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP01_RS16205	COG3012	SEC-C Motif Domain Protein
EP01_RS16210	COG4221	oxidoreductase activity
EP01_RS16240	COG0564	pseudouridine synthase activity
EP01_RS16265	COG0271	Belongs to the BolA IbaG family
EP01_RS16280	COG0488	(ABC) transporter
EP01_RS16295	COG0784	Response regulator, receiver
EP01_RS16295	COG2205	protein histidine kinase activity
EP01_RS16310	COG0024	Methionine aminopeptidase
EP01_RS16315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP01_RS16320	COG0840	transmembrane signaling receptor activity
EP01_RS16330	COG4335	DNA alkylation repair
EP01_RS16340	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EP01_RS16345	COG0745	RESPONSE REGULATOR receiver
EP01_RS16380	COG4221	oxidoreductase activity
EP01_RS16385	COG0583	DNA-binding transcription factor activity
EP01_RS16410	COG0840	transmembrane signaling receptor activity
EP01_RS16460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP01_RS16460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP01_RS16490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP01_RS16495	COG0006	proline dipeptidase activity
EP01_RS16535	COG2205	protein histidine kinase activity
EP01_RS16535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP01_RS16540	COG0564	pseudouridine synthase activity
EP01_RS16590	COG0513	Belongs to the DEAD box helicase family
EP01_RS16595	COG2996	Protein conserved in bacteria
EP01_RS16600	COG0724	RNA recognition motif
EP01_RS16620	COG2032	superoxide dismutase activity
EP01_RS16670	COG0513	Belongs to the DEAD box helicase family
EP01_RS16680	COG0488	(ABC) transporter
EP01_RS16690	COG0741	lytic transglycosylase activity
EP01_RS16690	COG1388	LysM domain
EP01_RS16695	COG4786	Flagellar basal body rod
EP01_RS16700	COG4786	Flagellar basal body rod
EP01_RS16705	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
EP01_RS16715	COG1706	bacterial-type flagellum-dependent cell motility
EP01_RS16740	COG1256	bacterial-type flagellum assembly
EP01_RS16755	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
EP01_RS16770	COG1575	Belongs to the MenA family. Type 1 subfamily
EP01_RS16780	COG0318	PFAM AMP-dependent synthetase and ligase
EP01_RS16810	COG0824	Thioesterase
EP01_RS16815	COG0142	geranyltranstransferase activity
EP01_RS16825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EP01_RS16840	COG0372	Belongs to the citrate synthase family
EP01_RS16870	COG0537	adenosine 5'-monophosphoramidase activity
EP01_RS16885	COG2070	2-Nitropropane dioxygenase
EP01_RS16905	COG2198	Histidine kinase
EP01_RS16905	COG0784	Response regulator, receiver
EP01_RS16905	COG0643	Histidine kinase
EP01_RS16910	COG0835	chemotaxis
EP01_RS16915	COG2201	protein-glutamate methylesterase activity
EP01_RS16940	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP01_RS16945	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EP01_RS16965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP01_RS16985	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EP01_RS16990	COG0784	Response regulator, receiver
EP01_RS16990	COG2205	protein histidine kinase activity
EP01_RS17015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP01_RS17030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP01_RS17040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EP01_RS17055	COG1516	flagellar protein fliS
EP01_RS17080	COG0859	PFAM glycosyl transferase family 9
EP01_RS17100	COG0742	ribosomal rna small subunit methyltransferase
EP01_RS17105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EP01_RS17110	COG0436	Aminotransferase
EP01_RS17130	COG5640	endopeptidase activity
EP01_RS17150	COG2885	chlorophyll binding
EP01_RS17165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EP01_RS17170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP01_RS17175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EP01_RS17205	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EP01_RS17220	COG1846	Transcriptional regulator
EP01_RS17235	COG0024	Methionine aminopeptidase
EP01_RS17240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EP01_RS17250	COG0494	nUDIX hydrolase
EP01_RS17260	COG1272	protein, Hemolysin III
EP01_RS17290	COG0840	transmembrane signaling receptor activity
EP01_RS17360	COG0484	heat shock protein binding
EP01_RS17370	COG0509	glycine decarboxylation via glycine cleavage system
EP01_RS17375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EP01_RS17410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP01_RS17410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP01_RS17415	COG2814	Major facilitator Superfamily
EP01_RS17445	COG0312	modulator of DNA gyrase
EP01_RS17450	COG0312	modulator of DNA gyrase
EP01_RS17460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EP01_RS17495	COG1136	(ABC) transporter
EP01_RS17495	COG0577	efflux transmembrane transporter activity
EP01_RS17505	COG0776	regulation of translation
EP01_RS17520	COG0494	nUDIX hydrolase
EP01_RS17525	COG0167	dihydroorotate dehydrogenase activity
EP01_RS17530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EP01_RS17545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EP01_RS17545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP01_RS17555	COG1047	Peptidyl-prolyl cis-trans
EP01_RS17585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP01_RS17605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP01_RS17640	COG0166	Belongs to the GPI family
EP01_RS17715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP01_RS17735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EP01_RS17755	COG0321	lipoyl(octanoyl) transferase activity
EP01_RS17770	COG2365	Tyrosine phosphatase family
EP01_RS17810	COG1489	DNA binding
EP01_RS17840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP01_RS17840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP01_RS17870	COG0148	phosphopyruvate hydratase activity
EP01_RS17900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP01_RS17900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EP01_RS17915	COG2204	response regulator
EP01_RS17920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EP01_RS17925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EP01_RS17930	COG0504	CTP synthase activity
EP01_RS17935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EP01_RS17935	COG0517	IMP dehydrogenase activity
EP01_RS17945	COG3708	Transcriptional regulator
EP01_RS17950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP01_RS18015	COG1126	abc transporter atp-binding protein
EP01_RS18020	COG0765	amino acid transport
EP01_RS18035	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EP01_RS18075	COG0811	peptide transport
EP01_RS18100	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EP01_RS18110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EP01_RS18135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EP01_RS18140	COG0481	GTPase activity
EP01_RS18145	COG0681	Belongs to the peptidase S26 family
EP01_RS18155	COG0681	Belongs to the peptidase S26 family
EP01_RS18160	COG0540	Belongs to the ATCase OTCase family
EP01_RS18165	COG0505	Belongs to the CarA family
EP01_RS18175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EP01_RS18185	COG1131	(ABC) transporter
EP01_RS18195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EP01_RS18235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EP01_RS18265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EP01_RS18290	COG4251	negative regulation of phosphorylation
EP01_RS18315	COG0789	Transcriptional regulator
EP01_RS18360	COG0840	transmembrane signaling receptor activity
EP01_RS18375	COG1546	Belongs to the CinA family
EP01_RS18375	COG1058	Belongs to the CinA family