locus-tag	class	description
BD_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BD_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BD_RS00020	COG0187	DNA topoisomerase II activity
BD_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BD_RS00045	COG0356	it plays a direct role in the translocation of protons across the membrane
BD_RS00050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BD_RS00065	COG0789	Transcriptional regulator
BD_RS00075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BD_RS00080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BD_RS00090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BD_RS00100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BD_RS00105	COG2086	electron transfer activity
BD_RS00115	COG1053	succinate dehydrogenase
BD_RS00145	COG0360	Binds together with S18 to 16S ribosomal RNA
BD_RS00155	COG0359	binds to the 23S rRNA
BD_RS00175	COG0305	Participates in initiation and elongation during chromosome replication
BD_RS00185	COG0602	queuosine metabolic process
BD_RS00210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BD_RS00215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BD_RS00220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BD_RS00230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BD_RS00265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BD_RS00270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BD_RS00275	COG0154	amidase activity
BD_RS00280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BD_RS00285	COG0248	Ppx GppA phosphatase
BD_RS00305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BD_RS00315	COG0254	rRNA binding
BD_RS00320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BD_RS00325	COG2890	protein-(glutamine-N5) methyltransferase activity
BD_RS00330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BD_RS00360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BD_RS00375	COG0586	Pfam SNARE associated Golgi protein
BD_RS00400	COG0590	tRNA wobble adenosine to inosine editing
BD_RS00410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BD_RS00475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BD_RS00480	COG0459	protein refolding
BD_RS00495	COG2201	protein-glutamate methylesterase activity
BD_RS00570	COG0840	transmembrane signaling receptor activity
BD_RS00575	COG0037	tRNA processing
BD_RS00575	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BD_RS00585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BD_RS00595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BD_RS00600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BD_RS00615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BD_RS00625	COG0527	aspartate kinase activity
BD_RS00630	COG0778	Nitroreductase
BD_RS00635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BD_RS00640	COG1217	gtp-binding protein TYPA
BD_RS00660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BD_RS00670	COG0671	phosphoesterase, PA-phosphatase related
BD_RS00675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BD_RS00685	COG1472	Belongs to the glycosyl hydrolase 3 family
BD_RS00710	COG3876	Protein conserved in bacteria
BD_RS00715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BD_RS00735	COG0668	transmembrane transport
BD_RS00740	COG1132	(ABC) transporter
BD_RS00760	COG1970	mechanosensitive ion channel activity
BD_RS00775	COG2884	Cell division ATP-binding protein ftsE
BD_RS00780	COG2177	Part of the ABC transporter FtsEX involved in
BD_RS00790	COG0793	Belongs to the peptidase S41A family
BD_RS00810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BD_RS00820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BD_RS00825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BD_RS00830	COG0823	Involved in the tonB-independent uptake of proteins
BD_RS00860	COG0719	Fe-S assembly protein
BD_RS00865	COG0396	ATPase activity
BD_RS00870	COG0719	Fe-S assembly protein
BD_RS00875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BD_RS00910	COG1570	exodeoxyribonuclease VII activity
BD_RS00915	COG1722	exodeoxyribonuclease VII activity
BD_RS00920	COG0142	geranyltranstransferase activity
BD_RS00925	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BD_RS00935	COG0006	proline dipeptidase activity
BD_RS00960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BD_RS00975	COG1077	Cell shape determining protein MreB Mrl
BD_RS01000	COG2003	Belongs to the UPF0758 family
BD_RS01020	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BD_RS01045	COG2766	serine protein kinase
BD_RS01050	COG2718	Belongs to the UPF0229 family
BD_RS01055	COG2719	SpoVR family
BD_RS01070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BD_RS01075	COG0513	Belongs to the DEAD box helicase family
BD_RS01085	COG0861	Integral membrane protein TerC family
BD_RS01095	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BD_RS01105	COG0358	DNA primase activity
BD_RS01130	COG2031	fatty acid transporter
BD_RS01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BD_RS01175	COG0322	excinuclease ABC activity
BD_RS01195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BD_RS01230	COG0509	glycine decarboxylation via glycine cleavage system
BD_RS01250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BD_RS01255	COG0653	protein targeting
BD_RS01290	COG0318	PFAM AMP-dependent synthetase and ligase
BD_RS01295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BD_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
BD_RS01330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BD_RS01335	COG1845	cytochrome c oxidase, subunit III
BD_RS01345	COG0109	protoheme IX farnesyltransferase activity
BD_RS01370	COG2032	superoxide dismutase activity
BD_RS01375	COG2373	Large extracellular alpha-helical protein
BD_RS01380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BD_RS01410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BD_RS01420	COG0604	alcohol dehydrogenase
BD_RS01450	COG3135	benzoate transporter
BD_RS01455	COG0357	Ribosomal RNA small subunit methyltransferase G
BD_RS01490	COG0724	RNA recognition motif
BD_RS01495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BD_RS01500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BD_RS01510	COG0513	Belongs to the DEAD box helicase family
BD_RS01520	COG0386	Belongs to the glutathione peroxidase family
BD_RS01525	COG1028	Short-chain dehydrogenase reductase Sdr
BD_RS01560	COG2807	transmembrane transport
BD_RS01585	COG1666	GTP binding
BD_RS01590	COG0724	RNA recognition motif
BD_RS01600	COG1136	(ABC) transporter
BD_RS01605	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BD_RS01610	COG0009	L-threonylcarbamoyladenylate synthase
BD_RS01635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BD_RS01640	COG1393	Belongs to the ArsC family
BD_RS01645	COG0010	Belongs to the arginase family
BD_RS01650	COG4166	transmembrane transport
BD_RS01655	COG4174	ABC transporter (Permease)
BD_RS01660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BD_RS01675	COG1166	arginine decarboxylase activity
BD_RS01680	COG0495	leucyl-tRNA aminoacylation
BD_RS01690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BD_RS01695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BD_RS01715	COG0745	RESPONSE REGULATOR receiver
BD_RS01740	COG0546	phosphoglycolate phosphatase activity
BD_RS01765	COG0587	DNA-directed DNA polymerase activity
BD_RS01790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BD_RS01815	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BD_RS01825	COG2814	Major facilitator Superfamily
BD_RS01840	COG0739	heme binding
BD_RS01860	COG0183	Belongs to the thiolase family
BD_RS01880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BD_RS01885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BD_RS01935	COG0848	biopolymer transport protein
BD_RS01940	COG0811	peptide transport
BD_RS01945	COG0583	DNA-binding transcription factor activity
BD_RS01950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BD_RS01955	COG0557	exoribonuclease II activity
BD_RS01970	COG0745	RESPONSE REGULATOR receiver
BD_RS01980	COG5006	permease, DMT superfamily
BD_RS01995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BD_RS02025	COG1079	Belongs to the binding-protein-dependent transport system permease family
BD_RS02030	COG4603	Belongs to the binding-protein-dependent transport system permease family
BD_RS02035	COG3845	ABC transporter
BD_RS02040	COG1744	ABC transporter substrate-binding protein PnrA-like
BD_RS02045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD_RS02050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BD_RS02055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BD_RS02100	COG0525	valine-tRNA ligase activity
BD_RS02125	COG1872	DUF167
BD_RS02135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BD_RS02140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BD_RS02150	COG0726	polysaccharide deacetylase
BD_RS02155	COG0424	maF-like protein
BD_RS02180	COG1716	ATPase activity
BD_RS02220	COG1183	phosphatidylcholine synthase activity
BD_RS02225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BD_RS02255	COG0101	tRNA pseudouridine synthase activity
BD_RS02260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BD_RS02265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BD_RS02300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BD_RS02310	COG1408	metallophosphoesterase
BD_RS02315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BD_RS02340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BD_RS02345	COG1058	Belongs to the CinA family
BD_RS02345	COG1546	Belongs to the CinA family
BD_RS02350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BD_RS02360	COG3189	MarR family transcriptional regulator
BD_RS02370	COG2134	cdp-diacylglycerol pyrophosphatase
BD_RS02390	COG0386	Belongs to the glutathione peroxidase family
BD_RS02415	COG0741	lytic transglycosylase activity
BD_RS02415	COG1388	LysM domain
BD_RS02420	COG4786	Flagellar basal body rod
BD_RS02425	COG4786	Flagellar basal body rod
BD_RS02430	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
BD_RS02440	COG1706	bacterial-type flagellum-dependent cell motility
BD_RS02465	COG1256	bacterial-type flagellum assembly
BD_RS02480	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BD_RS02495	COG1575	Belongs to the MenA family. Type 1 subfamily
BD_RS02505	COG0318	PFAM AMP-dependent synthetase and ligase
BD_RS02535	COG0824	Thioesterase
BD_RS02540	COG0142	geranyltranstransferase activity
BD_RS02550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BD_RS02565	COG0372	Belongs to the citrate synthase family
BD_RS02595	COG0537	adenosine 5'-monophosphoramidase activity
BD_RS02630	COG0784	Response regulator, receiver
BD_RS02630	COG0643	Histidine kinase
BD_RS02630	COG2198	Histidine kinase
BD_RS02635	COG0835	chemotaxis
BD_RS02640	COG2201	protein-glutamate methylesterase activity
BD_RS02665	COG1181	Belongs to the D-alanine--D-alanine ligase family
BD_RS02670	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BD_RS02690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BD_RS02710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BD_RS02715	COG2205	protein histidine kinase activity
BD_RS02715	COG0784	Response regulator, receiver
BD_RS02750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BD_RS02765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BD_RS02775	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BD_RS02790	COG1516	flagellar protein fliS
BD_RS02815	COG0859	PFAM glycosyl transferase family 9
BD_RS02830	COG0745	RESPONSE REGULATOR receiver
BD_RS02835	COG0742	ribosomal rna small subunit methyltransferase
BD_RS02840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BD_RS02845	COG0436	Aminotransferase
BD_RS02865	COG5640	endopeptidase activity
BD_RS02885	COG2885	chlorophyll binding
BD_RS02900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BD_RS02905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BD_RS02910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BD_RS02940	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BD_RS02955	COG1846	Transcriptional regulator
BD_RS02970	COG0024	Methionine aminopeptidase
BD_RS02975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BD_RS02985	COG0494	nUDIX hydrolase
BD_RS02995	COG1272	protein, Hemolysin III
BD_RS03025	COG0840	transmembrane signaling receptor activity
BD_RS03090	COG0484	heat shock protein binding
BD_RS03130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BD_RS03165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BD_RS03165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BD_RS03170	COG2814	Major facilitator Superfamily
BD_RS03205	COG0312	modulator of DNA gyrase
BD_RS03210	COG0312	modulator of DNA gyrase
BD_RS03220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BD_RS03255	COG1136	(ABC) transporter
BD_RS03255	COG0577	efflux transmembrane transporter activity
BD_RS03265	COG0776	regulation of translation
BD_RS03280	COG0494	nUDIX hydrolase
BD_RS03285	COG0167	dihydroorotate dehydrogenase activity
BD_RS03290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BD_RS03305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BD_RS03305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BD_RS03315	COG1047	Peptidyl-prolyl cis-trans
BD_RS03365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BD_RS03400	COG0166	Belongs to the GPI family
BD_RS03475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BD_RS03495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BD_RS03515	COG0321	lipoyl(octanoyl) transferase activity
BD_RS03530	COG2365	Tyrosine phosphatase family
BD_RS03570	COG1489	DNA binding
BD_RS03600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BD_RS03600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BD_RS03630	COG0148	phosphopyruvate hydratase activity
BD_RS03660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BD_RS03660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BD_RS03675	COG2204	response regulator
BD_RS03680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BD_RS03685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BD_RS03690	COG0504	CTP synthase activity
BD_RS03695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BD_RS03695	COG0517	IMP dehydrogenase activity
BD_RS03705	COG3708	Transcriptional regulator
BD_RS03710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BD_RS03765	COG1126	abc transporter atp-binding protein
BD_RS03770	COG0765	amino acid transport
BD_RS03785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BD_RS03825	COG0811	peptide transport
BD_RS03850	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BD_RS03860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BD_RS03885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BD_RS03890	COG0481	GTPase activity
BD_RS03895	COG0681	Belongs to the peptidase S26 family
BD_RS03905	COG0681	Belongs to the peptidase S26 family
BD_RS03910	COG0540	Belongs to the ATCase OTCase family
BD_RS03915	COG0505	Belongs to the CarA family
BD_RS03925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BD_RS03935	COG1131	(ABC) transporter
BD_RS03945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BD_RS03985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BD_RS04025	COG2267	carboxylic ester hydrolase activity
BD_RS04050	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BD_RS04060	COG1595	DNA-templated transcription, initiation
BD_RS04070	COG2885	chlorophyll binding
BD_RS04070	COG3047	cAMP biosynthetic process
BD_RS04100	COG2154	pterin-4-alpha-carbinolamine dehydratase
BD_RS04140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BD_RS04145	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BD_RS04150	COG1064	alcohol dehydrogenase
BD_RS04160	COG0583	DNA-binding transcription factor activity
BD_RS04165	COG0583	DNA-binding transcription factor activity
BD_RS04200	COG0596	Alpha beta hydrolase
BD_RS04230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BD_RS04235	COG0071	Belongs to the small heat shock protein (HSP20) family
BD_RS04250	COG0517	IMP dehydrogenase activity
BD_RS04260	COG0826	peptidase U32
BD_RS04270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BD_RS04280	COG0039	L-malate dehydrogenase activity
BD_RS04290	COG0693	protein deglycase activity
BD_RS04300	COG0840	transmembrane signaling receptor activity
BD_RS04310	COG2356	endonuclease I
BD_RS04340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BD_RS04345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BD_RS04350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BD_RS04360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BD_RS04370	COG0644	oxidoreductase
BD_RS04370	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BD_RS04395	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD_RS04405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BD_RS04425	COG0312	modulator of DNA gyrase
BD_RS04430	COG0312	modulator of DNA gyrase
BD_RS04450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BD_RS04460	COG0793	Belongs to the peptidase S41A family
BD_RS04505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BD_RS04510	COG1324	tolerance protein
BD_RS04515	COG1253	flavin adenine dinucleotide binding
BD_RS04540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BD_RS04545	COG0514	ATP-dependent DNA helicase (RecQ)
BD_RS04555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BD_RS04575	COG3591	Belongs to the peptidase S1B family
BD_RS04580	COG0488	(ABC) transporter
BD_RS04625	COG3384	dioxygenase
BD_RS04635	COG0583	DNA-binding transcription factor activity
BD_RS04645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BD_RS04650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BD_RS04655	COG2062	phosphohistidine phosphatase, SixA
BD_RS04670	COG0248	Ppx GppA phosphatase
BD_RS04680	COG0704	Plays a role in the regulation of phosphate uptake
BD_RS04685	COG0745	RESPONSE REGULATOR receiver
BD_RS04690	COG5002	protein histidine kinase activity
BD_RS04740	COG4106	trans-aconitate 2-methyltransferase activity
BD_RS04745	COG0598	Magnesium transport protein CorA
BD_RS04750	COG1073	alpha beta
BD_RS04785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BD_RS04790	COG0470	DNA polymerase III
BD_RS04795	COG0084	hydrolase, TatD family'
BD_RS04830	COG0126	phosphoglycerate kinase activity
BD_RS04835	COG0149	triose-phosphate isomerase activity
BD_RS04850	COG0017	Asparaginyl-tRNA synthetase
BD_RS04855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BD_RS04865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BD_RS04880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BD_RS04885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BD_RS04910	COG0616	signal peptide processing
BD_RS04940	COG1840	ABC-type Fe3 transport system, periplasmic component
BD_RS04950	COG1580	Controls the rotational direction of flagella during chemotaxis
BD_RS04955	COG0612	Peptidase, M16
BD_RS04970	COG0583	DNA-binding transcription factor activity
BD_RS04975	COG0840	transmembrane signaling receptor activity
BD_RS05020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BD_RS05035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BD_RS05040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BD_RS05050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BD_RS05050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BD_RS05070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BD_RS05080	COG0124	histidyl-tRNA synthetase
BD_RS05095	COG4181	ATPase activity
BD_RS05165	COG0741	lytic transglycosylase activity
BD_RS05165	COG1388	LysM domain
BD_RS05175	COG0583	DNA-binding transcription factor activity
BD_RS05195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BD_RS05200	COG0489	protein tyrosine kinase activity
BD_RS05230	COG2832	Protein of unknown function (DUF454)
BD_RS05245	COG0423	glycine-tRNA ligase activity
BD_RS05260	COG0574	Belongs to the PEP-utilizing enzyme family
BD_RS05260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BD_RS05265	COG3008	intermembrane lipid transfer
BD_RS05270	COG2995	paraquat-inducible protein a
BD_RS05275	COG0753	catalase activity
BD_RS05290	COG1196	nuclear chromosome segregation
BD_RS05310	COG0778	Nitroreductase
BD_RS05315	COG1959	2 iron, 2 sulfur cluster binding
BD_RS05365	COG0702	epimerase
BD_RS05405	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BD_RS05410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BD_RS05415	COG1418	mRNA catabolic process
BD_RS05420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BD_RS05430	COG0596	Alpha beta hydrolase
BD_RS05435	COG0316	Belongs to the HesB IscA family
BD_RS05440	COG1104	cysteine desulfurase activity
BD_RS05450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD_RS05455	COG0539	negative regulation of cytoplasmic translation
BD_RS05465	COG1546	Belongs to the CinA family
BD_RS05465	COG1058	Belongs to the CinA family
BD_RS05475	COG1960	acyl-CoA dehydrogenase activity
BD_RS05485	COG5599	Phosphatase
BD_RS05495	COG0116	Belongs to the methyltransferase superfamily
BD_RS05495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BD_RS05500	COG1704	LemA family
BD_RS05505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BD_RS05530	COG1671	Belongs to the UPF0178 family
BD_RS05570	COG1940	carbohydrate kinase activity
BD_RS05580	COG3842	ATPase activity
BD_RS05585	COG3833	ABC-type maltose transport systems, permease component
BD_RS05590	COG1175	transmembrane transport
BD_RS05600	COG4580	involved in the transport of maltose and maltodextrins
BD_RS05610	COG1741	Belongs to the pirin family
BD_RS05615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BD_RS05630	COG0783	Belongs to the Dps family
BD_RS05685	COG1012	belongs to the aldehyde dehydrogenase family
BD_RS05690	COG0179	Fumarylacetoacetate (FAA) hydrolase
BD_RS05700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BD_RS05705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BD_RS05710	COG5002	protein histidine kinase activity
BD_RS05735	COG0473	3-isopropylmalate dehydrogenase activity
BD_RS05800	COG1193	negative regulation of DNA recombination
BD_RS05805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BD_RS05825	COG1404	Belongs to the peptidase S8 family
BD_RS05850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BD_RS05855	COG4968	Prepilin-type N-terminal cleavage methylation domain
BD_RS05880	COG0484	heat shock protein binding
BD_RS05885	COG0443	Heat shock 70 kDa protein
BD_RS05890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD_RS05905	COG2391	methyltransferase activity
BD_RS05920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BD_RS05955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BD_RS05965	COG3012	SEC-C Motif Domain Protein
BD_RS05970	COG4221	oxidoreductase activity
BD_RS06000	COG0564	pseudouridine synthase activity
BD_RS06025	COG0271	Belongs to the BolA IbaG family
BD_RS06040	COG0488	(ABC) transporter
BD_RS06055	COG0784	Response regulator, receiver
BD_RS06055	COG2205	protein histidine kinase activity
BD_RS06070	COG0024	Methionine aminopeptidase
BD_RS06075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BD_RS06080	COG0840	transmembrane signaling receptor activity
BD_RS06090	COG4335	DNA alkylation repair
BD_RS06100	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BD_RS06105	COG0745	RESPONSE REGULATOR receiver
BD_RS06140	COG4221	oxidoreductase activity
BD_RS06200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BD_RS06200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BD_RS06230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BD_RS06235	COG0006	proline dipeptidase activity
BD_RS06280	COG2205	protein histidine kinase activity
BD_RS06280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD_RS06285	COG0564	pseudouridine synthase activity
BD_RS06335	COG0513	Belongs to the DEAD box helicase family
BD_RS06340	COG2996	Protein conserved in bacteria
BD_RS06345	COG0724	RNA recognition motif
BD_RS06365	COG2032	superoxide dismutase activity
BD_RS06415	COG0513	Belongs to the DEAD box helicase family
BD_RS06425	COG0488	(ABC) transporter
BD_RS06445	COG3842	ATPase activity
BD_RS06455	COG1177	transmembrane transport
BD_RS06460	COG2270	Major facilitator Superfamily
BD_RS06465	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BD_RS06475	COG1846	Transcriptional regulator
BD_RS06480	COG1418	mRNA catabolic process
BD_RS06505	COG1404	Belongs to the peptidase S8 family
BD_RS06520	COG1764	response to oxidative stress
BD_RS06525	COG2855	membrane
BD_RS06555	COG1404	Belongs to the peptidase S8 family
BD_RS06585	COG0583	DNA-binding transcription factor activity
BD_RS06600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BD_RS06630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BD_RS06635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BD_RS06640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BD_RS06660	COG0268	Binds directly to 16S ribosomal RNA
BD_RS06665	COG0728	peptidoglycan biosynthetic process
BD_RS06670	COG0840	transmembrane signaling receptor activity
BD_RS06675	COG0840	transmembrane signaling receptor activity
BD_RS06720	COG0811	peptide transport
BD_RS06735	COG3956	TIGRFAM MazG family protein
BD_RS06745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BD_RS06755	COG1136	(ABC) transporter
BD_RS06755	COG0577	efflux transmembrane transporter activity
BD_RS06760	COG1136	(ABC) transporter
BD_RS06775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD_RS06785	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD_RS06790	COG1663	tetraacyldisaccharide 4'-kinase activity
BD_RS06795	COG1560	Kdo2-lipid A biosynthetic process
BD_RS06820	COG2204	response regulator
BD_RS06825	COG2205	protein histidine kinase activity
BD_RS06830	COG0196	riboflavin kinase activity
BD_RS06840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BD_RS06850	COG1459	type II secretion system
BD_RS06855	COG3852	Histidine kinase
BD_RS06860	COG2204	response regulator
BD_RS06875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BD_RS06890	COG0564	pseudouridine synthase activity
BD_RS06905	COG2204	response regulator
BD_RS06935	COG1132	(ABC) transporter
BD_RS06940	COG0572	uridine kinase
BD_RS06945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BD_RS06960	COG1012	belongs to the aldehyde dehydrogenase family
BD_RS06965	COG2198	Histidine kinase
BD_RS06965	COG0784	Response regulator, receiver
BD_RS06965	COG2205	protein histidine kinase activity
BD_RS06965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD_RS07020	COG0779	Required for maturation of 30S ribosomal subunits
BD_RS07025	COG0195	Participates in both transcription termination and antitermination
BD_RS07030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BD_RS07035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BD_RS07040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BD_RS07045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BD_RS07050	COG1185	polyribonucleotide nucleotidyltransferase activity
BD_RS07055	COG0612	Peptidase, M16
BD_RS07060	COG0756	dUTP diphosphatase activity
BD_RS07095	COG1216	Glycosyl transferase, family 2
BD_RS07110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BD_RS07115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BD_RS07120	COG1561	YicC-like family, N-terminal region
BD_RS07125	COG0194	GDP metabolic process
BD_RS07130	COG1758	RNA polymerase activity
BD_RS07140	COG4191	Histidine kinase
BD_RS07140	COG0784	Response regulator, receiver
BD_RS07165	COG4264	IucA IucC family
BD_RS07260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BD_RS07290	COG2096	Adenosyltransferase
BD_RS07300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BD_RS07300	COG1333	cytochrome c biogenesis protein
BD_RS07305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BD_RS07305	COG1333	cytochrome c biogenesis protein
BD_RS07360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BD_RS07365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BD_RS07370	COG1490	D-aminoacyl-tRNA deacylase activity
BD_RS07375	COG0427	acetyl-CoA hydrolase
BD_RS07390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BD_RS07395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BD_RS07400	COG1304	FMN binding
BD_RS07430	COG0357	Ribosomal RNA small subunit methyltransferase G
BD_RS07430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BD_RS07445	COG0357	Ribosomal RNA small subunit methyltransferase G
BD_RS07450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BD_RS07455	COG0072	phenylalanine-tRNA ligase activity
BD_RS07455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BD_RS07460	COG0776	regulation of translation
BD_RS07500	COG0628	permease
BD_RS07530	COG0735	belongs to the Fur family
BD_RS07540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BD_RS07545	COG0573	inorganic phosphate transmembrane transporter activity
BD_RS07550	COG0581	inorganic phosphate transmembrane transporter activity
BD_RS07555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BD_RS07610	COG1368	sulfuric ester hydrolase activity
BD_RS07620	COG1368	sulfuric ester hydrolase activity
BD_RS07640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BD_RS07645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BD_RS07650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BD_RS07655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BD_RS07660	COG2089	acid synthase
BD_RS07670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BD_RS07675	COG1083	cytidylyl-transferase
BD_RS07700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BD_RS07710	COG1086	Polysaccharide biosynthesis protein
BD_RS07730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BD_RS07735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BD_RS07765	COG2070	2-Nitropropane dioxygenase
BD_RS07785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BD_RS07795	COG3021	interspecies interaction between organisms
BD_RS07815	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BD_RS07830	COG3932	Exopolysaccharide synthesis, ExoD
BD_RS07875	COG0842	Transport permease protein
BD_RS07880	COG1131	(ABC) transporter
BD_RS07895	COG1720	tRNA m6t6A37 methyltransferase activity
BD_RS07905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BD_RS07905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BD_RS07920	COG1077	Cell shape determining protein MreB Mrl
BD_RS07955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BD_RS07960	COG0583	DNA-binding transcription factor activity
BD_RS08005	COG2076	Multidrug Resistance protein
BD_RS08010	COG0431	NADPH-dependent FMN reductase
BD_RS08020	COG2205	protein histidine kinase activity
BD_RS08025	COG0745	RESPONSE REGULATOR receiver
BD_RS08060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BD_RS08065	COG2884	Cell division ATP-binding protein ftsE
BD_RS08090	COG2171	N-acyltransferase activity
BD_RS08100	COG0019	diaminopimelate decarboxylase activity
BD_RS08105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BD_RS08110	COG0516	GMP reductase activity
BD_RS08110	COG0517	IMP dehydrogenase activity
BD_RS08205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BD_RS08220	COG0318	PFAM AMP-dependent synthetase and ligase
BD_RS08230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BD_RS08235	COG0326	Molecular chaperone. Has ATPase activity
BD_RS08240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BD_RS08250	COG3483	tryptophan 2,3-dioxygenase activity
BD_RS08280	COG0038	chloride channel
BD_RS08300	COG0617	tRNA 3'-terminal CCA addition
BD_RS08325	COG2197	response regulator
BD_RS08335	COG2205	protein histidine kinase activity
BD_RS08335	COG0784	Response regulator, receiver
BD_RS08350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BD_RS08370	COG1024	Enoyl-CoA hydratase
BD_RS08370	COG1250	3-hydroxyacyl-CoA dehydrogenase
BD_RS08390	COG3104	oligopeptide transport
BD_RS08425	COG1250	3-hydroxyacyl-CoA dehydrogenase
BD_RS08430	COG1024	Enoyl-CoA hydratase
BD_RS08435	COG1703	isobutyryl-CoA mutase activity
BD_RS08435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BD_RS08435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BD_RS08440	COG2205	protein histidine kinase activity
BD_RS08445	COG2261	transglycosylase associated protein
BD_RS08455	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BD_RS08460	COG0688	phosphatidylethanolamine metabolic process
BD_RS08470	COG0720	synthase
BD_RS08500	COG1088	dTDP-glucose 4,6-dehydratase activity
BD_RS08505	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BD_RS08510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BD_RS08525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD_RS08530	COG1131	(ABC) transporter
BD_RS08535	COG1131	(ABC) transporter
BD_RS08540	COG0842	Transport permease protein
BD_RS08545	COG0842	Transport permease protein
BD_RS08580	COG0471	metal ion transport
BD_RS08700	COG0531	amino acid
BD_RS08715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BD_RS08720	COG0824	Thioesterase
BD_RS08760	COG1012	belongs to the aldehyde dehydrogenase family
BD_RS08765	COG0037	tRNA processing
BD_RS08770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BD_RS08775	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BD_RS08785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BD_RS08790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BD_RS08795	COG0802	atpase or kinase
BD_RS08825	COG0482	sulfurtransferase activity
BD_RS08830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BD_RS08835	COG0571	ribonuclease III activity
BD_RS08840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BD_RS08845	COG1160	GTP binding
BD_RS08850	COG0733	neurotransmitter:sodium symporter activity
BD_RS08860	COG0386	Belongs to the glutathione peroxidase family
BD_RS08870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BD_RS08880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BD_RS08885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BD_RS08895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BD_RS08930	COG2166	iron-sulfur cluster assembly
BD_RS08945	COG0217	transcriptional regulatory protein
BD_RS08960	COG1187	pseudouridine synthase activity
BD_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
BD_RS08980	COG5001	Diguanylate cyclase
BD_RS08980	COG1716	ATPase activity
BD_RS08985	COG4166	transmembrane transport
BD_RS08990	COG1960	acyl-CoA dehydrogenase activity
BD_RS08995	COG1994	Peptidase M50
BD_RS09000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BD_RS09005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BD_RS09035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD_RS09040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD_RS09040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BD_RS09045	COG1242	4 iron, 4 sulfur cluster binding
BD_RS09105	COG3158	transport of potassium into the cell
BD_RS09120	COG3781	membrane
BD_RS09145	COG4942	peptidase
BD_RS09150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BD_RS09155	COG0698	ribose 5-phosphate isomerase
BD_RS09160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BD_RS09165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BD_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
BD_RS09180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BD_RS09185	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BD_RS09215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BD_RS09220	COG1116	anion transmembrane transporter activity
BD_RS09235	COG4974	Belongs to the 'phage' integrase family
BD_RS09245	COG0018	arginyl-trna synthetase
BD_RS09275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BD_RS09285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BD_RS09300	COG1011	Hydrolase
BD_RS09320	COG1686	Belongs to the peptidase S11 family
BD_RS09345	COG1837	Belongs to the UPF0109 family
BD_RS09365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BD_RS09380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BD_RS09420	COG0037	tRNA processing
BD_RS09430	COG0625	glutathione transferase activity
BD_RS09470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BD_RS09500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BD_RS09500	COG0519	Catalyzes the synthesis of GMP from XMP
BD_RS09505	COG0517	IMP dehydrogenase activity
BD_RS09505	COG0516	GMP reductase activity
BD_RS09510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BD_RS09520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BD_RS09520	COG4651	solute:proton antiporter activity
BD_RS09530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BD_RS09565	COG0183	Belongs to the thiolase family
BD_RS09570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BD_RS09580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD_RS09580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BD_RS09610	COG0776	regulation of translation
BD_RS09625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BD_RS09645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BD_RS09660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BD_RS09665	COG0335	large ribosomal subunit rRNA binding
BD_RS09670	COG0336	Belongs to the RNA methyltransferase TrmD family
BD_RS09670	COG4752	Belongs to the RNA methyltransferase TrmD family
BD_RS09675	COG0336	Belongs to the RNA methyltransferase TrmD family
BD_RS09680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BD_RS09690	COG0228	four-way junction DNA binding
BD_RS09695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BD_RS09715	COG0842	Transport permease protein
BD_RS09720	COG1131	(ABC) transporter
BD_RS09725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BD_RS09730	COG1054	Belongs to the UPF0176 family
BD_RS09755	COG0387	Pfam Sodium calcium exchanger
BD_RS09760	COG2900	Belongs to the SlyX family
BD_RS09770	COG0328	RNA-DNA hybrid ribonuclease activity
BD_RS09775	COG2197	response regulator
BD_RS09780	COG2176	DNA-directed DNA polymerase activity
BD_RS09795	COG0745	RESPONSE REGULATOR receiver
BD_RS09800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BD_RS09805	COG0471	metal ion transport
BD_RS09805	COG3273	potassium ion transport
BD_RS09820	COG0778	Nitroreductase
BD_RS09845	COG2197	response regulator
BD_RS09880	COG0730	response to heat
BD_RS09890	COG2814	Major facilitator Superfamily
BD_RS09905	COG1418	mRNA catabolic process
BD_RS09910	COG2205	protein histidine kinase activity
BD_RS09910	COG0784	Response regulator, receiver
BD_RS09920	COG1253	flavin adenine dinucleotide binding
BD_RS09935	COG0038	chloride channel
BD_RS09940	COG1960	acyl-CoA dehydrogenase activity
BD_RS09950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BD_RS09985	COG2205	protein histidine kinase activity
BD_RS10000	COG0616	signal peptide processing
BD_RS10005	COG0444	Belongs to the ABC transporter superfamily
BD_RS10010	COG4608	Belongs to the ABC transporter superfamily
BD_RS10015	COG4166	transmembrane transport
BD_RS10020	COG0601	transmembrane transport
BD_RS10025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BD_RS10040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BD_RS10060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BD_RS10075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BD_RS10080	COG1090	epimerase
BD_RS10085	COG0415	Belongs to the DNA photolyase family
BD_RS10090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BD_RS10095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BD_RS10125	COG1612	heme a metabolic process
BD_RS10125	COG0109	protoheme IX farnesyltransferase activity
BD_RS10140	COG0494	nUDIX hydrolase
BD_RS10160	COG2217	Heavy metal translocating P-type atpase
BD_RS10165	COG1937	Protein conserved in bacteria
BD_RS10195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BD_RS10205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BD_RS10210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BD_RS10215	COG1862	Preprotein translocase
BD_RS10220	COG0343	queuine tRNA-ribosyltransferase activity
BD_RS10225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BD_RS10240	COG0069	glutamate synthase activity
BD_RS10265	COG1295	ribonuclease BN
BD_RS10270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BD_RS10270	COG0723	plastoquinol--plastocyanin reductase activity
BD_RS10310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BD_RS10315	COG1720	tRNA m6t6A37 methyltransferase activity
BD_RS10320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BD_RS10330	COG0288	reversible hydration of carbon dioxide
BD_RS10350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BD_RS10370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BD_RS10370	COG4651	solute:proton antiporter activity
BD_RS10380	COG0463	Glycosyl transferase, family 2
BD_RS10420	COG0366	Alpha amylase catalytic
BD_RS10435	COG1863	multisubunit Na H antiporter MnhE subunit
BD_RS10440	COG0651	ATP synthesis coupled electron transport
BD_RS10445	COG1006	Multisubunit Na H antiporter MnhC subunit
BD_RS10450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BD_RS10450	COG2111	Na H antiporter
BD_RS10460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BD_RS10490	COG2217	Heavy metal translocating P-type atpase
BD_RS10520	COG4974	Belongs to the 'phage' integrase family
BD_RS10535	COG2385	sporulation resulting in formation of a cellular spore
BD_RS10570	COG0728	peptidoglycan biosynthetic process
BD_RS10575	COG0322	excinuclease ABC activity
BD_RS10580	COG0556	nucleotide-excision repair
BD_RS10600	COG0215	cysteine-tRNA ligase activity
BD_RS10605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BD_RS10615	COG1404	Belongs to the peptidase S8 family
BD_RS10630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BD_RS10650	COG0826	peptidase U32
BD_RS10660	COG1192	Involved in chromosome partitioning
BD_RS10675	COG3591	Belongs to the peptidase S1B family
BD_RS10680	COG0784	Response regulator, receiver
BD_RS10680	COG2205	protein histidine kinase activity
BD_RS10695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BD_RS10700	COG1830	Aldolase
BD_RS10710	COG0534	Mate efflux family protein
BD_RS10720	COG0477	Major facilitator Superfamily
BD_RS10735	COG0633	Ferredoxin
BD_RS10735	COG3217	Mosc domain protein beta barrel domain protein
BD_RS10750	COG2226	methyltransferase
BD_RS10765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BD_RS10770	COG0084	hydrolase, TatD family'
BD_RS10780	COG0586	Pfam SNARE associated Golgi protein
BD_RS10805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BD_RS10805	COG0116	Belongs to the methyltransferase superfamily
BD_RS10825	COG0859	PFAM glycosyl transferase family 9
BD_RS10885	COG0038	chloride channel
BD_RS10940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BD_RS10995	COG0745	RESPONSE REGULATOR receiver
BD_RS11030	COG0745	RESPONSE REGULATOR receiver
BD_RS11040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BD_RS11045	COG0717	Belongs to the dCTP deaminase family
BD_RS11150	COG2871	sodium ion transport
BD_RS11155	COG0697	spore germination
BD_RS11175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BD_RS11190	COG1469	GTP cyclohydrolase I activity
BD_RS11195	COG0424	maF-like protein
BD_RS11200	COG0295	cytidine deaminase activity
BD_RS11230	COG1792	Involved in formation and maintenance of cell shape
BD_RS11240	COG0768	penicillin binding
BD_RS11245	COG0772	Belongs to the SEDS family
BD_RS11275	COG3118	belongs to the thioredoxin family
BD_RS11290	COG0758	DNA mediated transformation
BD_RS11290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BD_RS11320	COG0686	Belongs to the AlaDH PNT family
BD_RS11340	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BD_RS11355	COG2255	four-way junction helicase activity
BD_RS11360	COG0632	four-way junction helicase activity
BD_RS11365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BD_RS11375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BD_RS11390	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BD_RS11420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BD_RS11425	COG0840	transmembrane signaling receptor activity
BD_RS11430	COG0840	transmembrane signaling receptor activity
BD_RS11440	COG0095	Lipoate-protein ligase
BD_RS11485	COG0583	DNA-binding transcription factor activity
BD_RS11495	COG3634	alkyl hydroperoxide reductase activity
BD_RS11510	COG0308	aminopeptidase N
BD_RS11515	COG0302	gtp cyclohydrolase
BD_RS11575	COG3591	Belongs to the peptidase S1B family
BD_RS11605	COG1132	(ABC) transporter
BD_RS11610	COG1132	(ABC) transporter
BD_RS11615	COG2239	Acts as a magnesium transporter
BD_RS11660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BD_RS11670	COG2967	ApaG domain
BD_RS11725	COG0259	pyridoxamine-phosphate oxidase activity
BD_RS11730	COG0545	Peptidyl-prolyl cis-trans isomerase
BD_RS11735	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BD_RS11740	COG0709	Synthesizes selenophosphate from selenide and ATP
BD_RS11745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BD_RS11760	COG0745	RESPONSE REGULATOR receiver
BD_RS11765	COG5002	protein histidine kinase activity
BD_RS11795	COG1132	(ABC) transporter
BD_RS11800	COG3437	response regulator, receiver
BD_RS11800	COG2205	protein histidine kinase activity
BD_RS11800	COG3850	Histidine kinase
BD_RS11800	COG4999	Histidine kinase
BD_RS11830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD_RS11860	COG4548	von Willebrand factor, type A
BD_RS11865	COG0714	Associated with various cellular activities
BD_RS11875	COG2010	Cytochrome c
BD_RS11920	COG3278	Belongs to the heme-copper respiratory oxidase family
BD_RS11925	COG2010	Cytochrome c
BD_RS11930	COG0348	domain, Protein
BD_RS11950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BD_RS11960	COG0783	Belongs to the Dps family
BD_RS11970	COG0840	transmembrane signaling receptor activity
BD_RS11975	COG0786	glutamate:sodium symporter activity
BD_RS11995	COG3591	Belongs to the peptidase S1B family
BD_RS12020	COG2272	Belongs to the type-B carboxylesterase lipase family
BD_RS12030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BD_RS12035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BD_RS12035	COG3608	succinylglutamate desuccinylase aspartoacylase
BD_RS12040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BD_RS12050	COG2346	COG2346, Truncated hemoglobins
BD_RS12080	COG0572	uridine kinase
BD_RS12095	COG4772	TonB-dependent receptor
BD_RS12115	COG2824	Alkylphosphonate utilization operon protein PhnA
BD_RS12120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BD_RS12170	COG3214	Protein conserved in bacteria
BD_RS12180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BD_RS12290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BD_RS12305	COG1024	Enoyl-CoA hydratase
BD_RS12315	COG1968	undecaprenyl-diphosphatase activity
BD_RS12320	COG0668	transmembrane transport
BD_RS12340	COG0860	N-Acetylmuramoyl-L-alanine amidase
BD_RS12345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BD_RS12350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BD_RS12370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BD_RS12375	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BD_RS12380	COG0193	aminoacyl-tRNA hydrolase activity
BD_RS12385	COG0012	GTP binding
BD_RS12390	COG0154	amidase activity
BD_RS12395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BD_RS12400	COG0601	transmembrane transport
BD_RS12410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BD_RS12415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD_RS12435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BD_RS12455	COG1228	amidohydrolase
BD_RS12460	COG0071	Belongs to the small heat shock protein (HSP20) family
BD_RS12485	COG0588	phosphoglycerate mutase activity
BD_RS12490	COG0567	Dehydrogenase, E1 component
BD_RS12495	COG0508	dehydrogenase complex catalyzes the overall conversion of
BD_RS12570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BD_RS12580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BD_RS12595	COG0494	nUDIX hydrolase
BD_RS12600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BD_RS12605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BD_RS12610	COG0242	peptide deformylase activity
BD_RS12700	COG2072	flavoprotein involved in K transport
BD_RS12725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BD_RS12730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BD_RS12775	COG2304	oxidoreductase activity
BD_RS12795	COG0714	Associated with various cellular activities
BD_RS12800	COG0501	Belongs to the peptidase M48B family
BD_RS12810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BD_RS12815	COG2088	sporulation resulting in formation of a cellular spore
BD_RS12855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BD_RS12885	COG3264	Mechanosensitive ion channel
BD_RS12885	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BD_RS12905	COG0564	pseudouridine synthase activity
BD_RS12920	COG3005	denitrification pathway
BD_RS12925	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BD_RS12940	COG0835	chemotaxis
BD_RS12945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BD_RS12950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BD_RS12965	COG0784	Response regulator, receiver
BD_RS12965	COG2205	protein histidine kinase activity
BD_RS12970	COG0281	malic enzyme
BD_RS12980	COG2353	YceI-like domain
BD_RS12985	COG2197	response regulator
BD_RS12990	COG2205	protein histidine kinase activity
BD_RS13015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BD_RS13030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BD_RS13040	COG0784	Response regulator, receiver
BD_RS13040	COG2205	protein histidine kinase activity
BD_RS13060	COG1690	Belongs to the RtcB family
BD_RS13075	COG1027	Aspartate ammonia-lyase
BD_RS13095	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BD_RS13200	COG1368	sulfuric ester hydrolase activity
BD_RS13210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BD_RS13220	COG0277	FAD linked oxidase domain protein
BD_RS13230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BD_RS13250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BD_RS13255	COG1295	ribonuclease BN
BD_RS13275	COG2195	Cleaves the N-terminal amino acid of tripeptides
BD_RS13300	COG0583	DNA-binding transcription factor activity
BD_RS13305	COG0702	epimerase
BD_RS13335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BD_RS13370	COG2942	2-epimerase
BD_RS13380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BD_RS13380	COG0519	Catalyzes the synthesis of GMP from XMP
BD_RS13395	COG1960	acyl-CoA dehydrogenase activity
BD_RS13475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BD_RS13495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BD_RS13500	COG0203	ribosomal protein L17
BD_RS13505	COG0202	RNA polymerase activity
BD_RS13510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BD_RS13515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BD_RS13520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BD_RS13525	COG0563	adenylate kinase activity
BD_RS13530	COG0201	protein transport
BD_RS13535	COG0200	Binds to the 23S rRNA
BD_RS13540	COG1841	ribosomal large subunit assembly
BD_RS13545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BD_RS13550	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BD_RS13555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BD_RS13560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BD_RS13565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BD_RS13570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BD_RS13575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BD_RS13580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BD_RS13585	COG0255	Belongs to the universal ribosomal protein uL29 family
BD_RS13590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BD_RS13595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BD_RS13600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BD_RS13605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BD_RS13610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BD_RS13615	COG0089	rRNA binding
BD_RS13620	COG0088	Forms part of the polypeptide exit tunnel
BD_RS13625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BD_RS13630	COG0051	transcription antitermination factor activity, RNA binding
BD_RS13635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BD_RS13640	COG0049	tRNA binding
BD_RS13645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BD_RS13650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BD_RS13655	COG0085	RNA polymerase activity
BD_RS13665	COG0222	ribosome binding
BD_RS13670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BD_RS13675	COG0081	regulation of translation
BD_RS13680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BD_RS13685	COG0250	Participates in transcription elongation, termination and antitermination
BD_RS13700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BD_RS13730	COG0284	orotidine-5'-phosphate decarboxylase activity
BD_RS13755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BD_RS13760	COG0138	bifunctional purine biosynthesis protein purh
BD_RS13765	COG0047	phosphoribosylformylglycinamidine synthase activity
BD_RS13770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BD_RS13775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BD_RS13780	COG0151	Belongs to the GarS family
BD_RS13790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BD_RS13910	COG0442	prolyl-tRNA aminoacylation
BD_RS13915	COG2204	response regulator
BD_RS13920	COG5000	phosphorelay sensor kinase activity
BD_RS13925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BD_RS13930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BD_RS13930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BD_RS13935	COG0307	riboflavin synthase, alpha
BD_RS13965	COG1803	Methylglyoxal synthase
BD_RS13970	COG0542	response to heat
BD_RS13980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BD_RS14000	COG0745	RESPONSE REGULATOR receiver
BD_RS14005	COG1846	Transcriptional regulator
BD_RS14045	COG1381	Involved in DNA repair and RecF pathway recombination
BD_RS14095	COG0583	DNA-binding transcription factor activity
BD_RS14100	COG0861	Integral membrane protein TerC family
BD_RS14105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BD_RS14115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD_RS14120	COG1034	ATP synthesis coupled electron transport
BD_RS14130	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BD_RS14135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD_RS14135	COG0649	NAD binding
BD_RS14140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD_RS14165	COG0840	transmembrane signaling receptor activity
BD_RS14195	COG1132	(ABC) transporter
BD_RS14220	COG3639	organic phosphonate transmembrane transporter activity
BD_RS14225	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BD_RS14230	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BD_RS14245	COG1643	Atp-dependent helicase
BD_RS14260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BD_RS14270	COG1045	serine acetyltransferase
BD_RS14275	COG3481	metal-dependent phosphohydrolase, HD sub domain
BD_RS14290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BD_RS14295	COG1127	ABC transporter
BD_RS14300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BD_RS14305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BD_RS14315	COG3852	Histidine kinase
BD_RS14335	COG0300	oxidoreductase activity
BD_RS14340	COG0328	RNA-DNA hybrid ribonuclease activity
BD_RS14375	COG1074	ATP-dependent DNA helicase activity
BD_RS14415	COG0237	dephospho-CoA kinase activity
BD_RS14420	COG0515	serine threonine protein kinase
BD_RS14425	COG1022	Amp-dependent synthetase and ligase
BD_RS14445	COG3848	Pyruvate phosphate dikinase
BD_RS14445	COG0574	Belongs to the PEP-utilizing enzyme family
BD_RS14495	COG4591	ABC-type transport system involved in lipoprotein release permease component
BD_RS14500	COG0577	efflux transmembrane transporter activity
BD_RS14500	COG1136	(ABC) transporter
BD_RS14525	COG0339	signal peptide processing
BD_RS14530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BD_RS14535	COG0497	DNA recombination
BD_RS14555	COG0840	transmembrane signaling receptor activity
BD_RS14590	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BD_RS14605	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD_RS14610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BD_RS14620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BD_RS14625	COG0840	transmembrane signaling receptor activity
BD_RS14645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BD_RS14650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BD_RS14655	COG0772	Belongs to the SEDS family
BD_RS14665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BD_RS14670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BD_RS14680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BD_RS14685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BD_RS14710	COG0514	ATP-dependent DNA helicase (RecQ)
BD_RS14720	COG0768	penicillin binding
BD_RS14730	COG0275	rRNA processing
BD_RS14740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BD_RS14760	COG2119	membrane
BD_RS14780	COG1741	Belongs to the pirin family
BD_RS14785	COG0583	DNA-binding transcription factor activity
BD_RS14790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BD_RS14805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BD_RS14850	COG0739	heme binding
BD_RS14850	COG0741	lytic transglycosylase activity
BD_RS14850	COG1196	nuclear chromosome segregation
BD_RS14855	COG2027	D-alanyl-D-alanine carboxypeptidase
BD_RS14860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BD_RS14875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BD_RS14885	COG2176	DNA-directed DNA polymerase activity
BD_RS14895	COG1360	Flagellar Motor Protein
BD_RS14900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BD_RS14910	COG0840	transmembrane signaling receptor activity
BD_RS14940	COG1187	pseudouridine synthase activity
BD_RS14970	COG2264	protein methyltransferase activity
BD_RS14975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BD_RS14985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BD_RS14985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BD_RS15005	COG0726	polysaccharide deacetylase
BD_RS15040	COG0443	Heat shock 70 kDa protein
BD_RS15050	COG3384	dioxygenase
BD_RS15055	COG0400	carboxylic ester hydrolase activity
BD_RS15060	COG2814	Major facilitator Superfamily
BD_RS15085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BD_RS15130	COG2204	response regulator
BD_RS15135	COG4964	Belongs to the GSP D family
BD_RS15160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BD_RS15170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BD_RS15185	COG1191	sigma factor activity
BD_RS15195	COG1419	protein localization to endoplasmic reticulum
BD_RS15200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BD_RS15205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BD_RS15210	COG1684	flagellar biosynthetic protein fliR
BD_RS15215	COG1987	bacterial-type flagellum assembly
BD_RS15220	COG1338	Plays a role in the flagellum-specific transport system
BD_RS15245	COG3237	CsbD-like
BD_RS15265	COG0483	inositol monophosphate 1-phosphatase activity
BD_RS15285	COG0210	DNA helicase
BD_RS15295	COG0840	transmembrane signaling receptor activity
BD_RS15300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BD_RS15305	COG1509	lysine 2,3-aminomutase activity
BD_RS15335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BD_RS15370	COG5002	protein histidine kinase activity
BD_RS15390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BD_RS15395	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BD_RS15400	COG4191	Histidine kinase
BD_RS15420	COG0803	Belongs to the bacterial solute-binding protein 9 family
BD_RS15425	COG1121	(ABC) transporter
BD_RS15460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BD_RS15470	COG0205	6-phosphofructokinase activity
BD_RS15480	COG0559	Belongs to the binding-protein-dependent transport system permease family
BD_RS15520	COG0745	RESPONSE REGULATOR receiver
BD_RS15535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BD_RS15555	COG1157	protein secretion by the type III secretion system
BD_RS15565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BD_RS15570	COG1766	The M ring may be actively involved in energy transduction
BD_RS15575	COG1677	Flagellar hook-basal body complex protein FliE
BD_RS15585	COG1815	bacterial-type flagellum-dependent cell motility
BD_RS15590	COG2204	response regulator
BD_RS15605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BD_RS15610	COG1127	ABC transporter
BD_RS15645	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BD_RS15650	COG1435	thymidine kinase activity
BD_RS15655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BD_RS15670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BD_RS15675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BD_RS15680	COG2866	Carboxypeptidase
BD_RS15690	COG4191	Histidine kinase
BD_RS15690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD_RS15695	COG2205	protein histidine kinase activity
BD_RS15695	COG0784	Response regulator, receiver
BD_RS15700	COG0745	RESPONSE REGULATOR receiver
BD_RS15705	COG2204	response regulator
BD_RS15760	COG0113	porphobilinogen synthase activity
BD_RS15770	COG0181	hydroxymethylbilane synthase activity
BD_RS15775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BD_RS15785	COG0745	RESPONSE REGULATOR receiver
BD_RS15790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BD_RS15795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BD_RS15805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BD_RS15810	COG1346	cytolysis
BD_RS15815	COG1380	Effector of murein hydrolase LrgA
BD_RS15830	COG0513	Belongs to the DEAD box helicase family
BD_RS15835	COG2945	thiolester hydrolase activity
BD_RS15835	COG0596	Alpha beta hydrolase
BD_RS15840	COG0617	tRNA 3'-terminal CCA addition
BD_RS15850	COG1505	serine-type exopeptidase activity
BD_RS15855	COG2201	protein-glutamate methylesterase activity
BD_RS15860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BD_RS15865	COG2198	Histidine kinase
BD_RS15865	COG0643	Histidine kinase
BD_RS15870	COG0835	chemotaxis
BD_RS15895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BD_RS15905	COG0405	Gamma-glutamyltransferase
BD_RS15925	COG0596	Alpha beta hydrolase
BD_RS15930	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BD_RS15940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BD_RS15940	COG1605	Chorismate mutase
BD_RS15945	COG2226	methyltransferase
BD_RS15950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BD_RS15965	COG2204	response regulator
BD_RS15980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BD_RS15985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BD_RS15990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BD_RS15995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BD_RS16000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BD_RS16015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BD_RS16025	COG0667	Aldo Keto reductase
BD_RS16030	COG1408	metallophosphoesterase
BD_RS16075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BD_RS16085	COG1741	Belongs to the pirin family
BD_RS16095	COG1956	GAF domain-containing protein
BD_RS16115	COG1309	transcriptional regulator
BD_RS16130	COG0708	Exodeoxyribonuclease III
BD_RS16135	COG0450	alkyl hydroperoxide reductase
BD_RS16145	COG0745	RESPONSE REGULATOR receiver
BD_RS16150	COG2198	Histidine kinase
BD_RS16150	COG2205	protein histidine kinase activity
BD_RS16150	COG0784	Response regulator, receiver
BD_RS16180	COG0793	Belongs to the peptidase S41A family
BD_RS16185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BD_RS16190	COG3186	Phenylalanine-4-hydroxylase
BD_RS16235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BD_RS16250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BD_RS16275	COG1028	Short-chain dehydrogenase reductase Sdr
BD_RS16295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BD_RS16300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BD_RS16310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BD_RS16315	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BD_RS16320	COG0488	(ABC) transporter
BD_RS16335	COG0488	(ABC) transporter
BD_RS16375	COG0439	Biotin carboxylase
BD_RS16380	COG1024	Enoyl-CoA hydratase
BD_RS16385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BD_RS16420	COG4555	ABC transporter
BD_RS16435	COG0625	glutathione transferase activity
BD_RS16520	COG0784	Response regulator, receiver
BD_RS16520	COG5002	protein histidine kinase activity
BD_RS16535	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BD_RS16565	COG0583	DNA-binding transcription factor activity
BD_RS16570	COG2234	aminopeptidase activity
BD_RS16585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BD_RS16610	COG0071	Belongs to the small heat shock protein (HSP20) family
BD_RS16645	COG0488	(ABC) transporter
BD_RS16680	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BD_RS16690	COG5002	protein histidine kinase activity
BD_RS16695	COG0784	Response regulator, receiver
BD_RS16700	COG2205	protein histidine kinase activity
BD_RS16700	COG0784	Response regulator, receiver
BD_RS16700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD_RS16700	COG2198	Histidine kinase
BD_RS16715	COG5507	3-demethylubiquinone-9 3-methyltransferase
BD_RS16730	COG2814	Major facilitator Superfamily
BD_RS16785	COG0708	Exodeoxyribonuclease III
BD_RS16820	COG0693	protein deglycase activity
BD_RS16825	COG2205	protein histidine kinase activity
BD_RS16825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD_RS16835	COG1061	Type III restriction enzyme res subunit
BD_RS16840	COG2850	peptidyl-arginine hydroxylation
BD_RS16845	COG1733	regulation of RNA biosynthetic process
BD_RS16850	COG1741	Belongs to the pirin family
BD_RS16855	COG1942	4-Oxalocrotonate Tautomerase
BD_RS16870	COG0583	DNA-binding transcription factor activity
BD_RS16900	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BD_RS16950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BD_RS16990	COG2249	NAD(P)H dehydrogenase (quinone) activity
BD_RS17020	COG0538	isocitrate dehydrogenase activity
BD_RS17055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BD_RS17060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BD_RS17065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BD_RS17070	COG1100	Small GTP-binding protein
BD_RS17075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BD_RS17125	COG3089	Belongs to the UPF0270 family
BD_RS17150	COG3852	Histidine kinase
BD_RS17155	COG2205	protein histidine kinase activity
BD_RS17155	COG0784	Response regulator, receiver
BD_RS17165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BD_RS17170	COG0740	serine-type endopeptidase activity
BD_RS17175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BD_RS17210	COG0003	Pfam Anion-transporting ATPase
BD_RS17220	COG0544	peptidyl-prolyl cis-trans isomerase activity
BD_RS17255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BD_RS17265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BD_RS17285	COG0052	Belongs to the universal ribosomal protein uS2 family
BD_RS17290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BD_RS17295	COG0528	UMP kinase activity
BD_RS17300	COG0233	cytoplasmic translational termination
BD_RS17305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BD_RS17310	COG4589	Belongs to the CDS family
BD_RS17315	COG0750	zinc metalloprotease
BD_RS17320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BD_RS17325	COG2894	cell division
BD_RS17335	COG0564	pseudouridine synthase activity
BD_RS17340	COG1496	oxidoreductase activity
BD_RS17345	COG2094	Belongs to the DNA glycosylase MPG family
BD_RS17350	COG1272	protein, Hemolysin III
BD_RS17360	COG0626	cystathionine gamma-synthase activity
BD_RS17400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BD_RS17405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BD_RS17415	COG1127	ABC transporter
BD_RS17420	COG1127	ABC transporter
BD_RS17425	COG0045	succinate-CoA ligase (ADP-forming) activity
BD_RS17430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BD_RS17455	COG1136	(ABC) transporter
BD_RS17510	COG0105	UTP biosynthetic process
BD_RS17515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BD_RS17525	COG1426	Protein conserved in bacteria
BD_RS17540	COG0633	Ferredoxin
BD_RS17545	COG2176	DNA-directed DNA polymerase activity
BD_RS17555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BD_RS17555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BD_RS17575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BD_RS17595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BD_RS17605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BD_RS17610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BD_RS17615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BD_RS17640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BD_RS17655	COG1404	Belongs to the peptidase S8 family
BD_RS17660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BD_RS17665	COG0439	Biotin carboxylase
BD_RS17680	COG0805	protein transport
BD_RS17700	COG0612	Peptidase, M16
BD_RS17705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BD_RS17710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BD_RS17715	COG0484	heat shock protein binding
BD_RS17735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BD_RS17775	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BD_RS17780	COG0714	Associated with various cellular activities
BD_RS17785	COG1007	ATP synthesis coupled electron transport
BD_RS17800	COG0713	ATP synthesis coupled electron transport
BD_RS17805	COG0839	Belongs to the complex I subunit 6 family
BD_RS17810	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BD_RS17815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD_RS17830	COG1472	Belongs to the glycosyl hydrolase 3 family
BD_RS17835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BD_RS17840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BD_RS17845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BD_RS17850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BD_RS17855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BD_RS17860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BD_RS17880	COG1192	Involved in chromosome partitioning
BD_RS17890	COG0357	Ribosomal RNA small subunit methyltransferase G
BD_RS17895	COG0445	tRNA wobble uridine modification
BD_RS17900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BD_RS17910	COG0706	membrane insertase activity
BD_RS17925	COG0840	transmembrane signaling receptor activity
BD_RS17960	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BD_RS17965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BD_RS17970	COG4251	negative regulation of phosphorylation
BD_RS17995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter