locus-tag	class	description
BDW_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BDW_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BDW_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BDW_RS00045	COG0356	it plays a direct role in the translocation of protons across the membrane
BDW_RS00050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BDW_RS00060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BDW_RS00065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BDW_RS00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BDW_RS00075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BDW_RS00085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BDW_RS00090	COG2086	electron transfer activity
BDW_RS00100	COG1053	succinate dehydrogenase
BDW_RS00120	COG1132	(ABC) transporter
BDW_RS00125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BDW_RS00135	COG0360	Binds together with S18 to 16S ribosomal RNA
BDW_RS00145	COG0359	binds to the 23S rRNA
BDW_RS00160	COG0305	Participates in initiation and elongation during chromosome replication
BDW_RS00170	COG0602	queuosine metabolic process
BDW_RS00190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BDW_RS00195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BDW_RS00200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BDW_RS00205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BDW_RS00235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BDW_RS00245	COG0154	amidase activity
BDW_RS00250	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BDW_RS00275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BDW_RS00280	COG0254	rRNA binding
BDW_RS00285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BDW_RS00290	COG2890	protein-(glutamine-N5) methyltransferase activity
BDW_RS00295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BDW_RS00315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BDW_RS00335	COG0586	Pfam SNARE associated Golgi protein
BDW_RS00345	COG0590	tRNA wobble adenosine to inosine editing
BDW_RS00365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BDW_RS00370	COG0668	transmembrane transport
BDW_RS00420	COG2843	Capsule synthesis protein
BDW_RS00430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BDW_RS00435	COG0459	protein refolding
BDW_RS00450	COG2201	protein-glutamate methylesterase activity
BDW_RS00520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BDW_RS00530	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BDW_RS00540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BDW_RS00555	COG1012	belongs to the aldehyde dehydrogenase family
BDW_RS00560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BDW_RS00570	COG0778	Nitroreductase
BDW_RS00575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BDW_RS00580	COG1217	gtp-binding protein TYPA
BDW_RS00600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BDW_RS00610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BDW_RS00645	COG0823	Involved in the tonB-independent uptake of proteins
BDW_RS00660	COG0811	peptide transport
BDW_RS00675	COG0719	Fe-S assembly protein
BDW_RS00680	COG0396	ATPase activity
BDW_RS00685	COG0719	Fe-S assembly protein
BDW_RS00690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BDW_RS00720	COG1722	exodeoxyribonuclease VII activity
BDW_RS00725	COG0142	geranyltranstransferase activity
BDW_RS00730	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BDW_RS00740	COG0006	proline dipeptidase activity
BDW_RS00755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BDW_RS00760	COG1077	Cell shape determining protein MreB Mrl
BDW_RS00775	COG5002	protein histidine kinase activity
BDW_RS00785	COG2003	Belongs to the UPF0758 family
BDW_RS00800	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BDW_RS00825	COG2766	serine protein kinase
BDW_RS00830	COG2718	Belongs to the UPF0229 family
BDW_RS00835	COG2719	SpoVR family
BDW_RS00840	COG0023	Translation Initiation Factor
BDW_RS00845	COG0745	RESPONSE REGULATOR receiver
BDW_RS00860	COG0513	Belongs to the DEAD box helicase family
BDW_RS00865	COG0590	tRNA wobble adenosine to inosine editing
BDW_RS00870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BDW_RS00875	COG1610	YqeY-like protein
BDW_RS00880	COG0358	DNA primase activity
BDW_RS00915	COG0702	epimerase
BDW_RS00920	COG0583	DNA-binding transcription factor activity
BDW_RS00935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BDW_RS00940	COG0509	glycine decarboxylation via glycine cleavage system
BDW_RS00945	COG0174	glutamine synthetase
BDW_RS00960	COG0653	protein targeting
BDW_RS00990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BDW_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
BDW_RS01015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BDW_RS01020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BDW_RS01025	COG1845	cytochrome c oxidase, subunit III
BDW_RS01035	COG0109	protoheme IX farnesyltransferase activity
BDW_RS01060	COG2032	superoxide dismutase activity
BDW_RS01070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BDW_RS01075	COG4566	intracellular signal transduction
BDW_RS01090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BDW_RS01110	COG0488	(ABC) transporter
BDW_RS01185	COG1252	NADH dehydrogenase
BDW_RS01190	COG1136	(ABC) transporter
BDW_RS01200	COG2223	nitrite transmembrane transporter activity
BDW_RS01210	COG2153	protein acetylation
BDW_RS01220	COG1047	Peptidyl-prolyl cis-trans
BDW_RS01225	COG1666	GTP binding
BDW_RS01230	COG0724	RNA recognition motif
BDW_RS01240	COG1136	(ABC) transporter
BDW_RS01255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BDW_RS01265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BDW_RS01270	COG1393	Belongs to the ArsC family
BDW_RS01275	COG0010	Belongs to the arginase family
BDW_RS01280	COG4166	transmembrane transport
BDW_RS01285	COG4174	ABC transporter (Permease)
BDW_RS01290	COG4239	(ABC) transporter, permease
BDW_RS01295	COG1166	arginine decarboxylase activity
BDW_RS01300	COG0495	leucyl-tRNA aminoacylation
BDW_RS01310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BDW_RS01315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BDW_RS01320	COG0785	Cytochrome C biogenesis protein
BDW_RS01335	COG0492	ferredoxin-NADP+ reductase activity
BDW_RS01340	COG0745	RESPONSE REGULATOR receiver
BDW_RS01360	COG4608	Belongs to the ABC transporter superfamily
BDW_RS01365	COG0444	Belongs to the ABC transporter superfamily
BDW_RS01385	COG0587	DNA-directed DNA polymerase activity
BDW_RS01415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BDW_RS01450	COG0739	heme binding
BDW_RS01470	COG0183	Belongs to the thiolase family
BDW_RS01480	COG1078	dGTPase activity
BDW_RS01490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BDW_RS01495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BDW_RS01515	COG0583	DNA-binding transcription factor activity
BDW_RS01520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BDW_RS01525	COG0557	exoribonuclease II activity
BDW_RS01550	COG5006	permease, DMT superfamily
BDW_RS01560	COG1079	Belongs to the binding-protein-dependent transport system permease family
BDW_RS01565	COG4603	Belongs to the binding-protein-dependent transport system permease family
BDW_RS01570	COG3845	ABC transporter
BDW_RS01575	COG1744	ABC transporter substrate-binding protein PnrA-like
BDW_RS01580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BDW_RS01585	COG1720	tRNA m6t6A37 methyltransferase activity
BDW_RS01600	COG0525	valine-tRNA ligase activity
BDW_RS01625	COG1872	DUF167
BDW_RS01640	COG0424	maF-like protein
BDW_RS01665	COG1716	ATPase activity
BDW_RS01680	COG0811	peptide transport
BDW_RS01705	COG1183	phosphatidylcholine synthase activity
BDW_RS01710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BDW_RS01730	COG0101	tRNA pseudouridine synthase activity
BDW_RS01735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BDW_RS01740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BDW_RS01745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BDW_RS01755	COG1408	metallophosphoesterase
BDW_RS01760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BDW_RS01765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BDW_RS01770	COG1058	Belongs to the CinA family
BDW_RS01770	COG1546	Belongs to the CinA family
BDW_RS01775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BDW_RS01780	COG0386	Belongs to the glutathione peroxidase family
BDW_RS01810	COG4786	Flagellar basal body rod
BDW_RS01825	COG1706	bacterial-type flagellum-dependent cell motility
BDW_RS01855	COG1256	bacterial-type flagellum assembly
BDW_RS01870	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BDW_RS01895	COG1575	Belongs to the MenA family. Type 1 subfamily
BDW_RS01905	COG0318	PFAM AMP-dependent synthetase and ligase
BDW_RS01925	COG0824	Thioesterase
BDW_RS01930	COG0142	geranyltranstransferase activity
BDW_RS01940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BDW_RS01955	COG0372	Belongs to the citrate synthase family
BDW_RS01985	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BDW_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
BDW_RS02005	COG1181	Belongs to the D-alanine--D-alanine ligase family
BDW_RS02010	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BDW_RS02030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BDW_RS02055	COG0784	Response regulator, receiver
BDW_RS02055	COG2205	protein histidine kinase activity
BDW_RS02065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BDW_RS02070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BDW_RS02085	COG1516	flagellar protein fliS
BDW_RS02110	COG0859	PFAM glycosyl transferase family 9
BDW_RS02130	COG0742	ribosomal rna small subunit methyltransferase
BDW_RS02135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BDW_RS02140	COG0436	Aminotransferase
BDW_RS02170	COG2885	chlorophyll binding
BDW_RS02185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BDW_RS02190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BDW_RS02195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BDW_RS02210	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BDW_RS02390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BDW_RS02400	COG3089	Belongs to the UPF0270 family
BDW_RS02415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BDW_RS02415	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BDW_RS02420	COG2814	Major facilitator Superfamily
BDW_RS02440	COG0312	modulator of DNA gyrase
BDW_RS02460	COG0776	regulation of translation
BDW_RS02475	COG0494	nUDIX hydrolase
BDW_RS02480	COG0167	dihydroorotate dehydrogenase activity
BDW_RS02485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BDW_RS02495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BDW_RS02495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BDW_RS02505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BDW_RS02525	COG0166	Belongs to the GPI family
BDW_RS02530	COG3706	GGDEF domain
BDW_RS02580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BDW_RS02595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BDW_RS02600	COG2030	dehydratase
BDW_RS02630	COG4772	TonB-dependent receptor
BDW_RS02635	COG1840	ABC-type Fe3 transport system, periplasmic component
BDW_RS02640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BDW_RS02665	COG1489	DNA binding
BDW_RS02670	COG0517	IMP dehydrogenase activity
BDW_RS02680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BDW_RS02680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BDW_RS02710	COG0148	phosphopyruvate hydratase activity
BDW_RS02725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BDW_RS02725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BDW_RS02740	COG2204	response regulator
BDW_RS02745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BDW_RS02750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BDW_RS02755	COG0504	CTP synthase activity
BDW_RS02760	COG0517	IMP dehydrogenase activity
BDW_RS02760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BDW_RS02765	COG2942	2-epimerase
BDW_RS02770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BDW_RS02810	COG0811	peptide transport
BDW_RS02830	COG1137	ATPase activity
BDW_RS02845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BDW_RS02850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BDW_RS02855	COG0481	GTPase activity
BDW_RS02860	COG0681	Belongs to the peptidase S26 family
BDW_RS02865	COG0681	Belongs to the peptidase S26 family
BDW_RS02870	COG0681	Belongs to the peptidase S26 family
BDW_RS02875	COG0540	Belongs to the ATCase OTCase family
BDW_RS02885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BDW_RS02895	COG1131	(ABC) transporter
BDW_RS02940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BDW_RS02980	COG2267	carboxylic ester hydrolase activity
BDW_RS03005	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BDW_RS03015	COG1595	DNA-templated transcription, initiation
BDW_RS03035	COG0739	heme binding
BDW_RS03050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BDW_RS03055	COG0488	(ABC) transporter
BDW_RS03070	COG0783	Belongs to the Dps family
BDW_RS03080	COG3321	synthase
BDW_RS03080	COG0604	alcohol dehydrogenase
BDW_RS03095	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BDW_RS03095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BDW_RS03105	COG3135	benzoate transporter
BDW_RS03110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BDW_RS03140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BDW_RS03205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BDW_RS03210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BDW_RS03215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BDW_RS03235	COG0644	oxidoreductase
BDW_RS03235	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BDW_RS03255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BDW_RS03265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BDW_RS03275	COG0312	modulator of DNA gyrase
BDW_RS03280	COG0312	modulator of DNA gyrase
BDW_RS03295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BDW_RS03305	COG0793	Belongs to the peptidase S41A family
BDW_RS03320	COG0022	dehydrogenase e1 component
BDW_RS03340	COG2801	Transposase and inactivated derivatives
BDW_RS03350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BDW_RS03360	COG1253	flavin adenine dinucleotide binding
BDW_RS03370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BDW_RS03375	COG0514	ATP-dependent DNA helicase (RecQ)
BDW_RS03385	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BDW_RS03405	COG0488	(ABC) transporter
BDW_RS03430	COG0357	Ribosomal RNA small subunit methyltransferase G
BDW_RS03435	COG3384	dioxygenase
BDW_RS03445	COG0583	DNA-binding transcription factor activity
BDW_RS03455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BDW_RS03460	COG0248	Ppx GppA phosphatase
BDW_RS03470	COG0704	Plays a role in the regulation of phosphate uptake
BDW_RS03475	COG0745	RESPONSE REGULATOR receiver
BDW_RS03480	COG5002	protein histidine kinase activity
BDW_RS03500	COG1131	(ABC) transporter
BDW_RS03530	COG1073	alpha beta
BDW_RS03535	COG4106	trans-aconitate 2-methyltransferase activity
BDW_RS03540	COG0598	Magnesium transport protein CorA
BDW_RS03570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BDW_RS03580	COG0084	hydrolase, TatD family'
BDW_RS03590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BDW_RS03595	COG0126	phosphoglycerate kinase activity
BDW_RS03600	COG0149	triose-phosphate isomerase activity
BDW_RS03615	COG3209	COG3209 Rhs family protein
BDW_RS03625	COG3209	COG3209 Rhs family protein
BDW_RS03655	COG0017	Asparaginyl-tRNA synthetase
BDW_RS03660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BDW_RS03680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BDW_RS03685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BDW_RS03700	COG0616	signal peptide processing
BDW_RS03725	COG1580	Controls the rotational direction of flagella during chemotaxis
BDW_RS03730	COG0612	Peptidase, M16
BDW_RS03750	COG0583	DNA-binding transcription factor activity
BDW_RS03755	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BDW_RS03770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BDW_RS03775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BDW_RS03785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BDW_RS03785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BDW_RS03795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BDW_RS03800	COG0124	histidyl-tRNA synthetase
BDW_RS03815	COG4181	ATPase activity
BDW_RS03825	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BDW_RS03855	COG3942	CHAP domain
BDW_RS03855	COG1388	LysM domain
BDW_RS03870	COG0489	protein tyrosine kinase activity
BDW_RS03895	COG0423	glycine-tRNA ligase activity
BDW_RS03900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BDW_RS03900	COG0574	Belongs to the PEP-utilizing enzyme family
BDW_RS03915	COG1196	nuclear chromosome segregation
BDW_RS03925	COG0697	spore germination
BDW_RS03955	COG0552	protein localization to endoplasmic reticulum
BDW_RS03960	COG2801	Transposase and inactivated derivatives
BDW_RS03990	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BDW_RS03995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BDW_RS04000	COG1418	mRNA catabolic process
BDW_RS04005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BDW_RS04015	COG0596	Alpha beta hydrolase
BDW_RS04020	COG0625	glutathione transferase activity
BDW_RS04060	COG0316	Belongs to the HesB IscA family
BDW_RS04065	COG1104	cysteine desulfurase activity
BDW_RS04070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BDW_RS04075	COG0539	negative regulation of cytoplasmic translation
BDW_RS04080	COG1546	Belongs to the CinA family
BDW_RS04080	COG1058	Belongs to the CinA family
BDW_RS04085	COG1960	acyl-CoA dehydrogenase activity
BDW_RS04095	COG5599	Phosphatase
BDW_RS04105	COG1704	LemA family
BDW_RS04110	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BDW_RS04145	COG2076	Multidrug Resistance protein
BDW_RS04155	COG2855	membrane
BDW_RS04180	COG1741	Belongs to the pirin family
BDW_RS04185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BDW_RS04230	COG2356	endonuclease I
BDW_RS04245	COG1012	belongs to the aldehyde dehydrogenase family
BDW_RS04250	COG0179	Fumarylacetoacetate (FAA) hydrolase
BDW_RS04260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BDW_RS04265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BDW_RS04275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BDW_RS04300	COG0473	3-isopropylmalate dehydrogenase activity
BDW_RS04345	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BDW_RS04355	COG1404	Belongs to the peptidase S8 family
BDW_RS04380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BDW_RS04385	COG4968	Prepilin-type N-terminal cleavage methylation domain
BDW_RS04395	COG0484	heat shock protein binding
BDW_RS04400	COG0443	Heat shock 70 kDa protein
BDW_RS04405	COG0730	response to heat
BDW_RS04440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BDW_RS04480	COG3012	SEC-C Motif Domain Protein
BDW_RS04485	COG4221	oxidoreductase activity
BDW_RS04525	COG0271	Belongs to the BolA IbaG family
BDW_RS04535	COG0488	(ABC) transporter
BDW_RS04555	COG0024	Methionine aminopeptidase
BDW_RS04565	COG4335	DNA alkylation repair
BDW_RS04575	COG0745	RESPONSE REGULATOR receiver
BDW_RS04575	COG4566	intracellular signal transduction
BDW_RS04635	COG0724	RNA recognition motif
BDW_RS04640	COG1047	Peptidyl-prolyl cis-trans
BDW_RS04645	COG0513	Belongs to the DEAD box helicase family
BDW_RS04650	COG0708	Exodeoxyribonuclease III
BDW_RS04660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BDW_RS04670	COG3191	aminopeptidase activity
BDW_RS04685	COG2828	Protein conserved in bacteria
BDW_RS04700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BDW_RS04720	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
BDW_RS04735	COG0488	(ABC) transporter
BDW_RS04740	COG2270	Major facilitator Superfamily
BDW_RS04745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BDW_RS04750	COG0564	pseudouridine synthase activity
BDW_RS04755	COG1404	Belongs to the peptidase S8 family
BDW_RS04765	COG1404	Belongs to the peptidase S8 family
BDW_RS04790	COG0427	acetyl-CoA hydrolase
BDW_RS04875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BDW_RS04880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BDW_RS04885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BDW_RS04895	COG1466	dna polymerase III delta subunit
BDW_RS04915	COG0268	Binds directly to 16S ribosomal RNA
BDW_RS04920	COG0728	peptidoglycan biosynthetic process
BDW_RS04965	COG0811	peptide transport
BDW_RS04990	COG3956	TIGRFAM MazG family protein
BDW_RS04995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BDW_RS05000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BDW_RS05010	COG1136	(ABC) transporter
BDW_RS05015	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BDW_RS05025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BDW_RS05030	COG0673	inositol 2-dehydrogenase activity
BDW_RS05035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BDW_RS05040	COG1663	tetraacyldisaccharide 4'-kinase activity
BDW_RS05045	COG1560	Kdo2-lipid A biosynthetic process
BDW_RS05070	COG2204	response regulator
BDW_RS05075	COG2205	protein histidine kinase activity
BDW_RS05080	COG0196	riboflavin kinase activity
BDW_RS05090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BDW_RS05100	COG1459	type II secretion system
BDW_RS05105	COG3852	Histidine kinase
BDW_RS05110	COG2204	response regulator
BDW_RS05155	COG0248	Ppx GppA phosphatase
BDW_RS05185	COG0443	Heat shock 70 kDa protein
BDW_RS05215	COG0779	Required for maturation of 30S ribosomal subunits
BDW_RS05225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BDW_RS05230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BDW_RS05235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BDW_RS05240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BDW_RS05245	COG1185	polyribonucleotide nucleotidyltransferase activity
BDW_RS05250	COG0612	Peptidase, M16
BDW_RS05255	COG0756	dUTP diphosphatase activity
BDW_RS05280	COG0463	Glycosyl transferase, family 2
BDW_RS05290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BDW_RS05295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BDW_RS05300	COG1561	YicC-like family, N-terminal region
BDW_RS05305	COG0194	GDP metabolic process
BDW_RS05310	COG1758	RNA polymerase activity
BDW_RS05335	COG0629	single-stranded DNA binding
BDW_RS05385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BDW_RS05440	COG2096	Adenosyltransferase
BDW_RS05450	COG1333	cytochrome c biogenesis protein
BDW_RS05450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BDW_RS05455	COG1333	cytochrome c biogenesis protein
BDW_RS05455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BDW_RS05465	COG0437	4 iron, 4 sulfur cluster binding
BDW_RS05505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BDW_RS05510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BDW_RS05555	COG0848	biopolymer transport protein
BDW_RS05570	COG0840	transmembrane signaling receptor activity
BDW_RS05580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BDW_RS05585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BDW_RS05590	COG1304	FMN binding
BDW_RS05620	COG1271	oxidase subunit
BDW_RS05625	COG1764	response to oxidative stress
BDW_RS05630	COG1253	flavin adenine dinucleotide binding
BDW_RS05645	COG0357	Ribosomal RNA small subunit methyltransferase G
BDW_RS05645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BDW_RS05650	COG0357	Ribosomal RNA small subunit methyltransferase G
BDW_RS05655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BDW_RS05660	COG0072	phenylalanine-tRNA ligase activity
BDW_RS05660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BDW_RS05665	COG0776	regulation of translation
BDW_RS05695	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BDW_RS05705	COG0583	DNA-binding transcription factor activity
BDW_RS05745	COG0735	belongs to the Fur family
BDW_RS05755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BDW_RS05760	COG0573	inorganic phosphate transmembrane transporter activity
BDW_RS05765	COG0581	inorganic phosphate transmembrane transporter activity
BDW_RS05770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BDW_RS05775	COG0840	transmembrane signaling receptor activity
BDW_RS05825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BDW_RS05885	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BDW_RS05920	COG3550	peptidyl-serine autophosphorylation
BDW_RS05990	COG1335	isochorismatase
BDW_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
BDW_RS06015	COG3021	interspecies interaction between organisms
BDW_RS06040	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BDW_RS06055	COG1858	cytochrome C peroxidase
BDW_RS06060	COG1720	tRNA m6t6A37 methyltransferase activity
BDW_RS06070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BDW_RS06070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BDW_RS06080	COG1077	Cell shape determining protein MreB Mrl
BDW_RS06270	COG1192	Involved in chromosome partitioning
BDW_RS06290	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BDW_RS06310	COG0726	polysaccharide deacetylase
BDW_RS06320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BDW_RS06320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BDW_RS06345	COG0753	catalase activity
BDW_RS06370	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BDW_RS06380	COG0346	lactoylglutathione lyase activity
BDW_RS06405	COG2900	Belongs to the SlyX family
BDW_RS06450	COG2076	Multidrug Resistance protein
BDW_RS06480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BDW_RS06485	COG2884	Cell division ATP-binding protein ftsE
BDW_RS06495	COG4591	ABC-type transport system involved in lipoprotein release permease component
BDW_RS06510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BDW_RS06515	COG0517	IMP dehydrogenase activity
BDW_RS06515	COG0516	GMP reductase activity
BDW_RS06525	COG1012	belongs to the aldehyde dehydrogenase family
BDW_RS06540	COG0693	protein deglycase activity
BDW_RS06545	COG0564	pseudouridine synthase activity
BDW_RS06570	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BDW_RS06585	COG0318	PFAM AMP-dependent synthetase and ligase
BDW_RS06595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BDW_RS06600	COG3483	tryptophan 2,3-dioxygenase activity
BDW_RS06620	COG1402	creatininase
BDW_RS06645	COG0617	tRNA 3'-terminal CCA addition
BDW_RS06670	COG2197	response regulator
BDW_RS06675	COG1607	acyl-coa hydrolase
BDW_RS06690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BDW_RS06695	COG0280	phosphate acetyltransferase
BDW_RS06695	COG0281	malic enzyme
BDW_RS06700	COG0183	Belongs to the thiolase family
BDW_RS06705	COG1024	Enoyl-CoA hydratase
BDW_RS06705	COG1250	3-hydroxyacyl-CoA dehydrogenase
BDW_RS06715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BDW_RS06755	COG1720	tRNA m6t6A37 methyltransferase activity
BDW_RS06760	COG1505	serine-type exopeptidase activity
BDW_RS06780	COG0824	Thioesterase
BDW_RS06785	COG1494	fructose-1,6-bisphosphatase
BDW_RS06815	COG1012	belongs to the aldehyde dehydrogenase family
BDW_RS06820	COG0037	tRNA processing
BDW_RS06825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BDW_RS06830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BDW_RS06835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BDW_RS06860	COG1104	cysteine desulfurase activity
BDW_RS06865	COG0482	sulfurtransferase activity
BDW_RS06870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BDW_RS06875	COG0571	ribonuclease III activity
BDW_RS06880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BDW_RS06885	COG1160	GTP binding
BDW_RS06890	COG0733	neurotransmitter:sodium symporter activity
BDW_RS06900	COG0386	Belongs to the glutathione peroxidase family
BDW_RS06910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BDW_RS06920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BDW_RS06925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BDW_RS06960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BDW_RS06985	COG2166	iron-sulfur cluster assembly
BDW_RS07000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BDW_RS07005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BDW_RS07010	COG0183	Belongs to the thiolase family
BDW_RS07040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BDW_RS07055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BDW_RS07060	COG0516	GMP reductase activity
BDW_RS07060	COG0517	IMP dehydrogenase activity
BDW_RS07065	COG0519	Catalyzes the synthesis of GMP from XMP
BDW_RS07065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BDW_RS07090	COG0183	Belongs to the thiolase family
BDW_RS07110	COG0625	glutathione transferase activity
BDW_RS07115	COG0037	tRNA processing
BDW_RS07145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BDW_RS07175	COG1837	Belongs to the UPF0109 family
BDW_RS07200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BDW_RS07235	COG0840	transmembrane signaling receptor activity
BDW_RS07240	COG0018	arginyl-trna synthetase
BDW_RS07250	COG0582	viral genome integration into host DNA
BDW_RS07260	COG1116	anion transmembrane transporter activity
BDW_RS07265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BDW_RS07280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BDW_RS07285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BDW_RS07300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BDW_RS07305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BDW_RS07310	COG0698	ribose 5-phosphate isomerase
BDW_RS07315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BDW_RS07340	COG3158	transport of potassium into the cell
BDW_RS07345	COG0431	NADPH-dependent FMN reductase
BDW_RS07360	COG1242	4 iron, 4 sulfur cluster binding
BDW_RS07370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BDW_RS07395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BDW_RS07400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BDW_RS07405	COG0180	Tryptophanyl-tRNA synthetase
BDW_RS07410	COG1994	Peptidase M50
BDW_RS07415	COG1960	acyl-CoA dehydrogenase activity
BDW_RS07420	COG4166	transmembrane transport
BDW_RS07425	COG1716	ATPase activity
BDW_RS07425	COG5001	Diguanylate cyclase
BDW_RS07445	COG1187	pseudouridine synthase activity
BDW_RS07455	COG0505	Belongs to the CarA family
BDW_RS07470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BDW_RS07480	COG0217	transcriptional regulatory protein
BDW_RS07490	COG2353	YceI-like domain
BDW_RS07530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BDW_RS07565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BDW_RS07570	COG0335	large ribosomal subunit rRNA binding
BDW_RS07575	COG0336	Belongs to the RNA methyltransferase TrmD family
BDW_RS07575	COG4752	Belongs to the RNA methyltransferase TrmD family
BDW_RS07580	COG0336	Belongs to the RNA methyltransferase TrmD family
BDW_RS07585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BDW_RS07595	COG0228	four-way junction DNA binding
BDW_RS07600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BDW_RS07605	COG0842	Transport permease protein
BDW_RS07610	COG1131	(ABC) transporter
BDW_RS07615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BDW_RS07620	COG1054	Belongs to the UPF0176 family
BDW_RS07645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BDW_RS07650	COG1999	signal sequence binding
BDW_RS07685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BDW_RS07690	COG1028	Short-chain dehydrogenase reductase Sdr
BDW_RS07705	COG0513	Belongs to the DEAD box helicase family
BDW_RS07745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BDW_RS07775	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BDW_RS07785	COG2176	DNA-directed DNA polymerase activity
BDW_RS07790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BDW_RS07805	COG0628	permease
BDW_RS07810	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BDW_RS07810	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BDW_RS07835	COG0038	chloride channel
BDW_RS07840	COG2070	2-Nitropropane dioxygenase
BDW_RS07860	COG0730	response to heat
BDW_RS07870	COG2814	Major facilitator Superfamily
BDW_RS07880	COG1418	mRNA catabolic process
BDW_RS07885	COG2205	protein histidine kinase activity
BDW_RS07885	COG0784	Response regulator, receiver
BDW_RS07900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BDW_RS07920	COG0616	signal peptide processing
BDW_RS07925	COG0444	Belongs to the ABC transporter superfamily
BDW_RS07930	COG4608	Belongs to the ABC transporter superfamily
BDW_RS07935	COG0747	negative chemotaxis
BDW_RS07940	COG0601	transmembrane transport
BDW_RS07945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BDW_RS07955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BDW_RS07965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BDW_RS07975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BDW_RS08005	COG0720	synthase
BDW_RS08020	COG2261	transglycosylase associated protein
BDW_RS08035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BDW_RS08035	COG1703	isobutyryl-CoA mutase activity
BDW_RS08035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BDW_RS08040	COG1024	Enoyl-CoA hydratase
BDW_RS08045	COG1250	3-hydroxyacyl-CoA dehydrogenase
BDW_RS08075	COG1090	epimerase
BDW_RS08080	COG0415	Belongs to the DNA photolyase family
BDW_RS08085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BDW_RS08120	COG1612	heme a metabolic process
BDW_RS08120	COG0109	protoheme IX farnesyltransferase activity
BDW_RS08170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BDW_RS08175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BDW_RS08175	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BDW_RS08180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BDW_RS08185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BDW_RS08195	COG0343	queuine tRNA-ribosyltransferase activity
BDW_RS08200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BDW_RS08255	COG3104	oligopeptide transport
BDW_RS08290	COG4206	TonB-dependent receptor
BDW_RS08305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BDW_RS08320	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BDW_RS08325	COG0709	Synthesizes selenophosphate from selenide and ATP
BDW_RS08340	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BDW_RS08420	COG2385	sporulation resulting in formation of a cellular spore
BDW_RS08450	COG0728	peptidoglycan biosynthetic process
BDW_RS08455	COG0322	excinuclease ABC activity
BDW_RS08460	COG0556	nucleotide-excision repair
BDW_RS08480	COG0215	cysteine-tRNA ligase activity
BDW_RS08485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BDW_RS08495	COG1404	Belongs to the peptidase S8 family
BDW_RS08505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BDW_RS08540	COG2205	protein histidine kinase activity
BDW_RS08540	COG0784	Response regulator, receiver
BDW_RS08555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BDW_RS08560	COG1830	Aldolase
BDW_RS08565	COG0316	Belongs to the HesB IscA family
BDW_RS08565	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BDW_RS08605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BDW_RS08610	COG0084	hydrolase, TatD family'
BDW_RS08645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BDW_RS08645	COG0116	Belongs to the methyltransferase superfamily
BDW_RS08715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BDW_RS08730	COG0745	RESPONSE REGULATOR receiver
BDW_RS08750	COG2198	Histidine kinase
BDW_RS08750	COG0643	Histidine kinase
BDW_RS08755	COG0326	Molecular chaperone. Has ATPase activity
BDW_RS08775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BDW_RS08780	COG0717	Belongs to the dCTP deaminase family
BDW_RS08820	COG0784	Response regulator, receiver
BDW_RS08820	COG3437	response regulator, receiver
BDW_RS08885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BDW_RS08890	COG0735	belongs to the Fur family
BDW_RS08895	COG1469	GTP cyclohydrolase I activity
BDW_RS08900	COG0424	maF-like protein
BDW_RS08905	COG0295	cytidine deaminase activity
BDW_RS08940	COG0768	penicillin binding
BDW_RS08945	COG0772	Belongs to the SEDS family
BDW_RS08980	COG0758	DNA mediated transformation
BDW_RS09000	COG0658	competence protein
BDW_RS09000	COG2333	competence protein COMEC
BDW_RS09010	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BDW_RS09020	COG2255	four-way junction helicase activity
BDW_RS09025	COG0632	four-way junction helicase activity
BDW_RS09030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BDW_RS09040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BDW_RS09075	COG2079	MmgE PrpD family protein
BDW_RS09080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BDW_RS09095	COG0095	Lipoate-protein ligase
BDW_RS09115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BDW_RS09140	COG0450	alkyl hydroperoxide reductase
BDW_RS09155	COG0308	aminopeptidase N
BDW_RS09160	COG0302	gtp cyclohydrolase
BDW_RS09200	COG1132	(ABC) transporter
BDW_RS09205	COG1132	(ABC) transporter
BDW_RS09210	COG2239	Acts as a magnesium transporter
BDW_RS09235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BDW_RS09245	COG2967	ApaG domain
BDW_RS09255	COG0259	pyridoxamine-phosphate oxidase activity
BDW_RS09260	COG0545	Peptidyl-prolyl cis-trans isomerase
BDW_RS09290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BDW_RS09295	COG2217	Heavy metal translocating P-type atpase
BDW_RS09305	COG3278	Belongs to the heme-copper respiratory oxidase family
BDW_RS09315	COG0348	domain, Protein
BDW_RS09345	COG0786	glutamate:sodium symporter activity
BDW_RS09365	COG2824	Alkylphosphonate utilization operon protein PhnA
BDW_RS09450	COG1061	Type III restriction enzyme res subunit
BDW_RS09490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BDW_RS09520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BDW_RS09535	COG1024	Enoyl-CoA hydratase
BDW_RS09545	COG1968	undecaprenyl-diphosphatase activity
BDW_RS09555	COG0860	N-Acetylmuramoyl-L-alanine amidase
BDW_RS09560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BDW_RS09565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BDW_RS09570	COG2375	cellular response to nickel ion
BDW_RS09580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BDW_RS09585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BDW_RS09590	COG0193	aminoacyl-tRNA hydrolase activity
BDW_RS09595	COG0012	GTP binding
BDW_RS09605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BDW_RS09610	COG0601	transmembrane transport
BDW_RS09615	COG0741	lytic transglycosylase activity
BDW_RS09620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BDW_RS09625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BDW_RS09635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BDW_RS09655	COG1228	amidohydrolase
BDW_RS09680	COG0588	phosphoglycerate mutase activity
BDW_RS09685	COG0567	Dehydrogenase, E1 component
BDW_RS09690	COG0508	dehydrogenase complex catalyzes the overall conversion of
BDW_RS09730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BDW_RS09735	COG2986	histidine ammonia-lyase
BDW_RS09790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BDW_RS09795	COG0242	peptide deformylase activity
BDW_RS09815	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BDW_RS09815	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BDW_RS09835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BDW_RS09840	COG4558	Periplasmic binding protein
BDW_RS09845	COG4771	TonB-dependent receptor
BDW_RS09910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BDW_RS09920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BDW_RS09925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BDW_RS09960	COG2304	oxidoreductase activity
BDW_RS09980	COG0714	Associated with various cellular activities
BDW_RS09985	COG0501	Belongs to the peptidase M48B family
BDW_RS09995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BDW_RS10000	COG2088	sporulation resulting in formation of a cellular spore
BDW_RS10070	COG0798	PFAM Bile acid sodium symporter
BDW_RS10075	COG0431	NADPH-dependent FMN reductase
BDW_RS10080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BDW_RS10085	COG2072	flavoprotein involved in K transport
BDW_RS10140	COG2132	Multicopper oxidase
BDW_RS10160	COG2356	endonuclease I
BDW_RS10170	COG0724	RNA recognition motif
BDW_RS10175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BDW_RS10180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BDW_RS10200	COG1132	(ABC) transporter
BDW_RS10220	COG2205	protein histidine kinase activity
BDW_RS10225	COG0745	RESPONSE REGULATOR receiver
BDW_RS10245	COG0789	Transcriptional regulator
BDW_RS10250	COG2217	Heavy metal translocating P-type atpase
BDW_RS10260	COG0668	transmembrane transport
BDW_RS10275	COG0431	NADPH-dependent FMN reductase
BDW_RS10305	COG0071	Belongs to the small heat shock protein (HSP20) family
BDW_RS10310	COG1027	Aspartate ammonia-lyase
BDW_RS10365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BDW_RS10375	COG0277	FAD linked oxidase domain protein
BDW_RS10395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BDW_RS10400	COG2204	response regulator
BDW_RS10405	COG4589	Belongs to the CDS family
BDW_RS10415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BDW_RS10420	COG1295	ribonuclease BN
BDW_RS10430	COG2119	membrane
BDW_RS10445	COG1215	transferase activity, transferring glycosyl groups
BDW_RS10465	COG0438	transferase activity, transferring glycosyl groups
BDW_RS10480	COG2801	Transposase and inactivated derivatives
BDW_RS10485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BDW_RS10535	COG0783	Belongs to the Dps family
BDW_RS10560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BDW_RS10575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BDW_RS10585	COG3459	Glycosyltransferase 36 associated
BDW_RS10600	COG1960	acyl-CoA dehydrogenase activity
BDW_RS10630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BDW_RS10645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BDW_RS10650	COG0203	ribosomal protein L17
BDW_RS10655	COG0202	RNA polymerase activity
BDW_RS10660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BDW_RS10665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BDW_RS10670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BDW_RS10675	COG0563	adenylate kinase activity
BDW_RS10680	COG0201	protein transport
BDW_RS10685	COG0200	Binds to the 23S rRNA
BDW_RS10690	COG1841	ribosomal large subunit assembly
BDW_RS10695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BDW_RS10700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BDW_RS10705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BDW_RS10710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BDW_RS10715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BDW_RS10720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BDW_RS10725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BDW_RS10730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BDW_RS10735	COG0255	Belongs to the universal ribosomal protein uL29 family
BDW_RS10740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BDW_RS10745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BDW_RS10750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BDW_RS10755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BDW_RS10760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BDW_RS10765	COG0089	rRNA binding
BDW_RS10770	COG0088	Forms part of the polypeptide exit tunnel
BDW_RS10775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BDW_RS10780	COG0051	transcription antitermination factor activity, RNA binding
BDW_RS10785	COG1136	(ABC) transporter
BDW_RS10785	COG0577	efflux transmembrane transporter activity
BDW_RS10790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BDW_RS10800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BDW_RS10805	COG0049	tRNA binding
BDW_RS10810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BDW_RS10815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BDW_RS10820	COG0085	RNA polymerase activity
BDW_RS10830	COG0222	ribosome binding
BDW_RS10835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BDW_RS10840	COG0081	regulation of translation
BDW_RS10845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BDW_RS10850	COG0250	Participates in transcription elongation, termination and antitermination
BDW_RS10865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BDW_RS10890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BDW_RS10895	COG0284	orotidine-5'-phosphate decarboxylase activity
BDW_RS10905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BDW_RS10910	COG0138	bifunctional purine biosynthesis protein purh
BDW_RS10915	COG0047	phosphoribosylformylglycinamidine synthase activity
BDW_RS10920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BDW_RS10925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BDW_RS10930	COG0151	Belongs to the GarS family
BDW_RS10945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BDW_RS10965	COG2204	response regulator
BDW_RS10970	COG5000	phosphorelay sensor kinase activity
BDW_RS10975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BDW_RS10980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BDW_RS10980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BDW_RS10985	COG0307	riboflavin synthase, alpha
BDW_RS11000	COG0542	response to heat
BDW_RS11010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BDW_RS11075	COG2204	response regulator
BDW_RS11085	COG1381	Involved in DNA repair and RecF pathway recombination
BDW_RS11120	COG0583	DNA-binding transcription factor activity
BDW_RS11130	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BDW_RS11140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BDW_RS11145	COG1034	ATP synthesis coupled electron transport
BDW_RS11155	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BDW_RS11160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BDW_RS11160	COG0649	NAD binding
BDW_RS11165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BDW_RS11185	COG1132	(ABC) transporter
BDW_RS11190	COG1132	(ABC) transporter
BDW_RS11220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BDW_RS11225	COG1643	Atp-dependent helicase
BDW_RS11235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BDW_RS11240	COG1045	serine acetyltransferase
BDW_RS11245	COG3481	metal-dependent phosphohydrolase, HD sub domain
BDW_RS11270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BDW_RS11275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BDW_RS11305	COG0300	oxidoreductase activity
BDW_RS11310	COG0328	RNA-DNA hybrid ribonuclease activity
BDW_RS11370	COG0237	dephospho-CoA kinase activity
BDW_RS11380	COG1022	Amp-dependent synthetase and ligase
BDW_RS11400	COG3848	Pyruvate phosphate dikinase
BDW_RS11400	COG0574	Belongs to the PEP-utilizing enzyme family
BDW_RS11430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BDW_RS11445	COG1136	(ABC) transporter
BDW_RS11445	COG0577	efflux transmembrane transporter activity
BDW_RS11450	COG1136	(ABC) transporter
BDW_RS11470	COG0339	signal peptide processing
BDW_RS11475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BDW_RS11480	COG0497	DNA recombination
BDW_RS11490	COG1770	oligopeptidase
BDW_RS11500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BDW_RS11515	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BDW_RS11520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BDW_RS11530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BDW_RS11535	COG0840	transmembrane signaling receptor activity
BDW_RS11540	COG0405	Gamma-glutamyltransferase
BDW_RS11545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BDW_RS11550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BDW_RS11565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BDW_RS11570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BDW_RS11585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BDW_RS11590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BDW_RS11595	COG0596	Alpha beta hydrolase
BDW_RS11610	COG0514	ATP-dependent DNA helicase (RecQ)
BDW_RS11615	COG0768	penicillin binding
BDW_RS11625	COG0275	rRNA processing
BDW_RS11635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BDW_RS11645	COG1741	Belongs to the pirin family
BDW_RS11650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BDW_RS11655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BDW_RS11665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BDW_RS11690	COG2027	D-alanyl-D-alanine carboxypeptidase
BDW_RS11705	COG2176	DNA-directed DNA polymerase activity
BDW_RS11715	COG1360	Flagellar Motor Protein
BDW_RS11720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BDW_RS11725	COG4232	protein-disulfide reductase activity
BDW_RS11730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BDW_RS11740	COG2801	Transposase and inactivated derivatives
BDW_RS11755	COG1187	pseudouridine synthase activity
BDW_RS11770	COG2264	protein methyltransferase activity
BDW_RS11775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BDW_RS11830	COG0726	polysaccharide deacetylase
BDW_RS11870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BDW_RS11915	COG2204	response regulator
BDW_RS11920	COG4964	Belongs to the GSP D family
BDW_RS11945	COG1511	domain protein
BDW_RS11945	COG3264	Mechanosensitive ion channel
BDW_RS11950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BDW_RS11960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BDW_RS11975	COG1191	sigma factor activity
BDW_RS11985	COG1419	protein localization to endoplasmic reticulum
BDW_RS11990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BDW_RS11995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BDW_RS12000	COG1684	flagellar biosynthetic protein fliR
BDW_RS12005	COG1987	bacterial-type flagellum assembly
BDW_RS12010	COG1338	Plays a role in the flagellum-specific transport system
BDW_RS12035	COG3237	CsbD-like
BDW_RS12070	COG0210	DNA helicase
BDW_RS12185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BDW_RS12235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BDW_RS12240	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BDW_RS12245	COG5002	protein histidine kinase activity
BDW_RS12255	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BDW_RS12260	COG1121	(ABC) transporter
BDW_RS12280	COG2801	Transposase and inactivated derivatives
BDW_RS12310	COG0205	6-phosphofructokinase activity
BDW_RS12330	COG0411	ABC transporter
BDW_RS12340	COG2205	protein histidine kinase activity
BDW_RS12345	COG0745	RESPONSE REGULATOR receiver
BDW_RS12350	COG5002	protein histidine kinase activity
BDW_RS12355	COG0745	RESPONSE REGULATOR receiver
BDW_RS12370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BDW_RS12390	COG1157	protein secretion by the type III secretion system
BDW_RS12400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BDW_RS12410	COG1677	Flagellar hook-basal body complex protein FliE
BDW_RS12420	COG1815	bacterial-type flagellum-dependent cell motility
BDW_RS12425	COG2204	response regulator
BDW_RS12440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BDW_RS12445	COG1127	ABC transporter
BDW_RS12465	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BDW_RS12470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BDW_RS12480	COG2801	Transposase and inactivated derivatives
BDW_RS12485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BDW_RS12490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BDW_RS12500	COG1011	Hydrolase
BDW_RS12510	COG2204	response regulator
BDW_RS12540	COG3876	Protein conserved in bacteria
BDW_RS12545	COG0113	porphobilinogen synthase activity
BDW_RS12555	COG0181	hydroxymethylbilane synthase activity
BDW_RS12560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BDW_RS12570	COG0745	RESPONSE REGULATOR receiver
BDW_RS12575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BDW_RS12580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BDW_RS12590	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BDW_RS12595	COG1346	cytolysis
BDW_RS12620	COG0596	Alpha beta hydrolase
BDW_RS12625	COG0617	tRNA 3'-terminal CCA addition
BDW_RS12630	COG2201	protein-glutamate methylesterase activity
BDW_RS12635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BDW_RS12645	COG0835	chemotaxis
BDW_RS12655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BDW_RS12660	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BDW_RS12685	COG0596	Alpha beta hydrolase
BDW_RS12690	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BDW_RS12700	COG1605	Chorismate mutase
BDW_RS12700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BDW_RS12705	COG2226	methyltransferase
BDW_RS12715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BDW_RS12720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BDW_RS12725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BDW_RS12745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BDW_RS12755	COG0667	Aldo Keto reductase
BDW_RS12785	COG1309	transcriptional regulator
BDW_RS12790	COG0768	penicillin binding
BDW_RS12800	COG0708	Exodeoxyribonuclease III
BDW_RS12820	COG0793	Belongs to the peptidase S41A family
BDW_RS12825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BDW_RS12830	COG3186	Phenylalanine-4-hydroxylase
BDW_RS12855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BDW_RS12855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BDW_RS12865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BDW_RS12900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BDW_RS12905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BDW_RS12910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BDW_RS12915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BDW_RS12920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BDW_RS12935	COG0488	(ABC) transporter
BDW_RS12960	COG4770	biotin carboxylase activity
BDW_RS12965	COG0439	Biotin carboxylase
BDW_RS12970	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BDW_RS12975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BDW_RS12990	COG4106	trans-aconitate 2-methyltransferase activity
BDW_RS13010	COG0784	Response regulator, receiver
BDW_RS13010	COG2205	protein histidine kinase activity
BDW_RS13080	COG0069	glutamate synthase activity
BDW_RS13085	COG0640	Transcriptional regulator
BDW_RS13090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BDW_RS13100	COG3189	MarR family transcriptional regulator
BDW_RS13115	COG1733	regulation of RNA biosynthetic process
BDW_RS13120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BDW_RS13125	COG2832	Protein of unknown function (DUF454)
BDW_RS13150	COG0724	RNA recognition motif
BDW_RS13155	COG0702	epimerase
BDW_RS13200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BDW_RS13215	COG1335	isochorismatase
BDW_RS13245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BDW_RS13255	COG0538	isocitrate dehydrogenase activity
BDW_RS13265	COG2801	Transposase and inactivated derivatives
BDW_RS13280	COG0840	transmembrane signaling receptor activity
BDW_RS13285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BDW_RS13290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BDW_RS13295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BDW_RS13300	COG1100	Small GTP-binding protein
BDW_RS13305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BDW_RS13350	COG4191	Histidine kinase
BDW_RS13350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BDW_RS13355	COG0784	Response regulator, receiver
BDW_RS13355	COG2205	protein histidine kinase activity
BDW_RS13360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BDW_RS13365	COG0740	serine-type endopeptidase activity
BDW_RS13370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BDW_RS13375	COG0288	reversible hydration of carbon dioxide
BDW_RS13405	COG0544	peptidyl-prolyl cis-trans isomerase activity
BDW_RS13415	COG0793	Belongs to the peptidase S41A family
BDW_RS13425	COG2177	Part of the ABC transporter FtsEX involved in
BDW_RS13430	COG2884	Cell division ATP-binding protein ftsE
BDW_RS13445	COG1970	mechanosensitive ion channel activity
BDW_RS13460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BDW_RS13465	COG1132	(ABC) transporter
BDW_RS13510	COG1472	Belongs to the glycosyl hydrolase 3 family
BDW_RS13535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BDW_RS13545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BDW_RS13565	COG0052	Belongs to the universal ribosomal protein uS2 family
BDW_RS13570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BDW_RS13575	COG0528	UMP kinase activity
BDW_RS13580	COG0233	cytoplasmic translational termination
BDW_RS13585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BDW_RS13590	COG4589	Belongs to the CDS family
BDW_RS13600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BDW_RS13605	COG0489	protein tyrosine kinase activity
BDW_RS13615	COG0564	pseudouridine synthase activity
BDW_RS13620	COG1496	oxidoreductase activity
BDW_RS13700	COG0626	cystathionine gamma-synthase activity
BDW_RS13735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BDW_RS13745	COG1127	ABC transporter
BDW_RS13750	COG1127	ABC transporter
BDW_RS13755	COG0039	L-malate dehydrogenase activity
BDW_RS13760	COG0045	succinate-CoA ligase (ADP-forming) activity
BDW_RS13765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BDW_RS13770	COG1858	cytochrome C peroxidase
BDW_RS13780	COG0105	UTP biosynthetic process
BDW_RS13785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BDW_RS13820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BDW_RS13820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BDW_RS13840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BDW_RS13855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BDW_RS13865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BDW_RS13870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BDW_RS13875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BDW_RS13880	COG1530	ribonuclease E activity
BDW_RS13895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BDW_RS13905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BDW_RS13910	COG1404	Belongs to the peptidase S8 family
BDW_RS13915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BDW_RS13920	COG0439	Biotin carboxylase
BDW_RS13935	COG0805	protein transport
BDW_RS13950	COG0612	Peptidase, M16
BDW_RS13955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BDW_RS13960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BDW_RS13965	COG0484	heat shock protein binding
BDW_RS13985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BDW_RS14000	COG1007	ATP synthesis coupled electron transport
BDW_RS14015	COG0713	ATP synthesis coupled electron transport
BDW_RS14025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BDW_RS14030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BDW_RS14045	COG1472	Belongs to the glycosyl hydrolase 3 family
BDW_RS14050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BDW_RS14055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BDW_RS14060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BDW_RS14065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BDW_RS14070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BDW_RS14075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BDW_RS14090	COG1475	DNA binding
BDW_RS14095	COG1192	Involved in chromosome partitioning
BDW_RS14105	COG0357	Ribosomal RNA small subunit methyltransferase G
BDW_RS14110	COG0445	tRNA wobble uridine modification
BDW_RS14115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BDW_RS14125	COG0706	membrane insertase activity
BDW_RS14130	COG0594	ribonuclease P activity
BDW_RS14135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BDW_RS14155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BDW_RS14160	COG3420	alginic acid biosynthetic process
BDW_RS14175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BDW_RS14185	COG0840	transmembrane signaling receptor activity
BDW_RS14190	COG0739	heme binding
BDW_RS14225	COG3594	Acyltransferase
BDW_RS14280	COG2801	Transposase and inactivated derivatives
BDW_RS14295	COG2205	protein histidine kinase activity
BDW_RS14295	COG0784	Response regulator, receiver
BDW_RS14335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity