locus-tag	class	description
A11Q_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A11Q_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A11Q_RS00020	COG0187	DNA topoisomerase II activity
A11Q_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A11Q_RS00045	COG0356	it plays a direct role in the translocation of protons across the membrane
A11Q_RS00050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A11Q_RS00060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A11Q_RS00065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A11Q_RS00075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A11Q_RS00085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A11Q_RS00090	COG2086	electron transfer activity
A11Q_RS00100	COG1053	succinate dehydrogenase
A11Q_RS00115	COG0596	Alpha beta hydrolase
A11Q_RS00150	COG0360	Binds together with S18 to 16S ribosomal RNA
A11Q_RS00160	COG0359	binds to the 23S rRNA
A11Q_RS00240	COG0305	Participates in initiation and elongation during chromosome replication
A11Q_RS00250	COG0602	queuosine metabolic process
A11Q_RS00265	COG1674	ftsk spoiiie
A11Q_RS00285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A11Q_RS00290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A11Q_RS00295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A11Q_RS00300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A11Q_RS00340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A11Q_RS00345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A11Q_RS00350	COG0154	amidase activity
A11Q_RS00355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A11Q_RS00360	COG0248	Ppx GppA phosphatase
A11Q_RS00380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A11Q_RS00400	COG0702	epimerase
A11Q_RS00405	COG0254	rRNA binding
A11Q_RS00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A11Q_RS00415	COG2890	protein-(glutamine-N5) methyltransferase activity
A11Q_RS00420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A11Q_RS00440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A11Q_RS00500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A11Q_RS00540	COG2814	Major facilitator Superfamily
A11Q_RS00570	COG0071	Belongs to the small heat shock protein (HSP20) family
A11Q_RS00600	COG1741	Belongs to the pirin family
A11Q_RS00620	COG0564	pseudouridine synthase activity
A11Q_RS00625	COG0484	heat shock protein binding
A11Q_RS00630	COG1214	PFAM Peptidase M22, glycoprotease
A11Q_RS00645	COG4589	Belongs to the CDS family
A11Q_RS00650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A11Q_RS00655	COG0233	cytoplasmic translational termination
A11Q_RS00660	COG0528	UMP kinase activity
A11Q_RS00665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A11Q_RS00670	COG0052	Belongs to the universal ribosomal protein uS2 family
A11Q_RS00690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A11Q_RS00710	COG1472	Belongs to the glycosyl hydrolase 3 family
A11Q_RS00735	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A11Q_RS00740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A11Q_RS00760	COG1132	(ABC) transporter
A11Q_RS00765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A11Q_RS00780	COG3135	benzoate transporter
A11Q_RS00790	COG0625	glutathione transferase activity
A11Q_RS00795	COG4335	DNA alkylation repair
A11Q_RS00820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A11Q_RS00820	COG2111	Na H antiporter
A11Q_RS00830	COG1006	Multisubunit Na H antiporter MnhC subunit
A11Q_RS00835	COG0651	ATP synthesis coupled electron transport
A11Q_RS00840	COG1863	multisubunit Na H antiporter MnhE subunit
A11Q_RS00850	COG1320	monovalent cation:proton antiporter activity
A11Q_RS00875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A11Q_RS00885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A11Q_RS00890	COG0740	serine-type endopeptidase activity
A11Q_RS00895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A11Q_RS00915	COG2894	cell division
A11Q_RS00925	COG0544	peptidyl-prolyl cis-trans isomerase activity
A11Q_RS00930	COG0793	Belongs to the peptidase S41A family
A11Q_RS00945	COG2884	Cell division ATP-binding protein ftsE
A11Q_RS00960	COG1970	mechanosensitive ion channel activity
A11Q_RS00985	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A11Q_RS00990	COG1100	Small GTP-binding protein
A11Q_RS00995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A11Q_RS01000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A11Q_RS01005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A11Q_RS01015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A11Q_RS01160	COG2207	Transcriptional regulator
A11Q_RS01165	COG1028	Short-chain dehydrogenase reductase Sdr
A11Q_RS01180	COG0753	catalase activity
A11Q_RS01235	COG1061	Type III restriction enzyme res subunit
A11Q_RS01245	COG0475	glutathione-regulated potassium exporter activity
A11Q_RS01245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A11Q_RS01250	COG0513	Belongs to the DEAD box helicase family
A11Q_RS01255	COG2847	Copper chaperone PCu(A)C
A11Q_RS01280	COG0583	DNA-binding transcription factor activity
A11Q_RS01285	COG0445	tRNA wobble uridine modification
A11Q_RS01290	COG0242	peptide deformylase activity
A11Q_RS01305	COG1741	Belongs to the pirin family
A11Q_RS01315	COG2824	Alkylphosphonate utilization operon protein PhnA
A11Q_RS01350	COG0730	response to heat
A11Q_RS01370	COG1418	mRNA catabolic process
A11Q_RS01380	COG0488	(ABC) transporter
A11Q_RS01425	COG1940	carbohydrate kinase activity
A11Q_RS01465	COG0583	DNA-binding transcription factor activity
A11Q_RS01470	COG0702	epimerase
A11Q_RS01475	COG0778	Nitroreductase
A11Q_RS01480	COG0516	GMP reductase activity
A11Q_RS01480	COG0517	IMP dehydrogenase activity
A11Q_RS01485	COG0288	reversible hydration of carbon dioxide
A11Q_RS01525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A11Q_RS01535	COG2201	protein-glutamate methylesterase activity
A11Q_RS01550	COG2198	Histidine kinase
A11Q_RS01550	COG0784	Response regulator, receiver
A11Q_RS01550	COG0643	Histidine kinase
A11Q_RS01580	COG2354	Protein conserved in bacteria
A11Q_RS01615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A11Q_RS01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A11Q_RS01650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A11Q_RS01675	COG1253	flavin adenine dinucleotide binding
A11Q_RS01695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A11Q_RS01710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A11Q_RS01730	COG3012	SEC-C Motif Domain Protein
A11Q_RS01735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A11Q_RS01735	COG3008	intermembrane lipid transfer
A11Q_RS01740	COG2995	paraquat-inducible protein a
A11Q_RS01745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A11Q_RS01765	COG3568	Endonuclease Exonuclease Phosphatase
A11Q_RS01815	COG0783	Belongs to the Dps family
A11Q_RS01825	COG0427	acetyl-CoA hydrolase
A11Q_RS01870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A11Q_RS01880	COG1131	(ABC) transporter
A11Q_RS01925	COG2832	Protein of unknown function (DUF454)
A11Q_RS01930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A11Q_RS01945	COG3214	Protein conserved in bacteria
A11Q_RS01975	COG1077	Cell shape determining protein MreB Mrl
A11Q_RS01995	COG2003	Belongs to the UPF0758 family
A11Q_RS02030	COG2766	serine protein kinase
A11Q_RS02035	COG2718	Belongs to the UPF0229 family
A11Q_RS02040	COG2719	SpoVR family
A11Q_RS02045	COG0023	Translation Initiation Factor
A11Q_RS02050	COG0745	RESPONSE REGULATOR receiver
A11Q_RS02060	COG0590	tRNA wobble adenosine to inosine editing
A11Q_RS02065	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A11Q_RS02070	COG1610	YqeY-like protein
A11Q_RS02075	COG0358	DNA primase activity
A11Q_RS02090	COG3657	addiction module killer protein
A11Q_RS02110	COG4807	Protein conserved in bacteria
A11Q_RS02125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A11Q_RS02125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A11Q_RS02160	COG3706	GGDEF domain
A11Q_RS02165	COG1404	Belongs to the peptidase S8 family
A11Q_RS02195	COG0509	glycine decarboxylation via glycine cleavage system
A11Q_RS02205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A11Q_RS02210	COG0653	protein targeting
A11Q_RS02245	COG1845	cytochrome c oxidase, subunit III
A11Q_RS02255	COG0109	protoheme IX farnesyltransferase activity
A11Q_RS02280	COG0583	DNA-binding transcription factor activity
A11Q_RS02290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A11Q_RS02300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A11Q_RS02305	COG2866	Carboxypeptidase
A11Q_RS02315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A11Q_RS02325	COG0488	(ABC) transporter
A11Q_RS02330	COG0747	negative chemotaxis
A11Q_RS02335	COG0601	transmembrane transport
A11Q_RS02340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A11Q_RS02355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A11Q_RS02360	COG0538	isocitrate dehydrogenase activity
A11Q_RS02370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A11Q_RS02380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A11Q_RS02385	COG2119	membrane
A11Q_RS02395	COG2226	methyltransferase
A11Q_RS02400	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A11Q_RS02410	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A11Q_RS02415	COG0596	Alpha beta hydrolase
A11Q_RS02430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A11Q_RS02450	COG2945	thiolester hydrolase activity
A11Q_RS02450	COG0596	Alpha beta hydrolase
A11Q_RS02455	COG0513	Belongs to the DEAD box helicase family
A11Q_RS02485	COG1194	a g-specific adenine glycosylase
A11Q_RS02495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A11Q_RS02500	COG0583	DNA-binding transcription factor activity
A11Q_RS02505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A11Q_RS02510	COG0557	exoribonuclease II activity
A11Q_RS02550	COG1079	Belongs to the binding-protein-dependent transport system permease family
A11Q_RS02555	COG1079	Belongs to the binding-protein-dependent transport system permease family
A11Q_RS02560	COG3845	ABC transporter
A11Q_RS02565	COG1744	ABC transporter substrate-binding protein PnrA-like
A11Q_RS02575	COG1253	flavin adenine dinucleotide binding
A11Q_RS02580	COG4946	Tricorn protease homolog
A11Q_RS02580	COG0793	Belongs to the peptidase S41A family
A11Q_RS02585	COG1720	tRNA m6t6A37 methyltransferase activity
A11Q_RS02605	COG0525	valine-tRNA ligase activity
A11Q_RS02630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A11Q_RS02635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A11Q_RS02640	COG0424	maF-like protein
A11Q_RS02680	COG0811	peptide transport
A11Q_RS02705	COG1183	phosphatidylcholine synthase activity
A11Q_RS02710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A11Q_RS02720	COG0101	tRNA pseudouridine synthase activity
A11Q_RS02725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A11Q_RS02730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A11Q_RS02735	COG1396	sequence-specific DNA binding
A11Q_RS02750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A11Q_RS02765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A11Q_RS02770	COG1546	Belongs to the CinA family
A11Q_RS02770	COG1058	Belongs to the CinA family
A11Q_RS02775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A11Q_RS02780	COG0386	Belongs to the glutathione peroxidase family
A11Q_RS02800	COG1388	LysM domain
A11Q_RS02800	COG0741	lytic transglycosylase activity
A11Q_RS02805	COG4786	Flagellar basal body rod
A11Q_RS02815	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A11Q_RS02825	COG1706	bacterial-type flagellum-dependent cell motility
A11Q_RS02865	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A11Q_RS02870	COG1132	(ABC) transporter
A11Q_RS02885	COG1575	Belongs to the MenA family. Type 1 subfamily
A11Q_RS02915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A11Q_RS02930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A11Q_RS02955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A11Q_RS02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A11Q_RS02985	COG1509	lysine 2,3-aminomutase activity
A11Q_RS02990	COG0697	spore germination
A11Q_RS03000	COG0210	DNA helicase
A11Q_RS03040	COG1338	Plays a role in the flagellum-specific transport system
A11Q_RS03050	COG4791	protein targeting
A11Q_RS03055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A11Q_RS03060	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A11Q_RS03065	COG1419	protein localization to endoplasmic reticulum
A11Q_RS03090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A11Q_RS03105	COG2204	response regulator
A11Q_RS03115	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A11Q_RS03155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A11Q_RS03165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A11Q_RS03175	COG0038	chloride channel
A11Q_RS03180	COG0681	Belongs to the peptidase S26 family
A11Q_RS03250	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A11Q_RS03255	COG4191	Histidine kinase
A11Q_RS03285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A11Q_RS03290	COG2205	protein histidine kinase activity
A11Q_RS03310	COG0509	glycine decarboxylation via glycine cleavage system
A11Q_RS03315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A11Q_RS03330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A11Q_RS03330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A11Q_RS03350	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A11Q_RS03360	COG0776	regulation of translation
A11Q_RS03375	COG0494	nUDIX hydrolase
A11Q_RS03380	COG0167	dihydroorotate dehydrogenase activity
A11Q_RS03385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A11Q_RS03405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A11Q_RS03405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A11Q_RS03410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A11Q_RS03470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A11Q_RS03475	COG2030	dehydratase
A11Q_RS03485	COG0321	lipoyl(octanoyl) transferase activity
A11Q_RS03500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A11Q_RS03510	COG0018	arginyl-trna synthetase
A11Q_RS03520	COG0745	RESPONSE REGULATOR receiver
A11Q_RS03525	COG5002	protein histidine kinase activity
A11Q_RS03525	COG3850	Histidine kinase
A11Q_RS03530	COG1489	DNA binding
A11Q_RS03535	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A11Q_RS03535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A11Q_RS03565	COG0148	phosphopyruvate hydratase activity
A11Q_RS03590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A11Q_RS03590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A11Q_RS03610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A11Q_RS03615	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A11Q_RS03620	COG0504	CTP synthase activity
A11Q_RS03625	COG0517	IMP dehydrogenase activity
A11Q_RS03625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A11Q_RS03630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A11Q_RS03700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A11Q_RS03710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A11Q_RS03715	COG0481	GTPase activity
A11Q_RS03720	COG0681	Belongs to the peptidase S26 family
A11Q_RS03725	COG0681	Belongs to the peptidase S26 family
A11Q_RS03735	COG0540	Belongs to the ATCase OTCase family
A11Q_RS03740	COG0505	Belongs to the CarA family
A11Q_RS03750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A11Q_RS03760	COG1131	(ABC) transporter
A11Q_RS03770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A11Q_RS03875	COG1301	dicarboxylic acid transport
A11Q_RS03895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A11Q_RS03900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A11Q_RS03905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A11Q_RS03930	COG0116	Belongs to the methyltransferase superfamily
A11Q_RS03940	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A11Q_RS03950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A11Q_RS03955	COG2183	response to ionizing radiation
A11Q_RS03975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A11Q_RS03985	COG0793	Belongs to the peptidase S41A family
A11Q_RS04020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A11Q_RS04020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A11Q_RS04025	COG0285	dihydrofolate synthase activity
A11Q_RS04035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A11Q_RS04055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A11Q_RS04060	COG0514	ATP-dependent DNA helicase (RecQ)
A11Q_RS04065	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A11Q_RS04075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A11Q_RS04080	COG0248	Ppx GppA phosphatase
A11Q_RS04090	COG0745	RESPONSE REGULATOR receiver
A11Q_RS04095	COG5002	protein histidine kinase activity
A11Q_RS04160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A11Q_RS04165	COG0470	DNA polymerase III
A11Q_RS04170	COG0084	hydrolase, TatD family'
A11Q_RS04180	COG0126	phosphoglycerate kinase activity
A11Q_RS04185	COG0149	triose-phosphate isomerase activity
A11Q_RS04190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A11Q_RS04205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A11Q_RS04210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A11Q_RS04220	COG0616	signal peptide processing
A11Q_RS04250	COG0583	DNA-binding transcription factor activity
A11Q_RS04255	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A11Q_RS04270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A11Q_RS04275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A11Q_RS04285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A11Q_RS04285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A11Q_RS04300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A11Q_RS04310	COG0124	histidyl-tRNA synthetase
A11Q_RS04340	COG0513	Belongs to the DEAD box helicase family
A11Q_RS04350	COG0235	Class ii aldolase
A11Q_RS04360	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A11Q_RS04370	COG0747	negative chemotaxis
A11Q_RS04380	COG2088	sporulation resulting in formation of a cellular spore
A11Q_RS04390	COG4628	conserved protein (DUF2132)
A11Q_RS04400	COG1666	GTP binding
A11Q_RS04405	COG1272	protein, Hemolysin III
A11Q_RS04420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A11Q_RS04435	COG0714	Associated with various cellular activities
A11Q_RS04455	COG2304	oxidoreductase activity
A11Q_RS04475	COG0488	(ABC) transporter
A11Q_RS04480	COG0489	protein tyrosine kinase activity
A11Q_RS04490	COG0423	glycine-tRNA ligase activity
A11Q_RS04495	COG0574	Belongs to the PEP-utilizing enzyme family
A11Q_RS04495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A11Q_RS04510	COG0268	Binds directly to 16S ribosomal RNA
A11Q_RS04515	COG0728	peptidoglycan biosynthetic process
A11Q_RS04520	COG3384	dioxygenase
A11Q_RS04530	COG0583	DNA-binding transcription factor activity
A11Q_RS04540	COG3956	TIGRFAM MazG family protein
A11Q_RS04545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A11Q_RS04585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A11Q_RS04595	COG1136	(ABC) transporter
A11Q_RS04600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A11Q_RS04610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A11Q_RS04615	COG0673	inositol 2-dehydrogenase activity
A11Q_RS04620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A11Q_RS04625	COG1663	tetraacyldisaccharide 4'-kinase activity
A11Q_RS04645	COG2204	response regulator
A11Q_RS04650	COG5002	protein histidine kinase activity
A11Q_RS04655	COG0196	riboflavin kinase activity
A11Q_RS04665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A11Q_RS04675	COG1459	type II secretion system
A11Q_RS04690	COG0642	Histidine kinase
A11Q_RS04695	COG0745	RESPONSE REGULATOR receiver
A11Q_RS04705	COG0545	Peptidyl-prolyl cis-trans isomerase
A11Q_RS04710	COG0259	pyridoxamine-phosphate oxidase activity
A11Q_RS04720	COG2967	ApaG domain
A11Q_RS04730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A11Q_RS04750	COG1404	Belongs to the peptidase S8 family
A11Q_RS04755	COG2239	Acts as a magnesium transporter
A11Q_RS04760	COG1132	(ABC) transporter
A11Q_RS04765	COG1132	(ABC) transporter
A11Q_RS04775	COG0302	gtp cyclohydrolase
A11Q_RS04780	COG0308	aminopeptidase N
A11Q_RS04790	COG0450	alkyl hydroperoxide reductase
A11Q_RS04795	COG0598	Magnesium transport protein CorA
A11Q_RS04815	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A11Q_RS04820	COG2079	MmgE PrpD family protein
A11Q_RS04840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A11Q_RS04850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A11Q_RS04855	COG0632	four-way junction helicase activity
A11Q_RS04860	COG2255	four-way junction helicase activity
A11Q_RS04865	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A11Q_RS04870	COG0686	Belongs to the AlaDH PNT family
A11Q_RS04875	COG0658	competence protein
A11Q_RS04875	COG2333	competence protein COMEC
A11Q_RS04915	COG0772	Belongs to the SEDS family
A11Q_RS04920	COG0768	penicillin binding
A11Q_RS04935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A11Q_RS04940	COG0295	cytidine deaminase activity
A11Q_RS04945	COG0424	maF-like protein
A11Q_RS04950	COG0735	belongs to the Fur family
A11Q_RS04955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A11Q_RS04970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A11Q_RS04970	COG0543	2 iron, 2 sulfur cluster binding
A11Q_RS04980	COG3437	response regulator, receiver
A11Q_RS05005	COG0717	Belongs to the dCTP deaminase family
A11Q_RS05010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A11Q_RS05065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A11Q_RS05065	COG0116	Belongs to the methyltransferase superfamily
A11Q_RS05075	COG0564	pseudouridine synthase activity
A11Q_RS05090	COG0084	hydrolase, TatD family'
A11Q_RS05095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A11Q_RS05105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A11Q_RS05120	COG1830	Aldolase
A11Q_RS05125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A11Q_RS05135	COG3579	cysteine-type endopeptidase activity
A11Q_RS05145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A11Q_RS05150	COG0415	Belongs to the DNA photolyase family
A11Q_RS05155	COG1404	Belongs to the peptidase S8 family
A11Q_RS05160	COG1329	Transcriptional regulator
A11Q_RS05165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A11Q_RS05170	COG0215	cysteine-tRNA ligase activity
A11Q_RS05195	COG0556	nucleotide-excision repair
A11Q_RS05200	COG0322	excinuclease ABC activity
A11Q_RS05205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A11Q_RS05215	COG2385	sporulation resulting in formation of a cellular spore
A11Q_RS05230	COG4974	Belongs to the 'phage' integrase family
A11Q_RS05235	COG0606	chelatase, subunit chli
A11Q_RS05245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A11Q_RS05255	COG0514	ATP-dependent DNA helicase (RecQ)
A11Q_RS05270	COG1181	Belongs to the D-alanine--D-alanine ligase family
A11Q_RS05280	COG3590	peptidase
A11Q_RS05305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A11Q_RS05320	COG0539	negative regulation of cytoplasmic translation
A11Q_RS05360	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A11Q_RS05370	COG0318	PFAM AMP-dependent synthetase and ligase
A11Q_RS05380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A11Q_RS05390	COG0010	Belongs to the arginase family
A11Q_RS05400	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A11Q_RS05410	COG2197	response regulator
A11Q_RS05415	COG1607	acyl-coa hydrolase
A11Q_RS05420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A11Q_RS05430	COG0183	Belongs to the thiolase family
A11Q_RS05440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A11Q_RS05490	COG1250	3-hydroxyacyl-CoA dehydrogenase
A11Q_RS05495	COG1024	Enoyl-CoA hydratase
A11Q_RS05500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A11Q_RS05500	COG1703	isobutyryl-CoA mutase activity
A11Q_RS05500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A11Q_RS05515	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A11Q_RS05520	COG0688	phosphatidylethanolamine metabolic process
A11Q_RS05525	COG0720	synthase
A11Q_RS05555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A11Q_RS05560	COG0726	polysaccharide deacetylase
A11Q_RS05580	COG5001	Diguanylate cyclase
A11Q_RS05580	COG1716	ATPase activity
A11Q_RS05605	COG4651	solute:proton antiporter activity
A11Q_RS05605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A11Q_RS05650	COG4591	ABC-type transport system involved in lipoprotein release permease component
A11Q_RS05655	COG2171	N-acyltransferase activity
A11Q_RS05665	COG0019	diaminopimelate decarboxylase activity
A11Q_RS05675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A11Q_RS05680	COG0517	IMP dehydrogenase activity
A11Q_RS05680	COG0516	GMP reductase activity
A11Q_RS05695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A11Q_RS05705	COG0024	Methionine aminopeptidase
A11Q_RS05730	COG0724	RNA recognition motif
A11Q_RS05735	COG1047	Peptidyl-prolyl cis-trans
A11Q_RS05740	COG0724	RNA recognition motif
A11Q_RS05745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A11Q_RS05760	COG1959	2 iron, 2 sulfur cluster binding
A11Q_RS05790	COG1178	ABC-type Fe3 transport system permease component
A11Q_RS05840	COG1960	acyl-CoA dehydrogenase activity
A11Q_RS05875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A11Q_RS05880	COG4974	Belongs to the 'phage' integrase family
A11Q_RS05905	COG2801	Transposase and inactivated derivatives
A11Q_RS05930	COG2942	2-epimerase
A11Q_RS05965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A11Q_RS05965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A11Q_RS05975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A11Q_RS05975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A11Q_RS05990	COG1902	pentaerythritol trinitrate reductase activity
A11Q_RS05995	COG0708	Exodeoxyribonuclease III
A11Q_RS06045	COG1011	Hydrolase
A11Q_RS06060	COG0745	RESPONSE REGULATOR receiver
A11Q_RS06070	COG0643	Histidine kinase
A11Q_RS06070	COG2198	Histidine kinase
A11Q_RS06075	COG0835	chemotaxis
A11Q_RS06080	COG0840	transmembrane signaling receptor activity
A11Q_RS06090	COG2201	protein-glutamate methylesterase activity
A11Q_RS06095	COG0745	RESPONSE REGULATOR receiver
A11Q_RS06100	COG4191	Histidine kinase
A11Q_RS06100	COG0784	Response regulator, receiver
A11Q_RS06125	COG0739	heme binding
A11Q_RS06135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A11Q_RS06155	COG2010	Cytochrome c
A11Q_RS06170	COG2900	Belongs to the SlyX family
A11Q_RS06180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A11Q_RS06190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A11Q_RS06195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A11Q_RS06210	COG0180	Tryptophanyl-tRNA synthetase
A11Q_RS06250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A11Q_RS06265	COG0527	aspartate kinase activity
A11Q_RS06270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A11Q_RS06275	COG1054	Belongs to the UPF0176 family
A11Q_RS06280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A11Q_RS06285	COG1131	(ABC) transporter
A11Q_RS06290	COG0842	Transport permease protein
A11Q_RS06295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A11Q_RS06300	COG0228	four-way junction DNA binding
A11Q_RS06310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A11Q_RS06315	COG0336	Belongs to the RNA methyltransferase TrmD family
A11Q_RS06325	COG0335	large ribosomal subunit rRNA binding
A11Q_RS06330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A11Q_RS06395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A11Q_RS06400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A11Q_RS06405	COG0183	Belongs to the thiolase family
A11Q_RS06460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A11Q_RS06470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A11Q_RS06475	COG0517	IMP dehydrogenase activity
A11Q_RS06475	COG0516	GMP reductase activity
A11Q_RS06480	COG0519	Catalyzes the synthesis of GMP from XMP
A11Q_RS06480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A11Q_RS06530	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A11Q_RS06535	COG1012	belongs to the aldehyde dehydrogenase family
A11Q_RS06540	COG0037	tRNA processing
A11Q_RS06570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A11Q_RS06575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A11Q_RS06635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A11Q_RS06640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A11Q_RS06645	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A11Q_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
A11Q_RS06655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A11Q_RS06660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A11Q_RS06665	COG0698	ribose 5-phosphate isomerase
A11Q_RS06670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A11Q_RS06700	COG1242	4 iron, 4 sulfur cluster binding
A11Q_RS06710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A11Q_RS06725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A11Q_RS06730	COG1994	Peptidase M50
A11Q_RS06740	COG1960	acyl-CoA dehydrogenase activity
A11Q_RS06750	COG1187	pseudouridine synthase activity
A11Q_RS06760	COG0217	transcriptional regulatory protein
A11Q_RS06770	COG2166	iron-sulfur cluster assembly
A11Q_RS06795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A11Q_RS06800	COG2962	Rard protein
A11Q_RS06805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A11Q_RS06810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A11Q_RS06820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A11Q_RS06835	COG0733	neurotransmitter:sodium symporter activity
A11Q_RS06840	COG1160	GTP binding
A11Q_RS06855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A11Q_RS06860	COG0482	sulfurtransferase activity
A11Q_RS06865	COG1104	cysteine desulfurase activity
A11Q_RS06880	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A11Q_RS06885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A11Q_RS06900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A11Q_RS06910	COG1012	belongs to the aldehyde dehydrogenase family
A11Q_RS06930	COG1494	fructose-1,6-bisphosphatase
A11Q_RS06935	COG0824	Thioesterase
A11Q_RS06940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A11Q_RS06950	COG1418	mRNA catabolic process
A11Q_RS06965	COG1215	transferase activity, transferring glycosyl groups
A11Q_RS06995	COG1960	acyl-CoA dehydrogenase activity
A11Q_RS07005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A11Q_RS07020	COG0616	signal peptide processing
A11Q_RS07025	COG0444	Belongs to the ABC transporter superfamily
A11Q_RS07030	COG4608	Belongs to the ABC transporter superfamily
A11Q_RS07040	COG0601	transmembrane transport
A11Q_RS07050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A11Q_RS07055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A11Q_RS07060	COG0584	glycerophosphoryl diester phosphodiesterase
A11Q_RS07070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A11Q_RS07075	COG1090	epimerase
A11Q_RS07085	COG1612	heme a metabolic process
A11Q_RS07085	COG0109	protoheme IX farnesyltransferase activity
A11Q_RS07100	COG0494	nUDIX hydrolase
A11Q_RS07115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A11Q_RS07120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A11Q_RS07120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A11Q_RS07125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A11Q_RS07130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A11Q_RS07135	COG1862	Preprotein translocase
A11Q_RS07140	COG0343	queuine tRNA-ribosyltransferase activity
A11Q_RS07145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A11Q_RS07190	COG4221	oxidoreductase activity
A11Q_RS07215	COG0784	Response regulator, receiver
A11Q_RS07215	COG2205	protein histidine kinase activity
A11Q_RS07215	COG5002	protein histidine kinase activity
A11Q_RS07280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A11Q_RS07280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A11Q_RS07290	COG1720	tRNA m6t6A37 methyltransferase activity
A11Q_RS07295	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A11Q_RS07350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A11Q_RS07355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A11Q_RS07360	COG0438	transferase activity, transferring glycosyl groups
A11Q_RS07380	COG0463	Glycosyl transferase, family 2
A11Q_RS07390	COG2244	polysaccharide biosynthetic process
A11Q_RS07400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A11Q_RS07410	COG1088	dTDP-glucose 4,6-dehydratase activity
A11Q_RS07440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A11Q_RS07445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A11Q_RS07450	COG0581	inorganic phosphate transmembrane transporter activity
A11Q_RS07455	COG0573	inorganic phosphate transmembrane transporter activity
A11Q_RS07475	COG0776	regulation of translation
A11Q_RS07480	COG0072	phenylalanine-tRNA ligase activity
A11Q_RS07480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A11Q_RS07485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A11Q_RS07490	COG0357	Ribosomal RNA small subunit methyltransferase G
A11Q_RS07495	COG0357	Ribosomal RNA small subunit methyltransferase G
A11Q_RS07495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A11Q_RS07505	COG1216	Glycosyl transferase, family 2
A11Q_RS07530	COG1304	FMN binding
A11Q_RS07535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A11Q_RS07540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A11Q_RS07550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A11Q_RS07555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A11Q_RS07580	COG0437	4 iron, 4 sulfur cluster binding
A11Q_RS07590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A11Q_RS07590	COG1333	cytochrome c biogenesis protein
A11Q_RS07630	COG1450	Type ii and iii secretion system protein
A11Q_RS07635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A11Q_RS07640	COG1459	type II secretion system
A11Q_RS07685	COG0629	single-stranded DNA binding
A11Q_RS07710	COG1758	RNA polymerase activity
A11Q_RS07715	COG0194	GDP metabolic process
A11Q_RS07720	COG1561	YicC-like family, N-terminal region
A11Q_RS07725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A11Q_RS07730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A11Q_RS07755	COG0756	dUTP diphosphatase activity
A11Q_RS07760	COG0612	Peptidase, M16
A11Q_RS07765	COG1185	polyribonucleotide nucleotidyltransferase activity
A11Q_RS07770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A11Q_RS07775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A11Q_RS07780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A11Q_RS07785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A11Q_RS07795	COG0779	Required for maturation of 30S ribosomal subunits
A11Q_RS07865	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A11Q_RS07875	COG2270	Major facilitator Superfamily
A11Q_RS07880	COG1959	2 iron, 2 sulfur cluster binding
A11Q_RS07885	COG0564	pseudouridine synthase activity
A11Q_RS07890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A11Q_RS07910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A11Q_RS07930	COG1132	(ABC) transporter
A11Q_RS07965	COG4585	Histidine kinase
A11Q_RS07970	COG2197	response regulator
A11Q_RS07975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A11Q_RS07980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A11Q_RS08020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A11Q_RS08085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A11Q_RS08090	COG0024	Methionine aminopeptidase
A11Q_RS08115	COG0488	(ABC) transporter
A11Q_RS08165	COG4221	oxidoreductase activity
A11Q_RS08175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A11Q_RS08180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A11Q_RS08185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A11Q_RS08190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A11Q_RS08200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A11Q_RS08205	COG0443	Heat shock 70 kDa protein
A11Q_RS08210	COG0484	heat shock protein binding
A11Q_RS08220	COG4968	Prepilin-type N-terminal cleavage methylation domain
A11Q_RS08225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A11Q_RS08230	COG0542	response to heat
A11Q_RS08240	COG1404	Belongs to the peptidase S8 family
A11Q_RS08250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A11Q_RS08295	COG0473	3-isopropylmalate dehydrogenase activity
A11Q_RS08305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A11Q_RS08315	COG0179	Fumarylacetoacetate (FAA) hydrolase
A11Q_RS08320	COG1012	belongs to the aldehyde dehydrogenase family
A11Q_RS08385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A11Q_RS08390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A11Q_RS08395	COG0745	RESPONSE REGULATOR receiver
A11Q_RS08405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A11Q_RS08410	COG0181	hydroxymethylbilane synthase activity
A11Q_RS08420	COG0113	porphobilinogen synthase activity
A11Q_RS08435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A11Q_RS08470	COG0116	Belongs to the methyltransferase superfamily
A11Q_RS08470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A11Q_RS08480	COG1960	acyl-CoA dehydrogenase activity
A11Q_RS08485	COG1058	Belongs to the CinA family
A11Q_RS08485	COG1546	Belongs to the CinA family
A11Q_RS08510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A11Q_RS08515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A11Q_RS08520	COG0316	Belongs to the HesB IscA family
A11Q_RS08535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A11Q_RS08540	COG1418	mRNA catabolic process
A11Q_RS08560	COG0552	protein localization to endoplasmic reticulum
A11Q_RS08565	COG1196	nuclear chromosome segregation
A11Q_RS08570	COG1466	dna polymerase III delta subunit
A11Q_RS08580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A11Q_RS08585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A11Q_RS08590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A11Q_RS08625	COG2217	Heavy metal translocating P-type atpase
A11Q_RS08630	COG0513	Belongs to the DEAD box helicase family
A11Q_RS08650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A11Q_RS08655	COG1253	flavin adenine dinucleotide binding
A11Q_RS08660	COG3932	Exopolysaccharide synthesis, ExoD
A11Q_RS08705	COG0586	Pfam SNARE associated Golgi protein
A11Q_RS08710	COG2076	Multidrug Resistance protein
A11Q_RS08715	COG4558	Periplasmic binding protein
A11Q_RS08720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A11Q_RS08785	COG0572	uridine kinase
A11Q_RS08790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A11Q_RS08805	COG1012	belongs to the aldehyde dehydrogenase family
A11Q_RS08845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A11Q_RS08870	COG4942	peptidase
A11Q_RS08915	COG0166	Belongs to the GPI family
A11Q_RS08930	COG1252	NADH dehydrogenase
A11Q_RS08960	COG0488	(ABC) transporter
A11Q_RS08985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A11Q_RS09015	COG4191	Histidine kinase
A11Q_RS09025	COG1968	undecaprenyl-diphosphatase activity
A11Q_RS09030	COG0668	transmembrane transport
A11Q_RS09045	COG0860	N-Acetylmuramoyl-L-alanine amidase
A11Q_RS09050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A11Q_RS09055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A11Q_RS09060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A11Q_RS09065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A11Q_RS09070	COG0193	aminoacyl-tRNA hydrolase activity
A11Q_RS09075	COG0012	GTP binding
A11Q_RS09100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A11Q_RS09120	COG1228	amidohydrolase
A11Q_RS09125	COG0588	phosphoglycerate mutase activity
A11Q_RS09135	COG0508	dehydrogenase complex catalyzes the overall conversion of
A11Q_RS09150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A11Q_RS09160	COG2986	histidine ammonia-lyase
A11Q_RS09165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A11Q_RS09170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A11Q_RS09175	COG0242	peptide deformylase activity
A11Q_RS09185	COG0745	RESPONSE REGULATOR receiver
A11Q_RS09195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A11Q_RS09195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A11Q_RS09220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A11Q_RS09225	COG0583	DNA-binding transcription factor activity
A11Q_RS09260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A11Q_RS09265	COG0277	FAD linked oxidase domain protein
A11Q_RS09270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A11Q_RS09280	COG4589	Belongs to the CDS family
A11Q_RS09290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A11Q_RS09295	COG1295	ribonuclease BN
A11Q_RS09415	COG0668	transmembrane transport
A11Q_RS09440	COG0429	hydrolase of the alpha beta-hydrolase fold
A11Q_RS09445	COG3590	peptidase
A11Q_RS09455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A11Q_RS09485	COG0203	ribosomal protein L17
A11Q_RS09490	COG0202	RNA polymerase activity
A11Q_RS09495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A11Q_RS09500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A11Q_RS09505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A11Q_RS09510	COG0563	adenylate kinase activity
A11Q_RS09515	COG0201	protein transport
A11Q_RS09520	COG0200	Binds to the 23S rRNA
A11Q_RS09525	COG1841	ribosomal large subunit assembly
A11Q_RS09530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A11Q_RS09535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A11Q_RS09540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A11Q_RS09545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A11Q_RS09550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A11Q_RS09555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A11Q_RS09560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A11Q_RS09565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A11Q_RS09570	COG0255	Belongs to the universal ribosomal protein uL29 family
A11Q_RS09575	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A11Q_RS09580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A11Q_RS09585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A11Q_RS09590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A11Q_RS09595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A11Q_RS09600	COG0089	rRNA binding
A11Q_RS09605	COG0088	Forms part of the polypeptide exit tunnel
A11Q_RS09610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A11Q_RS09615	COG0051	transcription antitermination factor activity, RNA binding
A11Q_RS09620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A11Q_RS09625	COG0049	tRNA binding
A11Q_RS09630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A11Q_RS09635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A11Q_RS09640	COG0085	RNA polymerase activity
A11Q_RS09645	COG0222	ribosome binding
A11Q_RS09650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A11Q_RS09655	COG0081	regulation of translation
A11Q_RS09660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A11Q_RS09665	COG0250	Participates in transcription elongation, termination and antitermination
A11Q_RS09680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A11Q_RS09715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A11Q_RS09720	COG0284	orotidine-5'-phosphate decarboxylase activity
A11Q_RS09725	COG0442	prolyl-tRNA aminoacylation
A11Q_RS09730	COG2204	response regulator
A11Q_RS09735	COG5000	phosphorelay sensor kinase activity
A11Q_RS09750	COG0542	response to heat
A11Q_RS09760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A11Q_RS09770	COG2204	response regulator
A11Q_RS09775	COG4974	Belongs to the 'phage' integrase family
A11Q_RS09785	COG1381	Involved in DNA repair and RecF pathway recombination
A11Q_RS09805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A11Q_RS09810	COG1034	ATP synthesis coupled electron transport
A11Q_RS09820	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A11Q_RS09825	COG0649	NAD binding
A11Q_RS09825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A11Q_RS09830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A11Q_RS09845	COG0443	Heat shock 70 kDa protein
A11Q_RS09855	COG3639	organic phosphonate transmembrane transporter activity
A11Q_RS09860	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A11Q_RS09865	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A11Q_RS09875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A11Q_RS09880	COG1643	Atp-dependent helicase
A11Q_RS09915	COG2133	pyrroloquinoline quinone binding
A11Q_RS09920	COG1045	serine acetyltransferase
A11Q_RS09945	COG1127	ABC transporter
A11Q_RS09950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A11Q_RS09955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A11Q_RS09990	COG0328	RNA-DNA hybrid ribonuclease activity
A11Q_RS10065	COG0237	dephospho-CoA kinase activity
A11Q_RS10075	COG1022	Amp-dependent synthetase and ligase
A11Q_RS10085	COG0339	signal peptide processing
A11Q_RS10090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A11Q_RS10095	COG0497	DNA recombination
A11Q_RS10115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A11Q_RS10135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A11Q_RS10140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A11Q_RS10150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A11Q_RS10155	COG0772	Belongs to the SEDS family
A11Q_RS10160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A11Q_RS10165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A11Q_RS10170	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A11Q_RS10180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A11Q_RS10185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A11Q_RS10195	COG4555	ABC transporter
A11Q_RS10230	COG0768	penicillin binding
A11Q_RS10240	COG0275	rRNA processing
A11Q_RS10250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A11Q_RS10255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A11Q_RS10260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A11Q_RS10285	COG2027	D-alanyl-D-alanine carboxypeptidase
A11Q_RS10305	COG1360	Flagellar Motor Protein
A11Q_RS10310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A11Q_RS10320	COG1187	pseudouridine synthase activity
A11Q_RS10345	COG2264	protein methyltransferase activity
A11Q_RS10350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A11Q_RS10360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A11Q_RS10360	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A11Q_RS10385	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A11Q_RS10390	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A11Q_RS10400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A11Q_RS10405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A11Q_RS10410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A11Q_RS10450	COG0436	Aminotransferase
A11Q_RS10455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A11Q_RS10460	COG0742	ribosomal rna small subunit methyltransferase
A11Q_RS10465	COG0745	RESPONSE REGULATOR receiver
A11Q_RS10470	COG3852	Histidine kinase
A11Q_RS10475	COG3118	belongs to the thioredoxin family
A11Q_RS10475	COG0457	Tetratricopeptide repeat
A11Q_RS10485	COG1516	flagellar protein fliS
A11Q_RS10500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A11Q_RS10520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A11Q_RS10525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A11Q_RS10530	COG1178	ABC-type Fe3 transport system permease component
A11Q_RS10535	COG4143	(ABC) transporter
A11Q_RS10545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A11Q_RS10565	COG1181	Belongs to the D-alanine--D-alanine ligase family
A11Q_RS10595	COG0372	Belongs to the citrate synthase family
A11Q_RS10610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A11Q_RS10620	COG0142	geranyltranstransferase activity
A11Q_RS10635	COG5002	protein histidine kinase activity
A11Q_RS10645	COG5002	protein histidine kinase activity
A11Q_RS10660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A11Q_RS10665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A11Q_RS10670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A11Q_RS10680	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A11Q_RS10685	COG0531	amino acid
A11Q_RS10695	COG0205	6-phosphofructokinase activity
A11Q_RS10700	COG0683	leucine binding
A11Q_RS10715	COG0411	ABC transporter
A11Q_RS10750	COG0577	efflux transmembrane transporter activity
A11Q_RS10750	COG1136	(ABC) transporter
A11Q_RS10775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A11Q_RS10795	COG1157	protein secretion by the type III secretion system
A11Q_RS10805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A11Q_RS10810	COG1766	The M ring may be actively involved in energy transduction
A11Q_RS10815	COG1677	Flagellar hook-basal body complex protein FliE
A11Q_RS10830	COG2204	response regulator
A11Q_RS10845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A11Q_RS10865	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A11Q_RS10875	COG1435	thymidine kinase activity
A11Q_RS10880	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A11Q_RS10885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A11Q_RS10890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A11Q_RS10905	COG2204	response regulator
A11Q_RS10935	COG0010	Belongs to the arginase family
A11Q_RS10940	COG0512	Glutamine amidotransferase of anthranilate synthase
A11Q_RS10940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A11Q_RS10945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A11Q_RS10960	COG0009	L-threonylcarbamoyladenylate synthase
A11Q_RS10970	COG1136	(ABC) transporter
A11Q_RS10980	COG0724	RNA recognition motif
A11Q_RS10985	COG1047	Peptidyl-prolyl cis-trans
A11Q_RS11020	COG2223	nitrite transmembrane transporter activity
A11Q_RS11045	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A11Q_RS11050	COG0154	amidase activity
A11Q_RS11060	COG0667	Aldo Keto reductase
A11Q_RS11065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A11Q_RS11070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A11Q_RS11075	COG1078	dGTPase activity
A11Q_RS11090	COG1695	Transcriptional regulator
A11Q_RS11125	COG0183	Belongs to the thiolase family
A11Q_RS11135	COG0739	heme binding
A11Q_RS11140	COG0631	protein serine/threonine phosphatase activity
A11Q_RS11150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A11Q_RS11170	COG0300	oxidoreductase activity
A11Q_RS11180	COG0546	phosphoglycolate phosphatase activity
A11Q_RS11185	COG0444	Belongs to the ABC transporter superfamily
A11Q_RS11190	COG4608	Belongs to the ABC transporter superfamily
A11Q_RS11200	COG0745	RESPONSE REGULATOR receiver
A11Q_RS11210	COG2871	sodium ion transport
A11Q_RS11215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A11Q_RS11225	COG0495	leucyl-tRNA aminoacylation
A11Q_RS11230	COG1166	arginine decarboxylase activity
A11Q_RS11245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A11Q_RS11250	COG4174	ABC transporter (Permease)
A11Q_RS11260	COG0010	Belongs to the arginase family
A11Q_RS11290	COG0708	Exodeoxyribonuclease III
A11Q_RS11305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A11Q_RS11310	COG3186	Phenylalanine-4-hydroxylase
A11Q_RS11325	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A11Q_RS11355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A11Q_RS11360	COG1054	Belongs to the UPF0176 family
A11Q_RS11380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A11Q_RS11385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A11Q_RS11390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A11Q_RS11395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A11Q_RS11400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A11Q_RS11435	COG0439	Biotin carboxylase
A11Q_RS11440	COG1024	Enoyl-CoA hydratase
A11Q_RS11445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A11Q_RS11500	COG0778	Nitroreductase
A11Q_RS11515	COG5640	endopeptidase activity
A11Q_RS11530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A11Q_RS11530	COG0116	Belongs to the methyltransferase superfamily
A11Q_RS11535	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A11Q_RS11555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A11Q_RS11575	COG0006	proline dipeptidase activity
A11Q_RS11585	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A11Q_RS11590	COG0142	geranyltranstransferase activity
A11Q_RS11595	COG1722	exodeoxyribonuclease VII activity
A11Q_RS11600	COG1570	exodeoxyribonuclease VII activity
A11Q_RS11640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A11Q_RS11650	COG0396	ATPase activity
A11Q_RS11655	COG0719	Fe-S assembly protein
A11Q_RS11680	COG0811	peptide transport
A11Q_RS11695	COG0823	Involved in the tonB-independent uptake of proteins
A11Q_RS11705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A11Q_RS11710	COG0183	Belongs to the thiolase family
A11Q_RS11730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A11Q_RS11730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A11Q_RS11735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A11Q_RS11745	COG1217	gtp-binding protein TYPA
A11Q_RS11750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A11Q_RS11770	COG3100	YcgL domain-containing protein
A11Q_RS11820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A11Q_RS11860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A11Q_RS11865	COG1012	belongs to the aldehyde dehydrogenase family
A11Q_RS11875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A11Q_RS11880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A11Q_RS11890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A11Q_RS11895	COG3063	Type IV pilus biogenesis stability protein PilW
A11Q_RS11970	COG2201	protein-glutamate methylesterase activity
A11Q_RS11980	COG0459	protein refolding
A11Q_RS11985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A11Q_RS11990	COG5285	phytanoyl-CoA dioxygenase
A11Q_RS12005	COG1741	Belongs to the pirin family
A11Q_RS12010	COG0783	Belongs to the Dps family
A11Q_RS12035	COG0596	Alpha beta hydrolase
A11Q_RS12050	COG0069	glutamate synthase activity
A11Q_RS12065	COG2814	Major facilitator Superfamily
A11Q_RS12195	COG4221	oxidoreductase activity
A11Q_RS12195	COG0604	alcohol dehydrogenase
A11Q_RS12195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A11Q_RS12195	COG3321	synthase
A11Q_RS12200	COG2133	pyrroloquinoline quinone binding
A11Q_RS12215	COG3191	aminopeptidase activity
A11Q_RS12220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A11Q_RS12230	COG3550	peptidyl-serine autophosphorylation
A11Q_RS12260	COG1464	Belongs to the NlpA lipoprotein family
A11Q_RS12265	COG2011	ABC-type metal ion transport system permease component
A11Q_RS12270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A11Q_RS12315	COG0584	glycerophosphoryl diester phosphodiesterase
A11Q_RS12325	COG1177	transmembrane transport
A11Q_RS12330	COG3842	ATPase activity
A11Q_RS12465	COG0693	protein deglycase activity
A11Q_RS12480	COG1960	acyl-CoA dehydrogenase activity
A11Q_RS12515	COG1764	response to oxidative stress
A11Q_RS12540	COG0697	spore germination
A11Q_RS12550	COG1522	sequence-specific DNA binding
A11Q_RS12570	COG2192	nodulation
A11Q_RS12585	COG0626	cystathionine gamma-synthase activity
A11Q_RS12625	COG3153	acetyltransferase
A11Q_RS12625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A11Q_RS12640	COG0039	L-malate dehydrogenase activity
A11Q_RS12645	COG0045	succinate-CoA ligase (ADP-forming) activity
A11Q_RS12650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A11Q_RS12655	COG0105	UTP biosynthetic process
A11Q_RS12660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A11Q_RS12670	COG1426	Protein conserved in bacteria
A11Q_RS12690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A11Q_RS12700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A11Q_RS12700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A11Q_RS12720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A11Q_RS12735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A11Q_RS12740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A11Q_RS12745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A11Q_RS12750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A11Q_RS12755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A11Q_RS12815	COG4106	trans-aconitate 2-methyltransferase activity
A11Q_RS12850	COG0393	Putative heavy-metal-binding
A11Q_RS12870	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A11Q_RS12880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A11Q_RS12885	COG1404	Belongs to the peptidase S8 family
A11Q_RS12890	COG0017	Asparaginyl-tRNA synthetase
A11Q_RS12895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A11Q_RS12900	COG0439	Biotin carboxylase
A11Q_RS12905	COG0511	ligase activity, forming carbon-carbon bonds
A11Q_RS12905	COG5016	pyruvate
A11Q_RS12910	COG2259	Doxx family
A11Q_RS12915	COG0805	protein transport
A11Q_RS12920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A11Q_RS12945	COG0612	Peptidase, M16
A11Q_RS12950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A11Q_RS12955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A11Q_RS12960	COG0484	heat shock protein binding
A11Q_RS12980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A11Q_RS13060	COG1007	ATP synthesis coupled electron transport
A11Q_RS13070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A11Q_RS13075	COG0713	ATP synthesis coupled electron transport
A11Q_RS13085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A11Q_RS13090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A11Q_RS13110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A11Q_RS13115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A11Q_RS13120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A11Q_RS13125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A11Q_RS13150	COG1475	DNA binding
A11Q_RS13155	COG1192	Involved in chromosome partitioning
A11Q_RS13165	COG0357	Ribosomal RNA small subunit methyltransferase G
A11Q_RS13170	COG0445	tRNA wobble uridine modification
A11Q_RS13175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A11Q_RS13195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A11Q_RS13205	COG3118	belongs to the thioredoxin family
A11Q_RS13210	COG1714	RDD family
A11Q_RS13285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A11Q_RS13290	COG2885	chlorophyll binding
A11Q_RS13305	COG2264	protein methyltransferase activity
A11Q_RS13315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A11Q_RS13320	COG0617	tRNA 3'-terminal CCA addition
A11Q_RS13380	COG2885	chlorophyll binding
A11Q_RS13410	COG1408	metallophosphoesterase
A11Q_RS13415	COG3852	Histidine kinase
A11Q_RS13440	COG0617	tRNA 3'-terminal CCA addition
A11Q_RS13445	COG0741	lytic transglycosylase activity
A11Q_RS13475	COG1196	nuclear chromosome segregation
A11Q_RS13475	COG0739	heme binding
A11Q_RS13475	COG0741	lytic transglycosylase activity
A11Q_RS13485	COG0726	polysaccharide deacetylase
A11Q_RS13495	COG0840	transmembrane signaling receptor activity
A11Q_RS13505	COG0321	lipoyl(octanoyl) transferase activity
A11Q_RS13510	COG0739	heme binding
A11Q_RS13515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A11Q_RS13520	COG0802	atpase or kinase
A11Q_RS13540	COG4191	Histidine kinase
A11Q_RS13650	COG0784	Response regulator, receiver
A11Q_RS13650	COG5002	protein histidine kinase activity
A11Q_RS13660	COG1309	transcriptional regulator