locus-tag	class	description
HW988_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HW988_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HW988_RS00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HW988_RS00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HW988_RS00045	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
HW988_RS00050	ENOG41086BG	ATP synthase subunit C
HW988_RS00055	ENOG4107TXC	Transcriptional regulator
HW988_RS00060	ENOG4107QKV	phosphomannomutase
HW988_RS00065	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HW988_RS00070	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HW988_RS00080	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HW988_RS00090	ENOG4105C10	Electron transfer flavoprotein
HW988_RS00095	ENOG4105BZJ	Electron transfer flavoprotein
HW988_RS00130	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HW988_RS00140	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HW988_RS00150	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HW988_RS00165	ENOG4105E1F	short-chain dehydrogenase reductase
HW988_RS00170	ENOG4105CDU	Replicative dna helicase
HW988_RS00180	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HW988_RS00185	ENOG4105CNU	cell division protein FtsK
HW988_RS00205	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HW988_RS00210	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HW988_RS00215	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HW988_RS00225	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HW988_RS00240	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HW988_RS00255	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HW988_RS00260	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HW988_RS00265	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HW988_RS00270	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HW988_RS00275	ENOG4105D49	3-dehydroquinate synthase
HW988_RS00310	ENOG4105NRA	50s ribosomal protein l31 type b
HW988_RS00315	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HW988_RS00320	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HW988_RS00325	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HW988_RS00350	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HW988_RS00370	ENOG4105DQR	SNARE associated Golgi
HW988_RS00395	ENOG4107Y2X	deaminase
HW988_RS00405	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HW988_RS00410	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HW988_RS00425	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HW988_RS00430	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HW988_RS00490	ENOG4105CEY	Amp-dependent synthetase and ligase
HW988_RS00520	ENOG4105C19	ABC transporter
HW988_RS00575	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HW988_RS00580	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HW988_RS00595	ENOG4107YTP	response regulator receiver protein
HW988_RS00670	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS00675	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HW988_RS00685	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW988_RS00695	ENOG4105C8Y	Acetylornithine aminotransferase
HW988_RS00700	ENOG4105CWC	Acetylornithine deacetylase
HW988_RS00710	ENOG4105C26	Dehydrogenase
HW988_RS00715	ENOG4105HHA	aminodeoxychorismate lyase
HW988_RS00725	ENOG4105CFH	Aspartokinase
HW988_RS00735	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS00740	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HW988_RS00745	ENOG4105CI3	gtp-binding protein typa
HW988_RS00760	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HW988_RS00765	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HW988_RS00775	ENOG4105E14	MotA TolQ exbB proton channel
HW988_RS00780	ENOG4105ER2	Ompa motb domain protein
HW988_RS00805	ENOG41080RH	Thioredoxin
HW988_RS00820	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HW988_RS00825	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HW988_RS00835	ENOG4105SG9	biopolymer transport protein, ExbD
HW988_RS00840	ENOG4105E02	MotA TolQ exbB proton channel
HW988_RS00870	ENOG4105C9B	Cysteine desulfurase
HW988_RS00900	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HW988_RS00905	ENOG41084YM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HW988_RS00910	ENOG4105CTB	Polyprenyl synthetase
HW988_RS00925	ENOG4105DX0	Hemolysin A
HW988_RS00935	ENOG4107RAQ	aminopeptidase
HW988_RS00960	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HW988_RS00990	ENOG4105W5Q	DNA repair protein (RadC
HW988_RS01005	ENOG4108NVM	synthesis repressor PhaR
HW988_RS01015	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
HW988_RS01030	ENOG4105CYN	Serine protein kinase
HW988_RS01035	ENOG4106AKX	UPF0229 protein
HW988_RS01040	ENOG4105ED1	spovr family
HW988_RS01045	ENOG4108ZJT	translation initiation factor, Sui1
HW988_RS01050	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HW988_RS01080	ENOG4108Z6B	deaminase
HW988_RS01090	ENOG41084JP	30S ribosomal protein S21
HW988_RS01095	ENOG4105KTH	gatB Yqey
HW988_RS01100	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HW988_RS01105	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HW988_RS01120	ENOG4108S4H	thioesterase Superfamily protein
HW988_RS01175	ENOG4108C33	Resolvase
HW988_RS01225	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HW988_RS01265	ENOG4105DQ4	alcohol dehydrogenase
HW988_RS01270	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HW988_RS01290	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HW988_RS01300	ENOG4108YZA	Nitrogen regulatory protein pii
HW988_RS01315	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HW988_RS01345	ENOG4105CHR	reductase
HW988_RS01360	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
HW988_RS01365	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HW988_RS01370	ENOG4105CCU	oxidase (Subunit III)
HW988_RS01380	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HW988_RS01405	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HW988_RS01420	ENOG4105BZU	Histidine kinase
HW988_RS01430	ENOG4106ZX3	phosphonate ABC transporter, periplasmic phosphonate-binding protein
HW988_RS01440	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HW988_RS01465	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HW988_RS01475	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HW988_RS01485	ENOG4105CFI	type iii restriction protein res subunit
HW988_RS01515	ENOG4105JQZ	Methyltransferase
HW988_RS01530	ENOG4105EA8	2-Nitropropane dioxygenase
HW988_RS01555	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HW988_RS01565	ENOG4105K89	arsenate reductase
HW988_RS01675	ENOG4105C1J	atp-dependent rna helicase
HW988_RS01685	ENOG4105HMI	Membrane
HW988_RS01690	ENOG4105CV8	reductase
HW988_RS01700	ENOG41065KQ	synthase
HW988_RS01705	ENOG4105EYM	Major Facilitator superfamily
HW988_RS01720	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HW988_RS01725	ENOG4108VPT	UPF0234 protein
HW988_RS01730	ENOG4105VFU	Rna-binding protein
HW988_RS01735	ENOG4108UJV	acyl-CoA thioesterase i
HW988_RS01740	ENOG4108I0Y	(ABC) transporter
HW988_RS01750	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HW988_RS01765	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HW988_RS01775	ENOG4105KUZ	arsenate reductase
HW988_RS01780	ENOG4105CYW	agmatinase
HW988_RS01790	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HW988_RS01795	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HW988_RS01810	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HW988_RS01815	ENOG4105C8T	Leucyl-tRNA synthetase
HW988_RS01830	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HW988_RS01840	ENOG4105C3M	thioredoxin reductase
HW988_RS01845	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HW988_RS01875	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HW988_RS01900	ENOG4105C0B	DNA polymerase III (alpha subunit)
HW988_RS01945	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HW988_RS01990	ENOG4105DR5	peptidase
HW988_RS02010	ENOG4105CHU	acetyl-coa acetyltransferase
HW988_RS02040	ENOG4105I03	Flagellin
HW988_RS02045	ENOG4105I03	Flagellin
HW988_RS02060	ENOG4105C5Q	Transcriptional regulator
HW988_RS02065	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HW988_RS02070	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HW988_RS02090	ENOG4105UT3	Methyl-accepting chemotaxis
HW988_RS02105	ENOG4105UIB	(ABC) transporter
HW988_RS02110	ENOG4108JQ9	ABC transporter
HW988_RS02115	ENOG4105DIH	basic membrane
HW988_RS02120	ENOG4107RU9	Transcriptional regulator, Crp Fnr family
HW988_RS02125	ENOG4108R96	Methyltransferase, YaeB family
HW988_RS02140	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HW988_RS02165	ENOG4105VZ9	UPF0235 protein
HW988_RS02175	ENOG4105II7	pyrroline-5-carboxylate reductase
HW988_RS02180	ENOG4105DFA	alanine racemase domain protein
HW988_RS02195	ENOG4108Z03	MAF-like protein
HW988_RS02220	ENOG4108UW8	fha domain-containing protein
HW988_RS02235	ENOG4105E02	MotA TolQ exbB proton channel
HW988_RS02240	ENOG4105SG9	biopolymer transport protein, ExbD
HW988_RS02265	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HW988_RS02270	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HW988_RS02290	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
HW988_RS02295	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HW988_RS02300	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HW988_RS02305	ENOG4108UJD	30S ribosomal protein S9
HW988_RS02320	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS02345	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HW988_RS02355	ENOG4107RN3	metallophosphoesterase
HW988_RS02360	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HW988_RS02370	ENOG4108ZAI	phosphatidylglycerophosphatase a
HW988_RS02375	ENOG4105CEV	competence damage-inducible protein
HW988_RS02380	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HW988_RS02420	ENOG4108V06	Glutathione peroxidase
HW988_RS02445	ENOG4108JQA	flagellar
HW988_RS02450	ENOG4105CGA	flagellar basal-body rod protein FlgG
HW988_RS02465	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HW988_RS02485	ENOG4105E1Q	flagellar hook-associated protein
HW988_RS02490	ENOG4105DTJ	flagellar hook-associated protein
HW988_RS02495	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HW988_RS02500	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
HW988_RS02515	ENOG4105CGY	Dna recombination protein
HW988_RS02520	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HW988_RS02530	ENOG4105CEY	Amp-dependent synthetase and ligase
HW988_RS02550	ENOG4105WGP	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity)
HW988_RS02555	ENOG4105EAH	synthase
HW988_RS02565	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
HW988_RS02600	ENOG4105BZN	citrate synthase
HW988_RS02615	ENOG4107ZUX	Histidine triad (HIT) protein
HW988_RS02645	ENOG4105CBS	Chea signal transduction histidine kinase
HW988_RS02655	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HW988_RS02665	ENOG4105CPF	Cell wall formation (By similarity)
HW988_RS02670	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HW988_RS02710	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HW988_RS02725	ENOG4105I03	Flagellin
HW988_RS02735	ENOG4105I03	Flagellin
HW988_RS02750	ENOG4105MQ3	flagellar protein FliS
HW988_RS02785	ENOG4105BZU	Histidine kinase
HW988_RS02795	ENOG4106H78	methyltransferase
HW988_RS02800	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HW988_RS02840	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
HW988_RS02850	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HW988_RS02865	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HW988_RS02880	ENOG4105DR4	Methyltransferase
HW988_RS02890	ENOG4105BZU	Histidine kinase
HW988_RS02900	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HW988_RS02920	ENOG4105EMU	Dehydrogenase
HW988_RS02940	ENOG4108ZJ4	polysaccharide deacetylase
HW988_RS02970	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HW988_RS02985	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HW988_RS03010	ENOG4108594	Permease of the drug metabolite transporter
HW988_RS03015	ENOG4105FE9	pseudouridine synthase
HW988_RS03055	ENOG4107RD7	Flagellar Motor Protein, MotA
HW988_RS03060	ENOG4105ER2	Ompa motb domain protein
HW988_RS03070	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HW988_RS03075	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HW988_RS03080	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HW988_RS03090	ENOG4105E4C	Lytic transglycosylase catalytic
HW988_RS03110	ENOG4105D4A	Cell wall formation (By similarity)
HW988_RS03125	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HW988_RS03145	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HW988_RS03155	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HW988_RS03160	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HW988_RS03170	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HW988_RS03180	ENOG4105CJN	penicillin-binding protein
HW988_RS03200	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HW988_RS03205	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HW988_RS03225	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HW988_RS03230	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HW988_RS03245	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HW988_RS03250	ENOG4105DFU	Cell wall formation (By similarity)
HW988_RS03275	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS03280	ENOG410812A	polypeptide-transport-associated domain protein, FtsQ-type
HW988_RS03285	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HW988_RS03290	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HW988_RS03295	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HW988_RS03315	ENOG4107QM5	aconitate hydratase
HW988_RS03370	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HW988_RS03375	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HW988_RS03380	ENOG4105DGW	oligopeptidase A
HW988_RS03405	ENOG4105C1G	acyl-Coa dehydrogenase
HW988_RS03410	ENOG4108IQE	Amp-dependent synthetase and ligase
HW988_RS03415	ENOG4106PBJ	Serine threonine-protein kinase Pkn6
HW988_RS03420	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HW988_RS03465	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HW988_RS03470	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HW988_RS03475	ENOG4108W6C	Dehydrogenase
HW988_RS03490	ENOG4108IYU	L-aspartate oxidase
HW988_RS03495	ENOG4105I8F	Histidine kinase
HW988_RS03505	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HW988_RS03515	ENOG4105DHJ	ABC, transporter
HW988_RS03520	ENOG4107KIA	Virulence factor Mce family protein
HW988_RS03540	ENOG4105D7W	serine acetyltransferase
HW988_RS03555	ENOG4105JUU	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HW988_RS03570	ENOG4105CQ7	ATP-dependent helicase
HW988_RS03575	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HW988_RS03590	ENOG4105D5T	phosphonate abc transporter
HW988_RS03615	ENOG4105BZ1	(ABC) transporter
HW988_RS03620	ENOG4105BZ1	(ABC) transporter
HW988_RS03670	ENOG4105E18	UPF0276 protein
HW988_RS03675	ENOG4108YYC	ycei family
HW988_RS03685	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HW988_RS03690	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HW988_RS03695	ENOG4105GKE	subunit e
HW988_RS03705	ENOG4108IEH	NADH dehydrogenase subunit g
HW988_RS03710	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HW988_RS03730	ENOG4105DU1	integral membrane protein, terc
HW988_RS03735	ENOG41063Z6	transcriptional regulator, lysR family
HW988_RS03765	ENOG410826D	Involved in DNA repair and RecF pathway recombination (By similarity)
HW988_RS03770	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HW988_RS03775	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS03795	ENOG4105I03	Flagellin
HW988_RS03810	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HW988_RS03825	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS03835	ENOG4108R6K	riboflavin synthase, subunit alpha
HW988_RS03840	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HW988_RS03845	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HW988_RS03850	ENOG4105ES5	Histidine kinase
HW988_RS03855	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS03860	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HW988_RS03870	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HW988_RS03875	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HW988_RS03900	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HW988_RS03915	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HW988_RS03920	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HW988_RS03925	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HW988_RS03930	ENOG4108VZM	50s ribosomal protein L10
HW988_RS03935	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HW988_RS03940	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HW988_RS03945	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HW988_RS03950	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HW988_RS03955	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HW988_RS03960	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HW988_RS03965	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HW988_RS03970	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HW988_RS03975	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HW988_RS03980	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HW988_RS03985	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW988_RS03990	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HW988_RS03995	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HW988_RS04000	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HW988_RS04005	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HW988_RS04015	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HW988_RS04020	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HW988_RS04025	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HW988_RS04030	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HW988_RS04035	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HW988_RS04040	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HW988_RS04045	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HW988_RS04050	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HW988_RS04060	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HW988_RS04065	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HW988_RS04070	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HW988_RS04075	ENOG41067V7	50S ribosomal protein L36
HW988_RS04080	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW988_RS04085	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HW988_RS04090	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HW988_RS04095	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HW988_RS04100	ENOG4108ZT0	50S ribosomal protein l17
HW988_RS04105	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW988_RS04115	ENOG4105BZU	Histidine kinase
HW988_RS04130	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HW988_RS04140	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HW988_RS04165	ENOG4105CSU	acyl-Coa dehydrogenase
HW988_RS04185	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS04210	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HW988_RS04220	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HW988_RS04245	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HW988_RS04250	ENOG4105DQE	DNA ligase
HW988_RS04260	ENOG4105CYC	Transferase
HW988_RS04265	ENOG410851E	CsbD-like
HW988_RS04280	ENOG4105F1S	paraquat-inducible protein a
HW988_RS04285	ENOG4107JEE	Short-chain dehydrogenase reductase Sdr
HW988_RS04355	ENOG4105CPK	Glycosyl transferase (Group 1
HW988_RS04375	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HW988_RS04395	ENOG4107S2Z	UPF0761 membrane protein
HW988_RS04405	ENOG4105C8F	Beta-lactamase domain protein
HW988_RS04415	ENOG4108HPI	phosphatidate Cytidylyltransferase
HW988_RS04420	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS04425	ENOG4108JQ1	Dehydrogenase
HW988_RS04445	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HW988_RS04450	ENOG4105CQB	FAD linked oxidase domain protein
HW988_RS04470	ENOG4105E0M	Sulfatase
HW988_RS04540	ENOG4108IJ0	Aspartate ammonia-lyase
HW988_RS04565	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HW988_RS04575	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HW988_RS04640	ENOG4105BZU	Histidine kinase
HW988_RS04645	ENOG4105BZU	Histidine kinase
HW988_RS04700	ENOG4107SC1	transglycosylase
HW988_RS04705	ENOG4107SDU	Methyl-accepting chemotaxis
HW988_RS04710	ENOG4105BZU	Histidine kinase
HW988_RS04715	ENOG4108V3W	Chemotaxis protein, CheW
HW988_RS04750	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HW988_RS04775	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HW988_RS04780	ENOG4105D6U	Sodium Glutamate Symporter
HW988_RS04825	ENOG4105BZU	Histidine kinase
HW988_RS04830	ENOG4105BZU	Histidine kinase
HW988_RS04835	ENOG4105BZU	Histidine kinase
HW988_RS04855	ENOG4108W2Y	isochorismatase
HW988_RS04860	ENOG4105DR9	pseudouridine synthase
HW988_RS04885	ENOG4105Q26	Siderophore-interacting protein
HW988_RS04895	ENOG4108W2P	Methyl-accepting chemotaxis
HW988_RS04925	ENOG4105DIN	metallophosphoesterase
HW988_RS04960	ENOG410642W	LysR family Transcriptional regulator
HW988_RS04965	ENOG4105DQ4	alcohol dehydrogenase
HW988_RS04970	ENOG4107SET	aldo keto reductase
HW988_RS04980	ENOG4108UPT	UPF0178 protein
HW988_RS05025	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HW988_RS05035	ENOG4107QJE	Chromosome Partitioning Protein
HW988_RS05075	ENOG4105BZU	Histidine kinase
HW988_RS05085	ENOG4108JUA	Transcriptional regulator
HW988_RS05090	ENOG4105VN1	Heat shock protein
HW988_RS05105	ENOG4105CY0	Metallo-Beta-Lactamase
HW988_RS05135	ENOG4105QNF	Outer membrane lipoprotein
HW988_RS05140	ENOG4105QNF	Outer membrane lipoprotein
HW988_RS05160	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HW988_RS05165	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HW988_RS05200	ENOG4105BZU	Histidine kinase
HW988_RS05215	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HW988_RS05220	ENOG4105HEI	LysR family (Transcriptional regulator
HW988_RS05240	ENOG4107VAM	peptidase, m28
HW988_RS05255	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HW988_RS05275	ENOG4105K4W	Could be involved in septation (By similarity)
HW988_RS05285	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS05300	ENOG4105C0H	protease
HW988_RS05310	ENOG4105D0M	Protease HtpX homolog
HW988_RS05315	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HW988_RS05380	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HW988_RS05385	ENOG4107QM5	aconitate hydratase
HW988_RS05405	ENOG4105WD1	Membrane
HW988_RS05420	ENOG4105PNM	synthesis protein
HW988_RS05460	ENOG4105UYK	outer membrane protein a
HW988_RS05480	ENOG4105EE5	Membrane protein terC
HW988_RS05510	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS05525	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HW988_RS05530	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HW988_RS05545	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HW988_RS05550	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HW988_RS05565	ENOG4105M6F	mutator MutT protein
HW988_RS05600	ENOG4105CGP	Urocanate hydratase
HW988_RS05610	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
HW988_RS05705	ENOG4107QN2	dihydrolipoyl dehydrogenase
HW988_RS05710	ENOG4105K7K	Transcriptional regulator
HW988_RS05730	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
HW988_RS05740	ENOG4105CR8	Transcriptional regulator
HW988_RS05755	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HW988_RS05760	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HW988_RS05765	ENOG4107Y70	Heat shock protein
HW988_RS05780	ENOG4108UW5	maltose o-acetyltransferase
HW988_RS05785	ENOG4105CI2	imidazolone-5-propionate hydrolase
HW988_RS05805	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HW988_RS05815	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HW988_RS05825	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HW988_RS05830	ENOG4107SC1	transglycosylase
HW988_RS05835	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HW988_RS05840	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HW988_RS05855	ENOG4105C3G	gtp-binding protein
HW988_RS05860	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HW988_RS05865	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HW988_RS05870	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HW988_RS05880	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HW988_RS05885	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HW988_RS05890	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HW988_RS05905	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HW988_RS05910	ENOG4105D64	Mechanosensitive ion channel
HW988_RS05915	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HW988_RS05930	ENOG4105E39	Enoyl-CoA hydratase
HW988_RS05945	ENOG4107835	probably involved in intracellular septation (By similarity)
HW988_RS05950	ENOG4105CD3	dihydroorotase
HW988_RS05970	ENOG4105MGM	doxx family
HW988_RS06000	ENOG4105KNA	-acetyltransferase
HW988_RS06060	ENOG4105F27	Major Facilitator
HW988_RS06065	ENOG4105NAE	bifunctional deaminase-reductase domain protein
HW988_RS06090	ENOG4108M3P	Membrane
HW988_RS06100	ENOG4105T0Z	Conserved Protein
HW988_RS06185	ENOG4105DEN	Luciferase family
HW988_RS06190	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HW988_RS06215	ENOG4105EQK	-acetyltransferase
HW988_RS06240	ENOG4105CFG	Acts as a chaperone (By similarity)
HW988_RS06245	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HW988_RS06255	ENOG4105KHC	sulfurtransferase
HW988_RS06270	ENOG4108VCT	Sulfite exporter TauE/SafE
HW988_RS06275	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HW988_RS06325	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HW988_RS06335	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HW988_RS06340	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HW988_RS06350	ENOG4105K5B	UPF0225 protein
HW988_RS06355	ENOG4105EMU	Dehydrogenase
HW988_RS06360	ENOG4105C9Q	fumarate hydratase class II
HW988_RS06380	ENOG4105DR9	pseudouridine synthase
HW988_RS06410	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
HW988_RS06420	ENOG4105C5H	ABC transporter
HW988_RS06425	ENOG4105BZU	Histidine kinase
HW988_RS06445	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HW988_RS06475	ENOG410851E	CsbD-like
HW988_RS06495	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HW988_RS06500	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HW988_RS06525	ENOG4105N1N	Cupin superfamily protein
HW988_RS06535	ENOG4108V06	Glutathione peroxidase
HW988_RS06560	ENOG4105BZU	Histidine kinase
HW988_RS06575	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HW988_RS06595	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HW988_RS06600	ENOG4106PBJ	Serine threonine-protein kinase Pkn6
HW988_RS06615	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HW988_RS06635	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
HW988_RS06660	ENOG4106R7G	Glycoside hydrolase family 5
HW988_RS06665	ENOG4105E0X	reductase
HW988_RS06685	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS06720	ENOG4105DR4	Methyltransferase
HW988_RS06730	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS06735	ENOG4105CFP	Peptidase U32
HW988_RS06745	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS06750	ENOG4105C1J	atp-dependent rna helicase
HW988_RS06770	ENOG4105NXH	GreA GreB family elongation factor
HW988_RS06785	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HW988_RS06810	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
HW988_RS06830	ENOG4106R7G	Glycoside hydrolase family 5
HW988_RS06860	ENOG4107R1I	NAD-dependent malic enzyme
HW988_RS06870	ENOG4105C28	cystathionine
HW988_RS06880	ENOG4105EUZ	Beta-lactamase domain protein
HW988_RS06890	ENOG4105C1J	atp-dependent rna helicase
HW988_RS06905	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HW988_RS06965	ENOG4105C1J	atp-dependent rna helicase
HW988_RS06970	ENOG4105C5H	ABC transporter
HW988_RS06985	ENOG4105DEU	major facilitator superfamily
HW988_RS06995	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HW988_RS07000	ENOG4105D3G	Pseudouridine synthase
HW988_RS07025	ENOG4105EST	Metal Dependent Phosphohydrolase
HW988_RS07065	ENOG4105CSR	polyphosphate kinase 2
HW988_RS07070	ENOG4108Z9K	Osmotically inducible protein
HW988_RS07080	ENOG4105BZU	Histidine kinase
HW988_RS07105	ENOG4105BZU	Histidine kinase
HW988_RS07110	ENOG4105BZU	Histidine kinase
HW988_RS07120	ENOG4105CPN	adenine deaminase
HW988_RS07135	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HW988_RS07165	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HW988_RS07170	ENOG4108JQ1	Dehydrogenase
HW988_RS07175	ENOG4105C5R	Aminotransferase
HW988_RS07185	ENOG4105TQK	DNA polymerase iii, delta' subunit
HW988_RS07205	ENOG41082GE	Binds directly to 16S ribosomal RNA (By similarity)
HW988_RS07210	ENOG4105CJR	Integral membrane protein (MviN
HW988_RS07215	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS07220	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS07225	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS07290	ENOG4105DXN	mazG family
HW988_RS07300	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HW988_RS07315	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HW988_RS07325	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW988_RS07335	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HW988_RS07350	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HW988_RS07355	ENOG4105D1S	lipid A biosynthesis
HW988_RS07380	ENOG4105DKP	glycosyl transferase, family 9
HW988_RS07385	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS07390	ENOG4105BZU	Histidine kinase
HW988_RS07395	ENOG4105DTN	riboflavin biosynthesis protein ribF
HW988_RS07405	ENOG4107QHF	type ii secretion system protein e
HW988_RS07420	ENOG4105BZU	Histidine kinase
HW988_RS07425	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS07480	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HW988_RS07495	ENOG4105DR9	pseudouridine synthase
HW988_RS07580	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HW988_RS07585	ENOG4105CHV	Transcription elongation factor NusA
HW988_RS07590	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HW988_RS07595	ENOG41082KD	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HW988_RS07600	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HW988_RS07605	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HW988_RS07610	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HW988_RS07615	ENOG4105C1V	Peptidase, M16
HW988_RS07620	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HW988_RS07650	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HW988_RS07665	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HW988_RS07670	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HW988_RS07675	ENOG4105DSJ	YicC domain protein
HW988_RS07680	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HW988_RS07685	ENOG41084BP	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HW988_RS07690	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HW988_RS07695	ENOG4105BZU	Histidine kinase
HW988_RS07715	ENOG4108UUM	single-stranded DNA-binding protein
HW988_RS07760	ENOG4105D7Q	type ii secretion system
HW988_RS07765	ENOG4107QHF	type ii secretion system protein e
HW988_RS07805	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HW988_RS07810	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HW988_RS07820	ENOG4107QNG	Phosphoribosylglycinamide synthetase
HW988_RS07825	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HW988_RS07830	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HW988_RS07835	ENOG4108DGI	Phosphoribosylformylglycinamidine synthase I
HW988_RS07840	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HW988_RS07845	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HW988_RS07880	ENOG4108WBT	adenosyltransferase
HW988_RS07890	ENOG4105CRE	cytochrome C
HW988_RS07895	ENOG4105CRE	cytochrome C
HW988_RS07905	ENOG4107SFQ	iron-sulfur binding
HW988_RS07945	ENOG4105C22	threonyL-tRNA synthetase
HW988_RS07950	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HW988_RS07975	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HW988_RS08000	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HW988_RS08005	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HW988_RS08040	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HW988_RS08075	ENOG4108JEZ	rRNA small subunit methyltransferase G
HW988_RS08080	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HW988_RS08085	ENOG4105CRW	Short chain fatty acid transporter
HW988_RS08095	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HW988_RS08100	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HW988_RS08105	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HW988_RS08170	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HW988_RS08190	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HW988_RS08195	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HW988_RS08205	ENOG4105DDI	hemolysin-type calcium-binding region
HW988_RS08245	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HW988_RS08250	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HW988_RS08255	ENOG4105VIE	preprotein translocase, subunit YajC
HW988_RS08260	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HW988_RS08265	ENOG4108JIS	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HW988_RS08270	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HW988_RS08275	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HW988_RS08310	ENOG4105EAM	Na Pi-cotransporter
HW988_RS08325	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HW988_RS08330	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HW988_RS08335	ENOG4105PGM	cation diffusion facilitator family transporter
HW988_RS08390	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HW988_RS08405	ENOG4105CPN	adenine deaminase
HW988_RS08415	ENOG4105C7W	Xanthine dehydrogenase
HW988_RS08435	ENOG4105I3K	Ferric uptake regulator, Fur family
HW988_RS08460	ENOG4105C8U	phosphate abc transporter
HW988_RS08465	ENOG4105E2Z	phosphate ABC transporter (Permease
HW988_RS08470	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HW988_RS08490	ENOG410802X	bacteriophage n4 adsorption protein b
HW988_RS08505	ENOG4105FAW	cDP-glucose 4,6-dehydratase
HW988_RS08515	ENOG4105CKK	Glycosyl transferase, family 2
HW988_RS08520	ENOG4105EXC	Acyl-transferase
HW988_RS08540	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HW988_RS08555	ENOG4105CG5	Glycosyl transferase (Group 1
HW988_RS08580	ENOG4105IQ5	FAD linked oxidase domain protein
HW988_RS08600	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HW988_RS08640	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HW988_RS08665	ENOG4105EXC	Acyl-transferase
HW988_RS08675	ENOG4105C5E	polysaccharide biosynthesis protein
HW988_RS08680	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HW988_RS08700	ENOG4105ESV	Glycosyl transferase, family 4
HW988_RS08730	ENOG4105C6T	cysteine synthase
HW988_RS08735	ENOG4107NA1	Endonuclease Exonuclease phosphatase
HW988_RS08775	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HW988_RS08785	ENOG4108TPP	exopolysaccharide synthesis
HW988_RS08795	ENOG4108R96	Methyltransferase, YaeB family
HW988_RS08805	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HW988_RS08870	ENOG4107XR4	alpha beta
HW988_RS08940	ENOG4105KPY	Small multidrug resistance protein
HW988_RS08945	ENOG4108YYH	Nadph-dependent fmn reductase
HW988_RS08950	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HW988_RS08955	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HW988_RS08960	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
HW988_RS08965	ENOG4105C08	Histidine kinase
HW988_RS08970	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HW988_RS08990	ENOG4105KME	endoribonuclease L-psp
HW988_RS09005	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HW988_RS09015	ENOG4105D60	lipoprotein releasing system transmembrane protein
HW988_RS09020	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HW988_RS09030	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HW988_RS09035	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HW988_RS09040	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HW988_RS09060	ENOG4105IPI	Membrane
HW988_RS09095	ENOG4105C72	UPF0176 protein
HW988_RS09100	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HW988_RS09105	ENOG4105DA5	(ABC) transporter
HW988_RS09110	ENOG4105E3A	(ABC) transporter
HW988_RS09120	ENOG4105K5M	30s ribosomal protein S16
HW988_RS09130	ENOG41086X0	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HW988_RS09135	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HW988_RS09140	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HW988_RS09145	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HW988_RS09150	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HW988_RS09160	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HW988_RS09195	ENOG4105K70	DNA-binding protein
HW988_RS09225	ENOG4105CSV	Glutaminase
HW988_RS09235	ENOG4105D6N	CoA-transferase, subunit a
HW988_RS09240	ENOG4105CHU	acetyl-coa acetyltransferase
HW988_RS09270	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HW988_RS09280	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HW988_RS09285	ENOG4105E6M	Sulphatase-modifying factor protein
HW988_RS09290	ENOG4108Z0R	Transferase
HW988_RS09295	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HW988_RS09300	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HW988_RS09330	ENOG4105C0B	DNA polymerase III (alpha subunit)
HW988_RS09350	ENOG4105C5S	asparaginyl-tRNA synthetase
HW988_RS09370	ENOG4105CYM	Glutathione S-transferase
HW988_RS09375	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HW988_RS09390	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
HW988_RS09405	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HW988_RS09415	ENOG4105C0H	protease
HW988_RS09435	ENOG4105VB6	UPF0109 protein
HW988_RS09495	ENOG4105C75	arginyL-tRNA synthetase
HW988_RS09505	ENOG4108EU4	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HW988_RS09520	ENOG4105E2Y	ABC, transporter
HW988_RS09525	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
HW988_RS09540	ENOG41086FC	50S ribosomal protein l32
HW988_RS09545	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HW988_RS09550	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HW988_RS09555	ENOG4105CHR	reductase
HW988_RS09560	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HW988_RS09565	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HW988_RS09570	ENOG4108YZG	isomerase
HW988_RS09575	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HW988_RS09580	ENOG4108K5P	(LipO)protein
HW988_RS09600	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HW988_RS09610	ENOG4108YYH	Nadph-dependent fmn reductase
HW988_RS09630	ENOG4105M15	transport protein ExbD
HW988_RS09685	ENOG4105N5T	Radical SAM Protein
HW988_RS09690	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HW988_RS09695	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HW988_RS09720	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HW988_RS09725	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HW988_RS09730	ENOG4108Z4T	Peptidase M50
HW988_RS09735	ENOG4105C1G	acyl-Coa dehydrogenase
HW988_RS09765	ENOG4105CHR	reductase
HW988_RS09775	ENOG4105FE9	pseudouridine synthase
HW988_RS09810	ENOG4105CDY	transcriptional regulatory protein
HW988_RS09855	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HW988_RS09860	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HW988_RS09870	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS09875	ENOG4108WZ2	response regulator
HW988_RS09895	ENOG4105DFU	Cell wall formation (By similarity)
HW988_RS09920	ENOG4108V06	Glutathione peroxidase
HW988_RS09930	ENOG4105C8J	)-transporter
HW988_RS09935	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HW988_RS09945	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HW988_RS09950	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HW988_RS09955	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HW988_RS09960	ENOG4107QI6	Cysteine desulfurase
HW988_RS09980	ENOG4105K8N	protein family UPF0079, ATPase
HW988_RS09985	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HW988_RS09990	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HW988_RS10000	ENOG4105C8B	TIGR00159 family
HW988_RS10005	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HW988_RS10010	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HW988_RS10035	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HW988_RS10055	ENOG4105CBT	Fructose-1,6-bisphosphatase
HW988_RS10060	ENOG41082UD	thioesterase Superfamily protein
HW988_RS10065	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HW988_RS10080	ENOG4107QPK	)-transporter
HW988_RS10115	ENOG4107BJW	polysaccharide deacetylase
HW988_RS10120	ENOG4105CND	Glycosyl transferase, family 2
HW988_RS10225	ENOG4108ZX6	Electron transport protein SCO1 SenC
HW988_RS10235	ENOG4107QWP	ABC-2 type transporter
HW988_RS10240	ENOG4105CJ1	ABC, transporter
HW988_RS10245	ENOG4105CJ1	ABC, transporter
HW988_RS10250	ENOG4105CJ1	ABC, transporter
HW988_RS10255	ENOG4105D0S	secretion protein (HlyD
HW988_RS10265	ENOG4108N3W	hemolysin secretion protein
HW988_RS10270	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HW988_RS10285	ENOG4105CE1	Ferrous iron transport protein b
HW988_RS10305	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HW988_RS10320	ENOG4105DZ0	fad dependent oxidoreductase
HW988_RS10355	ENOG4105D5P	Methylmalonyl-coA mutase
HW988_RS10360	ENOG4105E39	Enoyl-CoA hydratase
HW988_RS10365	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HW988_RS10385	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
HW988_RS10395	ENOG4105BZU	Histidine kinase
HW988_RS10435	ENOG4105DUX	Transporter
HW988_RS10440	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HW988_RS10445	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HW988_RS10450	ENOG4105BZP	glycoside hydrolase 15-related
HW988_RS10470	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HW988_RS10485	ENOG4105C6K	Malic enzyme
HW988_RS10495	ENOG4105E2V	Glycosyltransferase 36
HW988_RS10500	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HW988_RS10520	ENOG4108S4H	thioesterase Superfamily protein
HW988_RS10525	ENOG4105WH1	Two component transcriptional regulator luxr family
HW988_RS10530	ENOG4108VYJ	response regulator receiver protein
HW988_RS10555	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HW988_RS10560	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HW988_RS10575	ENOG4105CMQ	Chloride channel
HW988_RS10580	ENOG41069P5	Protein slyX homolog
HW988_RS10600	ENOG41088SP	formiminoglutamate hydrolase
HW988_RS10605	ENOG4105C5W	Aldolase
HW988_RS10610	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
HW988_RS10615	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HW988_RS10625	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW988_RS10635	ENOG4105CEY	Amp-dependent synthetase and ligase
HW988_RS10650	ENOG4105CNG	UPF0061 protein
HW988_RS10675	ENOG4105EI2	Pseudouridine synthase
HW988_RS10710	ENOG4105KVH	Transcriptional regulator
HW988_RS10715	ENOG4108TKH	Nitroreductase
HW988_RS10720	ENOG4105DEN	Luciferase family
HW988_RS10755	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HW988_RS10770	ENOG4105R8A	Heat shock protein
HW988_RS10790	ENOG4107GFK	fumarate
HW988_RS10815	ENOG4107R4J	Chloride channel
HW988_RS10820	ENOG4107QWG	2-Nitropropane dioxygenase
HW988_RS10850	ENOG4105FCW	Major Facilitator superfamily
HW988_RS10865	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HW988_RS10870	ENOG4105BZU	Histidine kinase
HW988_RS10875	ENOG4105C37	(CBS) domain
HW988_RS10915	ENOG4107QPN	acyl-Coa dehydrogenase
HW988_RS10925	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HW988_RS10950	ENOG4108K3A	Glutathione S-transferase
HW988_RS10985	ENOG4105C5Q	Transcriptional regulator
HW988_RS10990	ENOG4105D3R	alkyl hydroperoxide reductase
HW988_RS10995	ENOG4108JU3	Alkyl hydroperoxide reductase
HW988_RS11015	ENOG4105ERU	peptidase
HW988_RS11020	ENOG4105C3U	ABC transporter
HW988_RS11025	ENOG4108JQ7	(ABC) transporter
HW988_RS11030	ENOG4108J59	Extracellular solute-binding protein, family 5
HW988_RS11040	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HW988_RS11050	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HW988_RS11055	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HW988_RS11060	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HW988_RS11070	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HW988_RS11085	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HW988_RS11090	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HW988_RS11110	ENOG4108R96	Methyltransferase, YaeB family
HW988_RS11115	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HW988_RS11125	ENOG4105EQ0	Major Facilitator superfamily
HW988_RS11140	ENOG4107B2H	carbonic anhydrase
HW988_RS11155	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
HW988_RS11160	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HW988_RS11165	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HW988_RS11200	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HW988_RS11270	ENOG4105C26	Dehydrogenase
HW988_RS11275	ENOG4107S91	Sodium hydrogen exchanger
HW988_RS11285	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HW988_RS11310	ENOG4105BZS	acriflavin resistance protein
HW988_RS11320	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HW988_RS11325	ENOG4108Z66	YbaK ebsC protein
HW988_RS11345	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HW988_RS11360	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HW988_RS11385	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HW988_RS11390	ENOG4105VCH	membrane
HW988_RS11405	ENOG4105BZU	Histidine kinase
HW988_RS11415	ENOG4105D06	uba thif-type nad fad binding protein
HW988_RS11430	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HW988_RS11435	ENOG4107VXZ	Hydrolase
HW988_RS11450	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HW988_RS11505	ENOG4105CJR	Integral membrane protein (MviN
HW988_RS11510	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HW988_RS11515	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HW988_RS11530	ENOG4105C8N	cysteinyl-tRNA synthetase
HW988_RS11535	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HW988_RS11545	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HW988_RS11575	ENOG4105CPI	Metal Dependent Phosphohydrolase
HW988_RS11590	ENOG4105BZU	Histidine kinase
HW988_RS11605	ENOG4105CRK	lysyL-tRNA synthetase
HW988_RS11610	ENOG4105EIE	fructose-bisphosphate aldolase
HW988_RS11615	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
HW988_RS11620	ENOG4107QI1	Mate efflux family protein
HW988_RS11640	ENOG4105BZU	Histidine kinase
HW988_RS11660	ENOG4105QVC	MOSC domain-containing protein
HW988_RS11675	ENOG4105CVE	Lytic murein transglycosylase
HW988_RS11680	ENOG4105CSH	Transporter
HW988_RS11695	ENOG41082K6	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HW988_RS11700	ENOG4105CUZ	uba thif-type nad fad binding protein
HW988_RS11705	ENOG4105F8V	Hydrolase, tatD family
HW988_RS11720	ENOG4108VD1	dedA family
HW988_RS11725	ENOG4105EI2	Pseudouridine synthase
HW988_RS11745	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HW988_RS11765	ENOG4105XA0	heptosyltransferase ii
HW988_RS11770	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HW988_RS11815	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HW988_RS11830	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HW988_RS11850	ENOG4105CBS	Chea signal transduction histidine kinase
HW988_RS11860	ENOG4108VYJ	response regulator receiver protein
HW988_RS11870	ENOG41083ND	50S ribosomal protein L33
HW988_RS11905	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HW988_RS11925	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HW988_RS11940	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HW988_RS11960	ENOG4107W47	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
HW988_RS11965	ENOG4108UHJ	MAF-like protein
HW988_RS11970	ENOG4105KG3	cytidine deaminase
HW988_RS12025	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HW988_RS12035	ENOG4105CJN	penicillin-binding protein
HW988_RS12040	ENOG4105CNI	cell division protein FtsW
HW988_RS12060	ENOG4108Z6Z	Transcriptional regulator
HW988_RS12065	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HW988_RS12080	ENOG4105K63	Thioredoxin
HW988_RS12115	ENOG4108EC8	DNA internalization-related competence protein ComEC
HW988_RS12130	ENOG4105F1Y	L-lysine 6-monooxygenase (NADPH)
HW988_RS12175	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HW988_RS12185	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HW988_RS12190	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HW988_RS12195	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HW988_RS12205	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HW988_RS12255	ENOG4105CR4	methylisocitrate lyase
HW988_RS12300	ENOG4105CX6	glutaminyL-tRNA synthetase
HW988_RS12375	ENOG4107R0U	MotA TolQ exbB proton channel
HW988_RS12380	ENOG4106VK6	Flagellar motor protein
HW988_RS12420	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS12435	ENOG4105EM2	membrane
HW988_RS12445	ENOG4105CD8	aminopeptidase N
HW988_RS12465	ENOG4105EUJ	GTP cyclohydrolase i
HW988_RS12540	ENOG4105BZ1	(ABC) transporter
HW988_RS12545	ENOG4105BZ1	(ABC) transporter
HW988_RS12550	ENOG4105CJW	magnesium transporter
HW988_RS12560	ENOG4105CHR	reductase
HW988_RS12600	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HW988_RS12610	ENOG4105NWN	ApaG protein
HW988_RS12625	ENOG4105KNA	-acetyltransferase
HW988_RS12680	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HW988_RS12685	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HW988_RS12700	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HW988_RS12705	ENOG4105EB3	Histidine kinase
HW988_RS12735	ENOG4105IJJ	transcriptional regulator, crp fnr family
HW988_RS12740	ENOG41090EK	ompa motb domain protein
HW988_RS12750	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HW988_RS12760	ENOG4108RMU	ferritin dps family protein
HW988_RS12775	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HW988_RS12780	ENOG4105BZU	Histidine kinase
HW988_RS12850	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
HW988_RS12860	ENOG4105C26	Dehydrogenase
HW988_RS12880	ENOG4105DBI	uridine monophosphokinase
HW988_RS12885	ENOG4107R7I	amino acid
HW988_RS12900	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HW988_RS12925	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HW988_RS12935	ENOG4106855	Competence protein
HW988_RS12940	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HW988_RS12955	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HW988_RS12990	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HW988_RS13065	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HW988_RS13080	ENOG4105C08	Histidine kinase
HW988_RS13085	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HW988_RS13095	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HW988_RS13100	ENOG4105C26	Dehydrogenase
HW988_RS13105	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HW988_RS13110	ENOG4105VFU	Rna-binding protein
HW988_RS13190	ENOG4105FYV	Amp nucleosidase
HW988_RS13195	ENOG4105EUB	pirin domain protein
HW988_RS13235	ENOG4105CHR	reductase
HW988_RS13255	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HW988_RS13260	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HW988_RS13275	ENOG4107T2S	C-20 methyltransferase BchU
HW988_RS13290	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HW988_RS13315	ENOG4105C84	Histidine ammonia-lyase
HW988_RS13325	ENOG4105HA9	of methanol dehydrogenase type
HW988_RS13330	ENOG4108V0P	LemA family
HW988_RS13335	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HW988_RS13345	ENOG41090FM	Phosphatase
HW988_RS13350	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HW988_RS13355	ENOG4105C1G	acyl-Coa dehydrogenase
HW988_RS13360	ENOG4105CEV	competence damage-inducible protein
HW988_RS13370	ENOG4105FCW	Major Facilitator superfamily
HW988_RS13375	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HW988_RS13380	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HW988_RS13390	ENOG4105C3J	Cysteine desulfurase
HW988_RS13395	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HW988_RS13420	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HW988_RS13425	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HW988_RS13430	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
HW988_RS13435	ENOG410687F	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HW988_RS13465	ENOG4105K4T	epimerase
HW988_RS13470	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HW988_RS13475	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS13505	ENOG4105KPV	Transcriptional regulator
HW988_RS13520	ENOG4105BZ1	(ABC) transporter
HW988_RS13545	ENOG4106P55	Transcriptional regulator
HW988_RS13565	ENOG4105CHR	reductase
HW988_RS13600	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HW988_RS13625	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HW988_RS13645	ENOG4105D1F	ATP-binding protein
HW988_RS13715	ENOG4108RRZ	Transcription elongation factor GreB
HW988_RS13730	ENOG4105F8J	Adenylate Guanylate cyclase
HW988_RS13735	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HW988_RS13740	ENOG4105BZU	Histidine kinase
HW988_RS13750	ENOG4105PWN	phosphate abc transporter
HW988_RS13760	ENOG4108I0Y	(ABC) transporter
HW988_RS13775	ENOG4105CUT	histidyl-tRNA synthetase
HW988_RS13785	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HW988_RS13800	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HW988_RS13825	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HW988_RS13835	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HW988_RS13840	ENOG4105M7K	Involved in the transcription termination process (By similarity)
HW988_RS13855	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HW988_RS13870	ENOG4107RZC	phospholipase d
HW988_RS13880	ENOG4105UT3	Methyl-accepting chemotaxis
HW988_RS13885	ENOG4105DUM	transcriptional regulator, lysR family
HW988_RS13905	ENOG4105X6C	Flagellar basal body-associated protein FliL
HW988_RS13945	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HW988_RS13990	ENOG4105C5Q	Transcriptional regulator
HW988_RS13995	ENOG4105CAT	Cytidine monophosphate kinase
HW988_RS14000	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HW988_RS14015	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HW988_RS14030	ENOG4105C7B	Threonine dehydratase
HW988_RS14045	ENOG4105CP7	Triose-phosphate isomerase
HW988_RS14050	ENOG4105BZA	Phosphoglycerate kinase
HW988_RS14065	ENOG4108UT2	hemolysin iii
HW988_RS14075	ENOG4105F8V	Hydrolase, tatD family
HW988_RS14080	ENOG4107QRG	dna polymerase iii
HW988_RS14085	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HW988_RS14140	ENOG4105D7N	magnesium and cobalt transport protein CorA
HW988_RS14145	ENOG41082K6	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HW988_RS14195	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HW988_RS14205	ENOG4105BZU	Histidine kinase
HW988_RS14210	ENOG4105BZU	Histidine kinase
HW988_RS14215	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HW988_RS14230	ENOG4107R33	ppx gppa phosphatase
HW988_RS14250	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HW988_RS14265	ENOG4108YYC	ycei family
HW988_RS14270	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HW988_RS14280	ENOG4105E2Y	ABC, transporter
HW988_RS14310	ENOG4105C5H	ABC transporter
HW988_RS14315	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HW988_RS14320	ENOG4105DKB	L-sorbosone dehydrogenase
HW988_RS14325	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HW988_RS14330	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HW988_RS14400	ENOG4105VF7	tolerance protein
HW988_RS14405	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HW988_RS14480	ENOG4105CN1	protease
HW988_RS14495	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HW988_RS14510	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HW988_RS14525	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HW988_RS14530	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HW988_RS14550	ENOG4108Z0Z	intracellular protease Pfpi family
HW988_RS14575	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HW988_RS14585	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HW988_RS14595	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS14605	ENOG4105BZU	Histidine kinase
HW988_RS14615	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HW988_RS14620	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HW988_RS14640	ENOG41087EN	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HW988_RS14645	ENOG4105KDC	50s ribosomal protein l28
HW988_RS14650	ENOG41087Z7	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HW988_RS14695	ENOG4105C5Q	Transcriptional regulator
HW988_RS14715	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS14720	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS14730	ENOG4105C7S	Dehydrogenase
HW988_RS14750	ENOG4105CA0	peroxidase
HW988_RS14760	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS14770	ENOG4105BZU	Histidine kinase
HW988_RS14780	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS14795	ENOG4105BZU	Histidine kinase
HW988_RS14820	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HW988_RS14825	ENOG4105HDK	L-asparaginase
HW988_RS14835	ENOG4105D78	K07001 NTE family protein
HW988_RS14870	ENOG4105E8R	UPF0173 metal-dependent hydrolase
HW988_RS14875	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HW988_RS14880	ENOG4105HEI	LysR family (Transcriptional regulator
HW988_RS14920	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HW988_RS14925	ENOG4105BZU	Histidine kinase
HW988_RS14950	ENOG41090A4	Pterin carbinolamine dehydratase
HW988_RS14960	ENOG4105I03	Flagellin
HW988_RS14965	ENOG4108IV0	ABC, transporter
HW988_RS14970	ENOG4105C0Z	ABC transporter
HW988_RS14975	ENOG4105C32	Amino acid ABC transporter (Permease)
HW988_RS14995	ENOG4108ZG0	Ompa motb domain protein
HW988_RS15055	ENOG4105D1H	recombination factor protein RarA
HW988_RS15070	ENOG4105E4G	Type IV pilus
HW988_RS15095	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HW988_RS15105	ENOG4105DA5	(ABC) transporter
HW988_RS15115	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HW988_RS15135	ENOG4105C3F	Signal peptidase i
HW988_RS15145	ENOG4105C3F	Signal peptidase i
HW988_RS15150	ENOG4105C3F	Signal peptidase i
HW988_RS15155	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HW988_RS15160	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HW988_RS15180	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HW988_RS15185	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HW988_RS15190	ENOG4108IUZ	ABC transporter
HW988_RS15250	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HW988_RS15260	ENOG4105C2X	Arabinose 5-phosphate isomerase
HW988_RS15265	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HW988_RS15270	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HW988_RS15275	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HW988_RS15280	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS15295	ENOG4105C2M	dna polymerase I
HW988_RS15310	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HW988_RS15340	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HW988_RS15375	ENOG4106VK6	Flagellar motor protein
HW988_RS15420	ENOG4105J3I	
HW988_RS15490	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HW988_RS15515	ENOG4105CHU	acetyl-coa acetyltransferase
HW988_RS15545	ENOG4108F01	MaoC domain protein
HW988_RS15550	ENOG4108IAB	Phoh family
HW988_RS15565	ENOG4105E0X	reductase
HW988_RS15580	ENOG4105EMN	RNA polymerase sigma factor
HW988_RS15630	ENOG4106PBJ	Serine threonine-protein kinase Pkn6
HW988_RS15635	ENOG4105BZU	Histidine kinase
HW988_RS15650	ENOG4105D56	permease protein
HW988_RS15655	ENOG4105EG2	ABC transporter, permease
HW988_RS15660	ENOG4108IJ9	(ABC) transporter
HW988_RS15665	ENOG4105E54	alpha-amylase
HW988_RS15670	ENOG4105DKQ	ROK family
HW988_RS15680	ENOG4107QP8	phosphohexose isomerase
HW988_RS15695	ENOG4105K56	Transcriptional regulator
HW988_RS15700	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HW988_RS15710	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HW988_RS15755	ENOG4105D82	Glutamate dehydrogenase
HW988_RS15760	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HW988_RS15765	ENOG4105M6F	mutator MutT protein
HW988_RS15780	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HW988_RS15785	ENOG4105CRK	lysyL-tRNA synthetase
HW988_RS15800	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HW988_RS15830	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW988_RS15850	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HW988_RS15950	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HW988_RS15955	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HW988_RS15995	ENOG4105BZU	Histidine kinase
HW988_RS16005	ENOG4105BZU	Histidine kinase
HW988_RS16010	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HW988_RS16055	ENOG4105EHZ	conserved protein UCP016719
HW988_RS16090	ENOG4105DEN	Luciferase family
HW988_RS16120	ENOG4105PNM	synthesis protein
HW988_RS16130	ENOG4108URH	decarboxylase
HW988_RS16140	ENOG4105C1J	atp-dependent rna helicase
HW988_RS16145	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HW988_RS16160	ENOG4108UT2	hemolysin iii
HW988_RS16170	ENOG4105P8F	nudix hydrolase
HW988_RS16185	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HW988_RS16190	ENOG4106A4F	Removes the N-terminal methionine from nascent proteins (By similarity)
HW988_RS16210	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HW988_RS16225	ENOG4105GVJ	transcriptional regulator
HW988_RS16240	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
HW988_RS16280	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HW988_RS16285	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HW988_RS16290	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HW988_RS16305	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HW988_RS16390	ENOG4105C9M	aspartyl-trna synthetase
HW988_RS16400	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HW988_RS16415	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HW988_RS16425	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HW988_RS16430	ENOG4105D7B	Flagellar biosynthesis protein flha
HW988_RS16435	ENOG4105D00	flagellar biosynthetic protein flhB
HW988_RS16440	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HW988_RS16450	ENOG4105CN7	Flagellar biosynthetic protein FliP
HW988_RS16460	ENOG4105DD5	Flagellar motor switch protein
HW988_RS16465	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HW988_RS16485	ENOG4105ECY	inositol monophosphatase
HW988_RS16510	ENOG4105C4R	Atp-dependent dna helicase
HW988_RS16560	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HW988_RS16565	ENOG4105BZ4	penicillin-binding protein
HW988_RS16570	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HW988_RS16580	ENOG4105C08	Histidine kinase
HW988_RS16595	ENOG4107TEJ	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HW988_RS16610	ENOG4108UYB	regulatoR
HW988_RS16625	ENOG4105DSE	periplasmic solute binding protein
HW988_RS16630	ENOG4105FDK	ABC transporter
HW988_RS16645	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HW988_RS16655	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
HW988_RS16660	ENOG4105K70	DNA-binding protein
HW988_RS16665	ENOG4105CTQ	phosphohexokinase
HW988_RS16675	ENOG4105C32	Amino acid ABC transporter (Permease)
HW988_RS16680	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HW988_RS16685	ENOG4105C0Z	ABC transporter
HW988_RS16690	ENOG4108IV0	ABC, transporter
HW988_RS16700	ENOG41062D9	Histidine kinase
HW988_RS16705	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HW988_RS16710	ENOG4105BZE	flagellar hook protein, FlgE
HW988_RS16720	ENOG4105W00	Flagellar hook capping protein
HW988_RS16745	ENOG4105W2B	Flagellar assembly protein
HW988_RS16750	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HW988_RS16755	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HW988_RS16760	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HW988_RS16765	ENOG4108ZC9	flagellar basal-body rod protein flgc
HW988_RS16770	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HW988_RS16775	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS16795	ENOG4105DHJ	ABC, transporter
HW988_RS16820	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HW988_RS16835	ENOG4107T8J	thymidine kinase
HW988_RS16840	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HW988_RS16850	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HW988_RS16855	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HW988_RS16870	ENOG4108MGY	Histidine kinase
HW988_RS16875	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS16880	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HW988_RS16895	ENOG4105CEN	a g-specific adenine glycosylase
HW988_RS16925	ENOG4105D52	delta-aminolevulinic acid dehydratase
HW988_RS16935	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HW988_RS16940	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HW988_RS16950	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HW988_RS16960	ENOG4105D4P	Coproporphyrinogen iii oxidase
HW988_RS16970	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HW988_RS16995	ENOG4108XEP	Alpha Beta Hydrolase Fold protein
HW988_RS17000	ENOG4105DJ0	Poly(A) Polymerase
HW988_RS17005	ENOG4105BZU	Histidine kinase
HW988_RS17010	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HW988_RS17015	ENOG4105BZU	Histidine kinase
HW988_RS17020	ENOG4105CBS	Chea signal transduction histidine kinase
HW988_RS17025	ENOG4108V3W	Chemotaxis protein, CheW
HW988_RS17035	ENOG4107XDR	Lactoylglutathione lyase
HW988_RS17040	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HW988_RS17045	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HW988_RS17070	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HW988_RS17075	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HW988_RS17085	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HW988_RS17090	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HW988_RS17105	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HW988_RS17120	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HW988_RS17125	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HW988_RS17135	ENOG4105D49	3-dehydroquinate synthase
HW988_RS17145	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HW988_RS17175	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HW988_RS17205	ENOG4105CJN	penicillin-binding protein
HW988_RS17220	ENOG4105CGK	Exodeoxyribonuclease III
HW988_RS17245	ENOG4105CN1	protease
HW988_RS17250	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HW988_RS17280	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HW988_RS17285	ENOG4107QUV	Domain protein
HW988_RS17295	ENOG4105KHC	sulfurtransferase
HW988_RS17330	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HW988_RS17335	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HW988_RS17345	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HW988_RS17350	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HW988_RS17370	ENOG4105EWC	Purine nucleoside phosphorylase
HW988_RS17375	ENOG4105C5H	ABC transporter
HW988_RS17390	ENOG4105C5H	ABC transporter
HW988_RS17410	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
HW988_RS17415	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HW988_RS17425	ENOG4105CGU	Enoyl-CoA hydratase
HW988_RS17430	ENOG4107QX3	carboxylase
HW988_RS17460	ENOG4108IUW	ABC transporter
HW988_RS17500	ENOG4105BZU	Histidine kinase
HW988_RS17510	ENOG4105DR4	Methyltransferase
HW988_RS17515	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HW988_RS17520	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HW988_RS17555	ENOG4107VAM	peptidase, m28
HW988_RS17570	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HW988_RS17585	ENOG4105W87	Cbs domain
HW988_RS17595	ENOG4105CGD	Nad-dependent epimerase dehydratase
HW988_RS17600	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HW988_RS17605	ENOG4105CPC	Aldo Keto reductase
HW988_RS17630	ENOG4105C5H	ABC transporter
HW988_RS17670	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
HW988_RS17695	ENOG4105CHJ	isochorismatase hydrolase
HW988_RS17700	ENOG4105CI2	imidazolone-5-propionate hydrolase
HW988_RS17705	ENOG4105C2I	pirin domain protein
HW988_RS17725	ENOG4105C8Q	Methyl-accepting chemotaxis
HW988_RS17730	ENOG4105C5I	Dehydrogenase
HW988_RS17745	ENOG4105CGK	Exodeoxyribonuclease III
HW988_RS17750	ENOG4105ECR	NmrA family
HW988_RS17755	ENOG4105KVH	Transcriptional regulator
HW988_RS17785	ENOG4105VN1	Heat shock protein
HW988_RS17795	ENOG4107S85	alpha-2-macroglobulin domain protein
HW988_RS17800	ENOG4105BZ4	penicillin-binding protein
HW988_RS17810	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HW988_RS17820	ENOG410802X	bacteriophage n4 adsorption protein b
HW988_RS17880	ENOG4105CZ9	Domain of unknown function (DU1801)
HW988_RS17910	ENOG41082BM	Transcriptional regulator, arsr family
HW988_RS17945	ENOG4105D85	methylase
HW988_RS17990	ENOG4105E27	serine threonine protein kinase
HW988_RS18015	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HW988_RS18020	ENOG4108IUS	Transketolase
HW988_RS18025	ENOG4108HHA	Transketolase
HW988_RS18120	ENOG4105C6E	dna polymerase iii
HW988_RS18130	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HW988_RS18135	ENOG4105CXV	gliding motility protein
HW988_RS18140	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HW988_RS18190	ENOG4105JQN	Transcriptional regulator
HW988_RS18200	ENOG4105C4W	S-formylglutathione hydrolase
HW988_RS18215	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HW988_RS18220	ENOG4105BZU	Histidine kinase
HW988_RS18225	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HW988_RS18235	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HW988_RS18240	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HW988_RS18245	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HW988_RS18250	ENOG4107RZC	phospholipase d
HW988_RS18285	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HW988_RS18295	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HW988_RS18305	ENOG4105CN1	protease
HW988_RS18320	ENOG4105CAK	Cell division ATP-binding protein ftsE
HW988_RS18335	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HW988_RS18345	ENOG4108JQC	penicillin-binding protein 1A
HW988_RS18350	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HW988_RS18355	ENOG4105BZ1	(ABC) transporter
HW988_RS18365	ENOG4108JUA	Transcriptional regulator
HW988_RS18375	ENOG4105EHM	Aminoglycoside phosphotransferase
HW988_RS18380	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HW988_RS18405	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HW988_RS18430	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HW988_RS18440	ENOG4105C25	Primosomal protein n'
HW988_RS18455	ENOG4105CE9	30S ribosomal protein S2
HW988_RS18460	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HW988_RS18465	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HW988_RS18470	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HW988_RS18475	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HW988_RS18480	ENOG4105KNE	Phosphatidate cytidylyltransferase
HW988_RS18485	ENOG4105DZP	Membrane-associated zinc metalloprotease
HW988_RS18490	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HW988_RS18510	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HW988_RS18515	ENOG4108VX5	3-methyladenine DNA glycosylase
HW988_RS18530	ENOG4105C28	cystathionine
HW988_RS18575	ENOG4105DHJ	ABC, transporter
HW988_RS18580	ENOG4105DHJ	ABC, transporter
HW988_RS18585	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HW988_RS18590	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HW988_RS18620	ENOG4105C0H	protease
HW988_RS18625	ENOG4107SZR	mannose-6-phosphate isomerase
HW988_RS18635	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HW988_RS18640	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HW988_RS18650	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
HW988_RS18665	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HW988_RS18670	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HW988_RS18695	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HW988_RS18715	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HW988_RS18720	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HW988_RS18725	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW988_RS18730	ENOG4105K46	50S ribosomal protein l27
HW988_RS18735	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HW988_RS18745	ENOG4105C03	ribonuclease
HW988_RS18750	ENOG4105CZX	twitching motility protein
HW988_RS18755	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HW988_RS18785	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HW988_RS18795	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HW988_RS18800	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HW988_RS18810	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HW988_RS18825	ENOG4105CSA	Coproporphyrinogen iii oxidase
HW988_RS18830	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW988_RS18835	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HW988_RS18855	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HW988_RS18900	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HW988_RS18905	ENOG4105C8S	subunit m
HW988_RS18915	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HW988_RS18920	ENOG4105DF2	NADH dehydrogenase subunit j
HW988_RS18925	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HW988_RS18930	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HW988_RS18935	ENOG4108JA2	transcriptioN-repair coupling factor
HW988_RS18945	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HW988_RS18955	ENOG4105DVT	helicase
HW988_RS18965	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HW988_RS18970	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HW988_RS18975	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HW988_RS18980	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HW988_RS18985	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HW988_RS18990	ENOG4105TYC	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HW988_RS19010	ENOG4107QJE	Chromosome Partitioning Protein
HW988_RS19020	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HW988_RS19025	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HW988_RS19030	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HW988_RS19040	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HW988_RS19045	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)