locus-tag	class	description
HW988_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW988_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW988_RS00020	COG0187	DNA topoisomerase II activity
HW988_RS00045	COG0356	it plays a direct role in the translocation of protons across the membrane
HW988_RS00050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW988_RS00055	COG0789	Transcriptional regulator
HW988_RS00065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HW988_RS00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW988_RS00080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW988_RS00090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW988_RS00095	COG2086	electron transfer activity
HW988_RS00105	COG1053	succinate dehydrogenase
HW988_RS00130	COG2267	carboxylic ester hydrolase activity
HW988_RS00140	COG0360	Binds together with S18 to 16S ribosomal RNA
HW988_RS00150	COG0359	binds to the 23S rRNA
HW988_RS00165	COG0300	oxidoreductase activity
HW988_RS00170	COG0305	Participates in initiation and elongation during chromosome replication
HW988_RS00180	COG0602	queuosine metabolic process
HW988_RS00185	COG1674	ftsk spoiiie
HW988_RS00205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HW988_RS00210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW988_RS00215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HW988_RS00225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW988_RS00255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HW988_RS00265	COG0154	amidase activity
HW988_RS00270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW988_RS00275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW988_RS00275	COG0248	Ppx GppA phosphatase
HW988_RS00295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HW988_RS00310	COG0254	rRNA binding
HW988_RS00315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW988_RS00320	COG2890	protein-(glutamine-N5) methyltransferase activity
HW988_RS00325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HW988_RS00350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HW988_RS00370	COG0586	Pfam SNARE associated Golgi protein
HW988_RS00395	COG0590	tRNA wobble adenosine to inosine editing
HW988_RS00405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HW988_RS00410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HW988_RS00425	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW988_RS00490	COG0318	PFAM AMP-dependent synthetase and ligase
HW988_RS00500	COG3848	Pyruvate phosphate dikinase
HW988_RS00500	COG0574	Belongs to the PEP-utilizing enzyme family
HW988_RS00520	COG1136	(ABC) transporter
HW988_RS00575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW988_RS00580	COG0459	protein refolding
HW988_RS00595	COG2201	protein-glutamate methylesterase activity
HW988_RS00670	COG0840	transmembrane signaling receptor activity
HW988_RS00695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW988_RS00700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW988_RS00710	COG1012	belongs to the aldehyde dehydrogenase family
HW988_RS00715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW988_RS00725	COG0527	aspartate kinase activity
HW988_RS00735	COG0840	transmembrane signaling receptor activity
HW988_RS00740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW988_RS00750	COG1131	(ABC) transporter
HW988_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW988_RS00765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW988_RS00770	COG0671	phosphoesterase, PA-phosphatase related
HW988_RS00775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW988_RS00780	COG1360	Flagellar Motor Protein
HW988_RS00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW988_RS00820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HW988_RS00825	COG0823	Involved in the tonB-independent uptake of proteins
HW988_RS00855	COG0719	Fe-S assembly protein
HW988_RS00860	COG0396	ATPase activity
HW988_RS00865	COG0719	Fe-S assembly protein
HW988_RS00870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW988_RS00905	COG1722	exodeoxyribonuclease VII activity
HW988_RS00910	COG0142	geranyltranstransferase activity
HW988_RS00925	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HW988_RS00935	COG0006	proline dipeptidase activity
HW988_RS00960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW988_RS00965	COG1077	Cell shape determining protein MreB Mrl
HW988_RS00990	COG2003	Belongs to the UPF0758 family
HW988_RS01005	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HW988_RS01030	COG2766	serine protein kinase
HW988_RS01035	COG2718	Belongs to the UPF0229 family
HW988_RS01040	COG2719	SpoVR family
HW988_RS01050	COG0745	RESPONSE REGULATOR receiver
HW988_RS01080	COG0590	tRNA wobble adenosine to inosine editing
HW988_RS01090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HW988_RS01095	COG1610	YqeY-like protein
HW988_RS01100	COG0358	DNA primase activity
HW988_RS01120	COG1607	acyl-coa hydrolase
HW988_RS01175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW988_RS01225	COG0653	protein targeting
HW988_RS01265	COG1064	alcohol dehydrogenase
HW988_RS01270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW988_RS01290	COG0509	glycine decarboxylation via glycine cleavage system
HW988_RS01300	COG0347	Belongs to the P(II) protein family
HW988_RS01310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW988_RS01315	COG0653	protein targeting
HW988_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS01365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW988_RS01365	COG1845	cytochrome c oxidase, subunit III
HW988_RS01370	COG1845	cytochrome c oxidase, subunit III
HW988_RS01380	COG0109	protoheme IX farnesyltransferase activity
HW988_RS01405	COG2032	superoxide dismutase activity
HW988_RS01430	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW988_RS01440	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HW988_RS01465	COG0357	Ribosomal RNA small subunit methyltransferase G
HW988_RS01485	COG1061	Type III restriction enzyme res subunit
HW988_RS01515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HW988_RS01530	COG2070	2-Nitropropane dioxygenase
HW988_RS01555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HW988_RS01565	COG1393	Belongs to the ArsC family
HW988_RS01675	COG0513	Belongs to the DEAD box helicase family
HW988_RS01685	COG2855	membrane
HW988_RS01690	COG0656	L-ascorbic acid biosynthetic process
HW988_RS01705	COG2223	nitrite transmembrane transporter activity
HW988_RS01720	COG1047	Peptidyl-prolyl cis-trans
HW988_RS01725	COG1666	GTP binding
HW988_RS01730	COG0724	RNA recognition motif
HW988_RS01740	COG4181	ATPase activity
HW988_RS01750	COG0009	L-threonylcarbamoyladenylate synthase
HW988_RS01765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW988_RS01775	COG1393	Belongs to the ArsC family
HW988_RS01780	COG0010	Belongs to the arginase family
HW988_RS01785	COG4166	transmembrane transport
HW988_RS01790	COG4174	ABC transporter (Permease)
HW988_RS01795	COG4239	(ABC) transporter, permease
HW988_RS01810	COG1166	arginine decarboxylase activity
HW988_RS01815	COG0495	leucyl-tRNA aminoacylation
HW988_RS01825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW988_RS01830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW988_RS01840	COG0492	ferredoxin-NADP+ reductase activity
HW988_RS01900	COG0587	DNA-directed DNA polymerase activity
HW988_RS01945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HW988_RS01990	COG0739	heme binding
HW988_RS02010	COG0183	Belongs to the thiolase family
HW988_RS02040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW988_RS02045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW988_RS02060	COG0583	DNA-binding transcription factor activity
HW988_RS02065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HW988_RS02070	COG0557	exoribonuclease II activity
HW988_RS02090	COG0840	transmembrane signaling receptor activity
HW988_RS02120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW988_RS02140	COG0525	valine-tRNA ligase activity
HW988_RS02165	COG1872	DUF167
HW988_RS02175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW988_RS02180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW988_RS02195	COG0424	maF-like protein
HW988_RS02220	COG1716	ATPase activity
HW988_RS02265	COG1183	phosphatidylcholine synthase activity
HW988_RS02270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW988_RS02295	COG0101	tRNA pseudouridine synthase activity
HW988_RS02300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW988_RS02305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HW988_RS02315	COG1505	serine-type exopeptidase activity
HW988_RS02320	COG0840	transmembrane signaling receptor activity
HW988_RS02345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW988_RS02355	COG1408	metallophosphoesterase
HW988_RS02360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW988_RS02370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW988_RS02375	COG1058	Belongs to the CinA family
HW988_RS02375	COG1546	Belongs to the CinA family
HW988_RS02380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HW988_RS02420	COG0386	Belongs to the glutathione peroxidase family
HW988_RS02445	COG4786	Flagellar basal body rod
HW988_RS02450	COG4786	Flagellar basal body rod
HW988_RS02465	COG1706	bacterial-type flagellum-dependent cell motility
HW988_RS02485	COG1256	bacterial-type flagellum assembly
HW988_RS02500	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HW988_RS02520	COG1575	Belongs to the MenA family. Type 1 subfamily
HW988_RS02530	COG0318	PFAM AMP-dependent synthetase and ligase
HW988_RS02550	COG0824	Thioesterase
HW988_RS02555	COG0142	geranyltranstransferase activity
HW988_RS02565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW988_RS02600	COG0372	Belongs to the citrate synthase family
HW988_RS02615	COG0537	adenosine 5'-monophosphoramidase activity
HW988_RS02645	COG0643	Histidine kinase
HW988_RS02645	COG2198	Histidine kinase
HW988_RS02655	COG2201	protein-glutamate methylesterase activity
HW988_RS02665	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW988_RS02670	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HW988_RS02690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW988_RS02710	COG3842	ATPase activity
HW988_RS02715	COG0784	Response regulator, receiver
HW988_RS02715	COG2205	protein histidine kinase activity
HW988_RS02725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW988_RS02735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW988_RS02745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HW988_RS02750	COG1516	flagellar protein fliS
HW988_RS02785	COG3852	Histidine kinase
HW988_RS02795	COG0742	ribosomal rna small subunit methyltransferase
HW988_RS02800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HW988_RS02805	COG0436	Aminotransferase
HW988_RS02845	COG5640	endopeptidase activity
HW988_RS02865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW988_RS02880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW988_RS02920	COG4221	oxidoreductase activity
HW988_RS02940	COG0726	polysaccharide deacetylase
HW988_RS02950	COG0726	polysaccharide deacetylase
HW988_RS02970	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HW988_RS02970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HW988_RS02980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW988_RS02985	COG2264	protein methyltransferase activity
HW988_RS03015	COG1187	pseudouridine synthase activity
HW988_RS03055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW988_RS03060	COG1360	Flagellar Motor Protein
HW988_RS03070	COG2176	DNA-directed DNA polymerase activity
HW988_RS03075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW988_RS03080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW988_RS03090	COG0741	lytic transglycosylase activity
HW988_RS03090	COG0739	heme binding
HW988_RS03090	COG1196	nuclear chromosome segregation
HW988_RS03110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW988_RS03125	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HW988_RS03135	COG2119	membrane
HW988_RS03140	COG0724	RNA recognition motif
HW988_RS03145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW988_RS03160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HW988_RS03170	COG0275	rRNA processing
HW988_RS03180	COG0768	penicillin binding
HW988_RS03200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW988_RS03205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW988_RS03225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW988_RS03230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW988_RS03245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW988_RS03250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW988_RS03275	COG0840	transmembrane signaling receptor activity
HW988_RS03280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HW988_RS03290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW988_RS03295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HW988_RS03370	COG0497	DNA recombination
HW988_RS03375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW988_RS03380	COG0339	signal peptide processing
HW988_RS03405	COG1960	acyl-CoA dehydrogenase activity
HW988_RS03410	COG1022	Amp-dependent synthetase and ligase
HW988_RS03420	COG0237	dephospho-CoA kinase activity
HW988_RS03465	COG1074	ATP-dependent DNA helicase activity
HW988_RS03470	COG0328	RNA-DNA hybrid ribonuclease activity
HW988_RS03475	COG0300	oxidoreductase activity
HW988_RS03495	COG2205	protein histidine kinase activity
HW988_RS03505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HW988_RS03510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW988_RS03515	COG1127	ABC transporter
HW988_RS03520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HW988_RS03535	COG3481	metal-dependent phosphohydrolase, HD sub domain
HW988_RS03540	COG1045	serine acetyltransferase
HW988_RS03555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HW988_RS03570	COG1643	Atp-dependent helicase
HW988_RS03590	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HW988_RS03595	COG3639	organic phosphonate transmembrane transporter activity
HW988_RS03615	COG1132	(ABC) transporter
HW988_RS03620	COG1132	(ABC) transporter
HW988_RS03670	COG3220	belongs to the UPF0276 family
HW988_RS03675	COG2353	YceI-like domain
HW988_RS03685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW988_RS03690	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW988_RS03690	COG0649	NAD binding
HW988_RS03695	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HW988_RS03705	COG1034	ATP synthesis coupled electron transport
HW988_RS03710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW988_RS03735	COG0583	DNA-binding transcription factor activity
HW988_RS03765	COG1381	Involved in DNA repair and RecF pathway recombination
HW988_RS03770	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HW988_RS03775	COG2204	response regulator
HW988_RS03795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW988_RS03800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HW988_RS03810	COG0542	response to heat
HW988_RS03835	COG0307	riboflavin synthase, alpha
HW988_RS03840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW988_RS03840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW988_RS03845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HW988_RS03850	COG5000	phosphorelay sensor kinase activity
HW988_RS03855	COG2204	response regulator
HW988_RS03860	COG0442	prolyl-tRNA aminoacylation
HW988_RS03870	COG0284	orotidine-5'-phosphate decarboxylase activity
HW988_RS03875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW988_RS03900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW988_RS03915	COG0250	Participates in transcription elongation, termination and antitermination
HW988_RS03920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW988_RS03925	COG0081	regulation of translation
HW988_RS03930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW988_RS03935	COG0222	ribosome binding
HW988_RS03940	COG0085	RNA polymerase activity
HW988_RS03945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HW988_RS03950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW988_RS03955	COG0049	tRNA binding
HW988_RS03960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW988_RS03965	COG0051	transcription antitermination factor activity, RNA binding
HW988_RS03970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HW988_RS03975	COG0088	Forms part of the polypeptide exit tunnel
HW988_RS03980	COG0089	rRNA binding
HW988_RS03985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW988_RS03990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW988_RS03995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW988_RS04000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HW988_RS04005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW988_RS04010	COG0255	Belongs to the universal ribosomal protein uL29 family
HW988_RS04015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HW988_RS04020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW988_RS04025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HW988_RS04030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW988_RS04035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HW988_RS04040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HW988_RS04045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HW988_RS04050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW988_RS04055	COG1841	ribosomal large subunit assembly
HW988_RS04060	COG0200	Binds to the 23S rRNA
HW988_RS04065	COG0201	protein transport
HW988_RS04070	COG0563	adenylate kinase activity
HW988_RS04075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW988_RS04080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW988_RS04085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HW988_RS04090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HW988_RS04095	COG0202	RNA polymerase activity
HW988_RS04100	COG0203	ribosomal protein L17
HW988_RS04105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW988_RS04115	COG0784	Response regulator, receiver
HW988_RS04115	COG2198	Histidine kinase
HW988_RS04115	COG2205	protein histidine kinase activity
HW988_RS04115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW988_RS04130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HW988_RS04165	COG1960	acyl-CoA dehydrogenase activity
HW988_RS04185	COG0840	transmembrane signaling receptor activity
HW988_RS04205	COG0366	Alpha amylase catalytic
HW988_RS04210	COG2267	carboxylic ester hydrolase activity
HW988_RS04220	COG0714	Associated with various cellular activities
HW988_RS04225	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HW988_RS04245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW988_RS04260	COG0427	acetyl-CoA hydrolase
HW988_RS04265	COG3237	CsbD-like
HW988_RS04280	COG2995	paraquat-inducible protein a
HW988_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS04355	COG0438	transferase activity, transferring glycosyl groups
HW988_RS04375	COG1902	pentaerythritol trinitrate reductase activity
HW988_RS04395	COG1295	ribonuclease BN
HW988_RS04405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW988_RS04415	COG4589	Belongs to the CDS family
HW988_RS04425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW988_RS04445	COG1879	ABC-type sugar transport system periplasmic component
HW988_RS04450	COG0277	FAD linked oxidase domain protein
HW988_RS04460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HW988_RS04470	COG1368	sulfuric ester hydrolase activity
HW988_RS04540	COG1027	Aspartate ammonia-lyase
HW988_RS04565	COG1902	pentaerythritol trinitrate reductase activity
HW988_RS04575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW988_RS04640	COG0784	Response regulator, receiver
HW988_RS04640	COG5002	protein histidine kinase activity
HW988_RS04640	COG2198	Histidine kinase
HW988_RS04645	COG0784	Response regulator, receiver
HW988_RS04645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW988_RS04645	COG2198	Histidine kinase
HW988_RS04645	COG2205	protein histidine kinase activity
HW988_RS04665	COG0724	RNA recognition motif
HW988_RS04680	COG1271	oxidase subunit
HW988_RS04700	COG0741	lytic transglycosylase activity
HW988_RS04710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW988_RS04715	COG0835	chemotaxis
HW988_RS04750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW988_RS04775	COG0402	S-adenosylhomocysteine deaminase activity
HW988_RS04780	COG0786	glutamate:sodium symporter activity
HW988_RS04825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW988_RS04825	COG0784	Response regulator, receiver
HW988_RS04825	COG2205	protein histidine kinase activity
HW988_RS04825	COG2198	Histidine kinase
HW988_RS04830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW988_RS04835	COG0784	Response regulator, receiver
HW988_RS04835	COG2205	protein histidine kinase activity
HW988_RS04855	COG1335	isochorismatase
HW988_RS04885	COG2375	cellular response to nickel ion
HW988_RS04925	COG1408	metallophosphoesterase
HW988_RS04960	COG0583	DNA-binding transcription factor activity
HW988_RS04965	COG1064	alcohol dehydrogenase
HW988_RS04970	COG0667	Aldo Keto reductase
HW988_RS04980	COG1671	Belongs to the UPF0178 family
HW988_RS04985	COG0475	glutathione-regulated potassium exporter activity
HW988_RS05025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW988_RS05035	COG1192	Involved in chromosome partitioning
HW988_RS05075	COG5002	protein histidine kinase activity
HW988_RS05085	COG3604	Transcriptional regulator
HW988_RS05090	COG0071	Belongs to the small heat shock protein (HSP20) family
HW988_RS05105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HW988_RS05135	COG3040	lipid binding
HW988_RS05140	COG3040	lipid binding
HW988_RS05160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW988_RS05165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW988_RS05205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HW988_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS05220	COG0583	DNA-binding transcription factor activity
HW988_RS05240	COG2234	aminopeptidase activity
HW988_RS05255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW988_RS05275	COG2088	sporulation resulting in formation of a cellular spore
HW988_RS05285	COG0840	transmembrane signaling receptor activity
HW988_RS05300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW988_RS05310	COG0501	Belongs to the peptidase M48B family
HW988_RS05315	COG0714	Associated with various cellular activities
HW988_RS05335	COG2304	oxidoreductase activity
HW988_RS05380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HW988_RS05385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW988_RS05405	COG2832	Protein of unknown function (DUF454)
HW988_RS05420	COG2843	Capsule synthesis protein
HW988_RS05480	COG0861	Integral membrane protein TerC family
HW988_RS05525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HW988_RS05525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HW988_RS05535	COG0835	chemotaxis
HW988_RS05535	COG0784	Response regulator, receiver
HW988_RS05545	COG0242	peptide deformylase activity
HW988_RS05550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW988_RS05565	COG0494	nUDIX hydrolase
HW988_RS05600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HW988_RS05610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW988_RS05705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW988_RS05710	COG1695	Transcriptional regulator
HW988_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS05740	COG0583	DNA-binding transcription factor activity
HW988_RS05750	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW988_RS05755	COG0567	Dehydrogenase, E1 component
HW988_RS05760	COG0588	phosphoglycerate mutase activity
HW988_RS05765	COG0071	Belongs to the small heat shock protein (HSP20) family
HW988_RS05780	COG0110	maltose O-acetyltransferase activity
HW988_RS05785	COG1228	amidohydrolase
HW988_RS05805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HW988_RS05825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HW988_RS05835	COG0601	transmembrane transport
HW988_RS05840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW988_RS05855	COG0012	GTP binding
HW988_RS05860	COG0193	aminoacyl-tRNA hydrolase activity
HW988_RS05865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HW988_RS05870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HW988_RS05880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW988_RS05885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HW988_RS05890	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW988_RS05905	COG0740	serine-type endopeptidase activity
HW988_RS05910	COG0668	transmembrane transport
HW988_RS05915	COG1968	undecaprenyl-diphosphatase activity
HW988_RS05930	COG1024	Enoyl-CoA hydratase
HW988_RS05945	COG2917	probably involved in intracellular septation
HW988_RS05950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW988_RS05970	COG2259	Doxx family
HW988_RS06060	COG2814	Major facilitator Superfamily
HW988_RS06065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW988_RS06090	COG4269	membrane
HW988_RS06100	COG3214	Protein conserved in bacteria
HW988_RS06185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW988_RS06190	COG0519	Catalyzes the synthesis of GMP from XMP
HW988_RS06240	COG0443	Heat shock 70 kDa protein
HW988_RS06245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW988_RS06255	COG2897	thiosulfate sulfurtransferase activity
HW988_RS06270	COG0730	response to heat
HW988_RS06275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW988_RS06285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW988_RS06335	COG1136	(ABC) transporter
HW988_RS06335	COG0577	efflux transmembrane transporter activity
HW988_RS06350	COG3012	SEC-C Motif Domain Protein
HW988_RS06355	COG4221	oxidoreductase activity
HW988_RS06380	COG0564	pseudouridine synthase activity
HW988_RS06410	COG4106	trans-aconitate 2-methyltransferase activity
HW988_RS06420	COG0488	(ABC) transporter
HW988_RS06425	COG0784	Response regulator, receiver
HW988_RS06425	COG2205	protein histidine kinase activity
HW988_RS06440	COG0024	Methionine aminopeptidase
HW988_RS06445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HW988_RS06475	COG3237	CsbD-like
HW988_RS06495	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HW988_RS06500	COG0745	RESPONSE REGULATOR receiver
HW988_RS06525	COG2850	peptidyl-arginine hydroxylation
HW988_RS06535	COG0386	Belongs to the glutathione peroxidase family
HW988_RS06560	COG5002	protein histidine kinase activity
HW988_RS06560	COG2198	Histidine kinase
HW988_RS06560	COG0784	Response regulator, receiver
HW988_RS06575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW988_RS06595	COG0039	L-malate dehydrogenase activity
HW988_RS06615	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW988_RS06630	COG1404	Belongs to the peptidase S8 family
HW988_RS06665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW988_RS06685	COG0840	transmembrane signaling receptor activity
HW988_RS06720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW988_RS06730	COG0840	transmembrane signaling receptor activity
HW988_RS06735	COG0826	peptidase U32
HW988_RS06745	COG0840	transmembrane signaling receptor activity
HW988_RS06750	COG0513	Belongs to the DEAD box helicase family
HW988_RS06770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW988_RS06785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW988_RS06810	COG3034	peptidoglycan biosynthetic process
HW988_RS06860	COG0281	malic enzyme
HW988_RS06880	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HW988_RS06890	COG0513	Belongs to the DEAD box helicase family
HW988_RS06905	COG0095	Lipoate-protein ligase
HW988_RS06965	COG0513	Belongs to the DEAD box helicase family
HW988_RS06970	COG0488	(ABC) transporter
HW988_RS06985	COG2270	Major facilitator Superfamily
HW988_RS06995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HW988_RS07025	COG1418	mRNA catabolic process
HW988_RS07045	COG1404	Belongs to the peptidase S8 family
HW988_RS07050	COG1956	GAF domain-containing protein
HW988_RS07065	COG2326	polyphosphate kinase activity
HW988_RS07070	COG1764	response to oxidative stress
HW988_RS07080	COG2202	Pas domain
HW988_RS07080	COG2205	protein histidine kinase activity
HW988_RS07095	COG4251	negative regulation of phosphorylation
HW988_RS07100	COG0784	Response regulator, receiver
HW988_RS07105	COG5002	protein histidine kinase activity
HW988_RS07110	COG5002	protein histidine kinase activity
HW988_RS07110	COG2198	Histidine kinase
HW988_RS07110	COG0784	Response regulator, receiver
HW988_RS07120	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HW988_RS07135	COG2267	carboxylic ester hydrolase activity
HW988_RS07165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HW988_RS07170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW988_RS07175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HW988_RS07185	COG1466	dna polymerase III delta subunit
HW988_RS07205	COG0268	Binds directly to 16S ribosomal RNA
HW988_RS07210	COG0728	peptidoglycan biosynthetic process
HW988_RS07215	COG0840	transmembrane signaling receptor activity
HW988_RS07220	COG0840	transmembrane signaling receptor activity
HW988_RS07225	COG0840	transmembrane signaling receptor activity
HW988_RS07270	COG0811	peptide transport
HW988_RS07290	COG3956	TIGRFAM MazG family protein
HW988_RS07300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HW988_RS07315	COG1136	(ABC) transporter
HW988_RS07335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HW988_RS07350	COG1663	tetraacyldisaccharide 4'-kinase activity
HW988_RS07355	COG1560	Kdo2-lipid A biosynthetic process
HW988_RS07380	COG0859	PFAM glycosyl transferase family 9
HW988_RS07385	COG2204	response regulator
HW988_RS07390	COG2205	protein histidine kinase activity
HW988_RS07395	COG0196	riboflavin kinase activity
HW988_RS07420	COG3852	Histidine kinase
HW988_RS07425	COG2204	response regulator
HW988_RS07440	COG0412	Dienelactone hydrolase
HW988_RS07480	COG1404	Belongs to the peptidase S8 family
HW988_RS07495	COG0564	pseudouridine synthase activity
HW988_RS07580	COG0779	Required for maturation of 30S ribosomal subunits
HW988_RS07585	COG0195	Participates in both transcription termination and antitermination
HW988_RS07590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW988_RS07595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HW988_RS07600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HW988_RS07605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HW988_RS07610	COG1185	polyribonucleotide nucleotidyltransferase activity
HW988_RS07615	COG0612	Peptidase, M16
HW988_RS07620	COG0756	dUTP diphosphatase activity
HW988_RS07650	COG1216	Glycosyl transferase, family 2
HW988_RS07665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HW988_RS07670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HW988_RS07675	COG1561	YicC-like family, N-terminal region
HW988_RS07680	COG0194	GDP metabolic process
HW988_RS07685	COG1758	RNA polymerase activity
HW988_RS07695	COG3852	Histidine kinase
HW988_RS07755	COG2165	general secretion pathway protein
HW988_RS07770	COG1450	Type ii and iii secretion system protein
HW988_RS07810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HW988_RS07820	COG0151	Belongs to the GarS family
HW988_RS07825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW988_RS07830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW988_RS07835	COG0047	phosphoribosylformylglycinamidine synthase activity
HW988_RS07840	COG0138	bifunctional purine biosynthesis protein purh
HW988_RS07880	COG2096	Adenosyltransferase
HW988_RS07890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW988_RS07890	COG1333	cytochrome c biogenesis protein
HW988_RS07895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW988_RS07895	COG1333	cytochrome c biogenesis protein
HW988_RS07905	COG0437	4 iron, 4 sulfur cluster binding
HW988_RS07945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW988_RS07950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HW988_RS07975	COG0584	glycerophosphoryl diester phosphodiesterase
HW988_RS07995	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW988_RS08000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW988_RS08005	COG1304	FMN binding
HW988_RS08040	COG1136	(ABC) transporter
HW988_RS08075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW988_RS08075	COG0357	Ribosomal RNA small subunit methyltransferase G
HW988_RS08080	COG0357	Ribosomal RNA small subunit methyltransferase G
HW988_RS08085	COG2031	fatty acid transporter
HW988_RS08095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HW988_RS08100	COG0072	phenylalanine-tRNA ligase activity
HW988_RS08100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW988_RS08105	COG0776	regulation of translation
HW988_RS08170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HW988_RS08190	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW988_RS08195	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW988_RS08245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HW988_RS08250	COG0343	queuine tRNA-ribosyltransferase activity
HW988_RS08255	COG1862	Preprotein translocase
HW988_RS08260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW988_RS08265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW988_RS08270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW988_RS08275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HW988_RS08295	COG2217	Heavy metal translocating P-type atpase
HW988_RS08325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW988_RS08330	COG1612	heme a metabolic process
HW988_RS08330	COG0109	protoheme IX farnesyltransferase activity
HW988_RS08380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW988_RS08390	COG0415	Belongs to the DNA photolyase family
HW988_RS08405	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HW988_RS08415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW988_RS08435	COG0735	belongs to the Fur family
HW988_RS08455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW988_RS08460	COG0573	inorganic phosphate transmembrane transporter activity
HW988_RS08465	COG0581	inorganic phosphate transmembrane transporter activity
HW988_RS08470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW988_RS08490	COG1215	transferase activity, transferring glycosyl groups
HW988_RS08515	COG0463	Glycosyl transferase, family 2
HW988_RS08520	COG2755	lipolytic protein G-D-S-L family
HW988_RS08520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW988_RS08580	COG0277	FAD linked oxidase domain protein
HW988_RS08585	COG0546	phosphoglycolate phosphatase activity
HW988_RS08585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HW988_RS08600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW988_RS08640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW988_RS08665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW988_RS08665	COG2755	lipolytic protein G-D-S-L family
HW988_RS08700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW988_RS08730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW988_RS08735	COG3021	interspecies interaction between organisms
HW988_RS08775	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HW988_RS08785	COG3932	Exopolysaccharide synthesis, ExoD
HW988_RS08795	COG1720	tRNA m6t6A37 methyltransferase activity
HW988_RS08805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW988_RS08805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW988_RS08820	COG1077	Cell shape determining protein MreB Mrl
HW988_RS08870	COG1073	alpha beta
HW988_RS08940	COG2076	Multidrug Resistance protein
HW988_RS08945	COG0431	NADPH-dependent FMN reductase
HW988_RS08950	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HW988_RS08955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HW988_RS08960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HW988_RS08965	COG2205	protein histidine kinase activity
HW988_RS08970	COG0745	RESPONSE REGULATOR receiver
HW988_RS09000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW988_RS09005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW988_RS09015	COG4591	ABC-type transport system involved in lipoprotein release permease component
HW988_RS09020	COG2171	N-acyltransferase activity
HW988_RS09030	COG0019	diaminopimelate decarboxylase activity
HW988_RS09035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HW988_RS09040	COG0517	IMP dehydrogenase activity
HW988_RS09040	COG0516	GMP reductase activity
HW988_RS09060	COG0628	permease
HW988_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS09100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HW988_RS09105	COG1131	(ABC) transporter
HW988_RS09110	COG0842	Transport permease protein
HW988_RS09115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW988_RS09120	COG0228	four-way junction DNA binding
HW988_RS09130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HW988_RS09135	COG0336	Belongs to the RNA methyltransferase TrmD family
HW988_RS09140	COG4752	Belongs to the RNA methyltransferase TrmD family
HW988_RS09140	COG0336	Belongs to the RNA methyltransferase TrmD family
HW988_RS09145	COG0335	large ribosomal subunit rRNA binding
HW988_RS09150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW988_RS09160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HW988_RS09195	COG0776	regulation of translation
HW988_RS09225	COG2066	Belongs to the glutaminase family
HW988_RS09225	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HW988_RS09235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW988_RS09240	COG0183	Belongs to the thiolase family
HW988_RS09270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW988_RS09280	COG4651	solute:proton antiporter activity
HW988_RS09280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW988_RS09285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HW988_RS09290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW988_RS09295	COG0517	IMP dehydrogenase activity
HW988_RS09295	COG0516	GMP reductase activity
HW988_RS09300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HW988_RS09300	COG0519	Catalyzes the synthesis of GMP from XMP
HW988_RS09350	COG0017	Asparaginyl-tRNA synthetase
HW988_RS09370	COG0625	glutathione transferase activity
HW988_RS09375	COG0037	tRNA processing
HW988_RS09390	COG3034	peptidoglycan biosynthetic process
HW988_RS09405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW988_RS09415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW988_RS09435	COG1837	Belongs to the UPF0109 family
HW988_RS09495	COG0018	arginyl-trna synthetase
HW988_RS09505	COG0582	viral genome integration into host DNA
HW988_RS09520	COG1116	anion transmembrane transporter activity
HW988_RS09525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW988_RS09540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HW988_RS09545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW988_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS09560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW988_RS09565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW988_RS09570	COG0698	ribose 5-phosphate isomerase
HW988_RS09575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HW988_RS09600	COG3158	transport of potassium into the cell
HW988_RS09610	COG0431	NADPH-dependent FMN reductase
HW988_RS09625	COG0811	peptide transport
HW988_RS09630	COG0848	biopolymer transport protein
HW988_RS09685	COG1242	4 iron, 4 sulfur cluster binding
HW988_RS09690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW988_RS09690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW988_RS09695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW988_RS09720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW988_RS09725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HW988_RS09730	COG1994	Peptidase M50
HW988_RS09735	COG1960	acyl-CoA dehydrogenase activity
HW988_RS09745	COG5001	Diguanylate cyclase
HW988_RS09745	COG1716	ATPase activity
HW988_RS09765	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS09775	COG1187	pseudouridine synthase activity
HW988_RS09810	COG0217	transcriptional regulatory protein
HW988_RS09820	COG2166	iron-sulfur cluster assembly
HW988_RS09845	COG2814	Major facilitator Superfamily
HW988_RS09855	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HW988_RS09860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HW988_RS09870	COG0840	transmembrane signaling receptor activity
HW988_RS09875	COG0745	RESPONSE REGULATOR receiver
HW988_RS09895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW988_RS09900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW988_RS09910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW988_RS09920	COG0386	Belongs to the glutathione peroxidase family
HW988_RS09930	COG0733	neurotransmitter:sodium symporter activity
HW988_RS09935	COG1160	GTP binding
HW988_RS09945	COG0571	ribonuclease III activity
HW988_RS09950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW988_RS09955	COG0482	sulfurtransferase activity
HW988_RS09960	COG1104	cysteine desulfurase activity
HW988_RS09975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW988_RS09980	COG0802	atpase or kinase
HW988_RS09985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HW988_RS09990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW988_RS10000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HW988_RS10005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW988_RS10010	COG0037	tRNA processing
HW988_RS10015	COG1012	belongs to the aldehyde dehydrogenase family
HW988_RS10035	COG0745	RESPONSE REGULATOR receiver
HW988_RS10055	COG1494	fructose-1,6-bisphosphatase
HW988_RS10060	COG0824	Thioesterase
HW988_RS10065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW988_RS10080	COG0471	metal ion transport
HW988_RS10115	COG1649	PFAM Uncharacterised BCR, COG1649
HW988_RS10115	COG0726	polysaccharide deacetylase
HW988_RS10120	COG1215	transferase activity, transferring glycosyl groups
HW988_RS10225	COG1999	signal sequence binding
HW988_RS10235	COG0842	Transport permease protein
HW988_RS10240	COG1129	ABC transporter
HW988_RS10240	COG0842	Transport permease protein
HW988_RS10245	COG1131	(ABC) transporter
HW988_RS10250	COG1131	(ABC) transporter
HW988_RS10255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW988_RS10265	COG0840	transmembrane signaling receptor activity
HW988_RS10270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW988_RS10305	COG0720	synthase
HW988_RS10320	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HW988_RS10355	COG1703	isobutyryl-CoA mutase activity
HW988_RS10355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW988_RS10355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW988_RS10360	COG1024	Enoyl-CoA hydratase
HW988_RS10365	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW988_RS10385	COG1404	Belongs to the peptidase S8 family
HW988_RS10395	COG0784	Response regulator, receiver
HW988_RS10395	COG2198	Histidine kinase
HW988_RS10395	COG5002	protein histidine kinase activity
HW988_RS10435	COG3104	oligopeptide transport
HW988_RS10440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HW988_RS10445	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HW988_RS10450	COG3387	PFAM Glycoside hydrolase 15-related
HW988_RS10470	COG1024	Enoyl-CoA hydratase
HW988_RS10470	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW988_RS10485	COG0280	phosphate acetyltransferase
HW988_RS10485	COG0281	malic enzyme
HW988_RS10495	COG3459	Glycosyltransferase 36 associated
HW988_RS10500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW988_RS10520	COG1607	acyl-coa hydrolase
HW988_RS10525	COG2197	response regulator
HW988_RS10555	COG0617	tRNA 3'-terminal CCA addition
HW988_RS10575	COG0038	chloride channel
HW988_RS10580	COG2900	Belongs to the SlyX family
HW988_RS10610	COG3483	tryptophan 2,3-dioxygenase activity
HW988_RS10615	COG0326	Molecular chaperone. Has ATPase activity
HW988_RS10625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW988_RS10635	COG0318	PFAM AMP-dependent synthetase and ligase
HW988_RS10650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HW988_RS10710	COG1733	regulation of RNA biosynthetic process
HW988_RS10715	COG0778	Nitroreductase
HW988_RS10720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW988_RS10755	COG0477	Major facilitator Superfamily
HW988_RS10770	COG0443	Heat shock 70 kDa protein
HW988_RS10790	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HW988_RS10790	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HW988_RS10815	COG0038	chloride channel
HW988_RS10840	COG0730	response to heat
HW988_RS10850	COG2814	Major facilitator Superfamily
HW988_RS10865	COG1418	mRNA catabolic process
HW988_RS10875	COG1253	flavin adenine dinucleotide binding
HW988_RS10915	COG1960	acyl-CoA dehydrogenase activity
HW988_RS10925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW988_RS10950	COG0625	glutathione transferase activity
HW988_RS10985	COG0583	DNA-binding transcription factor activity
HW988_RS11015	COG0616	signal peptide processing
HW988_RS11020	COG0444	Belongs to the ABC transporter superfamily
HW988_RS11025	COG4608	Belongs to the ABC transporter superfamily
HW988_RS11030	COG4166	transmembrane transport
HW988_RS11035	COG0601	transmembrane transport
HW988_RS11040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW988_RS11050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW988_RS11055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW988_RS11060	COG0584	glycerophosphoryl diester phosphodiesterase
HW988_RS11070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW988_RS11085	COG0189	ligase activity
HW988_RS11090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW988_RS11110	COG1720	tRNA m6t6A37 methyltransferase activity
HW988_RS11115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HW988_RS11125	COG2814	Major facilitator Superfamily
HW988_RS11140	COG0288	reversible hydration of carbon dioxide
HW988_RS11155	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HW988_RS11160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HW988_RS11165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HW988_RS11170	COG0387	Pfam Sodium calcium exchanger
HW988_RS11175	COG1012	belongs to the aldehyde dehydrogenase family
HW988_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS11270	COG1012	belongs to the aldehyde dehydrogenase family
HW988_RS11275	COG0475	glutathione-regulated potassium exporter activity
HW988_RS11285	COG1404	Belongs to the peptidase S8 family
HW988_RS11310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW988_RS11325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW988_RS11345	COG3278	Belongs to the heme-copper respiratory oxidase family
HW988_RS11355	COG2010	Cytochrome c
HW988_RS11360	COG0348	domain, Protein
HW988_RS11385	COG0328	RNA-DNA hybrid ribonuclease activity
HW988_RS11390	COG2814	Major facilitator Superfamily
HW988_RS11405	COG2205	protein histidine kinase activity
HW988_RS11405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW988_RS11415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW988_RS11430	COG0545	Peptidyl-prolyl cis-trans isomerase
HW988_RS11435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW988_RS11450	COG4974	Belongs to the 'phage' integrase family
HW988_RS11475	COG2385	sporulation resulting in formation of a cellular spore
HW988_RS11505	COG0728	peptidoglycan biosynthetic process
HW988_RS11510	COG0322	excinuclease ABC activity
HW988_RS11515	COG0556	nucleotide-excision repair
HW988_RS11530	COG0215	cysteine-tRNA ligase activity
HW988_RS11535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW988_RS11545	COG1404	Belongs to the peptidase S8 family
HW988_RS11570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW988_RS11590	COG0784	Response regulator, receiver
HW988_RS11590	COG2205	protein histidine kinase activity
HW988_RS11605	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HW988_RS11610	COG1830	Aldolase
HW988_RS11620	COG0534	Mate efflux family protein
HW988_RS11660	COG0633	Ferredoxin
HW988_RS11660	COG3217	Mosc domain protein beta barrel domain protein
HW988_RS11675	COG2951	lytic endotransglycosylase activity
HW988_RS11680	COG0477	Major facilitator Superfamily
HW988_RS11695	COG4106	trans-aconitate 2-methyltransferase activity
HW988_RS11700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW988_RS11705	COG0084	hydrolase, TatD family'
HW988_RS11720	COG0586	Pfam SNARE associated Golgi protein
HW988_RS11725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW988_RS11725	COG0564	pseudouridine synthase activity
HW988_RS11745	COG0116	Belongs to the methyltransferase superfamily
HW988_RS11765	COG0859	PFAM glycosyl transferase family 9
HW988_RS11815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW988_RS11830	COG2201	protein-glutamate methylesterase activity
HW988_RS11870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW988_RS11905	COG0784	Response regulator, receiver
HW988_RS11905	COG3437	response regulator, receiver
HW988_RS11925	COG2871	sodium ion transport
HW988_RS11940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW988_RS11960	COG1469	GTP cyclohydrolase I activity
HW988_RS11965	COG0424	maF-like protein
HW988_RS11970	COG0295	cytidine deaminase activity
HW988_RS12025	COG1792	Involved in formation and maintenance of cell shape
HW988_RS12035	COG0768	penicillin binding
HW988_RS12040	COG0772	Belongs to the SEDS family
HW988_RS12060	COG0789	Transcriptional regulator
HW988_RS12065	COG0741	lytic transglycosylase activity
HW988_RS12095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HW988_RS12095	COG0758	DNA mediated transformation
HW988_RS12145	COG4264	IucA IucC family
HW988_RS12175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HW988_RS12185	COG2255	four-way junction helicase activity
HW988_RS12190	COG0632	four-way junction helicase activity
HW988_RS12195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HW988_RS12205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW988_RS12250	COG2079	MmgE PrpD family protein
HW988_RS12255	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HW988_RS12275	COG1522	sequence-specific DNA binding
HW988_RS12300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW988_RS12315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HW988_RS12420	COG0840	transmembrane signaling receptor activity
HW988_RS12435	COG1289	transmembrane transporter activity
HW988_RS12445	COG0308	aminopeptidase N
HW988_RS12465	COG0302	gtp cyclohydrolase
HW988_RS12540	COG1132	(ABC) transporter
HW988_RS12545	COG1132	(ABC) transporter
HW988_RS12550	COG2239	Acts as a magnesium transporter
HW988_RS12600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW988_RS12610	COG2967	ApaG domain
HW988_RS12680	COG0259	pyridoxamine-phosphate oxidase activity
HW988_RS12685	COG0545	Peptidyl-prolyl cis-trans isomerase
HW988_RS12700	COG0745	RESPONSE REGULATOR receiver
HW988_RS12705	COG2205	protein histidine kinase activity
HW988_RS12735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW988_RS12740	COG2885	chlorophyll binding
HW988_RS12750	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HW988_RS12760	COG0783	Belongs to the Dps family
HW988_RS12775	COG0745	RESPONSE REGULATOR receiver
HW988_RS12780	COG5002	protein histidine kinase activity
HW988_RS12780	COG3850	Histidine kinase
HW988_RS12850	COG0840	transmembrane signaling receptor activity
HW988_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
HW988_RS12880	COG0572	uridine kinase
HW988_RS12885	COG0531	amino acid
HW988_RS12900	COG2824	Alkylphosphonate utilization operon protein PhnA
HW988_RS12925	COG0484	heat shock protein binding
HW988_RS12935	COG4968	Prepilin-type N-terminal cleavage methylation domain
HW988_RS12940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HW988_RS12990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HW988_RS13065	COG0473	3-isopropylmalate dehydrogenase activity
HW988_RS13080	COG2205	protein histidine kinase activity
HW988_RS13085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HW988_RS13095	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW988_RS13100	COG1012	belongs to the aldehyde dehydrogenase family
HW988_RS13105	COG1047	Peptidyl-prolyl cis-trans
HW988_RS13110	COG0724	RNA recognition motif
HW988_RS13175	COG5640	endopeptidase activity
HW988_RS13190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW988_RS13195	COG1741	Belongs to the pirin family
HW988_RS13235	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS13255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW988_RS13260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW988_RS13275	COG2813	Specifically methylates the guanine in position
HW988_RS13285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW988_RS13290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HW988_RS13315	COG2986	histidine ammonia-lyase
HW988_RS13325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW988_RS13330	COG1704	LemA family
HW988_RS13335	COG0116	Belongs to the methyltransferase superfamily
HW988_RS13335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW988_RS13345	COG5599	Phosphatase
HW988_RS13355	COG1960	acyl-CoA dehydrogenase activity
HW988_RS13360	COG1058	Belongs to the CinA family
HW988_RS13360	COG1546	Belongs to the CinA family
HW988_RS13370	COG2814	Major facilitator Superfamily
HW988_RS13375	COG0539	negative regulation of cytoplasmic translation
HW988_RS13375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HW988_RS13380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW988_RS13390	COG1104	cysteine desulfurase activity
HW988_RS13410	COG0596	Alpha beta hydrolase
HW988_RS13420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HW988_RS13425	COG1418	mRNA catabolic process
HW988_RS13430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW988_RS13435	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HW988_RS13465	COG0702	epimerase
HW988_RS13470	COG0552	protein localization to endoplasmic reticulum
HW988_RS13475	COG0840	transmembrane signaling receptor activity
HW988_RS13505	COG1959	2 iron, 2 sulfur cluster binding
HW988_RS13520	COG1132	(ABC) transporter
HW988_RS13545	COG0583	DNA-binding transcription factor activity
HW988_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
HW988_RS13600	COG0574	Belongs to the PEP-utilizing enzyme family
HW988_RS13600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW988_RS13625	COG0423	glycine-tRNA ligase activity
HW988_RS13645	COG0489	protein tyrosine kinase activity
HW988_RS13685	COG0791	NLP P60 protein
HW988_RS13685	COG1388	LysM domain
HW988_RS13750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW988_RS13760	COG4181	ATPase activity
HW988_RS13775	COG0124	histidyl-tRNA synthetase
HW988_RS13785	COG1404	Belongs to the peptidase S8 family
HW988_RS13800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HW988_RS13825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW988_RS13825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW988_RS13835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW988_RS13840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW988_RS13855	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HW988_RS13870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW988_RS13880	COG0840	transmembrane signaling receptor activity
HW988_RS13885	COG0583	DNA-binding transcription factor activity
HW988_RS13900	COG0612	Peptidase, M16
HW988_RS13905	COG1580	Controls the rotational direction of flagella during chemotaxis
HW988_RS13940	COG0616	signal peptide processing
HW988_RS13990	COG0583	DNA-binding transcription factor activity
HW988_RS13995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HW988_RS14000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW988_RS14015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW988_RS14030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW988_RS14045	COG0149	triose-phosphate isomerase activity
HW988_RS14050	COG0126	phosphoglycerate kinase activity
HW988_RS14065	COG1272	protein, Hemolysin III
HW988_RS14075	COG0084	hydrolase, TatD family'
HW988_RS14080	COG0470	DNA polymerase III
HW988_RS14085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW988_RS14140	COG0598	Magnesium transport protein CorA
HW988_RS14145	COG4106	trans-aconitate 2-methyltransferase activity
HW988_RS14195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW988_RS14195	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HW988_RS14205	COG2205	protein histidine kinase activity
HW988_RS14205	COG2198	Histidine kinase
HW988_RS14205	COG0784	Response regulator, receiver
HW988_RS14210	COG5002	protein histidine kinase activity
HW988_RS14215	COG0745	RESPONSE REGULATOR receiver
HW988_RS14220	COG0704	Plays a role in the regulation of phosphate uptake
HW988_RS14230	COG0248	Ppx GppA phosphatase
HW988_RS14245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HW988_RS14250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HW988_RS14265	COG2353	YceI-like domain
HW988_RS14270	COG3384	dioxygenase
HW988_RS14280	COG1116	anion transmembrane transporter activity
HW988_RS14310	COG0488	(ABC) transporter
HW988_RS14315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HW988_RS14325	COG0514	ATP-dependent DNA helicase (RecQ)
HW988_RS14330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW988_RS14395	COG1253	flavin adenine dinucleotide binding
HW988_RS14400	COG1324	tolerance protein
HW988_RS14405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HW988_RS14495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HW988_RS14495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW988_RS14510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW988_RS14525	COG0312	modulator of DNA gyrase
HW988_RS14530	COG0312	modulator of DNA gyrase
HW988_RS14550	COG0693	protein deglycase activity
HW988_RS14570	COG2183	response to ionizing radiation
HW988_RS14575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW988_RS14585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HW988_RS14595	COG0840	transmembrane signaling receptor activity
HW988_RS14605	COG3437	response regulator, receiver
HW988_RS14605	COG2205	protein histidine kinase activity
HW988_RS14605	COG4999	Histidine kinase
HW988_RS14605	COG3850	Histidine kinase
HW988_RS14615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW988_RS14615	COG0116	Belongs to the methyltransferase superfamily
HW988_RS14620	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HW988_RS14620	COG0644	oxidoreductase
HW988_RS14630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW988_RS14640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HW988_RS14645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW988_RS14650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW988_RS14690	COG0473	3-isopropylmalate dehydrogenase activity
HW988_RS14695	COG0583	DNA-binding transcription factor activity
HW988_RS14715	COG0840	transmembrane signaling receptor activity
HW988_RS14715	COG3290	protein histidine kinase activity
HW988_RS14720	COG0840	transmembrane signaling receptor activity
HW988_RS14730	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW988_RS14750	COG1858	cytochrome C peroxidase
HW988_RS14760	COG2204	response regulator
HW988_RS14770	COG4191	Histidine kinase
HW988_RS14795	COG0784	Response regulator, receiver
HW988_RS14795	COG2205	protein histidine kinase activity
HW988_RS14825	COG0252	asparaginase activity
HW988_RS14835	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW988_RS14870	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HW988_RS14875	COG2267	carboxylic ester hydrolase activity
HW988_RS14880	COG0583	DNA-binding transcription factor activity
HW988_RS14920	COG0745	RESPONSE REGULATOR receiver
HW988_RS14925	COG0784	Response regulator, receiver
HW988_RS14925	COG2205	protein histidine kinase activity
HW988_RS14925	COG5002	protein histidine kinase activity
HW988_RS14950	COG2154	pterin-4-alpha-carbinolamine dehydratase
HW988_RS14960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW988_RS14975	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW988_RS14995	COG2885	chlorophyll binding
HW988_RS15055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW988_RS15105	COG1131	(ABC) transporter
HW988_RS15115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HW988_RS15135	COG0681	Belongs to the peptidase S26 family
HW988_RS15145	COG0681	Belongs to the peptidase S26 family
HW988_RS15150	COG0681	Belongs to the peptidase S26 family
HW988_RS15155	COG0481	GTPase activity
HW988_RS15160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW988_RS15180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW988_RS15210	COG0811	peptide transport
HW988_RS15250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HW988_RS15260	COG0517	IMP dehydrogenase activity
HW988_RS15260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW988_RS15265	COG0504	CTP synthase activity
HW988_RS15270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HW988_RS15275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HW988_RS15280	COG2204	response regulator
HW988_RS15295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW988_RS15295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW988_RS15310	COG0148	phosphopyruvate hydratase activity
HW988_RS15340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW988_RS15340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HW988_RS15420	COG4254	PFAM FecR protein
HW988_RS15490	COG1489	DNA binding
HW988_RS15515	COG0183	Belongs to the thiolase family
HW988_RS15545	COG2030	dehydratase
HW988_RS15550	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HW988_RS15565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW988_RS15650	COG1175	transmembrane transport
HW988_RS15655	COG3833	ABC-type maltose transport systems, permease component
HW988_RS15660	COG3842	ATPase activity
HW988_RS15670	COG1940	carbohydrate kinase activity
HW988_RS15680	COG0166	Belongs to the GPI family
HW988_RS15695	COG1846	Transcriptional regulator
HW988_RS15700	COG1764	response to oxidative stress
HW988_RS15710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HW988_RS15730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HW988_RS15730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HW988_RS15755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW988_RS15760	COG0167	dihydroorotate dehydrogenase activity
HW988_RS15765	COG0494	nUDIX hydrolase
HW988_RS15780	COG0776	regulation of translation
HW988_RS15785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HW988_RS15800	COG0312	modulator of DNA gyrase
HW988_RS15830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW988_RS15830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW988_RS15850	COG2264	protein methyltransferase activity
HW988_RS15950	COG0509	glycine decarboxylation via glycine cleavage system
HW988_RS15955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW988_RS15995	COG5002	protein histidine kinase activity
HW988_RS16005	COG2205	protein histidine kinase activity
HW988_RS16005	COG0784	Response regulator, receiver
HW988_RS16005	COG5002	protein histidine kinase activity
HW988_RS16010	COG1490	D-aminoacyl-tRNA deacylase activity
HW988_RS16055	COG3876	Protein conserved in bacteria
HW988_RS16090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW988_RS16120	COG2843	Capsule synthesis protein
HW988_RS16140	COG0513	Belongs to the DEAD box helicase family
HW988_RS16145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW988_RS16160	COG1272	protein, Hemolysin III
HW988_RS16170	COG0494	nUDIX hydrolase
HW988_RS16185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HW988_RS16185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HW988_RS16190	COG0024	Methionine aminopeptidase
HW988_RS16210	COG2814	Major facilitator Superfamily
HW988_RS16225	COG1846	Transcriptional regulator
HW988_RS16240	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HW988_RS16280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HW988_RS16285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW988_RS16290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HW988_RS16305	COG2885	chlorophyll binding
HW988_RS16360	COG2204	response regulator
HW988_RS16365	COG4964	Belongs to the GSP D family
HW988_RS16390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW988_RS16400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW988_RS16415	COG1191	sigma factor activity
HW988_RS16430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW988_RS16435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW988_RS16440	COG1684	flagellar biosynthetic protein fliR
HW988_RS16445	COG1987	bacterial-type flagellum assembly
HW988_RS16450	COG1338	Plays a role in the flagellum-specific transport system
HW988_RS16460	COG1776	CheC inhibitor of MCP methylation
HW988_RS16460	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW988_RS16510	COG0210	DNA helicase
HW988_RS16560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW988_RS16565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW988_RS16580	COG2205	protein histidine kinase activity
HW988_RS16595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW988_RS16610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HW988_RS16625	COG0803	Belongs to the bacterial solute-binding protein 9 family
HW988_RS16630	COG1121	(ABC) transporter
HW988_RS16655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HW988_RS16665	COG0205	6-phosphofructokinase activity
HW988_RS16700	COG2205	protein histidine kinase activity
HW988_RS16705	COG0745	RESPONSE REGULATOR receiver
HW988_RS16720	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW988_RS16740	COG1157	protein secretion by the type III secretion system
HW988_RS16750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW988_RS16760	COG1677	Flagellar hook-basal body complex protein FliE
HW988_RS16770	COG1815	bacterial-type flagellum-dependent cell motility
HW988_RS16775	COG2204	response regulator
HW988_RS16790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW988_RS16795	COG1127	ABC transporter
HW988_RS16820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HW988_RS16835	COG1435	thymidine kinase activity
HW988_RS16840	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HW988_RS16850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW988_RS16855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW988_RS16880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW988_RS16925	COG0113	porphobilinogen synthase activity
HW988_RS16935	COG0181	hydroxymethylbilane synthase activity
HW988_RS16940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW988_RS16950	COG0745	RESPONSE REGULATOR receiver
HW988_RS16960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW988_RS16970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW988_RS16995	COG2945	thiolester hydrolase activity
HW988_RS16995	COG0596	Alpha beta hydrolase
HW988_RS17000	COG0617	tRNA 3'-terminal CCA addition
HW988_RS17005	COG5002	protein histidine kinase activity
HW988_RS17005	COG2198	Histidine kinase
HW988_RS17005	COG0784	Response regulator, receiver
HW988_RS17010	COG2201	protein-glutamate methylesterase activity
HW988_RS17015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW988_RS17020	COG2198	Histidine kinase
HW988_RS17020	COG0643	Histidine kinase
HW988_RS17025	COG0835	chemotaxis
HW988_RS17040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HW988_RS17045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HW988_RS17070	COG0596	Alpha beta hydrolase
HW988_RS17075	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HW988_RS17085	COG1605	Chorismate mutase
HW988_RS17085	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HW988_RS17090	COG2226	methyltransferase
HW988_RS17105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW988_RS17120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HW988_RS17125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW988_RS17135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW988_RS17145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HW988_RS17175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW988_RS17200	COG1309	transcriptional regulator
HW988_RS17220	COG0708	Exodeoxyribonuclease III
HW988_RS17245	COG0793	Belongs to the peptidase S41A family
HW988_RS17250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW988_RS17285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW988_RS17295	COG2897	thiosulfate sulfurtransferase activity
HW988_RS17330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HW988_RS17335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HW988_RS17345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HW988_RS17350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HW988_RS17370	COG1683	Conserved Protein
HW988_RS17375	COG0488	(ABC) transporter
HW988_RS17390	COG0488	(ABC) transporter
HW988_RS17415	COG0439	Biotin carboxylase
HW988_RS17425	COG1024	Enoyl-CoA hydratase
HW988_RS17430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW988_RS17460	COG4555	ABC transporter
HW988_RS17490	COG0415	Belongs to the DNA photolyase family
HW988_RS17515	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW988_RS17545	COG0583	DNA-binding transcription factor activity
HW988_RS17555	COG2234	aminopeptidase activity
HW988_RS17570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW988_RS17585	COG0517	IMP dehydrogenase activity
HW988_RS17595	COG0702	epimerase
HW988_RS17600	COG0514	ATP-dependent DNA helicase (RecQ)
HW988_RS17605	COG0667	Aldo Keto reductase
HW988_RS17630	COG0488	(ABC) transporter
HW988_RS17690	COG0583	DNA-binding transcription factor activity
HW988_RS17695	COG1335	isochorismatase
HW988_RS17700	COG1228	amidohydrolase
HW988_RS17705	COG1741	Belongs to the pirin family
HW988_RS17725	COG0840	transmembrane signaling receptor activity
HW988_RS17730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW988_RS17745	COG0708	Exodeoxyribonuclease III
HW988_RS17750	COG0702	epimerase
HW988_RS17755	COG1733	regulation of RNA biosynthetic process
HW988_RS17785	COG0071	Belongs to the small heat shock protein (HSP20) family
HW988_RS17795	COG2373	Large extracellular alpha-helical protein
HW988_RS17800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW988_RS17820	COG1215	transferase activity, transferring glycosyl groups
HW988_RS17865	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HW988_RS17880	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HW988_RS17910	COG0640	Transcriptional regulator
HW988_RS17945	COG1002	Type II restriction enzyme, methylase subunits
HW988_RS17990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW988_RS18005	COG0538	isocitrate dehydrogenase activity
HW988_RS18015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW988_RS18020	COG3958	Transketolase
HW988_RS18025	COG3959	Transketolase, thiamine diphosphate binding domain
HW988_RS18045	COG0463	Glycosyl transferase, family 2
HW988_RS18060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW988_RS18120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW988_RS18125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HW988_RS18130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW988_RS18135	COG1100	Small GTP-binding protein
HW988_RS18140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HW988_RS18195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HW988_RS18200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HW988_RS18220	COG3852	Histidine kinase
HW988_RS18225	COG2204	response regulator
HW988_RS18235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HW988_RS18240	COG0740	serine-type endopeptidase activity
HW988_RS18245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW988_RS18250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW988_RS18285	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW988_RS18295	COG0596	Alpha beta hydrolase
HW988_RS18305	COG0793	Belongs to the peptidase S41A family
HW988_RS18320	COG2884	Cell division ATP-binding protein ftsE
HW988_RS18335	COG1970	mechanosensitive ion channel activity
HW988_RS18355	COG1132	(ABC) transporter
HW988_RS18380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW988_RS18405	COG1472	Belongs to the glycosyl hydrolase 3 family
HW988_RS18430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW988_RS18440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW988_RS18455	COG0052	Belongs to the universal ribosomal protein uS2 family
HW988_RS18460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HW988_RS18465	COG0528	UMP kinase activity
HW988_RS18470	COG0233	cytoplasmic translational termination
HW988_RS18475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW988_RS18485	COG0750	zinc metalloprotease
HW988_RS18490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HW988_RS18505	COG0564	pseudouridine synthase activity
HW988_RS18515	COG2094	Belongs to the DNA glycosylase MPG family
HW988_RS18520	COG0783	Belongs to the Dps family
HW988_RS18530	COG0626	cystathionine gamma-synthase activity
HW988_RS18565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW988_RS18575	COG1127	ABC transporter
HW988_RS18580	COG1127	ABC transporter
HW988_RS18585	COG0045	succinate-CoA ligase (ADP-forming) activity
HW988_RS18590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW988_RS18620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW988_RS18625	COG2942	2-epimerase
HW988_RS18635	COG0105	UTP biosynthetic process
HW988_RS18640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW988_RS18650	COG1426	Protein conserved in bacteria
HW988_RS18665	COG2871	sodium ion transport
HW988_RS18670	COG2176	DNA-directed DNA polymerase activity
HW988_RS18675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW988_RS18675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HW988_RS18695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW988_RS18715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HW988_RS18720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW988_RS18725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW988_RS18730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HW988_RS18735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HW988_RS18745	COG1530	ribonuclease E activity
HW988_RS18755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HW988_RS18780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW988_RS18785	COG0439	Biotin carboxylase
HW988_RS18795	COG0805	protein transport
HW988_RS18800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW988_RS18810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HW988_RS18820	COG0612	Peptidase, M16
HW988_RS18825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW988_RS18830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW988_RS18835	COG0484	heat shock protein binding
HW988_RS18855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW988_RS18900	COG1007	ATP synthesis coupled electron transport
HW988_RS18915	COG0713	ATP synthesis coupled electron transport
HW988_RS18925	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HW988_RS18930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW988_RS18945	COG1472	Belongs to the glycosyl hydrolase 3 family
HW988_RS18950	COG0322	excinuclease ABC activity
HW988_RS18955	COG1199	ATP-dependent helicase activity
HW988_RS18955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW988_RS18965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HW988_RS18970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW988_RS18975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW988_RS18980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HW988_RS18985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW988_RS18990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW988_RS19010	COG1192	Involved in chromosome partitioning
HW988_RS19020	COG0357	Ribosomal RNA small subunit methyltransferase G
HW988_RS19025	COG0445	tRNA wobble uridine modification
HW988_RS19030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HW988_RS19040	COG0706	membrane insertase activity
HW988_RS19045	COG0759	Could be involved in insertion of integral membrane proteins into the membrane