locus-tag	class	description
DOE51_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DOE51_RS00020	COG0187	DNA topoisomerase II activity
DOE51_RS00045	COG0356	it plays a direct role in the translocation of protons across the membrane
DOE51_RS00050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOE51_RS00060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DOE51_RS00070	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DOE51_RS00080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOE51_RS00085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOE51_RS00095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DOE51_RS00100	COG2086	electron transfer activity
DOE51_RS00110	COG1053	succinate dehydrogenase
DOE51_RS00170	COG0360	Binds together with S18 to 16S ribosomal RNA
DOE51_RS00180	COG0359	binds to the 23S rRNA
DOE51_RS00195	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS00200	COG0305	Participates in initiation and elongation during chromosome replication
DOE51_RS00210	COG0602	queuosine metabolic process
DOE51_RS00215	COG1674	ftsk spoiiie
DOE51_RS00235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DOE51_RS00240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DOE51_RS00245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DOE51_RS00255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DOE51_RS00285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DOE51_RS00295	COG0154	amidase activity
DOE51_RS00300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DOE51_RS00305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DOE51_RS00305	COG0248	Ppx GppA phosphatase
DOE51_RS00325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DOE51_RS00340	COG0254	rRNA binding
DOE51_RS00345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DOE51_RS00350	COG2890	protein-(glutamine-N5) methyltransferase activity
DOE51_RS00355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DOE51_RS00375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DOE51_RS00400	COG0586	Pfam SNARE associated Golgi protein
DOE51_RS00410	COG0590	tRNA wobble adenosine to inosine editing
DOE51_RS00420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DOE51_RS00425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DOE51_RS00430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DOE51_RS00435	COG2224	Isocitrate lyase
DOE51_RS00460	COG2267	carboxylic ester hydrolase activity
DOE51_RS00500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DOE51_RS00505	COG0459	protein refolding
DOE51_RS00525	COG2201	protein-glutamate methylesterase activity
DOE51_RS00605	COG0840	transmembrane signaling receptor activity
DOE51_RS00610	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DOE51_RS00620	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DOE51_RS00640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DOE51_RS00645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOE51_RS00655	COG1012	belongs to the aldehyde dehydrogenase family
DOE51_RS00660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DOE51_RS00670	COG0527	aspartate kinase activity
DOE51_RS00685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOE51_RS00690	COG1217	gtp-binding protein TYPA
DOE51_RS00695	COG1131	(ABC) transporter
DOE51_RS00705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE51_RS00710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE51_RS00715	COG0671	phosphoesterase, PA-phosphatase related
DOE51_RS00720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DOE51_RS00760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOE51_RS00770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DOE51_RS00780	COG0823	Involved in the tonB-independent uptake of proteins
DOE51_RS00790	COG0848	biopolymer transport protein
DOE51_RS00815	COG0719	Fe-S assembly protein
DOE51_RS00820	COG0396	ATPase activity
DOE51_RS00825	COG0719	Fe-S assembly protein
DOE51_RS00830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DOE51_RS00855	COG1570	exodeoxyribonuclease VII activity
DOE51_RS00860	COG1722	exodeoxyribonuclease VII activity
DOE51_RS00865	COG0142	geranyltranstransferase activity
DOE51_RS00870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DOE51_RS00880	COG0006	proline dipeptidase activity
DOE51_RS00895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DOE51_RS00910	COG1077	Cell shape determining protein MreB Mrl
DOE51_RS00960	COG2003	Belongs to the UPF0758 family
DOE51_RS00975	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DOE51_RS01005	COG2766	serine protein kinase
DOE51_RS01010	COG2718	Belongs to the UPF0229 family
DOE51_RS01015	COG2719	SpoVR family
DOE51_RS01040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DOE51_RS01045	COG1610	YqeY-like protein
DOE51_RS01050	COG0358	DNA primase activity
DOE51_RS01070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DOE51_RS01075	COG1959	2 iron, 2 sulfur cluster binding
DOE51_RS01080	COG0724	RNA recognition motif
DOE51_RS01115	COG2205	protein histidine kinase activity
DOE51_RS01115	COG2198	Histidine kinase
DOE51_RS01115	COG0784	Response regulator, receiver
DOE51_RS01135	COG3237	CsbD-like
DOE51_RS01150	COG0783	Belongs to the Dps family
DOE51_RS01160	COG1295	ribonuclease BN
DOE51_RS01170	COG1064	alcohol dehydrogenase
DOE51_RS01180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOE51_RS01190	COG0509	glycine decarboxylation via glycine cleavage system
DOE51_RS01210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DOE51_RS01215	COG0653	protein targeting
DOE51_RS01245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOE51_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS01260	COG2267	carboxylic ester hydrolase activity
DOE51_RS01280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DOE51_RS01295	COG0109	protoheme IX farnesyltransferase activity
DOE51_RS01320	COG2032	superoxide dismutase activity
DOE51_RS01325	COG0783	Belongs to the Dps family
DOE51_RS01335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE51_RS01350	COG5002	protein histidine kinase activity
DOE51_RS01350	COG2205	protein histidine kinase activity
DOE51_RS01350	COG0784	Response regulator, receiver
DOE51_RS01360	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DOE51_RS01370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DOE51_RS01400	COG2863	cytochrome
DOE51_RS01405	COG2193	ferroxidase activity
DOE51_RS01410	COG0477	Major facilitator Superfamily
DOE51_RS01430	COG0006	proline dipeptidase activity
DOE51_RS01455	COG0357	Ribosomal RNA small subunit methyltransferase G
DOE51_RS01460	COG2814	Major facilitator Superfamily
DOE51_RS01475	COG0513	Belongs to the DEAD box helicase family
DOE51_RS01480	COG0017	Asparaginyl-tRNA synthetase
DOE51_RS01485	COG2207	Transcriptional regulator
DOE51_RS01490	COG1012	belongs to the aldehyde dehydrogenase family
DOE51_RS01535	COG0784	Response regulator, receiver
DOE51_RS01535	COG2205	protein histidine kinase activity
DOE51_RS01540	COG0513	Belongs to the DEAD box helicase family
DOE51_RS01565	COG2267	carboxylic ester hydrolase activity
DOE51_RS01590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DOE51_RS01600	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DOE51_RS01615	COG0667	Aldo Keto reductase
DOE51_RS01620	COG2207	Transcriptional regulator
DOE51_RS01645	COG0477	Major facilitator Superfamily
DOE51_RS01685	COG0210	DNA helicase
DOE51_RS01750	COG4245	von Willebrand factor, type A
DOE51_RS01755	COG0631	protein serine/threonine phosphatase activity
DOE51_RS01760	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
DOE51_RS01795	COG2223	nitrite transmembrane transporter activity
DOE51_RS01815	COG1047	Peptidyl-prolyl cis-trans
DOE51_RS01820	COG1666	GTP binding
DOE51_RS01825	COG0724	RNA recognition motif
DOE51_RS01835	COG4181	ATPase activity
DOE51_RS01840	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DOE51_RS01845	COG0009	L-threonylcarbamoyladenylate synthase
DOE51_RS01865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOE51_RS01875	COG1393	Belongs to the ArsC family
DOE51_RS01880	COG0010	Belongs to the arginase family
DOE51_RS01890	COG4174	ABC transporter (Permease)
DOE51_RS01895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOE51_RS01900	COG0840	transmembrane signaling receptor activity
DOE51_RS01910	COG1166	arginine decarboxylase activity
DOE51_RS01915	COG0495	leucyl-tRNA aminoacylation
DOE51_RS01925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DOE51_RS01930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DOE51_RS01940	COG0492	ferredoxin-NADP+ reductase activity
DOE51_RS01970	COG4608	Belongs to the ABC transporter superfamily
DOE51_RS01975	COG0444	Belongs to the ABC transporter superfamily
DOE51_RS01980	COG0546	phosphoglycolate phosphatase activity
DOE51_RS01995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DOE51_RS02000	COG5002	protein histidine kinase activity
DOE51_RS02010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOE51_RS02010	COG0574	Belongs to the PEP-utilizing enzyme family
DOE51_RS02015	COG0071	Belongs to the small heat shock protein (HSP20) family
DOE51_RS02020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DOE51_RS02035	COG1105	Belongs to the carbohydrate kinase PfkB family
DOE51_RS02040	COG0517	IMP dehydrogenase activity
DOE51_RS02060	COG0587	DNA-directed DNA polymerase activity
DOE51_RS02100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DOE51_RS02145	COG0631	protein serine/threonine phosphatase activity
DOE51_RS02150	COG0739	heme binding
DOE51_RS02170	COG0183	Belongs to the thiolase family
DOE51_RS02200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOE51_RS02205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOE51_RS02220	COG0583	DNA-binding transcription factor activity
DOE51_RS02230	COG0557	exoribonuclease II activity
DOE51_RS02300	COG1079	Belongs to the binding-protein-dependent transport system permease family
DOE51_RS02305	COG4603	Belongs to the binding-protein-dependent transport system permease family
DOE51_RS02310	COG3845	ABC transporter
DOE51_RS02315	COG1744	ABC transporter substrate-binding protein PnrA-like
DOE51_RS02320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE51_RS02375	COG0525	valine-tRNA ligase activity
DOE51_RS02400	COG1872	DUF167
DOE51_RS02415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DOE51_RS02430	COG0424	maF-like protein
DOE51_RS02455	COG1716	ATPase activity
DOE51_RS02510	COG1183	phosphatidylcholine synthase activity
DOE51_RS02515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DOE51_RS02530	COG0101	tRNA pseudouridine synthase activity
DOE51_RS02535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DOE51_RS02540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DOE51_RS02550	COG0784	Response regulator, receiver
DOE51_RS02550	COG2205	protein histidine kinase activity
DOE51_RS02560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DOE51_RS02565	COG2137	regulation of response to DNA damage stimulus
DOE51_RS02570	COG1408	metallophosphoesterase
DOE51_RS02575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DOE51_RS02595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DOE51_RS02600	COG1058	Belongs to the CinA family
DOE51_RS02600	COG1546	Belongs to the CinA family
DOE51_RS02605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DOE51_RS02620	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS02635	COG0386	Belongs to the glutathione peroxidase family
DOE51_RS02670	COG4786	Flagellar basal body rod
DOE51_RS02675	COG4786	Flagellar basal body rod
DOE51_RS02690	COG1706	bacterial-type flagellum-dependent cell motility
DOE51_RS02715	COG1749	Flagellar hook protein flgE
DOE51_RS02720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOE51_RS02730	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DOE51_RS02745	COG1575	Belongs to the MenA family. Type 1 subfamily
DOE51_RS02755	COG0318	PFAM AMP-dependent synthetase and ligase
DOE51_RS02770	COG0471	metal ion transport
DOE51_RS02780	COG0824	Thioesterase
DOE51_RS02785	COG0142	geranyltranstransferase activity
DOE51_RS02795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOE51_RS02830	COG0372	Belongs to the citrate synthase family
DOE51_RS02875	COG0643	Histidine kinase
DOE51_RS02875	COG2198	Histidine kinase
DOE51_RS02885	COG2201	protein-glutamate methylesterase activity
DOE51_RS02890	COG1012	belongs to the aldehyde dehydrogenase family
DOE51_RS02910	COG1181	Belongs to the D-alanine--D-alanine ligase family
DOE51_RS02915	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DOE51_RS02935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DOE51_RS02945	COG4143	(ABC) transporter
DOE51_RS02960	COG0784	Response regulator, receiver
DOE51_RS02960	COG5002	protein histidine kinase activity
DOE51_RS02960	COG2205	protein histidine kinase activity
DOE51_RS02965	COG0784	Response regulator, receiver
DOE51_RS02965	COG2205	protein histidine kinase activity
DOE51_RS02980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOE51_RS02990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOE51_RS02995	COG0693	protein deglycase activity
DOE51_RS03000	COG0723	plastoquinol--plastocyanin reductase activity
DOE51_RS03015	COG1516	flagellar protein fliS
DOE51_RS03040	COG0859	PFAM glycosyl transferase family 9
DOE51_RS03055	COG0745	RESPONSE REGULATOR receiver
DOE51_RS03060	COG0742	ribosomal rna small subunit methyltransferase
DOE51_RS03065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DOE51_RS03070	COG0436	Aminotransferase
DOE51_RS03080	COG0667	Aldo Keto reductase
DOE51_RS03105	COG4251	negative regulation of phosphorylation
DOE51_RS03110	COG1335	isochorismatase
DOE51_RS03115	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS03120	COG0583	DNA-binding transcription factor activity
DOE51_RS03135	COG2885	chlorophyll binding
DOE51_RS03150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DOE51_RS03155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DOE51_RS03160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DOE51_RS03190	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DOE51_RS03205	COG1846	Transcriptional regulator
DOE51_RS03220	COG2814	Major facilitator Superfamily
DOE51_RS03230	COG0024	Methionine aminopeptidase
DOE51_RS03240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DOE51_RS03240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DOE51_RS03260	COG1272	protein, Hemolysin III
DOE51_RS03275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DOE51_RS03280	COG0513	Belongs to the DEAD box helicase family
DOE51_RS03335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOE51_RS03415	COG0509	glycine decarboxylation via glycine cleavage system
DOE51_RS03420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DOE51_RS03455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DOE51_RS03455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DOE51_RS03485	COG0312	modulator of DNA gyrase
DOE51_RS03520	COG0776	regulation of translation
DOE51_RS03535	COG0494	nUDIX hydrolase
DOE51_RS03540	COG0167	dihydroorotate dehydrogenase activity
DOE51_RS03545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DOE51_RS03560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DOE51_RS03560	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DOE51_RS03575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DOE51_RS03590	COG1764	response to oxidative stress
DOE51_RS03595	COG1846	Transcriptional regulator
DOE51_RS03610	COG0166	Belongs to the GPI family
DOE51_RS03615	COG1940	carbohydrate kinase activity
DOE51_RS03630	COG3833	ABC-type maltose transport systems, permease component
DOE51_RS03635	COG1175	transmembrane transport
DOE51_RS03715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE51_RS03730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DOE51_RS03735	COG2030	dehydratase
DOE51_RS03760	COG0183	Belongs to the thiolase family
DOE51_RS03780	COG1489	DNA binding
DOE51_RS03805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DOE51_RS03805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DOE51_RS03835	COG0148	phosphopyruvate hydratase activity
DOE51_RS03850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOE51_RS03850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOE51_RS03855	COG2226	methyltransferase
DOE51_RS03870	COG2204	response regulator
DOE51_RS03875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DOE51_RS03880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DOE51_RS03885	COG0504	CTP synthase activity
DOE51_RS03890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DOE51_RS03890	COG0517	IMP dehydrogenase activity
DOE51_RS03925	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DOE51_RS03945	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DOE51_RS03990	COG0848	biopolymer transport protein
DOE51_RS04005	COG1137	ATPase activity
DOE51_RS04015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOE51_RS04045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DOE51_RS04050	COG0481	GTPase activity
DOE51_RS04055	COG0681	Belongs to the peptidase S26 family
DOE51_RS04085	COG0540	Belongs to the ATCase OTCase family
DOE51_RS04090	COG0505	Belongs to the CarA family
DOE51_RS04100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DOE51_RS04110	COG1131	(ABC) transporter
DOE51_RS04160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DOE51_RS04230	COG2814	Major facilitator Superfamily
DOE51_RS04245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DOE51_RS04255	COG5002	protein histidine kinase activity
DOE51_RS04255	COG0784	Response regulator, receiver
DOE51_RS04255	COG2205	protein histidine kinase activity
DOE51_RS04290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE51_RS04300	COG0252	asparaginase activity
DOE51_RS04305	COG1538	Outer membrane efflux protein
DOE51_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS04340	COG0628	permease
DOE51_RS04370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DOE51_RS04375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DOE51_RS04425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DOE51_RS04430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DOE51_RS04435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DOE51_RS04455	COG0644	oxidoreductase
DOE51_RS04455	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DOE51_RS04460	COG0116	Belongs to the methyltransferase superfamily
DOE51_RS04500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DOE51_RS04505	COG2183	response to ionizing radiation
DOE51_RS04525	COG0312	modulator of DNA gyrase
DOE51_RS04530	COG0312	modulator of DNA gyrase
DOE51_RS04535	COG2031	fatty acid transporter
DOE51_RS04540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DOE51_RS04550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DOE51_RS04565	COG0793	Belongs to the peptidase S41A family
DOE51_RS04600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DOE51_RS04605	COG1324	tolerance protein
DOE51_RS04610	COG1253	flavin adenine dinucleotide binding
DOE51_RS04635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DOE51_RS04640	COG0514	ATP-dependent DNA helicase (RecQ)
DOE51_RS04655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DOE51_RS04670	COG0726	polysaccharide deacetylase
DOE51_RS04675	COG0488	(ABC) transporter
DOE51_RS04695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOE51_RS04700	COG0709	Synthesizes selenophosphate from selenide and ATP
DOE51_RS04705	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DOE51_RS04725	COG3384	dioxygenase
DOE51_RS04750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DOE51_RS04755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DOE51_RS04765	COG0248	Ppx GppA phosphatase
DOE51_RS04775	COG0704	Plays a role in the regulation of phosphate uptake
DOE51_RS04780	COG0745	RESPONSE REGULATOR receiver
DOE51_RS04785	COG5002	protein histidine kinase activity
DOE51_RS04800	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DOE51_RS04800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DOE51_RS04855	COG4106	trans-aconitate 2-methyltransferase activity
DOE51_RS04860	COG0598	Magnesium transport protein CorA
DOE51_RS04900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DOE51_RS04910	COG0084	hydrolase, TatD family'
DOE51_RS04920	COG1272	protein, Hemolysin III
DOE51_RS04950	COG0126	phosphoglycerate kinase activity
DOE51_RS04955	COG0149	triose-phosphate isomerase activity
DOE51_RS04975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DOE51_RS04990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE51_RS05005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DOE51_RS05010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DOE51_RS05035	COG0616	signal peptide processing
DOE51_RS05065	COG0277	FAD linked oxidase domain protein
DOE51_RS05075	COG3386	PFAM SMP-30 Gluconolaconase
DOE51_RS05085	COG1580	Controls the rotational direction of flagella during chemotaxis
DOE51_RS05090	COG0612	Peptidase, M16
DOE51_RS05105	COG0583	DNA-binding transcription factor activity
DOE51_RS05110	COG0840	transmembrane signaling receptor activity
DOE51_RS05130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DOE51_RS05145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOE51_RS05150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DOE51_RS05160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DOE51_RS05160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOE51_RS05185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DOE51_RS05195	COG0124	histidyl-tRNA synthetase
DOE51_RS05210	COG4181	ATPase activity
DOE51_RS05220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DOE51_RS05275	COG0791	NLP P60 protein
DOE51_RS05275	COG1388	LysM domain
DOE51_RS05290	COG0840	transmembrane signaling receptor activity
DOE51_RS05300	COG0489	protein tyrosine kinase activity
DOE51_RS05330	COG0423	glycine-tRNA ligase activity
DOE51_RS05340	COG0840	transmembrane signaling receptor activity
DOE51_RS05350	COG0574	Belongs to the PEP-utilizing enzyme family
DOE51_RS05350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOE51_RS05370	COG1196	nuclear chromosome segregation
DOE51_RS05380	COG0346	lactoylglutathione lyase activity
DOE51_RS05385	COG1846	Transcriptional regulator
DOE51_RS05400	COG0778	Nitroreductase
DOE51_RS05405	COG1959	2 iron, 2 sulfur cluster binding
DOE51_RS05435	COG0552	protein localization to endoplasmic reticulum
DOE51_RS05440	COG0702	epimerase
DOE51_RS05465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DOE51_RS05470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DOE51_RS05475	COG1418	mRNA catabolic process
DOE51_RS05480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DOE51_RS05490	COG0596	Alpha beta hydrolase
DOE51_RS05500	COG1104	cysteine desulfurase activity
DOE51_RS05510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOE51_RS05515	COG0539	negative regulation of cytoplasmic translation
DOE51_RS05520	COG1058	Belongs to the CinA family
DOE51_RS05520	COG1546	Belongs to the CinA family
DOE51_RS05525	COG1960	acyl-CoA dehydrogenase activity
DOE51_RS05535	COG5599	Phosphatase
DOE51_RS05545	COG0840	transmembrane signaling receptor activity
DOE51_RS05550	COG0116	Belongs to the methyltransferase superfamily
DOE51_RS05550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOE51_RS05555	COG1704	LemA family
DOE51_RS05635	COG1741	Belongs to the pirin family
DOE51_RS05640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DOE51_RS05655	COG1794	racemase activity, acting on amino acids and derivatives
DOE51_RS05705	COG1012	belongs to the aldehyde dehydrogenase family
DOE51_RS05710	COG0179	Fumarylacetoacetate (FAA) hydrolase
DOE51_RS05720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DOE51_RS05725	COG2205	protein histidine kinase activity
DOE51_RS05740	COG0473	3-isopropylmalate dehydrogenase activity
DOE51_RS05790	COG3850	Histidine kinase
DOE51_RS05790	COG2205	protein histidine kinase activity
DOE51_RS05790	COG3437	response regulator, receiver
DOE51_RS05790	COG4999	Histidine kinase
DOE51_RS05805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DOE51_RS05815	COG1404	Belongs to the peptidase S8 family
DOE51_RS05840	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DOE51_RS05845	COG4968	Prepilin-type N-terminal cleavage methylation domain
DOE51_RS05855	COG0484	heat shock protein binding
DOE51_RS05860	COG0443	Heat shock 70 kDa protein
DOE51_RS05865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DOE51_RS05875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOE51_RS05890	COG1505	serine-type exopeptidase activity
DOE51_RS05915	COG1136	(ABC) transporter
DOE51_RS05915	COG0577	efflux transmembrane transporter activity
DOE51_RS05920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOE51_RS05930	COG3012	SEC-C Motif Domain Protein
DOE51_RS05935	COG4221	oxidoreductase activity
DOE51_RS06005	COG0271	Belongs to the BolA IbaG family
DOE51_RS06015	COG0488	(ABC) transporter
DOE51_RS06035	COG0024	Methionine aminopeptidase
DOE51_RS06040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DOE51_RS06055	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DOE51_RS06060	COG0745	RESPONSE REGULATOR receiver
DOE51_RS06105	COG4974	Belongs to the 'phage' integrase family
DOE51_RS06205	COG2204	response regulator
DOE51_RS06215	COG1192	Involved in chromosome partitioning
DOE51_RS06240	COG2755	lipolytic protein G-D-S-L family
DOE51_RS06240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DOE51_RS06390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DOE51_RS06395	COG0513	Belongs to the DEAD box helicase family
DOE51_RS06450	COG0488	(ABC) transporter
DOE51_RS06470	COG1201	RNA secondary structure unwinding
DOE51_RS06475	COG1793	dna ligase
DOE51_RS06500	COG1764	response to oxidative stress
DOE51_RS06520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOE51_RS06525	COG0604	alcohol dehydrogenase
DOE51_RS06545	COG0513	Belongs to the DEAD box helicase family
DOE51_RS06550	COG0488	(ABC) transporter
DOE51_RS06565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DOE51_RS06570	COG3842	ATPase activity
DOE51_RS06575	COG1176	ABC-type spermidine putrescine transport system, permease component I
DOE51_RS06580	COG1177	transmembrane transport
DOE51_RS06585	COG2270	Major facilitator Superfamily
DOE51_RS06595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DOE51_RS06605	COG1846	Transcriptional regulator
DOE51_RS06610	COG1418	mRNA catabolic process
DOE51_RS06625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DOE51_RS06630	COG1404	Belongs to the peptidase S8 family
DOE51_RS06650	COG2326	polyphosphate kinase activity
DOE51_RS06660	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DOE51_RS06665	COG1764	response to oxidative stress
DOE51_RS06670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DOE51_RS06685	COG1404	Belongs to the peptidase S8 family
DOE51_RS06730	COG3634	alkyl hydroperoxide reductase activity
DOE51_RS06745	COG0590	tRNA wobble adenosine to inosine editing
DOE51_RS06755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DOE51_RS06760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DOE51_RS06765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DOE51_RS06775	COG1466	dna polymerase III delta subunit
DOE51_RS06790	COG0728	peptidoglycan biosynthetic process
DOE51_RS06795	COG0840	transmembrane signaling receptor activity
DOE51_RS06800	COG0840	transmembrane signaling receptor activity
DOE51_RS06805	COG0840	transmembrane signaling receptor activity
DOE51_RS06855	COG0811	peptide transport
DOE51_RS06870	COG3956	TIGRFAM MazG family protein
DOE51_RS06880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DOE51_RS06890	COG1136	(ABC) transporter
DOE51_RS06890	COG0577	efflux transmembrane transporter activity
DOE51_RS06895	COG1136	(ABC) transporter
DOE51_RS06900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DOE51_RS06915	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOE51_RS06920	COG0673	inositol 2-dehydrogenase activity
DOE51_RS06930	COG1663	tetraacyldisaccharide 4'-kinase activity
DOE51_RS06935	COG1560	Kdo2-lipid A biosynthetic process
DOE51_RS06960	COG2204	response regulator
DOE51_RS06965	COG2205	protein histidine kinase activity
DOE51_RS06970	COG0196	riboflavin kinase activity
DOE51_RS06980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DOE51_RS06990	COG1459	type II secretion system
DOE51_RS06995	COG3852	Histidine kinase
DOE51_RS07000	COG2204	response regulator
DOE51_RS07070	COG0811	peptide transport
DOE51_RS07085	COG1490	D-aminoacyl-tRNA deacylase activity
DOE51_RS07090	COG0840	transmembrane signaling receptor activity
DOE51_RS07100	COG2205	protein histidine kinase activity
DOE51_RS07100	COG2198	Histidine kinase
DOE51_RS07100	COG0784	Response regulator, receiver
DOE51_RS07150	COG0564	pseudouridine synthase activity
DOE51_RS07170	COG0095	Lipoate-protein ligase
DOE51_RS07185	COG0488	(ABC) transporter
DOE51_RS07190	COG2824	Alkylphosphonate utilization operon protein PhnA
DOE51_RS07245	COG0779	Required for maturation of 30S ribosomal subunits
DOE51_RS07250	COG0195	Participates in both transcription termination and antitermination
DOE51_RS07255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DOE51_RS07260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DOE51_RS07265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DOE51_RS07270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DOE51_RS07275	COG1185	polyribonucleotide nucleotidyltransferase activity
DOE51_RS07280	COG0612	Peptidase, M16
DOE51_RS07285	COG0756	dUTP diphosphatase activity
DOE51_RS07310	COG0463	Glycosyl transferase, family 2
DOE51_RS07325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DOE51_RS07330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DOE51_RS07335	COG1561	YicC-like family, N-terminal region
DOE51_RS07340	COG0194	GDP metabolic process
DOE51_RS07345	COG1758	RNA polymerase activity
DOE51_RS07355	COG3852	Histidine kinase
DOE51_RS07370	COG0629	single-stranded DNA binding
DOE51_RS07415	COG1459	type II secretion system
DOE51_RS07420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DOE51_RS07425	COG1450	Type ii and iii secretion system protein
DOE51_RS07440	COG0840	transmembrane signaling receptor activity
DOE51_RS07445	COG3591	Belongs to the peptidase S1B family
DOE51_RS07455	COG2096	Adenosyltransferase
DOE51_RS07465	COG1333	cytochrome c biogenesis protein
DOE51_RS07470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DOE51_RS07470	COG1333	cytochrome c biogenesis protein
DOE51_RS07530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DOE51_RS07535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DOE51_RS07575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DOE51_RS07580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DOE51_RS07585	COG1304	FMN binding
DOE51_RS07630	COG0357	Ribosomal RNA small subunit methyltransferase G
DOE51_RS07630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOE51_RS07645	COG0357	Ribosomal RNA small subunit methyltransferase G
DOE51_RS07650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DOE51_RS07655	COG0072	phenylalanine-tRNA ligase activity
DOE51_RS07655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOE51_RS07660	COG0776	regulation of translation
DOE51_RS07695	COG0004	ammonium transporteR
DOE51_RS07720	COG0735	belongs to the Fur family
DOE51_RS07730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DOE51_RS07735	COG0573	inorganic phosphate transmembrane transporter activity
DOE51_RS07740	COG0581	inorganic phosphate transmembrane transporter activity
DOE51_RS07745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DOE51_RS07770	COG1215	transferase activity, transferring glycosyl groups
DOE51_RS07790	COG0463	Glycosyl transferase, family 2
DOE51_RS07825	COG0438	transferase activity, transferring glycosyl groups
DOE51_RS07855	COG0438	transferase activity, transferring glycosyl groups
DOE51_RS07860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DOE51_RS07880	COG0297	glycogen (starch) synthase activity
DOE51_RS07885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DOE51_RS07915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DOE51_RS07920	COG1410	methionine synthase
DOE51_RS07920	COG0646	methionine synthase
DOE51_RS07935	COG3021	interspecies interaction between organisms
DOE51_RS07965	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DOE51_RS07990	COG1720	tRNA m6t6A37 methyltransferase activity
DOE51_RS08000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOE51_RS08000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOE51_RS08015	COG1077	Cell shape determining protein MreB Mrl
DOE51_RS08045	COG1733	regulation of RNA biosynthetic process
DOE51_RS08050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DOE51_RS08055	COG4221	oxidoreductase activity
DOE51_RS08115	COG0583	DNA-binding transcription factor activity
DOE51_RS08120	COG2814	Major facilitator Superfamily
DOE51_RS08155	COG2267	carboxylic ester hydrolase activity
DOE51_RS08160	COG0739	heme binding
DOE51_RS08180	COG0745	RESPONSE REGULATOR receiver
DOE51_RS08195	COG2814	Major facilitator Superfamily
DOE51_RS08200	COG0840	transmembrane signaling receptor activity
DOE51_RS08285	COG0840	transmembrane signaling receptor activity
DOE51_RS08310	COG2076	Multidrug Resistance protein
DOE51_RS08320	COG0431	NADPH-dependent FMN reductase
DOE51_RS08325	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DOE51_RS08335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DOE51_RS08340	COG2205	protein histidine kinase activity
DOE51_RS08345	COG0745	RESPONSE REGULATOR receiver
DOE51_RS08375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOE51_RS08380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOE51_RS08395	COG2171	N-acyltransferase activity
DOE51_RS08405	COG0019	diaminopimelate decarboxylase activity
DOE51_RS08410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DOE51_RS08415	COG0517	IMP dehydrogenase activity
DOE51_RS08415	COG0516	GMP reductase activity
DOE51_RS08460	COG1247	-acetyltransferase
DOE51_RS08500	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DOE51_RS08520	COG0318	PFAM AMP-dependent synthetase and ligase
DOE51_RS08530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DOE51_RS08540	COG0326	Molecular chaperone. Has ATPase activity
DOE51_RS08550	COG3483	tryptophan 2,3-dioxygenase activity
DOE51_RS08610	COG0617	tRNA 3'-terminal CCA addition
DOE51_RS08635	COG2197	response regulator
DOE51_RS08640	COG1607	acyl-coa hydrolase
DOE51_RS08655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DOE51_RS08660	COG0281	malic enzyme
DOE51_RS08660	COG0280	phosphate acetyltransferase
DOE51_RS08685	COG0579	oxidoreductase
DOE51_RS08695	COG3104	oligopeptide transport
DOE51_RS08735	COG1250	3-hydroxyacyl-CoA dehydrogenase
DOE51_RS08740	COG1024	Enoyl-CoA hydratase
DOE51_RS08745	COG1703	isobutyryl-CoA mutase activity
DOE51_RS08745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOE51_RS08745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOE51_RS08760	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DOE51_RS08765	COG0688	phosphatidylethanolamine metabolic process
DOE51_RS08775	COG0720	synthase
DOE51_RS08815	COG1088	dTDP-glucose 4,6-dehydratase activity
DOE51_RS08820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DOE51_RS08825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DOE51_RS08830	COG0840	transmembrane signaling receptor activity
DOE51_RS08840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOE51_RS08845	COG1131	(ABC) transporter
DOE51_RS08850	COG1131	(ABC) transporter
DOE51_RS08855	COG1129	ABC transporter
DOE51_RS08855	COG0842	Transport permease protein
DOE51_RS08860	COG0842	Transport permease protein
DOE51_RS08875	COG0559	Belongs to the binding-protein-dependent transport system permease family
DOE51_RS08880	COG0411	ABC transporter
DOE51_RS08920	COG0386	Belongs to the glutathione peroxidase family
DOE51_RS08925	COG0740	serine-type endopeptidase activity
DOE51_RS08930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOE51_RS08945	COG0494	nUDIX hydrolase
DOE51_RS08950	COG1215	transferase activity, transferring glycosyl groups
DOE51_RS08980	COG2814	Major facilitator Superfamily
DOE51_RS08990	COG0724	RNA recognition motif
DOE51_RS09005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DOE51_RS09010	COG0824	Thioesterase
DOE51_RS09015	COG1494	fructose-1,6-bisphosphatase
DOE51_RS09025	COG4191	Histidine kinase
DOE51_RS09030	COG0745	RESPONSE REGULATOR receiver
DOE51_RS09050	COG1012	belongs to the aldehyde dehydrogenase family
DOE51_RS09055	COG0037	tRNA processing
DOE51_RS09060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DOE51_RS09065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DOE51_RS09075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOE51_RS09080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DOE51_RS09085	COG0802	atpase or kinase
DOE51_RS09090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE51_RS09105	COG0482	sulfurtransferase activity
DOE51_RS09110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOE51_RS09115	COG0571	ribonuclease III activity
DOE51_RS09125	COG1160	GTP binding
DOE51_RS09130	COG0733	neurotransmitter:sodium symporter activity
DOE51_RS09140	COG0386	Belongs to the glutathione peroxidase family
DOE51_RS09150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DOE51_RS09165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DOE51_RS09170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DOE51_RS09175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DOE51_RS09185	COG2814	Major facilitator Superfamily
DOE51_RS09215	COG2166	iron-sulfur cluster assembly
DOE51_RS09220	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
DOE51_RS09240	COG0583	DNA-binding transcription factor activity
DOE51_RS09265	COG0217	transcriptional regulatory protein
DOE51_RS09295	COG2900	Belongs to the SlyX family
DOE51_RS09300	COG1187	pseudouridine synthase activity
DOE51_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS09325	COG1716	ATPase activity
DOE51_RS09325	COG5001	Diguanylate cyclase
DOE51_RS09330	COG4166	transmembrane transport
DOE51_RS09335	COG1960	acyl-CoA dehydrogenase activity
DOE51_RS09340	COG1994	Peptidase M50
DOE51_RS09345	COG0180	Tryptophanyl-tRNA synthetase
DOE51_RS09350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DOE51_RS09355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DOE51_RS09390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOE51_RS09395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOE51_RS09395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DOE51_RS09400	COG1242	4 iron, 4 sulfur cluster binding
DOE51_RS09460	COG4942	peptidase
DOE51_RS09465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DOE51_RS09470	COG0698	ribose 5-phosphate isomerase
DOE51_RS09475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DOE51_RS09480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DOE51_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS09490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DOE51_RS09495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOE51_RS09500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DOE51_RS09510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DOE51_RS09515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE51_RS09520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DOE51_RS09520	COG1116	anion transmembrane transporter activity
DOE51_RS09545	COG0018	arginyl-trna synthetase
DOE51_RS09615	COG1011	Hydrolase
DOE51_RS09620	COG1837	Belongs to the UPF0109 family
DOE51_RS09640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOE51_RS09655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOE51_RS09690	COG0037	tRNA processing
DOE51_RS09695	COG0625	glutathione transferase activity
DOE51_RS09720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE51_RS09760	COG0519	Catalyzes the synthesis of GMP from XMP
DOE51_RS09760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DOE51_RS09765	COG0516	GMP reductase activity
DOE51_RS09765	COG0517	IMP dehydrogenase activity
DOE51_RS09770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DOE51_RS09775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DOE51_RS09780	COG0475	glutathione-regulated potassium exporter activity
DOE51_RS09790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOE51_RS09830	COG0183	Belongs to the thiolase family
DOE51_RS09835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DOE51_RS09840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DOE51_RS09885	COG0776	regulation of translation
DOE51_RS09920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DOE51_RS09930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DOE51_RS09935	COG0335	large ribosomal subunit rRNA binding
DOE51_RS09940	COG4752	Belongs to the RNA methyltransferase TrmD family
DOE51_RS09945	COG0336	Belongs to the RNA methyltransferase TrmD family
DOE51_RS09950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DOE51_RS09960	COG0228	four-way junction DNA binding
DOE51_RS09965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DOE51_RS09980	COG0842	Transport permease protein
DOE51_RS09985	COG1131	(ABC) transporter
DOE51_RS09990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DOE51_RS09995	COG1054	Belongs to the UPF0176 family
DOE51_RS10005	COG0668	transmembrane transport
DOE51_RS10010	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DOE51_RS10015	COG3387	PFAM Glycoside hydrolase 15-related
DOE51_RS10025	COG0582	viral genome integration into host DNA
DOE51_RS10250	COG3034	peptidoglycan biosynthetic process
DOE51_RS10370	COG1335	isochorismatase
DOE51_RS10380	COG3620	sequence-specific DNA binding
DOE51_RS10385	COG1335	isochorismatase
DOE51_RS10390	COG0826	peptidase U32
DOE51_RS10400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOE51_RS10415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOE51_RS10415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOE51_RS10425	COG0753	catalase activity
DOE51_RS10505	COG1051	belongs to the nudix hydrolase family
DOE51_RS10515	COG0328	RNA-DNA hybrid ribonuclease activity
DOE51_RS10525	COG0784	Response regulator, receiver
DOE51_RS10525	COG5002	protein histidine kinase activity
DOE51_RS10525	COG2198	Histidine kinase
DOE51_RS10540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DOE51_RS10545	COG0390	transport system, permease component
DOE51_RS10615	COG0443	Heat shock 70 kDa protein
DOE51_RS10625	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS10630	COG0628	permease
DOE51_RS10655	COG2197	response regulator
DOE51_RS10665	COG0038	chloride channel
DOE51_RS10670	COG2070	2-Nitropropane dioxygenase
DOE51_RS10685	COG0730	response to heat
DOE51_RS10695	COG2814	Major facilitator Superfamily
DOE51_RS10710	COG1418	mRNA catabolic process
DOE51_RS10715	COG0784	Response regulator, receiver
DOE51_RS10715	COG2205	protein histidine kinase activity
DOE51_RS10720	COG0656	L-ascorbic acid biosynthetic process
DOE51_RS10725	COG1253	flavin adenine dinucleotide binding
DOE51_RS10730	COG1960	acyl-CoA dehydrogenase activity
DOE51_RS10740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DOE51_RS10755	COG0726	polysaccharide deacetylase
DOE51_RS10780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOE51_RS10840	COG0484	heat shock protein binding
DOE51_RS10870	COG0616	signal peptide processing
DOE51_RS10875	COG0444	Belongs to the ABC transporter superfamily
DOE51_RS10880	COG4608	Belongs to the ABC transporter superfamily
DOE51_RS10890	COG0601	transmembrane transport
DOE51_RS10895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOE51_RS10905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOE51_RS10910	COG0584	glycerophosphoryl diester phosphodiesterase
DOE51_RS10920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOE51_RS10940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOE51_RS10945	COG1090	epimerase
DOE51_RS10950	COG0415	Belongs to the DNA photolyase family
DOE51_RS10955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DOE51_RS10960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOE51_RS10990	COG0109	protoheme IX farnesyltransferase activity
DOE51_RS10990	COG1612	heme a metabolic process
DOE51_RS11000	COG3011	Protein conserved in bacteria
DOE51_RS11005	COG0494	nUDIX hydrolase
DOE51_RS11025	COG2217	Heavy metal translocating P-type atpase
DOE51_RS11045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DOE51_RS11055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DOE51_RS11060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DOE51_RS11065	COG1862	Preprotein translocase
DOE51_RS11070	COG0343	queuine tRNA-ribosyltransferase activity
DOE51_RS11075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DOE51_RS11085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOE51_RS11105	COG1720	tRNA m6t6A37 methyltransferase activity
DOE51_RS11110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DOE51_RS11115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DOE51_RS11115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DOE51_RS11150	COG1012	belongs to the aldehyde dehydrogenase family
DOE51_RS11170	COG0572	uridine kinase
DOE51_RS11175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DOE51_RS11195	COG0783	Belongs to the Dps family
DOE51_RS11240	COG1741	Belongs to the pirin family
DOE51_RS11255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DOE51_RS11255	COG4651	solute:proton antiporter activity
DOE51_RS11260	COG1404	Belongs to the peptidase S8 family
DOE51_RS11265	COG1404	Belongs to the peptidase S8 family
DOE51_RS11270	COG0463	Glycosyl transferase, family 2
DOE51_RS11300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOE51_RS11320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DOE51_RS11385	COG0038	chloride channel
DOE51_RS11390	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DOE51_RS11410	COG0596	Alpha beta hydrolase
DOE51_RS11480	COG0281	malic enzyme
DOE51_RS11485	COG1733	regulation of RNA biosynthetic process
DOE51_RS11490	COG0625	glutathione transferase activity
DOE51_RS11500	COG0583	DNA-binding transcription factor activity
DOE51_RS11505	COG2814	Major facilitator Superfamily
DOE51_RS11510	COG2375	cellular response to nickel ion
DOE51_RS11515	COG1695	Transcriptional regulator
DOE51_RS11525	COG2226	methyltransferase
DOE51_RS11550	COG2226	methyltransferase
DOE51_RS11600	COG0288	reversible hydration of carbon dioxide
DOE51_RS11605	COG4974	Belongs to the 'phage' integrase family
DOE51_RS11630	COG2385	sporulation resulting in formation of a cellular spore
DOE51_RS11665	COG0728	peptidoglycan biosynthetic process
DOE51_RS11670	COG0322	excinuclease ABC activity
DOE51_RS11675	COG0556	nucleotide-excision repair
DOE51_RS11685	COG0215	cysteine-tRNA ligase activity
DOE51_RS11690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DOE51_RS11700	COG1404	Belongs to the peptidase S8 family
DOE51_RS11710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DOE51_RS11730	COG2340	Cysteine-rich secretory protein family
DOE51_RS11765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DOE51_RS11770	COG1830	Aldolase
DOE51_RS11775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DOE51_RS11775	COG0316	Belongs to the HesB IscA family
DOE51_RS11800	COG0477	Major facilitator Superfamily
DOE51_RS11805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DOE51_RS11810	COG0633	Ferredoxin
DOE51_RS11810	COG3217	Mosc domain protein beta barrel domain protein
DOE51_RS11845	COG4106	trans-aconitate 2-methyltransferase activity
DOE51_RS11850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DOE51_RS11855	COG0084	hydrolase, TatD family'
DOE51_RS11890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOE51_RS11890	COG0116	Belongs to the methyltransferase superfamily
DOE51_RS11910	COG0859	PFAM glycosyl transferase family 9
DOE51_RS11915	COG1519	Transferase
DOE51_RS11950	COG1234	tRNA 3'-trailer cleavage
DOE51_RS11960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOE51_RS11990	COG2770	Histidine kinase
DOE51_RS11990	COG2208	phosphoserine phosphatase activity
DOE51_RS12015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DOE51_RS12020	COG0717	Belongs to the dCTP deaminase family
DOE51_RS12055	COG3437	response regulator, receiver
DOE51_RS12055	COG0784	Response regulator, receiver
DOE51_RS12090	COG0543	2 iron, 2 sulfur cluster binding
DOE51_RS12090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DOE51_RS12110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DOE51_RS12125	COG1469	GTP cyclohydrolase I activity
DOE51_RS12130	COG0424	maF-like protein
DOE51_RS12135	COG0295	cytidine deaminase activity
DOE51_RS12170	COG1792	Involved in formation and maintenance of cell shape
DOE51_RS12180	COG0768	penicillin binding
DOE51_RS12185	COG0772	Belongs to the SEDS family
DOE51_RS12195	COG0604	alcohol dehydrogenase
DOE51_RS12200	COG0741	lytic transglycosylase activity
DOE51_RS12220	COG3118	belongs to the thioredoxin family
DOE51_RS12235	COG0758	DNA mediated transformation
DOE51_RS12265	COG0686	Belongs to the AlaDH PNT family
DOE51_RS12290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DOE51_RS12300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DOE51_RS12310	COG2255	four-way junction helicase activity
DOE51_RS12315	COG0632	four-way junction helicase activity
DOE51_RS12320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DOE51_RS12330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DOE51_RS12370	COG2079	MmgE PrpD family protein
DOE51_RS12375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DOE51_RS12390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOE51_RS12415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOE51_RS12440	COG2346	COG2346, Truncated hemoglobins
DOE51_RS12450	COG0308	aminopeptidase N
DOE51_RS12455	COG0302	gtp cyclohydrolase
DOE51_RS12525	COG1132	(ABC) transporter
DOE51_RS12530	COG1132	(ABC) transporter
DOE51_RS12535	COG2239	Acts as a magnesium transporter
DOE51_RS12595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DOE51_RS12605	COG2967	ApaG domain
DOE51_RS12630	COG0259	pyridoxamine-phosphate oxidase activity
DOE51_RS12635	COG0545	Peptidyl-prolyl cis-trans isomerase
DOE51_RS12640	COG2204	response regulator
DOE51_RS12665	COG0745	RESPONSE REGULATOR receiver
DOE51_RS12670	COG2205	protein histidine kinase activity
DOE51_RS12685	COG1132	(ABC) transporter
DOE51_RS12705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE51_RS12720	COG3278	Belongs to the heme-copper respiratory oxidase family
DOE51_RS12730	COG2010	Cytochrome c
DOE51_RS12735	COG0348	domain, Protein
DOE51_RS12745	COG2885	chlorophyll binding
DOE51_RS12755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DOE51_RS12765	COG0783	Belongs to the Dps family
DOE51_RS12775	COG0745	RESPONSE REGULATOR receiver
DOE51_RS12780	COG5002	protein histidine kinase activity
DOE51_RS12840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE51_RS12860	COG0076	glutamate decarboxylase activity
DOE51_RS12865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DOE51_RS12900	COG4335	DNA alkylation repair
DOE51_RS12905	COG0840	transmembrane signaling receptor activity
DOE51_RS12910	COG2346	COG2346, Truncated hemoglobins
DOE51_RS12945	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DOE51_RS12970	COG0840	transmembrane signaling receptor activity
DOE51_RS13005	COG3214	Protein conserved in bacteria
DOE51_RS13030	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DOE51_RS13030	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DOE51_RS13080	COG1752	Esterase of the alpha-beta hydrolase superfamily
DOE51_RS13085	COG3459	Glycosyltransferase 36 associated
DOE51_RS13095	COG0625	glutathione transferase activity
DOE51_RS13160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DOE51_RS13165	COG2917	probably involved in intracellular septation
DOE51_RS13170	COG2070	2-Nitropropane dioxygenase
DOE51_RS13175	COG1024	Enoyl-CoA hydratase
DOE51_RS13190	COG1968	undecaprenyl-diphosphatase activity
DOE51_RS13195	COG0668	transmembrane transport
DOE51_RS13230	COG0840	transmembrane signaling receptor activity
DOE51_RS13245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DOE51_RS13250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DOE51_RS13265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DOE51_RS13270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DOE51_RS13275	COG0193	aminoacyl-tRNA hydrolase activity
DOE51_RS13280	COG0012	GTP binding
DOE51_RS13290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOE51_RS13295	COG0601	transmembrane transport
DOE51_RS13305	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DOE51_RS13325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DOE51_RS13345	COG1228	amidohydrolase
DOE51_RS13350	COG0071	Belongs to the small heat shock protein (HSP20) family
DOE51_RS13375	COG0588	phosphoglycerate mutase activity
DOE51_RS13385	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOE51_RS13395	COG0583	DNA-binding transcription factor activity
DOE51_RS13405	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS13410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOE51_RS13420	COG2356	endonuclease I
DOE51_RS13470	COG1116	anion transmembrane transporter activity
DOE51_RS13475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE51_RS13485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DOE51_RS13515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DOE51_RS13520	COG0242	peptide deformylase activity
DOE51_RS13540	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DOE51_RS13540	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DOE51_RS13630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DOE51_RS13635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DOE51_RS13640	COG3631	Ketosteroid isomerase-related protein
DOE51_RS13650	COG1733	regulation of RNA biosynthetic process
DOE51_RS13695	COG2304	oxidoreductase activity
DOE51_RS13715	COG0714	Associated with various cellular activities
DOE51_RS13720	COG0501	Belongs to the peptidase M48B family
DOE51_RS13730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOE51_RS13735	COG2088	sporulation resulting in formation of a cellular spore
DOE51_RS13740	COG1858	cytochrome C peroxidase
DOE51_RS13765	COG1937	Protein conserved in bacteria
DOE51_RS13770	COG2132	Multicopper oxidase
DOE51_RS13800	COG0531	amino acid
DOE51_RS13805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DOE51_RS13820	COG1136	(ABC) transporter
DOE51_RS13845	COG2198	Histidine kinase
DOE51_RS13845	COG2205	protein histidine kinase activity
DOE51_RS13845	COG0784	Response regulator, receiver
DOE51_RS13885	COG0513	Belongs to the DEAD box helicase family
DOE51_RS13920	COG0459	protein refolding
DOE51_RS13990	COG0564	pseudouridine synthase activity
DOE51_RS14070	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DOE51_RS14080	COG1971	Probably functions as a manganese efflux pump
DOE51_RS14095	COG0583	DNA-binding transcription factor activity
DOE51_RS14115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOE51_RS14135	COG1741	Belongs to the pirin family
DOE51_RS14140	COG0583	DNA-binding transcription factor activity
DOE51_RS14155	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DOE51_RS14160	COG2204	response regulator
DOE51_RS14165	COG2198	Histidine kinase
DOE51_RS14165	COG0784	Response regulator, receiver
DOE51_RS14165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE51_RS14165	COG2205	protein histidine kinase activity
DOE51_RS14175	COG0583	DNA-binding transcription factor activity
DOE51_RS14185	COG3634	alkyl hydroperoxide reductase activity
DOE51_RS14200	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DOE51_RS14220	COG1061	Type III restriction enzyme res subunit
DOE51_RS14235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DOE51_RS14240	COG0667	Aldo Keto reductase
DOE51_RS14245	COG0366	Alpha amylase catalytic
DOE51_RS14250	COG2205	protein histidine kinase activity
DOE51_RS14250	COG0784	Response regulator, receiver
DOE51_RS14250	COG2198	Histidine kinase
DOE51_RS14250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE51_RS14325	COG0745	RESPONSE REGULATOR receiver
DOE51_RS14330	COG2205	protein histidine kinase activity
DOE51_RS14330	COG0784	Response regulator, receiver
DOE51_RS14380	COG1858	cytochrome C peroxidase
DOE51_RS14405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE51_RS14415	COG1902	pentaerythritol trinitrate reductase activity
DOE51_RS14435	COG1690	Belongs to the RtcB family
DOE51_RS14440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE51_RS14455	COG1027	Aspartate ammonia-lyase
DOE51_RS14520	COG1368	sulfuric ester hydrolase activity
DOE51_RS14530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DOE51_RS14540	COG0277	FAD linked oxidase domain protein
DOE51_RS14560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DOE51_RS14565	COG2204	response regulator
DOE51_RS14570	COG4589	Belongs to the CDS family
DOE51_RS14580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOE51_RS14590	COG1295	ribonuclease BN
DOE51_RS14605	COG1803	Methylglyoxal synthase
DOE51_RS14660	COG0840	transmembrane signaling receptor activity
DOE51_RS14690	COG2272	Belongs to the type-B carboxylesterase lipase family
DOE51_RS14740	COG1914	H( )-stimulated, divalent metal cation uptake system
DOE51_RS14745	COG2855	membrane
DOE51_RS14750	COG0583	DNA-binding transcription factor activity
DOE51_RS14770	COG1960	acyl-CoA dehydrogenase activity
DOE51_RS14800	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DOE51_RS14800	COG0662	Cupin 2, conserved barrel domain protein
DOE51_RS14810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DOE51_RS14830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOE51_RS14835	COG0203	ribosomal protein L17
DOE51_RS14840	COG0202	RNA polymerase activity
DOE51_RS14845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DOE51_RS14850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DOE51_RS14855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DOE51_RS14860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DOE51_RS14865	COG0563	adenylate kinase activity
DOE51_RS14870	COG0201	protein transport
DOE51_RS14875	COG0200	Binds to the 23S rRNA
DOE51_RS14880	COG1841	ribosomal large subunit assembly
DOE51_RS14885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DOE51_RS14890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DOE51_RS14895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DOE51_RS14900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DOE51_RS14905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DOE51_RS14910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DOE51_RS14915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DOE51_RS14920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DOE51_RS14925	COG0255	Belongs to the universal ribosomal protein uL29 family
DOE51_RS14930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DOE51_RS14935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DOE51_RS14940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DOE51_RS14945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DOE51_RS14950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DOE51_RS14955	COG0089	rRNA binding
DOE51_RS14960	COG0088	Forms part of the polypeptide exit tunnel
DOE51_RS14965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DOE51_RS14970	COG0051	transcription antitermination factor activity, RNA binding
DOE51_RS14975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DOE51_RS14980	COG0049	tRNA binding
DOE51_RS14985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DOE51_RS14990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DOE51_RS14995	COG0085	RNA polymerase activity
DOE51_RS15000	COG0222	ribosome binding
DOE51_RS15005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DOE51_RS15010	COG0081	regulation of translation
DOE51_RS15015	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DOE51_RS15035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DOE51_RS15055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOE51_RS15060	COG0284	orotidine-5'-phosphate decarboxylase activity
DOE51_RS15065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DOE51_RS15070	COG0138	bifunctional purine biosynthesis protein purh
DOE51_RS15075	COG0047	phosphoribosylformylglycinamidine synthase activity
DOE51_RS15080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DOE51_RS15085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DOE51_RS15090	COG0151	Belongs to the GarS family
DOE51_RS15100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DOE51_RS15120	COG0442	prolyl-tRNA aminoacylation
DOE51_RS15125	COG2204	response regulator
DOE51_RS15130	COG5000	phosphorelay sensor kinase activity
DOE51_RS15135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DOE51_RS15140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DOE51_RS15140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DOE51_RS15145	COG0307	riboflavin synthase, alpha
DOE51_RS15180	COG0542	response to heat
DOE51_RS15190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOE51_RS15215	COG2204	response regulator
DOE51_RS15230	COG1381	Involved in DNA repair and RecF pathway recombination
DOE51_RS15290	COG0583	DNA-binding transcription factor activity
DOE51_RS15310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOE51_RS15315	COG1034	ATP synthesis coupled electron transport
DOE51_RS15330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOE51_RS15330	COG0649	NAD binding
DOE51_RS15335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOE51_RS15375	COG1252	NADH dehydrogenase
DOE51_RS15405	COG1132	(ABC) transporter
DOE51_RS15410	COG1132	(ABC) transporter
DOE51_RS15435	COG3639	organic phosphonate transmembrane transporter activity
DOE51_RS15440	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DOE51_RS15460	COG1643	Atp-dependent helicase
DOE51_RS15470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DOE51_RS15485	COG1045	serine acetyltransferase
DOE51_RS15490	COG3481	metal-dependent phosphohydrolase, HD sub domain
DOE51_RS15505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DOE51_RS15510	COG1127	ABC transporter
DOE51_RS15515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOE51_RS15520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DOE51_RS15540	COG2267	carboxylic ester hydrolase activity
DOE51_RS15550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE51_RS15555	COG4221	oxidoreductase activity
DOE51_RS15560	COG0328	RNA-DNA hybrid ribonuclease activity
DOE51_RS15580	COG1074	ATP-dependent DNA helicase activity
DOE51_RS15620	COG0237	dephospho-CoA kinase activity
DOE51_RS15630	COG1022	Amp-dependent synthetase and ligase
DOE51_RS15650	COG0339	signal peptide processing
DOE51_RS15655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DOE51_RS15660	COG0497	DNA recombination
DOE51_RS15675	COG1271	oxidase subunit
DOE51_RS15685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DOE51_RS15690	COG0494	nUDIX hydrolase
DOE51_RS15700	COG2205	protein histidine kinase activity
DOE51_RS15725	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOE51_RS15730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DOE51_RS15745	COG0840	transmembrane signaling receptor activity
DOE51_RS15750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DOE51_RS15755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DOE51_RS15760	COG0772	Belongs to the SEDS family
DOE51_RS15770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DOE51_RS15775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DOE51_RS15785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DOE51_RS15790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DOE51_RS15805	COG0768	penicillin binding
DOE51_RS15815	COG0275	rRNA processing
DOE51_RS15825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DOE51_RS15845	COG1741	Belongs to the pirin family
DOE51_RS15855	COG0583	DNA-binding transcription factor activity
DOE51_RS15860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DOE51_RS15865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DOE51_RS15875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DOE51_RS15895	COG0739	heme binding
DOE51_RS15895	COG1196	nuclear chromosome segregation
DOE51_RS15895	COG0741	lytic transglycosylase activity
DOE51_RS15905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DOE51_RS15915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DOE51_RS15920	COG2176	DNA-directed DNA polymerase activity
DOE51_RS15930	COG1360	Flagellar Motor Protein
DOE51_RS15935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DOE51_RS15950	COG0840	transmembrane signaling receptor activity
DOE51_RS15980	COG1187	pseudouridine synthase activity
DOE51_RS16015	COG2264	protein methyltransferase activity
DOE51_RS16020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DOE51_RS16030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DOE51_RS16030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DOE51_RS16085	COG1858	cytochrome C peroxidase
DOE51_RS16090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DOE51_RS16125	COG1136	(ABC) transporter
DOE51_RS16135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOE51_RS16150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DOE51_RS16195	COG2204	response regulator
DOE51_RS16200	COG4964	Belongs to the GSP D family
DOE51_RS16225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DOE51_RS16235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DOE51_RS16250	COG0427	acetyl-CoA hydrolase
DOE51_RS16255	COG1191	sigma factor activity
DOE51_RS16265	COG1419	protein localization to endoplasmic reticulum
DOE51_RS16270	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOE51_RS16275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOE51_RS16280	COG1684	flagellar biosynthetic protein fliR
DOE51_RS16285	COG1987	bacterial-type flagellum assembly
DOE51_RS16290	COG1338	Plays a role in the flagellum-specific transport system
DOE51_RS16300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DOE51_RS16300	COG1776	CheC inhibitor of MCP methylation
DOE51_RS16320	COG0583	DNA-binding transcription factor activity
DOE51_RS16330	COG0300	oxidoreductase activity
DOE51_RS16340	COG4589	Belongs to the CDS family
DOE51_RS16350	COG0483	inositol monophosphate 1-phosphatase activity
DOE51_RS16370	COG0210	DNA helicase
DOE51_RS16430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DOE51_RS16435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE51_RS16445	COG0543	2 iron, 2 sulfur cluster binding
DOE51_RS16445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DOE51_RS16480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DOE51_RS16485	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DOE51_RS16500	COG0803	Belongs to the bacterial solute-binding protein 9 family
DOE51_RS16505	COG1121	(ABC) transporter
DOE51_RS16535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DOE51_RS16545	COG0205	6-phosphofructokinase activity
DOE51_RS16575	COG5002	protein histidine kinase activity
DOE51_RS16580	COG0745	RESPONSE REGULATOR receiver
DOE51_RS16615	COG1157	protein secretion by the type III secretion system
DOE51_RS16625	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DOE51_RS16630	COG1766	The M ring may be actively involved in energy transduction
DOE51_RS16635	COG1677	Flagellar hook-basal body complex protein FliE
DOE51_RS16645	COG1815	bacterial-type flagellum-dependent cell motility
DOE51_RS16650	COG2204	response regulator
DOE51_RS16665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOE51_RS16670	COG1127	ABC transporter
DOE51_RS16705	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DOE51_RS16715	COG1435	thymidine kinase activity
DOE51_RS16720	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DOE51_RS16730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DOE51_RS16735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DOE51_RS16755	COG2204	response regulator
DOE51_RS16800	COG0113	porphobilinogen synthase activity
DOE51_RS16805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DOE51_RS16815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DOE51_RS16825	COG0745	RESPONSE REGULATOR receiver
DOE51_RS16830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DOE51_RS16835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOE51_RS16845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DOE51_RS16850	COG1346	cytolysis
DOE51_RS16855	COG1380	Effector of murein hydrolase LrgA
DOE51_RS16875	COG2945	thiolester hydrolase activity
DOE51_RS16875	COG0596	Alpha beta hydrolase
DOE51_RS16880	COG0617	tRNA 3'-terminal CCA addition
DOE51_RS16890	COG2201	protein-glutamate methylesterase activity
DOE51_RS16895	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DOE51_RS16905	COG0835	chemotaxis
DOE51_RS16925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DOE51_RS16955	COG0596	Alpha beta hydrolase
DOE51_RS16960	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DOE51_RS16965	COG1169	isochorismate synthase
DOE51_RS16970	COG1605	Chorismate mutase
DOE51_RS16970	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DOE51_RS16975	COG2226	methyltransferase
DOE51_RS16995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DOE51_RS17000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DOE51_RS17005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DOE51_RS17010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DOE51_RS17025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DOE51_RS17035	COG0667	Aldo Keto reductase
DOE51_RS17040	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DOE51_RS17060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DOE51_RS17070	COG1956	GAF domain-containing protein
DOE51_RS17095	COG1309	transcriptional regulator
DOE51_RS17110	COG0708	Exodeoxyribonuclease III
DOE51_RS17160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE51_RS17200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DOE51_RS17230	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS17250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DOE51_RS17255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DOE51_RS17265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DOE51_RS17270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DOE51_RS17280	COG0488	(ABC) transporter
DOE51_RS17325	COG0439	Biotin carboxylase
DOE51_RS17330	COG0745	RESPONSE REGULATOR receiver
DOE51_RS17355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DOE51_RS17360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DOE51_RS17390	COG4555	ABC transporter
DOE51_RS17540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DOE51_RS17560	COG0517	IMP dehydrogenase activity
DOE51_RS17560	COG0516	GMP reductase activity
DOE51_RS17570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE51_RS17575	COG0514	ATP-dependent DNA helicase (RecQ)
DOE51_RS17580	COG0667	Aldo Keto reductase
DOE51_RS17605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOE51_RS17640	COG0861	Integral membrane protein TerC family
DOE51_RS17665	COG2995	paraquat-inducible protein a
DOE51_RS17670	COG3008	intermembrane lipid transfer
DOE51_RS17680	COG2814	Major facilitator Superfamily
DOE51_RS17690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DOE51_RS17710	COG0300	oxidoreductase activity
DOE51_RS17715	COG1309	transcriptional regulator
DOE51_RS17755	COG5002	protein histidine kinase activity
DOE51_RS17755	COG2205	protein histidine kinase activity
DOE51_RS17755	COG0784	Response regulator, receiver
DOE51_RS17760	COG2146	nitrite reductase [NAD(P)H] activity
DOE51_RS17760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DOE51_RS17775	COG0708	Exodeoxyribonuclease III
DOE51_RS17780	COG0702	epimerase
DOE51_RS17785	COG1733	regulation of RNA biosynthetic process
DOE51_RS17800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DOE51_RS17825	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DOE51_RS17830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DOE51_RS17835	COG2226	methyltransferase
DOE51_RS17840	COG1595	DNA-templated transcription, initiation
DOE51_RS17870	COG2897	thiosulfate sulfurtransferase activity
DOE51_RS17945	COG1028	Short-chain dehydrogenase reductase Sdr
DOE51_RS17950	COG1309	transcriptional regulator
DOE51_RS17955	COG0300	oxidoreductase activity
DOE51_RS18030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DOE51_RS18060	COG0538	isocitrate dehydrogenase activity
DOE51_RS18080	COG1752	Esterase of the alpha-beta hydrolase superfamily
DOE51_RS18090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DOE51_RS18095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DOE51_RS18100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DOE51_RS18105	COG1100	Small GTP-binding protein
DOE51_RS18110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DOE51_RS18180	COG3852	Histidine kinase
DOE51_RS18185	COG2204	response regulator
DOE51_RS18195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DOE51_RS18200	COG0740	serine-type endopeptidase activity
DOE51_RS18205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DOE51_RS18250	COG0003	Pfam Anion-transporting ATPase
DOE51_RS18260	COG0544	peptidyl-prolyl cis-trans isomerase activity
DOE51_RS18270	COG0596	Alpha beta hydrolase
DOE51_RS18280	COG0793	Belongs to the peptidase S41A family
DOE51_RS18290	COG2177	Part of the ABC transporter FtsEX involved in
DOE51_RS18295	COG2884	Cell division ATP-binding protein ftsE
DOE51_RS18310	COG1970	mechanosensitive ion channel activity
DOE51_RS18325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DOE51_RS18330	COG1132	(ABC) transporter
DOE51_RS18350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DOE51_RS18355	COG3876	Protein conserved in bacteria
DOE51_RS18380	COG1472	Belongs to the glycosyl hydrolase 3 family
DOE51_RS18390	COG0583	DNA-binding transcription factor activity
DOE51_RS18415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DOE51_RS18425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DOE51_RS18440	COG3850	Histidine kinase
DOE51_RS18440	COG4999	Histidine kinase
DOE51_RS18440	COG3437	response regulator, receiver
DOE51_RS18440	COG2205	protein histidine kinase activity
DOE51_RS18445	COG0052	Belongs to the universal ribosomal protein uS2 family
DOE51_RS18450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DOE51_RS18455	COG0528	UMP kinase activity
DOE51_RS18460	COG0233	cytoplasmic translational termination
DOE51_RS18465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DOE51_RS18475	COG0750	zinc metalloprotease
DOE51_RS18480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DOE51_RS18485	COG0489	protein tyrosine kinase activity
DOE51_RS18495	COG0564	pseudouridine synthase activity
DOE51_RS18500	COG1496	oxidoreductase activity
DOE51_RS18505	COG2094	Belongs to the DNA glycosylase MPG family
DOE51_RS18525	COG0626	cystathionine gamma-synthase activity
DOE51_RS18565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOE51_RS18575	COG1127	ABC transporter
DOE51_RS18580	COG1127	ABC transporter
DOE51_RS18585	COG0039	L-malate dehydrogenase activity
DOE51_RS18590	COG0045	succinate-CoA ligase (ADP-forming) activity
DOE51_RS18595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DOE51_RS18635	COG2942	2-epimerase
DOE51_RS18655	COG0105	UTP biosynthetic process
DOE51_RS18660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOE51_RS18670	COG1426	Protein conserved in bacteria
DOE51_RS18690	COG2176	DNA-directed DNA polymerase activity
DOE51_RS18695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DOE51_RS18695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DOE51_RS18715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOE51_RS18720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DOE51_RS18735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DOE51_RS18745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DOE51_RS18750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DOE51_RS18755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DOE51_RS18765	COG1530	ribonuclease E activity
DOE51_RS18785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DOE51_RS18805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DOE51_RS18810	COG0439	Biotin carboxylase
DOE51_RS18835	COG0805	protein transport
DOE51_RS18840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOE51_RS18860	COG0612	Peptidase, M16
DOE51_RS18865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOE51_RS18870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DOE51_RS18875	COG0484	heat shock protein binding
DOE51_RS18895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DOE51_RS18930	COG1007	ATP synthesis coupled electron transport
DOE51_RS18940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DOE51_RS18945	COG0713	ATP synthesis coupled electron transport
DOE51_RS18950	COG0839	Belongs to the complex I subunit 6 family
DOE51_RS18955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DOE51_RS18960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOE51_RS18975	COG1472	Belongs to the glycosyl hydrolase 3 family
DOE51_RS18980	COG0322	excinuclease ABC activity
DOE51_RS18985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DOE51_RS18985	COG1199	ATP-dependent helicase activity
DOE51_RS18995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DOE51_RS19000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DOE51_RS19005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DOE51_RS19010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DOE51_RS19015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOE51_RS19020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DOE51_RS19050	COG0357	Ribosomal RNA small subunit methyltransferase G
DOE51_RS19055	COG0445	tRNA wobble uridine modification
DOE51_RS19060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DOE51_RS19070	COG0706	membrane insertase activity
DOE51_RS19075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane