locus-tag	class	description
B9G69_RS00005	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B9G69_RS00025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B9G69_RS00065	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B9G69_RS00075	COG1131	(ABC) transporter
B9G69_RS00085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B9G69_RS00105	COG0681	Belongs to the peptidase S26 family
B9G69_RS00115	COG0681	Belongs to the peptidase S26 family
B9G69_RS00120	COG0681	Belongs to the peptidase S26 family
B9G69_RS00125	COG0481	GTPase activity
B9G69_RS00130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B9G69_RS00140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B9G69_RS00145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B9G69_RS00215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B9G69_RS00225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B9G69_RS00225	COG0517	IMP dehydrogenase activity
B9G69_RS00230	COG0504	CTP synthase activity
B9G69_RS00235	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B9G69_RS00240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B9G69_RS00245	COG2204	response regulator
B9G69_RS00260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B9G69_RS00260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B9G69_RS00285	COG0148	phosphopyruvate hydratase activity
B9G69_RS00315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B9G69_RS00315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9G69_RS00335	COG1489	DNA binding
B9G69_RS00355	COG0183	Belongs to the thiolase family
B9G69_RS00380	COG2030	dehydratase
B9G69_RS00385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B9G69_RS00400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9G69_RS00475	COG4580	involved in the transport of maltose and maltodextrins
B9G69_RS00485	COG1175	transmembrane transport
B9G69_RS00490	COG3833	ABC-type maltose transport systems, permease component
B9G69_RS00495	COG3842	ATPase activity
B9G69_RS00505	COG1940	carbohydrate kinase activity
B9G69_RS00520	COG0166	Belongs to the GPI family
B9G69_RS00535	COG1846	Transcriptional regulator
B9G69_RS00540	COG1764	response to oxidative stress
B9G69_RS00550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B9G69_RS00570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B9G69_RS00570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B9G69_RS00595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B9G69_RS00600	COG0167	dihydroorotate dehydrogenase activity
B9G69_RS00605	COG0494	nUDIX hydrolase
B9G69_RS00620	COG0776	regulation of translation
B9G69_RS00640	COG0312	modulator of DNA gyrase
B9G69_RS00670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B9G69_RS00670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B9G69_RS00675	COG0859	PFAM glycosyl transferase family 9
B9G69_RS00695	COG2264	protein methyltransferase activity
B9G69_RS00705	COG0509	glycine decarboxylation via glycine cleavage system
B9G69_RS00710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B9G69_RS00745	COG5002	protein histidine kinase activity
B9G69_RS00775	COG0784	Response regulator, receiver
B9G69_RS00775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G69_RS00775	COG2198	Histidine kinase
B9G69_RS00775	COG2205	protein histidine kinase activity
B9G69_RS00780	COG1490	D-aminoacyl-tRNA deacylase activity
B9G69_RS00825	COG3876	Protein conserved in bacteria
B9G69_RS00835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9G69_RS00885	COG0513	Belongs to the DEAD box helicase family
B9G69_RS00890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B9G69_RS00905	COG1272	protein, Hemolysin III
B9G69_RS00910	COG0494	nUDIX hydrolase
B9G69_RS00925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B9G69_RS00925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B9G69_RS00930	COG0024	Methionine aminopeptidase
B9G69_RS00950	COG2801	Transposase and inactivated derivatives
B9G69_RS00960	COG2814	Major facilitator Superfamily
B9G69_RS00975	COG1846	Transcriptional regulator
B9G69_RS00990	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B9G69_RS01010	COG0840	transmembrane signaling receptor activity
B9G69_RS01015	COG1388	LysM domain
B9G69_RS01025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B9G69_RS01030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B9G69_RS01035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B9G69_RS01050	COG2885	chlorophyll binding
B9G69_RS01110	COG2204	response regulator
B9G69_RS01115	COG1450	Type ii and iii secretion system protein
B9G69_RS01140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B9G69_RS01150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B9G69_RS01165	COG1191	sigma factor activity
B9G69_RS01175	COG1419	protein localization to endoplasmic reticulum
B9G69_RS01185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B9G69_RS01190	COG1684	flagellar biosynthetic protein fliR
B9G69_RS01195	COG1987	bacterial-type flagellum assembly
B9G69_RS01200	COG1338	Plays a role in the flagellum-specific transport system
B9G69_RS01240	COG4589	Belongs to the CDS family
B9G69_RS01245	COG0483	inositol monophosphate 1-phosphatase activity
B9G69_RS01275	COG0210	DNA helicase
B9G69_RS01290	COG1509	lysine 2,3-aminomutase activity
B9G69_RS01315	COG1136	(ABC) transporter
B9G69_RS01325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B9G69_RS01330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B9G69_RS01340	COG3956	TIGRFAM MazG family protein
B9G69_RS01355	COG0811	peptide transport
B9G69_RS01400	COG0840	transmembrane signaling receptor activity
B9G69_RS01415	COG0728	peptidoglycan biosynthetic process
B9G69_RS01420	COG0268	Binds directly to 16S ribosomal RNA
B9G69_RS01435	COG1466	dna polymerase III delta subunit
B9G69_RS01445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B9G69_RS01450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B9G69_RS01455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B9G69_RS01490	COG0596	Alpha beta hydrolase
B9G69_RS01505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B9G69_RS01515	COG0784	Response regulator, receiver
B9G69_RS01515	COG2205	protein histidine kinase activity
B9G69_RS01520	COG5002	protein histidine kinase activity
B9G69_RS01525	COG0784	Response regulator, receiver
B9G69_RS01530	COG4191	Histidine kinase
B9G69_RS01545	COG0784	Response regulator, receiver
B9G69_RS01545	COG2205	protein histidine kinase activity
B9G69_RS01545	COG2198	Histidine kinase
B9G69_RS01555	COG1764	response to oxidative stress
B9G69_RS01560	COG2326	polyphosphate kinase activity
B9G69_RS01575	COG1956	GAF domain-containing protein
B9G69_RS01580	COG1404	Belongs to the peptidase S8 family
B9G69_RS01600	COG1418	mRNA catabolic process
B9G69_RS01605	COG0564	pseudouridine synthase activity
B9G69_RS01610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B9G69_RS01620	COG2270	Major facilitator Superfamily
B9G69_RS01635	COG0488	(ABC) transporter
B9G69_RS01695	COG0095	Lipoate-protein ligase
B9G69_RS01700	COG0513	Belongs to the DEAD box helicase family
B9G69_RS01710	COG2015	COG2015, Alkyl sulfatase and related hydrolases
B9G69_RS01745	COG0281	malic enzyme
B9G69_RS01810	COG1309	transcriptional regulator
B9G69_RS01835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9G69_RS01875	COG0840	transmembrane signaling receptor activity
B9G69_RS01910	COG0826	peptidase U32
B9G69_RS01920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B9G69_RS01945	COG2195	Cleaves the N-terminal amino acid of tripeptides
B9G69_RS01955	COG0039	L-malate dehydrogenase activity
B9G69_RS01985	COG2226	methyltransferase
B9G69_RS02010	COG0745	RESPONSE REGULATOR receiver
B9G69_RS02015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B9G69_RS02030	COG3237	CsbD-like
B9G69_RS02060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B9G69_RS02065	COG0024	Methionine aminopeptidase
B9G69_RS02085	COG0488	(ABC) transporter
B9G69_RS02155	COG4221	oxidoreductase activity
B9G69_RS02160	COG3012	SEC-C Motif Domain Protein
B9G69_RS02180	COG1136	(ABC) transporter
B9G69_RS02180	COG0577	efflux transmembrane transporter activity
B9G69_RS02205	COG0730	response to heat
B9G69_RS02245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B9G69_RS02265	COG0513	Belongs to the DEAD box helicase family
B9G69_RS02270	COG0443	Heat shock 70 kDa protein
B9G69_RS02315	COG0519	Catalyzes the synthesis of GMP from XMP
B9G69_RS02320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9G69_RS02355	COG0745	RESPONSE REGULATOR receiver
B9G69_RS02365	COG4251	negative regulation of phosphorylation
B9G69_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS02405	COG3437	response regulator, receiver
B9G69_RS02405	COG2205	protein histidine kinase activity
B9G69_RS02405	COG4999	Histidine kinase
B9G69_RS02405	COG3850	Histidine kinase
B9G69_RS02415	COG1215	transferase activity, transferring glycosyl groups
B9G69_RS02430	COG0745	RESPONSE REGULATOR receiver
B9G69_RS02475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B9G69_RS02515	COG0514	ATP-dependent DNA helicase (RecQ)
B9G69_RS02535	COG5002	protein histidine kinase activity
B9G69_RS02535	COG0784	Response regulator, receiver
B9G69_RS02535	COG2205	protein histidine kinase activity
B9G69_RS02595	COG2259	Doxx family
B9G69_RS02615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B9G69_RS02620	COG2917	probably involved in intracellular septation
B9G69_RS02635	COG1024	Enoyl-CoA hydratase
B9G69_RS02650	COG1968	undecaprenyl-diphosphatase activity
B9G69_RS02655	COG0668	transmembrane transport
B9G69_RS02660	COG0740	serine-type endopeptidase activity
B9G69_RS02680	COG0860	N-Acetylmuramoyl-L-alanine amidase
B9G69_RS02685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B9G69_RS02690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B9G69_RS02700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B9G69_RS02705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B9G69_RS02710	COG0193	aminoacyl-tRNA hydrolase activity
B9G69_RS02715	COG0012	GTP binding
B9G69_RS02730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9G69_RS02735	COG0601	transmembrane transport
B9G69_RS02745	COG0259	pyridoxamine-phosphate oxidase activity
B9G69_RS02750	COG0545	Peptidyl-prolyl cis-trans isomerase
B9G69_RS02765	COG0745	RESPONSE REGULATOR receiver
B9G69_RS02770	COG2205	protein histidine kinase activity
B9G69_RS02805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B9G69_RS02810	COG2885	chlorophyll binding
B9G69_RS02820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B9G69_RS02830	COG0783	Belongs to the Dps family
B9G69_RS02845	COG0745	RESPONSE REGULATOR receiver
B9G69_RS02850	COG3850	Histidine kinase
B9G69_RS02850	COG5002	protein histidine kinase activity
B9G69_RS02910	COG1012	belongs to the aldehyde dehydrogenase family
B9G69_RS02930	COG0572	uridine kinase
B9G69_RS02935	COG0531	amino acid
B9G69_RS02940	COG2346	COG2346, Truncated hemoglobins
B9G69_RS02950	COG2824	Alkylphosphonate utilization operon protein PhnA
B9G69_RS02980	COG0484	heat shock protein binding
B9G69_RS03000	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B9G69_RS03005	COG0542	response to heat
B9G69_RS03050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B9G69_RS03130	COG0473	3-isopropylmalate dehydrogenase activity
B9G69_RS03145	COG2205	protein histidine kinase activity
B9G69_RS03150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B9G69_RS03160	COG0179	Fumarylacetoacetate (FAA) hydrolase
B9G69_RS03165	COG1012	belongs to the aldehyde dehydrogenase family
B9G69_RS03175	COG0724	RNA recognition motif
B9G69_RS03245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9G69_RS03265	COG5640	endopeptidase activity
B9G69_RS03280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B9G69_RS03285	COG1741	Belongs to the pirin family
B9G69_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS03340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B9G69_RS03345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B9G69_RS03355	COG0726	polysaccharide deacetylase
B9G69_RS03370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B9G69_RS03375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B9G69_RS03400	COG2986	histidine ammonia-lyase
B9G69_RS03410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B9G69_RS03415	COG1704	LemA family
B9G69_RS03420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B9G69_RS03420	COG0116	Belongs to the methyltransferase superfamily
B9G69_RS03435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B9G69_RS03440	COG1640	4-alpha-glucanotransferase
B9G69_RS03445	COG0366	Alpha amylase catalytic
B9G69_RS03450	COG0366	Alpha amylase catalytic
B9G69_RS03470	COG0668	transmembrane transport
B9G69_RS03480	COG5599	Phosphatase
B9G69_RS03490	COG1960	acyl-CoA dehydrogenase activity
B9G69_RS03495	COG1058	Belongs to the CinA family
B9G69_RS03495	COG1546	Belongs to the CinA family
B9G69_RS03505	COG2814	Major facilitator Superfamily
B9G69_RS03510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B9G69_RS03510	COG0539	negative regulation of cytoplasmic translation
B9G69_RS03515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B9G69_RS03525	COG1104	cysteine desulfurase activity
B9G69_RS03530	COG0316	Belongs to the HesB IscA family
B9G69_RS03545	COG0596	Alpha beta hydrolase
B9G69_RS03555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B9G69_RS03560	COG1418	mRNA catabolic process
B9G69_RS03565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B9G69_RS03570	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B9G69_RS03580	COG2989	Protein conserved in bacteria
B9G69_RS03605	COG0552	protein localization to endoplasmic reticulum
B9G69_RS03635	COG1959	2 iron, 2 sulfur cluster binding
B9G69_RS03665	COG0583	DNA-binding transcription factor activity
B9G69_RS03675	COG1196	nuclear chromosome segregation
B9G69_RS03700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9G69_RS03700	COG0574	Belongs to the PEP-utilizing enzyme family
B9G69_RS03720	COG0423	glycine-tRNA ligase activity
B9G69_RS03740	COG0489	protein tyrosine kinase activity
B9G69_RS03770	COG0791	NLP P60 protein
B9G69_RS03770	COG1388	LysM domain
B9G69_RS03820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B9G69_RS03830	COG4181	ATPase activity
B9G69_RS03845	COG0124	histidyl-tRNA synthetase
B9G69_RS03865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B9G69_RS03890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B9G69_RS03890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B9G69_RS03900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B9G69_RS03905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B9G69_RS03920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B9G69_RS03925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B9G69_RS03935	COG0840	transmembrane signaling receptor activity
B9G69_RS03940	COG0583	DNA-binding transcription factor activity
B9G69_RS03955	COG0612	Peptidase, M16
B9G69_RS03990	COG0616	signal peptide processing
B9G69_RS04025	COG1573	uracil-dna glycosylase
B9G69_RS04030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B9G69_RS04035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B9G69_RS04050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9G69_RS04065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B9G69_RS04080	COG0149	triose-phosphate isomerase activity
B9G69_RS04085	COG0126	phosphoglycerate kinase activity
B9G69_RS04090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B9G69_RS04100	COG1272	protein, Hemolysin III
B9G69_RS04115	COG0084	hydrolase, TatD family'
B9G69_RS04120	COG0470	DNA polymerase III
B9G69_RS04125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B9G69_RS04180	COG0598	Magnesium transport protein CorA
B9G69_RS04190	COG4106	trans-aconitate 2-methyltransferase activity
B9G69_RS04255	COG2850	peptidyl-arginine hydroxylation
B9G69_RS04260	COG5002	protein histidine kinase activity
B9G69_RS04270	COG0704	Plays a role in the regulation of phosphate uptake
B9G69_RS04280	COG0248	Ppx GppA phosphatase
B9G69_RS04290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B9G69_RS04295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B9G69_RS04315	COG3384	dioxygenase
B9G69_RS04350	COG0488	(ABC) transporter
B9G69_RS04355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B9G69_RS04365	COG0514	ATP-dependent DNA helicase (RecQ)
B9G69_RS04370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B9G69_RS04415	COG1253	flavin adenine dinucleotide binding
B9G69_RS04420	COG1324	tolerance protein
B9G69_RS04425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B9G69_RS04470	COG3794	PFAM blue (type 1) copper domain protein
B9G69_RS04490	COG0793	Belongs to the peptidase S41A family
B9G69_RS04505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B9G69_RS04505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9G69_RS04510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B9G69_RS04525	COG0312	modulator of DNA gyrase
B9G69_RS04530	COG0312	modulator of DNA gyrase
B9G69_RS04550	COG0693	protein deglycase activity
B9G69_RS04570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B9G69_RS04580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9G69_RS04590	COG4999	Histidine kinase
B9G69_RS04590	COG3850	Histidine kinase
B9G69_RS04590	COG3437	response regulator, receiver
B9G69_RS04590	COG2205	protein histidine kinase activity
B9G69_RS04605	COG0116	Belongs to the methyltransferase superfamily
B9G69_RS04610	COG0644	oxidoreductase
B9G69_RS04610	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B9G69_RS04630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B9G69_RS04635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B9G69_RS04640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B9G69_RS04840	COG0798	PFAM Bile acid sodium symporter
B9G69_RS04845	COG0431	NADPH-dependent FMN reductase
B9G69_RS04850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B9G69_RS04855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B9G69_RS04885	COG3214	Protein conserved in bacteria
B9G69_RS04910	COG1404	Belongs to the peptidase S8 family
B9G69_RS04970	COG0784	Response regulator, receiver
B9G69_RS04970	COG2205	protein histidine kinase activity
B9G69_RS04970	COG5002	protein histidine kinase activity
B9G69_RS04975	COG0840	transmembrane signaling receptor activity
B9G69_RS05000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9G69_RS05000	COG0723	plastoquinol--plastocyanin reductase activity
B9G69_RS05020	COG2154	pterin-4-alpha-carbinolamine dehydratase
B9G69_RS05030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B9G69_RS05045	COG2353	YceI-like domain
B9G69_RS05055	COG2885	chlorophyll binding
B9G69_RS05105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9G69_RS05110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B9G69_RS05125	COG0840	transmembrane signaling receptor activity
B9G69_RS05130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B9G69_RS05135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B9G69_RS05140	COG0772	Belongs to the SEDS family
B9G69_RS05150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B9G69_RS05155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B9G69_RS05175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B9G69_RS05180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B9G69_RS05215	COG0768	penicillin binding
B9G69_RS05225	COG0275	rRNA processing
B9G69_RS05235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B9G69_RS05250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B9G69_RS05255	COG0724	RNA recognition motif
B9G69_RS05280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B9G69_RS05295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B9G69_RS05315	COG0741	lytic transglycosylase activity
B9G69_RS05315	COG1196	nuclear chromosome segregation
B9G69_RS05315	COG0739	heme binding
B9G69_RS05325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B9G69_RS05330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B9G69_RS05345	COG1360	Flagellar Motor Protein
B9G69_RS05350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B9G69_RS05385	COG1187	pseudouridine synthase activity
B9G69_RS05405	COG2264	protein methyltransferase activity
B9G69_RS05410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B9G69_RS05420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B9G69_RS05420	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B9G69_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS05490	COG0745	RESPONSE REGULATOR receiver
B9G69_RS05510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B9G69_RS05525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B9G69_RS05545	COG5640	endopeptidase activity
B9G69_RS05580	COG0436	Aminotransferase
B9G69_RS05585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B9G69_RS05590	COG0742	ribosomal rna small subunit methyltransferase
B9G69_RS05595	COG0745	RESPONSE REGULATOR receiver
B9G69_RS05600	COG3852	Histidine kinase
B9G69_RS05610	COG0859	PFAM glycosyl transferase family 9
B9G69_RS05635	COG1516	flagellar protein fliS
B9G69_RS05640	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B9G69_RS05650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B9G69_RS05660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B9G69_RS05670	COG0784	Response regulator, receiver
B9G69_RS05670	COG2205	protein histidine kinase activity
B9G69_RS05675	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B9G69_RS05695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B9G69_RS05715	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B9G69_RS05720	COG1181	Belongs to the D-alanine--D-alanine ligase family
B9G69_RS05735	COG2201	protein-glutamate methylesterase activity
B9G69_RS05745	COG0643	Histidine kinase
B9G69_RS05745	COG2198	Histidine kinase
B9G69_RS05775	COG0537	adenosine 5'-monophosphoramidase activity
B9G69_RS05790	COG0372	Belongs to the citrate synthase family
B9G69_RS05830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B9G69_RS05840	COG0142	geranyltranstransferase activity
B9G69_RS05845	COG0824	Thioesterase
B9G69_RS05865	COG0318	PFAM AMP-dependent synthetase and ligase
B9G69_RS05875	COG1575	Belongs to the MenA family. Type 1 subfamily
B9G69_RS05890	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B9G69_RS05925	COG1706	bacterial-type flagellum-dependent cell motility
B9G69_RS05965	COG0386	Belongs to the glutathione peroxidase family
B9G69_RS06000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B9G69_RS06005	COG1546	Belongs to the CinA family
B9G69_RS06005	COG1058	Belongs to the CinA family
B9G69_RS06010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B9G69_RS06020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B9G69_RS06025	COG1408	metallophosphoesterase
B9G69_RS06035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B9G69_RS06060	COG0840	transmembrane signaling receptor activity
B9G69_RS06065	COG1505	serine-type exopeptidase activity
B9G69_RS06075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B9G69_RS06080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B9G69_RS06085	COG0101	tRNA pseudouridine synthase activity
B9G69_RS06100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B9G69_RS06105	COG1183	phosphatidylcholine synthase activity
B9G69_RS06150	COG1716	ATPase activity
B9G69_RS06175	COG0424	maF-like protein
B9G69_RS06190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B9G69_RS06205	COG1872	DUF167
B9G69_RS06230	COG0525	valine-tRNA ligase activity
B9G69_RS06250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B9G69_RS06255	COG1744	ABC transporter substrate-binding protein PnrA-like
B9G69_RS06260	COG3845	ABC transporter
B9G69_RS06265	COG4603	Belongs to the binding-protein-dependent transport system permease family
B9G69_RS06270	COG1079	Belongs to the binding-protein-dependent transport system permease family
B9G69_RS06280	COG0583	DNA-binding transcription factor activity
B9G69_RS06285	COG0753	catalase activity
B9G69_RS06295	COG0840	transmembrane signaling receptor activity
B9G69_RS06315	COG0557	exoribonuclease II activity
B9G69_RS06320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B9G69_RS06325	COG0583	DNA-binding transcription factor activity
B9G69_RS06340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B9G69_RS06345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B9G69_RS06370	COG0183	Belongs to the thiolase family
B9G69_RS06390	COG0739	heme binding
B9G69_RS06395	COG0631	protein serine/threonine phosphatase activity
B9G69_RS06425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B9G69_RS06470	COG0587	DNA-directed DNA polymerase activity
B9G69_RS06525	COG0492	ferredoxin-NADP+ reductase activity
B9G69_RS06535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B9G69_RS06540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B9G69_RS06550	COG0495	leucyl-tRNA aminoacylation
B9G69_RS06555	COG1166	arginine decarboxylase activity
B9G69_RS06570	COG4239	(ABC) transporter, permease
B9G69_RS06575	COG4174	ABC transporter (Permease)
B9G69_RS06580	COG4166	transmembrane transport
B9G69_RS06585	COG0010	Belongs to the arginase family
B9G69_RS06590	COG1393	Belongs to the ArsC family
B9G69_RS06595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B9G69_RS06610	COG0009	L-threonylcarbamoyladenylate synthase
B9G69_RS06620	COG4181	ATPase activity
B9G69_RS06630	COG0724	RNA recognition motif
B9G69_RS06635	COG1666	GTP binding
B9G69_RS06640	COG1047	Peptidyl-prolyl cis-trans
B9G69_RS06655	COG2223	nitrite transmembrane transporter activity
B9G69_RS06675	COG0656	L-ascorbic acid biosynthetic process
B9G69_RS06680	COG2855	membrane
B9G69_RS06690	COG0513	Belongs to the DEAD box helicase family
B9G69_RS06720	COG1492	cobalamin metabolic process
B9G69_RS06800	COG0582	viral genome integration into host DNA
B9G69_RS06815	COG2207	Transcriptional regulator
B9G69_RS06820	COG0667	Aldo Keto reductase
B9G69_RS06870	COG1061	Type III restriction enzyme res subunit
B9G69_RS06875	COG0513	Belongs to the DEAD box helicase family
B9G69_RS06890	COG0357	Ribosomal RNA small subunit methyltransferase G
B9G69_RS06905	COG4221	oxidoreductase activity
B9G69_RS06905	COG0604	alcohol dehydrogenase
B9G69_RS06905	COG3321	synthase
B9G69_RS06905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B9G69_RS06915	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B9G69_RS06955	COG2032	superoxide dismutase activity
B9G69_RS06975	COG0625	glutathione transferase activity
B9G69_RS06985	COG0109	protoheme IX farnesyltransferase activity
B9G69_RS07000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B9G69_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS07050	COG0653	protein targeting
B9G69_RS07055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B9G69_RS07065	COG0347	Belongs to the P(II) protein family
B9G69_RS07075	COG0509	glycine decarboxylation via glycine cleavage system
B9G69_RS07090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B9G69_RS07095	COG1064	alcohol dehydrogenase
B9G69_RS07155	COG0358	DNA primase activity
B9G69_RS07160	COG1610	YqeY-like protein
B9G69_RS07165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B9G69_RS07195	COG0745	RESPONSE REGULATOR receiver
B9G69_RS07205	COG2719	SpoVR family
B9G69_RS07210	COG2718	Belongs to the UPF0229 family
B9G69_RS07215	COG2766	serine protein kinase
B9G69_RS07240	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B9G69_RS07255	COG2003	Belongs to the UPF0758 family
B9G69_RS07290	COG5002	protein histidine kinase activity
B9G69_RS07305	COG1077	Cell shape determining protein MreB Mrl
B9G69_RS07310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B9G69_RS07325	COG1671	Belongs to the UPF0178 family
B9G69_RS07330	COG0006	proline dipeptidase activity
B9G69_RS07340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B9G69_RS07350	COG1722	exodeoxyribonuclease VII activity
B9G69_RS07380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B9G69_RS07385	COG0719	Fe-S assembly protein
B9G69_RS07390	COG0396	ATPase activity
B9G69_RS07395	COG0719	Fe-S assembly protein
B9G69_RS07425	COG0823	Involved in the tonB-independent uptake of proteins
B9G69_RS07430	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B9G69_RS07445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B9G69_RS07470	COG1360	Flagellar Motor Protein
B9G69_RS07475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B9G69_RS07480	COG0671	phosphoesterase, PA-phosphatase related
B9G69_RS07485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9G69_RS07490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9G69_RS07505	COG1217	gtp-binding protein TYPA
B9G69_RS07510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B9G69_RS07520	COG0527	aspartate kinase activity
B9G69_RS07530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B9G69_RS07535	COG1012	belongs to the aldehyde dehydrogenase family
B9G69_RS07550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B9G69_RS07560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9G69_RS07570	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B9G69_RS07575	COG0840	transmembrane signaling receptor activity
B9G69_RS07655	COG2201	protein-glutamate methylesterase activity
B9G69_RS07670	COG0459	protein refolding
B9G69_RS07675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B9G69_RS07730	COG0519	Catalyzes the synthesis of GMP from XMP
B9G69_RS07760	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B9G69_RS07765	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B9G69_RS07780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B9G69_RS07785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B9G69_RS07810	COG0586	Pfam SNARE associated Golgi protein
B9G69_RS07825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B9G69_RS07845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B9G69_RS07850	COG2890	protein-(glutamine-N5) methyltransferase activity
B9G69_RS07855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B9G69_RS07860	COG0254	rRNA binding
B9G69_RS07875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B9G69_RS07895	COG0248	Ppx GppA phosphatase
B9G69_RS07895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B9G69_RS07900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B9G69_RS07905	COG0154	amidase activity
B9G69_RS07920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B9G69_RS07950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B9G69_RS07960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B9G69_RS07965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B9G69_RS07970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B9G69_RS07990	COG1674	ftsk spoiiie
B9G69_RS07995	COG0602	queuosine metabolic process
B9G69_RS08005	COG0305	Participates in initiation and elongation during chromosome replication
B9G69_RS08010	COG0300	oxidoreductase activity
B9G69_RS08030	COG0359	binds to the 23S rRNA
B9G69_RS08040	COG0360	Binds together with S18 to 16S ribosomal RNA
B9G69_RS08060	COG1404	Belongs to the peptidase S8 family
B9G69_RS08080	COG1053	succinate dehydrogenase
B9G69_RS08090	COG2086	electron transfer activity
B9G69_RS08095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B9G69_RS08105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B9G69_RS08115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B9G69_RS08120	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B9G69_RS08130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B9G69_RS08135	COG0356	it plays a direct role in the translocation of protons across the membrane
B9G69_RS08160	COG0187	DNA topoisomerase II activity
B9G69_RS08165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B9G69_RS08175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B9G69_RS08185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B9G69_RS08190	COG0706	membrane insertase activity
B9G69_RS08200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B9G69_RS08205	COG0445	tRNA wobble uridine modification
B9G69_RS08210	COG0357	Ribosomal RNA small subunit methyltransferase G
B9G69_RS08220	COG1192	Involved in chromosome partitioning
B9G69_RS08240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B9G69_RS08245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B9G69_RS08250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B9G69_RS08255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B9G69_RS08260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B9G69_RS08265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B9G69_RS08275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B9G69_RS08275	COG1199	ATP-dependent helicase activity
B9G69_RS08280	COG0322	excinuclease ABC activity
B9G69_RS08285	COG1472	Belongs to the glycosyl hydrolase 3 family
B9G69_RS08300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9G69_RS08305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B9G69_RS08315	COG0713	ATP synthesis coupled electron transport
B9G69_RS08330	COG1007	ATP synthesis coupled electron transport
B9G69_RS08355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B9G69_RS08365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B9G69_RS08375	COG0484	heat shock protein binding
B9G69_RS08380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B9G69_RS08385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B9G69_RS08390	COG0612	Peptidase, M16
B9G69_RS08415	COG0805	protein transport
B9G69_RS08425	COG0439	Biotin carboxylase
B9G69_RS08430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B9G69_RS08435	COG1404	Belongs to the peptidase S8 family
B9G69_RS08455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B9G69_RS08465	COG1530	ribonuclease E activity
B9G69_RS08475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B9G69_RS08480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B9G69_RS08485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B9G69_RS08490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B9G69_RS08495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B9G69_RS08510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9G69_RS08530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B9G69_RS08530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9G69_RS08535	COG2176	DNA-directed DNA polymerase activity
B9G69_RS08540	COG0633	Ferredoxin
B9G69_RS08550	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B9G69_RS08555	COG1426	Protein conserved in bacteria
B9G69_RS08565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B9G69_RS08570	COG0105	UTP biosynthetic process
B9G69_RS08580	COG2942	2-epimerase
B9G69_RS08585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9G69_RS08615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B9G69_RS08620	COG0045	succinate-CoA ligase (ADP-forming) activity
B9G69_RS08625	COG1127	ABC transporter
B9G69_RS08630	COG1127	ABC transporter
B9G69_RS08635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B9G69_RS08640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B9G69_RS08675	COG0626	cystathionine gamma-synthase activity
B9G69_RS08685	COG0783	Belongs to the Dps family
B9G69_RS08690	COG2094	Belongs to the DNA glycosylase MPG family
B9G69_RS08695	COG1496	oxidoreductase activity
B9G69_RS08700	COG0564	pseudouridine synthase activity
B9G69_RS08715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B9G69_RS08720	COG0750	zinc metalloprotease
B9G69_RS08725	COG4589	Belongs to the CDS family
B9G69_RS08730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B9G69_RS08735	COG0233	cytoplasmic translational termination
B9G69_RS08740	COG0528	UMP kinase activity
B9G69_RS08745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B9G69_RS08750	COG0052	Belongs to the universal ribosomal protein uS2 family
B9G69_RS08765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B9G69_RS08775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B9G69_RS08805	COG1472	Belongs to the glycosyl hydrolase 3 family
B9G69_RS08830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B9G69_RS08855	COG1132	(ABC) transporter
B9G69_RS08875	COG1970	mechanosensitive ion channel activity
B9G69_RS08890	COG2884	Cell division ATP-binding protein ftsE
B9G69_RS08905	COG0793	Belongs to the peptidase S41A family
B9G69_RS08915	COG0596	Alpha beta hydrolase
B9G69_RS08925	COG0544	peptidyl-prolyl cis-trans isomerase activity
B9G69_RS08935	COG0003	Pfam Anion-transporting ATPase
B9G69_RS08960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B9G69_RS08965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B9G69_RS08970	COG0740	serine-type endopeptidase activity
B9G69_RS08975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B9G69_RS08985	COG2204	response regulator
B9G69_RS08990	COG3852	Histidine kinase
B9G69_RS09010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B9G69_RS09015	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B9G69_RS09020	COG0583	DNA-binding transcription factor activity
B9G69_RS09040	COG1297	OPT oligopeptide transporter protein
B9G69_RS09075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B9G69_RS09080	COG1100	Small GTP-binding protein
B9G69_RS09085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B9G69_RS09090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B9G69_RS09095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B9G69_RS09120	COG2353	YceI-like domain
B9G69_RS09135	COG0538	isocitrate dehydrogenase activity
B9G69_RS09145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B9G69_RS09180	COG1959	2 iron, 2 sulfur cluster binding
B9G69_RS09185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B9G69_RS09195	COG1733	regulation of RNA biosynthetic process
B9G69_RS09200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B9G69_RS09215	COG0596	Alpha beta hydrolase
B9G69_RS09235	COG1971	Probably functions as a manganese efflux pump
B9G69_RS09245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B9G69_RS09250	COG2267	carboxylic ester hydrolase activity
B9G69_RS09275	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS09285	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B9G69_RS09290	COG1573	uracil-dna glycosylase
B9G69_RS09340	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS09345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B9G69_RS09360	COG0427	acetyl-CoA hydrolase
B9G69_RS09380	COG2995	paraquat-inducible protein a
B9G69_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS09470	COG0438	transferase activity, transferring glycosyl groups
B9G69_RS09490	COG1902	pentaerythritol trinitrate reductase activity
B9G69_RS09505	COG4178	(ABC) transporter
B9G69_RS09510	COG1132	(ABC) transporter
B9G69_RS09530	COG1295	ribonuclease BN
B9G69_RS09540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9G69_RS09550	COG4589	Belongs to the CDS family
B9G69_RS09560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B9G69_RS09585	COG0277	FAD linked oxidase domain protein
B9G69_RS09595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B9G69_RS09605	COG1368	sulfuric ester hydrolase activity
B9G69_RS09645	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
B9G69_RS09685	COG1027	Aspartate ammonia-lyase
B9G69_RS09695	COG1902	pentaerythritol trinitrate reductase activity
B9G69_RS09705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9G69_RS09770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9G69_RS09770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9G69_RS09785	COG5002	protein histidine kinase activity
B9G69_RS09785	COG2198	Histidine kinase
B9G69_RS09785	COG0784	Response regulator, receiver
B9G69_RS09790	COG0745	RESPONSE REGULATOR receiver
B9G69_RS09810	COG0724	RNA recognition motif
B9G69_RS09825	COG1271	oxidase subunit
B9G69_RS09845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B9G69_RS09865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B9G69_RS09870	COG0835	chemotaxis
B9G69_RS09915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B9G69_RS09920	COG0786	glutamate:sodium symporter activity
B9G69_RS09960	COG2205	protein histidine kinase activity
B9G69_RS09960	COG2198	Histidine kinase
B9G69_RS09960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G69_RS09960	COG0784	Response regulator, receiver
B9G69_RS09965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B9G69_RS09990	COG1335	isochorismatase
B9G69_RS10010	COG0726	polysaccharide deacetylase
B9G69_RS10035	COG2375	cellular response to nickel ion
B9G69_RS10055	COG2070	2-Nitropropane dioxygenase
B9G69_RS10065	COG0300	oxidoreductase activity
B9G69_RS10080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B9G69_RS10135	COG1960	acyl-CoA dehydrogenase activity
B9G69_RS10150	COG0475	glutathione-regulated potassium exporter activity
B9G69_RS10165	COG0671	phosphoesterase, PA-phosphatase related
B9G69_RS10170	COG0745	RESPONSE REGULATOR receiver
B9G69_RS10175	COG0745	RESPONSE REGULATOR receiver
B9G69_RS10205	COG1192	Involved in chromosome partitioning
B9G69_RS10215	COG0840	transmembrane signaling receptor activity
B9G69_RS10220	COG1366	Belongs to the anti-sigma-factor antagonist family
B9G69_RS10225	COG1366	Belongs to the anti-sigma-factor antagonist family
B9G69_RS10230	COG2172	sigma factor antagonist activity
B9G69_RS10240	COG2198	Histidine kinase
B9G69_RS10240	COG2205	protein histidine kinase activity
B9G69_RS10240	COG0784	Response regulator, receiver
B9G69_RS10245	COG0784	Response regulator, receiver
B9G69_RS10245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G69_RS10245	COG2198	Histidine kinase
B9G69_RS10245	COG2205	protein histidine kinase activity
B9G69_RS10255	COG0789	Transcriptional regulator
B9G69_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS10320	COG1937	Protein conserved in bacteria
B9G69_RS10325	COG2217	Heavy metal translocating P-type atpase
B9G69_RS10330	COG2217	Heavy metal translocating P-type atpase
B9G69_RS10340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B9G69_RS10350	COG2088	sporulation resulting in formation of a cellular spore
B9G69_RS10365	COG0840	transmembrane signaling receptor activity
B9G69_RS10370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9G69_RS10380	COG0501	Belongs to the peptidase M48B family
B9G69_RS10385	COG0714	Associated with various cellular activities
B9G69_RS10405	COG2304	oxidoreductase activity
B9G69_RS10440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B9G69_RS10445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B9G69_RS10470	COG2832	Protein of unknown function (DUF454)
B9G69_RS10485	COG2843	Capsule synthesis protein
B9G69_RS10515	COG0747	negative chemotaxis
B9G69_RS10540	COG0861	Integral membrane protein TerC family
B9G69_RS10555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B9G69_RS10555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B9G69_RS10565	COG0835	chemotaxis
B9G69_RS10565	COG0784	Response regulator, receiver
B9G69_RS10575	COG0242	peptide deformylase activity
B9G69_RS10580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B9G69_RS10595	COG0121	glutamine amidotransferase
B9G69_RS10610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9G69_RS10650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B9G69_RS10655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B9G69_RS10660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9G69_RS10665	COG1116	anion transmembrane transporter activity
B9G69_RS10670	COG2264	protein methyltransferase activity
B9G69_RS10695	COG1181	Belongs to the D-alanine--D-alanine ligase family
B9G69_RS10720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B9G69_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS10735	COG0583	DNA-binding transcription factor activity
B9G69_RS10745	COG0508	dehydrogenase complex catalyzes the overall conversion of
B9G69_RS10755	COG0588	phosphoglycerate mutase activity
B9G69_RS10775	COG1228	amidohydrolase
B9G69_RS10795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B9G69_RS10820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B9G69_RS10860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B9G69_RS10875	COG2967	ApaG domain
B9G69_RS10885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B9G69_RS10920	COG2239	Acts as a magnesium transporter
B9G69_RS10925	COG1132	(ABC) transporter
B9G69_RS10930	COG1132	(ABC) transporter
B9G69_RS10985	COG0302	gtp cyclohydrolase
B9G69_RS10990	COG0308	aminopeptidase N
B9G69_RS11000	COG1289	transmembrane transporter activity
B9G69_RS11015	COG0840	transmembrane signaling receptor activity
B9G69_RS11085	COG2208	phosphoserine phosphatase activity
B9G69_RS11105	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B9G69_RS11110	COG2079	MmgE PrpD family protein
B9G69_RS11145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B9G69_RS11155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B9G69_RS11160	COG0632	four-way junction helicase activity
B9G69_RS11165	COG2255	four-way junction helicase activity
B9G69_RS11175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B9G69_RS11205	COG4264	IucA IucC family
B9G69_RS11230	COG0658	competence protein
B9G69_RS11230	COG2333	competence protein COMEC
B9G69_RS11250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B9G69_RS11250	COG0758	DNA mediated transformation
B9G69_RS11265	COG3118	belongs to the thioredoxin family
B9G69_RS11300	COG0772	Belongs to the SEDS family
B9G69_RS11305	COG0768	penicillin binding
B9G69_RS11315	COG1792	Involved in formation and maintenance of cell shape
B9G69_RS11340	COG0295	cytidine deaminase activity
B9G69_RS11345	COG0424	maF-like protein
B9G69_RS11350	COG1469	GTP cyclohydrolase I activity
B9G69_RS11365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B9G69_RS11380	COG2871	sodium ion transport
B9G69_RS11400	COG0784	Response regulator, receiver
B9G69_RS11400	COG3437	response regulator, receiver
B9G69_RS11440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B9G69_RS11495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B9G69_RS11510	COG1234	tRNA 3'-trailer cleavage
B9G69_RS11555	COG1519	Transferase
B9G69_RS11560	COG0859	PFAM glycosyl transferase family 9
B9G69_RS11580	COG0116	Belongs to the methyltransferase superfamily
B9G69_RS11600	COG0840	transmembrane signaling receptor activity
B9G69_RS11610	COG0586	Pfam SNARE associated Golgi protein
B9G69_RS11620	COG0084	hydrolase, TatD family'
B9G69_RS11625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B9G69_RS11635	COG2226	methyltransferase
B9G69_RS11660	COG2951	lytic endotransglycosylase activity
B9G69_RS11675	COG0633	Ferredoxin
B9G69_RS11675	COG3217	Mosc domain protein beta barrel domain protein
B9G69_RS11685	COG2205	protein histidine kinase activity
B9G69_RS11685	COG4999	Histidine kinase
B9G69_RS11685	COG3850	Histidine kinase
B9G69_RS11685	COG3437	response regulator, receiver
B9G69_RS11710	COG0534	Mate efflux family protein
B9G69_RS11720	COG1830	Aldolase
B9G69_RS11725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B9G69_RS11740	COG2205	protein histidine kinase activity
B9G69_RS11740	COG0784	Response regulator, receiver
B9G69_RS11765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B9G69_RS11780	COG1404	Belongs to the peptidase S8 family
B9G69_RS11790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B9G69_RS11795	COG0215	cysteine-tRNA ligase activity
B9G69_RS11810	COG0556	nucleotide-excision repair
B9G69_RS11815	COG0322	excinuclease ABC activity
B9G69_RS11820	COG0728	peptidoglycan biosynthetic process
B9G69_RS11850	COG2385	sporulation resulting in formation of a cellular spore
B9G69_RS11870	COG4974	Belongs to the 'phage' integrase family
B9G69_RS11890	COG0477	Major facilitator Superfamily
B9G69_RS11910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B9G69_RS11915	COG0545	Peptidyl-prolyl cis-trans isomerase
B9G69_RS11925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G69_RS11925	COG2205	protein histidine kinase activity
B9G69_RS11945	COG0328	RNA-DNA hybrid ribonuclease activity
B9G69_RS11975	COG0348	domain, Protein
B9G69_RS11980	COG2010	Cytochrome c
B9G69_RS11990	COG3278	Belongs to the heme-copper respiratory oxidase family
B9G69_RS12010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B9G69_RS12025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B9G69_RS12050	COG1404	Belongs to the peptidase S8 family
B9G69_RS12055	COG0475	glutathione-regulated potassium exporter activity
B9G69_RS12070	COG1012	belongs to the aldehyde dehydrogenase family
B9G69_RS12090	COG0386	Belongs to the glutathione peroxidase family
B9G69_RS12155	COG1012	belongs to the aldehyde dehydrogenase family
B9G69_RS12160	COG0387	Pfam Sodium calcium exchanger
B9G69_RS12165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B9G69_RS12170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B9G69_RS12190	COG0288	reversible hydration of carbon dioxide
B9G69_RS12205	COG2814	Major facilitator Superfamily
B9G69_RS12215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B9G69_RS12220	COG1720	tRNA m6t6A37 methyltransferase activity
B9G69_RS12250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9G69_RS12255	COG0189	ligase activity
B9G69_RS12270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B9G69_RS12280	COG0584	glycerophosphoryl diester phosphodiesterase
B9G69_RS12290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9G69_RS12295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9G69_RS12305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9G69_RS12310	COG0601	transmembrane transport
B9G69_RS12315	COG0747	negative chemotaxis
B9G69_RS12320	COG0616	signal peptide processing
B9G69_RS12345	COG0583	DNA-binding transcription factor activity
B9G69_RS12395	COG0625	glutathione transferase activity
B9G69_RS12400	COG1309	transcriptional regulator
B9G69_RS12405	COG3040	lipid binding
B9G69_RS12410	COG0142	geranyltranstransferase activity
B9G69_RS12420	COG1562	ergosterol biosynthetic process
B9G69_RS12435	COG1131	(ABC) transporter
B9G69_RS12485	COG2124	cytochrome p450
B9G69_RS12495	COG3546	catalase activity
B9G69_RS12525	COG2814	Major facilitator Superfamily
B9G69_RS12565	COG1834	amidinotransferase
B9G69_RS12605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B9G69_RS12615	COG1960	acyl-CoA dehydrogenase activity
B9G69_RS12650	COG1253	flavin adenine dinucleotide binding
B9G69_RS12660	COG1418	mRNA catabolic process
B9G69_RS12675	COG2814	Major facilitator Superfamily
B9G69_RS12685	COG0730	response to heat
B9G69_RS12725	COG0038	chloride channel
B9G69_RS12735	COG2197	response regulator
B9G69_RS12750	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B9G69_RS12750	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B9G69_RS12765	COG0443	Heat shock 70 kDa protein
B9G69_RS12785	COG2176	DNA-directed DNA polymerase activity
B9G69_RS12790	COG0477	Major facilitator Superfamily
B9G69_RS12850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B9G69_RS12865	COG0318	PFAM AMP-dependent synthetase and ligase
B9G69_RS12875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B9G69_RS12885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B9G69_RS12890	COG0326	Molecular chaperone. Has ATPase activity
B9G69_RS12895	COG3483	tryptophan 2,3-dioxygenase activity
B9G69_RS12925	COG2900	Belongs to the SlyX family
B9G69_RS12930	COG0038	chloride channel
B9G69_RS12950	COG0617	tRNA 3'-terminal CCA addition
B9G69_RS12980	COG2197	response regulator
B9G69_RS12985	COG1607	acyl-coa hydrolase
B9G69_RS13005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B9G69_RS13010	COG0280	phosphate acetyltransferase
B9G69_RS13055	COG3387	PFAM Glycoside hydrolase 15-related
B9G69_RS13060	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B9G69_RS13065	COG3104	oligopeptide transport
B9G69_RS13120	COG5002	protein histidine kinase activity
B9G69_RS13120	COG2198	Histidine kinase
B9G69_RS13120	COG0784	Response regulator, receiver
B9G69_RS13130	COG1404	Belongs to the peptidase S8 family
B9G69_RS13150	COG1201	RNA secondary structure unwinding
B9G69_RS13155	COG1793	dna ligase
B9G69_RS13170	COG1335	isochorismatase
B9G69_RS13195	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9G69_RS13200	COG1024	Enoyl-CoA hydratase
B9G69_RS13205	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9G69_RS13205	COG1703	isobutyryl-CoA mutase activity
B9G69_RS13205	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9G69_RS13225	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B9G69_RS13240	COG0720	synthase
B9G69_RS13270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B9G69_RS13285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B9G69_RS13290	COG1131	(ABC) transporter
B9G69_RS13295	COG1131	(ABC) transporter
B9G69_RS13300	COG0842	Transport permease protein
B9G69_RS13300	COG1129	ABC transporter
B9G69_RS13305	COG0842	Transport permease protein
B9G69_RS13315	COG1999	signal sequence binding
B9G69_RS13370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B9G69_RS13380	COG1215	transferase activity, transferring glycosyl groups
B9G69_RS13385	COG0726	polysaccharide deacetylase
B9G69_RS13385	COG1649	PFAM Uncharacterised BCR, COG1649
B9G69_RS13420	COG0471	metal ion transport
B9G69_RS13440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B9G69_RS13445	COG0824	Thioesterase
B9G69_RS13450	COG1494	fructose-1,6-bisphosphatase
B9G69_RS13490	COG1012	belongs to the aldehyde dehydrogenase family
B9G69_RS13495	COG0037	tRNA processing
B9G69_RS13500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9G69_RS13505	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B9G69_RS13515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B9G69_RS13520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B9G69_RS13525	COG0802	atpase or kinase
B9G69_RS13530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B9G69_RS13550	COG0482	sulfurtransferase activity
B9G69_RS13555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9G69_RS13560	COG0571	ribonuclease III activity
B9G69_RS13565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B9G69_RS13570	COG1160	GTP binding
B9G69_RS13575	COG0733	neurotransmitter:sodium symporter activity
B9G69_RS13585	COG0386	Belongs to the glutathione peroxidase family
B9G69_RS13595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B9G69_RS13605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B9G69_RS13610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B9G69_RS13620	COG0840	transmembrane signaling receptor activity
B9G69_RS13625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B9G69_RS13630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B9G69_RS13640	COG2814	Major facilitator Superfamily
B9G69_RS13665	COG2166	iron-sulfur cluster assembly
B9G69_RS13690	COG2166	iron-sulfur cluster assembly
B9G69_RS13705	COG0217	transcriptional regulatory protein
B9G69_RS13715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G69_RS13730	COG1187	pseudouridine synthase activity
B9G69_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS13760	COG1716	ATPase activity
B9G69_RS13760	COG5001	Diguanylate cyclase
B9G69_RS13770	COG1960	acyl-CoA dehydrogenase activity
B9G69_RS13775	COG1994	Peptidase M50
B9G69_RS13780	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B9G69_RS13785	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B9G69_RS13810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B9G69_RS13815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B9G69_RS13815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B9G69_RS13820	COG1242	4 iron, 4 sulfur cluster binding
B9G69_RS13875	COG0848	biopolymer transport protein
B9G69_RS13880	COG0811	peptide transport
B9G69_RS13895	COG0431	NADPH-dependent FMN reductase
B9G69_RS13905	COG3158	transport of potassium into the cell
B9G69_RS13930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B9G69_RS13935	COG0698	ribose 5-phosphate isomerase
B9G69_RS13940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B9G69_RS13945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B9G69_RS13950	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS13955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B9G69_RS13960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B9G69_RS13965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B9G69_RS13980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9G69_RS13985	COG1116	anion transmembrane transporter activity
B9G69_RS14000	COG0582	viral genome integration into host DNA
B9G69_RS14010	COG0018	arginyl-trna synthetase
B9G69_RS14075	COG2076	Multidrug Resistance protein
B9G69_RS14080	COG0431	NADPH-dependent FMN reductase
B9G69_RS14085	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B9G69_RS14090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B9G69_RS14095	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B9G69_RS14100	COG2205	protein histidine kinase activity
B9G69_RS14105	COG0745	RESPONSE REGULATOR receiver
B9G69_RS14135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B9G69_RS14140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B9G69_RS14150	COG4591	ABC-type transport system involved in lipoprotein release permease component
B9G69_RS14155	COG2171	N-acyltransferase activity
B9G69_RS14165	COG0019	diaminopimelate decarboxylase activity
B9G69_RS14170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B9G69_RS14175	COG0517	IMP dehydrogenase activity
B9G69_RS14175	COG0516	GMP reductase activity
B9G69_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
B9G69_RS14235	COG1054	Belongs to the UPF0176 family
B9G69_RS14240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B9G69_RS14245	COG1131	(ABC) transporter
B9G69_RS14250	COG0842	Transport permease protein
B9G69_RS14255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B9G69_RS14260	COG0228	four-way junction DNA binding
B9G69_RS14270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B9G69_RS14275	COG0336	Belongs to the RNA methyltransferase TrmD family
B9G69_RS14280	COG0336	Belongs to the RNA methyltransferase TrmD family
B9G69_RS14280	COG4752	Belongs to the RNA methyltransferase TrmD family
B9G69_RS14285	COG0335	large ribosomal subunit rRNA binding
B9G69_RS14290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B9G69_RS14300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B9G69_RS14335	COG0776	regulation of translation
B9G69_RS14375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B9G69_RS14380	COG0183	Belongs to the thiolase family
B9G69_RS14410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9G69_RS14420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B9G69_RS14420	COG4651	solute:proton antiporter activity
B9G69_RS14425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B9G69_RS14430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B9G69_RS14435	COG0516	GMP reductase activity
B9G69_RS14435	COG0517	IMP dehydrogenase activity
B9G69_RS14440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B9G69_RS14440	COG0519	Catalyzes the synthesis of GMP from XMP
B9G69_RS14480	COG0017	Asparaginyl-tRNA synthetase
B9G69_RS14495	COG0625	glutathione transferase activity
B9G69_RS14500	COG0037	tRNA processing
B9G69_RS14530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B9G69_RS14560	COG1837	Belongs to the UPF0109 family
B9G69_RS14590	COG2801	Transposase and inactivated derivatives
B9G69_RS14600	COG3932	Exopolysaccharide synthesis, ExoD
B9G69_RS14610	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B9G69_RS14650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B9G69_RS14685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B9G69_RS14695	COG0438	transferase activity, transferring glycosyl groups
B9G69_RS14710	COG0662	Cupin 2, conserved barrel domain protein
B9G69_RS14710	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B9G69_RS14745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B9G69_RS14750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B9G69_RS14775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B9G69_RS14785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B9G69_RS14805	COG0463	Glycosyl transferase, family 2
B9G69_RS14825	COG1215	transferase activity, transferring glycosyl groups
B9G69_RS14840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B9G69_RS14845	COG0581	inorganic phosphate transmembrane transporter activity
B9G69_RS14850	COG0573	inorganic phosphate transmembrane transporter activity
B9G69_RS14855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B9G69_RS14875	COG0735	belongs to the Fur family
B9G69_RS14890	COG1090	epimerase
B9G69_RS14895	COG0415	Belongs to the DNA photolyase family
B9G69_RS14900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B9G69_RS14905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B9G69_RS14935	COG1612	heme a metabolic process
B9G69_RS14935	COG0109	protoheme IX farnesyltransferase activity
B9G69_RS14940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B9G69_RS14950	COG0494	nUDIX hydrolase
B9G69_RS14980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B9G69_RS14990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B9G69_RS14995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B9G69_RS15000	COG1862	Preprotein translocase
B9G69_RS15005	COG0343	queuine tRNA-ribosyltransferase activity
B9G69_RS15085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B9G69_RS15110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9G69_RS15130	COG0784	Response regulator, receiver
B9G69_RS15130	COG2205	protein histidine kinase activity
B9G69_RS15135	COG2205	protein histidine kinase activity
B9G69_RS15135	COG0784	Response regulator, receiver
B9G69_RS15170	COG0776	regulation of translation
B9G69_RS15175	COG0072	phenylalanine-tRNA ligase activity
B9G69_RS15175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9G69_RS15180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B9G69_RS15190	COG0357	Ribosomal RNA small subunit methyltransferase G
B9G69_RS15195	COG0357	Ribosomal RNA small subunit methyltransferase G
B9G69_RS15195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B9G69_RS15205	COG1597	lipid kinase activity
B9G69_RS15240	COG1136	(ABC) transporter
B9G69_RS15275	COG1304	FMN binding
B9G69_RS15280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B9G69_RS15285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B9G69_RS15305	COG0584	glycerophosphoryl diester phosphodiesterase
B9G69_RS15330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B9G69_RS15335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B9G69_RS15375	COG0437	4 iron, 4 sulfur cluster binding
B9G69_RS15385	COG1333	cytochrome c biogenesis protein
B9G69_RS15385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B9G69_RS15390	COG1333	cytochrome c biogenesis protein
B9G69_RS15390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B9G69_RS15400	COG2096	Adenosyltransferase
B9G69_RS15430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B9G69_RS15435	COG0138	bifunctional purine biosynthesis protein purh
B9G69_RS15440	COG0047	phosphoribosylformylglycinamidine synthase activity
B9G69_RS15445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B9G69_RS15450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B9G69_RS15455	COG0151	Belongs to the GarS family
B9G69_RS15465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B9G69_RS15500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B9G69_RS15505	COG1459	type II secretion system
B9G69_RS15510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B9G69_RS15575	COG4191	Histidine kinase
B9G69_RS15585	COG1758	RNA polymerase activity
B9G69_RS15590	COG0194	GDP metabolic process
B9G69_RS15595	COG1561	YicC-like family, N-terminal region
B9G69_RS15600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B9G69_RS15605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B9G69_RS15620	COG1216	Glycosyl transferase, family 2
B9G69_RS15645	COG0756	dUTP diphosphatase activity
B9G69_RS15655	COG1185	polyribonucleotide nucleotidyltransferase activity
B9G69_RS15660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B9G69_RS15665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B9G69_RS15670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B9G69_RS15675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B9G69_RS15680	COG0195	Participates in both transcription termination and antitermination
B9G69_RS15685	COG0779	Required for maturation of 30S ribosomal subunits
B9G69_RS15755	COG0564	pseudouridine synthase activity
B9G69_RS15770	COG1404	Belongs to the peptidase S8 family
B9G69_RS15805	COG0604	alcohol dehydrogenase
B9G69_RS15815	COG0412	Dienelactone hydrolase
B9G69_RS15830	COG2204	response regulator
B9G69_RS15835	COG3852	Histidine kinase
B9G69_RS15840	COG1459	type II secretion system
B9G69_RS15850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B9G69_RS15860	COG0196	riboflavin kinase activity
B9G69_RS15865	COG2205	protein histidine kinase activity
B9G69_RS15870	COG2204	response regulator
B9G69_RS15875	COG0859	PFAM glycosyl transferase family 9
B9G69_RS15895	COG1560	Kdo2-lipid A biosynthetic process
B9G69_RS15900	COG1663	tetraacyldisaccharide 4'-kinase activity
B9G69_RS15915	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9G69_RS15925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9G69_RS15945	COG1215	transferase activity, transferring glycosyl groups
B9G69_RS15955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B9G69_RS15970	COG0071	Belongs to the small heat shock protein (HSP20) family
B9G69_RS15995	COG1733	regulation of RNA biosynthetic process
B9G69_RS16000	COG0702	epimerase
B9G69_RS16005	COG0708	Exodeoxyribonuclease III
B9G69_RS16020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9G69_RS16025	COG0840	transmembrane signaling receptor activity
B9G69_RS16045	COG1741	Belongs to the pirin family
B9G69_RS16055	COG1335	isochorismatase
B9G69_RS16060	COG0583	DNA-binding transcription factor activity
B9G69_RS16090	COG0038	chloride channel
B9G69_RS16140	COG0488	(ABC) transporter
B9G69_RS16170	COG0667	Aldo Keto reductase
B9G69_RS16175	COG0514	ATP-dependent DNA helicase (RecQ)
B9G69_RS16220	COG2234	aminopeptidase activity
B9G69_RS16225	COG0583	DNA-binding transcription factor activity
B9G69_RS16255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B9G69_RS16280	COG0415	Belongs to the DNA photolyase family
B9G69_RS16310	COG4555	ABC transporter
B9G69_RS16340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B9G69_RS16345	COG1024	Enoyl-CoA hydratase
B9G69_RS16355	COG0439	Biotin carboxylase
B9G69_RS16360	COG5016	pyruvate
B9G69_RS16360	COG0511	ligase activity, forming carbon-carbon bonds
B9G69_RS16380	COG0488	(ABC) transporter
B9G69_RS16400	COG0488	(ABC) transporter
B9G69_RS16405	COG1683	Conserved Protein
B9G69_RS16410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B9G69_RS16415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B9G69_RS16425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B9G69_RS16430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B9G69_RS16470	COG2897	thiosulfate sulfurtransferase activity
B9G69_RS16515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9G69_RS16550	COG0708	Exodeoxyribonuclease III
B9G69_RS16560	COG0768	penicillin binding
B9G69_RS16565	COG1309	transcriptional regulator
B9G69_RS16585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9G69_RS16600	COG0667	Aldo Keto reductase
B9G69_RS16610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B9G69_RS16620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B9G69_RS16630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B9G69_RS16635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B9G69_RS16645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B9G69_RS16655	COG2226	methyltransferase
B9G69_RS16660	COG1605	Chorismate mutase
B9G69_RS16660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B9G69_RS16670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B9G69_RS16675	COG0596	Alpha beta hydrolase
B9G69_RS16700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B9G69_RS16705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B9G69_RS16720	COG0835	chemotaxis
B9G69_RS16725	COG0643	Histidine kinase
B9G69_RS16725	COG2198	Histidine kinase
B9G69_RS16730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B9G69_RS16735	COG2201	protein-glutamate methylesterase activity
B9G69_RS16740	COG4999	Histidine kinase
B9G69_RS16740	COG3850	Histidine kinase
B9G69_RS16740	COG3437	response regulator, receiver
B9G69_RS16740	COG2205	protein histidine kinase activity
B9G69_RS16745	COG0617	tRNA 3'-terminal CCA addition
B9G69_RS16750	COG0596	Alpha beta hydrolase
B9G69_RS16765	COG1346	cytolysis
B9G69_RS16785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B9G69_RS16795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B9G69_RS16815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B9G69_RS16820	COG0181	hydroxymethylbilane synthase activity
B9G69_RS16825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B9G69_RS16830	COG0113	porphobilinogen synthase activity
B9G69_RS16870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B9G69_RS16895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B9G69_RS16900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B9G69_RS16910	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B9G69_RS16915	COG1435	thymidine kinase activity
B9G69_RS16930	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B9G69_RS16955	COG1127	ABC transporter
B9G69_RS16960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B9G69_RS16975	COG2204	response regulator
B9G69_RS16980	COG1815	bacterial-type flagellum-dependent cell motility
B9G69_RS16990	COG1677	Flagellar hook-basal body complex protein FliE
B9G69_RS17000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B9G69_RS17010	COG1157	protein secretion by the type III secretion system
B9G69_RS17030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B9G69_RS17045	COG0745	RESPONSE REGULATOR receiver
B9G69_RS17075	COG0559	Belongs to the binding-protein-dependent transport system permease family
B9G69_RS17085	COG0205	6-phosphofructokinase activity
B9G69_RS17095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B9G69_RS17105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B9G69_RS17120	COG1121	(ABC) transporter
B9G69_RS17125	COG0803	Belongs to the bacterial solute-binding protein 9 family
B9G69_RS17135	COG5000	phosphorelay sensor kinase activity
B9G69_RS17140	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B9G69_RS17145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B9G69_RS17175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9G69_RS17180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B9G69_RS17235	COG0497	DNA recombination
B9G69_RS17240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B9G69_RS17245	COG0339	signal peptide processing
B9G69_RS17280	COG1022	Amp-dependent synthetase and ligase
B9G69_RS17290	COG0237	dephospho-CoA kinase activity
B9G69_RS17340	COG0328	RNA-DNA hybrid ribonuclease activity
B9G69_RS17345	COG0300	oxidoreductase activity
B9G69_RS17375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B9G69_RS17380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B9G69_RS17385	COG1127	ABC transporter
B9G69_RS17390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B9G69_RS17405	COG3481	metal-dependent phosphohydrolase, HD sub domain
B9G69_RS17410	COG1045	serine acetyltransferase
B9G69_RS17425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B9G69_RS17435	COG1643	Atp-dependent helicase
B9G69_RS17455	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B9G69_RS17460	COG3639	organic phosphonate transmembrane transporter activity
B9G69_RS17480	COG1132	(ABC) transporter
B9G69_RS17485	COG1132	(ABC) transporter
B9G69_RS17535	COG3220	belongs to the UPF0276 family
B9G69_RS17545	COG1733	regulation of RNA biosynthetic process
B9G69_RS17550	COG3631	Ketosteroid isomerase-related protein
B9G69_RS17560	COG2207	Transcriptional regulator
B9G69_RS17570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9G69_RS17580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9G69_RS17580	COG0649	NAD binding
B9G69_RS17595	COG1034	ATP synthesis coupled electron transport
B9G69_RS17600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9G69_RS17625	COG0583	DNA-binding transcription factor activity
B9G69_RS17655	COG1381	Involved in DNA repair and RecF pathway recombination
B9G69_RS17660	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B9G69_RS17665	COG2204	response regulator
B9G69_RS17685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B9G69_RS17695	COG0542	response to heat
B9G69_RS17710	COG2204	response regulator
B9G69_RS17720	COG0307	riboflavin synthase, alpha
B9G69_RS17725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B9G69_RS17725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B9G69_RS17730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B9G69_RS17735	COG5000	phosphorelay sensor kinase activity
B9G69_RS17740	COG2204	response regulator
B9G69_RS17745	COG0442	prolyl-tRNA aminoacylation
B9G69_RS17755	COG0284	orotidine-5'-phosphate decarboxylase activity
B9G69_RS17785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B9G69_RS17795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B9G69_RS17800	COG0250	Participates in transcription elongation, termination and antitermination
B9G69_RS17805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B9G69_RS17810	COG0081	regulation of translation
B9G69_RS17815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B9G69_RS17820	COG0222	ribosome binding
B9G69_RS17825	COG0085	RNA polymerase activity
B9G69_RS17830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B9G69_RS17835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B9G69_RS17840	COG0049	tRNA binding
B9G69_RS17845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B9G69_RS17850	COG0051	transcription antitermination factor activity, RNA binding
B9G69_RS17855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B9G69_RS17860	COG0088	Forms part of the polypeptide exit tunnel
B9G69_RS17865	COG0089	rRNA binding
B9G69_RS17870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B9G69_RS17875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B9G69_RS17880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B9G69_RS17885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B9G69_RS17890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B9G69_RS17895	COG0255	Belongs to the universal ribosomal protein uL29 family
B9G69_RS17900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B9G69_RS17905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B9G69_RS17910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B9G69_RS17915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B9G69_RS17920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B9G69_RS17925	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B9G69_RS17930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B9G69_RS17935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B9G69_RS17940	COG1841	ribosomal large subunit assembly
B9G69_RS17945	COG0200	Binds to the 23S rRNA
B9G69_RS17950	COG0201	protein transport
B9G69_RS17955	COG0563	adenylate kinase activity
B9G69_RS17960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B9G69_RS17965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B9G69_RS17970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B9G69_RS17975	COG0202	RNA polymerase activity
B9G69_RS17980	COG0203	ribosomal protein L17
B9G69_RS17985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B9G69_RS18000	COG2205	protein histidine kinase activity
B9G69_RS18000	COG0784	Response regulator, receiver
B9G69_RS18000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G69_RS18000	COG2198	Histidine kinase
B9G69_RS18015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B9G69_RS18025	COG0662	Cupin 2, conserved barrel domain protein
B9G69_RS18025	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B9G69_RS18050	COG1960	acyl-CoA dehydrogenase activity
B9G69_RS18070	COG0840	transmembrane signaling receptor activity
B9G69_RS18090	COG0366	Alpha amylase catalytic
B9G69_RS18105	COG0714	Associated with various cellular activities