locus-tag	class	description
DOM22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DOM22_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DOM22_RS00020	COG0187	DNA topoisomerase II activity
DOM22_RS00045	COG0356	it plays a direct role in the translocation of protons across the membrane
DOM22_RS00050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOM22_RS00055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DOM22_RS00065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DOM22_RS00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOM22_RS00080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOM22_RS00090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DOM22_RS00095	COG2086	electron transfer activity
DOM22_RS00105	COG1053	succinate dehydrogenase
DOM22_RS00130	COG2267	carboxylic ester hydrolase activity
DOM22_RS00140	COG0360	Binds together with S18 to 16S ribosomal RNA
DOM22_RS00150	COG0359	binds to the 23S rRNA
DOM22_RS00170	COG0300	oxidoreductase activity
DOM22_RS00175	COG0305	Participates in initiation and elongation during chromosome replication
DOM22_RS00185	COG0602	queuosine metabolic process
DOM22_RS00190	COG1674	ftsk spoiiie
DOM22_RS00210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DOM22_RS00215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DOM22_RS00220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DOM22_RS00230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DOM22_RS00260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DOM22_RS00270	COG0154	amidase activity
DOM22_RS00275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DOM22_RS00280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DOM22_RS00280	COG0248	Ppx GppA phosphatase
DOM22_RS00300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DOM22_RS00310	COG0254	rRNA binding
DOM22_RS00315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DOM22_RS00320	COG2890	protein-(glutamine-N5) methyltransferase activity
DOM22_RS00325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DOM22_RS00350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DOM22_RS00370	COG0586	Pfam SNARE associated Golgi protein
DOM22_RS00395	COG0590	tRNA wobble adenosine to inosine editing
DOM22_RS00405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DOM22_RS00410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DOM22_RS00425	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DOM22_RS00480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DOM22_RS00485	COG0318	PFAM AMP-dependent synthetase and ligase
DOM22_RS00495	COG0574	Belongs to the PEP-utilizing enzyme family
DOM22_RS00495	COG3848	Pyruvate phosphate dikinase
DOM22_RS00515	COG1136	(ABC) transporter
DOM22_RS00570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DOM22_RS00575	COG0459	protein refolding
DOM22_RS00590	COG2201	protein-glutamate methylesterase activity
DOM22_RS00670	COG0840	transmembrane signaling receptor activity
DOM22_RS00675	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DOM22_RS00695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DOM22_RS00700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOM22_RS00710	COG1012	belongs to the aldehyde dehydrogenase family
DOM22_RS00715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DOM22_RS00725	COG0527	aspartate kinase activity
DOM22_RS00735	COG0840	transmembrane signaling receptor activity
DOM22_RS00740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOM22_RS00745	COG1217	gtp-binding protein TYPA
DOM22_RS00750	COG1131	(ABC) transporter
DOM22_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOM22_RS00765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOM22_RS00770	COG0671	phosphoesterase, PA-phosphatase related
DOM22_RS00775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DOM22_RS00780	COG1360	Flagellar Motor Protein
DOM22_RS00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOM22_RS00815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DOM22_RS00820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DOM22_RS00825	COG0823	Involved in the tonB-independent uptake of proteins
DOM22_RS00855	COG0719	Fe-S assembly protein
DOM22_RS00860	COG0396	ATPase activity
DOM22_RS00865	COG0719	Fe-S assembly protein
DOM22_RS00870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DOM22_RS00895	COG1570	exodeoxyribonuclease VII activity
DOM22_RS00900	COG1722	exodeoxyribonuclease VII activity
DOM22_RS00905	COG0142	geranyltranstransferase activity
DOM22_RS00910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DOM22_RS00920	COG0006	proline dipeptidase activity
DOM22_RS00945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DOM22_RS00950	COG1077	Cell shape determining protein MreB Mrl
DOM22_RS00965	COG5002	protein histidine kinase activity
DOM22_RS01000	COG2003	Belongs to the UPF0758 family
DOM22_RS01015	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DOM22_RS01040	COG2766	serine protein kinase
DOM22_RS01045	COG2718	Belongs to the UPF0229 family
DOM22_RS01050	COG2719	SpoVR family
DOM22_RS01060	COG0745	RESPONSE REGULATOR receiver
DOM22_RS01075	COG0590	tRNA wobble adenosine to inosine editing
DOM22_RS01085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DOM22_RS01090	COG1610	YqeY-like protein
DOM22_RS01095	COG0358	DNA primase activity
DOM22_RS01115	COG1607	acyl-coa hydrolase
DOM22_RS01130	COG0835	chemotaxis
DOM22_RS01135	COG0840	transmembrane signaling receptor activity
DOM22_RS01140	COG3290	protein histidine kinase activity
DOM22_RS01160	COG0582	viral genome integration into host DNA
DOM22_RS01210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DOM22_RS01250	COG1064	alcohol dehydrogenase
DOM22_RS01255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOM22_RS01275	COG0509	glycine decarboxylation via glycine cleavage system
DOM22_RS01285	COG0347	Belongs to the P(II) protein family
DOM22_RS01295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DOM22_RS01300	COG0653	protein targeting
DOM22_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS01350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DOM22_RS01350	COG1845	cytochrome c oxidase, subunit III
DOM22_RS01355	COG1845	cytochrome c oxidase, subunit III
DOM22_RS01365	COG0109	protoheme IX farnesyltransferase activity
DOM22_RS01390	COG2032	superoxide dismutase activity
DOM22_RS01415	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DOM22_RS01425	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DOM22_RS01450	COG0357	Ribosomal RNA small subunit methyltransferase G
DOM22_RS01465	COG0513	Belongs to the DEAD box helicase family
DOM22_RS01470	COG1061	Type III restriction enzyme res subunit
DOM22_RS01500	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DOM22_RS01510	COG2070	2-Nitropropane dioxygenase
DOM22_RS01530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DOM22_RS01540	COG1393	Belongs to the ArsC family
DOM22_RS01570	COG0505	Belongs to the CarA family
DOM22_RS01605	COG0513	Belongs to the DEAD box helicase family
DOM22_RS01615	COG2855	membrane
DOM22_RS01620	COG0656	L-ascorbic acid biosynthetic process
DOM22_RS01635	COG2223	nitrite transmembrane transporter activity
DOM22_RS01650	COG1047	Peptidyl-prolyl cis-trans
DOM22_RS01655	COG1666	GTP binding
DOM22_RS01660	COG0724	RNA recognition motif
DOM22_RS01670	COG1136	(ABC) transporter
DOM22_RS01680	COG0009	L-threonylcarbamoyladenylate synthase
DOM22_RS01695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOM22_RS01700	COG1393	Belongs to the ArsC family
DOM22_RS01705	COG0010	Belongs to the arginase family
DOM22_RS01710	COG4166	transmembrane transport
DOM22_RS01715	COG4174	ABC transporter (Permease)
DOM22_RS01720	COG4239	(ABC) transporter, permease
DOM22_RS01735	COG1166	arginine decarboxylase activity
DOM22_RS01740	COG0495	leucyl-tRNA aminoacylation
DOM22_RS01750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DOM22_RS01755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DOM22_RS01765	COG0492	ferredoxin-NADP+ reductase activity
DOM22_RS01830	COG0587	DNA-directed DNA polymerase activity
DOM22_RS01875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DOM22_RS01900	COG0739	heme binding
DOM22_RS01920	COG0183	Belongs to the thiolase family
DOM22_RS01940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOM22_RS01945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOM22_RS01960	COG0583	DNA-binding transcription factor activity
DOM22_RS01965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DOM22_RS01970	COG0557	exoribonuclease II activity
DOM22_RS01990	COG0840	transmembrane signaling receptor activity
DOM22_RS02000	COG1079	Belongs to the binding-protein-dependent transport system permease family
DOM22_RS02005	COG4603	Belongs to the binding-protein-dependent transport system permease family
DOM22_RS02010	COG3845	ABC transporter
DOM22_RS02015	COG1744	ABC transporter substrate-binding protein PnrA-like
DOM22_RS02020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOM22_RS02040	COG0525	valine-tRNA ligase activity
DOM22_RS02065	COG1872	DUF167
DOM22_RS02075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DOM22_RS02080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DOM22_RS02095	COG0424	maF-like protein
DOM22_RS02120	COG1716	ATPase activity
DOM22_RS02165	COG1183	phosphatidylcholine synthase activity
DOM22_RS02170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DOM22_RS02200	COG0101	tRNA pseudouridine synthase activity
DOM22_RS02205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DOM22_RS02210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DOM22_RS02220	COG1505	serine-type exopeptidase activity
DOM22_RS02235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DOM22_RS02245	COG1408	metallophosphoesterase
DOM22_RS02250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DOM22_RS02260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DOM22_RS02265	COG1058	Belongs to the CinA family
DOM22_RS02265	COG1546	Belongs to the CinA family
DOM22_RS02270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DOM22_RS02310	COG0386	Belongs to the glutathione peroxidase family
DOM22_RS02330	COG4786	Flagellar basal body rod
DOM22_RS02335	COG4786	Flagellar basal body rod
DOM22_RS02350	COG1706	bacterial-type flagellum-dependent cell motility
DOM22_RS02370	COG1256	bacterial-type flagellum assembly
DOM22_RS02375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOM22_RS02385	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DOM22_RS02405	COG1575	Belongs to the MenA family. Type 1 subfamily
DOM22_RS02415	COG0318	PFAM AMP-dependent synthetase and ligase
DOM22_RS02435	COG0824	Thioesterase
DOM22_RS02440	COG0142	geranyltranstransferase activity
DOM22_RS02450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOM22_RS02485	COG0372	Belongs to the citrate synthase family
DOM22_RS02500	COG0537	adenosine 5'-monophosphoramidase activity
DOM22_RS02530	COG0643	Histidine kinase
DOM22_RS02530	COG2198	Histidine kinase
DOM22_RS02540	COG2201	protein-glutamate methylesterase activity
DOM22_RS02555	COG1181	Belongs to the D-alanine--D-alanine ligase family
DOM22_RS02560	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DOM22_RS02580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DOM22_RS02600	COG3842	ATPase activity
DOM22_RS02625	COG2205	protein histidine kinase activity
DOM22_RS02625	COG0784	Response regulator, receiver
DOM22_RS02635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOM22_RS02650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOM22_RS02660	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DOM22_RS02665	COG1516	flagellar protein fliS
DOM22_RS02710	COG0742	ribosomal rna small subunit methyltransferase
DOM22_RS02715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DOM22_RS02720	COG0436	Aminotransferase
DOM22_RS02795	COG5640	endopeptidase activity
DOM22_RS02815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DOM22_RS02830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOM22_RS02850	COG0745	RESPONSE REGULATOR receiver
DOM22_RS02870	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS02890	COG0726	polysaccharide deacetylase
DOM22_RS02900	COG0726	polysaccharide deacetylase
DOM22_RS02920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DOM22_RS02920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DOM22_RS02930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DOM22_RS02935	COG2264	protein methyltransferase activity
DOM22_RS02965	COG1187	pseudouridine synthase activity
DOM22_RS03005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DOM22_RS03010	COG1360	Flagellar Motor Protein
DOM22_RS03025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DOM22_RS03030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DOM22_RS03040	COG0739	heme binding
DOM22_RS03040	COG0741	lytic transglycosylase activity
DOM22_RS03040	COG1196	nuclear chromosome segregation
DOM22_RS03060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DOM22_RS03075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DOM22_RS03085	COG2119	membrane
DOM22_RS03090	COG0724	RNA recognition motif
DOM22_RS03095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DOM22_RS03110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DOM22_RS03120	COG0275	rRNA processing
DOM22_RS03130	COG0768	penicillin binding
DOM22_RS03160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DOM22_RS03165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DOM22_RS03185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DOM22_RS03190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DOM22_RS03205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DOM22_RS03210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DOM22_RS03235	COG0840	transmembrane signaling receptor activity
DOM22_RS03250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DOM22_RS03255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOM22_RS03335	COG0497	DNA recombination
DOM22_RS03340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DOM22_RS03345	COG0339	signal peptide processing
DOM22_RS03365	COG1022	Amp-dependent synthetase and ligase
DOM22_RS03375	COG0237	dephospho-CoA kinase activity
DOM22_RS03420	COG1074	ATP-dependent DNA helicase activity
DOM22_RS03425	COG0328	RNA-DNA hybrid ribonuclease activity
DOM22_RS03430	COG0300	oxidoreductase activity
DOM22_RS03450	COG2205	protein histidine kinase activity
DOM22_RS03460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DOM22_RS03465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOM22_RS03470	COG1127	ABC transporter
DOM22_RS03475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DOM22_RS03490	COG3481	metal-dependent phosphohydrolase, HD sub domain
DOM22_RS03495	COG1045	serine acetyltransferase
DOM22_RS03510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DOM22_RS03525	COG1643	Atp-dependent helicase
DOM22_RS03545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DOM22_RS03550	COG3639	organic phosphonate transmembrane transporter activity
DOM22_RS03570	COG1132	(ABC) transporter
DOM22_RS03575	COG1132	(ABC) transporter
DOM22_RS03605	COG1252	NADH dehydrogenase
DOM22_RS03625	COG3220	belongs to the UPF0276 family
DOM22_RS03630	COG2353	YceI-like domain
DOM22_RS03640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOM22_RS03645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOM22_RS03645	COG0649	NAD binding
DOM22_RS03660	COG1034	ATP synthesis coupled electron transport
DOM22_RS03665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOM22_RS03695	COG0583	DNA-binding transcription factor activity
DOM22_RS03725	COG1381	Involved in DNA repair and RecF pathway recombination
DOM22_RS03730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DOM22_RS03735	COG2204	response regulator
DOM22_RS03755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOM22_RS03765	COG0542	response to heat
DOM22_RS03790	COG0307	riboflavin synthase, alpha
DOM22_RS03795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DOM22_RS03795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DOM22_RS03800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DOM22_RS03805	COG5000	phosphorelay sensor kinase activity
DOM22_RS03810	COG2204	response regulator
DOM22_RS03815	COG0442	prolyl-tRNA aminoacylation
DOM22_RS03825	COG0284	orotidine-5'-phosphate decarboxylase activity
DOM22_RS03830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOM22_RS03855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DOM22_RS03870	COG0250	Participates in transcription elongation, termination and antitermination
DOM22_RS03875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DOM22_RS03880	COG0081	regulation of translation
DOM22_RS03885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DOM22_RS03890	COG0222	ribosome binding
DOM22_RS03895	COG0085	RNA polymerase activity
DOM22_RS03900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DOM22_RS03905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DOM22_RS03910	COG0049	tRNA binding
DOM22_RS03915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DOM22_RS03920	COG0051	transcription antitermination factor activity, RNA binding
DOM22_RS03925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DOM22_RS03930	COG0088	Forms part of the polypeptide exit tunnel
DOM22_RS03935	COG0089	rRNA binding
DOM22_RS03940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DOM22_RS03945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DOM22_RS03950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DOM22_RS03955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DOM22_RS03960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DOM22_RS03965	COG0255	Belongs to the universal ribosomal protein uL29 family
DOM22_RS03970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DOM22_RS03975	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DOM22_RS03980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DOM22_RS03985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DOM22_RS03990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DOM22_RS03995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DOM22_RS04000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DOM22_RS04005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DOM22_RS04010	COG1841	ribosomal large subunit assembly
DOM22_RS04015	COG0200	Binds to the 23S rRNA
DOM22_RS04020	COG0201	protein transport
DOM22_RS04025	COG0563	adenylate kinase activity
DOM22_RS04030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DOM22_RS04035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DOM22_RS04040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DOM22_RS04045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DOM22_RS04050	COG0202	RNA polymerase activity
DOM22_RS04055	COG0203	ribosomal protein L17
DOM22_RS04060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOM22_RS04070	COG2205	protein histidine kinase activity
DOM22_RS04070	COG2198	Histidine kinase
DOM22_RS04070	COG0784	Response regulator, receiver
DOM22_RS04070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOM22_RS04085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DOM22_RS04120	COG1960	acyl-CoA dehydrogenase activity
DOM22_RS04140	COG0840	transmembrane signaling receptor activity
DOM22_RS04160	COG0366	Alpha amylase catalytic
DOM22_RS04165	COG2267	carboxylic ester hydrolase activity
DOM22_RS04175	COG0714	Associated with various cellular activities
DOM22_RS04180	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DOM22_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS04205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DOM22_RS04215	COG0427	acetyl-CoA hydrolase
DOM22_RS04235	COG2995	paraquat-inducible protein a
DOM22_RS04315	COG0438	transferase activity, transferring glycosyl groups
DOM22_RS04335	COG1902	pentaerythritol trinitrate reductase activity
DOM22_RS04355	COG1295	ribonuclease BN
DOM22_RS04365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOM22_RS04375	COG4589	Belongs to the CDS family
DOM22_RS04385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DOM22_RS04405	COG1879	ABC-type sugar transport system periplasmic component
DOM22_RS04410	COG0277	FAD linked oxidase domain protein
DOM22_RS04420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DOM22_RS04430	COG1368	sulfuric ester hydrolase activity
DOM22_RS04500	COG1027	Aspartate ammonia-lyase
DOM22_RS04530	COG1902	pentaerythritol trinitrate reductase activity
DOM22_RS04540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOM22_RS04595	COG0784	Response regulator, receiver
DOM22_RS04595	COG5002	protein histidine kinase activity
DOM22_RS04595	COG2198	Histidine kinase
DOM22_RS04600	COG2205	protein histidine kinase activity
DOM22_RS04600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOM22_RS04600	COG2198	Histidine kinase
DOM22_RS04600	COG0784	Response regulator, receiver
DOM22_RS04620	COG0724	RNA recognition motif
DOM22_RS04635	COG1271	oxidase subunit
DOM22_RS04645	COG2828	Protein conserved in bacteria
DOM22_RS04655	COG0741	lytic transglycosylase activity
DOM22_RS04665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DOM22_RS04670	COG0835	chemotaxis
DOM22_RS04735	COG0402	S-adenosylhomocysteine deaminase activity
DOM22_RS04740	COG0786	glutamate:sodium symporter activity
DOM22_RS04785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOM22_RS04785	COG2205	protein histidine kinase activity
DOM22_RS04785	COG2198	Histidine kinase
DOM22_RS04785	COG0784	Response regulator, receiver
DOM22_RS04790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DOM22_RS04795	COG2205	protein histidine kinase activity
DOM22_RS04795	COG0784	Response regulator, receiver
DOM22_RS04815	COG1335	isochorismatase
DOM22_RS04845	COG0840	transmembrane signaling receptor activity
DOM22_RS04850	COG4221	oxidoreductase activity
DOM22_RS04855	COG1335	isochorismatase
DOM22_RS04885	COG1408	metallophosphoesterase
DOM22_RS04915	COG0583	DNA-binding transcription factor activity
DOM22_RS04920	COG1064	alcohol dehydrogenase
DOM22_RS04925	COG0667	Aldo Keto reductase
DOM22_RS04935	COG1671	Belongs to the UPF0178 family
DOM22_RS04940	COG0475	glutathione-regulated potassium exporter activity
DOM22_RS04980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DOM22_RS04990	COG1192	Involved in chromosome partitioning
DOM22_RS05010	COG0589	response to stress
DOM22_RS05030	COG5002	protein histidine kinase activity
DOM22_RS05040	COG3604	Transcriptional regulator
DOM22_RS05060	COG1136	(ABC) transporter
DOM22_RS05075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DOM22_RS05100	COG3040	lipid binding
DOM22_RS05105	COG3040	lipid binding
DOM22_RS05125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DOM22_RS05130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DOM22_RS05165	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DOM22_RS05305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DOM22_RS05320	COG1489	DNA binding
DOM22_RS05365	COG1937	Protein conserved in bacteria
DOM22_RS05370	COG2217	Heavy metal translocating P-type atpase
DOM22_RS05375	COG2217	Heavy metal translocating P-type atpase
DOM22_RS05385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DOM22_RS05390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DOM22_RS05395	COG0431	NADPH-dependent FMN reductase
DOM22_RS05400	COG0798	PFAM Bile acid sodium symporter
DOM22_RS05420	COG0640	Transcriptional regulator
DOM22_RS05555	COG2217	Heavy metal translocating P-type atpase
DOM22_RS05560	COG0789	Transcriptional regulator
DOM22_RS05655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DOM22_RS05665	COG2088	sporulation resulting in formation of a cellular spore
DOM22_RS05675	COG0840	transmembrane signaling receptor activity
DOM22_RS05690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOM22_RS05700	COG0501	Belongs to the peptidase M48B family
DOM22_RS05705	COG0714	Associated with various cellular activities
DOM22_RS05725	COG2304	oxidoreductase activity
DOM22_RS05760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DOM22_RS05765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DOM22_RS05785	COG2832	Protein of unknown function (DUF454)
DOM22_RS05800	COG2843	Capsule synthesis protein
DOM22_RS05835	COG0747	negative chemotaxis
DOM22_RS05860	COG0861	Integral membrane protein TerC family
DOM22_RS05905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DOM22_RS05905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DOM22_RS05915	COG0835	chemotaxis
DOM22_RS05915	COG0784	Response regulator, receiver
DOM22_RS05925	COG0242	peptide deformylase activity
DOM22_RS05930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DOM22_RS05945	COG0494	nUDIX hydrolase
DOM22_RS05990	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DOM22_RS06000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOM22_RS06065	COG1181	Belongs to the D-alanine--D-alanine ligase family
DOM22_RS06095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOM22_RS06100	COG1695	Transcriptional regulator
DOM22_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS06130	COG0583	DNA-binding transcription factor activity
DOM22_RS06140	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOM22_RS06150	COG0588	phosphoglycerate mutase activity
DOM22_RS06155	COG0071	Belongs to the small heat shock protein (HSP20) family
DOM22_RS06170	COG0110	maltose O-acetyltransferase activity
DOM22_RS06175	COG1228	amidohydrolase
DOM22_RS06195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DOM22_RS06220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DOM22_RS06230	COG0601	transmembrane transport
DOM22_RS06235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOM22_RS06250	COG0012	GTP binding
DOM22_RS06255	COG0193	aminoacyl-tRNA hydrolase activity
DOM22_RS06260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DOM22_RS06265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DOM22_RS06275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DOM22_RS06280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DOM22_RS06285	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOM22_RS06300	COG0740	serine-type endopeptidase activity
DOM22_RS06305	COG0668	transmembrane transport
DOM22_RS06310	COG1968	undecaprenyl-diphosphatase activity
DOM22_RS06325	COG1024	Enoyl-CoA hydratase
DOM22_RS06340	COG2917	probably involved in intracellular septation
DOM22_RS06345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DOM22_RS06365	COG2259	Doxx family
DOM22_RS06395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DOM22_RS06435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOM22_RS06530	COG2814	Major facilitator Superfamily
DOM22_RS06535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DOM22_RS06550	COG5002	protein histidine kinase activity
DOM22_RS06580	COG4269	membrane
DOM22_RS06590	COG3214	Protein conserved in bacteria
DOM22_RS06680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOM22_RS06685	COG0519	Catalyzes the synthesis of GMP from XMP
DOM22_RS06735	COG0443	Heat shock 70 kDa protein
DOM22_RS06740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOM22_RS06750	COG2897	thiosulfate sulfurtransferase activity
DOM22_RS06765	COG0730	response to heat
DOM22_RS06770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DOM22_RS06780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOM22_RS06830	COG0577	efflux transmembrane transporter activity
DOM22_RS06830	COG1136	(ABC) transporter
DOM22_RS06845	COG3012	SEC-C Motif Domain Protein
DOM22_RS06850	COG4221	oxidoreductase activity
DOM22_RS06870	COG0210	DNA helicase
DOM22_RS06875	COG0564	pseudouridine synthase activity
DOM22_RS06910	COG0488	(ABC) transporter
DOM22_RS06915	COG2205	protein histidine kinase activity
DOM22_RS06915	COG0784	Response regulator, receiver
DOM22_RS06930	COG0024	Methionine aminopeptidase
DOM22_RS06935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DOM22_RS06965	COG3237	CsbD-like
DOM22_RS06990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DOM22_RS06995	COG0745	RESPONSE REGULATOR receiver
DOM22_RS07020	COG2850	peptidyl-arginine hydroxylation
DOM22_RS07030	COG0386	Belongs to the glutathione peroxidase family
DOM22_RS07055	COG5002	protein histidine kinase activity
DOM22_RS07055	COG2198	Histidine kinase
DOM22_RS07055	COG0784	Response regulator, receiver
DOM22_RS07075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOM22_RS07075	COG0574	Belongs to the PEP-utilizing enzyme family
DOM22_RS07085	COG0039	L-malate dehydrogenase activity
DOM22_RS07105	COG2195	Cleaves the N-terminal amino acid of tripeptides
DOM22_RS07115	COG1404	Belongs to the peptidase S8 family
DOM22_RS07145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOM22_RS07165	COG0840	transmembrane signaling receptor activity
DOM22_RS07210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOM22_RS07220	COG0840	transmembrane signaling receptor activity
DOM22_RS07225	COG0826	peptidase U32
DOM22_RS07235	COG0840	transmembrane signaling receptor activity
DOM22_RS07240	COG0513	Belongs to the DEAD box helicase family
DOM22_RS07250	COG1335	isochorismatase
DOM22_RS07260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOM22_RS07275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOM22_RS07305	COG3034	peptidoglycan biosynthetic process
DOM22_RS07350	COG0281	malic enzyme
DOM22_RS07370	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DOM22_RS07380	COG0513	Belongs to the DEAD box helicase family
DOM22_RS07395	COG0095	Lipoate-protein ligase
DOM22_RS07465	COG0513	Belongs to the DEAD box helicase family
DOM22_RS07470	COG0488	(ABC) transporter
DOM22_RS07485	COG2270	Major facilitator Superfamily
DOM22_RS07495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DOM22_RS07525	COG1418	mRNA catabolic process
DOM22_RS07545	COG1404	Belongs to the peptidase S8 family
DOM22_RS07555	COG1956	GAF domain-containing protein
DOM22_RS07570	COG2326	polyphosphate kinase activity
DOM22_RS07575	COG1764	response to oxidative stress
DOM22_RS07580	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DOM22_RS07585	COG5002	protein histidine kinase activity
DOM22_RS07600	COG5002	protein histidine kinase activity
DOM22_RS07605	COG0784	Response regulator, receiver
DOM22_RS07610	COG2198	Histidine kinase
DOM22_RS07610	COG2205	protein histidine kinase activity
DOM22_RS07610	COG0784	Response regulator, receiver
DOM22_RS07610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOM22_RS07615	COG0784	Response regulator, receiver
DOM22_RS07615	COG2198	Histidine kinase
DOM22_RS07615	COG5002	protein histidine kinase activity
DOM22_RS07625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DOM22_RS07640	COG0596	Alpha beta hydrolase
DOM22_RS07670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DOM22_RS07675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DOM22_RS07680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DOM22_RS07690	COG1466	dna polymerase III delta subunit
DOM22_RS07710	COG0268	Binds directly to 16S ribosomal RNA
DOM22_RS07715	COG0728	peptidoglycan biosynthetic process
DOM22_RS07720	COG0840	transmembrane signaling receptor activity
DOM22_RS07725	COG0840	transmembrane signaling receptor activity
DOM22_RS07730	COG0840	transmembrane signaling receptor activity
DOM22_RS07775	COG0811	peptide transport
DOM22_RS07795	COG3956	TIGRFAM MazG family protein
DOM22_RS07805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DOM22_RS07820	COG1136	(ABC) transporter
DOM22_RS07825	COG5640	endopeptidase activity
DOM22_RS07840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOM22_RS07855	COG1663	tetraacyldisaccharide 4'-kinase activity
DOM22_RS07860	COG1560	Kdo2-lipid A biosynthetic process
DOM22_RS07885	COG0859	PFAM glycosyl transferase family 9
DOM22_RS07890	COG2204	response regulator
DOM22_RS07895	COG2205	protein histidine kinase activity
DOM22_RS07900	COG0196	riboflavin kinase activity
DOM22_RS07910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DOM22_RS07920	COG1459	type II secretion system
DOM22_RS07925	COG3852	Histidine kinase
DOM22_RS07930	COG2204	response regulator
DOM22_RS07945	COG0412	Dienelactone hydrolase
DOM22_RS08000	COG0564	pseudouridine synthase activity
DOM22_RS08085	COG0779	Required for maturation of 30S ribosomal subunits
DOM22_RS08090	COG0195	Participates in both transcription termination and antitermination
DOM22_RS08095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DOM22_RS08100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DOM22_RS08105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DOM22_RS08110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DOM22_RS08115	COG1185	polyribonucleotide nucleotidyltransferase activity
DOM22_RS08120	COG0612	Peptidase, M16
DOM22_RS08125	COG0756	dUTP diphosphatase activity
DOM22_RS08155	COG1216	Glycosyl transferase, family 2
DOM22_RS08170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DOM22_RS08175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DOM22_RS08180	COG1561	YicC-like family, N-terminal region
DOM22_RS08185	COG0194	GDP metabolic process
DOM22_RS08190	COG1758	RNA polymerase activity
DOM22_RS08200	COG3852	Histidine kinase
DOM22_RS08260	COG2165	general secretion pathway protein
DOM22_RS08265	COG1459	type II secretion system
DOM22_RS08270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DOM22_RS08275	COG1450	Type ii and iii secretion system protein
DOM22_RS08305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DOM22_RS08310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DOM22_RS08320	COG0151	Belongs to the GarS family
DOM22_RS08325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DOM22_RS08330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DOM22_RS08335	COG0047	phosphoribosylformylglycinamidine synthase activity
DOM22_RS08340	COG0138	bifunctional purine biosynthesis protein purh
DOM22_RS08360	COG4191	Histidine kinase
DOM22_RS08380	COG2096	Adenosyltransferase
DOM22_RS08390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DOM22_RS08390	COG1333	cytochrome c biogenesis protein
DOM22_RS08395	COG1333	cytochrome c biogenesis protein
DOM22_RS08395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DOM22_RS08405	COG0437	4 iron, 4 sulfur cluster binding
DOM22_RS08445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DOM22_RS08450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DOM22_RS08460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DOM22_RS08485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DOM22_RS08485	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DOM22_RS08500	COG0584	glycerophosphoryl diester phosphodiesterase
DOM22_RS08505	COG0427	acetyl-CoA hydrolase
DOM22_RS08525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DOM22_RS08530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DOM22_RS08535	COG1304	FMN binding
DOM22_RS08625	COG0840	transmembrane signaling receptor activity
DOM22_RS08630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOM22_RS08630	COG0357	Ribosomal RNA small subunit methyltransferase G
DOM22_RS08635	COG0357	Ribosomal RNA small subunit methyltransferase G
DOM22_RS08645	COG2031	fatty acid transporter
DOM22_RS08655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DOM22_RS08660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOM22_RS08660	COG0072	phenylalanine-tRNA ligase activity
DOM22_RS08665	COG0776	regulation of translation
DOM22_RS08700	COG0784	Response regulator, receiver
DOM22_RS08700	COG2205	protein histidine kinase activity
DOM22_RS08705	COG0784	Response regulator, receiver
DOM22_RS08705	COG2205	protein histidine kinase activity
DOM22_RS08740	COG0456	acetyltransferase
DOM22_RS08745	COG1733	regulation of RNA biosynthetic process
DOM22_RS08765	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DOM22_RS08785	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DOM22_RS08840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DOM22_RS08845	COG0343	queuine tRNA-ribosyltransferase activity
DOM22_RS08850	COG1862	Preprotein translocase
DOM22_RS08855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DOM22_RS08860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DOM22_RS08870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DOM22_RS08890	COG2217	Heavy metal translocating P-type atpase
DOM22_RS08920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DOM22_RS08925	COG1612	heme a metabolic process
DOM22_RS08925	COG0109	protoheme IX farnesyltransferase activity
DOM22_RS08975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOM22_RS08985	COG0415	Belongs to the DNA photolyase family
DOM22_RS08990	COG1090	epimerase
DOM22_RS08995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DOM22_RS09005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DOM22_RS09025	COG0735	belongs to the Fur family
DOM22_RS09045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DOM22_RS09050	COG0573	inorganic phosphate transmembrane transporter activity
DOM22_RS09055	COG0581	inorganic phosphate transmembrane transporter activity
DOM22_RS09060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DOM22_RS09075	COG1215	transferase activity, transferring glycosyl groups
DOM22_RS09095	COG0463	Glycosyl transferase, family 2
DOM22_RS09100	COG2755	lipolytic protein G-D-S-L family
DOM22_RS09100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DOM22_RS09150	COG0277	FAD linked oxidase domain protein
DOM22_RS09155	COG0546	phosphoglycolate phosphatase activity
DOM22_RS09155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DOM22_RS09215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOM22_RS09270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DOM22_RS09295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DOM22_RS09300	COG3021	interspecies interaction between organisms
DOM22_RS09330	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DOM22_RS09340	COG3932	Exopolysaccharide synthesis, ExoD
DOM22_RS09350	COG1720	tRNA m6t6A37 methyltransferase activity
DOM22_RS09360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOM22_RS09360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOM22_RS09365	COG0288	reversible hydration of carbon dioxide
DOM22_RS09375	COG1077	Cell shape determining protein MreB Mrl
DOM22_RS09505	COG2076	Multidrug Resistance protein
DOM22_RS09510	COG0431	NADPH-dependent FMN reductase
DOM22_RS09515	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DOM22_RS09520	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DOM22_RS09525	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DOM22_RS09530	COG2205	protein histidine kinase activity
DOM22_RS09535	COG0745	RESPONSE REGULATOR receiver
DOM22_RS09565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOM22_RS09570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOM22_RS09580	COG4591	ABC-type transport system involved in lipoprotein release permease component
DOM22_RS09585	COG2171	N-acyltransferase activity
DOM22_RS09595	COG0019	diaminopimelate decarboxylase activity
DOM22_RS09600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DOM22_RS09605	COG0516	GMP reductase activity
DOM22_RS09605	COG0517	IMP dehydrogenase activity
DOM22_RS09615	COG0702	epimerase
DOM22_RS09625	COG0628	permease
DOM22_RS09655	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS09660	COG1054	Belongs to the UPF0176 family
DOM22_RS09665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DOM22_RS09670	COG1131	(ABC) transporter
DOM22_RS09675	COG0842	Transport permease protein
DOM22_RS09680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DOM22_RS09685	COG0228	four-way junction DNA binding
DOM22_RS09695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DOM22_RS09700	COG0336	Belongs to the RNA methyltransferase TrmD family
DOM22_RS09705	COG4752	Belongs to the RNA methyltransferase TrmD family
DOM22_RS09705	COG0336	Belongs to the RNA methyltransferase TrmD family
DOM22_RS09710	COG0335	large ribosomal subunit rRNA binding
DOM22_RS09715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DOM22_RS09725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DOM22_RS09760	COG0776	regulation of translation
DOM22_RS09790	COG2066	Belongs to the glutaminase family
DOM22_RS09790	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DOM22_RS09800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DOM22_RS09805	COG0183	Belongs to the thiolase family
DOM22_RS09835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOM22_RS09845	COG4651	solute:proton antiporter activity
DOM22_RS09845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DOM22_RS09850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DOM22_RS09855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DOM22_RS09860	COG0517	IMP dehydrogenase activity
DOM22_RS09860	COG0516	GMP reductase activity
DOM22_RS09865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DOM22_RS09865	COG0519	Catalyzes the synthesis of GMP from XMP
DOM22_RS09915	COG0017	Asparaginyl-tRNA synthetase
DOM22_RS09935	COG0625	glutathione transferase activity
DOM22_RS09940	COG0037	tRNA processing
DOM22_RS09955	COG3034	peptidoglycan biosynthetic process
DOM22_RS09970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOM22_RS09980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOM22_RS10000	COG1837	Belongs to the UPF0109 family
DOM22_RS10055	COG0018	arginyl-trna synthetase
DOM22_RS10065	COG0582	viral genome integration into host DNA
DOM22_RS10080	COG1116	anion transmembrane transporter activity
DOM22_RS10085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOM22_RS10100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DOM22_RS10105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOM22_RS10110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DOM22_RS10115	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS10120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DOM22_RS10125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DOM22_RS10130	COG0698	ribose 5-phosphate isomerase
DOM22_RS10135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DOM22_RS10160	COG3158	transport of potassium into the cell
DOM22_RS10165	COG0431	NADPH-dependent FMN reductase
DOM22_RS10180	COG0811	peptide transport
DOM22_RS10185	COG0848	biopolymer transport protein
DOM22_RS10240	COG1242	4 iron, 4 sulfur cluster binding
DOM22_RS10245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOM22_RS10245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DOM22_RS10250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOM22_RS10275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DOM22_RS10280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DOM22_RS10285	COG1994	Peptidase M50
DOM22_RS10290	COG1960	acyl-CoA dehydrogenase activity
DOM22_RS10300	COG5001	Diguanylate cyclase
DOM22_RS10300	COG1716	ATPase activity
DOM22_RS10320	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS10330	COG1187	pseudouridine synthase activity
DOM22_RS10360	COG0217	transcriptional regulatory protein
DOM22_RS10380	COG2166	iron-sulfur cluster assembly
DOM22_RS10405	COG2814	Major facilitator Superfamily
DOM22_RS10420	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DOM22_RS10425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DOM22_RS10430	COG0840	transmembrane signaling receptor activity
DOM22_RS10435	COG0745	RESPONSE REGULATOR receiver
DOM22_RS10450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DOM22_RS10455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DOM22_RS10465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DOM22_RS10475	COG0386	Belongs to the glutathione peroxidase family
DOM22_RS10485	COG0733	neurotransmitter:sodium symporter activity
DOM22_RS10490	COG1160	GTP binding
DOM22_RS10500	COG0571	ribonuclease III activity
DOM22_RS10505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOM22_RS10510	COG0482	sulfurtransferase activity
DOM22_RS10515	COG1104	cysteine desulfurase activity
DOM22_RS10525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOM22_RS10530	COG0802	atpase or kinase
DOM22_RS10535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DOM22_RS10540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOM22_RS10550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DOM22_RS10555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DOM22_RS10560	COG0037	tRNA processing
DOM22_RS10565	COG1012	belongs to the aldehyde dehydrogenase family
DOM22_RS10585	COG0745	RESPONSE REGULATOR receiver
DOM22_RS10605	COG1494	fructose-1,6-bisphosphatase
DOM22_RS10610	COG0824	Thioesterase
DOM22_RS10615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DOM22_RS10630	COG0471	metal ion transport
DOM22_RS10665	COG0726	polysaccharide deacetylase
DOM22_RS10665	COG1649	PFAM Uncharacterised BCR, COG1649
DOM22_RS10670	COG1215	transferase activity, transferring glycosyl groups
DOM22_RS10890	COG1999	signal sequence binding
DOM22_RS10900	COG0842	Transport permease protein
DOM22_RS10905	COG1129	ABC transporter
DOM22_RS10905	COG0842	Transport permease protein
DOM22_RS10910	COG1131	(ABC) transporter
DOM22_RS10915	COG1131	(ABC) transporter
DOM22_RS10920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOM22_RS10930	COG0840	transmembrane signaling receptor activity
DOM22_RS10935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DOM22_RS10975	COG0720	synthase
DOM22_RS10990	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DOM22_RS10995	COG0312	modulator of DNA gyrase
DOM22_RS11030	COG1703	isobutyryl-CoA mutase activity
DOM22_RS11030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOM22_RS11030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOM22_RS11035	COG1024	Enoyl-CoA hydratase
DOM22_RS11040	COG1250	3-hydroxyacyl-CoA dehydrogenase
DOM22_RS11060	COG2323	membrane
DOM22_RS11070	COG1793	dna ligase
DOM22_RS11075	COG1201	RNA secondary structure unwinding
DOM22_RS11095	COG1404	Belongs to the peptidase S8 family
DOM22_RS11105	COG2198	Histidine kinase
DOM22_RS11105	COG5002	protein histidine kinase activity
DOM22_RS11105	COG0784	Response regulator, receiver
DOM22_RS11155	COG3104	oligopeptide transport
DOM22_RS11160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DOM22_RS11165	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DOM22_RS11170	COG3387	PFAM Glycoside hydrolase 15-related
DOM22_RS11180	COG0642	Histidine kinase
DOM22_RS11205	COG0280	phosphate acetyltransferase
DOM22_RS11205	COG0281	malic enzyme
DOM22_RS11215	COG3459	Glycosyltransferase 36 associated
DOM22_RS11220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DOM22_RS11240	COG1607	acyl-coa hydrolase
DOM22_RS11245	COG2197	response regulator
DOM22_RS11260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DOM22_RS11275	COG0617	tRNA 3'-terminal CCA addition
DOM22_RS11295	COG0038	chloride channel
DOM22_RS11300	COG2900	Belongs to the SlyX family
DOM22_RS11330	COG3483	tryptophan 2,3-dioxygenase activity
DOM22_RS11335	COG0326	Molecular chaperone. Has ATPase activity
DOM22_RS11345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DOM22_RS11355	COG0318	PFAM AMP-dependent synthetase and ligase
DOM22_RS11370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DOM22_RS11455	COG0477	Major facilitator Superfamily
DOM22_RS11460	COG2176	DNA-directed DNA polymerase activity
DOM22_RS11470	COG0443	Heat shock 70 kDa protein
DOM22_RS11490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DOM22_RS11490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DOM22_RS11515	COG0038	chloride channel
DOM22_RS11555	COG0730	response to heat
DOM22_RS11565	COG2814	Major facilitator Superfamily
DOM22_RS11580	COG1418	mRNA catabolic process
DOM22_RS11590	COG1253	flavin adenine dinucleotide binding
DOM22_RS11625	COG1960	acyl-CoA dehydrogenase activity
DOM22_RS11635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DOM22_RS11645	COG0840	transmembrane signaling receptor activity
DOM22_RS11675	COG0625	glutathione transferase activity
DOM22_RS11710	COG0583	DNA-binding transcription factor activity
DOM22_RS11740	COG0616	signal peptide processing
DOM22_RS11745	COG0444	Belongs to the ABC transporter superfamily
DOM22_RS11750	COG4608	Belongs to the ABC transporter superfamily
DOM22_RS11755	COG4166	transmembrane transport
DOM22_RS11760	COG0601	transmembrane transport
DOM22_RS11765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOM22_RS11775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOM22_RS11780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOM22_RS11785	COG0584	glycerophosphoryl diester phosphodiesterase
DOM22_RS11795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOM22_RS11810	COG0189	ligase activity
DOM22_RS11815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOM22_RS11835	COG1720	tRNA m6t6A37 methyltransferase activity
DOM22_RS11840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DOM22_RS11850	COG2814	Major facilitator Superfamily
DOM22_RS11865	COG0288	reversible hydration of carbon dioxide
DOM22_RS11880	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DOM22_RS11885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DOM22_RS11890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DOM22_RS11900	COG0387	Pfam Sodium calcium exchanger
DOM22_RS11905	COG1012	belongs to the aldehyde dehydrogenase family
DOM22_RS11925	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS12010	COG0475	glutathione-regulated potassium exporter activity
DOM22_RS12015	COG1404	Belongs to the peptidase S8 family
DOM22_RS12040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOM22_RS12055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DOM22_RS12075	COG3278	Belongs to the heme-copper respiratory oxidase family
DOM22_RS12085	COG2010	Cytochrome c
DOM22_RS12090	COG0348	domain, Protein
DOM22_RS12115	COG0328	RNA-DNA hybrid ribonuclease activity
DOM22_RS12120	COG2814	Major facilitator Superfamily
DOM22_RS12135	COG2205	protein histidine kinase activity
DOM22_RS12135	COG0784	Response regulator, receiver
DOM22_RS12145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DOM22_RS12165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOM22_RS12170	COG0477	Major facilitator Superfamily
DOM22_RS12195	COG4974	Belongs to the 'phage' integrase family
DOM22_RS12215	COG2385	sporulation resulting in formation of a cellular spore
DOM22_RS12245	COG0728	peptidoglycan biosynthetic process
DOM22_RS12250	COG0322	excinuclease ABC activity
DOM22_RS12255	COG0556	nucleotide-excision repair
DOM22_RS12270	COG0215	cysteine-tRNA ligase activity
DOM22_RS12275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DOM22_RS12285	COG1404	Belongs to the peptidase S8 family
DOM22_RS12320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DOM22_RS12340	COG0784	Response regulator, receiver
DOM22_RS12340	COG2205	protein histidine kinase activity
DOM22_RS12355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DOM22_RS12360	COG1830	Aldolase
DOM22_RS12370	COG0534	Mate efflux family protein
DOM22_RS12415	COG0633	Ferredoxin
DOM22_RS12415	COG3217	Mosc domain protein beta barrel domain protein
DOM22_RS12430	COG2951	lytic endotransglycosylase activity
DOM22_RS12435	COG0477	Major facilitator Superfamily
DOM22_RS12455	COG4106	trans-aconitate 2-methyltransferase activity
DOM22_RS12460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DOM22_RS12465	COG0084	hydrolase, TatD family'
DOM22_RS12480	COG0586	Pfam SNARE associated Golgi protein
DOM22_RS12485	COG0564	pseudouridine synthase activity
DOM22_RS12485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DOM22_RS12505	COG0116	Belongs to the methyltransferase superfamily
DOM22_RS12585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOM22_RS12600	COG2201	protein-glutamate methylesterase activity
DOM22_RS12640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DOM22_RS12675	COG0784	Response regulator, receiver
DOM22_RS12675	COG3437	response regulator, receiver
DOM22_RS12695	COG2871	sodium ion transport
DOM22_RS12700	COG0697	spore germination
DOM22_RS12710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DOM22_RS12725	COG0681	Belongs to the peptidase S26 family
DOM22_RS12745	COG1469	GTP cyclohydrolase I activity
DOM22_RS12750	COG0424	maF-like protein
DOM22_RS12755	COG0295	cytidine deaminase activity
DOM22_RS12840	COG1792	Involved in formation and maintenance of cell shape
DOM22_RS12850	COG0768	penicillin binding
DOM22_RS12855	COG0772	Belongs to the SEDS family
DOM22_RS12885	COG0789	Transcriptional regulator
DOM22_RS12890	COG0741	lytic transglycosylase activity
DOM22_RS12920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DOM22_RS12920	COG0758	DNA mediated transformation
DOM22_RS12970	COG4264	IucA IucC family
DOM22_RS13000	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DOM22_RS13010	COG2255	four-way junction helicase activity
DOM22_RS13015	COG0632	four-way junction helicase activity
DOM22_RS13020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DOM22_RS13030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DOM22_RS13065	COG2079	MmgE PrpD family protein
DOM22_RS13070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DOM22_RS13090	COG1522	sequence-specific DNA binding
DOM22_RS13125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DOM22_RS13130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DOM22_RS13240	COG1289	transmembrane transporter activity
DOM22_RS13250	COG0308	aminopeptidase N
DOM22_RS13265	COG0302	gtp cyclohydrolase
DOM22_RS13340	COG1132	(ABC) transporter
DOM22_RS13345	COG1132	(ABC) transporter
DOM22_RS13350	COG2239	Acts as a magnesium transporter
DOM22_RS13400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DOM22_RS13410	COG2967	ApaG domain
DOM22_RS13480	COG0259	pyridoxamine-phosphate oxidase activity
DOM22_RS13485	COG0545	Peptidyl-prolyl cis-trans isomerase
DOM22_RS13500	COG0745	RESPONSE REGULATOR receiver
DOM22_RS13505	COG2205	protein histidine kinase activity
DOM22_RS13535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOM22_RS13540	COG2885	chlorophyll binding
DOM22_RS13550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DOM22_RS13560	COG0783	Belongs to the Dps family
DOM22_RS13580	COG3850	Histidine kinase
DOM22_RS13580	COG5002	protein histidine kinase activity
DOM22_RS13650	COG0840	transmembrane signaling receptor activity
DOM22_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
DOM22_RS13680	COG0572	uridine kinase
DOM22_RS13685	COG0531	amino acid
DOM22_RS13700	COG2824	Alkylphosphonate utilization operon protein PhnA
DOM22_RS13730	COG0484	heat shock protein binding
DOM22_RS13740	COG4968	Prepilin-type N-terminal cleavage methylation domain
DOM22_RS13745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DOM22_RS13790	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DOM22_RS13865	COG0473	3-isopropylmalate dehydrogenase activity
DOM22_RS13880	COG2205	protein histidine kinase activity
DOM22_RS13885	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DOM22_RS13895	COG0179	Fumarylacetoacetate (FAA) hydrolase
DOM22_RS13900	COG1012	belongs to the aldehyde dehydrogenase family
DOM22_RS13930	COG1047	Peptidyl-prolyl cis-trans
DOM22_RS13935	COG0724	RNA recognition motif
DOM22_RS13990	COG5640	endopeptidase activity
DOM22_RS14000	COG5640	endopeptidase activity
DOM22_RS14015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DOM22_RS14020	COG1741	Belongs to the pirin family
DOM22_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS14080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DOM22_RS14085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DOM22_RS14110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DOM22_RS14115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DOM22_RS14140	COG2986	histidine ammonia-lyase
DOM22_RS14150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DOM22_RS14155	COG1704	LemA family
DOM22_RS14160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOM22_RS14160	COG0116	Belongs to the methyltransferase superfamily
DOM22_RS14170	COG0668	transmembrane transport
DOM22_RS14180	COG5599	Phosphatase
DOM22_RS14190	COG1960	acyl-CoA dehydrogenase activity
DOM22_RS14195	COG1058	Belongs to the CinA family
DOM22_RS14195	COG1546	Belongs to the CinA family
DOM22_RS14205	COG2814	Major facilitator Superfamily
DOM22_RS14210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DOM22_RS14210	COG0539	negative regulation of cytoplasmic translation
DOM22_RS14215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOM22_RS14225	COG1104	cysteine desulfurase activity
DOM22_RS14245	COG0596	Alpha beta hydrolase
DOM22_RS14255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DOM22_RS14260	COG1418	mRNA catabolic process
DOM22_RS14265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DOM22_RS14270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DOM22_RS14300	COG0702	epimerase
DOM22_RS14305	COG0552	protein localization to endoplasmic reticulum
DOM22_RS14310	COG0840	transmembrane signaling receptor activity
DOM22_RS14355	COG1132	(ABC) transporter
DOM22_RS14380	COG0583	DNA-binding transcription factor activity
DOM22_RS14395	COG0583	DNA-binding transcription factor activity
DOM22_RS14405	COG1196	nuclear chromosome segregation
DOM22_RS14435	COG0574	Belongs to the PEP-utilizing enzyme family
DOM22_RS14435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOM22_RS14460	COG0423	glycine-tRNA ligase activity
DOM22_RS14480	COG0489	protein tyrosine kinase activity
DOM22_RS14515	COG0791	NLP P60 protein
DOM22_RS14515	COG1388	LysM domain
DOM22_RS14570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DOM22_RS14580	COG4181	ATPase activity
DOM22_RS14595	COG0124	histidyl-tRNA synthetase
DOM22_RS14605	COG1404	Belongs to the peptidase S8 family
DOM22_RS14620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DOM22_RS14645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOM22_RS14645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DOM22_RS14655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DOM22_RS14660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOM22_RS14675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DOM22_RS14690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOM22_RS14700	COG0840	transmembrane signaling receptor activity
DOM22_RS14705	COG0583	DNA-binding transcription factor activity
DOM22_RS14720	COG0612	Peptidase, M16
DOM22_RS14725	COG1580	Controls the rotational direction of flagella during chemotaxis
DOM22_RS14760	COG0616	signal peptide processing
DOM22_RS14805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DOM22_RS14810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DOM22_RS14825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOM22_RS14840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DOM22_RS14855	COG0149	triose-phosphate isomerase activity
DOM22_RS14860	COG0126	phosphoglycerate kinase activity
DOM22_RS14875	COG1272	protein, Hemolysin III
DOM22_RS14890	COG0084	hydrolase, TatD family'
DOM22_RS14895	COG0470	DNA polymerase III
DOM22_RS14900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DOM22_RS14955	COG0598	Magnesium transport protein CorA
DOM22_RS14965	COG4106	trans-aconitate 2-methyltransferase activity
DOM22_RS15015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DOM22_RS15015	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DOM22_RS15030	COG5002	protein histidine kinase activity
DOM22_RS15035	COG0745	RESPONSE REGULATOR receiver
DOM22_RS15040	COG0704	Plays a role in the regulation of phosphate uptake
DOM22_RS15050	COG0248	Ppx GppA phosphatase
DOM22_RS15065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DOM22_RS15070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DOM22_RS15090	COG3384	dioxygenase
DOM22_RS15120	COG0488	(ABC) transporter
DOM22_RS15125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DOM22_RS15135	COG0514	ATP-dependent DNA helicase (RecQ)
DOM22_RS15140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DOM22_RS15200	COG1253	flavin adenine dinucleotide binding
DOM22_RS15205	COG1324	tolerance protein
DOM22_RS15210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DOM22_RS15300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DOM22_RS15300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DOM22_RS15315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DOM22_RS15330	COG0312	modulator of DNA gyrase
DOM22_RS15335	COG0312	modulator of DNA gyrase
DOM22_RS15355	COG0693	protein deglycase activity
DOM22_RS15375	COG2183	response to ionizing radiation
DOM22_RS15380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DOM22_RS15390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DOM22_RS15400	COG0840	transmembrane signaling receptor activity
DOM22_RS15420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOM22_RS15420	COG0116	Belongs to the methyltransferase superfamily
DOM22_RS15435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DOM22_RS15445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DOM22_RS15450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DOM22_RS15455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DOM22_RS15490	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOM22_RS15515	COG1090	epimerase
DOM22_RS15555	COG1538	Outer membrane efflux protein
DOM22_RS15560	COG0252	asparaginase activity
DOM22_RS15570	COG1752	Esterase of the alpha-beta hydrolase superfamily
DOM22_RS15605	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DOM22_RS15610	COG2267	carboxylic ester hydrolase activity
DOM22_RS15615	COG0583	DNA-binding transcription factor activity
DOM22_RS15650	COG0745	RESPONSE REGULATOR receiver
DOM22_RS15655	COG0784	Response regulator, receiver
DOM22_RS15655	COG2205	protein histidine kinase activity
DOM22_RS15655	COG5002	protein histidine kinase activity
DOM22_RS15680	COG2154	pterin-4-alpha-carbinolamine dehydratase
DOM22_RS15690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOM22_RS15705	COG0559	Belongs to the binding-protein-dependent transport system permease family
DOM22_RS15725	COG2885	chlorophyll binding
DOM22_RS15785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DOM22_RS15835	COG1131	(ABC) transporter
DOM22_RS15845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DOM22_RS15865	COG0681	Belongs to the peptidase S26 family
DOM22_RS15875	COG0681	Belongs to the peptidase S26 family
DOM22_RS15880	COG0681	Belongs to the peptidase S26 family
DOM22_RS15885	COG0481	GTPase activity
DOM22_RS15890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DOM22_RS15905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DOM22_RS15910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOM22_RS15940	COG0811	peptide transport
DOM22_RS15980	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DOM22_RS15990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DOM22_RS15990	COG0517	IMP dehydrogenase activity
DOM22_RS15995	COG0504	CTP synthase activity
DOM22_RS16000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DOM22_RS16005	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DOM22_RS16010	COG2204	response regulator
DOM22_RS16025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOM22_RS16025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOM22_RS16045	COG0148	phosphopyruvate hydratase activity
DOM22_RS16075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DOM22_RS16075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DOM22_RS16155	COG4254	PFAM FecR protein
DOM22_RS16220	COG1489	DNA binding
DOM22_RS16240	COG0183	Belongs to the thiolase family
DOM22_RS16270	COG2030	dehydratase
DOM22_RS16275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DOM22_RS16290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOM22_RS16380	COG1175	transmembrane transport
DOM22_RS16385	COG3833	ABC-type maltose transport systems, permease component
DOM22_RS16390	COG3842	ATPase activity
DOM22_RS16400	COG1940	carbohydrate kinase activity
DOM22_RS16410	COG0166	Belongs to the GPI family
DOM22_RS16425	COG1846	Transcriptional regulator
DOM22_RS16430	COG1764	response to oxidative stress
DOM22_RS16440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DOM22_RS16460	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DOM22_RS16460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DOM22_RS16485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DOM22_RS16490	COG0167	dihydroorotate dehydrogenase activity
DOM22_RS16495	COG0494	nUDIX hydrolase
DOM22_RS16510	COG0776	regulation of translation
DOM22_RS16515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DOM22_RS16540	COG3093	addiction module antidote protein HigA
DOM22_RS16550	COG0312	modulator of DNA gyrase
DOM22_RS16580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DOM22_RS16580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DOM22_RS16600	COG2264	protein methyltransferase activity
DOM22_RS16610	COG0509	glycine decarboxylation via glycine cleavage system
DOM22_RS16615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DOM22_RS16655	COG5002	protein histidine kinase activity
DOM22_RS16675	COG0745	RESPONSE REGULATOR receiver
DOM22_RS16690	COG1490	D-aminoacyl-tRNA deacylase activity
DOM22_RS16730	COG3876	Protein conserved in bacteria
DOM22_RS16760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOM22_RS16790	COG2843	Capsule synthesis protein
DOM22_RS16810	COG0513	Belongs to the DEAD box helicase family
DOM22_RS16815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DOM22_RS16830	COG1272	protein, Hemolysin III
DOM22_RS16840	COG0494	nUDIX hydrolase
DOM22_RS16855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DOM22_RS16855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DOM22_RS16860	COG0024	Methionine aminopeptidase
DOM22_RS16880	COG2814	Major facilitator Superfamily
DOM22_RS16895	COG1846	Transcriptional regulator
DOM22_RS16910	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DOM22_RS16940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DOM22_RS16945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DOM22_RS16950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DOM22_RS16965	COG2885	chlorophyll binding
DOM22_RS17020	COG2204	response regulator
DOM22_RS17025	COG4964	Belongs to the GSP D family
DOM22_RS17050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DOM22_RS17060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DOM22_RS17075	COG1191	sigma factor activity
DOM22_RS17095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOM22_RS17100	COG1684	flagellar biosynthetic protein fliR
DOM22_RS17105	COG1987	bacterial-type flagellum assembly
DOM22_RS17110	COG1338	Plays a role in the flagellum-specific transport system
DOM22_RS17120	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DOM22_RS17120	COG1776	CheC inhibitor of MCP methylation
DOM22_RS17150	COG0483	inositol monophosphate 1-phosphatase activity
DOM22_RS17175	COG0210	DNA helicase
DOM22_RS17225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DOM22_RS17230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOM22_RS17245	COG2205	protein histidine kinase activity
DOM22_RS17260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DOM22_RS17275	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DOM22_RS17280	COG5000	phosphorelay sensor kinase activity
DOM22_RS17290	COG0803	Belongs to the bacterial solute-binding protein 9 family
DOM22_RS17295	COG1121	(ABC) transporter
DOM22_RS17310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DOM22_RS17320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DOM22_RS17330	COG0205	6-phosphofructokinase activity
DOM22_RS17380	COG0745	RESPONSE REGULATOR receiver
DOM22_RS17395	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DOM22_RS17415	COG1157	protein secretion by the type III secretion system
DOM22_RS17425	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DOM22_RS17430	COG1766	The M ring may be actively involved in energy transduction
DOM22_RS17435	COG1677	Flagellar hook-basal body complex protein FliE
DOM22_RS17445	COG1815	bacterial-type flagellum-dependent cell motility
DOM22_RS17450	COG2204	response regulator
DOM22_RS17465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOM22_RS17470	COG1127	ABC transporter
DOM22_RS17495	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DOM22_RS17515	COG1435	thymidine kinase activity
DOM22_RS17520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DOM22_RS17530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DOM22_RS17535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DOM22_RS17560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOM22_RS17600	COG0113	porphobilinogen synthase activity
DOM22_RS17610	COG0181	hydroxymethylbilane synthase activity
DOM22_RS17615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DOM22_RS17625	COG0745	RESPONSE REGULATOR receiver
DOM22_RS17630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DOM22_RS17635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOM22_RS17645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DOM22_RS17670	COG0596	Alpha beta hydrolase
DOM22_RS17670	COG2945	thiolester hydrolase activity
DOM22_RS17675	COG0617	tRNA 3'-terminal CCA addition
DOM22_RS17685	COG2201	protein-glutamate methylesterase activity
DOM22_RS17690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DOM22_RS17695	COG2198	Histidine kinase
DOM22_RS17695	COG0643	Histidine kinase
DOM22_RS17700	COG0835	chemotaxis
DOM22_RS17715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DOM22_RS17720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DOM22_RS17745	COG0596	Alpha beta hydrolase
DOM22_RS17750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DOM22_RS17755	COG1169	isochorismate synthase
DOM22_RS17760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DOM22_RS17760	COG1605	Chorismate mutase
DOM22_RS17765	COG2226	methyltransferase
DOM22_RS17780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DOM22_RS17795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DOM22_RS17800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DOM22_RS17810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DOM22_RS17820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DOM22_RS17860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DOM22_RS17895	COG1309	transcriptional regulator
DOM22_RS17900	COG0768	penicillin binding
DOM22_RS17915	COG0708	Exodeoxyribonuclease III
DOM22_RS17940	COG0793	Belongs to the peptidase S41A family
DOM22_RS17945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOM22_RS17980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DOM22_RS17990	COG2897	thiosulfate sulfurtransferase activity
DOM22_RS18025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DOM22_RS18030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DOM22_RS18040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DOM22_RS18045	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DOM22_RS18065	COG1683	Conserved Protein
DOM22_RS18070	COG0488	(ABC) transporter
DOM22_RS18085	COG0488	(ABC) transporter
DOM22_RS18110	COG0439	Biotin carboxylase
DOM22_RS18115	COG5006	permease, DMT superfamily
DOM22_RS18120	COG1024	Enoyl-CoA hydratase
DOM22_RS18125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DOM22_RS18155	COG4555	ABC transporter
DOM22_RS18185	COG0415	Belongs to the DNA photolyase family
DOM22_RS18210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DOM22_RS18245	COG0583	DNA-binding transcription factor activity
DOM22_RS18255	COG2234	aminopeptidase activity
DOM22_RS18270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DOM22_RS18285	COG0517	IMP dehydrogenase activity
DOM22_RS18295	COG0702	epimerase
DOM22_RS18300	COG0514	ATP-dependent DNA helicase (RecQ)
DOM22_RS18305	COG0667	Aldo Keto reductase
DOM22_RS18330	COG0488	(ABC) transporter
DOM22_RS18400	COG0583	DNA-binding transcription factor activity
DOM22_RS18405	COG1741	Belongs to the pirin family
DOM22_RS18425	COG0840	transmembrane signaling receptor activity
DOM22_RS18430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DOM22_RS18450	COG0708	Exodeoxyribonuclease III
DOM22_RS18455	COG0702	epimerase
DOM22_RS18460	COG1733	regulation of RNA biosynthetic process
DOM22_RS18485	COG0071	Belongs to the small heat shock protein (HSP20) family
DOM22_RS18510	COG1215	transferase activity, transferring glycosyl groups
DOM22_RS18555	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DOM22_RS18575	COG1573	uracil-dna glycosylase
DOM22_RS18580	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DOM22_RS18590	COG1028	Short-chain dehydrogenase reductase Sdr
DOM22_RS18620	COG0640	Transcriptional regulator
DOM22_RS18655	COG1309	transcriptional regulator
DOM22_RS18660	COG0300	oxidoreductase activity
DOM22_RS18670	COG0300	oxidoreductase activity
DOM22_RS18675	COG1309	transcriptional regulator
DOM22_RS18730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DOM22_RS18745	COG0538	isocitrate dehydrogenase activity
DOM22_RS18760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOM22_RS18765	COG3958	Transketolase
DOM22_RS18770	COG3959	Transketolase, thiamine diphosphate binding domain
DOM22_RS18780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOM22_RS18790	COG0463	Glycosyl transferase, family 2
DOM22_RS18805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOM22_RS18865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DOM22_RS18870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DOM22_RS18875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DOM22_RS18880	COG1100	Small GTP-binding protein
DOM22_RS18895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DOM22_RS18950	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DOM22_RS18955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DOM22_RS18975	COG3852	Histidine kinase
DOM22_RS18980	COG2204	response regulator
DOM22_RS18990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DOM22_RS18995	COG0740	serine-type endopeptidase activity
DOM22_RS19000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DOM22_RS19005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOM22_RS19040	COG0544	peptidyl-prolyl cis-trans isomerase activity
DOM22_RS19055	COG0596	Alpha beta hydrolase
DOM22_RS19065	COG0793	Belongs to the peptidase S41A family
DOM22_RS19075	COG2177	Part of the ABC transporter FtsEX involved in
DOM22_RS19080	COG2884	Cell division ATP-binding protein ftsE
DOM22_RS19095	COG1970	mechanosensitive ion channel activity
DOM22_RS19110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DOM22_RS19115	COG1132	(ABC) transporter
DOM22_RS19140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DOM22_RS19165	COG1472	Belongs to the glycosyl hydrolase 3 family
DOM22_RS19190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DOM22_RS19200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DOM22_RS19215	COG0052	Belongs to the universal ribosomal protein uS2 family
DOM22_RS19220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DOM22_RS19225	COG0528	UMP kinase activity
DOM22_RS19230	COG0233	cytoplasmic translational termination
DOM22_RS19235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DOM22_RS19240	COG4589	Belongs to the CDS family
DOM22_RS19245	COG0750	zinc metalloprotease
DOM22_RS19250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DOM22_RS19265	COG0564	pseudouridine synthase activity
DOM22_RS19270	COG1496	oxidoreductase activity
DOM22_RS19275	COG2094	Belongs to the DNA glycosylase MPG family
DOM22_RS19280	COG0783	Belongs to the Dps family
DOM22_RS19290	COG0626	cystathionine gamma-synthase activity
DOM22_RS19330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DOM22_RS19340	COG1127	ABC transporter
DOM22_RS19345	COG1127	ABC transporter
DOM22_RS19350	COG0045	succinate-CoA ligase (ADP-forming) activity
DOM22_RS19355	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DOM22_RS19380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOM22_RS19385	COG2942	2-epimerase
DOM22_RS19395	COG0105	UTP biosynthetic process
DOM22_RS19400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOM22_RS19410	COG1426	Protein conserved in bacteria
DOM22_RS19425	COG2871	sodium ion transport
DOM22_RS19430	COG2176	DNA-directed DNA polymerase activity
DOM22_RS19435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DOM22_RS19435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DOM22_RS19455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOM22_RS19470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DOM22_RS19475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DOM22_RS19480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DOM22_RS19485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DOM22_RS19490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DOM22_RS19500	COG1530	ribonuclease E activity
DOM22_RS19510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DOM22_RS19535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DOM22_RS19540	COG0439	Biotin carboxylase
DOM22_RS19550	COG0805	protein transport
DOM22_RS19555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOM22_RS19570	COG0612	Peptidase, M16
DOM22_RS19575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOM22_RS19580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DOM22_RS19585	COG0484	heat shock protein binding
DOM22_RS19605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DOM22_RS19650	COG1007	ATP synthesis coupled electron transport
DOM22_RS19665	COG0713	ATP synthesis coupled electron transport
DOM22_RS19675	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DOM22_RS19680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOM22_RS19695	COG1472	Belongs to the glycosyl hydrolase 3 family
DOM22_RS19700	COG0322	excinuclease ABC activity
DOM22_RS19705	COG1199	ATP-dependent helicase activity
DOM22_RS19705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DOM22_RS19715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DOM22_RS19720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DOM22_RS19725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DOM22_RS19730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DOM22_RS19735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOM22_RS19740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DOM22_RS19760	COG1192	Involved in chromosome partitioning
DOM22_RS19770	COG0357	Ribosomal RNA small subunit methyltransferase G
DOM22_RS19775	COG0445	tRNA wobble uridine modification
DOM22_RS19780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DOM22_RS19790	COG0706	membrane insertase activity
DOM22_RS19795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane