locus-tag	class	description
AL038_RS00120	COG2356	endonuclease I
AL038_RS00125	COG4974	Belongs to the 'phage' integrase family
AL038_RS00260	COG3034	peptidoglycan biosynthetic process
AL038_RS00265	COG0315	cyclic pyranopterin monophosphate synthase activity
AL038_RS00270	COG1763	Mo-molybdopterin cofactor biosynthetic process
AL038_RS00275	COG0746	molybdenum cofactor guanylyltransferase activity
AL038_RS00295	COG1196	nuclear chromosome segregation
AL038_RS00305	COG0196	riboflavin kinase activity
AL038_RS00310	COG0728	peptidoglycan biosynthetic process
AL038_RS00315	COG0316	Belongs to the HesB IscA family
AL038_RS00335	COG4251	negative regulation of phosphorylation
AL038_RS00335	COG5001	Diguanylate cyclase
AL038_RS00335	COG3706	GGDEF domain
AL038_RS00335	COG2203	Gaf domain
AL038_RS00345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL038_RS00345	COG0519	Catalyzes the synthesis of GMP from XMP
AL038_RS00360	COG3293	Transposase
AL038_RS00380	COG1530	ribonuclease E activity
AL038_RS00385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL038_RS00395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL038_RS00400	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL038_RS00405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL038_RS00420	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL038_RS00430	COG0653	protein targeting
AL038_RS00435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AL038_RS00455	COG1487	ribonuclease activity
AL038_RS00475	COG0129	dihydroxy-acid dehydratase activity
AL038_RS00510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL038_RS00515	COG1850	ribulose-bisphosphate carboxylase activity
AL038_RS00520	COG4451	ribulose bisphosphate carboxylase, small
AL038_RS00525	COG0741	lytic transglycosylase activity
AL038_RS00525	COG1388	LysM domain
AL038_RS00530	COG0688	phosphatidylethanolamine metabolic process
AL038_RS00535	COG2847	Copper chaperone PCu(A)C
AL038_RS00550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL038_RS00565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL038_RS00585	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AL038_RS00590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL038_RS00625	COG1690	Belongs to the RtcB family
AL038_RS00640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL038_RS00645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL038_RS00705	COG0004	ammonium transporteR
AL038_RS00725	COG3128	pkhd-type hydroxylase
AL038_RS00730	COG4774	siderophore transport
AL038_RS00740	COG1923	regulation of RNA biosynthetic process
AL038_RS00750	COG3885	ferrous iron binding
AL038_RS00750	COG2078	PFAM AMMECR1 domain protein
AL038_RS00755	COG1355	regulation of microtubule-based process
AL038_RS00785	COG2878	Part of a membrane complex involved in electron transport
AL038_RS00790	COG4656	Part of a membrane complex involved in electron transport
AL038_RS00805	COG4658	electron transport chain
AL038_RS00810	COG4659	FMN binding
AL038_RS00825	COG2319	Wd-40 repeat
AL038_RS00825	COG4249	Peptidase C14 caspase catalytic subunit p20
AL038_RS00845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL038_RS00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL038_RS00895	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL038_RS00900	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL038_RS00905	COG0594	ribonuclease P activity
AL038_RS00910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL038_RS00915	COG0706	membrane insertase activity
AL038_RS00930	COG0438	transferase activity, transferring glycosyl groups
AL038_RS00930	COG1216	Glycosyl transferase, family 2
AL038_RS00935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL038_RS00940	COG0798	PFAM Bile acid sodium symporter
AL038_RS00945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL038_RS00960	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL038_RS00985	COG0736	holo-[acyl-carrier-protein] synthase activity
AL038_RS00990	COG0702	epimerase
AL038_RS01000	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AL038_RS01010	COG1368	sulfuric ester hydrolase activity
AL038_RS01020	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL038_RS01035	COG0745	RESPONSE REGULATOR receiver
AL038_RS01050	COG2989	Protein conserved in bacteria
AL038_RS01055	COG3108	Peptidase M15
AL038_RS01105	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL038_RS01110	COG2205	protein histidine kinase activity
AL038_RS01110	COG3437	response regulator, receiver
AL038_RS01110	COG3850	Histidine kinase
AL038_RS01110	COG4999	Histidine kinase
AL038_RS01115	COG0784	Response regulator, receiver
AL038_RS01115	COG5002	protein histidine kinase activity
AL038_RS01115	COG2205	protein histidine kinase activity
AL038_RS01135	COG0730	response to heat
AL038_RS01140	COG0802	atpase or kinase
AL038_RS01170	COG1136	(ABC) transporter
AL038_RS01175	COG1136	(ABC) transporter
AL038_RS01175	COG0577	efflux transmembrane transporter activity
AL038_RS01180	COG0210	DNA helicase
AL038_RS01225	COG1662	PFAM IS1 transposase
AL038_RS01235	COG0445	tRNA wobble uridine modification
AL038_RS01270	COG2165	general secretion pathway protein
AL038_RS01290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL038_RS01295	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AL038_RS01360	COG1662	PFAM IS1 transposase
AL038_RS01375	COG3850	Histidine kinase
AL038_RS01375	COG2205	protein histidine kinase activity
AL038_RS01375	COG3437	response regulator, receiver
AL038_RS01375	COG4999	Histidine kinase
AL038_RS01405	COG2949	membrane
AL038_RS01410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL038_RS01415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL038_RS01450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL038_RS01510	COG3264	Mechanosensitive ion channel
AL038_RS01510	COG1196	nuclear chromosome segregation
AL038_RS01525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL038_RS01530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL038_RS01545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL038_RS01550	COG0546	phosphoglycolate phosphatase activity
AL038_RS01570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL038_RS01575	COG0259	pyridoxamine-phosphate oxidase activity
AL038_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS01595	COG2205	protein histidine kinase activity
AL038_RS01605	COG2226	methyltransferase
AL038_RS01625	COG0840	transmembrane signaling receptor activity
AL038_RS01640	COG0842	Transport permease protein
AL038_RS01645	COG1131	(ABC) transporter
AL038_RS01650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL038_RS01675	COG4172	Belongs to the ABC transporter superfamily
AL038_RS01680	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL038_RS01690	COG2198	Histidine kinase
AL038_RS01690	COG5002	protein histidine kinase activity
AL038_RS01690	COG0784	Response regulator, receiver
AL038_RS01695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL038_RS01705	COG2205	protein histidine kinase activity
AL038_RS01705	COG0784	Response regulator, receiver
AL038_RS01730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL038_RS01735	COG0571	ribonuclease III activity
AL038_RS01750	COG0481	GTPase activity
AL038_RS01760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL038_RS01775	COG0189	ligase activity
AL038_RS01780	COG1773	rubredoxin
AL038_RS01810	COG0741	lytic transglycosylase activity
AL038_RS01825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL038_RS01830	COG1132	(ABC) transporter
AL038_RS01840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL038_RS01845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL038_RS01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL038_RS01880	COG1662	PFAM IS1 transposase
AL038_RS01885	COG2239	Acts as a magnesium transporter
AL038_RS01910	COG0747	negative chemotaxis
AL038_RS01925	COG2192	nodulation
AL038_RS01940	COG0488	(ABC) transporter
AL038_RS01945	COG5002	protein histidine kinase activity
AL038_RS01945	COG2205	protein histidine kinase activity
AL038_RS01945	COG0784	Response regulator, receiver
AL038_RS01950	COG3852	Histidine kinase
AL038_RS01960	COG3290	protein histidine kinase activity
AL038_RS01960	COG3829	transcription factor binding
AL038_RS01975	COG0784	Response regulator, receiver
AL038_RS01975	COG2205	protein histidine kinase activity
AL038_RS01975	COG5002	protein histidine kinase activity
AL038_RS01980	COG3391	amine dehydrogenase activity
AL038_RS01990	COG2884	Cell division ATP-binding protein ftsE
AL038_RS01995	COG0142	geranyltranstransferase activity
AL038_RS02000	COG0529	Catalyzes the synthesis of activated sulfate
AL038_RS02015	COG2096	Adenosyltransferase
AL038_RS02025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL038_RS02030	COG2119	membrane
AL038_RS02035	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL038_RS02045	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL038_RS02055	COG3850	Histidine kinase
AL038_RS02085	COG1126	abc transporter atp-binding protein
AL038_RS02105	COG0310	cobalt ion transport
AL038_RS02110	COG0310	cobalt ion transport
AL038_RS02120	COG5001	Diguanylate cyclase
AL038_RS02120	COG5002	protein histidine kinase activity
AL038_RS02135	COG0436	Aminotransferase
AL038_RS02140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL038_RS02150	COG3311	Transcriptional regulator
AL038_RS02155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL038_RS02165	COG2205	protein histidine kinase activity
AL038_RS02165	COG0784	Response regulator, receiver
AL038_RS02190	COG0475	glutathione-regulated potassium exporter activity
AL038_RS02225	COG3409	Peptidoglycan-binding domain 1 protein
AL038_RS02225	COG3267	Type II secretory pathway component ExeA
AL038_RS02230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL038_RS02240	COG0742	ribosomal rna small subunit methyltransferase
AL038_RS02260	COG2885	chlorophyll binding
AL038_RS02265	COG0159	tryptophan synthase activity
AL038_RS02270	COG0133	tryptophan synthase activity
AL038_RS02275	COG1960	acyl-CoA dehydrogenase activity
AL038_RS02280	COG1960	acyl-CoA dehydrogenase activity
AL038_RS02310	COG2204	response regulator
AL038_RS02315	COG2363	Small membrane protein
AL038_RS02320	COG0142	geranyltranstransferase activity
AL038_RS02330	COG0582	viral genome integration into host DNA
AL038_RS02360	COG1598	PFAM Uncharacterised protein family UPF0150
AL038_RS02415	COG3293	Transposase
AL038_RS02430	COG1598	PFAM Uncharacterised protein family UPF0150
AL038_RS02470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL038_RS02490	COG0500	methyltransferase
AL038_RS02495	COG2967	ApaG domain
AL038_RS02500	COG2226	methyltransferase
AL038_RS02505	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL038_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS02525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL038_RS02530	COG0784	Response regulator, receiver
AL038_RS02530	COG2205	protein histidine kinase activity
AL038_RS02535	COG0604	alcohol dehydrogenase
AL038_RS02540	COG3240	lipase activity
AL038_RS02550	COG2205	protein histidine kinase activity
AL038_RS02550	COG0784	Response regulator, receiver
AL038_RS02580	COG0071	Belongs to the small heat shock protein (HSP20) family
AL038_RS02590	COG1570	exodeoxyribonuclease VII activity
AL038_RS02595	COG1051	belongs to the nudix hydrolase family
AL038_RS02610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL038_RS02615	COG4942	peptidase
AL038_RS02635	COG0484	heat shock protein binding
AL038_RS02640	COG0402	S-adenosylhomocysteine deaminase activity
AL038_RS02655	COG3293	Transposase
AL038_RS02670	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AL038_RS02675	COG0527	aspartate kinase activity
AL038_RS02680	COG0784	Response regulator, receiver
AL038_RS02680	COG2205	protein histidine kinase activity
AL038_RS02700	COG2030	dehydratase
AL038_RS02705	COG0165	Argininosuccinate lyase
AL038_RS02715	COG0505	Belongs to the CarA family
AL038_RS02720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL038_RS02725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL038_RS02740	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AL038_RS02745	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AL038_RS02750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AL038_RS02755	COG2373	Large extracellular alpha-helical protein
AL038_RS02760	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AL038_RS02770	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AL038_RS02785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL038_RS02815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL038_RS02820	COG0149	triose-phosphate isomerase activity
AL038_RS02825	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL038_RS02830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AL038_RS02835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL038_RS02855	COG3597	protein domain associated with
AL038_RS02875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL038_RS02930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL038_RS02935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL038_RS02955	COG0069	glutamate synthase activity
AL038_RS02965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL038_RS02980	COG0303	'Molybdopterin
AL038_RS02990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL038_RS03025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL038_RS03030	COG0840	transmembrane signaling receptor activity
AL038_RS03050	COG0784	Response regulator, receiver
AL038_RS03050	COG2198	Histidine kinase
AL038_RS03050	COG5002	protein histidine kinase activity
AL038_RS03060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL038_RS03075	COG0584	glycerophosphoryl diester phosphodiesterase
AL038_RS03090	COG0840	transmembrane signaling receptor activity
AL038_RS03095	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AL038_RS03100	COG3954	Phosphoribulokinase
AL038_RS03110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL038_RS03110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL038_RS03115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL038_RS03140	COG0837	glucose binding
AL038_RS03160	COG0792	nuclease activity
AL038_RS03170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL038_RS03175	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL038_RS03180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL038_RS03195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL038_RS03200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL038_RS03235	COG0741	lytic transglycosylase activity
AL038_RS03240	COG2205	protein histidine kinase activity
AL038_RS03240	COG5002	protein histidine kinase activity
AL038_RS03240	COG0784	Response regulator, receiver
AL038_RS03260	COG2885	chlorophyll binding
AL038_RS03280	COG1166	arginine decarboxylase activity
AL038_RS03305	COG0322	excinuclease ABC activity
AL038_RS03320	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL038_RS03340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL038_RS03350	COG0359	binds to the 23S rRNA
AL038_RS03355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL038_RS03360	COG0360	Binds together with S18 to 16S ribosomal RNA
AL038_RS03365	COG1765	OsmC-like protein
AL038_RS03370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL038_RS03375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL038_RS03385	COG0183	Belongs to the thiolase family
AL038_RS03390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL038_RS03440	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL038_RS03460	COG1858	cytochrome C peroxidase
AL038_RS03495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL038_RS03500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL038_RS03505	COG4133	protoheme IX ABC transporter activity
AL038_RS03525	COG1129	ABC transporter
AL038_RS03550	COG0321	lipoyl(octanoyl) transferase activity
AL038_RS03555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL038_RS03580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS03580	COG2205	protein histidine kinase activity
AL038_RS03585	COG0375	protein maturation
AL038_RS03590	COG0298	carbon dioxide binding
AL038_RS03600	COG0493	'glutamate synthase
AL038_RS03605	COG0069	glutamate synthase activity
AL038_RS03605	COG0067	glutamate synthase
AL038_RS03605	COG0070	glutamate synthase
AL038_RS03610	COG2918	glutathione biosynthetic process
AL038_RS03630	COG0735	belongs to the Fur family
AL038_RS03650	COG2914	Belongs to the UPF0125 (RnfH) family
AL038_RS03665	COG4658	electron transport chain
AL038_RS03670	COG4656	Part of a membrane complex involved in electron transport
AL038_RS03675	COG2878	Part of a membrane complex involved in electron transport
AL038_RS03680	COG4657	Part of a membrane complex involved in electron transport
AL038_RS03690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL038_RS03695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL038_RS03700	COG4660	Part of a membrane complex involved in electron transport
AL038_RS03720	COG1597	lipid kinase activity
AL038_RS03735	COG2862	Uncharacterized protein family, UPF0114
AL038_RS03745	COG1459	type II secretion system
AL038_RS03760	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AL038_RS03820	COG1758	RNA polymerase activity
AL038_RS03825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL038_RS03835	COG0006	proline dipeptidase activity
AL038_RS03850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL038_RS03855	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL038_RS03875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL038_RS03880	COG0418	dihydroorotase activity
AL038_RS03890	COG5001	Diguanylate cyclase
AL038_RS03890	COG2203	Gaf domain
AL038_RS03890	COG3706	GGDEF domain
AL038_RS03890	COG4251	negative regulation of phosphorylation
AL038_RS03900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL038_RS03905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL038_RS03915	COG0312	modulator of DNA gyrase
AL038_RS03940	COG1469	GTP cyclohydrolase I activity
AL038_RS03960	COG0745	RESPONSE REGULATOR receiver
AL038_RS03965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL038_RS03965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL038_RS03990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL038_RS04010	COG0330	HflC and HflK could
AL038_RS04015	COG0037	tRNA processing
AL038_RS04020	COG0560	Phosphoserine phosphatase
AL038_RS04030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL038_RS04035	COG0737	Belongs to the 5'-nucleotidase family
AL038_RS04055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS04060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL038_RS04070	COG1842	Phage shock protein A
AL038_RS04100	COG1116	anion transmembrane transporter activity
AL038_RS04115	COG5002	protein histidine kinase activity
AL038_RS04115	COG0784	Response regulator, receiver
AL038_RS04115	COG2205	protein histidine kinase activity
AL038_RS04125	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL038_RS04135	COG0215	cysteine-tRNA ligase activity
AL038_RS04145	COG0546	phosphoglycolate phosphatase activity
AL038_RS04165	COG5002	protein histidine kinase activity
AL038_RS04165	COG2198	Histidine kinase
AL038_RS04165	COG0784	Response regulator, receiver
AL038_RS04180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL038_RS04200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AL038_RS04230	COG3218	ABC-type transport auxiliary lipoprotein component
AL038_RS04265	COG3025	triphosphatase activity
AL038_RS04275	COG0583	DNA-binding transcription factor activity
AL038_RS04280	COG2770	Histidine kinase
AL038_RS04280	COG2208	phosphoserine phosphatase activity
AL038_RS04295	COG5002	protein histidine kinase activity
AL038_RS04295	COG2176	DNA-directed DNA polymerase activity
AL038_RS04300	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AL038_RS04300	COG0662	Cupin 2, conserved barrel domain protein
AL038_RS04305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL038_RS04320	COG3001	Fructosamine kinase
AL038_RS04330	COG0784	Response regulator, receiver
AL038_RS04330	COG2205	protein histidine kinase activity
AL038_RS04340	COG2197	response regulator
AL038_RS04370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL038_RS04380	COG3755	Protein conserved in bacteria
AL038_RS04385	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL038_RS04435	COG0312	modulator of DNA gyrase
AL038_RS04440	COG4797	methyltransferase
AL038_RS04440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL038_RS04455	COG1194	a g-specific adenine glycosylase
AL038_RS04460	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL038_RS04475	COG0357	Ribosomal RNA small subunit methyltransferase G
AL038_RS04480	COG2921	Belongs to the UPF0250 family
AL038_RS04485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL038_RS04495	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL038_RS04500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL038_RS04505	COG4999	Histidine kinase
AL038_RS04505	COG3850	Histidine kinase
AL038_RS04505	COG3437	response regulator, receiver
AL038_RS04505	COG2205	protein histidine kinase activity
AL038_RS04510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL038_RS04520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL038_RS04525	COG3320	Male sterility
AL038_RS04525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL038_RS04540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL038_RS04545	COG3604	Transcriptional regulator
AL038_RS04550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL038_RS04555	COG0730	response to heat
AL038_RS04565	COG3267	Type II secretory pathway component ExeA
AL038_RS04565	COG3409	Peptidoglycan-binding domain 1 protein
AL038_RS04590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL038_RS04595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL038_RS04595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL038_RS04615	COG1662	PFAM IS1 transposase
AL038_RS04630	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL038_RS04635	COG2202	Pas domain
AL038_RS04635	COG2205	protein histidine kinase activity
AL038_RS04650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL038_RS04665	COG2914	Belongs to the UPF0125 (RnfH) family
AL038_RS04685	COG0386	Belongs to the glutathione peroxidase family
AL038_RS04690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL038_RS04700	COG5265	(ABC) transporter
AL038_RS04715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AL038_RS04755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL038_RS04775	COG1773	rubredoxin
AL038_RS04780	COG2770	Histidine kinase
AL038_RS04780	COG2208	phosphoserine phosphatase activity
AL038_RS04790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL038_RS04795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL038_RS04800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL038_RS04805	COG0217	transcriptional regulatory protein
AL038_RS04810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL038_RS04825	COG1215	transferase activity, transferring glycosyl groups
AL038_RS04835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL038_RS04835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL038_RS04840	COG0285	dihydrofolate synthase activity
AL038_RS04845	COG0148	phosphopyruvate hydratase activity
AL038_RS04850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL038_RS04855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL038_RS04875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL038_RS04875	COG1017	nitric oxide dioxygenase activity
AL038_RS04885	COG0442	prolyl-tRNA aminoacylation
AL038_RS04900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL038_RS04910	COG0745	RESPONSE REGULATOR receiver
AL038_RS04915	COG0643	Histidine kinase
AL038_RS04915	COG2198	Histidine kinase
AL038_RS04920	COG0835	chemotaxis
AL038_RS04965	COG2132	Multicopper oxidase
AL038_RS04980	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL038_RS04985	COG4181	ATPase activity
AL038_RS05005	COG0753	catalase activity
AL038_RS05020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL038_RS05025	COG0784	Response regulator, receiver
AL038_RS05025	COG2198	Histidine kinase
AL038_RS05025	COG2205	protein histidine kinase activity
AL038_RS05030	COG1139	Iron-sulfur cluster binding protein
AL038_RS05035	COG1556	Lactate utilization protein
AL038_RS05040	COG0745	RESPONSE REGULATOR receiver
AL038_RS05045	COG2176	DNA-directed DNA polymerase activity
AL038_RS05045	COG5002	protein histidine kinase activity
AL038_RS05055	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL038_RS05070	COG0714	Associated with various cellular activities
AL038_RS05085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL038_RS05090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL038_RS05115	COG3293	Transposase
AL038_RS05120	COG5001	Diguanylate cyclase
AL038_RS05120	COG5002	protein histidine kinase activity
AL038_RS05150	COG3437	response regulator, receiver
AL038_RS05150	COG2205	protein histidine kinase activity
AL038_RS05150	COG4999	Histidine kinase
AL038_RS05150	COG3850	Histidine kinase
AL038_RS05155	COG3850	Histidine kinase
AL038_RS05155	COG4999	Histidine kinase
AL038_RS05155	COG2205	protein histidine kinase activity
AL038_RS05155	COG3437	response regulator, receiver
AL038_RS05175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL038_RS05190	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL038_RS05195	COG2050	protein possibly involved in aromatic compounds catabolism
AL038_RS05200	COG3437	response regulator, receiver
AL038_RS05200	COG4999	Histidine kinase
AL038_RS05200	COG2205	protein histidine kinase activity
AL038_RS05200	COG3850	Histidine kinase
AL038_RS05205	COG3706	GGDEF domain
AL038_RS05215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL038_RS05275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL038_RS05280	COG0277	FAD linked oxidase domain protein
AL038_RS05285	COG0247	lactate metabolic process
AL038_RS05310	COG3008	intermembrane lipid transfer
AL038_RS05315	COG2995	paraquat-inducible protein a
AL038_RS05340	COG0420	3'-5' exonuclease activity
AL038_RS05345	COG0784	Response regulator, receiver
AL038_RS05345	COG2198	Histidine kinase
AL038_RS05345	COG2205	protein histidine kinase activity
AL038_RS05360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL038_RS05405	COG2205	protein histidine kinase activity
AL038_RS05405	COG0784	Response regulator, receiver
AL038_RS05410	COG1942	4-Oxalocrotonate Tautomerase
AL038_RS05415	COG0464	growth
AL038_RS05430	COG0697	spore germination
AL038_RS05435	COG0463	Glycosyl transferase, family 2
AL038_RS05440	COG0339	signal peptide processing
AL038_RS05450	COG1131	(ABC) transporter
AL038_RS05470	COG0187	DNA topoisomerase II activity
AL038_RS05480	COG1662	PFAM IS1 transposase
AL038_RS05500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL038_RS05505	COG1053	succinate dehydrogenase
AL038_RS05510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL038_RS05515	COG2009	succinate dehydrogenase
AL038_RS05530	COG2176	DNA-directed DNA polymerase activity
AL038_RS05535	COG2943	transferase activity, transferring hexosyl groups
AL038_RS05545	COG0494	nUDIX hydrolase
AL038_RS05550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL038_RS05555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL038_RS05560	COG0519	Catalyzes the synthesis of GMP from XMP
AL038_RS05570	COG3116	cell division
AL038_RS05585	COG1643	Atp-dependent helicase
AL038_RS05595	COG0864	Transcriptional regulator
AL038_RS05600	COG0641	radical SAM
AL038_RS05605	COG5002	protein histidine kinase activity
AL038_RS05605	COG0784	Response regulator, receiver
AL038_RS05610	COG0252	asparaginase activity
AL038_RS05615	COG2217	Heavy metal translocating P-type atpase
AL038_RS05645	COG1918	ferrous iron import across plasma membrane
AL038_RS05665	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL038_RS05685	COG1472	Belongs to the glycosyl hydrolase 3 family
AL038_RS05715	COG2192	nodulation
AL038_RS05720	COG1662	PFAM IS1 transposase
AL038_RS05730	COG2192	nodulation
AL038_RS05770	COG0488	(ABC) transporter
AL038_RS05800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL038_RS05810	COG0793	Belongs to the peptidase S41A family
AL038_RS05815	COG4942	peptidase
AL038_RS05870	COG0546	phosphoglycolate phosphatase activity
AL038_RS05870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL038_RS05875	COG0277	FAD linked oxidase domain protein
AL038_RS05890	COG0151	Belongs to the GarS family
AL038_RS05895	COG0138	bifunctional purine biosynthesis protein purh
AL038_RS05950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL038_RS05975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL038_RS05990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL038_RS06005	COG2010	Cytochrome c
AL038_RS06020	COG3278	Belongs to the heme-copper respiratory oxidase family
AL038_RS06025	COG2217	Heavy metal translocating P-type atpase
AL038_RS06030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL038_RS06040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL038_RS06075	COG0523	cobalamin synthesis protein
AL038_RS06115	COG2890	protein-(glutamine-N5) methyltransferase activity
AL038_RS06125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL038_RS06130	COG0582	viral genome integration into host DNA
AL038_RS06135	COG0101	tRNA pseudouridine synthase activity
AL038_RS06145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL038_RS06150	COG0473	3-isopropylmalate dehydrogenase activity
AL038_RS06160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL038_RS06175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL038_RS06180	COG1217	gtp-binding protein TYPA
AL038_RS06185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL038_RS06190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL038_RS06200	COG2198	Histidine kinase
AL038_RS06200	COG0784	Response regulator, receiver
AL038_RS06200	COG5002	protein histidine kinase activity
AL038_RS06210	COG0641	radical SAM
AL038_RS06220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL038_RS06225	COG1132	(ABC) transporter
AL038_RS06230	COG1704	LemA family
AL038_RS06235	COG0084	hydrolase, TatD family'
AL038_RS06240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL038_RS06245	COG2205	protein histidine kinase activity
AL038_RS06245	COG0784	Response regulator, receiver
AL038_RS06250	COG0784	Response regulator, receiver
AL038_RS06250	COG5002	protein histidine kinase activity
AL038_RS06260	COG0270	DNA (cytosine-5-)-methyltransferase activity
AL038_RS06270	COG0156	8-amino-7-oxononanoate synthase activity
AL038_RS06275	COG2957	Belongs to the agmatine deiminase family
AL038_RS06290	COG0277	FAD linked oxidase domain protein
AL038_RS06300	COG0586	Pfam SNARE associated Golgi protein
AL038_RS06315	COG0488	(ABC) transporter
AL038_RS06325	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL038_RS06335	COG1012	belongs to the aldehyde dehydrogenase family
AL038_RS06345	COG2202	Pas domain
AL038_RS06345	COG2205	protein histidine kinase activity
AL038_RS06350	COG0563	adenylate kinase activity
AL038_RS06375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL038_RS06380	COG2255	four-way junction helicase activity
AL038_RS06385	COG0824	Thioesterase
AL038_RS06390	COG0811	peptide transport
AL038_RS06405	COG0823	Involved in the tonB-independent uptake of proteins
AL038_RS06410	COG2885	chlorophyll binding
AL038_RS06420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL038_RS06430	COG3577	Aspartyl protease
AL038_RS06440	COG0741	lytic transglycosylase activity
AL038_RS06455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL038_RS06515	COG0805	protein transport
AL038_RS06520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL038_RS06525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL038_RS06535	COG0140	phosphoribosyl-ATP diphosphatase activity
AL038_RS06545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL038_RS06555	COG0107	imidazoleglycerol-phosphate synthase activity
AL038_RS06560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL038_RS06565	COG0840	transmembrane signaling receptor activity
AL038_RS06585	COG2833	Protein of unknown function (DUF455)
AL038_RS06610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL038_RS06615	COG3047	cAMP biosynthetic process
AL038_RS06620	COG2202	Pas domain
AL038_RS06620	COG2205	protein histidine kinase activity
AL038_RS06635	COG0667	Aldo Keto reductase
AL038_RS06655	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AL038_RS06660	COG2204	response regulator
AL038_RS06670	COG0668	transmembrane transport
AL038_RS06675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL038_RS06680	COG0697	spore germination
AL038_RS06695	COG0574	Belongs to the PEP-utilizing enzyme family
AL038_RS06695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL038_RS06725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL038_RS06730	COG0009	L-threonylcarbamoyladenylate synthase
AL038_RS06735	COG0408	coproporphyrinogen oxidase activity
AL038_RS06740	COG4656	Part of a membrane complex involved in electron transport
AL038_RS06760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL038_RS06770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL038_RS06775	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL038_RS06790	COG1192	Involved in chromosome partitioning
AL038_RS06795	COG2204	response regulator
AL038_RS06800	COG2203	Gaf domain
AL038_RS06800	COG2199	diguanylate cyclase activity
AL038_RS06820	COG4717	serine-type aminopeptidase activity
AL038_RS06825	COG0288	reversible hydration of carbon dioxide
AL038_RS06870	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL038_RS06875	COG1160	GTP binding
AL038_RS06895	COG1960	acyl-CoA dehydrogenase activity
AL038_RS06905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL038_RS06910	COG0732	type I restriction modification DNA specificity domain
AL038_RS06915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL038_RS06930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS06945	COG0697	spore germination
AL038_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS06970	COG4191	Histidine kinase
AL038_RS06980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL038_RS07010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL038_RS07015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL038_RS07020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL038_RS07030	COG5000	phosphorelay sensor kinase activity
AL038_RS07035	COG2204	response regulator
AL038_RS07040	COG0569	domain protein
AL038_RS07055	COG0840	transmembrane signaling receptor activity
AL038_RS07085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL038_RS07090	COG0247	lactate metabolic process
AL038_RS07100	COG1640	4-alpha-glucanotransferase
AL038_RS07110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL038_RS07115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL038_RS07120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AL038_RS07125	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AL038_RS07125	COG0644	oxidoreductase
AL038_RS07135	COG0745	RESPONSE REGULATOR receiver
AL038_RS07140	COG2205	protein histidine kinase activity
AL038_RS07145	COG0352	thiamine-phosphate diphosphorylase activity
AL038_RS07155	COG2022	thiamine diphosphate biosynthetic process
AL038_RS07170	COG0438	transferase activity, transferring glycosyl groups
AL038_RS07200	COG3206	protein involved in exopolysaccharide biosynthesis
AL038_RS07200	COG0489	protein tyrosine kinase activity
AL038_RS07210	COG2358	TRAP transporter, solute receptor (TAXI family
AL038_RS07225	COG0784	Response regulator, receiver
AL038_RS07225	COG2205	protein histidine kinase activity
AL038_RS07240	COG2208	phosphoserine phosphatase activity
AL038_RS07250	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS07275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL038_RS07285	COG2226	methyltransferase
AL038_RS07295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL038_RS07305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL038_RS07315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL038_RS07325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL038_RS07330	COG0535	radical SAM domain protein
AL038_RS07340	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AL038_RS07365	COG1131	(ABC) transporter
AL038_RS07370	COG0616	signal peptide processing
AL038_RS07380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL038_RS07390	COG2264	protein methyltransferase activity
AL038_RS07395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL038_RS07410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL038_RS07430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL038_RS07435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL038_RS07440	COG1611	Belongs to the LOG family
AL038_RS07465	COG2920	part of a sulfur-relay system
AL038_RS07470	COG2168	tRNA wobble position uridine thiolation
AL038_RS07475	COG2923	Belongs to the DsrF TusC family
AL038_RS07480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL038_RS07485	COG0484	heat shock protein binding
AL038_RS07490	COG1215	transferase activity, transferring glycosyl groups
AL038_RS07500	COG0756	dUTP diphosphatase activity
AL038_RS07530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL038_RS07540	COG3293	Transposase
AL038_RS07545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL038_RS07565	COG1959	2 iron, 2 sulfur cluster binding
AL038_RS07570	COG1104	cysteine desulfurase activity
AL038_RS07575	COG1104	cysteine desulfurase activity
AL038_RS07590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL038_RS07595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL038_RS07605	COG0497	DNA recombination
AL038_RS07610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL038_RS07615	COG0617	tRNA 3'-terminal CCA addition
AL038_RS07655	COG0542	response to heat
AL038_RS07660	COG1968	undecaprenyl-diphosphatase activity
AL038_RS07670	COG3852	Histidine kinase
AL038_RS07675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL038_RS07680	COG2911	Protein conserved in bacteria
AL038_RS07695	COG4260	virion core protein, lumpy skin disease virus
AL038_RS07705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL038_RS07710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL038_RS07715	COG0686	Belongs to the AlaDH PNT family
AL038_RS07730	COG1610	YqeY-like protein
AL038_RS07735	COG0358	DNA primase activity
AL038_RS07750	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL038_RS07755	COG1137	ATPase activity
AL038_RS07760	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AL038_RS07775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AL038_RS07780	COG1662	PFAM IS1 transposase
AL038_RS07790	COG2304	oxidoreductase activity
AL038_RS07795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL038_RS07800	COG5002	protein histidine kinase activity
AL038_RS07800	COG0784	Response regulator, receiver
AL038_RS07800	COG2198	Histidine kinase
AL038_RS07825	COG2198	Histidine kinase
AL038_RS07825	COG2205	protein histidine kinase activity
AL038_RS07825	COG0784	Response regulator, receiver
AL038_RS07830	COG0012	GTP binding
AL038_RS07835	COG1083	cytidylyl-transferase
AL038_RS07845	COG2089	acid synthase
AL038_RS07855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL038_RS07860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL038_RS07865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL038_RS07875	COG0297	glycogen (starch) synthase activity
AL038_RS07880	COG0343	queuine tRNA-ribosyltransferase activity
AL038_RS07885	COG2202	Pas domain
AL038_RS07885	COG2205	protein histidine kinase activity
AL038_RS07915	COG3038	cytochrome b561
AL038_RS07935	COG2885	chlorophyll binding
AL038_RS07960	COG1660	Displays ATPase and GTPase activities
AL038_RS07965	COG0126	phosphoglycerate kinase activity
AL038_RS07970	COG2171	N-acyltransferase activity
AL038_RS07975	COG0436	Aminotransferase
AL038_RS07980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL038_RS07990	COG0745	RESPONSE REGULATOR receiver
AL038_RS07995	COG2205	protein histidine kinase activity
AL038_RS08000	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AL038_RS08005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AL038_RS08010	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AL038_RS08020	COG0180	Tryptophanyl-tRNA synthetase
AL038_RS08055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL038_RS08055	COG1199	ATP-dependent helicase activity
AL038_RS08060	COG0347	Belongs to the P(II) protein family
AL038_RS08070	COG0004	ammonium transporteR
AL038_RS08085	COG0837	glucose binding
AL038_RS08100	COG0105	UTP biosynthetic process
AL038_RS08105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL038_RS08115	COG1426	Protein conserved in bacteria
AL038_RS08120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL038_RS08125	COG0124	histidyl-tRNA synthetase
AL038_RS08130	COG2976	Protein conserved in bacteria
AL038_RS08140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS08140	COG2205	protein histidine kinase activity
AL038_RS08155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL038_RS08160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL038_RS08165	COG0302	gtp cyclohydrolase
AL038_RS08175	COG0430	RNA-3'-phosphate cyclase activity
AL038_RS08190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL038_RS08195	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AL038_RS08205	COG0330	HflC and HflK could
AL038_RS08210	COG0330	HflC and HflK could
AL038_RS08225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL038_RS08230	COG1923	regulation of RNA biosynthetic process
AL038_RS08235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL038_RS08240	COG1459	type II secretion system
AL038_RS08255	COG0494	nUDIX hydrolase
AL038_RS08260	COG0588	phosphoglycerate mutase activity
AL038_RS08270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL038_RS08275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL038_RS08280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL038_RS08290	COG0825	malonyl-CoA metabolic process
AL038_RS08305	COG0557	exoribonuclease II activity
AL038_RS08335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL038_RS08350	COG2165	general secretion pathway protein
AL038_RS08355	COG0484	heat shock protein binding
AL038_RS08380	COG0504	CTP synthase activity
AL038_RS08385	COG2084	Dehydrogenase
AL038_RS08395	COG1346	cytolysis
AL038_RS08410	COG2202	Pas domain
AL038_RS08410	COG2205	protein histidine kinase activity
AL038_RS08435	COG0752	glycyl-tRNA synthetase alpha subunit
AL038_RS08440	COG0751	glycine-tRNA ligase activity
AL038_RS08445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL038_RS08455	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL038_RS08455	COG1388	LysM domain
AL038_RS08460	COG4942	peptidase
AL038_RS08475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AL038_RS08500	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL038_RS08510	COG1138	Cytochrome C-type biogenesis protein
AL038_RS08520	COG2217	Heavy metal translocating P-type atpase
AL038_RS08535	COG0425	Belongs to the sulfur carrier protein TusA family
AL038_RS08540	COG2210	Belongs to the sulfur carrier protein TusA family
AL038_RS08545	COG0328	RNA-DNA hybrid ribonuclease activity
AL038_RS08555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL038_RS08575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL038_RS08580	COG0589	response to stress
AL038_RS08595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL038_RS08595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL038_RS08600	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL038_RS08605	COG3932	Exopolysaccharide synthesis, ExoD
AL038_RS08615	COG1196	nuclear chromosome segregation
AL038_RS08615	COG0741	lytic transglycosylase activity
AL038_RS08615	COG0739	heme binding
AL038_RS08620	COG0604	alcohol dehydrogenase
AL038_RS08630	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL038_RS08635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL038_RS08635	COG0515	serine threonine protein kinase
AL038_RS08640	COG2902	Dehydrogenase
AL038_RS08650	COG0573	inorganic phosphate transmembrane transporter activity
AL038_RS08655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL038_RS08660	COG0704	Plays a role in the regulation of phosphate uptake
AL038_RS08665	COG1496	oxidoreductase activity
AL038_RS08680	COG1960	acyl-CoA dehydrogenase activity
AL038_RS08690	COG3707	response regulator
AL038_RS08695	COG1116	anion transmembrane transporter activity
AL038_RS08695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL038_RS08700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL038_RS08705	COG1116	anion transmembrane transporter activity
AL038_RS08710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL038_RS08715	COG2146	nitrite reductase [NAD(P)H] activity
AL038_RS08720	COG0243	molybdopterin cofactor binding
AL038_RS08730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL038_RS08740	COG1562	ergosterol biosynthetic process
AL038_RS08745	COG0330	HflC and HflK could
AL038_RS08750	COG0390	transport system, permease component
AL038_RS08760	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
AL038_RS08775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL038_RS08780	COG0693	protein deglycase activity
AL038_RS08790	COG1216	Glycosyl transferase, family 2
AL038_RS08790	COG0438	transferase activity, transferring glycosyl groups
AL038_RS08800	COG0791	NLP P60 protein
AL038_RS08805	COG0450	alkyl hydroperoxide reductase
AL038_RS08835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL038_RS08840	COG1832	CoA-binding protein
AL038_RS08870	COG0166	Belongs to the GPI family
AL038_RS08895	COG4232	protein-disulfide reductase activity
AL038_RS08900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL038_RS08920	COG4191	Histidine kinase
AL038_RS08960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL038_RS08965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL038_RS08980	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AL038_RS09000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL038_RS09005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL038_RS09025	COG0438	transferase activity, transferring glycosyl groups
AL038_RS09030	COG0367	asparagine synthase
AL038_RS09035	COG0463	Glycosyl transferase, family 2
AL038_RS09045	COG4106	trans-aconitate 2-methyltransferase activity
AL038_RS09055	COG3300	MHYT domain
AL038_RS09055	COG5001	Diguanylate cyclase
AL038_RS09060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL038_RS09065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL038_RS09070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL038_RS09075	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL038_RS09080	COG0649	NAD binding
AL038_RS09085	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AL038_RS09095	COG1034	ATP synthesis coupled electron transport
AL038_RS09100	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AL038_RS09105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL038_RS09120	COG0713	ATP synthesis coupled electron transport
AL038_RS09135	COG1007	ATP synthesis coupled electron transport
AL038_RS09140	COG1555	photosystem II stabilization
AL038_RS09145	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL038_RS09150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL038_RS09170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL038_RS09180	COG0356	it plays a direct role in the translocation of protons across the membrane
AL038_RS09185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL038_RS09190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL038_RS09195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL038_RS09200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL038_RS09205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL038_RS09210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL038_RS09215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL038_RS09220	COG3284	Transcriptional regulator
AL038_RS09235	COG3012	SEC-C Motif Domain Protein
AL038_RS09240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL038_RS09245	COG1127	ABC transporter
AL038_RS09255	COG2198	Histidine kinase
AL038_RS09255	COG5002	protein histidine kinase activity
AL038_RS09255	COG0784	Response regulator, receiver
AL038_RS09265	COG0501	Belongs to the peptidase M48B family
AL038_RS09275	COG0515	serine threonine protein kinase
AL038_RS09275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL038_RS09505	COG2842	Transposition protein
AL038_RS09510	COG2801	Transposase and inactivated derivatives
AL038_RS09575	COG3275	phosphorelay sensor kinase activity
AL038_RS09600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL038_RS09605	COG0085	RNA polymerase activity
AL038_RS09610	COG0222	ribosome binding
AL038_RS09615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL038_RS09620	COG0081	regulation of translation
AL038_RS09625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL038_RS09635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL038_RS09645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL038_RS09675	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL038_RS09695	COG1573	uracil-dna glycosylase
AL038_RS09725	COG2205	protein histidine kinase activity
AL038_RS09725	COG0784	Response regulator, receiver
AL038_RS09730	COG2203	Gaf domain
AL038_RS09730	COG3706	GGDEF domain
AL038_RS09730	COG4251	negative regulation of phosphorylation
AL038_RS09730	COG5001	Diguanylate cyclase
AL038_RS09745	COG3302	dmso reductase anchor subunit
AL038_RS09750	COG0437	4 iron, 4 sulfur cluster binding
AL038_RS09755	COG0243	molybdopterin cofactor binding
AL038_RS09760	COG0552	protein localization to endoplasmic reticulum
AL038_RS09770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL038_RS09770	COG0515	serine threonine protein kinase
AL038_RS09805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AL038_RS09820	COG0019	diaminopimelate decarboxylase activity
AL038_RS09840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL038_RS09880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL038_RS09905	COG0523	cobalamin synthesis protein
AL038_RS09915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL038_RS09925	COG0033	Phosphoglucomutase
AL038_RS09935	COG0723	plastoquinol--plastocyanin reductase activity
AL038_RS09940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL038_RS09945	COG2857	Cytochrome c1
AL038_RS09950	COG2969	positive regulation of protein catabolic process
AL038_RS09960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL038_RS09965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL038_RS09970	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL038_RS09975	COG2226	methyltransferase
AL038_RS09985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL038_RS09990	COG4137	Cytochrome C assembly protein
AL038_RS10005	COG0768	penicillin binding
AL038_RS10010	COG0784	Response regulator, receiver
AL038_RS10010	COG3437	response regulator, receiver
AL038_RS10015	COG1519	Transferase
AL038_RS10020	COG0183	Belongs to the thiolase family
AL038_RS10030	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS10090	COG0237	dephospho-CoA kinase activity
AL038_RS10095	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL038_RS10120	COG0840	transmembrane signaling receptor activity
AL038_RS10125	COG0643	Histidine kinase
AL038_RS10125	COG0784	Response regulator, receiver
AL038_RS10125	COG2198	Histidine kinase
AL038_RS10155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL038_RS10165	COG0443	Heat shock 70 kDa protein
AL038_RS10175	COG0791	NLP P60 protein
AL038_RS10185	COG1846	Transcriptional regulator
AL038_RS10190	COG2703	oxygen carrier activity
AL038_RS10200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL038_RS10205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL038_RS10210	COG1538	Outer membrane efflux protein
AL038_RS10215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL038_RS10235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL038_RS10240	COG2813	Specifically methylates the guanine in position
AL038_RS10240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL038_RS10250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL038_RS10255	COG0254	rRNA binding
AL038_RS10270	COG1131	(ABC) transporter
AL038_RS10280	COG0602	queuosine metabolic process
AL038_RS10285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL038_RS10290	COG0484	heat shock protein binding
AL038_RS10295	COG0443	Heat shock 70 kDa protein
AL038_RS10300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL038_RS10305	COG1420	regulation of RNA biosynthetic process
AL038_RS10320	COG0708	Exodeoxyribonuclease III
AL038_RS10330	COG0753	catalase activity
AL038_RS10335	COG2010	Cytochrome c
AL038_RS10340	COG4999	Histidine kinase
AL038_RS10340	COG3850	Histidine kinase
AL038_RS10340	COG2205	protein histidine kinase activity
AL038_RS10340	COG3437	response regulator, receiver
AL038_RS10375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL038_RS10430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL038_RS10435	COG2814	Major facilitator Superfamily
AL038_RS10450	COG0463	Glycosyl transferase, family 2
AL038_RS10455	COG1965	Belongs to the frataxin family
AL038_RS10470	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS10505	COG4783	chaperone-mediated protein folding
AL038_RS10515	COG1131	(ABC) transporter
AL038_RS10530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL038_RS10545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL038_RS10560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL038_RS10590	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL038_RS10605	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL038_RS10610	COG3383	formate dehydrogenase (NAD+) activity
AL038_RS10620	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AL038_RS10635	COG3158	transport of potassium into the cell
AL038_RS10650	COG0084	hydrolase, TatD family'
AL038_RS10655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL038_RS10665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL038_RS10670	COG0464	growth
AL038_RS10690	COG3411	Ferredoxin
AL038_RS10705	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AL038_RS10720	COG2304	oxidoreductase activity
AL038_RS10760	COG0513	Belongs to the DEAD box helicase family
AL038_RS10770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL038_RS10790	COG1136	(ABC) transporter
AL038_RS10795	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL038_RS10800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL038_RS10815	COG1131	(ABC) transporter
AL038_RS10820	COG0842	Transport permease protein
AL038_RS10825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL038_RS10830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL038_RS10835	COG1862	Preprotein translocase
AL038_RS10855	COG1024	Enoyl-CoA hydratase
AL038_RS10895	COG2177	Part of the ABC transporter FtsEX involved in
AL038_RS10905	COG2003	Belongs to the UPF0758 family
AL038_RS10930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL038_RS10940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL038_RS10945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL038_RS10955	COG2201	protein-glutamate methylesterase activity
AL038_RS10970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL038_RS10970	COG0616	signal peptide processing
AL038_RS11060	COG0167	dihydroorotate dehydrogenase activity
AL038_RS11070	COG1643	Atp-dependent helicase
AL038_RS11080	COG1858	cytochrome C peroxidase
AL038_RS11100	COG0583	DNA-binding transcription factor activity
AL038_RS11105	COG0784	Response regulator, receiver
AL038_RS11105	COG2205	protein histidine kinase activity
AL038_RS11110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL038_RS11135	COG3258	Cytochrome c
AL038_RS11140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL038_RS11145	COG0714	Associated with various cellular activities
AL038_RS11155	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AL038_RS11165	COG3293	Transposase
AL038_RS11180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL038_RS11185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL038_RS11195	COG3245	cytochrome
AL038_RS11220	COG0784	Response regulator, receiver
AL038_RS11220	COG2205	protein histidine kinase activity
AL038_RS11240	COG5464	transposase or invertase
AL038_RS11260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL038_RS11275	COG0795	lipopolysaccharide-transporting ATPase activity
AL038_RS11290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL038_RS11320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL038_RS11335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL038_RS11340	COG2894	cell division
AL038_RS11345	COG0850	regulation of cytokinetic process
AL038_RS11405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL038_RS11410	COG3384	dioxygenase
AL038_RS11415	COG1741	Belongs to the pirin family
AL038_RS11425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL038_RS11430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL038_RS11455	COG1662	PFAM IS1 transposase
AL038_RS11495	COG2319	Wd-40 repeat
AL038_RS11495	COG4249	Peptidase C14 caspase catalytic subunit p20
AL038_RS11510	COG1012	belongs to the aldehyde dehydrogenase family
AL038_RS11540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL038_RS11550	COG1605	Chorismate mutase
AL038_RS11550	COG0077	Prephenate dehydratase
AL038_RS11555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL038_RS11575	COG0582	viral genome integration into host DNA
AL038_RS11645	COG0640	Transcriptional regulator
AL038_RS11655	COG2890	protein-(glutamine-N5) methyltransferase activity
AL038_RS11700	COG0643	Histidine kinase
AL038_RS11700	COG0784	Response regulator, receiver
AL038_RS11700	COG2198	Histidine kinase
AL038_RS11745	COG0784	Response regulator, receiver
AL038_RS11745	COG5002	protein histidine kinase activity
AL038_RS11745	COG2205	protein histidine kinase activity
AL038_RS11750	COG0438	transferase activity, transferring glycosyl groups
AL038_RS11765	COG0047	phosphoribosylformylglycinamidine synthase activity
AL038_RS11765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL038_RS11770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL038_RS11780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL038_RS11785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL038_RS11800	COG4249	Peptidase C14 caspase catalytic subunit p20
AL038_RS11800	COG2319	Wd-40 repeat
AL038_RS11815	COG2308	Evidence 4 Homologs of previously reported genes of
AL038_RS11865	COG0650	Formate hydrogenlyase subunit 4
AL038_RS11895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL038_RS11910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL038_RS11915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL038_RS11920	COG4172	Belongs to the ABC transporter superfamily
AL038_RS11930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL038_RS11940	COG1280	lysine exporter protein (LysE YggA)
AL038_RS11965	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL038_RS11975	COG3180	Ammonia monooxygenase
AL038_RS11980	COG1234	tRNA 3'-trailer cleavage
AL038_RS11985	COG0745	RESPONSE REGULATOR receiver
AL038_RS11995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AL038_RS12010	COG2183	response to ionizing radiation
AL038_RS12015	COG5001	Diguanylate cyclase
AL038_RS12015	COG3300	MHYT domain
AL038_RS12025	COG0720	synthase
AL038_RS12040	COG1360	Flagellar Motor Protein
AL038_RS12060	COG4555	ABC transporter
AL038_RS12100	COG1064	alcohol dehydrogenase
AL038_RS12150	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AL038_RS12180	COG1733	regulation of RNA biosynthetic process
AL038_RS12185	COG0702	epimerase
AL038_RS12205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL038_RS12220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL038_RS12225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL038_RS12235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL038_RS12240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL038_RS12245	COG0494	nUDIX hydrolase
AL038_RS12270	COG0582	viral genome integration into host DNA
AL038_RS12280	COG2337	Toxic component of a toxin-antitoxin (TA) module
AL038_RS12300	COG2208	phosphoserine phosphatase activity
AL038_RS12315	COG1993	acr, cog1993
AL038_RS12320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL038_RS12325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL038_RS12330	COG0601	transmembrane transport
AL038_RS12345	COG3909	cytochrome
AL038_RS12390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL038_RS12395	COG1309	transcriptional regulator
AL038_RS12430	COG1842	Phage shock protein A
AL038_RS12445	COG0606	chelatase, subunit chli
AL038_RS12460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS12470	COG0863	Belongs to the N(4) N(6)-methyltransferase family
AL038_RS12490	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS12495	COG5635	Nacht domain
AL038_RS12495	COG2319	Wd-40 repeat
AL038_RS12520	COG0410	ABC transporter
AL038_RS12545	COG1022	Amp-dependent synthetase and ligase
AL038_RS12555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL038_RS12565	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AL038_RS12570	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AL038_RS12625	COG2205	protein histidine kinase activity
AL038_RS12625	COG3850	Histidine kinase
AL038_RS12625	COG4999	Histidine kinase
AL038_RS12625	COG3437	response regulator, receiver
AL038_RS12630	COG2205	protein histidine kinase activity
AL038_RS12640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL038_RS12655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AL038_RS12660	COG4208	sulfate ABC transporter
AL038_RS12665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AL038_RS12695	COG2354	Protein conserved in bacteria
AL038_RS12700	COG0352	thiamine-phosphate diphosphorylase activity
AL038_RS12705	COG0564	pseudouridine synthase activity
AL038_RS12735	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL038_RS12745	COG3550	peptidyl-serine autophosphorylation
AL038_RS12755	COG4953	penicillin-binding protein 1C
AL038_RS12765	COG1858	cytochrome C peroxidase
AL038_RS12775	COG1408	metallophosphoesterase
AL038_RS12820	COG0742	ribosomal rna small subunit methyltransferase
AL038_RS12835	COG0667	Aldo Keto reductase
AL038_RS12850	COG3293	Transposase
AL038_RS12870	COG0459	protein refolding
AL038_RS12875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL038_RS12885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL038_RS12890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL038_RS12900	COG0018	arginyl-trna synthetase
AL038_RS12905	COG1686	Belongs to the peptidase S11 family
AL038_RS12910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL038_RS12915	COG2951	lytic endotransglycosylase activity
AL038_RS12920	COG0772	Belongs to the SEDS family
AL038_RS12925	COG4566	intracellular signal transduction
AL038_RS12935	COG0281	malic enzyme
AL038_RS12935	COG0280	phosphate acetyltransferase
AL038_RS12950	COG2205	protein histidine kinase activity
AL038_RS12955	COG0543	2 iron, 2 sulfur cluster binding
AL038_RS12955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL038_RS12970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL038_RS12980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL038_RS12985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL038_RS12990	COG0804	urea catabolic process
AL038_RS12995	COG0832	Belongs to the urease beta subunit family
AL038_RS13000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL038_RS13000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL038_RS13015	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL038_RS13025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL038_RS13060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AL038_RS13065	COG1040	competence protein
AL038_RS13090	COG5002	protein histidine kinase activity
AL038_RS13115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL038_RS13120	COG0312	modulator of DNA gyrase
AL038_RS13135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL038_RS13140	COG3977	Valine--pyruvate aminotransferase
AL038_RS13160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL038_RS13165	COG0795	lipopolysaccharide-transporting ATPase activity
AL038_RS13175	COG1185	polyribonucleotide nucleotidyltransferase activity
AL038_RS13180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL038_RS13195	COG0758	DNA mediated transformation
AL038_RS13200	COG2922	Belongs to the Smg family
AL038_RS13215	COG0367	asparagine synthase
AL038_RS13220	COG0438	transferase activity, transferring glycosyl groups
AL038_RS13225	COG3842	ATPase activity
AL038_RS13230	COG0745	RESPONSE REGULATOR receiver
AL038_RS13235	COG2205	protein histidine kinase activity
AL038_RS13250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL038_RS13265	COG0300	oxidoreductase activity
AL038_RS13275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL038_RS13285	COG2308	Evidence 4 Homologs of previously reported genes of
AL038_RS13285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AL038_RS13320	COG2304	oxidoreductase activity
AL038_RS13345	COG3540	Alkaline phosphatase
AL038_RS13350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL038_RS13355	COG0509	glycine decarboxylation via glycine cleavage system
AL038_RS13360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL038_RS13370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL038_RS13370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL038_RS13375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL038_RS13380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL038_RS13395	COG1662	PFAM IS1 transposase
AL038_RS13405	COG2831	hemolysin activation secretion protein
AL038_RS13415	COG0009	L-threonylcarbamoyladenylate synthase
AL038_RS13420	COG1994	Peptidase M50
AL038_RS13425	COG0439	Biotin carboxylase
AL038_RS13430	COG0511	ligase activity, forming carbon-carbon bonds
AL038_RS13435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL038_RS13440	COG0515	serine threonine protein kinase
AL038_RS13440	COG2815	serine threonine protein kinase
AL038_RS13455	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL038_RS13460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL038_RS13465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL038_RS13475	COG2274	protein secretion by the type I secretion system
AL038_RS13490	COG4166	transmembrane transport
AL038_RS13505	COG0737	Belongs to the 5'-nucleotidase family
AL038_RS13510	COG2205	protein histidine kinase activity
AL038_RS13525	COG0519	Catalyzes the synthesis of GMP from XMP
AL038_RS13525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL038_RS13535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL038_RS13560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL038_RS13565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL038_RS13590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL038_RS13595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL038_RS13605	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL038_RS13620	COG0859	PFAM glycosyl transferase family 9
AL038_RS13630	COG2201	protein-glutamate methylesterase activity
AL038_RS13635	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AL038_RS13685	COG3038	cytochrome b561
AL038_RS13700	COG0557	exoribonuclease II activity
AL038_RS13710	COG1450	Type ii and iii secretion system protein
AL038_RS13715	COG1459	type II secretion system
AL038_RS13720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL038_RS13730	COG2369	cell adhesion
AL038_RS13735	COG0525	valine-tRNA ligase activity
AL038_RS13740	COG0183	Belongs to the thiolase family
AL038_RS13750	COG0205	6-phosphofructokinase activity
AL038_RS13765	COG0193	aminoacyl-tRNA hydrolase activity
AL038_RS13770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL038_RS13775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL038_RS13785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL038_RS13790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL038_RS13800	COG2814	Major facilitator Superfamily
AL038_RS13805	COG0203	ribosomal protein L17
AL038_RS13810	COG0202	RNA polymerase activity
AL038_RS13815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL038_RS13820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL038_RS13825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL038_RS13830	COG0201	protein transport
AL038_RS13835	COG0200	Binds to the 23S rRNA
AL038_RS13840	COG1841	ribosomal large subunit assembly
AL038_RS13850	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL038_RS13855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL038_RS13865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL038_RS13870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL038_RS13875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL038_RS13880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL038_RS13885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL038_RS13900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL038_RS13910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL038_RS13915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL038_RS13920	COG0089	rRNA binding
AL038_RS13925	COG0088	Forms part of the polypeptide exit tunnel
AL038_RS13930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL038_RS13935	COG0051	transcription antitermination factor activity, RNA binding
AL038_RS13940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL038_RS13945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL038_RS13950	COG0049	tRNA binding
AL038_RS13955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL038_RS13960	COG4206	TonB-dependent receptor
AL038_RS13970	COG0612	Peptidase, M16
AL038_RS13975	COG0612	Peptidase, M16
AL038_RS13995	COG3956	TIGRFAM MazG family protein
AL038_RS14010	COG0784	Response regulator, receiver
AL038_RS14010	COG2198	Histidine kinase
AL038_RS14010	COG2205	protein histidine kinase activity
AL038_RS14030	COG1858	cytochrome C peroxidase
AL038_RS14040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL038_RS14045	COG3162	membrane
AL038_RS14050	COG0629	single-stranded DNA binding
AL038_RS14055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL038_RS14055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL038_RS14060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL038_RS14065	COG0830	nickel cation binding
AL038_RS14070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL038_RS14090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL038_RS14120	COG2814	Major facilitator Superfamily
AL038_RS14145	COG0116	Belongs to the methyltransferase superfamily
AL038_RS14145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL038_RS14150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL038_RS14155	COG0729	surface antigen
AL038_RS14165	COG1074	ATP-dependent DNA helicase activity
AL038_RS14170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL038_RS14175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AL038_RS14185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL038_RS14190	COG1160	GTP binding
AL038_RS14200	COG0604	alcohol dehydrogenase
AL038_RS14225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL038_RS14230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL038_RS14235	COG0271	Belongs to the BolA IbaG family
AL038_RS14260	COG0438	transferase activity, transferring glycosyl groups
AL038_RS14260	COG1216	Glycosyl transferase, family 2
AL038_RS14280	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AL038_RS14285	COG5002	protein histidine kinase activity
AL038_RS14295	COG4536	flavin adenine dinucleotide binding
AL038_RS14300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL038_RS14305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL038_RS14330	COG0651	ATP synthesis coupled electron transport
AL038_RS14350	COG2204	response regulator
AL038_RS14360	COG4770	biotin carboxylase activity
AL038_RS14365	COG0306	phosphate transporter
AL038_RS14385	COG3293	Transposase
AL038_RS14405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AL038_RS14415	COG0776	regulation of translation
AL038_RS14420	COG0072	phenylalanine-tRNA ligase activity
AL038_RS14430	COG0284	orotidine-5'-phosphate decarboxylase activity
AL038_RS14435	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL038_RS14445	COG0776	regulation of translation
AL038_RS14455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL038_RS14460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL038_RS14465	COG0287	Prephenate dehydrogenase
AL038_RS14470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL038_RS14475	COG2226	methyltransferase
AL038_RS14480	COG0037	tRNA processing
AL038_RS14485	COG1534	Rna-binding protein
AL038_RS14505	COG2239	Acts as a magnesium transporter
AL038_RS14530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL038_RS14530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL038_RS14600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL038_RS14610	COG0297	glycogen (starch) synthase activity
AL038_RS14615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL038_RS14620	COG2226	methyltransferase
AL038_RS14635	COG4641	Protein conserved in bacteria
AL038_RS14635	COG1388	LysM domain
AL038_RS14650	COG0438	transferase activity, transferring glycosyl groups
AL038_RS14660	COG2226	methyltransferase
AL038_RS14670	COG3293	Transposase
AL038_RS14705	COG3293	Transposase
AL038_RS14740	COG0251	oxidation-reduction process
AL038_RS14755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AL038_RS14755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AL038_RS14755	COG1703	isobutyryl-CoA mutase activity
AL038_RS14760	COG2205	protein histidine kinase activity
AL038_RS14760	COG0784	Response regulator, receiver
AL038_RS14765	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL038_RS14790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL038_RS14800	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AL038_RS14800	COG3261	NADH dehydrogenase
AL038_RS14810	COG1490	D-aminoacyl-tRNA deacylase activity
AL038_RS14820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL038_RS14830	COG2350	Protein conserved in bacteria
AL038_RS14840	COG3088	subunit of a heme lyase
AL038_RS14845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL038_RS14850	COG3842	ATPase activity
AL038_RS14855	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL038_RS14860	COG4149	molybdate abc transporter
AL038_RS14880	COG5001	Diguanylate cyclase
AL038_RS14905	COG0028	Belongs to the TPP enzyme family
AL038_RS14915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL038_RS14920	COG1183	phosphatidylcholine synthase activity
AL038_RS14940	COG2010	Cytochrome c
AL038_RS15010	COG0489	protein tyrosine kinase activity
AL038_RS15020	COG0424	maF-like protein
AL038_RS15025	COG1399	metal-binding, possibly nucleic acid-binding protein
AL038_RS15030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL038_RS15035	COG0416	fatty acid biosynthetic process
AL038_RS15040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL038_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS15055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL038_RS15060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL038_RS15070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL038_RS15080	COG0247	lactate metabolic process
AL038_RS15085	COG1592	Rubrerythrin
AL038_RS15095	COG2915	High frequency lysogenization protein hflD homolog
AL038_RS15110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL038_RS15115	COG0131	Imidazoleglycerol-phosphate dehydratase
AL038_RS15120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL038_RS15185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL038_RS15215	COG2304	oxidoreductase activity
AL038_RS15220	COG0024	Methionine aminopeptidase
AL038_RS15225	COG0052	Belongs to the universal ribosomal protein uS2 family
AL038_RS15230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL038_RS15235	COG0528	UMP kinase activity
AL038_RS15240	COG0233	cytoplasmic translational termination
AL038_RS15245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL038_RS15255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL038_RS15260	COG0750	zinc metalloprotease
AL038_RS15265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL038_RS15275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL038_RS15280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL038_RS15285	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL038_RS15290	COG0268	Binds directly to 16S ribosomal RNA
AL038_RS15295	COG1229	Formylmethanofuran dehydrogenase subunit A
AL038_RS15300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL038_RS15310	COG2319	Wd-40 repeat
AL038_RS15310	COG5635	Nacht domain
AL038_RS15320	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL038_RS15325	COG3850	Histidine kinase
AL038_RS15325	COG3437	response regulator, receiver
AL038_RS15325	COG2205	protein histidine kinase activity
AL038_RS15325	COG4999	Histidine kinase
AL038_RS15380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL038_RS15390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AL038_RS15415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL038_RS15430	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AL038_RS15435	COG0745	RESPONSE REGULATOR receiver
AL038_RS15450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL038_RS15455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL038_RS15460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL038_RS15465	COG1120	ATPase activity
AL038_RS15510	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL038_RS15520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL038_RS15535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL038_RS15550	COG2333	competence protein COMEC
AL038_RS15550	COG0658	competence protein
AL038_RS15580	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL038_RS15585	COG0351	phosphomethylpyrimidine kinase
AL038_RS15590	COG4597	amino acid ABC transporter
AL038_RS15595	COG0765	amino acid transport
AL038_RS15605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL038_RS15610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL038_RS15625	COG2974	May be involved in recombination
AL038_RS15630	COG0598	Magnesium transport protein CorA
AL038_RS15655	COG2850	peptidyl-arginine hydroxylation
AL038_RS15665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL038_RS15670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL038_RS15675	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL038_RS15705	COG3293	Transposase
AL038_RS15710	COG0316	Belongs to the HesB IscA family
AL038_RS15730	COG0633	Ferredoxin
AL038_RS15735	COG3321	synthase
AL038_RS15735	COG0604	alcohol dehydrogenase
AL038_RS15735	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS15740	COG5001	Diguanylate cyclase
AL038_RS15740	COG4251	negative regulation of phosphorylation
AL038_RS15740	COG3706	GGDEF domain
AL038_RS15740	COG2203	Gaf domain
AL038_RS15745	COG0714	Associated with various cellular activities
AL038_RS15755	COG2304	oxidoreductase activity
AL038_RS15760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL038_RS15765	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AL038_RS15785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL038_RS15790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL038_RS15815	COG1981	membrane
AL038_RS15830	COG2105	PFAM AIG2 family protein
AL038_RS15905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL038_RS15945	COG0194	GDP metabolic process
AL038_RS15950	COG1561	YicC-like family, N-terminal region
AL038_RS15955	COG1477	protein flavinylation
AL038_RS15975	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL038_RS15985	COG0181	hydroxymethylbilane synthase activity
AL038_RS15995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL038_RS16025	COG0642	Histidine kinase
AL038_RS16040	COG1459	type II secretion system
AL038_RS16045	COG0492	ferredoxin-NADP+ reductase activity
AL038_RS16050	COG1674	ftsk spoiiie
AL038_RS16090	COG3293	Transposase
AL038_RS16130	COG1662	PFAM IS1 transposase
AL038_RS16135	COG1662	PFAM IS1 transposase
AL038_RS16150	COG2202	Pas domain
AL038_RS16150	COG2205	protein histidine kinase activity
AL038_RS16155	COG5001	Diguanylate cyclase
AL038_RS16155	COG3300	MHYT domain
AL038_RS16160	COG2208	phosphoserine phosphatase activity
AL038_RS16160	COG2770	Histidine kinase
AL038_RS16170	COG0493	'glutamate synthase
AL038_RS16170	COG0543	2 iron, 2 sulfur cluster binding
AL038_RS16180	COG4651	solute:proton antiporter activity
AL038_RS16180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL038_RS16205	COG1830	Aldolase
AL038_RS16210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL038_RS16215	COG1662	PFAM IS1 transposase
AL038_RS16225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS16225	COG4191	Histidine kinase
AL038_RS16230	COG1278	Cold shock
AL038_RS16235	COG1278	Cold shock
AL038_RS16240	COG1278	Cold shock
AL038_RS16245	COG1278	Cold shock
AL038_RS16250	COG1278	Cold shock
AL038_RS16255	COG1278	Cold shock
AL038_RS16260	COG1278	Cold shock
AL038_RS16280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL038_RS16290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL038_RS16295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL038_RS16325	COG0714	Associated with various cellular activities
AL038_RS16345	COG1366	Belongs to the anti-sigma-factor antagonist family
AL038_RS16365	COG0045	succinate-CoA ligase (ADP-forming) activity
AL038_RS16370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL038_RS16375	COG0347	Belongs to the P(II) protein family
AL038_RS16380	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL038_RS16410	COG4969	Belongs to the N-Me-Phe pilin family
AL038_RS16445	COG0426	domain, Protein
AL038_RS16450	COG0633	Ferredoxin
AL038_RS16455	COG0633	Ferredoxin
AL038_RS16480	COG0542	response to heat
AL038_RS16500	COG0651	ATP synthesis coupled electron transport
AL038_RS16505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL038_RS16515	COG0779	Required for maturation of 30S ribosomal subunits
AL038_RS16520	COG0195	Participates in both transcription termination and antitermination
AL038_RS16525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL038_RS16530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL038_RS16535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL038_RS16540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL038_RS16555	COG5002	protein histidine kinase activity
AL038_RS16555	COG0784	Response regulator, receiver
AL038_RS16555	COG2205	protein histidine kinase activity
AL038_RS16580	COG2815	serine threonine protein kinase
AL038_RS16580	COG0515	serine threonine protein kinase
AL038_RS16590	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL038_RS16600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL038_RS16605	COG2267	carboxylic ester hydrolase activity
AL038_RS16630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL038_RS16635	COG1666	GTP binding
AL038_RS16640	COG0335	large ribosomal subunit rRNA binding
AL038_RS16650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL038_RS16665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AL038_RS16705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL038_RS16725	COG0175	sulfate reduction
AL038_RS16735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL038_RS16735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL038_RS16740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL038_RS16745	COG0501	Belongs to the peptidase M48B family
AL038_RS16765	COG1662	PFAM IS1 transposase
AL038_RS16805	COG0831	urea catabolic process
AL038_RS16815	COG0811	peptide transport
AL038_RS16820	COG0848	biopolymer transport protein
AL038_RS16825	COG1663	tetraacyldisaccharide 4'-kinase activity
AL038_RS16830	COG2835	tetraacyldisaccharide 4'-kinase activity
AL038_RS16835	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL038_RS16870	COG4239	(ABC) transporter, permease
AL038_RS16875	COG4174	ABC transporter (Permease)
AL038_RS16880	COG1331	Highly conserved protein containing a thioredoxin domain
AL038_RS16885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL038_RS16900	COG0459	protein refolding
AL038_RS16905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL038_RS16910	COG0501	Belongs to the peptidase M48B family
AL038_RS16925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL038_RS16945	COG4206	TonB-dependent receptor
AL038_RS16950	COG0668	transmembrane transport
AL038_RS16975	COG0772	Belongs to the SEDS family
AL038_RS17025	COG0735	belongs to the Fur family
AL038_RS17060	COG1872	DUF167
AL038_RS17085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL038_RS17090	COG1702	phosphate starvation-inducible protein PhoH
AL038_RS17100	COG4535	Mg2 and Co2 transporter CorC
AL038_RS17135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL038_RS17145	COG0714	Associated with various cellular activities
AL038_RS17150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL038_RS17195	COG2917	probably involved in intracellular septation
AL038_RS17200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL038_RS17210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL038_RS17225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL038_RS17260	COG0515	serine threonine protein kinase
AL038_RS17260	COG2815	serine threonine protein kinase
AL038_RS17270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL038_RS17280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL038_RS17285	COG0308	aminopeptidase N
AL038_RS17305	COG2198	Histidine kinase
AL038_RS17305	COG0784	Response regulator, receiver
AL038_RS17305	COG2205	protein histidine kinase activity
AL038_RS17305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS17320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL038_RS17335	COG0495	leucyl-tRNA aminoacylation
AL038_RS17350	COG0741	lytic transglycosylase activity
AL038_RS17365	COG1678	Uncharacterized ACR, COG1678
AL038_RS17370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL038_RS17375	COG0540	Belongs to the ATCase OTCase family
AL038_RS17380	COG1509	lysine 2,3-aminomutase activity
AL038_RS17385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL038_RS17390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL038_RS17395	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL038_RS17400	COG0784	Response regulator, receiver
AL038_RS17400	COG5002	protein histidine kinase activity
AL038_RS17400	COG2205	protein histidine kinase activity
AL038_RS17445	COG3260	NADH ubiquinone oxidoreductase 20
AL038_RS17470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL038_RS17470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL038_RS17505	COG0137	argininosuccinate synthase activity
AL038_RS17535	COG1595	DNA-templated transcription, initiation
AL038_RS17555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL038_RS17555	COG2205	protein histidine kinase activity
AL038_RS17560	COG1446	asparaginase
AL038_RS17565	COG0154	amidase activity
AL038_RS17575	COG1077	Cell shape determining protein MreB Mrl
AL038_RS17580	COG1792	Involved in formation and maintenance of cell shape
AL038_RS17585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL038_RS17590	COG0754	glutathionylspermidine amidase activity
AL038_RS17610	COG1028	Short-chain dehydrogenase reductase Sdr
AL038_RS17645	COG2204	response regulator
AL038_RS17650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL038_RS17655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL038_RS17665	COG0631	protein serine/threonine phosphatase activity
AL038_RS17675	COG4215	(ABC) transporter
AL038_RS17685	COG0424	maF-like protein
AL038_RS17690	COG0436	Aminotransferase
AL038_RS17715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL038_RS17720	COG0326	Molecular chaperone. Has ATPase activity
AL038_RS17735	COG2258	MOSC domain
AL038_RS17740	COG0134	indole-3-glycerol-phosphate synthase activity
AL038_RS17770	COG2205	protein histidine kinase activity
AL038_RS17775	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL038_RS17795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL038_RS17810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL038_RS17835	COG0058	SHG alpha-glucan phosphorylase activity
AL038_RS17855	COG2224	Isocitrate lyase
AL038_RS17860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL038_RS17870	COG0583	DNA-binding transcription factor activity
AL038_RS17880	COG0585	pseudouridine synthase activity
AL038_RS17885	COG0628	permease
AL038_RS17895	COG4771	TonB-dependent receptor
AL038_RS17900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL038_RS17905	COG2208	phosphoserine phosphatase activity
AL038_RS17905	COG2770	Histidine kinase
AL038_RS17910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL038_RS17915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL038_RS17935	COG0174	glutamine synthetase
AL038_RS17940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL038_RS17955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL038_RS17970	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AL038_RS18025	COG2079	MmgE PrpD family protein
AL038_RS18030	COG0372	Belongs to the citrate synthase family
AL038_RS18035	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL038_RS18055	COG0714	Associated with various cellular activities
AL038_RS18060	COG5002	protein histidine kinase activity
AL038_RS18060	COG5001	Diguanylate cyclase
AL038_RS18065	COG3842	ATPase activity
AL038_RS18070	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL038_RS18075	COG1177	transmembrane transport
AL038_RS18110	COG0517	IMP dehydrogenase activity
AL038_RS18110	COG0516	GMP reductase activity
AL038_RS18125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL038_RS18135	COG4974	Belongs to the 'phage' integrase family