locus-tag	class	description
BLE401_RS00025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BLE401_RS00080	COG0138	bifunctional purine biosynthesis protein purh
BLE401_RS00085	COG0151	Belongs to the GarS family
BLE401_RS00100	COG0277	FAD linked oxidase domain protein
BLE401_RS00105	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BLE401_RS00105	COG0546	phosphoglycolate phosphatase activity
BLE401_RS00165	COG4942	peptidase
BLE401_RS00170	COG0793	Belongs to the peptidase S41A family
BLE401_RS00180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BLE401_RS00210	COG0488	(ABC) transporter
BLE401_RS00250	COG2192	nodulation
BLE401_RS00260	COG2192	nodulation
BLE401_RS00290	COG1472	Belongs to the glycosyl hydrolase 3 family
BLE401_RS00310	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BLE401_RS00330	COG1918	ferrous iron import across plasma membrane
BLE401_RS00360	COG2217	Heavy metal translocating P-type atpase
BLE401_RS00365	COG0252	asparaginase activity
BLE401_RS00370	COG5002	protein histidine kinase activity
BLE401_RS00370	COG0784	Response regulator, receiver
BLE401_RS00375	COG0641	radical SAM
BLE401_RS00380	COG0864	Transcriptional regulator
BLE401_RS00390	COG1643	Atp-dependent helicase
BLE401_RS00405	COG3116	cell division
BLE401_RS00415	COG0519	Catalyzes the synthesis of GMP from XMP
BLE401_RS00420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BLE401_RS00425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BLE401_RS00430	COG0494	nUDIX hydrolase
BLE401_RS00440	COG2943	transferase activity, transferring hexosyl groups
BLE401_RS00445	COG2176	DNA-directed DNA polymerase activity
BLE401_RS00460	COG2009	succinate dehydrogenase
BLE401_RS00465	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BLE401_RS00470	COG1053	succinate dehydrogenase
BLE401_RS00475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BLE401_RS00505	COG0187	DNA topoisomerase II activity
BLE401_RS00525	COG1131	(ABC) transporter
BLE401_RS00535	COG0339	signal peptide processing
BLE401_RS00540	COG0463	Glycosyl transferase, family 2
BLE401_RS00545	COG0697	spore germination
BLE401_RS00560	COG0464	growth
BLE401_RS00565	COG1942	4-Oxalocrotonate Tautomerase
BLE401_RS00570	COG2205	protein histidine kinase activity
BLE401_RS00570	COG0784	Response regulator, receiver
BLE401_RS00625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BLE401_RS00640	COG2205	protein histidine kinase activity
BLE401_RS00640	COG2198	Histidine kinase
BLE401_RS00640	COG0784	Response regulator, receiver
BLE401_RS00645	COG0420	3'-5' exonuclease activity
BLE401_RS00670	COG2995	paraquat-inducible protein a
BLE401_RS00675	COG3008	intermembrane lipid transfer
BLE401_RS00705	COG0247	lactate metabolic process
BLE401_RS00710	COG0277	FAD linked oxidase domain protein
BLE401_RS00715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BLE401_RS00775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BLE401_RS00785	COG3706	GGDEF domain
BLE401_RS00790	COG3437	response regulator, receiver
BLE401_RS00790	COG2205	protein histidine kinase activity
BLE401_RS00790	COG4999	Histidine kinase
BLE401_RS00790	COG3850	Histidine kinase
BLE401_RS00795	COG2050	protein possibly involved in aromatic compounds catabolism
BLE401_RS00800	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BLE401_RS00815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BLE401_RS00835	COG3437	response regulator, receiver
BLE401_RS00835	COG3850	Histidine kinase
BLE401_RS00835	COG4999	Histidine kinase
BLE401_RS00835	COG2205	protein histidine kinase activity
BLE401_RS00840	COG4999	Histidine kinase
BLE401_RS00840	COG3850	Histidine kinase
BLE401_RS00840	COG3437	response regulator, receiver
BLE401_RS00840	COG2205	protein histidine kinase activity
BLE401_RS00845	COG4999	Histidine kinase
BLE401_RS00845	COG3850	Histidine kinase
BLE401_RS00845	COG3437	response regulator, receiver
BLE401_RS00845	COG2205	protein histidine kinase activity
BLE401_RS00875	COG5001	Diguanylate cyclase
BLE401_RS00875	COG5002	protein histidine kinase activity
BLE401_RS00905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BLE401_RS00910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BLE401_RS00925	COG0714	Associated with various cellular activities
BLE401_RS00945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BLE401_RS00955	COG5002	protein histidine kinase activity
BLE401_RS00955	COG2176	DNA-directed DNA polymerase activity
BLE401_RS00960	COG0745	RESPONSE REGULATOR receiver
BLE401_RS00965	COG1556	Lactate utilization protein
BLE401_RS00970	COG1139	Iron-sulfur cluster binding protein
BLE401_RS00975	COG2198	Histidine kinase
BLE401_RS00975	COG2205	protein histidine kinase activity
BLE401_RS00975	COG0784	Response regulator, receiver
BLE401_RS00980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BLE401_RS00990	COG4174	ABC transporter (Permease)
BLE401_RS00995	COG0753	catalase activity
BLE401_RS01020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BLE401_RS01025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BLE401_RS01035	COG2132	Multicopper oxidase
BLE401_RS01080	COG0835	chemotaxis
BLE401_RS01085	COG0643	Histidine kinase
BLE401_RS01085	COG2198	Histidine kinase
BLE401_RS01090	COG0745	RESPONSE REGULATOR receiver
BLE401_RS01100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BLE401_RS01120	COG0442	prolyl-tRNA aminoacylation
BLE401_RS01130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BLE401_RS01130	COG1017	nitric oxide dioxygenase activity
BLE401_RS01140	COG1587	Uroporphyrinogen-III synthase
BLE401_RS01150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BLE401_RS01155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BLE401_RS01160	COG0148	phosphopyruvate hydratase activity
BLE401_RS01165	COG0285	dihydrofolate synthase activity
BLE401_RS01170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BLE401_RS01170	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BLE401_RS01180	COG1215	transferase activity, transferring glycosyl groups
BLE401_RS01195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BLE401_RS01200	COG0217	transcriptional regulatory protein
BLE401_RS01205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLE401_RS01210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BLE401_RS01215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BLE401_RS01225	COG2770	Histidine kinase
BLE401_RS01225	COG2208	phosphoserine phosphatase activity
BLE401_RS01230	COG1773	rubredoxin
BLE401_RS01250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BLE401_RS01295	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BLE401_RS01310	COG5265	(ABC) transporter
BLE401_RS01320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BLE401_RS01325	COG0386	Belongs to the glutathione peroxidase family
BLE401_RS01335	COG0587	DNA-directed DNA polymerase activity
BLE401_RS01350	COG2914	Belongs to the UPF0125 (RnfH) family
BLE401_RS01365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BLE401_RS01380	COG2205	protein histidine kinase activity
BLE401_RS01380	COG2202	Pas domain
BLE401_RS01385	COG3243	poly(R)-hydroxyalkanoic acid synthase
BLE401_RS01415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BLE401_RS01415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BLE401_RS01420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BLE401_RS01445	COG3267	Type II secretory pathway component ExeA
BLE401_RS01445	COG3409	Peptidoglycan-binding domain 1 protein
BLE401_RS01455	COG0730	response to heat
BLE401_RS01460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BLE401_RS01465	COG3604	Transcriptional regulator
BLE401_RS01470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BLE401_RS01485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BLE401_RS01485	COG3320	Male sterility
BLE401_RS01490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BLE401_RS01500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLE401_RS01505	COG4999	Histidine kinase
BLE401_RS01505	COG3850	Histidine kinase
BLE401_RS01505	COG2205	protein histidine kinase activity
BLE401_RS01505	COG3437	response regulator, receiver
BLE401_RS01510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BLE401_RS01515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BLE401_RS01525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BLE401_RS01530	COG2921	Belongs to the UPF0250 family
BLE401_RS01535	COG0357	Ribosomal RNA small subunit methyltransferase G
BLE401_RS01550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BLE401_RS01555	COG1194	a g-specific adenine glycosylase
BLE401_RS01570	COG4797	methyltransferase
BLE401_RS01570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BLE401_RS01575	COG0312	modulator of DNA gyrase
BLE401_RS01625	COG0860	N-Acetylmuramoyl-L-alanine amidase
BLE401_RS01630	COG3755	Protein conserved in bacteria
BLE401_RS01640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BLE401_RS01670	COG2197	response regulator
BLE401_RS01680	COG2205	protein histidine kinase activity
BLE401_RS01680	COG0784	Response regulator, receiver
BLE401_RS01690	COG3001	Fructosamine kinase
BLE401_RS01705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BLE401_RS01710	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BLE401_RS01710	COG0662	Cupin 2, conserved barrel domain protein
BLE401_RS01715	COG5002	protein histidine kinase activity
BLE401_RS01715	COG2176	DNA-directed DNA polymerase activity
BLE401_RS01730	COG2208	phosphoserine phosphatase activity
BLE401_RS01730	COG2770	Histidine kinase
BLE401_RS01735	COG0583	DNA-binding transcription factor activity
BLE401_RS01745	COG3025	triphosphatase activity
BLE401_RS01780	COG3218	ABC-type transport auxiliary lipoprotein component
BLE401_RS01815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BLE401_RS01835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BLE401_RS01850	COG5002	protein histidine kinase activity
BLE401_RS01850	COG2198	Histidine kinase
BLE401_RS01850	COG0784	Response regulator, receiver
BLE401_RS01870	COG0546	phosphoglycolate phosphatase activity
BLE401_RS01880	COG0215	cysteine-tRNA ligase activity
BLE401_RS01890	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BLE401_RS01900	COG0784	Response regulator, receiver
BLE401_RS01900	COG5002	protein histidine kinase activity
BLE401_RS01900	COG2205	protein histidine kinase activity
BLE401_RS01915	COG1116	anion transmembrane transporter activity
BLE401_RS01945	COG1842	Phage shock protein A
BLE401_RS01955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BLE401_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS01980	COG0737	Belongs to the 5'-nucleotidase family
BLE401_RS01985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BLE401_RS01995	COG0560	Phosphoserine phosphatase
BLE401_RS02000	COG0037	tRNA processing
BLE401_RS02005	COG0330	HflC and HflK could
BLE401_RS02025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BLE401_RS02050	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BLE401_RS02050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BLE401_RS02055	COG0745	RESPONSE REGULATOR receiver
BLE401_RS02070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BLE401_RS02075	COG1469	GTP cyclohydrolase I activity
BLE401_RS02100	COG0312	modulator of DNA gyrase
BLE401_RS02110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS02115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BLE401_RS02125	COG3706	GGDEF domain
BLE401_RS02125	COG4251	negative regulation of phosphorylation
BLE401_RS02125	COG2203	Gaf domain
BLE401_RS02125	COG5001	Diguanylate cyclase
BLE401_RS02135	COG0418	dihydroorotase activity
BLE401_RS02140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BLE401_RS02160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BLE401_RS02165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BLE401_RS02180	COG1022	Amp-dependent synthetase and ligase
BLE401_RS02185	COG0006	proline dipeptidase activity
BLE401_RS02195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLE401_RS02200	COG1758	RNA polymerase activity
BLE401_RS02260	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BLE401_RS02275	COG1459	type II secretion system
BLE401_RS02285	COG2862	Uncharacterized protein family, UPF0114
BLE401_RS02300	COG1597	lipid kinase activity
BLE401_RS02320	COG4660	Part of a membrane complex involved in electron transport
BLE401_RS02325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BLE401_RS02330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BLE401_RS02340	COG4657	Part of a membrane complex involved in electron transport
BLE401_RS02345	COG2878	Part of a membrane complex involved in electron transport
BLE401_RS02350	COG4656	Part of a membrane complex involved in electron transport
BLE401_RS02355	COG4658	electron transport chain
BLE401_RS02370	COG2914	Belongs to the UPF0125 (RnfH) family
BLE401_RS02390	COG0735	belongs to the Fur family
BLE401_RS02410	COG2918	glutathione biosynthetic process
BLE401_RS02415	COG0067	glutamate synthase
BLE401_RS02415	COG0069	glutamate synthase activity
BLE401_RS02415	COG0070	glutamate synthase
BLE401_RS02420	COG0493	'glutamate synthase
BLE401_RS02430	COG0298	carbon dioxide binding
BLE401_RS02435	COG0375	protein maturation
BLE401_RS02440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS02440	COG2205	protein histidine kinase activity
BLE401_RS02465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BLE401_RS02470	COG0321	lipoyl(octanoyl) transferase activity
BLE401_RS02500	COG1129	ABC transporter
BLE401_RS02520	COG4133	protoheme IX ABC transporter activity
BLE401_RS02525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BLE401_RS02530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BLE401_RS02570	COG1858	cytochrome C peroxidase
BLE401_RS02590	COG3243	poly(R)-hydroxyalkanoic acid synthase
BLE401_RS02640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BLE401_RS02645	COG0183	Belongs to the thiolase family
BLE401_RS02655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BLE401_RS02660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BLE401_RS02665	COG1765	OsmC-like protein
BLE401_RS02670	COG0360	Binds together with S18 to 16S ribosomal RNA
BLE401_RS02675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BLE401_RS02680	COG0359	binds to the 23S rRNA
BLE401_RS02690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BLE401_RS02710	COG0508	dehydrogenase complex catalyzes the overall conversion of
BLE401_RS02725	COG0322	excinuclease ABC activity
BLE401_RS02750	COG1166	arginine decarboxylase activity
BLE401_RS02765	COG2885	chlorophyll binding
BLE401_RS02785	COG0784	Response regulator, receiver
BLE401_RS02785	COG5002	protein histidine kinase activity
BLE401_RS02785	COG2205	protein histidine kinase activity
BLE401_RS02790	COG0741	lytic transglycosylase activity
BLE401_RS02825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BLE401_RS02830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BLE401_RS02845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BLE401_RS02850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BLE401_RS02855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BLE401_RS02865	COG0792	nuclease activity
BLE401_RS02890	COG0837	glucose binding
BLE401_RS02915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BLE401_RS02920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLE401_RS02920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLE401_RS02930	COG3954	Phosphoribulokinase
BLE401_RS02935	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BLE401_RS02940	COG0840	transmembrane signaling receptor activity
BLE401_RS02955	COG0584	glycerophosphoryl diester phosphodiesterase
BLE401_RS02970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BLE401_RS02980	COG5002	protein histidine kinase activity
BLE401_RS02980	COG2198	Histidine kinase
BLE401_RS02980	COG0784	Response regulator, receiver
BLE401_RS03000	COG0840	transmembrane signaling receptor activity
BLE401_RS03005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS03040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS03055	COG0303	'Molybdopterin
BLE401_RS03070	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BLE401_RS03080	COG0069	glutamate synthase activity
BLE401_RS03100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BLE401_RS03105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BLE401_RS03160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLE401_RS03180	COG3597	protein domain associated with
BLE401_RS03200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BLE401_RS03205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BLE401_RS03210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BLE401_RS03215	COG0149	triose-phosphate isomerase activity
BLE401_RS03220	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BLE401_RS03245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BLE401_RS03255	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BLE401_RS03265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BLE401_RS03270	COG2373	Large extracellular alpha-helical protein
BLE401_RS03275	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BLE401_RS03280	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BLE401_RS03285	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BLE401_RS03300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BLE401_RS03305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BLE401_RS03310	COG0505	Belongs to the CarA family
BLE401_RS03320	COG0165	Argininosuccinate lyase
BLE401_RS03325	COG2030	dehydratase
BLE401_RS03345	COG0784	Response regulator, receiver
BLE401_RS03345	COG2205	protein histidine kinase activity
BLE401_RS03350	COG0527	aspartate kinase activity
BLE401_RS03355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BLE401_RS03380	COG0402	S-adenosylhomocysteine deaminase activity
BLE401_RS03385	COG0484	heat shock protein binding
BLE401_RS03405	COG4942	peptidase
BLE401_RS03410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BLE401_RS03425	COG1051	belongs to the nudix hydrolase family
BLE401_RS03430	COG1570	exodeoxyribonuclease VII activity
BLE401_RS03440	COG0071	Belongs to the small heat shock protein (HSP20) family
BLE401_RS03460	COG2906	2 iron, 2 sulfur cluster binding
BLE401_RS03470	COG0784	Response regulator, receiver
BLE401_RS03470	COG2205	protein histidine kinase activity
BLE401_RS03480	COG3240	lipase activity
BLE401_RS03485	COG0604	alcohol dehydrogenase
BLE401_RS03495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BLE401_RS03505	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS03515	COG0446	pyridine nucleotide-disulphide oxidoreductase
BLE401_RS03520	COG2226	methyltransferase
BLE401_RS03525	COG2967	ApaG domain
BLE401_RS03530	COG0500	methyltransferase
BLE401_RS03550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BLE401_RS03590	COG1598	PFAM Uncharacterised protein family UPF0150
BLE401_RS03655	COG1598	PFAM Uncharacterised protein family UPF0150
BLE401_RS03685	COG0582	viral genome integration into host DNA
BLE401_RS03695	COG0142	geranyltranstransferase activity
BLE401_RS03700	COG2363	Small membrane protein
BLE401_RS03705	COG2204	response regulator
BLE401_RS03735	COG1960	acyl-CoA dehydrogenase activity
BLE401_RS03740	COG1960	acyl-CoA dehydrogenase activity
BLE401_RS03745	COG0133	tryptophan synthase activity
BLE401_RS03750	COG0159	tryptophan synthase activity
BLE401_RS03755	COG2885	chlorophyll binding
BLE401_RS03775	COG0742	ribosomal rna small subunit methyltransferase
BLE401_RS03785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BLE401_RS03790	COG3267	Type II secretory pathway component ExeA
BLE401_RS03790	COG3409	Peptidoglycan-binding domain 1 protein
BLE401_RS03825	COG0475	glutathione-regulated potassium exporter activity
BLE401_RS03850	COG0784	Response regulator, receiver
BLE401_RS03850	COG2205	protein histidine kinase activity
BLE401_RS03860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BLE401_RS03865	COG3311	Transcriptional regulator
BLE401_RS03875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BLE401_RS03880	COG0436	Aminotransferase
BLE401_RS03895	COG5001	Diguanylate cyclase
BLE401_RS03895	COG5002	protein histidine kinase activity
BLE401_RS03905	COG0310	cobalt ion transport
BLE401_RS03910	COG0310	cobalt ion transport
BLE401_RS03930	COG1126	abc transporter atp-binding protein
BLE401_RS03960	COG3850	Histidine kinase
BLE401_RS03970	COG0123	including yeast histone deacetylase and acetoin utilization protein
BLE401_RS03980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BLE401_RS03985	COG2119	membrane
BLE401_RS03990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLE401_RS04000	COG2096	Adenosyltransferase
BLE401_RS04015	COG0529	Catalyzes the synthesis of activated sulfate
BLE401_RS04020	COG0142	geranyltranstransferase activity
BLE401_RS04025	COG2884	Cell division ATP-binding protein ftsE
BLE401_RS04035	COG3391	amine dehydrogenase activity
BLE401_RS04060	COG3852	Histidine kinase
BLE401_RS04065	COG2205	protein histidine kinase activity
BLE401_RS04065	COG0784	Response regulator, receiver
BLE401_RS04065	COG5002	protein histidine kinase activity
BLE401_RS04070	COG0488	(ABC) transporter
BLE401_RS04085	COG2192	nodulation
BLE401_RS04100	COG0747	negative chemotaxis
BLE401_RS04125	COG2239	Acts as a magnesium transporter
BLE401_RS04155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BLE401_RS04160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BLE401_RS04165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BLE401_RS04175	COG1132	(ABC) transporter
BLE401_RS04180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BLE401_RS04195	COG0741	lytic transglycosylase activity
BLE401_RS04225	COG1773	rubredoxin
BLE401_RS04230	COG0189	ligase activity
BLE401_RS04245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLE401_RS04255	COG0481	GTPase activity
BLE401_RS04275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BLE401_RS04295	COG2205	protein histidine kinase activity
BLE401_RS04295	COG0784	Response regulator, receiver
BLE401_RS04305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BLE401_RS04310	COG0784	Response regulator, receiver
BLE401_RS04310	COG5002	protein histidine kinase activity
BLE401_RS04310	COG2198	Histidine kinase
BLE401_RS04320	COG3243	poly(R)-hydroxyalkanoic acid synthase
BLE401_RS04325	COG4172	Belongs to the ABC transporter superfamily
BLE401_RS04335	COG0784	Response regulator, receiver
BLE401_RS04335	COG2205	protein histidine kinase activity
BLE401_RS04335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS04335	COG2198	Histidine kinase
BLE401_RS04350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS04355	COG1131	(ABC) transporter
BLE401_RS04360	COG0842	Transport permease protein
BLE401_RS04375	COG0840	transmembrane signaling receptor activity
BLE401_RS04395	COG2226	methyltransferase
BLE401_RS04405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS04405	COG2205	protein histidine kinase activity
BLE401_RS04425	COG0259	pyridoxamine-phosphate oxidase activity
BLE401_RS04430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BLE401_RS04445	COG0546	phosphoglycolate phosphatase activity
BLE401_RS04450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BLE401_RS04465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BLE401_RS04470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BLE401_RS04485	COG3264	Mechanosensitive ion channel
BLE401_RS04485	COG1196	nuclear chromosome segregation
BLE401_RS04540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BLE401_RS04580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLE401_RS04585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BLE401_RS04590	COG2949	membrane
BLE401_RS04620	COG4999	Histidine kinase
BLE401_RS04620	COG3437	response regulator, receiver
BLE401_RS04620	COG3850	Histidine kinase
BLE401_RS04620	COG2205	protein histidine kinase activity
BLE401_RS04695	COG4569	acetaldehyde dehydrogenase (acetylating) activity
BLE401_RS04700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BLE401_RS04755	COG0445	tRNA wobble uridine modification
BLE401_RS04815	COG0577	efflux transmembrane transporter activity
BLE401_RS04815	COG1136	(ABC) transporter
BLE401_RS04820	COG1136	(ABC) transporter
BLE401_RS04855	COG0802	atpase or kinase
BLE401_RS04860	COG0730	response to heat
BLE401_RS04890	COG4999	Histidine kinase
BLE401_RS04890	COG3437	response regulator, receiver
BLE401_RS04890	COG2205	protein histidine kinase activity
BLE401_RS04890	COG3850	Histidine kinase
BLE401_RS04895	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BLE401_RS04945	COG3108	Peptidase M15
BLE401_RS04950	COG2989	Protein conserved in bacteria
BLE401_RS04965	COG0745	RESPONSE REGULATOR receiver
BLE401_RS04980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BLE401_RS04990	COG1368	sulfuric ester hydrolase activity
BLE401_RS05000	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
BLE401_RS05015	COG0702	epimerase
BLE401_RS05020	COG0736	holo-[acyl-carrier-protein] synthase activity
BLE401_RS05050	COG0521	Mo-molybdopterin cofactor biosynthetic process
BLE401_RS05065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BLE401_RS05070	COG0798	PFAM Bile acid sodium symporter
BLE401_RS05075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BLE401_RS05080	COG1216	Glycosyl transferase, family 2
BLE401_RS05080	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS05100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BLE401_RS05105	COG0594	ribonuclease P activity
BLE401_RS05110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BLE401_RS05115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BLE401_RS05130	COG0508	dehydrogenase complex catalyzes the overall conversion of
BLE401_RS05165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BLE401_RS05185	COG4249	Peptidase C14 caspase catalytic subunit p20
BLE401_RS05185	COG2319	Wd-40 repeat
BLE401_RS05200	COG4659	FMN binding
BLE401_RS05205	COG4658	electron transport chain
BLE401_RS05220	COG4656	Part of a membrane complex involved in electron transport
BLE401_RS05225	COG2878	Part of a membrane complex involved in electron transport
BLE401_RS05255	COG1355	regulation of microtubule-based process
BLE401_RS05260	COG3885	ferrous iron binding
BLE401_RS05260	COG2078	PFAM AMMECR1 domain protein
BLE401_RS05270	COG1923	regulation of RNA biosynthetic process
BLE401_RS05280	COG4774	siderophore transport
BLE401_RS05285	COG3128	pkhd-type hydroxylase
BLE401_RS05305	COG0004	ammonium transporteR
BLE401_RS05365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BLE401_RS05370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BLE401_RS05385	COG1690	Belongs to the RtcB family
BLE401_RS05420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BLE401_RS05425	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
BLE401_RS05445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BLE401_RS05460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BLE401_RS05475	COG2847	Copper chaperone PCu(A)C
BLE401_RS05480	COG0688	phosphatidylethanolamine metabolic process
BLE401_RS05485	COG0741	lytic transglycosylase activity
BLE401_RS05485	COG1388	LysM domain
BLE401_RS05490	COG4451	ribulose bisphosphate carboxylase, small
BLE401_RS05495	COG1850	ribulose-bisphosphate carboxylase activity
BLE401_RS05500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BLE401_RS05535	COG0129	dihydroxy-acid dehydratase activity
BLE401_RS05555	COG1487	ribonuclease activity
BLE401_RS05580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BLE401_RS05585	COG0653	protein targeting
BLE401_RS05595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BLE401_RS05610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BLE401_RS05615	COG1181	Belongs to the D-alanine--D-alanine ligase family
BLE401_RS05620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BLE401_RS05630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BLE401_RS05685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BLE401_RS05685	COG0519	Catalyzes the synthesis of GMP from XMP
BLE401_RS05695	COG4251	negative regulation of phosphorylation
BLE401_RS05695	COG2203	Gaf domain
BLE401_RS05695	COG3706	GGDEF domain
BLE401_RS05695	COG5001	Diguanylate cyclase
BLE401_RS05720	COG0316	Belongs to the HesB IscA family
BLE401_RS05725	COG0728	peptidoglycan biosynthetic process
BLE401_RS05730	COG0196	riboflavin kinase activity
BLE401_RS05740	COG1196	nuclear chromosome segregation
BLE401_RS05760	COG0746	molybdenum cofactor guanylyltransferase activity
BLE401_RS05770	COG0315	cyclic pyranopterin monophosphate synthase activity
BLE401_RS05775	COG3034	peptidoglycan biosynthetic process
BLE401_RS05920	COG4974	Belongs to the 'phage' integrase family
BLE401_RS05925	COG2356	endonuclease I
BLE401_RS06045	COG4974	Belongs to the 'phage' integrase family
BLE401_RS06055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BLE401_RS06070	COG0516	GMP reductase activity
BLE401_RS06070	COG0517	IMP dehydrogenase activity
BLE401_RS06100	COG1177	transmembrane transport
BLE401_RS06105	COG1176	ABC-type spermidine putrescine transport system, permease component I
BLE401_RS06110	COG3842	ATPase activity
BLE401_RS06115	COG5001	Diguanylate cyclase
BLE401_RS06115	COG5002	protein histidine kinase activity
BLE401_RS06120	COG0714	Associated with various cellular activities
BLE401_RS06140	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BLE401_RS06145	COG0372	Belongs to the citrate synthase family
BLE401_RS06150	COG2079	MmgE PrpD family protein
BLE401_RS06205	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BLE401_RS06225	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BLE401_RS06240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BLE401_RS06245	COG0174	glutamine synthetase
BLE401_RS06265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BLE401_RS06270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BLE401_RS06275	COG2770	Histidine kinase
BLE401_RS06275	COG2208	phosphoserine phosphatase activity
BLE401_RS06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BLE401_RS06285	COG4771	TonB-dependent receptor
BLE401_RS06295	COG0628	permease
BLE401_RS06300	COG0585	pseudouridine synthase activity
BLE401_RS06310	COG0583	DNA-binding transcription factor activity
BLE401_RS06320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BLE401_RS06325	COG2224	Isocitrate lyase
BLE401_RS06350	COG0058	SHG alpha-glucan phosphorylase activity
BLE401_RS06375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BLE401_RS06390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BLE401_RS06410	COG2154	pterin-4-alpha-carbinolamine dehydratase
BLE401_RS06415	COG2205	protein histidine kinase activity
BLE401_RS06445	COG0134	indole-3-glycerol-phosphate synthase activity
BLE401_RS06450	COG2258	MOSC domain
BLE401_RS06465	COG0326	Molecular chaperone. Has ATPase activity
BLE401_RS06470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BLE401_RS06495	COG0436	Aminotransferase
BLE401_RS06500	COG0424	maF-like protein
BLE401_RS06510	COG4215	(ABC) transporter
BLE401_RS06520	COG0631	protein serine/threonine phosphatase activity
BLE401_RS06530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BLE401_RS06535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLE401_RS06540	COG2204	response regulator
BLE401_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS06585	COG0754	glutathionylspermidine amidase activity
BLE401_RS06590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BLE401_RS06595	COG1792	Involved in formation and maintenance of cell shape
BLE401_RS06600	COG1077	Cell shape determining protein MreB Mrl
BLE401_RS06610	COG0154	amidase activity
BLE401_RS06615	COG1446	asparaginase
BLE401_RS06620	COG2205	protein histidine kinase activity
BLE401_RS06620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS06640	COG1595	DNA-templated transcription, initiation
BLE401_RS06670	COG0137	argininosuccinate synthase activity
BLE401_RS06705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BLE401_RS06705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BLE401_RS06730	COG3260	NADH ubiquinone oxidoreductase 20
BLE401_RS06775	COG0784	Response regulator, receiver
BLE401_RS06775	COG2205	protein histidine kinase activity
BLE401_RS06775	COG5002	protein histidine kinase activity
BLE401_RS06780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BLE401_RS06785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BLE401_RS06790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BLE401_RS06795	COG1509	lysine 2,3-aminomutase activity
BLE401_RS06800	COG0540	Belongs to the ATCase OTCase family
BLE401_RS06805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BLE401_RS06810	COG1678	Uncharacterized ACR, COG1678
BLE401_RS06825	COG0741	lytic transglycosylase activity
BLE401_RS06840	COG0495	leucyl-tRNA aminoacylation
BLE401_RS06855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BLE401_RS06870	COG2205	protein histidine kinase activity
BLE401_RS06870	COG2198	Histidine kinase
BLE401_RS06870	COG0784	Response regulator, receiver
BLE401_RS06870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS06895	COG0308	aminopeptidase N
BLE401_RS06900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BLE401_RS06910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLE401_RS06920	COG2815	serine threonine protein kinase
BLE401_RS06920	COG0515	serine threonine protein kinase
BLE401_RS06955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BLE401_RS06970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BLE401_RS06980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLE401_RS06985	COG2917	probably involved in intracellular septation
BLE401_RS07000	COG1335	isochorismatase
BLE401_RS07030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BLE401_RS07040	COG0714	Associated with various cellular activities
BLE401_RS07050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BLE401_RS07085	COG4535	Mg2 and Co2 transporter CorC
BLE401_RS07095	COG1702	phosphate starvation-inducible protein PhoH
BLE401_RS07100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BLE401_RS07125	COG1872	DUF167
BLE401_RS07160	COG0735	belongs to the Fur family
BLE401_RS07215	COG0772	Belongs to the SEDS family
BLE401_RS07240	COG0668	transmembrane transport
BLE401_RS07245	COG4206	TonB-dependent receptor
BLE401_RS07265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BLE401_RS07280	COG0501	Belongs to the peptidase M48B family
BLE401_RS07285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BLE401_RS07290	COG0459	protein refolding
BLE401_RS07305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BLE401_RS07310	COG1331	Highly conserved protein containing a thioredoxin domain
BLE401_RS07315	COG4174	ABC transporter (Permease)
BLE401_RS07320	COG4239	(ABC) transporter, permease
BLE401_RS07355	COG0446	pyridine nucleotide-disulphide oxidoreductase
BLE401_RS07360	COG2835	tetraacyldisaccharide 4'-kinase activity
BLE401_RS07365	COG1663	tetraacyldisaccharide 4'-kinase activity
BLE401_RS07370	COG0848	biopolymer transport protein
BLE401_RS07375	COG0811	peptide transport
BLE401_RS07385	COG0831	urea catabolic process
BLE401_RS07440	COG0501	Belongs to the peptidase M48B family
BLE401_RS07445	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BLE401_RS07450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BLE401_RS07450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BLE401_RS07460	COG0175	sulfate reduction
BLE401_RS07480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BLE401_RS07520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BLE401_RS07535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BLE401_RS07545	COG0335	large ribosomal subunit rRNA binding
BLE401_RS07550	COG1666	GTP binding
BLE401_RS07555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BLE401_RS07580	COG2267	carboxylic ester hydrolase activity
BLE401_RS07585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BLE401_RS07595	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BLE401_RS07605	COG2815	serine threonine protein kinase
BLE401_RS07605	COG0515	serine threonine protein kinase
BLE401_RS07635	COG2205	protein histidine kinase activity
BLE401_RS07635	COG0784	Response regulator, receiver
BLE401_RS07635	COG5002	protein histidine kinase activity
BLE401_RS07650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BLE401_RS07655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BLE401_RS07660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BLE401_RS07665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BLE401_RS07670	COG0195	Participates in both transcription termination and antitermination
BLE401_RS07675	COG0779	Required for maturation of 30S ribosomal subunits
BLE401_RS07685	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BLE401_RS07690	COG0651	ATP synthesis coupled electron transport
BLE401_RS07710	COG0542	response to heat
BLE401_RS07735	COG0633	Ferredoxin
BLE401_RS07740	COG0633	Ferredoxin
BLE401_RS07745	COG0426	domain, Protein
BLE401_RS07780	COG4969	Belongs to the N-Me-Phe pilin family
BLE401_RS07810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BLE401_RS07815	COG0347	Belongs to the P(II) protein family
BLE401_RS07820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BLE401_RS07825	COG0045	succinate-CoA ligase (ADP-forming) activity
BLE401_RS07845	COG1366	Belongs to the anti-sigma-factor antagonist family
BLE401_RS07865	COG0714	Associated with various cellular activities
BLE401_RS07895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BLE401_RS07900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS07910	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BLE401_RS07930	COG1278	Cold shock
BLE401_RS07935	COG1278	Cold shock
BLE401_RS07940	COG1278	Cold shock
BLE401_RS07945	COG1278	Cold shock
BLE401_RS07950	COG1278	Cold shock
BLE401_RS07955	COG1278	Cold shock
BLE401_RS07960	COG1278	Cold shock
BLE401_RS07965	COG4191	Histidine kinase
BLE401_RS07965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS07975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BLE401_RS07980	COG1830	Aldolase
BLE401_RS08005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BLE401_RS08005	COG4651	solute:proton antiporter activity
BLE401_RS08015	COG0543	2 iron, 2 sulfur cluster binding
BLE401_RS08015	COG0493	'glutamate synthase
BLE401_RS08025	COG2770	Histidine kinase
BLE401_RS08025	COG2208	phosphoserine phosphatase activity
BLE401_RS08030	COG3300	MHYT domain
BLE401_RS08030	COG5001	Diguanylate cyclase
BLE401_RS08035	COG2205	protein histidine kinase activity
BLE401_RS08125	COG1674	ftsk spoiiie
BLE401_RS08130	COG0492	ferredoxin-NADP+ reductase activity
BLE401_RS08135	COG1459	type II secretion system
BLE401_RS08150	COG0642	Histidine kinase
BLE401_RS08185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BLE401_RS08195	COG0181	hydroxymethylbilane synthase activity
BLE401_RS08205	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BLE401_RS08225	COG1477	protein flavinylation
BLE401_RS08230	COG1561	YicC-like family, N-terminal region
BLE401_RS08235	COG0194	GDP metabolic process
BLE401_RS08275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BLE401_RS08350	COG2105	PFAM AIG2 family protein
BLE401_RS08365	COG1981	membrane
BLE401_RS08390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BLE401_RS08395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BLE401_RS08415	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BLE401_RS08420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BLE401_RS08425	COG2304	oxidoreductase activity
BLE401_RS08435	COG0714	Associated with various cellular activities
BLE401_RS08440	COG3706	GGDEF domain
BLE401_RS08440	COG2203	Gaf domain
BLE401_RS08440	COG4251	negative regulation of phosphorylation
BLE401_RS08440	COG5001	Diguanylate cyclase
BLE401_RS08445	COG3321	synthase
BLE401_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS08445	COG0604	alcohol dehydrogenase
BLE401_RS08450	COG0633	Ferredoxin
BLE401_RS08470	COG0316	Belongs to the HesB IscA family
BLE401_RS08500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BLE401_RS08505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BLE401_RS08510	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BLE401_RS08520	COG2850	peptidyl-arginine hydroxylation
BLE401_RS08545	COG0598	Magnesium transport protein CorA
BLE401_RS08550	COG2974	May be involved in recombination
BLE401_RS08565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BLE401_RS08570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BLE401_RS08580	COG0765	amino acid transport
BLE401_RS08585	COG4597	amino acid ABC transporter
BLE401_RS08590	COG0351	phosphomethylpyrimidine kinase
BLE401_RS08595	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BLE401_RS08625	COG2333	competence protein COMEC
BLE401_RS08625	COG0658	competence protein
BLE401_RS08640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BLE401_RS08655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BLE401_RS08665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BLE401_RS08710	COG1120	ATPase activity
BLE401_RS08715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BLE401_RS08720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BLE401_RS08725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BLE401_RS08740	COG0745	RESPONSE REGULATOR receiver
BLE401_RS08745	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BLE401_RS08760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BLE401_RS08785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BLE401_RS08795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS08845	COG2205	protein histidine kinase activity
BLE401_RS08845	COG3850	Histidine kinase
BLE401_RS08845	COG4999	Histidine kinase
BLE401_RS08845	COG3437	response regulator, receiver
BLE401_RS08850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BLE401_RS08860	COG5635	Nacht domain
BLE401_RS08860	COG2319	Wd-40 repeat
BLE401_RS08870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BLE401_RS08875	COG1229	Formylmethanofuran dehydrogenase subunit A
BLE401_RS08880	COG0268	Binds directly to 16S ribosomal RNA
BLE401_RS08885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BLE401_RS08890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BLE401_RS08895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BLE401_RS08905	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BLE401_RS08910	COG0750	zinc metalloprotease
BLE401_RS08915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BLE401_RS08925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BLE401_RS08930	COG0233	cytoplasmic translational termination
BLE401_RS08935	COG0528	UMP kinase activity
BLE401_RS08940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BLE401_RS08945	COG0052	Belongs to the universal ribosomal protein uS2 family
BLE401_RS08950	COG0024	Methionine aminopeptidase
BLE401_RS08955	COG2304	oxidoreductase activity
BLE401_RS08985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BLE401_RS09050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BLE401_RS09055	COG0131	Imidazoleglycerol-phosphate dehydratase
BLE401_RS09060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BLE401_RS09075	COG2915	High frequency lysogenization protein hflD homolog
BLE401_RS09085	COG1592	Rubrerythrin
BLE401_RS09090	COG0247	lactate metabolic process
BLE401_RS09100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BLE401_RS09110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BLE401_RS09115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BLE401_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS09130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BLE401_RS09135	COG0416	fatty acid biosynthetic process
BLE401_RS09140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BLE401_RS09145	COG1399	metal-binding, possibly nucleic acid-binding protein
BLE401_RS09150	COG0424	maF-like protein
BLE401_RS09160	COG0489	protein tyrosine kinase activity
BLE401_RS09230	COG2010	Cytochrome c
BLE401_RS09250	COG1183	phosphatidylcholine synthase activity
BLE401_RS09255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BLE401_RS09265	COG0028	Belongs to the TPP enzyme family
BLE401_RS09290	COG5001	Diguanylate cyclase
BLE401_RS09310	COG4149	molybdate abc transporter
BLE401_RS09315	COG0725	ABC transporter, periplasmic molybdate-binding protein
BLE401_RS09320	COG3842	ATPase activity
BLE401_RS09325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BLE401_RS09330	COG3088	subunit of a heme lyase
BLE401_RS09340	COG2350	Protein conserved in bacteria
BLE401_RS09350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLE401_RS09360	COG1490	D-aminoacyl-tRNA deacylase activity
BLE401_RS09370	COG3261	NADH dehydrogenase
BLE401_RS09370	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BLE401_RS09380	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BLE401_RS09405	COG4191	Histidine kinase
BLE401_RS09410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BLE401_RS09415	COG2205	protein histidine kinase activity
BLE401_RS09415	COG0784	Response regulator, receiver
BLE401_RS09420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BLE401_RS09420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BLE401_RS09420	COG1703	isobutyryl-CoA mutase activity
BLE401_RS09435	COG0251	oxidation-reduction process
BLE401_RS09505	COG2226	methyltransferase
BLE401_RS09515	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS09535	COG4641	Protein conserved in bacteria
BLE401_RS09535	COG1388	LysM domain
BLE401_RS09550	COG2226	methyltransferase
BLE401_RS09555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS09560	COG0297	glycogen (starch) synthase activity
BLE401_RS09570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS09640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BLE401_RS09640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BLE401_RS09665	COG2239	Acts as a magnesium transporter
BLE401_RS09685	COG1534	Rna-binding protein
BLE401_RS09690	COG0037	tRNA processing
BLE401_RS09695	COG2226	methyltransferase
BLE401_RS09700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BLE401_RS09705	COG0287	Prephenate dehydrogenase
BLE401_RS09710	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BLE401_RS09715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BLE401_RS09725	COG0776	regulation of translation
BLE401_RS09735	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BLE401_RS09740	COG0284	orotidine-5'-phosphate decarboxylase activity
BLE401_RS09750	COG0072	phenylalanine-tRNA ligase activity
BLE401_RS09755	COG0776	regulation of translation
BLE401_RS09765	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BLE401_RS09800	COG0306	phosphate transporter
BLE401_RS09805	COG4770	biotin carboxylase activity
BLE401_RS09815	COG2204	response regulator
BLE401_RS09835	COG0651	ATP synthesis coupled electron transport
BLE401_RS09860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BLE401_RS09865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BLE401_RS09870	COG4536	flavin adenine dinucleotide binding
BLE401_RS09880	COG5002	protein histidine kinase activity
BLE401_RS09885	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BLE401_RS09905	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS09905	COG1216	Glycosyl transferase, family 2
BLE401_RS09930	COG0271	Belongs to the BolA IbaG family
BLE401_RS09935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BLE401_RS09940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BLE401_RS09965	COG0604	alcohol dehydrogenase
BLE401_RS09975	COG1160	GTP binding
BLE401_RS09980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BLE401_RS09990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BLE401_RS09995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BLE401_RS10000	COG1074	ATP-dependent DNA helicase activity
BLE401_RS10010	COG0729	surface antigen
BLE401_RS10015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BLE401_RS10020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BLE401_RS10020	COG0116	Belongs to the methyltransferase superfamily
BLE401_RS10045	COG2814	Major facilitator Superfamily
BLE401_RS10075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BLE401_RS10095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BLE401_RS10100	COG0830	nickel cation binding
BLE401_RS10105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS10110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BLE401_RS10110	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BLE401_RS10115	COG0629	single-stranded DNA binding
BLE401_RS10120	COG3162	membrane
BLE401_RS10125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BLE401_RS10135	COG1858	cytochrome C peroxidase
BLE401_RS10155	COG2205	protein histidine kinase activity
BLE401_RS10155	COG3850	Histidine kinase
BLE401_RS10155	COG3437	response regulator, receiver
BLE401_RS10155	COG4999	Histidine kinase
BLE401_RS10170	COG3956	TIGRFAM MazG family protein
BLE401_RS10190	COG0612	Peptidase, M16
BLE401_RS10195	COG0612	Peptidase, M16
BLE401_RS10205	COG4206	TonB-dependent receptor
BLE401_RS10210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BLE401_RS10215	COG0049	tRNA binding
BLE401_RS10220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BLE401_RS10225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BLE401_RS10230	COG0051	transcription antitermination factor activity, RNA binding
BLE401_RS10235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BLE401_RS10240	COG0088	Forms part of the polypeptide exit tunnel
BLE401_RS10245	COG0089	rRNA binding
BLE401_RS10255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BLE401_RS10265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BLE401_RS10280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BLE401_RS10285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BLE401_RS10290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BLE401_RS10295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BLE401_RS10300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BLE401_RS10310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BLE401_RS10315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BLE401_RS10325	COG1841	ribosomal large subunit assembly
BLE401_RS10330	COG0200	Binds to the 23S rRNA
BLE401_RS10335	COG0201	protein transport
BLE401_RS10340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BLE401_RS10345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BLE401_RS10350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BLE401_RS10355	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BLE401_RS10360	COG0202	RNA polymerase activity
BLE401_RS10365	COG0203	ribosomal protein L17
BLE401_RS10370	COG2814	Major facilitator Superfamily
BLE401_RS10380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BLE401_RS10385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BLE401_RS10395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BLE401_RS10400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BLE401_RS10405	COG0193	aminoacyl-tRNA hydrolase activity
BLE401_RS10420	COG0205	6-phosphofructokinase activity
BLE401_RS10430	COG0183	Belongs to the thiolase family
BLE401_RS10435	COG0525	valine-tRNA ligase activity
BLE401_RS10440	COG2369	cell adhesion
BLE401_RS10450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BLE401_RS10455	COG1459	type II secretion system
BLE401_RS10460	COG1450	Type ii and iii secretion system protein
BLE401_RS10470	COG0557	exoribonuclease II activity
BLE401_RS10485	COG3038	cytochrome b561
BLE401_RS10535	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BLE401_RS10540	COG2201	protein-glutamate methylesterase activity
BLE401_RS10550	COG0859	PFAM glycosyl transferase family 9
BLE401_RS10565	COG0544	peptidyl-prolyl cis-trans isomerase activity
BLE401_RS10575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BLE401_RS10580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BLE401_RS10605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLE401_RS10610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLE401_RS10645	COG0519	Catalyzes the synthesis of GMP from XMP
BLE401_RS10645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BLE401_RS10660	COG2205	protein histidine kinase activity
BLE401_RS10665	COG0737	Belongs to the 5'-nucleotidase family
BLE401_RS10680	COG4166	transmembrane transport
BLE401_RS10695	COG2274	protein secretion by the type I secretion system
BLE401_RS10705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BLE401_RS10710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BLE401_RS10715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BLE401_RS10730	COG0515	serine threonine protein kinase
BLE401_RS10730	COG2815	serine threonine protein kinase
BLE401_RS10735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BLE401_RS10740	COG0511	ligase activity, forming carbon-carbon bonds
BLE401_RS10745	COG0439	Biotin carboxylase
BLE401_RS10750	COG1994	Peptidase M50
BLE401_RS10755	COG0009	L-threonylcarbamoyladenylate synthase
BLE401_RS10790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BLE401_RS10795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BLE401_RS10800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BLE401_RS10800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BLE401_RS10810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BLE401_RS10815	COG0509	glycine decarboxylation via glycine cleavage system
BLE401_RS10820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BLE401_RS10825	COG3540	Alkaline phosphatase
BLE401_RS10885	COG2308	Evidence 4 Homologs of previously reported genes of
BLE401_RS10885	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BLE401_RS10895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS10905	COG0300	oxidoreductase activity
BLE401_RS10935	COG2205	protein histidine kinase activity
BLE401_RS10940	COG0745	RESPONSE REGULATOR receiver
BLE401_RS10945	COG3842	ATPase activity
BLE401_RS10950	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS10955	COG0367	asparagine synthase
BLE401_RS10970	COG2922	Belongs to the Smg family
BLE401_RS10975	COG0758	DNA mediated transformation
BLE401_RS10990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BLE401_RS10995	COG1185	polyribonucleotide nucleotidyltransferase activity
BLE401_RS11005	COG0795	lipopolysaccharide-transporting ATPase activity
BLE401_RS11010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BLE401_RS11030	COG3977	Valine--pyruvate aminotransferase
BLE401_RS11035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BLE401_RS11050	COG0312	modulator of DNA gyrase
BLE401_RS11060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS11085	COG5002	protein histidine kinase activity
BLE401_RS11110	COG1040	competence protein
BLE401_RS11115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BLE401_RS11150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BLE401_RS11160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BLE401_RS11175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BLE401_RS11175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BLE401_RS11180	COG0832	Belongs to the urease beta subunit family
BLE401_RS11185	COG0804	urea catabolic process
BLE401_RS11190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BLE401_RS11195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BLE401_RS11205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BLE401_RS11225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BLE401_RS11225	COG0543	2 iron, 2 sulfur cluster binding
BLE401_RS11230	COG2205	protein histidine kinase activity
BLE401_RS11245	COG0281	malic enzyme
BLE401_RS11245	COG0280	phosphate acetyltransferase
BLE401_RS11255	COG4566	intracellular signal transduction
BLE401_RS11260	COG0772	Belongs to the SEDS family
BLE401_RS11265	COG2951	lytic endotransglycosylase activity
BLE401_RS11270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BLE401_RS11275	COG1686	Belongs to the peptidase S11 family
BLE401_RS11280	COG0018	arginyl-trna synthetase
BLE401_RS11290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BLE401_RS11295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BLE401_RS11305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BLE401_RS11310	COG0459	protein refolding
BLE401_RS11340	COG0667	Aldo Keto reductase
BLE401_RS11355	COG0742	ribosomal rna small subunit methyltransferase
BLE401_RS11400	COG1408	metallophosphoesterase
BLE401_RS11410	COG1858	cytochrome C peroxidase
BLE401_RS11420	COG4953	penicillin-binding protein 1C
BLE401_RS11430	COG3550	peptidyl-serine autophosphorylation
BLE401_RS11445	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BLE401_RS11475	COG0564	pseudouridine synthase activity
BLE401_RS11480	COG0352	thiamine-phosphate diphosphorylase activity
BLE401_RS11485	COG2354	Protein conserved in bacteria
BLE401_RS11515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BLE401_RS11520	COG4208	sulfate ABC transporter
BLE401_RS11525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BLE401_RS11540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BLE401_RS11550	COG2205	protein histidine kinase activity
BLE401_RS11555	COG4999	Histidine kinase
BLE401_RS11555	COG3850	Histidine kinase
BLE401_RS11555	COG2205	protein histidine kinase activity
BLE401_RS11555	COG3437	response regulator, receiver
BLE401_RS11610	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BLE401_RS11615	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BLE401_RS11625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BLE401_RS11660	COG0410	ABC transporter
BLE401_RS11685	COG5635	Nacht domain
BLE401_RS11685	COG2319	Wd-40 repeat
BLE401_RS11690	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS11710	COG0863	Belongs to the N(4) N(6)-methyltransferase family
BLE401_RS11720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS11740	COG0606	chelatase, subunit chli
BLE401_RS11755	COG1842	Phage shock protein A
BLE401_RS11790	COG1309	transcriptional regulator
BLE401_RS11795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BLE401_RS11840	COG3909	cytochrome
BLE401_RS11860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BLE401_RS11865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BLE401_RS11870	COG1993	acr, cog1993
BLE401_RS11885	COG2208	phosphoserine phosphatase activity
BLE401_RS11905	COG2337	Toxic component of a toxin-antitoxin (TA) module
BLE401_RS11915	COG0582	viral genome integration into host DNA
BLE401_RS11940	COG0494	nUDIX hydrolase
BLE401_RS11945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BLE401_RS11950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BLE401_RS11960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BLE401_RS11965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BLE401_RS12000	COG0702	epimerase
BLE401_RS12005	COG1733	regulation of RNA biosynthetic process
BLE401_RS12035	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BLE401_RS12085	COG1064	alcohol dehydrogenase
BLE401_RS12125	COG4555	ABC transporter
BLE401_RS12145	COG1360	Flagellar Motor Protein
BLE401_RS12160	COG0720	synthase
BLE401_RS12170	COG3300	MHYT domain
BLE401_RS12170	COG5001	Diguanylate cyclase
BLE401_RS12175	COG2183	response to ionizing radiation
BLE401_RS12190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BLE401_RS12200	COG0745	RESPONSE REGULATOR receiver
BLE401_RS12205	COG1234	tRNA 3'-trailer cleavage
BLE401_RS12210	COG3180	Ammonia monooxygenase
BLE401_RS12220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BLE401_RS12245	COG1280	lysine exporter protein (LysE YggA)
BLE401_RS12255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BLE401_RS12265	COG4172	Belongs to the ABC transporter superfamily
BLE401_RS12270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BLE401_RS12275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS12290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BLE401_RS12320	COG0650	Formate hydrogenlyase subunit 4
BLE401_RS12370	COG2308	Evidence 4 Homologs of previously reported genes of
BLE401_RS12385	COG2319	Wd-40 repeat
BLE401_RS12385	COG4249	Peptidase C14 caspase catalytic subunit p20
BLE401_RS12405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BLE401_RS12410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BLE401_RS12420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BLE401_RS12425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BLE401_RS12425	COG0047	phosphoribosylformylglycinamidine synthase activity
BLE401_RS12445	COG0784	Response regulator, receiver
BLE401_RS12445	COG2205	protein histidine kinase activity
BLE401_RS12445	COG5002	protein histidine kinase activity
BLE401_RS12490	COG0643	Histidine kinase
BLE401_RS12490	COG2198	Histidine kinase
BLE401_RS12490	COG0784	Response regulator, receiver
BLE401_RS12535	COG2890	protein-(glutamine-N5) methyltransferase activity
BLE401_RS12545	COG0640	Transcriptional regulator
BLE401_RS12615	COG0582	viral genome integration into host DNA
BLE401_RS12635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BLE401_RS12640	COG0077	Prephenate dehydratase
BLE401_RS12640	COG1605	Chorismate mutase
BLE401_RS12650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BLE401_RS12680	COG1012	belongs to the aldehyde dehydrogenase family
BLE401_RS12695	COG2319	Wd-40 repeat
BLE401_RS12695	COG4249	Peptidase C14 caspase catalytic subunit p20
BLE401_RS12750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BLE401_RS12755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BLE401_RS12765	COG1741	Belongs to the pirin family
BLE401_RS12770	COG3384	dioxygenase
BLE401_RS12775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BLE401_RS12835	COG0850	regulation of cytokinetic process
BLE401_RS12840	COG2894	cell division
BLE401_RS12845	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BLE401_RS12860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLE401_RS12890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BLE401_RS12905	COG0795	lipopolysaccharide-transporting ATPase activity
BLE401_RS12920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLE401_RS12940	COG5464	transposase or invertase
BLE401_RS12960	COG0784	Response regulator, receiver
BLE401_RS12960	COG2205	protein histidine kinase activity
BLE401_RS12985	COG3245	cytochrome
BLE401_RS12995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BLE401_RS13000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BLE401_RS13015	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BLE401_RS13025	COG0714	Associated with various cellular activities
BLE401_RS13030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS13035	COG3258	Cytochrome c
BLE401_RS13060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BLE401_RS13065	COG2205	protein histidine kinase activity
BLE401_RS13065	COG0784	Response regulator, receiver
BLE401_RS13070	COG0583	DNA-binding transcription factor activity
BLE401_RS13090	COG1858	cytochrome C peroxidase
BLE401_RS13100	COG1643	Atp-dependent helicase
BLE401_RS13110	COG0167	dihydroorotate dehydrogenase activity
BLE401_RS13210	COG0616	signal peptide processing
BLE401_RS13210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BLE401_RS13225	COG2201	protein-glutamate methylesterase activity
BLE401_RS13235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BLE401_RS13240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BLE401_RS13245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BLE401_RS13250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BLE401_RS13275	COG2003	Belongs to the UPF0758 family
BLE401_RS13285	COG2177	Part of the ABC transporter FtsEX involved in
BLE401_RS13325	COG1024	Enoyl-CoA hydratase
BLE401_RS13345	COG1862	Preprotein translocase
BLE401_RS13350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BLE401_RS13355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BLE401_RS13360	COG0842	Transport permease protein
BLE401_RS13365	COG1131	(ABC) transporter
BLE401_RS13380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BLE401_RS13385	COG4591	ABC-type transport system involved in lipoprotein release permease component
BLE401_RS13390	COG1136	(ABC) transporter
BLE401_RS13410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BLE401_RS13420	COG0513	Belongs to the DEAD box helicase family
BLE401_RS13465	COG2304	oxidoreductase activity
BLE401_RS13480	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
BLE401_RS13495	COG3411	Ferredoxin
BLE401_RS13515	COG0464	growth
BLE401_RS13520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BLE401_RS13530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BLE401_RS13535	COG0084	hydrolase, TatD family'
BLE401_RS13550	COG3158	transport of potassium into the cell
BLE401_RS13565	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BLE401_RS13575	COG3383	formate dehydrogenase (NAD+) activity
BLE401_RS13580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BLE401_RS13595	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BLE401_RS13630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BLE401_RS13645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BLE401_RS13660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BLE401_RS13675	COG1131	(ABC) transporter
BLE401_RS13685	COG4783	chaperone-mediated protein folding
BLE401_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS13740	COG1965	Belongs to the frataxin family
BLE401_RS13745	COG0463	Glycosyl transferase, family 2
BLE401_RS13760	COG2814	Major facilitator Superfamily
BLE401_RS13765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BLE401_RS13820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BLE401_RS13855	COG3437	response regulator, receiver
BLE401_RS13855	COG2205	protein histidine kinase activity
BLE401_RS13855	COG3850	Histidine kinase
BLE401_RS13855	COG4999	Histidine kinase
BLE401_RS13860	COG2010	Cytochrome c
BLE401_RS13865	COG0753	catalase activity
BLE401_RS13875	COG0708	Exodeoxyribonuclease III
BLE401_RS13890	COG1420	regulation of RNA biosynthetic process
BLE401_RS13895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BLE401_RS13900	COG0443	Heat shock 70 kDa protein
BLE401_RS13910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BLE401_RS13915	COG0602	queuosine metabolic process
BLE401_RS13925	COG1131	(ABC) transporter
BLE401_RS13940	COG0254	rRNA binding
BLE401_RS13945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BLE401_RS13955	COG2813	Specifically methylates the guanine in position
BLE401_RS13955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BLE401_RS13960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BLE401_RS13980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BLE401_RS13985	COG1538	Outer membrane efflux protein
BLE401_RS13990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BLE401_RS13995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BLE401_RS14005	COG2703	oxygen carrier activity
BLE401_RS14010	COG1846	Transcriptional regulator
BLE401_RS14020	COG0791	NLP P60 protein
BLE401_RS14030	COG0443	Heat shock 70 kDa protein
BLE401_RS14040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BLE401_RS14070	COG2198	Histidine kinase
BLE401_RS14070	COG0643	Histidine kinase
BLE401_RS14070	COG0784	Response regulator, receiver
BLE401_RS14075	COG0840	transmembrane signaling receptor activity
BLE401_RS14100	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BLE401_RS14105	COG0237	dephospho-CoA kinase activity
BLE401_RS14165	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS14175	COG0183	Belongs to the thiolase family
BLE401_RS14180	COG1519	Transferase
BLE401_RS14185	COG0784	Response regulator, receiver
BLE401_RS14185	COG3437	response regulator, receiver
BLE401_RS14190	COG0768	penicillin binding
BLE401_RS14205	COG4137	Cytochrome C assembly protein
BLE401_RS14210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BLE401_RS14220	COG2226	methyltransferase
BLE401_RS14225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BLE401_RS14230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BLE401_RS14245	COG2969	positive regulation of protein catabolic process
BLE401_RS14250	COG2857	Cytochrome c1
BLE401_RS14255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BLE401_RS14260	COG0723	plastoquinol--plastocyanin reductase activity
BLE401_RS14270	COG0033	Phosphoglucomutase
BLE401_RS14280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BLE401_RS14290	COG0523	cobalamin synthesis protein
BLE401_RS14315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BLE401_RS14355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BLE401_RS14375	COG0019	diaminopimelate decarboxylase activity
BLE401_RS14390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BLE401_RS14415	COG0515	serine threonine protein kinase
BLE401_RS14415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS14425	COG0552	protein localization to endoplasmic reticulum
BLE401_RS14430	COG0243	molybdopterin cofactor binding
BLE401_RS14435	COG0437	4 iron, 4 sulfur cluster binding
BLE401_RS14440	COG3302	dmso reductase anchor subunit
BLE401_RS14455	COG4251	negative regulation of phosphorylation
BLE401_RS14455	COG3706	GGDEF domain
BLE401_RS14455	COG2203	Gaf domain
BLE401_RS14455	COG5001	Diguanylate cyclase
BLE401_RS14460	COG2205	protein histidine kinase activity
BLE401_RS14460	COG0784	Response regulator, receiver
BLE401_RS14490	COG1573	uracil-dna glycosylase
BLE401_RS14510	COG1218	3'(2'),5'-bisphosphate nucleotidase
BLE401_RS14540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BLE401_RS14550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BLE401_RS14560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BLE401_RS14565	COG0081	regulation of translation
BLE401_RS14570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BLE401_RS14575	COG0222	ribosome binding
BLE401_RS14580	COG0085	RNA polymerase activity
BLE401_RS14585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BLE401_RS14610	COG3275	phosphorelay sensor kinase activity
BLE401_RS14625	COG4932	domain protein
BLE401_RS14625	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
BLE401_RS14625	COG3266	domain, Protein
BLE401_RS14630	COG4932	domain protein
BLE401_RS14685	COG2801	Transposase and inactivated derivatives
BLE401_RS14690	COG2842	Transposition protein
BLE401_RS14920	COG0515	serine threonine protein kinase
BLE401_RS14920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS14930	COG0501	Belongs to the peptidase M48B family
BLE401_RS14955	COG1127	ABC transporter
BLE401_RS14960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BLE401_RS14965	COG3012	SEC-C Motif Domain Protein
BLE401_RS14980	COG3284	Transcriptional regulator
BLE401_RS14985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BLE401_RS14990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BLE401_RS14995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BLE401_RS15000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BLE401_RS15005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BLE401_RS15010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BLE401_RS15015	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BLE401_RS15020	COG0356	it plays a direct role in the translocation of protons across the membrane
BLE401_RS15030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BLE401_RS15050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BLE401_RS15055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BLE401_RS15060	COG1555	photosystem II stabilization
BLE401_RS15065	COG1007	ATP synthesis coupled electron transport
BLE401_RS15080	COG0713	ATP synthesis coupled electron transport
BLE401_RS15095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLE401_RS15100	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BLE401_RS15105	COG1034	ATP synthesis coupled electron transport
BLE401_RS15115	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BLE401_RS15120	COG0649	NAD binding
BLE401_RS15125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLE401_RS15130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLE401_RS15135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLE401_RS15140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BLE401_RS15145	COG5001	Diguanylate cyclase
BLE401_RS15145	COG3300	MHYT domain
BLE401_RS15155	COG4106	trans-aconitate 2-methyltransferase activity
BLE401_RS15165	COG0463	Glycosyl transferase, family 2
BLE401_RS15170	COG0367	asparagine synthase
BLE401_RS15175	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS15195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BLE401_RS15200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BLE401_RS15220	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BLE401_RS15235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLE401_RS15240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS15280	COG4191	Histidine kinase
BLE401_RS15300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BLE401_RS15305	COG4232	protein-disulfide reductase activity
BLE401_RS15330	COG0166	Belongs to the GPI family
BLE401_RS15360	COG1832	CoA-binding protein
BLE401_RS15365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BLE401_RS15395	COG0450	alkyl hydroperoxide reductase
BLE401_RS15400	COG0791	NLP P60 protein
BLE401_RS15410	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS15410	COG1216	Glycosyl transferase, family 2
BLE401_RS15420	COG0693	protein deglycase activity
BLE401_RS15425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BLE401_RS15440	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
BLE401_RS15450	COG0390	transport system, permease component
BLE401_RS15455	COG0330	HflC and HflK could
BLE401_RS15470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BLE401_RS15480	COG0243	molybdopterin cofactor binding
BLE401_RS15485	COG2146	nitrite reductase [NAD(P)H] activity
BLE401_RS15490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BLE401_RS15495	COG1116	anion transmembrane transporter activity
BLE401_RS15500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BLE401_RS15505	COG1116	anion transmembrane transporter activity
BLE401_RS15505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BLE401_RS15510	COG3707	response regulator
BLE401_RS15520	COG1960	acyl-CoA dehydrogenase activity
BLE401_RS15535	COG1496	oxidoreductase activity
BLE401_RS15540	COG0704	Plays a role in the regulation of phosphate uptake
BLE401_RS15545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BLE401_RS15550	COG0573	inorganic phosphate transmembrane transporter activity
BLE401_RS15560	COG2902	Dehydrogenase
BLE401_RS15565	COG0515	serine threonine protein kinase
BLE401_RS15565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS15570	COG3243	poly(R)-hydroxyalkanoic acid synthase
BLE401_RS15580	COG0604	alcohol dehydrogenase
BLE401_RS15585	COG0741	lytic transglycosylase activity
BLE401_RS15585	COG1196	nuclear chromosome segregation
BLE401_RS15585	COG0739	heme binding
BLE401_RS15595	COG3932	Exopolysaccharide synthesis, ExoD
BLE401_RS15600	COG0179	Fumarylacetoacetate (FAA) hydrolase
BLE401_RS15605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BLE401_RS15605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BLE401_RS15620	COG0589	response to stress
BLE401_RS15625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLE401_RS15645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BLE401_RS15655	COG0328	RNA-DNA hybrid ribonuclease activity
BLE401_RS15660	COG2210	Belongs to the sulfur carrier protein TusA family
BLE401_RS15665	COG0425	Belongs to the sulfur carrier protein TusA family
BLE401_RS15670	COG1648	precorrin-2 dehydrogenase activity
BLE401_RS15670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BLE401_RS15680	COG2217	Heavy metal translocating P-type atpase
BLE401_RS15690	COG1138	Cytochrome C-type biogenesis protein
BLE401_RS15700	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BLE401_RS15730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BLE401_RS15745	COG4942	peptidase
BLE401_RS15750	COG1705	Flagellar rod assembly protein muramidase FlgJ
BLE401_RS15750	COG1388	LysM domain
BLE401_RS15760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BLE401_RS15765	COG0751	glycine-tRNA ligase activity
BLE401_RS15770	COG0752	glycyl-tRNA synthetase alpha subunit
BLE401_RS15795	COG2205	protein histidine kinase activity
BLE401_RS15795	COG2202	Pas domain
BLE401_RS15810	COG1346	cytolysis
BLE401_RS15820	COG2084	Dehydrogenase
BLE401_RS15825	COG0504	CTP synthase activity
BLE401_RS15850	COG0484	heat shock protein binding
BLE401_RS15855	COG2165	general secretion pathway protein
BLE401_RS15870	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BLE401_RS15900	COG0557	exoribonuclease II activity
BLE401_RS15915	COG0825	malonyl-CoA metabolic process
BLE401_RS15925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BLE401_RS15930	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BLE401_RS15935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BLE401_RS15945	COG0588	phosphoglycerate mutase activity
BLE401_RS15950	COG0494	nUDIX hydrolase
BLE401_RS15965	COG1459	type II secretion system
BLE401_RS15970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BLE401_RS15975	COG1923	regulation of RNA biosynthetic process
BLE401_RS15980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BLE401_RS15995	COG0330	HflC and HflK could
BLE401_RS16000	COG0330	HflC and HflK could
BLE401_RS16010	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BLE401_RS16015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BLE401_RS16030	COG0430	RNA-3'-phosphate cyclase activity
BLE401_RS16040	COG0302	gtp cyclohydrolase
BLE401_RS16045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BLE401_RS16050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BLE401_RS16065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS16065	COG2205	protein histidine kinase activity
BLE401_RS16075	COG2976	Protein conserved in bacteria
BLE401_RS16080	COG0124	histidyl-tRNA synthetase
BLE401_RS16085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BLE401_RS16090	COG1426	Protein conserved in bacteria
BLE401_RS16100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BLE401_RS16105	COG0105	UTP biosynthetic process
BLE401_RS16120	COG0837	glucose binding
BLE401_RS16135	COG0004	ammonium transporteR
BLE401_RS16140	COG0004	ammonium transporteR
BLE401_RS16145	COG0347	Belongs to the P(II) protein family
BLE401_RS16150	COG1199	ATP-dependent helicase activity
BLE401_RS16150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BLE401_RS16185	COG0180	Tryptophanyl-tRNA synthetase
BLE401_RS16195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BLE401_RS16200	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BLE401_RS16205	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BLE401_RS16210	COG2205	protein histidine kinase activity
BLE401_RS16215	COG0745	RESPONSE REGULATOR receiver
BLE401_RS16225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BLE401_RS16230	COG0436	Aminotransferase
BLE401_RS16235	COG2171	N-acyltransferase activity
BLE401_RS16245	COG1660	Displays ATPase and GTPase activities
BLE401_RS16265	COG0829	nickel cation binding
BLE401_RS16270	COG2885	chlorophyll binding
BLE401_RS16290	COG3038	cytochrome b561
BLE401_RS16320	COG2205	protein histidine kinase activity
BLE401_RS16320	COG2202	Pas domain
BLE401_RS16325	COG0343	queuine tRNA-ribosyltransferase activity
BLE401_RS16330	COG0297	glycogen (starch) synthase activity
BLE401_RS16340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BLE401_RS16345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BLE401_RS16350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BLE401_RS16360	COG2089	acid synthase
BLE401_RS16370	COG1083	cytidylyl-transferase
BLE401_RS16375	COG0012	GTP binding
BLE401_RS16380	COG2205	protein histidine kinase activity
BLE401_RS16380	COG2198	Histidine kinase
BLE401_RS16380	COG0784	Response regulator, receiver
BLE401_RS16405	COG0784	Response regulator, receiver
BLE401_RS16405	COG5002	protein histidine kinase activity
BLE401_RS16405	COG2198	Histidine kinase
BLE401_RS16410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BLE401_RS16415	COG2304	oxidoreductase activity
BLE401_RS16425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BLE401_RS16440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BLE401_RS16445	COG1137	ATPase activity
BLE401_RS16450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BLE401_RS16465	COG0358	DNA primase activity
BLE401_RS16470	COG1610	YqeY-like protein
BLE401_RS16485	COG0686	Belongs to the AlaDH PNT family
BLE401_RS16490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BLE401_RS16495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BLE401_RS16505	COG4260	virion core protein, lumpy skin disease virus
BLE401_RS16520	COG2911	Protein conserved in bacteria
BLE401_RS16530	COG3852	Histidine kinase
BLE401_RS16540	COG1968	undecaprenyl-diphosphatase activity
BLE401_RS16545	COG0542	response to heat
BLE401_RS16585	COG0617	tRNA 3'-terminal CCA addition
BLE401_RS16590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BLE401_RS16595	COG0497	DNA recombination
BLE401_RS16605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BLE401_RS16610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BLE401_RS16625	COG1104	cysteine desulfurase activity
BLE401_RS16630	COG1104	cysteine desulfurase activity
BLE401_RS16635	COG1959	2 iron, 2 sulfur cluster binding
BLE401_RS16655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BLE401_RS16665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BLE401_RS16700	COG0756	dUTP diphosphatase activity
BLE401_RS16710	COG1215	transferase activity, transferring glycosyl groups
BLE401_RS16715	COG0484	heat shock protein binding
BLE401_RS16720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BLE401_RS16725	COG2923	Belongs to the DsrF TusC family
BLE401_RS16730	COG2168	tRNA wobble position uridine thiolation
BLE401_RS16735	COG2920	part of a sulfur-relay system
BLE401_RS16760	COG1611	Belongs to the LOG family
BLE401_RS16765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS16770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BLE401_RS16790	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BLE401_RS16805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BLE401_RS16810	COG2264	protein methyltransferase activity
BLE401_RS16820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BLE401_RS16830	COG0616	signal peptide processing
BLE401_RS16835	COG1131	(ABC) transporter
BLE401_RS16860	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BLE401_RS16870	COG0535	radical SAM domain protein
BLE401_RS16875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BLE401_RS16885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BLE401_RS16895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BLE401_RS16905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BLE401_RS16915	COG2226	methyltransferase
BLE401_RS16925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BLE401_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS16960	COG2208	phosphoserine phosphatase activity
BLE401_RS16975	COG0784	Response regulator, receiver
BLE401_RS16975	COG2205	protein histidine kinase activity
BLE401_RS16990	COG2358	TRAP transporter, solute receptor (TAXI family
BLE401_RS17000	COG3206	protein involved in exopolysaccharide biosynthesis
BLE401_RS17000	COG0489	protein tyrosine kinase activity
BLE401_RS17025	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS17040	COG2022	thiamine diphosphate biosynthetic process
BLE401_RS17050	COG0352	thiamine-phosphate diphosphorylase activity
BLE401_RS17055	COG2205	protein histidine kinase activity
BLE401_RS17060	COG0745	RESPONSE REGULATOR receiver
BLE401_RS17070	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BLE401_RS17070	COG0644	oxidoreductase
BLE401_RS17075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BLE401_RS17080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BLE401_RS17085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BLE401_RS17095	COG1640	4-alpha-glucanotransferase
BLE401_RS17105	COG0247	lactate metabolic process
BLE401_RS17110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BLE401_RS17140	COG0840	transmembrane signaling receptor activity
BLE401_RS17155	COG0569	domain protein
BLE401_RS17160	COG2204	response regulator
BLE401_RS17165	COG5000	phosphorelay sensor kinase activity
BLE401_RS17175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BLE401_RS17180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BLE401_RS17185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BLE401_RS17215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BLE401_RS17225	COG4191	Histidine kinase
BLE401_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS17250	COG0697	spore germination
BLE401_RS17265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS17280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BLE401_RS17285	COG0732	type I restriction modification DNA specificity domain
BLE401_RS17290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BLE401_RS17300	COG1960	acyl-CoA dehydrogenase activity
BLE401_RS17320	COG1160	GTP binding
BLE401_RS17325	COG1752	Esterase of the alpha-beta hydrolase superfamily
BLE401_RS17370	COG0288	reversible hydration of carbon dioxide
BLE401_RS17375	COG4717	serine-type aminopeptidase activity
BLE401_RS17395	COG2203	Gaf domain
BLE401_RS17395	COG2199	diguanylate cyclase activity
BLE401_RS17400	COG2204	response regulator
BLE401_RS17405	COG1192	Involved in chromosome partitioning
BLE401_RS17420	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BLE401_RS17425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BLE401_RS17435	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BLE401_RS17455	COG4656	Part of a membrane complex involved in electron transport
BLE401_RS17460	COG0408	coproporphyrinogen oxidase activity
BLE401_RS17465	COG0009	L-threonylcarbamoyladenylate synthase
BLE401_RS17470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BLE401_RS17500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BLE401_RS17500	COG0574	Belongs to the PEP-utilizing enzyme family
BLE401_RS17515	COG0697	spore germination
BLE401_RS17520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BLE401_RS17525	COG0668	transmembrane transport
BLE401_RS17535	COG2204	response regulator
BLE401_RS17540	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BLE401_RS17560	COG0667	Aldo Keto reductase
BLE401_RS17575	COG2205	protein histidine kinase activity
BLE401_RS17575	COG2202	Pas domain
BLE401_RS17580	COG3047	cAMP biosynthetic process
BLE401_RS17585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BLE401_RS17610	COG2833	Protein of unknown function (DUF455)
BLE401_RS17630	COG0840	transmembrane signaling receptor activity
BLE401_RS17635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BLE401_RS17640	COG0107	imidazoleglycerol-phosphate synthase activity
BLE401_RS17650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BLE401_RS17660	COG0140	phosphoribosyl-ATP diphosphatase activity
BLE401_RS17670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BLE401_RS17675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BLE401_RS17680	COG0805	protein transport
BLE401_RS17740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BLE401_RS17755	COG0741	lytic transglycosylase activity
BLE401_RS17765	COG3577	Aspartyl protease
BLE401_RS17775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BLE401_RS17785	COG2885	chlorophyll binding
BLE401_RS17790	COG0823	Involved in the tonB-independent uptake of proteins
BLE401_RS17805	COG0811	peptide transport
BLE401_RS17810	COG0824	Thioesterase
BLE401_RS17815	COG2255	four-way junction helicase activity
BLE401_RS17820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BLE401_RS17845	COG0563	adenylate kinase activity
BLE401_RS17850	COG2205	protein histidine kinase activity
BLE401_RS17850	COG2202	Pas domain
BLE401_RS17860	COG1012	belongs to the aldehyde dehydrogenase family
BLE401_RS17870	COG3030	protein affecting phage T7 exclusion by the F plasmid
BLE401_RS17880	COG0488	(ABC) transporter
BLE401_RS17895	COG0586	Pfam SNARE associated Golgi protein
BLE401_RS17905	COG0277	FAD linked oxidase domain protein
BLE401_RS17920	COG2957	Belongs to the agmatine deiminase family
BLE401_RS17925	COG0156	8-amino-7-oxononanoate synthase activity
BLE401_RS17935	COG0270	DNA (cytosine-5-)-methyltransferase activity
BLE401_RS17945	COG5002	protein histidine kinase activity
BLE401_RS17945	COG0784	Response regulator, receiver
BLE401_RS17950	COG2205	protein histidine kinase activity
BLE401_RS17950	COG0784	Response regulator, receiver
BLE401_RS17955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BLE401_RS17960	COG0084	hydrolase, TatD family'
BLE401_RS17965	COG1704	LemA family
BLE401_RS17970	COG1132	(ABC) transporter
BLE401_RS17975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BLE401_RS17985	COG0641	radical SAM
BLE401_RS17995	COG0784	Response regulator, receiver
BLE401_RS17995	COG5002	protein histidine kinase activity
BLE401_RS17995	COG2198	Histidine kinase
BLE401_RS18005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BLE401_RS18010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BLE401_RS18015	COG1217	gtp-binding protein TYPA
BLE401_RS18020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BLE401_RS18035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BLE401_RS18045	COG0473	3-isopropylmalate dehydrogenase activity
BLE401_RS18050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BLE401_RS18060	COG0101	tRNA pseudouridine synthase activity
BLE401_RS18065	COG0582	viral genome integration into host DNA
BLE401_RS18070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BLE401_RS18080	COG2890	protein-(glutamine-N5) methyltransferase activity
BLE401_RS18115	COG0523	cobalamin synthesis protein
BLE401_RS18155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BLE401_RS18165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BLE401_RS18170	COG2217	Heavy metal translocating P-type atpase
BLE401_RS18180	COG3278	Belongs to the heme-copper respiratory oxidase family
BLE401_RS18195	COG2010	Cytochrome c
BLE401_RS18210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BLE401_RS18225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site