locus-tag class description BLE401_RS00115 ENOG4105RWS endonuclease I BLE401_RS00120 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BLE401_RS00260 ENOG4105F7V ErfK ybiS ycfS ynhG family protein BLE401_RS00265 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BLE401_RS00275 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BLE401_RS00295 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BLE401_RS00300 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BLE401_RS00305 ENOG4105DTN riboflavin biosynthesis protein ribF BLE401_RS00310 ENOG4105CJR Integral membrane protein (MviN BLE401_RS00315 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BLE401_RS00350 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BLE401_RS00355 ENOG4105C6Y Udp-glucose 6-dehydrogenase BLE401_RS00375 ENOG4105BZU Histidine kinase BLE401_RS00385 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BLE401_RS00395 ENOG4105D4A Cell wall formation (By similarity) BLE401_RS00400 ENOG4105CPF Cell wall formation (By similarity) BLE401_RS00405 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BLE401_RS00410 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BLE401_RS00415 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BLE401_RS00420 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BLE401_RS00430 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BLE401_RS00435 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BLE401_RS00455 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A BLE401_RS00470 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BLE401_RS00475 ENOG4105C01 Dihydroxy-acid dehydratase BLE401_RS00495 ENOG4105C1J atp-dependent rna helicase BLE401_RS00510 ENOG4105C8V SAICAR synthetase BLE401_RS00515 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BLE401_RS00520 ENOG4108VFZ ribulose bisphosphate carboxylase, small BLE401_RS00525 ENOG4105E9H Lytic Murein transglycosylase BLE401_RS00530 ENOG4105DJ4 phosphatidylserine decarboxylase BLE401_RS00535 ENOG4106E5D Protein of unknown function (DUF461) BLE401_RS00550 ENOG4105E66 phosphoriboisomerase A BLE401_RS00565 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BLE401_RS00575 ENOG4108VAU general secretion pathway protein G BLE401_RS00590 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BLE401_RS00625 ENOG4105E0Y RtcB Protein BLE401_RS00640 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BLE401_RS00645 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BLE401_RS00655 ENOG4105C3R Methionine synthase BLE401_RS00700 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BLE401_RS00710 ENOG4105NAU thioesterase Superfamily protein BLE401_RS00725 ENOG4107E2E PKHD-type hydroxylase BLE401_RS00730 ENOG4108ESX Receptor BLE401_RS00735 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BLE401_RS00740 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BLE401_RS00750 ENOG4105NBF ammecr1 domain protein BLE401_RS00755 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein BLE401_RS00780 ENOG4105DGN Electron transport complex BLE401_RS00785 ENOG4108R3D Electron transport complex BLE401_RS00805 ENOG4105D6A Electron transport complex BLE401_RS00810 ENOG4108UQQ Electron transport complex BLE401_RS00815 ENOG4105F8J Adenylate Guanylate cyclase BLE401_RS00825 ENOG4108HMN Caspase domain BLE401_RS00850 ENOG4107RUE extracellular solute-binding protein family 1 BLE401_RS00885 ENOG4107QSN dihydrolipoamide acetyltransferase BLE401_RS00890 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BLE401_RS00895 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BLE401_RS00900 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BLE401_RS00905 ENOG4105VG0 50S ribosomal protein l34 BLE401_RS00910 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BLE401_RS00915 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BLE401_RS00920 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BLE401_RS00940 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BLE401_RS00945 ENOG4105D6J arsenicaL-resistance protein BLE401_RS00950 ENOG4108UXE Protein tyrosine phosphatase BLE401_RS00965 ENOG4108RIR Molybdenum cofactor biosynthesis protein BLE401_RS00980 ENOG4105BZU Histidine kinase BLE401_RS00990 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BLE401_RS00995 ENOG4108M6X Dehydrogenase BLE401_RS01005 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) BLE401_RS01015 ENOG4105E0M Sulfatase BLE401_RS01025 ENOG4105CH5 extracellular solute-binding protein, family 7 BLE401_RS01035 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BLE401_RS01040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BLE401_RS01045 ENOG4105BZU Histidine kinase BLE401_RS01050 ENOG4106BE1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity) BLE401_RS01055 ENOG4105DIT ErfK YbiS YcfS YnhG family protein BLE401_RS01060 ENOG4105EAQ (twin-arginine translocation) pathway signal BLE401_RS01070 ENOG4105CM2 brancheD-chain amino acid aminotransferase BLE401_RS01080 ENOG4105XA0 heptosyltransferase ii BLE401_RS01090 ENOG4105CD3 dihydroorotase BLE401_RS01110 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BLE401_RS01115 ENOG4105BZU Histidine kinase BLE401_RS01120 ENOG4105BZU Histidine kinase BLE401_RS01135 ENOG4105CS1 NAD(P)H quinone oxidoreductase BLE401_RS01140 ENOG4105EJ9 Membrane BLE401_RS01145 ENOG4105K8N protein family UPF0079, ATPase BLE401_RS01150 ENOG4105CDV Ompa motb domain protein BLE401_RS01160 ENOG4105E3S small subunit BLE401_RS01175 ENOG4105CW7 secretion protein, HlyD family BLE401_RS01180 ENOG4105C19 ABC transporter BLE401_RS01185 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BLE401_RS01190 ENOG4105C4R Atp-dependent dna helicase BLE401_RS01205 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BLE401_RS01240 ENOG4105DFE Dna adenine methylase BLE401_RS01245 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BLE401_RS01280 ENOG4108VAU general secretion pathway protein G BLE401_RS01300 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) BLE401_RS01305 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) BLE401_RS01380 ENOG4105BZU Histidine kinase BLE401_RS01390 ENOG4106PMH Extracellular solute-binding protein family 3 BLE401_RS01410 ENOG4108UB4 uncharacterized protein ygjQ BLE401_RS01415 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BLE401_RS01420 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BLE401_RS01460 ENOG4105DZR Type I site-specific deoxyribonuclease BLE401_RS01480 ENOG4105CA9 Pyruvate kinase BLE401_RS01485 ENOG4105D2N Aldolase BLE401_RS01495 ENOG4105D0B Nitrogenase protein alpha chain BLE401_RS01515 ENOG4105EGS Mechanosensitive ion channel BLE401_RS01520 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BLE401_RS01530 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) BLE401_RS01535 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BLE401_RS01550 ENOG4105DJV ribulose-phosphate 3-epimerase BLE401_RS01555 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BLE401_RS01570 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BLE401_RS01575 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BLE401_RS01595 ENOG4105BZU Histidine kinase BLE401_RS01605 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BLE401_RS01625 ENOG4105C8Q Methyl-accepting chemotaxis BLE401_RS01630 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BLE401_RS01640 ENOG4107QWP ABC-2 type transporter BLE401_RS01645 ENOG4105CJ1 ABC, transporter BLE401_RS01665 ENOG4105BZU Histidine kinase BLE401_RS01675 ENOG4108JQ5 ABC transporter BLE401_RS01680 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class BLE401_RS01685 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BLE401_RS01690 ENOG4105BZU Histidine kinase BLE401_RS01695 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BLE401_RS01700 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BLE401_RS01720 ENOG4105SG9 biopolymer transport protein, ExbD BLE401_RS01725 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BLE401_RS01730 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BLE401_RS01740 ENOG4105C3F Signal peptidase i BLE401_RS01745 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BLE401_RS01755 ENOG4105C0H protease BLE401_RS01770 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BLE401_RS01785 ENOG4105CSR polyphosphate kinase 2 BLE401_RS01805 ENOG4105E4C Lytic transglycosylase catalytic BLE401_RS01820 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BLE401_RS01825 ENOG4105BZ1 (ABC) transporter BLE401_RS01840 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BLE401_RS01845 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BLE401_RS01850 ENOG4107PE3 Mammalian cell entry related domain protein BLE401_RS01880 ENOG4105CJW magnesium transporter BLE401_RS01885 ENOG4108IPT Naphthoate synthase BLE401_RS01895 ENOG4108Z6B deaminase BLE401_RS01905 ENOG4105DEF Extracellular solute-binding protein, family 5 BLE401_RS01935 ENOG4105C5H ABC transporter BLE401_RS01940 ENOG4105BZU Histidine kinase BLE401_RS01945 ENOG4105CUX Signal transduction histidine kinase BLE401_RS01950 ENOG4105BZU Histidine kinase BLE401_RS01965 ENOG4105BZU Histidine kinase BLE401_RS01980 ENOG4105CAK Cell division ATP-binding protein ftsE BLE401_RS01985 ENOG4105CTB Polyprenyl synthetase BLE401_RS01990 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) BLE401_RS01995 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BLE401_RS02005 ENOG4108WBT adenosyltransferase BLE401_RS02015 ENOG4105C0H protease BLE401_RS02025 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BLE401_RS02040 ENOG4105CVM Molybdenum cofactor synthesis domain protein BLE401_RS02045 ENOG4105BZU Histidine kinase BLE401_RS02075 ENOG4105CDA abc transporter atp-binding protein BLE401_RS02095 ENOG4108A51 BLE401_RS02100 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein BLE401_RS02110 ENOG4105BZU Histidine kinase BLE401_RS02120 ENOG4108ZUW Major pilin subunit BLE401_RS02130 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BLE401_RS02140 ENOG4105VT3 DNA binding domain protein, excisionase family BLE401_RS02145 ENOG4105CV1 Transketolase (EC 2.2.1.1) BLE401_RS02155 ENOG4105BZU Histidine kinase BLE401_RS02185 ENOG4105F4R Transcriptional regulator mode BLE401_RS02190 ENOG4105F4R Transcriptional regulator mode BLE401_RS02200 ENOG4105I9Z UPF0264 protein BLE401_RS02220 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BLE401_RS02230 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) BLE401_RS02240 ENOG4105CCT upf0313 protein BLE401_RS02250 ENOG4108ZG0 Ompa motb domain protein BLE401_RS02255 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BLE401_RS02260 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BLE401_RS02265 ENOG4105CSU acyl-Coa dehydrogenase BLE401_RS02270 ENOG4105C1G acyl-Coa dehydrogenase BLE401_RS02300 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BLE401_RS02310 ENOG4105EAH synthase BLE401_RS02320 ENOG4108KU3 Integrase BLE401_RS02440 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BLE401_RS02460 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BLE401_RS02465 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BLE401_RS02475 ENOG4105FQ6 thiopurine methyltransferase BLE401_RS02480 ENOG4105NWN ApaG protein BLE401_RS02485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BLE401_RS02490 ENOG4107S7U Sulfide dehydrogenase BLE401_RS02500 ENOG4105CHR reductase BLE401_RS02510 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BLE401_RS02515 ENOG4105BZU Histidine kinase BLE401_RS02535 ENOG4105BZU Histidine kinase BLE401_RS02545 ENOG4105W53 bacterioferritin-associated ferredoxin BLE401_RS02565 ENOG4105VN1 Heat shock protein BLE401_RS02575 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BLE401_RS02580 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BLE401_RS02595 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase BLE401_RS02600 ENOG4108K5P (LipO)protein BLE401_RS02620 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BLE401_RS02625 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BLE401_RS02650 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BLE401_RS02655 ENOG4105CFH Aspartokinase BLE401_RS02680 ENOG4108Z7G MaoC domain protein dehydratase BLE401_RS02685 ENOG4105CH7 arginosuccinase BLE401_RS02695 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BLE401_RS02700 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BLE401_RS02705 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BLE401_RS02710 ENOG4105DKB L-sorbosone dehydrogenase BLE401_RS02720 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) BLE401_RS02725 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BLE401_RS02730 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BLE401_RS02735 ENOG4105DN3 alpha-2-macroglobulin domain protein BLE401_RS02740 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) BLE401_RS02750 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for BLE401_RS02765 ENOG4107QN1 sodium solute BLE401_RS02790 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BLE401_RS02795 ENOG4105CP7 Triose-phosphate isomerase BLE401_RS02800 ENOG4105NTZ Preprotein translocase subunit SecG BLE401_RS02805 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BLE401_RS02810 ENOG4105BZU Histidine kinase BLE401_RS02815 ENOG4107Z5C methylesterase BLE401_RS02825 ENOG4105CP9 extracellular ligand-binding receptor BLE401_RS02850 ENOG4105CSA Coproporphyrinogen iii oxidase BLE401_RS02890 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) BLE401_RS02895 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) BLE401_RS02905 ENOG4105CAS nag kinase BLE401_RS02910 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BLE401_RS02925 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) BLE401_RS02930 ENOG4105CBC glutamate synthase BLE401_RS02940 ENOG4105DSY exodeoxyribonuclease V, gamma BLE401_RS02950 ENOG41062IR nudix hydrolase BLE401_RS02955 ENOG4105CVM Molybdenum cofactor synthesis domain protein BLE401_RS02970 ENOG4105E6M Sulphatase-modifying factor protein BLE401_RS03000 ENOG4105UYK outer membrane protein a BLE401_RS03005 ENOG4105E6M Sulphatase-modifying factor protein BLE401_RS03010 ENOG4105C8Q Methyl-accepting chemotaxis BLE401_RS03030 ENOG4105BZU Histidine kinase BLE401_RS03040 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BLE401_RS03050 ENOG4107X2D transcriptional regulator, merr family BLE401_RS03055 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BLE401_RS03070 ENOG4105C8Q Methyl-accepting chemotaxis BLE401_RS03080 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) BLE401_RS03090 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BLE401_RS03095 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BLE401_RS03115 ENOG4105CHC glucokinase (EC 2.7.1.2) BLE401_RS03135 ENOG41082RQ UPF0102 protein BLE401_RS03145 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BLE401_RS03150 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BLE401_RS03155 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BLE401_RS03165 ENOG4108URH decarboxylase BLE401_RS03170 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BLE401_RS03175 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BLE401_RS03195 ENOG4105BZU Histidine kinase BLE401_RS03210 ENOG4105E4C Lytic transglycosylase catalytic BLE401_RS03220 ENOG4105BZU Histidine kinase BLE401_RS03240 ENOG4107QKZ Ompa motb domain protein BLE401_RS03260 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) BLE401_RS03285 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BLE401_RS03300 ENOG4105C7S Dehydrogenase BLE401_RS03305 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BLE401_RS03315 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BLE401_RS03320 ENOG4105CDU Replicative dna helicase BLE401_RS03325 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BLE401_RS03330 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BLE401_RS03335 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BLE401_RS03340 ENOG4108UKZ OsmC family BLE401_RS03345 ENOG4105CRK lysyL-tRNA synthetase BLE401_RS03350 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BLE401_RS03360 ENOG4105CHU acetyl-coa acetyltransferase BLE401_RS03365 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BLE401_RS03375 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN BLE401_RS03380 ENOG4108UR2 Nitrogen fixation protein NifX BLE401_RS03415 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class BLE401_RS03420 ENOG4105WVQ Fe-S assembly protein IscX BLE401_RS03425 ENOG4105C9U ATP-dependent DNA helicase RecQ BLE401_RS03435 ENOG4105CA0 peroxidase BLE401_RS03460 ENOG4105BZU Histidine kinase BLE401_RS03470 ENOG4107QN2 dihydrolipoyl dehydrogenase BLE401_RS03475 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BLE401_RS03480 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BLE401_RS03485 ENOG4105CZX twitching motility protein BLE401_RS03490 ENOG4105C32 Amino acid ABC transporter (Permease) BLE401_RS03500 ENOG4108F37 ATP-binding component of a transport system BLE401_RS03520 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BLE401_RS03530 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BLE401_RS03535 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BLE401_RS03550 ENOG4105DP0 ferredoxin-NADP reductase BLE401_RS03560 ENOG4105BZU Histidine kinase BLE401_RS03565 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BLE401_RS03570 ENOG41083WG hydrogenase assembly chaperone BLE401_RS03580 ENOG4105BZ8 glutamate synthase BLE401_RS03585 ENOG4105CBC glutamate synthase BLE401_RS03590 ENOG4105D9M gamma-glutamylcysteine synthetase BLE401_RS03595 ENOG4107QRG dna polymerase iii BLE401_RS03610 ENOG4105MYN Zinc uptake regulation protein BLE401_RS03620 ENOG4108JUA Transcriptional regulator BLE401_RS03625 ENOG4105DS4 PAS PAC sensor Signal transduction histidine kinase BLE401_RS03630 ENOG4105VDB UPF0125 protein BLE401_RS03635 ENOG4108E8M Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BLE401_RS03640 ENOG4108UQQ Electron transport complex BLE401_RS03645 ENOG4105D6A Electron transport complex BLE401_RS03650 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BLE401_RS03655 ENOG4108R3D Electron transport complex BLE401_RS03660 ENOG4105DGN Electron transport complex BLE401_RS03670 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BLE401_RS03675 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BLE401_RS03680 ENOG4105DZB Electron transport complex BLE401_RS03685 ENOG4108VAU general secretion pathway protein G BLE401_RS03715 ENOG4108TEB UPF0114 protein BLE401_RS03725 ENOG4105D7Q type ii secretion system BLE401_RS03740 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) BLE401_RS03745 ENOG4105D0B Nitrogenase protein alpha chain BLE401_RS03750 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain BLE401_RS03755 ENOG41084IN nitrogen fixation protein BLE401_RS03760 ENOG4105FZE dinitrogenase iron-molybdenum cofactor biosynthesis BLE401_RS03770 ENOG4108TGK Low-potential electron donor to a number of redox enzymes (By similarity) BLE401_RS03795 ENOG4107RF4 Phosphodiesterase BLE401_RS03800 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BLE401_RS03805 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BLE401_RS03815 ENOG4107RAQ aminopeptidase BLE401_RS03820 ENOG4108IQE Amp-dependent synthetase and ligase BLE401_RS03835 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BLE401_RS03840 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BLE401_RS03850 ENOG4108NEV two component transcriptional regulator, LytTR family BLE401_RS03860 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BLE401_RS03865 ENOG4105EKE dihydroorotase BLE401_RS03880 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BLE401_RS03885 ENOG4105BZS acriflavin resistance protein BLE401_RS03890 ENOG4105DJY efflux transporter, rnd family, mfp subunit BLE401_RS03925 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) BLE401_RS03930 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BLE401_RS03955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BLE401_RS03960 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BLE401_RS03990 ENOG4105D52 delta-aminolevulinic acid dehydratase BLE401_RS04005 ENOG4107QX8 SPFH domain, Band 7 family protein BLE401_RS04010 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BLE401_RS04015 ENOG4105EAC phosphoserine phosphatase BLE401_RS04025 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BLE401_RS04030 ENOG4105CGH 5'-nucleotidase BLE401_RS04050 ENOG4105E89 ABC transporter BLE401_RS04055 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BLE401_RS04065 ENOG41087YS Phage shock protein A BLE401_RS04075 ENOG4105BZU Histidine kinase BLE401_RS04095 ENOG4105D7T ABC transporter BLE401_RS04115 ENOG4105BZU Histidine kinase BLE401_RS04125 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain BLE401_RS04135 ENOG4105C8N cysteinyl-tRNA synthetase BLE401_RS04145 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BLE401_RS04160 ENOG4105BZU Histidine kinase BLE401_RS04165 ENOG4105BZU Histidine kinase BLE401_RS04180 ENOG4105C7B Threonine dehydratase BLE401_RS04200 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BLE401_RS04225 ENOG4105ECY inositol monophosphatase BLE401_RS04230 ENOG4106237 Protein of unknown function (DUF330) BLE401_RS04265 ENOG4105I7R Adenylate cyclase BLE401_RS04275 ENOG4105ETT transcriptional Regulator, LysR family BLE401_RS04285 ENOG4105CZX twitching motility protein BLE401_RS04290 ENOG4105CZX twitching motility protein BLE401_RS04295 ENOG4108IRC dna polymerase iii BLE401_RS04300 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BLE401_RS04305 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BLE401_RS04315 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BLE401_RS04330 ENOG4105BZU Histidine kinase BLE401_RS04335 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein BLE401_RS04340 ENOG4105WH1 Two component transcriptional regulator luxr family BLE401_RS04345 ENOG4105BZU Histidine kinase BLE401_RS04350 ENOG4105DZG Dehydrogenase BLE401_RS04370 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BLE401_RS04380 ENOG4105VTN Protein of unknown function (DUF1311) BLE401_RS04385 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BLE401_RS04440 ENOG4105CMS peptidase U62, modulator of DNA gyrase BLE401_RS04445 ENOG4106R49 Methyltransferase BLE401_RS04450 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BLE401_RS04465 ENOG4105CEN a g-specific adenine glycosylase BLE401_RS04470 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) BLE401_RS04485 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BLE401_RS04490 ENOG4108Z43 UPF0250 protein BLE401_RS04495 ENOG4105F0I Aminotransferase BLE401_RS04505 ENOG4108Z4U Ferredoxin BLE401_RS04510 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BLE401_RS04515 ENOG4105BZU Histidine kinase BLE401_RS04520 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BLE401_RS04535 ENOG4107P5I polyketide synthase BLE401_RS04555 ENOG4108JUA Transcriptional regulator BLE401_RS04560 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BLE401_RS04565 ENOG4105HF0 Membrane BLE401_RS04590 ENOG4108MN8 Membrane BLE401_RS04600 ENOG4105CX6 glutaminyL-tRNA synthetase BLE401_RS04605 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BLE401_RS04635 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class BLE401_RS04640 ENOG4105BZU Histidine kinase BLE401_RS04655 ENOG4105IJJ transcriptional regulator, crp fnr family BLE401_RS04665 ENOG4108Z33 Thiol disulfide Interchange Protein BLE401_RS04670 ENOG4105VDB UPF0125 protein BLE401_RS04675 ENOG4108Z1B Cyclase dehydrase BLE401_RS04680 ENOG4105C0B DNA polymerase III (alpha subunit) BLE401_RS04695 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BLE401_RS04705 ENOG4108JJ7 ABC transporter BLE401_RS04720 ENOG4108USZ hydrogenase BLE401_RS04730 ENOG4105E3S small subunit BLE401_RS04765 ENOG4105CB5 ATP-dependent DNA helicase recG BLE401_RS04800 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BLE401_RS04805 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BLE401_RS04815 ENOG4105CDY transcriptional regulatory protein BLE401_RS04820 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BLE401_RS04830 ENOG4105BZU Histidine kinase BLE401_RS04835 ENOG4108SHN Glycosyl transferase, family 2 BLE401_RS04840 ENOG4107YYJ Glycosyl transferase, family 2 BLE401_RS04845 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BLE401_RS04850 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BLE401_RS04855 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BLE401_RS04860 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BLE401_RS04865 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ BLE401_RS04870 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BLE401_RS04875 ENOG41076E6 Uroporphyrinogen-III Synthase BLE401_RS04885 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BLE401_RS04890 ENOG4105C2X Arabinose 5-phosphate isomerase BLE401_RS04895 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BLE401_RS04910 ENOG4105D6S protein involved in catabolism of external DNA BLE401_RS04920 ENOG4108VYJ response regulator receiver protein BLE401_RS04925 ENOG4105CBS Chea signal transduction histidine kinase BLE401_RS04930 ENOG4108V3W Chemotaxis protein, CheW BLE401_RS04935 ENOG4107TUY Histidine kinase BLE401_RS04940 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BLE401_RS04965 ENOG4107QIJ Aconitate hydratase 2 BLE401_RS04975 ENOG4105E3B Multicopper oxidase BLE401_RS04985 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 BLE401_RS04990 ENOG4105CV6 ABC transporter, permease BLE401_RS04995 ENOG4108I0Y (ABC) transporter BLE401_RS05000 ENOG4108UJV acyl-CoA thioesterase i BLE401_RS05015 ENOG4107VGR Catalase BLE401_RS05020 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BLE401_RS05030 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BLE401_RS05035 ENOG4105BZU Histidine kinase BLE401_RS05040 ENOG4107QR9 Iron-sulfur cluster binding protein BLE401_RS05045 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BLE401_RS05050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BLE401_RS05055 ENOG4108IRC dna polymerase iii BLE401_RS05065 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) BLE401_RS05085 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BLE401_RS05100 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BLE401_RS05105 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BLE401_RS05130 ENOG4105BZU Histidine kinase BLE401_RS05160 ENOG4105BZU Histidine kinase BLE401_RS05165 ENOG4105BZU Histidine kinase BLE401_RS05185 ENOG4105DHT Metal Dependent Phosphohydrolase BLE401_RS05190 ENOG4108UJV acyl-CoA thioesterase i BLE401_RS05195 ENOG4105BZU Histidine kinase BLE401_RS05200 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 BLE401_RS05205 ENOG4108VUY thioesterase Superfamily protein BLE401_RS05210 ENOG4105BZU Histidine kinase BLE401_RS05215 ENOG4105BZU Histidine kinase BLE401_RS05225 ENOG4105M2J Glutaredoxin BLE401_RS05275 ENOG4105F8C transglutaminase domain-containing protein BLE401_RS05285 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) BLE401_RS05290 ENOG4105EU8 FAD linked oxidase domain protein BLE401_RS05295 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BLE401_RS05320 ENOG4105DY2 Paraquat-inducible protein b BLE401_RS05325 ENOG4105F1S paraquat-inducible protein a BLE401_RS05330 ENOG4105X5Z General secretion pathway protein I BLE401_RS05355 ENOG4107VRP DNA repair exonuclease BLE401_RS05360 ENOG4105BZU Histidine kinase BLE401_RS05375 ENOG4105SYT Methylenetetrahydrofolate reductase BLE401_RS05435 ENOG4108V5Q transglutaminase-like protein BLE401_RS05440 ENOG4106F1P AAA ATPase, central domain protein BLE401_RS05445 ENOG4105FE9 pseudouridine synthase BLE401_RS05455 ENOG4108Q5Y Membrane BLE401_RS05465 ENOG4105DGW oligopeptidase A BLE401_RS05475 ENOG4105CJ1 ABC, transporter BLE401_RS05495 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BLE401_RS05540 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) BLE401_RS05555 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BLE401_RS05570 ENOG4105M6F mutator MutT protein BLE401_RS05575 ENOG4107QHF type ii secretion system protein e BLE401_RS05585 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BLE401_RS05590 ENOG4105CGK Exodeoxyribonuclease III BLE401_RS05595 ENOG4106932 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BLE401_RS05600 ENOG4105CJN penicillin-binding protein BLE401_RS05605 ENOG4105CQ7 ATP-dependent helicase BLE401_RS05615 ENOG4105MRR Transcriptional regulator (By similarity) BLE401_RS05625 ENOG4105BZU Histidine kinase BLE401_RS05630 ENOG4105HDK L-asparaginase BLE401_RS05635 ENOG4105C59 p-type ATPase BLE401_RS05665 ENOG4105XFK Ferrous iron transport protein A BLE401_RS05685 ENOG4105Y75 tpr repeat protein BLE401_RS05705 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BLE401_RS05790 ENOG4105C5H ABC transporter BLE401_RS05820 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BLE401_RS05835 ENOG4105CN1 protease BLE401_RS05840 ENOG41063SB peptidase BLE401_RS05900 ENOG4105IQ5 FAD linked oxidase domain protein BLE401_RS05915 ENOG4105C12 Phosphoribosylglycinamide synthetase BLE401_RS05920 ENOG4105DC1 bifunctional purine biosynthesis protein purh BLE401_RS05925 ENOG4105BZU Histidine kinase BLE401_RS05975 ENOG4105C0D helicase BLE401_RS06000 ENOG4108JA2 transcriptioN-repair coupling factor BLE401_RS06015 ENOG4105DHT Metal Dependent Phosphohydrolase BLE401_RS06025 ENOG4105KME endoribonuclease L-psp BLE401_RS06030 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) BLE401_RS06045 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i BLE401_RS06055 ENOG4105C59 p-type ATPase BLE401_RS06060 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) BLE401_RS06070 ENOG4105C2N RNA methyltransferase TrmH family group 3 BLE401_RS06085 ENOG4105WAP TPR repeat-containing protein BLE401_RS06105 ENOG4108IV0 ABC, transporter BLE401_RS06110 ENOG4105CKI cobalamin synthesis protein BLE401_RS06150 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BLE401_RS06160 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BLE401_RS06165 ENOG41067CV Integrase BLE401_RS06170 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BLE401_RS06180 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BLE401_RS06185 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BLE401_RS06195 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BLE401_RS06210 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BLE401_RS06215 ENOG4105CI3 gtp-binding protein typa BLE401_RS06220 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BLE401_RS06225 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BLE401_RS06235 ENOG4105BZU Histidine kinase BLE401_RS06245 ENOG4105C4X radical SAM domain protein BLE401_RS06250 ENOG4105BZU Histidine kinase BLE401_RS06255 ENOG4108Z66 YbaK ebsC protein BLE401_RS06260 ENOG4105BZ1 (ABC) transporter BLE401_RS06265 ENOG4108V0P LemA family BLE401_RS06270 ENOG4105F8V Hydrolase, tatD family BLE401_RS06275 ENOG4105CUZ uba thif-type nad fad binding protein BLE401_RS06280 ENOG4105BZU Histidine kinase BLE401_RS06285 ENOG4105BZU Histidine kinase BLE401_RS06295 ENOG4105NI8 Cytosine-specific methyltransferase BLE401_RS06305 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BLE401_RS06310 ENOG4105DWY Agmatine deiminase BLE401_RS06325 ENOG4105CQB FAD linked oxidase domain protein BLE401_RS06335 ENOG4105KHU inner membrane protein YohD BLE401_RS06350 ENOG4105C5H ABC transporter BLE401_RS06360 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 BLE401_RS06370 ENOG4105C26 Dehydrogenase BLE401_RS06380 ENOG4105BZU Histidine kinase BLE401_RS06385 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BLE401_RS06415 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BLE401_RS06420 ENOG4107YD3 Thioesterase BLE401_RS06425 ENOG4105E02 MotA TolQ exbB proton channel BLE401_RS06430 ENOG4105M8F Biopolymer transport protein exbD tolR BLE401_RS06440 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BLE401_RS06445 ENOG4105KCK Peptidoglycan-associated lipoprotein BLE401_RS06455 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BLE401_RS06465 ENOG4108WIW Aspartyl protease BLE401_RS06470 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BLE401_RS06475 ENOG4105E4C Lytic transglycosylase catalytic BLE401_RS06490 ENOG4105E0X reductase BLE401_RS06515 ENOG4105C3J Cysteine desulfurase BLE401_RS06520 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BLE401_RS06525 ENOG4105QAS Iron-sulfur cluster assembly accessory protein BLE401_RS06550 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BLE401_RS06555 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BLE401_RS06560 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BLE401_RS06565 ENOG4105K59 histidine triad (HIT) protein BLE401_RS06570 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase BLE401_RS06580 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BLE401_RS06590 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BLE401_RS06595 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BLE401_RS06620 ENOG4105ED9 Protein of unknown function (DUF455) BLE401_RS06645 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BLE401_RS06650 ENOG4105EIF outer membrane protein W BLE401_RS06655 ENOG4105BZU Histidine kinase BLE401_RS06660 ENOG4105C9X ppx gppa phosphatase BLE401_RS06675 ENOG4105CPC Aldo Keto reductase BLE401_RS06700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BLE401_RS06710 ENOG4105D64 Mechanosensitive ion channel BLE401_RS06715 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BLE401_RS06735 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BLE401_RS06765 ENOG4108IAB Phoh family BLE401_RS06770 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BLE401_RS06775 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BLE401_RS06780 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BLE401_RS06795 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BLE401_RS06800 ENOG4105GJM (LipO)protein BLE401_RS06810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BLE401_RS06815 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) BLE401_RS06820 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BLE401_RS06830 ENOG4107QJE Chromosome Partitioning Protein BLE401_RS06835 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BLE401_RS06840 ENOG4105BZU Histidine kinase BLE401_RS06860 ENOG4106D4I domain protein BLE401_RS06865 ENOG41077A9 carbonic anhydrase BLE401_RS06870 ENOG4108151 Beta-lactamase domain protein BLE401_RS06910 ENOG4105D78 K07001 NTE family protein BLE401_RS06915 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BLE401_RS06935 ENOG4105C1G acyl-Coa dehydrogenase BLE401_RS06945 ENOG4105CVR type I restriction-modification system BLE401_RS06950 ENOG4105EKX Restriction modification system DNA (Specificity BLE401_RS06955 ENOG4105DZR Type I site-specific deoxyribonuclease BLE401_RS06960 ENOG4105DZG Dehydrogenase BLE401_RS06970 ENOG4105EAB amino acid AbC transporter BLE401_RS06985 ENOG4108IPJ Membrane BLE401_RS06995 ENOG4105UBK short-chain dehydrogenase reductase BLE401_RS07000 ENOG4105BZU Histidine kinase BLE401_RS07010 ENOG4105BZU Histidine kinase BLE401_RS07020 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BLE401_RS07050 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BLE401_RS07055 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BLE401_RS07060 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BLE401_RS07070 ENOG4105ES5 Histidine kinase BLE401_RS07075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BLE401_RS07080 ENOG4105C1A potassium transporter peripheral membrane BLE401_RS07095 ENOG4105C8Q Methyl-accepting chemotaxis BLE401_RS07115 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein BLE401_RS07120 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) BLE401_RS07125 ENOG41082J7 Rhodanese domain protein BLE401_RS07130 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BLE401_RS07155 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BLE401_RS07160 ENOG41083VT K03651 Icc protein BLE401_RS07165 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase BLE401_RS07180 ENOG4105E3W Two component transcriptional regulator (Winged helix family BLE401_RS07185 ENOG4105EB3 Histidine kinase BLE401_RS07190 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BLE401_RS07195 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BLE401_RS07200 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BLE401_RS07215 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) BLE401_RS07250 ENOG4105H1G trap transporter solute receptor taxi family BLE401_RS07280 ENOG4107SGM protein serine threonine phosphatase BLE401_RS07290 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BLE401_RS07310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BLE401_RS07315 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BLE401_RS07325 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BLE401_RS07335 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BLE401_RS07345 ENOG41081M5 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BLE401_RS07350 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein BLE401_RS07355 ENOG4105C87 Aminotransferase class I and II BLE401_RS07365 ENOG4105C5X domain protein BLE401_RS07370 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E BLE401_RS07375 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d BLE401_RS07380 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) BLE401_RS07405 ENOG4105CJ1 ABC, transporter BLE401_RS07410 ENOG4105D07 Signal peptide peptidase, SppA BLE401_RS07420 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BLE401_RS07430 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BLE401_RS07435 ENOG4105BZ4 penicillin-binding protein BLE401_RS07450 ENOG4105VEJ Heat shock protein BLE401_RS07455 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BLE401_RS07470 ENOG4105BZS acriflavin resistance protein BLE401_RS07475 ENOG4105ENT Efflux transporter rnd family, mfp subunit BLE401_RS07480 ENOG4108URH decarboxylase BLE401_RS07505 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BLE401_RS07510 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BLE401_RS07515 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BLE401_RS07520 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BLE401_RS07525 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BLE401_RS07530 ENOG4108SHN Glycosyl transferase, family 2 BLE401_RS07535 ENOG4105BZU Histidine kinase BLE401_RS07540 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BLE401_RS07575 ENOG4105CH5 extracellular solute-binding protein, family 7 BLE401_RS07590 ENOG4105DZR Type I site-specific deoxyribonuclease BLE401_RS07610 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BLE401_RS07615 ENOG4107QI6 Cysteine desulfurase BLE401_RS07620 ENOG4105C3J Cysteine desulfurase BLE401_RS07625 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BLE401_RS07635 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BLE401_RS07640 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BLE401_RS07650 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BLE401_RS07655 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BLE401_RS07660 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BLE401_RS07700 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BLE401_RS07705 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BLE401_RS07710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BLE401_RS07715 ENOG4105CUX Signal transduction histidine kinase BLE401_RS07720 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BLE401_RS07725 ENOG4105MA0 exported protein BLE401_RS07760 ENOG4105DCF alanine dehydrogenase BLE401_RS07775 ENOG4105KTH gatB Yqey BLE401_RS07780 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BLE401_RS07785 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BLE401_RS07795 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BLE401_RS07800 ENOG4108IUZ ABC transporter BLE401_RS07805 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BLE401_RS07810 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA BLE401_RS07815 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BLE401_RS07820 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BLE401_RS07835 ENOG4105C25 Primosomal protein n' BLE401_RS07840 ENOG4105BZU Histidine kinase BLE401_RS07845 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BLE401_RS07850 ENOG4105C34 Pseudouridine synthase BLE401_RS07865 ENOG4105BZU Histidine kinase BLE401_RS07870 ENOG4105C3G gtp-binding protein BLE401_RS07875 ENOG4105F0R Cytidylyltransferase BLE401_RS07885 ENOG4105D2T synthase BLE401_RS07890 ENOG4107V9E glucose-1-phosphate thymidylyltransferase BLE401_RS07895 ENOG4105F0N pyrophosphate phospho-hydrolase BLE401_RS07900 ENOG4105DBV ornithine carbamoyltransferase BLE401_RS07905 ENOG4105C8Y Acetylornithine aminotransferase BLE401_RS07910 ENOG4105UYK outer membrane protein a BLE401_RS07915 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BLE401_RS07920 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BLE401_RS07925 ENOG4105BZU Histidine kinase BLE401_RS07940 ENOG4105C26 Dehydrogenase BLE401_RS07955 ENOG4105DS1 cytochrome b561 BLE401_RS07975 ENOG4108ZG0 Ompa motb domain protein BLE401_RS07980 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BLE401_RS08000 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BLE401_RS08005 ENOG4105BZA Phosphoglycerate kinase BLE401_RS08010 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BLE401_RS08015 ENOG4105CHM Aminotransferase BLE401_RS08020 ENOG4105C0D helicase BLE401_RS08030 ENOG4105EEX Two component transcriptional regulator (Winged helix family BLE401_RS08035 ENOG4105C08 Histidine kinase BLE401_RS08040 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BLE401_RS08045 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BLE401_RS08050 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BLE401_RS08060 ENOG4105C31 Tryptophanyl-tRNA synthetase BLE401_RS08080 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BLE401_RS08090 ENOG4108V1T peptidylprolyl cis-trans isomerase BLE401_RS08095 ENOG4105DVT helicase BLE401_RS08100 ENOG4108YZA Nitrogen regulatory protein pii BLE401_RS08110 ENOG4105BZU Histidine kinase BLE401_RS08125 ENOG4105CHC glucokinase (EC 2.7.1.2) BLE401_RS08130 ENOG4105D06 uba thif-type nad fad binding protein BLE401_RS08145 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BLE401_RS08150 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BLE401_RS08160 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) BLE401_RS08165 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BLE401_RS08170 ENOG4105CUT histidyl-tRNA synthetase BLE401_RS08175 ENOG4105N21 Membrane BLE401_RS08180 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BLE401_RS08185 ENOG4105BZU Histidine kinase BLE401_RS08190 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BLE401_RS08200 ENOG4105CXB phosphoribosylaminoimidazole synthetase BLE401_RS08205 ENOG4108V3E phosphoribosylglycinamide formyltransferase BLE401_RS08210 ENOG4105EUJ GTP cyclohydrolase i BLE401_RS08220 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP BLE401_RS08235 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BLE401_RS08240 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BLE401_RS08250 ENOG4105EPW hflc protein BLE401_RS08255 ENOG4107QJR hflk protein BLE401_RS08275 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BLE401_RS08280 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BLE401_RS08285 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BLE401_RS08290 ENOG4105D7Q type ii secretion system BLE401_RS08300 ENOG4105C4R Atp-dependent dna helicase BLE401_RS08305 ENOG41087AY ADP-Ribose pyrophosphatase BLE401_RS08315 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BLE401_RS08325 ENOG4107YZP Rhodanese domain protein BLE401_RS08330 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BLE401_RS08335 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BLE401_RS08345 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BLE401_RS08355 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase BLE401_RS08390 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BLE401_RS08395 ENOG4105K63 Thioredoxin BLE401_RS08405 ENOG4108VAU general secretion pathway protein G BLE401_RS08410 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BLE401_RS08435 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BLE401_RS08440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BLE401_RS08450 ENOG41067MG lrgb family BLE401_RS08455 ENOG4105VAW lrga family BLE401_RS08465 ENOG4105BZU Histidine kinase BLE401_RS08470 ENOG4107S0N DJ-1 family BLE401_RS08490 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit BLE401_RS08495 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BLE401_RS08500 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BLE401_RS08515 ENOG4108K5P (LipO)protein BLE401_RS08520 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BLE401_RS08525 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BLE401_RS08530 ENOG4108S0S Nucleotidyl transferase BLE401_RS08550 ENOG41060IM Heme exporter protein BLE401_RS08555 ENOG4105X3C heme exporter protein BLE401_RS08560 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) BLE401_RS08565 ENOG4105DA4 cytochrome c-type biogenesis protein BLE401_RS08575 ENOG4105C59 p-type ATPase BLE401_RS08585 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BLE401_RS08590 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BLE401_RS08595 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BLE401_RS08600 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BLE401_RS08610 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BLE401_RS08630 ENOG4108I0Q anthranilate phosphoribosyltransferase BLE401_RS08635 ENOG41081QV Universal stress protein BLE401_RS08645 ENOG41089BK Glutamine amido-transferase BLE401_RS08650 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BLE401_RS08655 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BLE401_RS08660 ENOG4108TPP exopolysaccharide synthesis BLE401_RS08670 ENOG4105E4C Lytic transglycosylase catalytic BLE401_RS08685 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BLE401_RS08690 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class BLE401_RS08695 ENOG4105E6M Sulphatase-modifying factor protein BLE401_RS08705 ENOG4105C7I Dehydrogenase BLE401_RS08710 ENOG4105C8U phosphate abc transporter BLE401_RS08715 ENOG4105C8U phosphate abc transporter BLE401_RS08720 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BLE401_RS08730 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BLE401_RS08745 ENOG4105C1G acyl-Coa dehydrogenase BLE401_RS08770 ENOG4105D7T ABC transporter BLE401_RS08775 ENOG4108IFG nitrite reductase, (NAD(P)H) BLE401_RS08780 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BLE401_RS08795 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BLE401_RS08805 ENOG4105FE1 phytoene synthase BLE401_RS08810 ENOG4107QX8 SPFH domain, Band 7 family protein BLE401_RS08825 ENOG4108P4C Formaldehyde-activating enzyme BLE401_RS08840 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BLE401_RS08845 ENOG4108Z0Z intracellular protease Pfpi family BLE401_RS08865 ENOG4105K4H Nlp p60 protein BLE401_RS08870 ENOG4105D3R alkyl hydroperoxide reductase BLE401_RS08895 ENOG4105DFA alanine racemase domain protein BLE401_RS08900 ENOG4105K4P CoA-binding domain protein BLE401_RS08930 ENOG4107QP8 phosphohexose isomerase BLE401_RS08950 ENOG4107QTF adenylosuccinate lyase BLE401_RS08955 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BLE401_RS08960 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BLE401_RS08980 ENOG4105BZU Histidine kinase BLE401_RS08995 ENOG4105BZU Histidine kinase BLE401_RS09020 ENOG4108IAJ Nad-dependent epimerase dehydratase BLE401_RS09025 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BLE401_RS09045 ENOG4105BZS acriflavin resistance protein BLE401_RS09060 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BLE401_RS09065 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BLE401_RS09070 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BLE401_RS09075 ENOG4105DJ0 Poly(A) Polymerase BLE401_RS09085 ENOG4105CG5 Glycosyl transferase (Group 1 BLE401_RS09090 ENOG4105CAQ asparagine synthetase BLE401_RS09095 ENOG4105CKK Glycosyl transferase, family 2 BLE401_RS09105 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BLE401_RS09115 ENOG4105BZU Histidine kinase BLE401_RS09120 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BLE401_RS09125 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BLE401_RS09130 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BLE401_RS09135 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BLE401_RS09140 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BLE401_RS09150 ENOG4107QIZ NADH dehydrogenase BLE401_RS09155 ENOG4108IEH NADH dehydrogenase subunit g BLE401_RS09160 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BLE401_RS09165 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BLE401_RS09175 ENOG4105DF2 NADH dehydrogenase subunit j BLE401_RS09180 ENOG41080FQ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BLE401_RS09190 ENOG4105C8S subunit m BLE401_RS09195 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BLE401_RS09200 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BLE401_RS09205 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate BLE401_RS09210 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) BLE401_RS09230 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BLE401_RS09240 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) BLE401_RS09245 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BLE401_RS09250 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BLE401_RS09255 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BLE401_RS09260 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BLE401_RS09265 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BLE401_RS09270 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BLE401_RS09275 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BLE401_RS09280 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BLE401_RS09295 ENOG4105K5B UPF0225 protein BLE401_RS09300 ENOG4105CY3 ABC transporter, permease BLE401_RS09305 ENOG4105DHJ ABC, transporter BLE401_RS09315 ENOG4105BZU Histidine kinase BLE401_RS09330 ENOG4105D0M Protease HtpX homolog BLE401_RS09340 ENOG4105E6M Sulphatase-modifying factor protein BLE401_RS09570 ENOG4108WTW DNA transposition protein BLE401_RS09575 ENOG4106YXT transposase BLE401_RS09615 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BLE401_RS09640 ENOG4108HRK Histidine kinase BLE401_RS09665 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BLE401_RS09670 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BLE401_RS09675 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BLE401_RS09680 ENOG4108VZM 50s ribosomal protein L10 BLE401_RS09685 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BLE401_RS09690 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BLE401_RS09700 ENOG4105PM1 preprotein translocase subunit SecE BLE401_RS09710 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BLE401_RS09730 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BLE401_RS09740 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BLE401_RS09760 ENOG4108UN4 phage SPO1 DNA polymerase-related protein BLE401_RS09810 ENOG4108KDI dmso reductase anchor subunit BLE401_RS09815 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BLE401_RS09820 ENOG4105DB1 molybdopterin oxidoreductase BLE401_RS09825 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BLE401_RS09835 ENOG4105E6M Sulphatase-modifying factor protein BLE401_RS09860 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BLE401_RS09875 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BLE401_RS09900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BLE401_RS09910 ENOG4105E4G Type IV pilus BLE401_RS09935 ENOG4108JQC penicillin-binding protein 1A BLE401_RS09940 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BLE401_RS09965 ENOG4105CKI cobalamin synthesis protein BLE401_RS09970 ENOG4105DUM transcriptional regulator, lysR family BLE401_RS09975 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BLE401_RS09980 ENOG4108RTD type II secretion system protein K BLE401_RS09985 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 BLE401_RS09995 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BLE401_RS10000 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BLE401_RS10005 ENOG4105EIX cytochrome c1 BLE401_RS10010 ENOG4105KB2 stringent starvation protein b BLE401_RS10025 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BLE401_RS10030 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) BLE401_RS10035 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BLE401_RS10045 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BLE401_RS10050 ENOG4106KVJ cytochrome C assembly protein BLE401_RS10065 ENOG4105CJN penicillin-binding protein BLE401_RS10070 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BLE401_RS10075 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BLE401_RS10080 ENOG4105CHU acetyl-coa acetyltransferase BLE401_RS10090 ENOG4105CHR reductase BLE401_RS10120 ENOG4105CRQ synthase (Component I) BLE401_RS10125 ENOG4105DDQ anthranilate synthase BLE401_RS10130 ENOG4107QHF type ii secretion system protein e BLE401_RS10145 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BLE401_RS10150 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) BLE401_RS10155 ENOG4108UNF response regulator BLE401_RS10160 ENOG4108UNF response regulator BLE401_RS10170 ENOG4108ZGA chew protein BLE401_RS10175 ENOG4105C8Q Methyl-accepting chemotaxis BLE401_RS10210 ENOG4105D0A hydroxylase BLE401_RS10220 ENOG4105CFG Acts as a chaperone (By similarity) BLE401_RS10230 ENOG4105K4H Nlp p60 protein BLE401_RS10240 ENOG41090MY MarR family Transcriptional regulator BLE401_RS10245 ENOG4105W3S hemerythrin-like, metal-binding protein BLE401_RS10255 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BLE401_RS10260 ENOG41082J7 Rhodanese domain protein BLE401_RS10265 ENOG4105DFG type I secretion outer membrane protein BLE401_RS10270 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BLE401_RS10290 ENOG4105DWV Homoserine O-trans-acetylase BLE401_RS10295 ENOG4105DWV Homoserine O-trans-acetylase BLE401_RS10305 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BLE401_RS10310 ENOG4105VFB Binds the 23S rRNA (By similarity) BLE401_RS10335 ENOG4107RJX Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BLE401_RS10340 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BLE401_RS10345 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BLE401_RS10350 ENOG4105CFG Acts as a chaperone (By similarity) BLE401_RS10355 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BLE401_RS10360 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BLE401_RS10375 ENOG4105CGK Exodeoxyribonuclease III BLE401_RS10380 ENOG4105EHM Aminoglycoside phosphotransferase BLE401_RS10385 ENOG4107EFQ arachidonate 15-lipoxygenase BLE401_RS10395 ENOG4105BZU Histidine kinase BLE401_RS10405 ENOG4107QMP dna polymerase iii subunits gamma and tau BLE401_RS10420 ENOG4108Z0R Transferase BLE401_RS10425 ENOG4105CWC Acetylornithine deacetylase BLE401_RS10430 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BLE401_RS10440 ENOG4105W2Z cytochrome C, class I BLE401_RS10445 ENOG4105GVR general secretion pathway protein D BLE401_RS10485 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BLE401_RS10490 ENOG4105D8G Major Facilitator superfamily BLE401_RS10505 ENOG4106WTF Glycosyl transferase, family 2 BLE401_RS10510 ENOG4105XQ6 frataxin-like protein BLE401_RS10525 ENOG4105E1F short-chain dehydrogenase reductase BLE401_RS10535 ENOG4105FAE von Willebrand factor, type A BLE401_RS10555 ENOG4105ERG peptidase m48, ste24p BLE401_RS10580 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BLE401_RS10595 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BLE401_RS10610 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BLE401_RS10640 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BLE401_RS10655 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BLE401_RS10660 ENOG4108IEG Formate dehydrogenase Alpha subunit BLE401_RS10665 ENOG4107QIZ NADH dehydrogenase BLE401_RS10670 ENOG4105GKE subunit e BLE401_RS10685 ENOG4105DFH Transport of potassium into the cell (By similarity) BLE401_RS10700 ENOG4105F8V Hydrolase, tatD family BLE401_RS10705 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BLE401_RS10710 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BLE401_RS10715 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BLE401_RS10720 ENOG4106F1P AAA ATPase, central domain protein BLE401_RS10740 ENOG4105NZG Ferredoxin BLE401_RS10755 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) BLE401_RS10815 ENOG4105C1J atp-dependent rna helicase BLE401_RS10825 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BLE401_RS10840 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BLE401_RS10845 ENOG4105D60 lipoprotein releasing system transmembrane protein BLE401_RS10850 ENOG4108Z0R Transferase BLE401_RS10865 ENOG4105DA5 (ABC) transporter BLE401_RS10870 ENOG4105E3A (ABC) transporter BLE401_RS10875 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BLE401_RS10880 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BLE401_RS10885 ENOG4105VIE preprotein translocase, subunit YajC BLE401_RS10905 ENOG41060WC Enoyl-CoA hydratase BLE401_RS10925 ENOG4105EY8 ABC transporter BLE401_RS10940 ENOG4105CRP Part of the ABC transporter FtsEX involved in BLE401_RS10950 ENOG4105W5Q DNA repair protein (RadC BLE401_RS10975 ENOG4105C22 threonyL-tRNA synthetase BLE401_RS10980 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BLE401_RS10985 ENOG41082NX 50s ribosomal protein l35 BLE401_RS10990 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BLE401_RS11000 ENOG4107Z9R response regulator BLE401_RS11015 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BLE401_RS11115 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BLE401_RS11120 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BLE401_RS11125 ENOG4105CQ7 ATP-dependent helicase BLE401_RS11135 ENOG4105CA0 peroxidase BLE401_RS11145 ENOG4107YIM Involved in the transcription termination process (By similarity) BLE401_RS11160 ENOG4105BZU Histidine kinase BLE401_RS11165 ENOG4107YRI Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BLE401_RS11170 ENOG4108IV0 ABC, transporter BLE401_RS11175 ENOG4105C0Z ABC transporter BLE401_RS11180 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BLE401_RS11185 ENOG4105C32 Amino acid ABC transporter (Permease) BLE401_RS11190 ENOG4105NQN cytochrome C BLE401_RS11195 ENOG4105DJY efflux transporter, rnd family, mfp subunit BLE401_RS11200 ENOG4105KKX ATPase associated with various cellular activities aaa_5 BLE401_RS11210 ENOG4105DJ9 glucan biosynthesis protein BLE401_RS11225 ENOG4105DFU Cell wall formation (By similarity) BLE401_RS11230 ENOG4107RZZ dna polymerase iii epsilon subunit BLE401_RS11240 ENOG4105MPD Cytochrome BLE401_RS11250 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BLE401_RS11260 ENOG4105BZU Histidine kinase BLE401_RS11285 ENOG4105DNE Transposase BLE401_RS11305 ENOG4105CSA Coproporphyrinogen iii oxidase BLE401_RS11320 ENOG4108K5H permease YjgP YjgQ family protein BLE401_RS11335 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BLE401_RS11345 ENOG4108V1T peptidylprolyl cis-trans isomerase BLE401_RS11365 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BLE401_RS11375 ENOG4105VF7 tolerance protein BLE401_RS11380 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) BLE401_RS11385 ENOG4107QMS site-determining protein BLE401_RS11390 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BLE401_RS11450 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BLE401_RS11455 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BLE401_RS11470 ENOG4105W0E 50S ribosomal protein L33 BLE401_RS11475 ENOG4105KDC 50s ribosomal protein l28 BLE401_RS11525 ENOG4108HMN Caspase domain BLE401_RS11540 ENOG4105C26 Dehydrogenase BLE401_RS11570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BLE401_RS11590 ENOG4105CIH Imidazole acetol-phosphate transaminase BLE401_RS11610 ENOG4108KU3 Integrase BLE401_RS11680 ENOG41082YX Transcriptional regulator, arsr family BLE401_RS11690 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BLE401_RS11750 ENOG4105C8Q Methyl-accepting chemotaxis BLE401_RS11755 ENOG4108ZGA chew protein BLE401_RS11760 ENOG4105M3Z response regulator BLE401_RS11765 ENOG4108UNF response regulator BLE401_RS11785 ENOG4105BZU Histidine kinase BLE401_RS11805 ENOG4107QIK phosphoribosylformylglycinamidine synthase BLE401_RS11810 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BLE401_RS11820 ENOG4105DAP Nicotinate phosphoribosyltransferase BLE401_RS11825 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BLE401_RS11845 ENOG4108HMN Caspase domain BLE401_RS11875 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BLE401_RS11890 ENOG4105UYK outer membrane protein a BLE401_RS11895 ENOG4105VW4 glutaredoxin 3 BLE401_RS11910 ENOG4107TDF Formate hydrogenlyase subunit 4 BLE401_RS11945 ENOG4105D7Z glutathione synthase BLE401_RS11950 ENOG41067SE Tetr family transcriptional regulator BLE401_RS11955 ENOG410624X efflux transporter, rnd family, mfp subunit BLE401_RS11960 ENOG4105BZS acriflavin resistance protein BLE401_RS11965 ENOG4108JQ5 ABC transporter BLE401_RS11975 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BLE401_RS11985 ENOG410829K Lysine exporter protein (Lyse ygga) BLE401_RS12010 ENOG4105EYU Glutamine amido-transferase BLE401_RS12020 ENOG4108KK1 membrane protein AbrB duplication BLE401_RS12025 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BLE401_RS12030 ENOG4105E3W Two component transcriptional regulator (Winged helix family BLE401_RS12040 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BLE401_RS12045 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BLE401_RS12055 ENOG4105BZM domain protein BLE401_RS12060 ENOG4105BZU Histidine kinase BLE401_RS12070 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BLE401_RS12075 ENOG4105CUJ penicillin amidase BLE401_RS12085 ENOG4105ER2 Ompa motb domain protein BLE401_RS12110 ENOG4108IUW ABC transporter BLE401_RS12140 ENOG4105EQ2 LysR family Transcriptional regulator BLE401_RS12150 ENOG4105DQ4 alcohol dehydrogenase BLE401_RS12180 ENOG4105E0C molybdate abc transporter BLE401_RS12185 ENOG4107QKW extracellular solute-binding protein family 1 BLE401_RS12200 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) BLE401_RS12230 ENOG4105KVH Transcriptional regulator BLE401_RS12235 ENOG4105ECR NmrA family BLE401_RS12270 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BLE401_RS12275 ENOG4105CMR udp-glucose 4-epimerase BLE401_RS12280 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BLE401_RS12285 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BLE401_RS12290 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BLE401_RS12295 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BLE401_RS12330 ENOG4108KU3 Integrase BLE401_RS12340 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BLE401_RS12360 ENOG4107SGM protein serine threonine phosphatase BLE401_RS12375 ENOG4105KJJ Uncharacterized ACR, COG1993 BLE401_RS12380 ENOG4105WMR Protein CrcB homolog BLE401_RS12385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BLE401_RS12390 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BLE401_RS12405 ENOG41085AF Cytochrome BLE401_RS12415 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BLE401_RS12435 ENOG410605C May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) BLE401_RS12440 ENOG4105XV5 nifz family BLE401_RS12450 ENOG4108P4H ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BLE401_RS12455 ENOG41060BG Tetr family transcriptional regulator BLE401_RS12470 ENOG4105BZU Histidine kinase BLE401_RS12490 ENOG4108P9J Phage shock protein A BLE401_RS12505 ENOG4105C0P Mg chelatase subunit ChlI BLE401_RS12510 ENOG4105W0Z cytoplasmic protein BLE401_RS12530 ENOG4107YVC modification (methylase) BLE401_RS12550 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BLE401_RS12555 ENOG4105CNF WD-40 repeat protein BLE401_RS12575 ENOG4105DZS Phenylacetate-CoA ligase BLE401_RS12580 ENOG4108IV0 ABC, transporter BLE401_RS12595 ENOG4105C32 Amino acid ABC transporter (Permease) BLE401_RS12600 ENOG4105C0Z ABC transporter BLE401_RS12605 ENOG4108IQE Amp-dependent synthetase and ligase BLE401_RS12615 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BLE401_RS12625 ENOG4105DEG Vwa containing coxe family protein BLE401_RS12680 ENOG4105BZU Histidine kinase BLE401_RS12685 ENOG4105BZU Histidine kinase BLE401_RS12695 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BLE401_RS12710 ENOG4108IJ6 ABC transporter BLE401_RS12715 ENOG4105ECW sulfate abc transporter BLE401_RS12720 ENOG4108I5D sulfate abc transporter BLE401_RS12725 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BLE401_RS12730 ENOG4105D4P Coproporphyrinogen iii oxidase BLE401_RS12735 ENOG4105D06 uba thif-type nad fad binding protein BLE401_RS12750 ENOG4105CKW Inner membrane protein yedI BLE401_RS12755 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BLE401_RS12760 ENOG4105EI2 Pseudouridine synthase BLE401_RS12790 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) BLE401_RS12800 ENOG4105CAF HipA N-terminal domain protein BLE401_RS12810 ENOG4108JQB penicillin-binding protein 1C BLE401_RS12820 ENOG4105CA0 peroxidase BLE401_RS12825 ENOG4105CD5 CoA-binding domain protein BLE401_RS12830 ENOG4105DIN metallophosphoesterase BLE401_RS12875 ENOG4106H78 methyltransferase BLE401_RS12890 ENOG4105CPC Aldo Keto reductase BLE401_RS12930 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BLE401_RS12935 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BLE401_RS12945 ENOG4105FAV ABC, transporter BLE401_RS12950 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BLE401_RS12960 ENOG4105C75 arginyL-tRNA synthetase BLE401_RS12965 ENOG4105DZ1 carboxypeptidase BLE401_RS12975 ENOG4105CVE Lytic murein transglycosylase BLE401_RS12980 ENOG4105CNI cell division protein FtsW BLE401_RS12985 ENOG4108ZXC Two component transcriptional regulator, luxr family BLE401_RS12995 ENOG4105C6K Malic enzyme BLE401_RS13010 ENOG4105BZU Histidine kinase BLE401_RS13015 ENOG4108EX3 reductase BLE401_RS13035 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BLE401_RS13045 ENOG4108UJD 30S ribosomal protein S9 BLE401_RS13050 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BLE401_RS13055 ENOG4105CQM Urea amidohydrolase subunit alpha BLE401_RS13065 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BLE401_RS13080 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BLE401_RS13090 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BLE401_RS13125 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BLE401_RS13130 ENOG4105MJ2 Competence protein BLE401_RS13135 ENOG4105BZJ Electron transfer flavoprotein BLE401_RS13140 ENOG4105C10 Electron transfer flavoprotein BLE401_RS13155 ENOG4105BZU Histidine kinase BLE401_RS13175 ENOG4105E6M Sulphatase-modifying factor protein BLE401_RS13180 ENOG4105D1U peptidase U62 modulator of DNA gyrase BLE401_RS13195 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BLE401_RS13200 ENOG4105JKW Valine--pyruvate aminotransferase BLE401_RS13220 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BLE401_RS13225 ENOG4108M8S permease YjgP YjgQ family protein BLE401_RS13235 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BLE401_RS13240 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BLE401_RS13255 ENOG4105C79 DNA protecting protein DprA BLE401_RS13260 ENOG4108RPN Protein smg homolog BLE401_RS13275 ENOG4105CAQ asparagine synthetase BLE401_RS13280 ENOG4105CPK Glycosyl transferase (Group 1 BLE401_RS13285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BLE401_RS13290 ENOG4105E3W Two component transcriptional regulator (Winged helix family BLE401_RS13295 ENOG4105EB3 Histidine kinase BLE401_RS13305 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BLE401_RS13310 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BLE401_RS13320 ENOG4105E1F short-chain dehydrogenase reductase BLE401_RS13330 ENOG4105E6M Sulphatase-modifying factor protein BLE401_RS13340 ENOG4105C0I Conserved Protein BLE401_RS13355 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BLE401_RS13360 ENOG4108UQY Iron-storage protein BLE401_RS13370 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BLE401_RS13375 ENOG4107QVM von Willebrand factor, type A BLE401_RS13380 ENOG4108IYU L-aspartate oxidase BLE401_RS13400 ENOG4105DGI Alkaline phosphatase BLE401_RS13405 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BLE401_RS13410 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BLE401_RS13415 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BLE401_RS13425 ENOG4105C2M dna polymerase I BLE401_RS13430 ENOG4107QUV Domain protein BLE401_RS13470 ENOG4107RTD sua5 ycio yrdc ywlc family protein BLE401_RS13475 ENOG4108Z4T Peptidase M50 BLE401_RS13480 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BLE401_RS13485 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BLE401_RS13490 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BLE401_RS13510 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BLE401_RS13515 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BLE401_RS13520 ENOG4105EEI dihydropteroate synthase BLE401_RS13530 ENOG4108JJA ABC, transporter BLE401_RS13535 ENOG4105GVR general secretion pathway protein D BLE401_RS13560 ENOG4105CGH 5'-nucleotidase BLE401_RS13565 ENOG4108HGU Histidine kinase BLE401_RS13580 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BLE401_RS13590 ENOG4105C9M aspartyl-trna synthetase BLE401_RS13615 ENOG4105C0H protease BLE401_RS13620 ENOG4107TF3 peptidylprolyl cis-trans isomerase BLE401_RS13640 ENOG4105K70 DNA-binding protein BLE401_RS13645 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BLE401_RS13650 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BLE401_RS13655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BLE401_RS13660 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BLE401_RS13675 ENOG4105D16 lipopolysaccharide heptosyltransferase i BLE401_RS13685 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BLE401_RS13690 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BLE401_RS13695 ENOG4105BZU Histidine kinase BLE401_RS13710 ENOG4105KHC sulfurtransferase BLE401_RS13735 ENOG4107QKV phosphomannomutase BLE401_RS13740 ENOG4105DS1 cytochrome b561 BLE401_RS13750 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BLE401_RS13755 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BLE401_RS13765 ENOG4105GVR general secretion pathway protein D BLE401_RS13770 ENOG4105D7Q type ii secretion system BLE401_RS13775 ENOG4107QHF type ii secretion system protein e BLE401_RS13785 ENOG4108C66 Inherit from COG: DNA primase BLE401_RS13790 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BLE401_RS13795 ENOG4105CHU acetyl-coa acetyltransferase BLE401_RS13805 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 BLE401_RS13820 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BLE401_RS13825 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BLE401_RS13830 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BLE401_RS13840 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BLE401_RS13845 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BLE401_RS13855 ENOG4105D94 Major Facilitator Superfamily BLE401_RS13860 ENOG4108ZT0 50S ribosomal protein l17 BLE401_RS13865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BLE401_RS13870 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BLE401_RS13875 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BLE401_RS13880 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BLE401_RS13885 ENOG41067V7 50S ribosomal protein L36 BLE401_RS13890 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BLE401_RS13895 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BLE401_RS13900 ENOG4105VPB 50S ribosomal protein L30 BLE401_RS13910 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BLE401_RS13915 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BLE401_RS13925 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BLE401_RS13930 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BLE401_RS13935 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BLE401_RS13940 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BLE401_RS13945 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BLE401_RS13950 ENOG41083MP 50s ribosomal protein l29 BLE401_RS13960 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BLE401_RS13965 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BLE401_RS13970 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BLE401_RS13975 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BLE401_RS13980 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BLE401_RS13985 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BLE401_RS13990 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BLE401_RS13995 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BLE401_RS14000 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BLE401_RS14005 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BLE401_RS14010 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BLE401_RS14015 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BLE401_RS14020 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BLE401_RS14055 ENOG4105DXN mazG family BLE401_RS14070 ENOG4105BZU Histidine kinase BLE401_RS14075 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BLE401_RS14090 ENOG4105CA0 peroxidase BLE401_RS14100 ENOG4107QN1 sodium solute BLE401_RS14105 ENOG41062QD Membrane BLE401_RS14110 ENOG4108UUM single-stranded DNA-binding protein BLE401_RS14115 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BLE401_RS14120 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BLE401_RS14125 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BLE401_RS14130 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BLE401_RS14150 ENOG4105CWC Acetylornithine deacetylase BLE401_RS14180 ENOG4105C2C drug resistance transporter, Bcr CflA BLE401_RS14205 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BLE401_RS14210 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BLE401_RS14215 ENOG4105CFU surface antigen BLE401_RS14225 ENOG4107QKA exodeoxyribonuclease V beta BLE401_RS14230 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BLE401_RS14235 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BLE401_RS14245 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BLE401_RS14250 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BLE401_RS14285 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BLE401_RS14290 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BLE401_RS14340 ENOG4105EHI Phosphonate ABC transporter, periplasmic BLE401_RS14345 ENOG4105BZU Histidine kinase BLE401_RS14355 ENOG4108JU6 CBS domain protein BLE401_RS14360 ENOG4105CIH Imidazole acetol-phosphate transaminase BLE401_RS14365 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BLE401_RS14370 ENOG4105CW7 secretion protein, HlyD family BLE401_RS14385 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BLE401_RS14390 ENOG4108JPZ Monovalent cation H antiporter subunit D BLE401_RS14410 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BLE401_RS14425 ENOG4105CJ3 phosphate transporter BLE401_RS14465 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) BLE401_RS14470 ENOG4105WJX transcriptional regulator MERR family BLE401_RS14475 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BLE401_RS14480 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BLE401_RS14490 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BLE401_RS14495 ENOG4105CFV Tetratricopeptide repeat protein BLE401_RS14500 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BLE401_RS14505 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BLE401_RS14510 ENOG4105CAT Cytidine monophosphate kinase BLE401_RS14515 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BLE401_RS14525 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BLE401_RS14530 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BLE401_RS14535 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BLE401_RS14540 ENOG4105HBR Rna-binding protein BLE401_RS14560 ENOG4105CJW magnesium transporter BLE401_RS14585 ENOG4107QZM n-acetylglutamate synthase BLE401_RS14615 ENOG41072GX Peptidase M22 Glycoprotease BLE401_RS14650 ENOG4108IAJ Nad-dependent epimerase dehydratase BLE401_RS14660 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BLE401_RS14665 ENOG4108IAJ Nad-dependent epimerase dehydratase BLE401_RS14670 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BLE401_RS14685 ENOG4105FEA Spore maturation protein BLE401_RS14700 ENOG4105CPK Glycosyl transferase (Group 1 BLE401_RS14710 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BLE401_RS14725 ENOG4105NI8 Cytosine-specific methyltransferase BLE401_RS14775 ENOG4108176 endoribonuclease L-psp BLE401_RS14795 ENOG4105D5P Methylmalonyl-coA mutase BLE401_RS14805 ENOG4105D6Z AFG1 family ATPase BLE401_RS14810 ENOG4105BZU Histidine kinase BLE401_RS14815 ENOG4106RE7 Cytochrome BLE401_RS14830 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BLE401_RS14840 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BLE401_RS14850 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BLE401_RS14860 ENOG4107TF3 peptidylprolyl cis-trans isomerase BLE401_RS14870 ENOG4105K9H YciI-like protein BLE401_RS14880 ENOG4105KWW Biogenesis protein BLE401_RS14885 ENOG4107QX9 Thiol disulfide interChange protein BLE401_RS14890 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BLE401_RS14895 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BLE401_RS14900 ENOG4105E0C molybdate abc transporter BLE401_RS14915 ENOG4105CRQ synthase (Component I) BLE401_RS14945 ENOG4105C7K acetolactate synthase BLE401_RS14950 ENOG4108ZP8 Acetolactate synthase small subunit BLE401_RS14955 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BLE401_RS14960 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BLE401_RS14975 ENOG4108DY6 Extracellular solute-binding protein family 3 BLE401_RS14980 ENOG4105WJN methanol dehydrogenase-like protein, cytochrome cL (XoxG) BLE401_RS14985 ENOG4105DZG Dehydrogenase BLE401_RS14990 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BLE401_RS15050 ENOG4105D1F ATP-binding protein BLE401_RS15060 ENOG4108UHJ MAF-like protein BLE401_RS15065 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BLE401_RS15070 ENOG4105VGS 50s ribosomal protein l32 BLE401_RS15075 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BLE401_RS15080 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BLE401_RS15085 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BLE401_RS15090 ENOG4105CHR reductase BLE401_RS15095 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BLE401_RS15100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BLE401_RS15110 ENOG4105HHA aminodeoxychorismate lyase BLE401_RS15120 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BLE401_RS15125 ENOG4108RAC Rubrerythrin BLE401_RS15135 ENOG41075W9 High frequency lysogenization protein HflD homolog BLE401_RS15155 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BLE401_RS15160 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BLE401_RS15210 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) BLE401_RS15225 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BLE401_RS15255 ENOG4105MUA Resistance protein BLE401_RS15260 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BLE401_RS15265 ENOG4105CE9 30S ribosomal protein S2 BLE401_RS15270 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BLE401_RS15275 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BLE401_RS15280 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BLE401_RS15285 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BLE401_RS15290 ENOG4105KNE Phosphatidate cytidylyltransferase BLE401_RS15295 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BLE401_RS15300 ENOG4105DZP Membrane-associated zinc metalloprotease BLE401_RS15305 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BLE401_RS15315 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BLE401_RS15320 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BLE401_RS15325 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BLE401_RS15330 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BLE401_RS15335 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A BLE401_RS15340 ENOG4105C7H Helicase, RecD TraA family BLE401_RS15350 ENOG4105CNF WD-40 repeat protein BLE401_RS15360 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) BLE401_RS15365 ENOG4105BZU Histidine kinase BLE401_RS15415 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BLE401_RS15425 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BLE401_RS15450 ENOG41080RH Thioredoxin BLE401_RS15455 ENOG4108WWZ General secretion pathway protein J BLE401_RS15465 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) BLE401_RS15470 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BLE401_RS15485 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BLE401_RS15490 ENOG4105S10 periplasmic binding protein BLE401_RS15495 ENOG4105EHG Permease protein BLE401_RS15500 ENOG4105E0A ABC, transporter BLE401_RS15505 ENOG4105HB4 Pathways of utilization of iron bound to transferrin, lactoferrin and hemoglobin but not to haemin or citrate where dependent on the TonB system BLE401_RS15530 ENOG4105BZU Histidine kinase BLE401_RS15545 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BLE401_RS15555 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BLE401_RS15565 ENOG4107TH8 cina domain protein BLE401_RS15570 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BLE401_RS15575 ENOG4105Y3E Modulates RecA activity (By similarity) BLE401_RS15585 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BLE401_RS15615 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BLE401_RS15625 ENOG4105EZ7 amino acid ABC transporter BLE401_RS15630 ENOG4105DRP amino acid AbC transporter BLE401_RS15635 ENOG4105C45 hydrogenase expression formation protein (HypE) BLE401_RS15640 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BLE401_RS15645 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BLE401_RS15660 ENOG4105DH7 May be involved in recombination (By similarity) BLE401_RS15665 ENOG4105D7N magnesium and cobalt transport protein CorA BLE401_RS15690 ENOG4105EZE Cupin 4 family protein BLE401_RS15700 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BLE401_RS15705 ENOG4105CSM endonuclease III BLE401_RS15710 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BLE401_RS15715 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BLE401_RS15720 ENOG4105VTS DnaJ-like, subfamily C BLE401_RS15740 ENOG4108Z4V iron-sulfur cluster assembly BLE401_RS15745 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) BLE401_RS15760 ENOG4108ZIT Ferredoxin, 2FE-2S BLE401_RS15775 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BLE401_RS15785 ENOG4105CP2 von willebrand factor, type a BLE401_RS15790 ENOG4105ESV Glycosyl transferase, family 4 BLE401_RS15795 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) BLE401_RS15815 ENOG4105EHG Permease protein BLE401_RS15820 ENOG4105E2X shikimate dehydrogenase BLE401_RS15830 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BLE401_RS15860 ENOG41066HZ AIG2-like family BLE401_RS15865 ENOG4105F8J Adenylate Guanylate cyclase BLE401_RS15935 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BLE401_RS15950 ENOG4105D6E homoserine dehydrogenase BLE401_RS15975 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BLE401_RS15980 ENOG4105DSJ YicC domain protein BLE401_RS15985 ENOG4105CJ2 (LipO)protein BLE401_RS16005 ENOG4105RD5 BLE401_RS16015 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BLE401_RS16025 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BLE401_RS16050 ENOG4105XJC Two component transcriptional regulator (Winged helix family BLE401_RS16055 ENOG4105DHQ Histidine kinase BLE401_RS16060 ENOG4105DVF Cytosine-specific methyltransferase BLE401_RS16075 ENOG4105C3M thioredoxin reductase BLE401_RS16080 ENOG4105CNU cell division protein FtsK BLE401_RS16170 ENOG4105BZU Histidine kinase BLE401_RS16175 ENOG4105BZU Histidine kinase BLE401_RS16185 ENOG4107QKW extracellular solute-binding protein family 1 BLE401_RS16200 ENOG4105CKD glutathione-regulated potassium-efflux system protein BLE401_RS16225 ENOG4105EIE fructose-bisphosphate aldolase BLE401_RS16230 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BLE401_RS16240 ENOG4105BZU Histidine kinase BLE401_RS16245 ENOG4105VEQ Cold shock protein BLE401_RS16250 ENOG4105VEQ Cold shock protein BLE401_RS16255 ENOG4105VEQ Cold shock protein BLE401_RS16260 ENOG4105VEQ Cold shock protein BLE401_RS16265 ENOG4105VEQ Cold shock protein BLE401_RS16270 ENOG4105VEQ Cold shock protein BLE401_RS16275 ENOG4105VEQ Cold shock protein BLE401_RS16280 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BLE401_RS16285 ENOG4105W8H transhydrogenase (subunit alpha BLE401_RS16290 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BLE401_RS16300 ENOG4105E6M Sulphatase-modifying factor protein BLE401_RS16305 ENOG4107QYX exodeoxyribonuclease v alpha BLE401_RS16335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BLE401_RS16355 ENOG4105WN5 stage II sporulation protein BLE401_RS16375 ENOG4105CMV Succinyl-CoA synthetase subunit beta BLE401_RS16380 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BLE401_RS16385 ENOG4108YZA Nitrogen regulatory protein pii BLE401_RS16390 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BLE401_RS16435 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB BLE401_RS16445 ENOG4105P1D 4fe-4s ferredoxin, iron-sulfur binding BLE401_RS16450 ENOG4105ND9 Nitrogenase-associated protein BLE401_RS16455 ENOG4105CNW domain protein BLE401_RS16460 ENOG4105KXW Ferredoxin BLE401_RS16465 ENOG4105KXW Ferredoxin BLE401_RS16470 ENOG4105U82 Ferredoxin BLE401_RS16475 ENOG4105PS4 nifq family BLE401_RS16495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BLE401_RS16515 ENOG4108JPZ Monovalent cation H antiporter subunit D BLE401_RS16520 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BLE401_RS16530 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BLE401_RS16535 ENOG4105CHV Transcription elongation factor NusA BLE401_RS16540 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BLE401_RS16545 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BLE401_RS16550 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BLE401_RS16555 ENOG4107QHF type ii secretion system protein e BLE401_RS16565 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BLE401_RS16570 ENOG4105BZU Histidine kinase BLE401_RS16585 ENOG4105DJH phosphate BLE401_RS16600 ENOG4105D9P serine threonine protein kinase BLE401_RS16610 ENOG4105M00 molybdopterin converting factor, subunit 1 BLE401_RS16615 ENOG4108ZAF Molybdopterin BLE401_RS16620 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BLE401_RS16625 ENOG410832A alpha/beta hydrolase fold BLE401_RS16650 ENOG4105T95 Thiol disulfide interChange protein BLE401_RS16655 ENOG4108VPT UPF0234 protein BLE401_RS16660 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BLE401_RS16665 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BLE401_RS16670 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BLE401_RS16685 ENOG4108UGV hypoxanthine phosphoribosyltransferase BLE401_RS16690 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) BLE401_RS16700 ENOG41062WK cellular response to acidity BLE401_RS16705 ENOG4105BZU Histidine kinase BLE401_RS16715 ENOG4107QHF type ii secretion system protein e BLE401_RS16720 ENOG4107QX3 carboxylase BLE401_RS16735 ENOG4107R11 Transcriptional regulator BLE401_RS16740 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BLE401_RS16745 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BLE401_RS16750 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BLE401_RS16755 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BLE401_RS16760 ENOG4105D0M Protease HtpX homolog BLE401_RS16815 ENOG4108YZ9 Urea amidohydrolase subunit gamma BLE401_RS16830 ENOG4109015 Biopolymer transport protein exbD tolR BLE401_RS16835 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BLE401_RS16840 ENOG4105W49 UPF0434 protein BLE401_RS16845 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase BLE401_RS16880 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component BLE401_RS16885 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BLE401_RS16890 ENOG4105C7Z Conserved Protein BLE401_RS16895 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) BLE401_RS16910 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BLE401_RS16915 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BLE401_RS16920 ENOG4105D0M Protease HtpX homolog BLE401_RS16935 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BLE401_RS16955 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BLE401_RS16960 ENOG4105D8X mechanosensitive ion channel BLE401_RS16970 ENOG4105IBP Cyclic peptide transporter BLE401_RS16985 ENOG4105CNI cell division protein FtsW BLE401_RS17025 ENOG4105C26 Dehydrogenase BLE401_RS17035 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BLE401_RS17040 ENOG41090R7 Ferric uptake BLE401_RS17065 ENOG4105II7 pyrroline-5-carboxylate reductase BLE401_RS17070 ENOG4108VIA integral membrane protein BLE401_RS17075 ENOG4105VZ9 UPF0235 protein BLE401_RS17100 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BLE401_RS17105 ENOG4105C9A Phoh family BLE401_RS17115 ENOG4108JU5 Magnesium and cobalt efflux protein BLE401_RS17135 ENOG4105P8F nudix hydrolase BLE401_RS17150 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BLE401_RS17160 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BLE401_RS17170 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BLE401_RS17190 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BLE401_RS17200 ENOG4108W2Y isochorismatase BLE401_RS17215 ENOG4107835 probably involved in intracellular septation (By similarity) BLE401_RS17220 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BLE401_RS17230 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BLE401_RS17235 ENOG4105YYT phage shock protein B BLE401_RS17245 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BLE401_RS17250 ENOG4108JEH abc transporter atp-binding protein BLE401_RS17280 ENOG4105D9P serine threonine protein kinase BLE401_RS17285 ENOG4105C03 ribonuclease BLE401_RS17290 ENOG4105C0H protease BLE401_RS17300 ENOG4107QN2 dihydrolipoyl dehydrogenase BLE401_RS17305 ENOG4105CD8 aminopeptidase N BLE401_RS17325 ENOG4105BZU Histidine kinase BLE401_RS17340 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BLE401_RS17355 ENOG4105C8T Leucyl-tRNA synthetase BLE401_RS17370 ENOG4107SC1 transglycosylase BLE401_RS17385 ENOG4108UJU UPF0301 protein BLE401_RS17390 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BLE401_RS17395 ENOG4105CXT aspartate transcarbamylase BLE401_RS17400 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BLE401_RS17405 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BLE401_RS17410 ENOG4105D49 3-dehydroquinate synthase BLE401_RS17415 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BLE401_RS17420 ENOG4105BZU Histidine kinase BLE401_RS17465 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit BLE401_RS17480 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BLE401_RS17525 ENOG4105CDH Citrulline--aspartate ligase BLE401_RS17555 ENOG4105DU6 RNA polymerase BLE401_RS17570 ENOG4105BZU Histidine kinase BLE401_RS17575 ENOG4105D44 asparaginase BLE401_RS17580 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BLE401_RS17595 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BLE401_RS17600 ENOG4105VQ7 Rod shape-determining protein MreD BLE401_RS17605 ENOG4106032 Glutathionylspermidine synthase BLE401_RS17630 ENOG4105FGE Short-chain dehydrogenase reductase Sdr BLE401_RS17650 ENOG4105C6T cysteine synthase BLE401_RS17655 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BLE401_RS17660 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BLE401_RS17675 ENOG4108ZF3 Phosphatase BLE401_RS17685 ENOG4105DSP amino acid AbC transporter BLE401_RS17695 ENOG4108Z03 MAF-like protein BLE401_RS17700 ENOG4105CHM Aminotransferase BLE401_RS17715 ENOG4105UYK outer membrane protein a BLE401_RS17725 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BLE401_RS17730 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BLE401_RS17745 ENOG4108RPX mosc domain containing protein BLE401_RS17750 ENOG4105DK0 Indole-3-glycerol phosphate synthase BLE401_RS17785 ENOG4105BZU Histidine kinase BLE401_RS17790 ENOG4108ZCD Transcriptional coactivator pterin dehydratase BLE401_RS17800 ENOG4105F8J Adenylate Guanylate cyclase BLE401_RS17810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BLE401_RS17825 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BLE401_RS17840 ENOG4105C28 cystathionine BLE401_RS17875 ENOG4107QP3 malate synthase g BLE401_RS17895 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) BLE401_RS17900 ENOG4105DSF transport protein BLE401_RS17910 ENOG4105D05 Receptor BLE401_RS17915 ENOG4105CJP fad dependent oxidoreductase BLE401_RS17925 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BLE401_RS17930 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BLE401_RS17945 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase BLE401_RS17950 ENOG4105C5F glutamine synthetase BLE401_RS17960 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) BLE401_RS17970 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BLE401_RS17990 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system BLE401_RS18010 ENOG4108I0Z Aconitate hydratase BLE401_RS18015 ENOG4105C7F AcnD-accessory protein PrpF BLE401_RS18030 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A BLE401_RS18055 ENOG4105DXD 2-methylcitrate dehydratase BLE401_RS18060 ENOG4105BZN citrate synthase BLE401_RS18065 ENOG4105CR4 methylisocitrate lyase BLE401_RS18070 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BLE401_RS18085 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BLE401_RS18090 ENOG4105BZU Histidine kinase BLE401_RS18095 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BLE401_RS18100 ENOG4105F38 ABC transporter, permease BLE401_RS18105 ENOG4105D38 putrescine abc transporter BLE401_RS18140 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BLE401_RS18155 ENOG4105BZS acriflavin resistance protein BLE401_RS18165 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)