locus-tag	class	description
BLE401_RS00115	COG2356	endonuclease I
BLE401_RS00120	COG4974	Belongs to the 'phage' integrase family
BLE401_RS00260	COG3034	peptidoglycan biosynthetic process
BLE401_RS00265	COG0315	cyclic pyranopterin monophosphate synthase activity
BLE401_RS00275	COG0746	molybdenum cofactor guanylyltransferase activity
BLE401_RS00295	COG1196	nuclear chromosome segregation
BLE401_RS00305	COG0196	riboflavin kinase activity
BLE401_RS00310	COG0728	peptidoglycan biosynthetic process
BLE401_RS00315	COG0316	Belongs to the HesB IscA family
BLE401_RS00340	COG4251	negative regulation of phosphorylation
BLE401_RS00340	COG5001	Diguanylate cyclase
BLE401_RS00340	COG2203	Gaf domain
BLE401_RS00340	COG3706	GGDEF domain
BLE401_RS00350	COG0519	Catalyzes the synthesis of GMP from XMP
BLE401_RS00350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BLE401_RS00385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BLE401_RS00395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BLE401_RS00400	COG1181	Belongs to the D-alanine--D-alanine ligase family
BLE401_RS00405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BLE401_RS00420	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BLE401_RS00430	COG0653	protein targeting
BLE401_RS00435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BLE401_RS00455	COG1487	ribonuclease activity
BLE401_RS00475	COG0129	dihydroxy-acid dehydratase activity
BLE401_RS00510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BLE401_RS00515	COG1850	ribulose-bisphosphate carboxylase activity
BLE401_RS00520	COG4451	ribulose bisphosphate carboxylase, small
BLE401_RS00525	COG0741	lytic transglycosylase activity
BLE401_RS00525	COG1388	LysM domain
BLE401_RS00535	COG2847	Copper chaperone PCu(A)C
BLE401_RS00550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BLE401_RS00565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BLE401_RS00585	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
BLE401_RS00590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BLE401_RS00625	COG1690	Belongs to the RtcB family
BLE401_RS00640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BLE401_RS00645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BLE401_RS00705	COG0004	ammonium transporteR
BLE401_RS00725	COG3128	pkhd-type hydroxylase
BLE401_RS00730	COG4774	siderophore transport
BLE401_RS00740	COG1923	regulation of RNA biosynthetic process
BLE401_RS00750	COG3885	ferrous iron binding
BLE401_RS00750	COG2078	PFAM AMMECR1 domain protein
BLE401_RS00755	COG1355	regulation of microtubule-based process
BLE401_RS00785	COG2878	Part of a membrane complex involved in electron transport
BLE401_RS00790	COG4656	Part of a membrane complex involved in electron transport
BLE401_RS00805	COG4658	electron transport chain
BLE401_RS00825	COG2319	Wd-40 repeat
BLE401_RS00825	COG4249	Peptidase C14 caspase catalytic subunit p20
BLE401_RS00850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BLE401_RS00885	COG0508	dehydrogenase complex catalyzes the overall conversion of
BLE401_RS00900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BLE401_RS00905	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BLE401_RS00910	COG0594	ribonuclease P activity
BLE401_RS00915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BLE401_RS00920	COG0706	membrane insertase activity
BLE401_RS00935	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS00935	COG1216	Glycosyl transferase, family 2
BLE401_RS00940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BLE401_RS00945	COG0798	PFAM Bile acid sodium symporter
BLE401_RS00950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BLE401_RS00965	COG0521	Mo-molybdopterin cofactor biosynthetic process
BLE401_RS00990	COG0736	holo-[acyl-carrier-protein] synthase activity
BLE401_RS00995	COG0702	epimerase
BLE401_RS01005	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
BLE401_RS01015	COG1368	sulfuric ester hydrolase activity
BLE401_RS01025	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BLE401_RS01040	COG0745	RESPONSE REGULATOR receiver
BLE401_RS01055	COG2989	Protein conserved in bacteria
BLE401_RS01060	COG3108	Peptidase M15
BLE401_RS01110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BLE401_RS01115	COG2205	protein histidine kinase activity
BLE401_RS01115	COG3437	response regulator, receiver
BLE401_RS01115	COG3850	Histidine kinase
BLE401_RS01115	COG4999	Histidine kinase
BLE401_RS01140	COG0730	response to heat
BLE401_RS01145	COG0802	atpase or kinase
BLE401_RS01180	COG1136	(ABC) transporter
BLE401_RS01185	COG0577	efflux transmembrane transporter activity
BLE401_RS01185	COG1136	(ABC) transporter
BLE401_RS01190	COG0210	DNA helicase
BLE401_RS01245	COG0445	tRNA wobble uridine modification
BLE401_RS01300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BLE401_RS01305	COG4569	acetaldehyde dehydrogenase (acetylating) activity
BLE401_RS01380	COG2205	protein histidine kinase activity
BLE401_RS01380	COG3437	response regulator, receiver
BLE401_RS01380	COG4999	Histidine kinase
BLE401_RS01380	COG3850	Histidine kinase
BLE401_RS01410	COG2949	membrane
BLE401_RS01415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BLE401_RS01420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLE401_RS01460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BLE401_RS01515	COG1196	nuclear chromosome segregation
BLE401_RS01515	COG3264	Mechanosensitive ion channel
BLE401_RS01530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BLE401_RS01535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BLE401_RS01550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BLE401_RS01555	COG0546	phosphoglycolate phosphatase activity
BLE401_RS01570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BLE401_RS01575	COG0259	pyridoxamine-phosphate oxidase activity
BLE401_RS01595	COG2205	protein histidine kinase activity
BLE401_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS01605	COG2226	methyltransferase
BLE401_RS01625	COG0840	transmembrane signaling receptor activity
BLE401_RS01640	COG0842	Transport permease protein
BLE401_RS01645	COG1131	(ABC) transporter
BLE401_RS01650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS01665	COG0784	Response regulator, receiver
BLE401_RS01665	COG2198	Histidine kinase
BLE401_RS01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS01665	COG2205	protein histidine kinase activity
BLE401_RS01675	COG4172	Belongs to the ABC transporter superfamily
BLE401_RS01680	COG3243	poly(R)-hydroxyalkanoic acid synthase
BLE401_RS01690	COG0784	Response regulator, receiver
BLE401_RS01690	COG2198	Histidine kinase
BLE401_RS01690	COG5002	protein histidine kinase activity
BLE401_RS01695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BLE401_RS01705	COG0784	Response regulator, receiver
BLE401_RS01705	COG2205	protein histidine kinase activity
BLE401_RS01725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BLE401_RS01730	COG0571	ribonuclease III activity
BLE401_RS01745	COG0481	GTPase activity
BLE401_RS01755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLE401_RS01770	COG0189	ligase activity
BLE401_RS01775	COG1773	rubredoxin
BLE401_RS01805	COG0741	lytic transglycosylase activity
BLE401_RS01820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BLE401_RS01825	COG1132	(ABC) transporter
BLE401_RS01840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BLE401_RS01845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BLE401_RS01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BLE401_RS01880	COG2239	Acts as a magnesium transporter
BLE401_RS01905	COG0747	negative chemotaxis
BLE401_RS01920	COG2192	nodulation
BLE401_RS01935	COG0488	(ABC) transporter
BLE401_RS01940	COG5002	protein histidine kinase activity
BLE401_RS01940	COG2205	protein histidine kinase activity
BLE401_RS01940	COG0784	Response regulator, receiver
BLE401_RS01945	COG3852	Histidine kinase
BLE401_RS01965	COG2205	protein histidine kinase activity
BLE401_RS01965	COG2198	Histidine kinase
BLE401_RS01965	COG0784	Response regulator, receiver
BLE401_RS01970	COG3391	amine dehydrogenase activity
BLE401_RS01980	COG2884	Cell division ATP-binding protein ftsE
BLE401_RS01985	COG0142	geranyltranstransferase activity
BLE401_RS01990	COG0529	Catalyzes the synthesis of activated sulfate
BLE401_RS02005	COG2096	Adenosyltransferase
BLE401_RS02015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLE401_RS02020	COG2119	membrane
BLE401_RS02025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BLE401_RS02035	COG0123	including yeast histone deacetylase and acetoin utilization protein
BLE401_RS02045	COG3850	Histidine kinase
BLE401_RS02075	COG1126	abc transporter atp-binding protein
BLE401_RS02095	COG0310	cobalt ion transport
BLE401_RS02100	COG0310	cobalt ion transport
BLE401_RS02110	COG5002	protein histidine kinase activity
BLE401_RS02110	COG5001	Diguanylate cyclase
BLE401_RS02125	COG0436	Aminotransferase
BLE401_RS02130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BLE401_RS02140	COG3311	Transcriptional regulator
BLE401_RS02145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BLE401_RS02155	COG2205	protein histidine kinase activity
BLE401_RS02155	COG0784	Response regulator, receiver
BLE401_RS02180	COG0475	glutathione-regulated potassium exporter activity
BLE401_RS02215	COG3409	Peptidoglycan-binding domain 1 protein
BLE401_RS02215	COG3267	Type II secretory pathway component ExeA
BLE401_RS02220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BLE401_RS02230	COG0742	ribosomal rna small subunit methyltransferase
BLE401_RS02250	COG2885	chlorophyll binding
BLE401_RS02255	COG0159	tryptophan synthase activity
BLE401_RS02260	COG0133	tryptophan synthase activity
BLE401_RS02265	COG1960	acyl-CoA dehydrogenase activity
BLE401_RS02270	COG1960	acyl-CoA dehydrogenase activity
BLE401_RS02300	COG2204	response regulator
BLE401_RS02305	COG2363	Small membrane protein
BLE401_RS02310	COG0142	geranyltranstransferase activity
BLE401_RS02320	COG0582	viral genome integration into host DNA
BLE401_RS02355	COG1598	PFAM Uncharacterised protein family UPF0150
BLE401_RS02420	COG1598	PFAM Uncharacterised protein family UPF0150
BLE401_RS02460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BLE401_RS02475	COG0500	methyltransferase
BLE401_RS02480	COG2967	ApaG domain
BLE401_RS02485	COG2226	methyltransferase
BLE401_RS02490	COG0446	pyridine nucleotide-disulphide oxidoreductase
BLE401_RS02500	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS02510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BLE401_RS02520	COG0604	alcohol dehydrogenase
BLE401_RS02525	COG3240	lipase activity
BLE401_RS02535	COG2205	protein histidine kinase activity
BLE401_RS02535	COG0784	Response regulator, receiver
BLE401_RS02545	COG2906	2 iron, 2 sulfur cluster binding
BLE401_RS02565	COG0071	Belongs to the small heat shock protein (HSP20) family
BLE401_RS02575	COG1570	exodeoxyribonuclease VII activity
BLE401_RS02580	COG1051	belongs to the nudix hydrolase family
BLE401_RS02595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BLE401_RS02600	COG4942	peptidase
BLE401_RS02620	COG0484	heat shock protein binding
BLE401_RS02625	COG0402	S-adenosylhomocysteine deaminase activity
BLE401_RS02650	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BLE401_RS02655	COG0527	aspartate kinase activity
BLE401_RS02660	COG0784	Response regulator, receiver
BLE401_RS02660	COG2205	protein histidine kinase activity
BLE401_RS02680	COG2030	dehydratase
BLE401_RS02685	COG0165	Argininosuccinate lyase
BLE401_RS02695	COG0505	Belongs to the CarA family
BLE401_RS02700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BLE401_RS02705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BLE401_RS02720	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BLE401_RS02725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BLE401_RS02730	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BLE401_RS02735	COG2373	Large extracellular alpha-helical protein
BLE401_RS02740	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BLE401_RS02750	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BLE401_RS02765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BLE401_RS02790	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BLE401_RS02795	COG0149	triose-phosphate isomerase activity
BLE401_RS02800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BLE401_RS02805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BLE401_RS02810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BLE401_RS02830	COG3597	protein domain associated with
BLE401_RS02850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLE401_RS02905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BLE401_RS02910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BLE401_RS02930	COG0069	glutamate synthase activity
BLE401_RS02940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BLE401_RS02955	COG0303	'Molybdopterin
BLE401_RS02970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS03005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS03010	COG0840	transmembrane signaling receptor activity
BLE401_RS03030	COG5002	protein histidine kinase activity
BLE401_RS03030	COG0784	Response regulator, receiver
BLE401_RS03030	COG2198	Histidine kinase
BLE401_RS03040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BLE401_RS03055	COG0584	glycerophosphoryl diester phosphodiesterase
BLE401_RS03070	COG0840	transmembrane signaling receptor activity
BLE401_RS03075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BLE401_RS03080	COG3954	Phosphoribulokinase
BLE401_RS03090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLE401_RS03090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLE401_RS03095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BLE401_RS03115	COG0837	glucose binding
BLE401_RS03135	COG0792	nuclease activity
BLE401_RS03145	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BLE401_RS03150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BLE401_RS03155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BLE401_RS03170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BLE401_RS03175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BLE401_RS03210	COG0741	lytic transglycosylase activity
BLE401_RS03220	COG5002	protein histidine kinase activity
BLE401_RS03220	COG2205	protein histidine kinase activity
BLE401_RS03220	COG0784	Response regulator, receiver
BLE401_RS03240	COG2885	chlorophyll binding
BLE401_RS03260	COG1166	arginine decarboxylase activity
BLE401_RS03285	COG0322	excinuclease ABC activity
BLE401_RS03300	COG0508	dehydrogenase complex catalyzes the overall conversion of
BLE401_RS03315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BLE401_RS03325	COG0359	binds to the 23S rRNA
BLE401_RS03330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BLE401_RS03335	COG0360	Binds together with S18 to 16S ribosomal RNA
BLE401_RS03340	COG1765	OsmC-like protein
BLE401_RS03345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BLE401_RS03350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BLE401_RS03360	COG0183	Belongs to the thiolase family
BLE401_RS03365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BLE401_RS03415	COG3243	poly(R)-hydroxyalkanoic acid synthase
BLE401_RS03435	COG1858	cytochrome C peroxidase
BLE401_RS03470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BLE401_RS03475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BLE401_RS03480	COG4133	protoheme IX ABC transporter activity
BLE401_RS03500	COG1129	ABC transporter
BLE401_RS03530	COG0321	lipoyl(octanoyl) transferase activity
BLE401_RS03535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BLE401_RS03560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS03560	COG2205	protein histidine kinase activity
BLE401_RS03565	COG0375	protein maturation
BLE401_RS03570	COG0298	carbon dioxide binding
BLE401_RS03580	COG0493	'glutamate synthase
BLE401_RS03585	COG0070	glutamate synthase
BLE401_RS03585	COG0069	glutamate synthase activity
BLE401_RS03585	COG0067	glutamate synthase
BLE401_RS03590	COG2918	glutathione biosynthetic process
BLE401_RS03610	COG0735	belongs to the Fur family
BLE401_RS03630	COG2914	Belongs to the UPF0125 (RnfH) family
BLE401_RS03645	COG4658	electron transport chain
BLE401_RS03650	COG4656	Part of a membrane complex involved in electron transport
BLE401_RS03655	COG2878	Part of a membrane complex involved in electron transport
BLE401_RS03660	COG4657	Part of a membrane complex involved in electron transport
BLE401_RS03670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BLE401_RS03675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BLE401_RS03680	COG4660	Part of a membrane complex involved in electron transport
BLE401_RS03700	COG1597	lipid kinase activity
BLE401_RS03715	COG2862	Uncharacterized protein family, UPF0114
BLE401_RS03725	COG1459	type II secretion system
BLE401_RS03740	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BLE401_RS03800	COG1758	RNA polymerase activity
BLE401_RS03805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLE401_RS03815	COG0006	proline dipeptidase activity
BLE401_RS03820	COG1022	Amp-dependent synthetase and ligase
BLE401_RS03835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BLE401_RS03840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BLE401_RS03860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BLE401_RS03865	COG0418	dihydroorotase activity
BLE401_RS03875	COG2203	Gaf domain
BLE401_RS03875	COG5001	Diguanylate cyclase
BLE401_RS03875	COG3706	GGDEF domain
BLE401_RS03875	COG4251	negative regulation of phosphorylation
BLE401_RS03885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BLE401_RS03890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS03900	COG0312	modulator of DNA gyrase
BLE401_RS03925	COG1469	GTP cyclohydrolase I activity
BLE401_RS03930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BLE401_RS03955	COG0745	RESPONSE REGULATOR receiver
BLE401_RS03960	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BLE401_RS03960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BLE401_RS03985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BLE401_RS04005	COG0330	HflC and HflK could
BLE401_RS04010	COG0037	tRNA processing
BLE401_RS04015	COG0560	Phosphoserine phosphatase
BLE401_RS04025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BLE401_RS04030	COG0737	Belongs to the 5'-nucleotidase family
BLE401_RS04050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS04055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BLE401_RS04065	COG1842	Phage shock protein A
BLE401_RS04095	COG1116	anion transmembrane transporter activity
BLE401_RS04115	COG5002	protein histidine kinase activity
BLE401_RS04115	COG2205	protein histidine kinase activity
BLE401_RS04115	COG0784	Response regulator, receiver
BLE401_RS04125	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BLE401_RS04135	COG0215	cysteine-tRNA ligase activity
BLE401_RS04145	COG0546	phosphoglycolate phosphatase activity
BLE401_RS04165	COG0784	Response regulator, receiver
BLE401_RS04165	COG2198	Histidine kinase
BLE401_RS04165	COG5002	protein histidine kinase activity
BLE401_RS04180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BLE401_RS04200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BLE401_RS04230	COG3218	ABC-type transport auxiliary lipoprotein component
BLE401_RS04265	COG3025	triphosphatase activity
BLE401_RS04275	COG0583	DNA-binding transcription factor activity
BLE401_RS04280	COG2770	Histidine kinase
BLE401_RS04280	COG2208	phosphoserine phosphatase activity
BLE401_RS04295	COG5002	protein histidine kinase activity
BLE401_RS04295	COG2176	DNA-directed DNA polymerase activity
BLE401_RS04300	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BLE401_RS04300	COG0662	Cupin 2, conserved barrel domain protein
BLE401_RS04305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BLE401_RS04320	COG3001	Fructosamine kinase
BLE401_RS04330	COG2205	protein histidine kinase activity
BLE401_RS04330	COG0784	Response regulator, receiver
BLE401_RS04340	COG2197	response regulator
BLE401_RS04370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BLE401_RS04380	COG3755	Protein conserved in bacteria
BLE401_RS04385	COG0860	N-Acetylmuramoyl-L-alanine amidase
BLE401_RS04440	COG0312	modulator of DNA gyrase
BLE401_RS04445	COG4797	methyltransferase
BLE401_RS04445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BLE401_RS04465	COG1194	a g-specific adenine glycosylase
BLE401_RS04470	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BLE401_RS04485	COG0357	Ribosomal RNA small subunit methyltransferase G
BLE401_RS04490	COG2921	Belongs to the UPF0250 family
BLE401_RS04495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BLE401_RS04505	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BLE401_RS04510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BLE401_RS04515	COG2205	protein histidine kinase activity
BLE401_RS04515	COG3437	response regulator, receiver
BLE401_RS04515	COG3850	Histidine kinase
BLE401_RS04515	COG4999	Histidine kinase
BLE401_RS04520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLE401_RS04530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BLE401_RS04535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BLE401_RS04535	COG3320	Male sterility
BLE401_RS04550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BLE401_RS04555	COG3604	Transcriptional regulator
BLE401_RS04560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BLE401_RS04565	COG0730	response to heat
BLE401_RS04575	COG3409	Peptidoglycan-binding domain 1 protein
BLE401_RS04575	COG3267	Type II secretory pathway component ExeA
BLE401_RS04600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BLE401_RS04605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BLE401_RS04605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BLE401_RS04635	COG3243	poly(R)-hydroxyalkanoic acid synthase
BLE401_RS04640	COG2202	Pas domain
BLE401_RS04640	COG2205	protein histidine kinase activity
BLE401_RS04655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BLE401_RS04670	COG2914	Belongs to the UPF0125 (RnfH) family
BLE401_RS04690	COG0386	Belongs to the glutathione peroxidase family
BLE401_RS04695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BLE401_RS04705	COG5265	(ABC) transporter
BLE401_RS04720	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BLE401_RS04765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BLE401_RS04785	COG1773	rubredoxin
BLE401_RS04790	COG2770	Histidine kinase
BLE401_RS04790	COG2208	phosphoserine phosphatase activity
BLE401_RS04800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BLE401_RS04805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BLE401_RS04810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLE401_RS04815	COG0217	transcriptional regulatory protein
BLE401_RS04820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BLE401_RS04835	COG1215	transferase activity, transferring glycosyl groups
BLE401_RS04845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BLE401_RS04845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BLE401_RS04850	COG0285	dihydrofolate synthase activity
BLE401_RS04855	COG0148	phosphopyruvate hydratase activity
BLE401_RS04860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BLE401_RS04865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BLE401_RS04875	COG1587	Uroporphyrinogen-III synthase
BLE401_RS04885	COG1017	nitric oxide dioxygenase activity
BLE401_RS04885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BLE401_RS04895	COG0442	prolyl-tRNA aminoacylation
BLE401_RS04910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BLE401_RS04920	COG0745	RESPONSE REGULATOR receiver
BLE401_RS04925	COG2198	Histidine kinase
BLE401_RS04925	COG0643	Histidine kinase
BLE401_RS04930	COG0835	chemotaxis
BLE401_RS04975	COG2132	Multicopper oxidase
BLE401_RS04985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BLE401_RS04990	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BLE401_RS04995	COG4181	ATPase activity
BLE401_RS05015	COG0753	catalase activity
BLE401_RS05020	COG4174	ABC transporter (Permease)
BLE401_RS05030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BLE401_RS05035	COG0784	Response regulator, receiver
BLE401_RS05035	COG2205	protein histidine kinase activity
BLE401_RS05035	COG2198	Histidine kinase
BLE401_RS05040	COG1139	Iron-sulfur cluster binding protein
BLE401_RS05045	COG1556	Lactate utilization protein
BLE401_RS05050	COG0745	RESPONSE REGULATOR receiver
BLE401_RS05055	COG2176	DNA-directed DNA polymerase activity
BLE401_RS05055	COG5002	protein histidine kinase activity
BLE401_RS05065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BLE401_RS05085	COG0714	Associated with various cellular activities
BLE401_RS05100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BLE401_RS05105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BLE401_RS05130	COG5001	Diguanylate cyclase
BLE401_RS05130	COG5002	protein histidine kinase activity
BLE401_RS05160	COG2205	protein histidine kinase activity
BLE401_RS05160	COG3437	response regulator, receiver
BLE401_RS05160	COG3850	Histidine kinase
BLE401_RS05160	COG4999	Histidine kinase
BLE401_RS05165	COG2205	protein histidine kinase activity
BLE401_RS05165	COG3437	response regulator, receiver
BLE401_RS05165	COG3850	Histidine kinase
BLE401_RS05165	COG4999	Histidine kinase
BLE401_RS05185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BLE401_RS05200	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BLE401_RS05205	COG2050	protein possibly involved in aromatic compounds catabolism
BLE401_RS05210	COG2205	protein histidine kinase activity
BLE401_RS05210	COG3437	response regulator, receiver
BLE401_RS05210	COG3850	Histidine kinase
BLE401_RS05210	COG4999	Histidine kinase
BLE401_RS05215	COG3706	GGDEF domain
BLE401_RS05225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BLE401_RS05285	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BLE401_RS05290	COG0277	FAD linked oxidase domain protein
BLE401_RS05295	COG0247	lactate metabolic process
BLE401_RS05320	COG3008	intermembrane lipid transfer
BLE401_RS05325	COG2995	paraquat-inducible protein a
BLE401_RS05355	COG0420	3'-5' exonuclease activity
BLE401_RS05360	COG2205	protein histidine kinase activity
BLE401_RS05360	COG2198	Histidine kinase
BLE401_RS05360	COG0784	Response regulator, receiver
BLE401_RS05375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BLE401_RS05430	COG0784	Response regulator, receiver
BLE401_RS05430	COG2205	protein histidine kinase activity
BLE401_RS05435	COG1942	4-Oxalocrotonate Tautomerase
BLE401_RS05440	COG0464	growth
BLE401_RS05455	COG0697	spore germination
BLE401_RS05460	COG0463	Glycosyl transferase, family 2
BLE401_RS05465	COG0339	signal peptide processing
BLE401_RS05475	COG1131	(ABC) transporter
BLE401_RS05495	COG0187	DNA topoisomerase II activity
BLE401_RS05525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BLE401_RS05530	COG1053	succinate dehydrogenase
BLE401_RS05535	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BLE401_RS05540	COG2009	succinate dehydrogenase
BLE401_RS05555	COG2176	DNA-directed DNA polymerase activity
BLE401_RS05560	COG2943	transferase activity, transferring hexosyl groups
BLE401_RS05570	COG0494	nUDIX hydrolase
BLE401_RS05575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BLE401_RS05580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BLE401_RS05585	COG0519	Catalyzes the synthesis of GMP from XMP
BLE401_RS05595	COG3116	cell division
BLE401_RS05605	COG1643	Atp-dependent helicase
BLE401_RS05615	COG0864	Transcriptional regulator
BLE401_RS05620	COG0641	radical SAM
BLE401_RS05625	COG0784	Response regulator, receiver
BLE401_RS05625	COG5002	protein histidine kinase activity
BLE401_RS05630	COG0252	asparaginase activity
BLE401_RS05635	COG2217	Heavy metal translocating P-type atpase
BLE401_RS05665	COG1918	ferrous iron import across plasma membrane
BLE401_RS05685	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BLE401_RS05705	COG1472	Belongs to the glycosyl hydrolase 3 family
BLE401_RS05735	COG2192	nodulation
BLE401_RS05745	COG2192	nodulation
BLE401_RS05820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BLE401_RS05835	COG0793	Belongs to the peptidase S41A family
BLE401_RS05840	COG4942	peptidase
BLE401_RS05895	COG0546	phosphoglycolate phosphatase activity
BLE401_RS05895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BLE401_RS05900	COG0277	FAD linked oxidase domain protein
BLE401_RS05915	COG0151	Belongs to the GarS family
BLE401_RS05920	COG0138	bifunctional purine biosynthesis protein purh
BLE401_RS05975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BLE401_RS06000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BLE401_RS06015	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BLE401_RS06030	COG2010	Cytochrome c
BLE401_RS06045	COG3278	Belongs to the heme-copper respiratory oxidase family
BLE401_RS06055	COG2217	Heavy metal translocating P-type atpase
BLE401_RS06060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BLE401_RS06070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BLE401_RS06110	COG0523	cobalamin synthesis protein
BLE401_RS06150	COG2890	protein-(glutamine-N5) methyltransferase activity
BLE401_RS06160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BLE401_RS06165	COG0582	viral genome integration into host DNA
BLE401_RS06170	COG0101	tRNA pseudouridine synthase activity
BLE401_RS06180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BLE401_RS06185	COG0473	3-isopropylmalate dehydrogenase activity
BLE401_RS06195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BLE401_RS06210	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BLE401_RS06220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BLE401_RS06225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BLE401_RS06235	COG5002	protein histidine kinase activity
BLE401_RS06235	COG2198	Histidine kinase
BLE401_RS06235	COG0784	Response regulator, receiver
BLE401_RS06245	COG0641	radical SAM
BLE401_RS06255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BLE401_RS06260	COG1132	(ABC) transporter
BLE401_RS06265	COG1704	LemA family
BLE401_RS06270	COG0084	hydrolase, TatD family'
BLE401_RS06275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BLE401_RS06280	COG0784	Response regulator, receiver
BLE401_RS06280	COG2205	protein histidine kinase activity
BLE401_RS06285	COG5002	protein histidine kinase activity
BLE401_RS06285	COG0784	Response regulator, receiver
BLE401_RS06295	COG0270	DNA (cytosine-5-)-methyltransferase activity
BLE401_RS06305	COG0156	8-amino-7-oxononanoate synthase activity
BLE401_RS06310	COG2957	Belongs to the agmatine deiminase family
BLE401_RS06325	COG0277	FAD linked oxidase domain protein
BLE401_RS06335	COG0586	Pfam SNARE associated Golgi protein
BLE401_RS06350	COG0488	(ABC) transporter
BLE401_RS06360	COG3030	protein affecting phage T7 exclusion by the F plasmid
BLE401_RS06370	COG1012	belongs to the aldehyde dehydrogenase family
BLE401_RS06380	COG2205	protein histidine kinase activity
BLE401_RS06380	COG2202	Pas domain
BLE401_RS06385	COG0563	adenylate kinase activity
BLE401_RS06410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BLE401_RS06415	COG2255	four-way junction helicase activity
BLE401_RS06420	COG0824	Thioesterase
BLE401_RS06425	COG0811	peptide transport
BLE401_RS06440	COG0823	Involved in the tonB-independent uptake of proteins
BLE401_RS06445	COG2885	chlorophyll binding
BLE401_RS06455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BLE401_RS06465	COG3577	Aspartyl protease
BLE401_RS06475	COG0741	lytic transglycosylase activity
BLE401_RS06490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BLE401_RS06550	COG0805	protein transport
BLE401_RS06555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BLE401_RS06560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BLE401_RS06570	COG0140	phosphoribosyl-ATP diphosphatase activity
BLE401_RS06580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BLE401_RS06590	COG0107	imidazoleglycerol-phosphate synthase activity
BLE401_RS06595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BLE401_RS06600	COG0840	transmembrane signaling receptor activity
BLE401_RS06620	COG2833	Protein of unknown function (DUF455)
BLE401_RS06645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BLE401_RS06650	COG3047	cAMP biosynthetic process
BLE401_RS06655	COG2202	Pas domain
BLE401_RS06655	COG2205	protein histidine kinase activity
BLE401_RS06675	COG0667	Aldo Keto reductase
BLE401_RS06695	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BLE401_RS06700	COG2204	response regulator
BLE401_RS06710	COG0668	transmembrane transport
BLE401_RS06715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BLE401_RS06720	COG0697	spore germination
BLE401_RS06735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BLE401_RS06735	COG0574	Belongs to the PEP-utilizing enzyme family
BLE401_RS06765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BLE401_RS06770	COG0009	L-threonylcarbamoyladenylate synthase
BLE401_RS06775	COG0408	coproporphyrinogen oxidase activity
BLE401_RS06780	COG4656	Part of a membrane complex involved in electron transport
BLE401_RS06800	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BLE401_RS06810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BLE401_RS06815	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BLE401_RS06830	COG1192	Involved in chromosome partitioning
BLE401_RS06835	COG2204	response regulator
BLE401_RS06840	COG2199	diguanylate cyclase activity
BLE401_RS06840	COG2203	Gaf domain
BLE401_RS06860	COG4717	serine-type aminopeptidase activity
BLE401_RS06865	COG0288	reversible hydration of carbon dioxide
BLE401_RS06910	COG1752	Esterase of the alpha-beta hydrolase superfamily
BLE401_RS06915	COG1160	GTP binding
BLE401_RS06935	COG1960	acyl-CoA dehydrogenase activity
BLE401_RS06945	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BLE401_RS06950	COG0732	type I restriction modification DNA specificity domain
BLE401_RS06955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BLE401_RS06970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS06985	COG0697	spore germination
BLE401_RS06995	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS07010	COG4191	Histidine kinase
BLE401_RS07020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BLE401_RS07050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BLE401_RS07055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BLE401_RS07060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BLE401_RS07070	COG5000	phosphorelay sensor kinase activity
BLE401_RS07075	COG2204	response regulator
BLE401_RS07080	COG0569	domain protein
BLE401_RS07095	COG0840	transmembrane signaling receptor activity
BLE401_RS07125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BLE401_RS07130	COG0247	lactate metabolic process
BLE401_RS07140	COG1640	4-alpha-glucanotransferase
BLE401_RS07150	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BLE401_RS07155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BLE401_RS07160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BLE401_RS07165	COG0644	oxidoreductase
BLE401_RS07165	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BLE401_RS07180	COG0745	RESPONSE REGULATOR receiver
BLE401_RS07185	COG2205	protein histidine kinase activity
BLE401_RS07190	COG0352	thiamine-phosphate diphosphorylase activity
BLE401_RS07200	COG2022	thiamine diphosphate biosynthetic process
BLE401_RS07215	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS07240	COG0489	protein tyrosine kinase activity
BLE401_RS07240	COG3206	protein involved in exopolysaccharide biosynthesis
BLE401_RS07250	COG2358	TRAP transporter, solute receptor (TAXI family
BLE401_RS07265	COG2205	protein histidine kinase activity
BLE401_RS07265	COG0784	Response regulator, receiver
BLE401_RS07280	COG2208	phosphoserine phosphatase activity
BLE401_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS07315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BLE401_RS07325	COG2226	methyltransferase
BLE401_RS07335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BLE401_RS07345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BLE401_RS07355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BLE401_RS07365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BLE401_RS07370	COG0535	radical SAM domain protein
BLE401_RS07380	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BLE401_RS07405	COG1131	(ABC) transporter
BLE401_RS07410	COG0616	signal peptide processing
BLE401_RS07420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BLE401_RS07430	COG2264	protein methyltransferase activity
BLE401_RS07435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BLE401_RS07450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BLE401_RS07470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BLE401_RS07475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS07480	COG1611	Belongs to the LOG family
BLE401_RS07505	COG2920	part of a sulfur-relay system
BLE401_RS07510	COG2168	tRNA wobble position uridine thiolation
BLE401_RS07515	COG2923	Belongs to the DsrF TusC family
BLE401_RS07520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BLE401_RS07525	COG0484	heat shock protein binding
BLE401_RS07530	COG1215	transferase activity, transferring glycosyl groups
BLE401_RS07540	COG0756	dUTP diphosphatase activity
BLE401_RS07575	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BLE401_RS07590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BLE401_RS07610	COG1959	2 iron, 2 sulfur cluster binding
BLE401_RS07615	COG1104	cysteine desulfurase activity
BLE401_RS07620	COG1104	cysteine desulfurase activity
BLE401_RS07635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BLE401_RS07640	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BLE401_RS07650	COG0497	DNA recombination
BLE401_RS07655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BLE401_RS07660	COG0617	tRNA 3'-terminal CCA addition
BLE401_RS07700	COG0542	response to heat
BLE401_RS07705	COG1968	undecaprenyl-diphosphatase activity
BLE401_RS07715	COG3852	Histidine kinase
BLE401_RS07720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BLE401_RS07725	COG2911	Protein conserved in bacteria
BLE401_RS07740	COG4260	virion core protein, lumpy skin disease virus
BLE401_RS07750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BLE401_RS07755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BLE401_RS07760	COG0686	Belongs to the AlaDH PNT family
BLE401_RS07775	COG1610	YqeY-like protein
BLE401_RS07780	COG0358	DNA primase activity
BLE401_RS07795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BLE401_RS07800	COG1137	ATPase activity
BLE401_RS07805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BLE401_RS07820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BLE401_RS07830	COG2304	oxidoreductase activity
BLE401_RS07835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BLE401_RS07840	COG0784	Response regulator, receiver
BLE401_RS07840	COG5002	protein histidine kinase activity
BLE401_RS07840	COG2198	Histidine kinase
BLE401_RS07865	COG2198	Histidine kinase
BLE401_RS07865	COG2205	protein histidine kinase activity
BLE401_RS07865	COG0784	Response regulator, receiver
BLE401_RS07870	COG0012	GTP binding
BLE401_RS07875	COG1083	cytidylyl-transferase
BLE401_RS07885	COG2089	acid synthase
BLE401_RS07895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BLE401_RS07900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BLE401_RS07905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BLE401_RS07915	COG0297	glycogen (starch) synthase activity
BLE401_RS07920	COG0343	queuine tRNA-ribosyltransferase activity
BLE401_RS07925	COG2205	protein histidine kinase activity
BLE401_RS07925	COG2202	Pas domain
BLE401_RS07955	COG3038	cytochrome b561
BLE401_RS07975	COG2885	chlorophyll binding
BLE401_RS07980	COG0829	nickel cation binding
BLE401_RS08000	COG1660	Displays ATPase and GTPase activities
BLE401_RS08005	COG0126	phosphoglycerate kinase activity
BLE401_RS08010	COG2171	N-acyltransferase activity
BLE401_RS08015	COG0436	Aminotransferase
BLE401_RS08020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BLE401_RS08030	COG0745	RESPONSE REGULATOR receiver
BLE401_RS08035	COG2205	protein histidine kinase activity
BLE401_RS08040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BLE401_RS08045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BLE401_RS08050	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BLE401_RS08060	COG0180	Tryptophanyl-tRNA synthetase
BLE401_RS08095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BLE401_RS08095	COG1199	ATP-dependent helicase activity
BLE401_RS08100	COG0347	Belongs to the P(II) protein family
BLE401_RS08105	COG0004	ammonium transporteR
BLE401_RS08110	COG0004	ammonium transporteR
BLE401_RS08125	COG0837	glucose binding
BLE401_RS08145	COG0105	UTP biosynthetic process
BLE401_RS08150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BLE401_RS08160	COG1426	Protein conserved in bacteria
BLE401_RS08165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BLE401_RS08170	COG0124	histidyl-tRNA synthetase
BLE401_RS08175	COG2976	Protein conserved in bacteria
BLE401_RS08185	COG2205	protein histidine kinase activity
BLE401_RS08185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS08205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BLE401_RS08220	COG0430	RNA-3'-phosphate cyclase activity
BLE401_RS08235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BLE401_RS08240	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BLE401_RS08250	COG0330	HflC and HflK could
BLE401_RS08255	COG0330	HflC and HflK could
BLE401_RS08275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BLE401_RS08280	COG1923	regulation of RNA biosynthetic process
BLE401_RS08285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BLE401_RS08290	COG1459	type II secretion system
BLE401_RS08305	COG0494	nUDIX hydrolase
BLE401_RS08315	COG0588	phosphoglycerate mutase activity
BLE401_RS08325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BLE401_RS08330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BLE401_RS08335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BLE401_RS08345	COG0825	malonyl-CoA metabolic process
BLE401_RS08360	COG0557	exoribonuclease II activity
BLE401_RS08390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BLE401_RS08405	COG2165	general secretion pathway protein
BLE401_RS08410	COG0484	heat shock protein binding
BLE401_RS08435	COG0504	CTP synthase activity
BLE401_RS08440	COG2084	Dehydrogenase
BLE401_RS08450	COG1346	cytolysis
BLE401_RS08465	COG2202	Pas domain
BLE401_RS08465	COG2205	protein histidine kinase activity
BLE401_RS08490	COG0752	glycyl-tRNA synthetase alpha subunit
BLE401_RS08495	COG0751	glycine-tRNA ligase activity
BLE401_RS08500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BLE401_RS08510	COG1705	Flagellar rod assembly protein muramidase FlgJ
BLE401_RS08510	COG1388	LysM domain
BLE401_RS08515	COG4942	peptidase
BLE401_RS08530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BLE401_RS08555	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BLE401_RS08565	COG1138	Cytochrome C-type biogenesis protein
BLE401_RS08575	COG2217	Heavy metal translocating P-type atpase
BLE401_RS08585	COG1648	precorrin-2 dehydrogenase activity
BLE401_RS08585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BLE401_RS08590	COG0425	Belongs to the sulfur carrier protein TusA family
BLE401_RS08595	COG2210	Belongs to the sulfur carrier protein TusA family
BLE401_RS08600	COG0328	RNA-DNA hybrid ribonuclease activity
BLE401_RS08610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BLE401_RS08630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLE401_RS08635	COG0589	response to stress
BLE401_RS08650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BLE401_RS08650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BLE401_RS08655	COG0179	Fumarylacetoacetate (FAA) hydrolase
BLE401_RS08660	COG3932	Exopolysaccharide synthesis, ExoD
BLE401_RS08670	COG1196	nuclear chromosome segregation
BLE401_RS08670	COG0739	heme binding
BLE401_RS08670	COG0741	lytic transglycosylase activity
BLE401_RS08675	COG0604	alcohol dehydrogenase
BLE401_RS08690	COG3243	poly(R)-hydroxyalkanoic acid synthase
BLE401_RS08695	COG0515	serine threonine protein kinase
BLE401_RS08695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS08705	COG2902	Dehydrogenase
BLE401_RS08715	COG0573	inorganic phosphate transmembrane transporter activity
BLE401_RS08720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BLE401_RS08725	COG0704	Plays a role in the regulation of phosphate uptake
BLE401_RS08745	COG1960	acyl-CoA dehydrogenase activity
BLE401_RS08755	COG3707	response regulator
BLE401_RS08760	COG1116	anion transmembrane transporter activity
BLE401_RS08760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BLE401_RS08765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BLE401_RS08770	COG1116	anion transmembrane transporter activity
BLE401_RS08775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BLE401_RS08780	COG2146	nitrite reductase [NAD(P)H] activity
BLE401_RS08785	COG0243	molybdopterin cofactor binding
BLE401_RS08795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BLE401_RS08805	COG1562	ergosterol biosynthetic process
BLE401_RS08810	COG0330	HflC and HflK could
BLE401_RS08815	COG0390	transport system, permease component
BLE401_RS08825	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
BLE401_RS08840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BLE401_RS08845	COG0693	protein deglycase activity
BLE401_RS08855	COG1216	Glycosyl transferase, family 2
BLE401_RS08855	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS08865	COG0791	NLP P60 protein
BLE401_RS08870	COG0450	alkyl hydroperoxide reductase
BLE401_RS08895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BLE401_RS08900	COG1832	CoA-binding protein
BLE401_RS08930	COG0166	Belongs to the GPI family
BLE401_RS08955	COG4232	protein-disulfide reductase activity
BLE401_RS08960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BLE401_RS08980	COG4191	Histidine kinase
BLE401_RS09020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS09025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLE401_RS09040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BLE401_RS09060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BLE401_RS09065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BLE401_RS09085	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS09090	COG0367	asparagine synthase
BLE401_RS09095	COG0463	Glycosyl transferase, family 2
BLE401_RS09105	COG4106	trans-aconitate 2-methyltransferase activity
BLE401_RS09115	COG5001	Diguanylate cyclase
BLE401_RS09115	COG3300	MHYT domain
BLE401_RS09120	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BLE401_RS09125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLE401_RS09130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLE401_RS09135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLE401_RS09140	COG0649	NAD binding
BLE401_RS09145	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BLE401_RS09155	COG1034	ATP synthesis coupled electron transport
BLE401_RS09160	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BLE401_RS09165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLE401_RS09180	COG0713	ATP synthesis coupled electron transport
BLE401_RS09195	COG1007	ATP synthesis coupled electron transport
BLE401_RS09200	COG1555	photosystem II stabilization
BLE401_RS09205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BLE401_RS09210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BLE401_RS09230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BLE401_RS09240	COG0356	it plays a direct role in the translocation of protons across the membrane
BLE401_RS09245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BLE401_RS09250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BLE401_RS09255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BLE401_RS09260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BLE401_RS09265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BLE401_RS09270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BLE401_RS09275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BLE401_RS09280	COG3284	Transcriptional regulator
BLE401_RS09295	COG3012	SEC-C Motif Domain Protein
BLE401_RS09300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BLE401_RS09305	COG1127	ABC transporter
BLE401_RS09315	COG0784	Response regulator, receiver
BLE401_RS09315	COG2198	Histidine kinase
BLE401_RS09315	COG2205	protein histidine kinase activity
BLE401_RS09330	COG0501	Belongs to the peptidase M48B family
BLE401_RS09340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS09340	COG0515	serine threonine protein kinase
BLE401_RS09570	COG2842	Transposition protein
BLE401_RS09575	COG2801	Transposase and inactivated derivatives
BLE401_RS09640	COG3275	phosphorelay sensor kinase activity
BLE401_RS09665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BLE401_RS09670	COG0085	RNA polymerase activity
BLE401_RS09675	COG0222	ribosome binding
BLE401_RS09680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BLE401_RS09685	COG0081	regulation of translation
BLE401_RS09690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BLE401_RS09700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BLE401_RS09710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BLE401_RS09740	COG1218	3'(2'),5'-bisphosphate nucleotidase
BLE401_RS09760	COG1573	uracil-dna glycosylase
BLE401_RS09790	COG0784	Response regulator, receiver
BLE401_RS09790	COG2205	protein histidine kinase activity
BLE401_RS09795	COG2203	Gaf domain
BLE401_RS09795	COG3706	GGDEF domain
BLE401_RS09795	COG4251	negative regulation of phosphorylation
BLE401_RS09795	COG5001	Diguanylate cyclase
BLE401_RS09810	COG3302	dmso reductase anchor subunit
BLE401_RS09815	COG0437	4 iron, 4 sulfur cluster binding
BLE401_RS09820	COG0243	molybdopterin cofactor binding
BLE401_RS09825	COG0552	protein localization to endoplasmic reticulum
BLE401_RS09835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS09835	COG0515	serine threonine protein kinase
BLE401_RS09860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BLE401_RS09875	COG0019	diaminopimelate decarboxylase activity
BLE401_RS09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BLE401_RS09940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BLE401_RS09965	COG0523	cobalamin synthesis protein
BLE401_RS09975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BLE401_RS09985	COG0033	Phosphoglucomutase
BLE401_RS09995	COG0723	plastoquinol--plastocyanin reductase activity
BLE401_RS10000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BLE401_RS10005	COG2857	Cytochrome c1
BLE401_RS10010	COG2969	positive regulation of protein catabolic process
BLE401_RS10025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BLE401_RS10030	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BLE401_RS10035	COG2226	methyltransferase
BLE401_RS10045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BLE401_RS10050	COG4137	Cytochrome C assembly protein
BLE401_RS10065	COG0768	penicillin binding
BLE401_RS10070	COG3437	response regulator, receiver
BLE401_RS10070	COG0784	Response regulator, receiver
BLE401_RS10075	COG1519	Transferase
BLE401_RS10080	COG0183	Belongs to the thiolase family
BLE401_RS10090	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS10145	COG0237	dephospho-CoA kinase activity
BLE401_RS10150	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BLE401_RS10175	COG0840	transmembrane signaling receptor activity
BLE401_RS10180	COG2198	Histidine kinase
BLE401_RS10180	COG0784	Response regulator, receiver
BLE401_RS10180	COG0643	Histidine kinase
BLE401_RS10210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BLE401_RS10220	COG0443	Heat shock 70 kDa protein
BLE401_RS10230	COG0791	NLP P60 protein
BLE401_RS10240	COG1846	Transcriptional regulator
BLE401_RS10245	COG2703	oxygen carrier activity
BLE401_RS10255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BLE401_RS10260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BLE401_RS10265	COG1538	Outer membrane efflux protein
BLE401_RS10270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BLE401_RS10290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BLE401_RS10295	COG2813	Specifically methylates the guanine in position
BLE401_RS10295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BLE401_RS10305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BLE401_RS10310	COG0254	rRNA binding
BLE401_RS10325	COG1131	(ABC) transporter
BLE401_RS10335	COG0602	queuosine metabolic process
BLE401_RS10340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BLE401_RS10345	COG0484	heat shock protein binding
BLE401_RS10350	COG0443	Heat shock 70 kDa protein
BLE401_RS10355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BLE401_RS10360	COG1420	regulation of RNA biosynthetic process
BLE401_RS10375	COG0708	Exodeoxyribonuclease III
BLE401_RS10385	COG0753	catalase activity
BLE401_RS10390	COG2010	Cytochrome c
BLE401_RS10395	COG2205	protein histidine kinase activity
BLE401_RS10395	COG4999	Histidine kinase
BLE401_RS10395	COG3850	Histidine kinase
BLE401_RS10395	COG3437	response regulator, receiver
BLE401_RS10430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BLE401_RS10485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BLE401_RS10490	COG2814	Major facilitator Superfamily
BLE401_RS10505	COG0463	Glycosyl transferase, family 2
BLE401_RS10510	COG1965	Belongs to the frataxin family
BLE401_RS10525	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS10555	COG4783	chaperone-mediated protein folding
BLE401_RS10565	COG1131	(ABC) transporter
BLE401_RS10580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BLE401_RS10595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BLE401_RS10610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BLE401_RS10640	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BLE401_RS10655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BLE401_RS10660	COG3383	formate dehydrogenase (NAD+) activity
BLE401_RS10670	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BLE401_RS10685	COG3158	transport of potassium into the cell
BLE401_RS10700	COG0084	hydrolase, TatD family'
BLE401_RS10705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BLE401_RS10715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BLE401_RS10720	COG0464	growth
BLE401_RS10740	COG3411	Ferredoxin
BLE401_RS10755	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
BLE401_RS10770	COG2304	oxidoreductase activity
BLE401_RS10815	COG0513	Belongs to the DEAD box helicase family
BLE401_RS10825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BLE401_RS10840	COG1136	(ABC) transporter
BLE401_RS10845	COG4591	ABC-type transport system involved in lipoprotein release permease component
BLE401_RS10850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BLE401_RS10865	COG1131	(ABC) transporter
BLE401_RS10870	COG0842	Transport permease protein
BLE401_RS10875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BLE401_RS10880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BLE401_RS10885	COG1862	Preprotein translocase
BLE401_RS10905	COG1024	Enoyl-CoA hydratase
BLE401_RS10940	COG2177	Part of the ABC transporter FtsEX involved in
BLE401_RS10950	COG2003	Belongs to the UPF0758 family
BLE401_RS10975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BLE401_RS10980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BLE401_RS10985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BLE401_RS10990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BLE401_RS11000	COG2201	protein-glutamate methylesterase activity
BLE401_RS11015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BLE401_RS11015	COG0616	signal peptide processing
BLE401_RS11115	COG0167	dihydroorotate dehydrogenase activity
BLE401_RS11125	COG1643	Atp-dependent helicase
BLE401_RS11135	COG1858	cytochrome C peroxidase
BLE401_RS11155	COG0583	DNA-binding transcription factor activity
BLE401_RS11160	COG0784	Response regulator, receiver
BLE401_RS11160	COG2205	protein histidine kinase activity
BLE401_RS11165	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BLE401_RS11190	COG3258	Cytochrome c
BLE401_RS11195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS11200	COG0714	Associated with various cellular activities
BLE401_RS11210	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BLE401_RS11225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BLE401_RS11230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BLE401_RS11240	COG3245	cytochrome
BLE401_RS11265	COG2205	protein histidine kinase activity
BLE401_RS11265	COG0784	Response regulator, receiver
BLE401_RS11285	COG5464	transposase or invertase
BLE401_RS11305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLE401_RS11320	COG0795	lipopolysaccharide-transporting ATPase activity
BLE401_RS11335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BLE401_RS11365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLE401_RS11380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BLE401_RS11385	COG2894	cell division
BLE401_RS11390	COG0850	regulation of cytokinetic process
BLE401_RS11450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BLE401_RS11455	COG3384	dioxygenase
BLE401_RS11460	COG1741	Belongs to the pirin family
BLE401_RS11470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BLE401_RS11475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BLE401_RS11525	COG2319	Wd-40 repeat
BLE401_RS11525	COG4249	Peptidase C14 caspase catalytic subunit p20
BLE401_RS11540	COG1012	belongs to the aldehyde dehydrogenase family
BLE401_RS11570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BLE401_RS11585	COG0077	Prephenate dehydratase
BLE401_RS11585	COG1605	Chorismate mutase
BLE401_RS11590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BLE401_RS11610	COG0582	viral genome integration into host DNA
BLE401_RS11680	COG0640	Transcriptional regulator
BLE401_RS11690	COG2890	protein-(glutamine-N5) methyltransferase activity
BLE401_RS11740	COG2198	Histidine kinase
BLE401_RS11740	COG0643	Histidine kinase
BLE401_RS11740	COG0784	Response regulator, receiver
BLE401_RS11785	COG2205	protein histidine kinase activity
BLE401_RS11785	COG5002	protein histidine kinase activity
BLE401_RS11785	COG0784	Response regulator, receiver
BLE401_RS11790	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS11805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BLE401_RS11805	COG0047	phosphoribosylformylglycinamidine synthase activity
BLE401_RS11810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BLE401_RS11820	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BLE401_RS11825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BLE401_RS11845	COG2319	Wd-40 repeat
BLE401_RS11845	COG4249	Peptidase C14 caspase catalytic subunit p20
BLE401_RS11860	COG2308	Evidence 4 Homologs of previously reported genes of
BLE401_RS11910	COG0650	Formate hydrogenlyase subunit 4
BLE401_RS11955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLE401_RS11960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BLE401_RS11965	COG4172	Belongs to the ABC transporter superfamily
BLE401_RS11975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BLE401_RS11985	COG1280	lysine exporter protein (LysE YggA)
BLE401_RS12010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BLE401_RS12020	COG3180	Ammonia monooxygenase
BLE401_RS12025	COG1234	tRNA 3'-trailer cleavage
BLE401_RS12030	COG0745	RESPONSE REGULATOR receiver
BLE401_RS12040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BLE401_RS12055	COG2183	response to ionizing radiation
BLE401_RS12060	COG3300	MHYT domain
BLE401_RS12060	COG5001	Diguanylate cyclase
BLE401_RS12070	COG0720	synthase
BLE401_RS12085	COG1360	Flagellar Motor Protein
BLE401_RS12110	COG4555	ABC transporter
BLE401_RS12150	COG1064	alcohol dehydrogenase
BLE401_RS12200	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BLE401_RS12230	COG1733	regulation of RNA biosynthetic process
BLE401_RS12235	COG0702	epimerase
BLE401_RS12270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BLE401_RS12275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BLE401_RS12285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BLE401_RS12290	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BLE401_RS12330	COG0582	viral genome integration into host DNA
BLE401_RS12340	COG2337	Toxic component of a toxin-antitoxin (TA) module
BLE401_RS12360	COG2208	phosphoserine phosphatase activity
BLE401_RS12375	COG1993	acr, cog1993
BLE401_RS12380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BLE401_RS12390	COG0601	transmembrane transport
BLE401_RS12405	COG3909	cytochrome
BLE401_RS12450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BLE401_RS12455	COG1309	transcriptional regulator
BLE401_RS12490	COG1842	Phage shock protein A
BLE401_RS12505	COG0606	chelatase, subunit chli
BLE401_RS12520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS12530	COG0863	Belongs to the N(4) N(6)-methyltransferase family
BLE401_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS12555	COG2319	Wd-40 repeat
BLE401_RS12555	COG5635	Nacht domain
BLE401_RS12580	COG0410	ABC transporter
BLE401_RS12605	COG1022	Amp-dependent synthetase and ligase
BLE401_RS12615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BLE401_RS12625	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BLE401_RS12630	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BLE401_RS12680	COG4999	Histidine kinase
BLE401_RS12680	COG3850	Histidine kinase
BLE401_RS12680	COG3437	response regulator, receiver
BLE401_RS12680	COG2205	protein histidine kinase activity
BLE401_RS12685	COG2205	protein histidine kinase activity
BLE401_RS12695	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BLE401_RS12710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BLE401_RS12715	COG4208	sulfate ABC transporter
BLE401_RS12720	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BLE401_RS12750	COG2354	Protein conserved in bacteria
BLE401_RS12755	COG0352	thiamine-phosphate diphosphorylase activity
BLE401_RS12760	COG0564	pseudouridine synthase activity
BLE401_RS12790	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BLE401_RS12800	COG3550	peptidyl-serine autophosphorylation
BLE401_RS12810	COG4953	penicillin-binding protein 1C
BLE401_RS12820	COG1858	cytochrome C peroxidase
BLE401_RS12830	COG1408	metallophosphoesterase
BLE401_RS12875	COG0742	ribosomal rna small subunit methyltransferase
BLE401_RS12890	COG0667	Aldo Keto reductase
BLE401_RS12930	COG0459	protein refolding
BLE401_RS12935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BLE401_RS12945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BLE401_RS12950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BLE401_RS12960	COG0018	arginyl-trna synthetase
BLE401_RS12965	COG1686	Belongs to the peptidase S11 family
BLE401_RS12970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BLE401_RS12975	COG2951	lytic endotransglycosylase activity
BLE401_RS12980	COG0772	Belongs to the SEDS family
BLE401_RS12985	COG4566	intracellular signal transduction
BLE401_RS12995	COG0280	phosphate acetyltransferase
BLE401_RS12995	COG0281	malic enzyme
BLE401_RS13010	COG2205	protein histidine kinase activity
BLE401_RS13015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BLE401_RS13015	COG0543	2 iron, 2 sulfur cluster binding
BLE401_RS13035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BLE401_RS13045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BLE401_RS13050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BLE401_RS13055	COG0804	urea catabolic process
BLE401_RS13060	COG0832	Belongs to the urease beta subunit family
BLE401_RS13065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BLE401_RS13065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BLE401_RS13080	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BLE401_RS13090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BLE401_RS13125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BLE401_RS13130	COG1040	competence protein
BLE401_RS13155	COG5002	protein histidine kinase activity
BLE401_RS13175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS13180	COG0312	modulator of DNA gyrase
BLE401_RS13195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BLE401_RS13200	COG3977	Valine--pyruvate aminotransferase
BLE401_RS13220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BLE401_RS13225	COG0795	lipopolysaccharide-transporting ATPase activity
BLE401_RS13235	COG1185	polyribonucleotide nucleotidyltransferase activity
BLE401_RS13240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BLE401_RS13255	COG0758	DNA mediated transformation
BLE401_RS13260	COG2922	Belongs to the Smg family
BLE401_RS13275	COG0367	asparagine synthase
BLE401_RS13280	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS13285	COG3842	ATPase activity
BLE401_RS13290	COG0745	RESPONSE REGULATOR receiver
BLE401_RS13295	COG2205	protein histidine kinase activity
BLE401_RS13305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BLE401_RS13310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BLE401_RS13320	COG0300	oxidoreductase activity
BLE401_RS13330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS13340	COG2308	Evidence 4 Homologs of previously reported genes of
BLE401_RS13340	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BLE401_RS13375	COG2304	oxidoreductase activity
BLE401_RS13400	COG3540	Alkaline phosphatase
BLE401_RS13405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BLE401_RS13410	COG0509	glycine decarboxylation via glycine cleavage system
BLE401_RS13415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BLE401_RS13425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BLE401_RS13425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BLE401_RS13430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BLE401_RS13435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BLE401_RS13470	COG0009	L-threonylcarbamoyladenylate synthase
BLE401_RS13475	COG1994	Peptidase M50
BLE401_RS13480	COG0439	Biotin carboxylase
BLE401_RS13485	COG0511	ligase activity, forming carbon-carbon bonds
BLE401_RS13490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BLE401_RS13495	COG2815	serine threonine protein kinase
BLE401_RS13495	COG0515	serine threonine protein kinase
BLE401_RS13510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BLE401_RS13515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BLE401_RS13520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BLE401_RS13530	COG2274	protein secretion by the type I secretion system
BLE401_RS13545	COG4166	transmembrane transport
BLE401_RS13560	COG0737	Belongs to the 5'-nucleotidase family
BLE401_RS13565	COG2205	protein histidine kinase activity
BLE401_RS13580	COG0519	Catalyzes the synthesis of GMP from XMP
BLE401_RS13580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BLE401_RS13590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BLE401_RS13615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLE401_RS13620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLE401_RS13645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BLE401_RS13650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BLE401_RS13660	COG0544	peptidyl-prolyl cis-trans isomerase activity
BLE401_RS13675	COG0859	PFAM glycosyl transferase family 9
BLE401_RS13685	COG2201	protein-glutamate methylesterase activity
BLE401_RS13690	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BLE401_RS13740	COG3038	cytochrome b561
BLE401_RS13755	COG0557	exoribonuclease II activity
BLE401_RS13765	COG1450	Type ii and iii secretion system protein
BLE401_RS13770	COG1459	type II secretion system
BLE401_RS13775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BLE401_RS13785	COG2369	cell adhesion
BLE401_RS13790	COG0525	valine-tRNA ligase activity
BLE401_RS13795	COG0183	Belongs to the thiolase family
BLE401_RS13805	COG0205	6-phosphofructokinase activity
BLE401_RS13820	COG0193	aminoacyl-tRNA hydrolase activity
BLE401_RS13825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BLE401_RS13830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BLE401_RS13840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BLE401_RS13845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BLE401_RS13855	COG2814	Major facilitator Superfamily
BLE401_RS13860	COG0203	ribosomal protein L17
BLE401_RS13865	COG0202	RNA polymerase activity
BLE401_RS13870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BLE401_RS13875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BLE401_RS13880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BLE401_RS13885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BLE401_RS13890	COG0201	protein transport
BLE401_RS13895	COG0200	Binds to the 23S rRNA
BLE401_RS13900	COG1841	ribosomal large subunit assembly
BLE401_RS13910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BLE401_RS13915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BLE401_RS13925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BLE401_RS13930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BLE401_RS13935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BLE401_RS13940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BLE401_RS13945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BLE401_RS13960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BLE401_RS13970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BLE401_RS13975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BLE401_RS13980	COG0089	rRNA binding
BLE401_RS13985	COG0088	Forms part of the polypeptide exit tunnel
BLE401_RS13990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BLE401_RS13995	COG0051	transcription antitermination factor activity, RNA binding
BLE401_RS14000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BLE401_RS14005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BLE401_RS14010	COG0049	tRNA binding
BLE401_RS14015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BLE401_RS14020	COG4206	TonB-dependent receptor
BLE401_RS14030	COG0612	Peptidase, M16
BLE401_RS14035	COG0612	Peptidase, M16
BLE401_RS14050	COG2146	nitrite reductase [NAD(P)H] activity
BLE401_RS14055	COG3956	TIGRFAM MazG family protein
BLE401_RS14070	COG3850	Histidine kinase
BLE401_RS14070	COG4999	Histidine kinase
BLE401_RS14070	COG2205	protein histidine kinase activity
BLE401_RS14070	COG3437	response regulator, receiver
BLE401_RS14090	COG1858	cytochrome C peroxidase
BLE401_RS14100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BLE401_RS14105	COG3162	membrane
BLE401_RS14110	COG0629	single-stranded DNA binding
BLE401_RS14115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BLE401_RS14115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BLE401_RS14120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS14125	COG0830	nickel cation binding
BLE401_RS14130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BLE401_RS14150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BLE401_RS14180	COG2814	Major facilitator Superfamily
BLE401_RS14205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BLE401_RS14205	COG0116	Belongs to the methyltransferase superfamily
BLE401_RS14210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BLE401_RS14215	COG0729	surface antigen
BLE401_RS14225	COG1074	ATP-dependent DNA helicase activity
BLE401_RS14230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BLE401_RS14235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BLE401_RS14245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BLE401_RS14250	COG1160	GTP binding
BLE401_RS14260	COG0604	alcohol dehydrogenase
BLE401_RS14285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BLE401_RS14290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BLE401_RS14295	COG0271	Belongs to the BolA IbaG family
BLE401_RS14320	COG1216	Glycosyl transferase, family 2
BLE401_RS14320	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS14340	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BLE401_RS14345	COG5002	protein histidine kinase activity
BLE401_RS14355	COG4536	flavin adenine dinucleotide binding
BLE401_RS14360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BLE401_RS14365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BLE401_RS14390	COG0651	ATP synthesis coupled electron transport
BLE401_RS14410	COG2204	response regulator
BLE401_RS14420	COG4770	biotin carboxylase activity
BLE401_RS14425	COG0306	phosphate transporter
BLE401_RS14465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BLE401_RS14475	COG0776	regulation of translation
BLE401_RS14480	COG0072	phenylalanine-tRNA ligase activity
BLE401_RS14490	COG0284	orotidine-5'-phosphate decarboxylase activity
BLE401_RS14495	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BLE401_RS14500	COG0776	regulation of translation
BLE401_RS14510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BLE401_RS14515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BLE401_RS14520	COG0287	Prephenate dehydrogenase
BLE401_RS14525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BLE401_RS14530	COG2226	methyltransferase
BLE401_RS14535	COG0037	tRNA processing
BLE401_RS14540	COG1534	Rna-binding protein
BLE401_RS14560	COG2239	Acts as a magnesium transporter
BLE401_RS14585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BLE401_RS14585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BLE401_RS14650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS14660	COG0297	glycogen (starch) synthase activity
BLE401_RS14665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS14670	COG2226	methyltransferase
BLE401_RS14685	COG1388	LysM domain
BLE401_RS14685	COG4641	Protein conserved in bacteria
BLE401_RS14700	COG0438	transferase activity, transferring glycosyl groups
BLE401_RS14710	COG2226	methyltransferase
BLE401_RS14775	COG0251	oxidation-reduction process
BLE401_RS14795	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BLE401_RS14795	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BLE401_RS14795	COG1703	isobutyryl-CoA mutase activity
BLE401_RS14800	COG0784	Response regulator, receiver
BLE401_RS14800	COG2205	protein histidine kinase activity
BLE401_RS14805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BLE401_RS14830	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BLE401_RS14840	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BLE401_RS14840	COG3261	NADH dehydrogenase
BLE401_RS14850	COG1490	D-aminoacyl-tRNA deacylase activity
BLE401_RS14860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLE401_RS14870	COG2350	Protein conserved in bacteria
BLE401_RS14880	COG3088	subunit of a heme lyase
BLE401_RS14885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BLE401_RS14890	COG3842	ATPase activity
BLE401_RS14895	COG0725	ABC transporter, periplasmic molybdate-binding protein
BLE401_RS14900	COG4149	molybdate abc transporter
BLE401_RS14920	COG5001	Diguanylate cyclase
BLE401_RS14945	COG0028	Belongs to the TPP enzyme family
BLE401_RS14955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BLE401_RS14960	COG1183	phosphatidylcholine synthase activity
BLE401_RS14980	COG2010	Cytochrome c
BLE401_RS15050	COG0489	protein tyrosine kinase activity
BLE401_RS15060	COG0424	maF-like protein
BLE401_RS15065	COG1399	metal-binding, possibly nucleic acid-binding protein
BLE401_RS15070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BLE401_RS15075	COG0416	fatty acid biosynthetic process
BLE401_RS15080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BLE401_RS15090	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS15095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BLE401_RS15100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BLE401_RS15110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BLE401_RS15120	COG0247	lactate metabolic process
BLE401_RS15125	COG1592	Rubrerythrin
BLE401_RS15135	COG2915	High frequency lysogenization protein hflD homolog
BLE401_RS15150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BLE401_RS15155	COG0131	Imidazoleglycerol-phosphate dehydratase
BLE401_RS15160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BLE401_RS15225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BLE401_RS15255	COG2304	oxidoreductase activity
BLE401_RS15260	COG0024	Methionine aminopeptidase
BLE401_RS15265	COG0052	Belongs to the universal ribosomal protein uS2 family
BLE401_RS15270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BLE401_RS15275	COG0528	UMP kinase activity
BLE401_RS15280	COG0233	cytoplasmic translational termination
BLE401_RS15285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BLE401_RS15295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BLE401_RS15300	COG0750	zinc metalloprotease
BLE401_RS15305	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BLE401_RS15315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BLE401_RS15320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BLE401_RS15325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BLE401_RS15330	COG0268	Binds directly to 16S ribosomal RNA
BLE401_RS15335	COG1229	Formylmethanofuran dehydrogenase subunit A
BLE401_RS15340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BLE401_RS15350	COG5635	Nacht domain
BLE401_RS15350	COG2319	Wd-40 repeat
BLE401_RS15360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BLE401_RS15365	COG2205	protein histidine kinase activity
BLE401_RS15365	COG3850	Histidine kinase
BLE401_RS15365	COG3437	response regulator, receiver
BLE401_RS15365	COG4999	Histidine kinase
BLE401_RS15415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLE401_RS15450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BLE401_RS15465	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BLE401_RS15470	COG0745	RESPONSE REGULATOR receiver
BLE401_RS15485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BLE401_RS15500	COG1120	ATPase activity
BLE401_RS15545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BLE401_RS15555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BLE401_RS15570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BLE401_RS15585	COG2333	competence protein COMEC
BLE401_RS15585	COG0658	competence protein
BLE401_RS15615	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BLE401_RS15620	COG0351	phosphomethylpyrimidine kinase
BLE401_RS15625	COG4597	amino acid ABC transporter
BLE401_RS15630	COG0765	amino acid transport
BLE401_RS15640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BLE401_RS15645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BLE401_RS15660	COG2974	May be involved in recombination
BLE401_RS15665	COG0598	Magnesium transport protein CorA
BLE401_RS15690	COG2850	peptidyl-arginine hydroxylation
BLE401_RS15700	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BLE401_RS15705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BLE401_RS15710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BLE401_RS15740	COG0316	Belongs to the HesB IscA family
BLE401_RS15760	COG0633	Ferredoxin
BLE401_RS15765	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS15765	COG0604	alcohol dehydrogenase
BLE401_RS15765	COG3321	synthase
BLE401_RS15770	COG2203	Gaf domain
BLE401_RS15770	COG5001	Diguanylate cyclase
BLE401_RS15770	COG4251	negative regulation of phosphorylation
BLE401_RS15770	COG3706	GGDEF domain
BLE401_RS15775	COG0714	Associated with various cellular activities
BLE401_RS15785	COG2304	oxidoreductase activity
BLE401_RS15790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BLE401_RS15795	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BLE401_RS15815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BLE401_RS15820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BLE401_RS15860	COG2105	PFAM AIG2 family protein
BLE401_RS15935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BLE401_RS15975	COG0194	GDP metabolic process
BLE401_RS15980	COG1561	YicC-like family, N-terminal region
BLE401_RS15985	COG1477	protein flavinylation
BLE401_RS16005	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BLE401_RS16015	COG0181	hydroxymethylbilane synthase activity
BLE401_RS16025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BLE401_RS16050	COG0745	RESPONSE REGULATOR receiver
BLE401_RS16055	COG0642	Histidine kinase
BLE401_RS16075	COG0492	ferredoxin-NADP+ reductase activity
BLE401_RS16080	COG1674	ftsk spoiiie
BLE401_RS16170	COG2205	protein histidine kinase activity
BLE401_RS16175	COG3300	MHYT domain
BLE401_RS16175	COG5001	Diguanylate cyclase
BLE401_RS16180	COG2770	Histidine kinase
BLE401_RS16180	COG2208	phosphoserine phosphatase activity
BLE401_RS16190	COG0493	'glutamate synthase
BLE401_RS16190	COG0543	2 iron, 2 sulfur cluster binding
BLE401_RS16200	COG4651	solute:proton antiporter activity
BLE401_RS16200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BLE401_RS16225	COG1830	Aldolase
BLE401_RS16230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BLE401_RS16240	COG4191	Histidine kinase
BLE401_RS16240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS16245	COG1278	Cold shock
BLE401_RS16250	COG1278	Cold shock
BLE401_RS16255	COG1278	Cold shock
BLE401_RS16260	COG1278	Cold shock
BLE401_RS16265	COG1278	Cold shock
BLE401_RS16270	COG1278	Cold shock
BLE401_RS16275	COG1278	Cold shock
BLE401_RS16290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BLE401_RS16300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BLE401_RS16305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BLE401_RS16335	COG0714	Associated with various cellular activities
BLE401_RS16355	COG1366	Belongs to the anti-sigma-factor antagonist family
BLE401_RS16375	COG0045	succinate-CoA ligase (ADP-forming) activity
BLE401_RS16380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BLE401_RS16385	COG0347	Belongs to the P(II) protein family
BLE401_RS16390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BLE401_RS16420	COG4969	Belongs to the N-Me-Phe pilin family
BLE401_RS16455	COG0426	domain, Protein
BLE401_RS16460	COG0633	Ferredoxin
BLE401_RS16465	COG0633	Ferredoxin
BLE401_RS16495	COG0542	response to heat
BLE401_RS16515	COG0651	ATP synthesis coupled electron transport
BLE401_RS16520	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BLE401_RS16530	COG0779	Required for maturation of 30S ribosomal subunits
BLE401_RS16535	COG0195	Participates in both transcription termination and antitermination
BLE401_RS16540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BLE401_RS16545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BLE401_RS16550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BLE401_RS16570	COG2205	protein histidine kinase activity
BLE401_RS16570	COG0784	Response regulator, receiver
BLE401_RS16570	COG5002	protein histidine kinase activity
BLE401_RS16600	COG2815	serine threonine protein kinase
BLE401_RS16600	COG0515	serine threonine protein kinase
BLE401_RS16610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BLE401_RS16620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BLE401_RS16625	COG2267	carboxylic ester hydrolase activity
BLE401_RS16650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BLE401_RS16655	COG1666	GTP binding
BLE401_RS16660	COG0335	large ribosomal subunit rRNA binding
BLE401_RS16670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BLE401_RS16720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BLE401_RS16740	COG0175	sulfate reduction
BLE401_RS16750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BLE401_RS16750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BLE401_RS16755	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BLE401_RS16760	COG0501	Belongs to the peptidase M48B family
BLE401_RS16825	COG0811	peptide transport
BLE401_RS16830	COG0848	biopolymer transport protein
BLE401_RS16835	COG1663	tetraacyldisaccharide 4'-kinase activity
BLE401_RS16840	COG2835	tetraacyldisaccharide 4'-kinase activity
BLE401_RS16845	COG0446	pyridine nucleotide-disulphide oxidoreductase
BLE401_RS16880	COG4239	(ABC) transporter, permease
BLE401_RS16885	COG4174	ABC transporter (Permease)
BLE401_RS16890	COG1331	Highly conserved protein containing a thioredoxin domain
BLE401_RS16895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BLE401_RS16910	COG0459	protein refolding
BLE401_RS16915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BLE401_RS16920	COG0501	Belongs to the peptidase M48B family
BLE401_RS16935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BLE401_RS16955	COG4206	TonB-dependent receptor
BLE401_RS16960	COG0668	transmembrane transport
BLE401_RS16985	COG0772	Belongs to the SEDS family
BLE401_RS17040	COG0735	belongs to the Fur family
BLE401_RS17075	COG1872	DUF167
BLE401_RS17100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BLE401_RS17105	COG1702	phosphate starvation-inducible protein PhoH
BLE401_RS17115	COG4535	Mg2 and Co2 transporter CorC
BLE401_RS17150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BLE401_RS17160	COG0714	Associated with various cellular activities
BLE401_RS17170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BLE401_RS17200	COG1335	isochorismatase
BLE401_RS17215	COG2917	probably involved in intracellular septation
BLE401_RS17220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLE401_RS17230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BLE401_RS17245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BLE401_RS17280	COG0515	serine threonine protein kinase
BLE401_RS17280	COG2815	serine threonine protein kinase
BLE401_RS17285	COG1530	ribonuclease E activity
BLE401_RS17290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLE401_RS17300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BLE401_RS17305	COG0308	aminopeptidase N
BLE401_RS17325	COG0784	Response regulator, receiver
BLE401_RS17325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS17325	COG2198	Histidine kinase
BLE401_RS17325	COG2205	protein histidine kinase activity
BLE401_RS17340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BLE401_RS17355	COG0495	leucyl-tRNA aminoacylation
BLE401_RS17370	COG0741	lytic transglycosylase activity
BLE401_RS17385	COG1678	Uncharacterized ACR, COG1678
BLE401_RS17390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BLE401_RS17395	COG0540	Belongs to the ATCase OTCase family
BLE401_RS17400	COG1509	lysine 2,3-aminomutase activity
BLE401_RS17405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BLE401_RS17410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BLE401_RS17415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BLE401_RS17420	COG2205	protein histidine kinase activity
BLE401_RS17420	COG0784	Response regulator, receiver
BLE401_RS17420	COG5002	protein histidine kinase activity
BLE401_RS17465	COG3260	NADH ubiquinone oxidoreductase 20
BLE401_RS17490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BLE401_RS17490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BLE401_RS17525	COG0137	argininosuccinate synthase activity
BLE401_RS17555	COG1595	DNA-templated transcription, initiation
BLE401_RS17570	COG2205	protein histidine kinase activity
BLE401_RS17570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLE401_RS17575	COG1446	asparaginase
BLE401_RS17580	COG0154	amidase activity
BLE401_RS17590	COG1077	Cell shape determining protein MreB Mrl
BLE401_RS17595	COG1792	Involved in formation and maintenance of cell shape
BLE401_RS17600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BLE401_RS17605	COG0754	glutathionylspermidine amidase activity
BLE401_RS17630	COG1028	Short-chain dehydrogenase reductase Sdr
BLE401_RS17655	COG2204	response regulator
BLE401_RS17660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLE401_RS17665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BLE401_RS17675	COG0631	protein serine/threonine phosphatase activity
BLE401_RS17685	COG4215	(ABC) transporter
BLE401_RS17695	COG0424	maF-like protein
BLE401_RS17700	COG0436	Aminotransferase
BLE401_RS17725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BLE401_RS17730	COG0326	Molecular chaperone. Has ATPase activity
BLE401_RS17745	COG2258	MOSC domain
BLE401_RS17750	COG0134	indole-3-glycerol-phosphate synthase activity
BLE401_RS17785	COG2205	protein histidine kinase activity
BLE401_RS17790	COG2154	pterin-4-alpha-carbinolamine dehydratase
BLE401_RS17810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BLE401_RS17825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BLE401_RS17850	COG0058	SHG alpha-glucan phosphorylase activity
BLE401_RS17870	COG2224	Isocitrate lyase
BLE401_RS17875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BLE401_RS17885	COG0583	DNA-binding transcription factor activity
BLE401_RS17895	COG0585	pseudouridine synthase activity
BLE401_RS17900	COG0628	permease
BLE401_RS17910	COG4771	TonB-dependent receptor
BLE401_RS17915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BLE401_RS17920	COG2208	phosphoserine phosphatase activity
BLE401_RS17920	COG2770	Histidine kinase
BLE401_RS17925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BLE401_RS17930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BLE401_RS17950	COG0174	glutamine synthetase
BLE401_RS17955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BLE401_RS17970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BLE401_RS17990	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BLE401_RS18030	COG1487	ribonuclease activity
BLE401_RS18055	COG2079	MmgE PrpD family protein
BLE401_RS18060	COG0372	Belongs to the citrate synthase family
BLE401_RS18065	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BLE401_RS18085	COG0714	Associated with various cellular activities
BLE401_RS18090	COG5002	protein histidine kinase activity
BLE401_RS18090	COG5001	Diguanylate cyclase
BLE401_RS18095	COG3842	ATPase activity
BLE401_RS18100	COG1176	ABC-type spermidine putrescine transport system, permease component I
BLE401_RS18105	COG1177	transmembrane transport
BLE401_RS18140	COG0516	GMP reductase activity
BLE401_RS18140	COG0517	IMP dehydrogenase activity
BLE401_RS18155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BLE401_RS18165	COG4974	Belongs to the 'phage' integrase family