locus-tag	class	description
CU048_RS00015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CU048_RS00025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU048_RS00025	COG0574	Belongs to the PEP-utilizing enzyme family
CU048_RS00040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CU048_RS00045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CU048_RS00050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CU048_RS00060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU048_RS00085	COG0431	NADPH-dependent FMN reductase
CU048_RS00095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CU048_RS00100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CU048_RS00105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CU048_RS00110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CU048_RS00115	COG0356	it plays a direct role in the translocation of protons across the membrane
CU048_RS00125	COG1196	nuclear chromosome segregation
CU048_RS00130	COG0531	amino acid
CU048_RS00135	COG0330	HflC and HflK could
CU048_RS00140	COG4166	transmembrane transport
CU048_RS00150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU048_RS00155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CU048_RS00165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CU048_RS00175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CU048_RS00190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU048_RS00195	COG0022	dehydrogenase e1 component
CU048_RS00195	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU048_RS00200	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU048_RS00205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU048_RS00210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CU048_RS00215	COG2867	negative regulation of translational initiation
CU048_RS00230	COG4953	penicillin-binding protein 1C
CU048_RS00235	COG2373	Large extracellular alpha-helical protein
CU048_RS00240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CU048_RS00240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CU048_RS00245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU048_RS00255	COG2204	response regulator
CU048_RS00260	COG5000	phosphorelay sensor kinase activity
CU048_RS00265	COG2204	response regulator
CU048_RS00275	COG0670	Belongs to the BI1 family
CU048_RS00285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CU048_RS00285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CU048_RS00300	COG2022	thiamine diphosphate biosynthetic process
CU048_RS00330	COG1074	ATP-dependent DNA helicase activity
CU048_RS00345	COG1595	DNA-templated transcription, initiation
CU048_RS00360	COG0602	queuosine metabolic process
CU048_RS00365	COG0720	synthase
CU048_RS00375	COG1294	oxidase, subunit
CU048_RS00385	COG1012	belongs to the aldehyde dehydrogenase family
CU048_RS00395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CU048_RS00400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CU048_RS00405	COG1183	phosphatidylcholine synthase activity
CU048_RS00410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CU048_RS00415	COG0424	maF-like protein
CU048_RS00420	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CU048_RS00430	COG0625	glutathione transferase activity
CU048_RS00445	COG1686	Belongs to the peptidase S11 family
CU048_RS00460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CU048_RS00470	COG0537	adenosine 5'-monophosphoramidase activity
CU048_RS00480	COG0531	amino acid
CU048_RS00505	COG0538	isocitrate dehydrogenase activity
CU048_RS00530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CU048_RS00545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CU048_RS00550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CU048_RS00560	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CU048_RS00570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CU048_RS00585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CU048_RS00590	COG0328	RNA-DNA hybrid ribonuclease activity
CU048_RS00595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CU048_RS00595	COG0678	peroxiredoxin activity
CU048_RS00605	COG1678	Uncharacterized ACR, COG1678
CU048_RS00620	COG5001	Diguanylate cyclase
CU048_RS00630	COG0612	Peptidase, M16
CU048_RS00655	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CU048_RS00660	COG0109	protoheme IX farnesyltransferase activity
CU048_RS00665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU048_RS00670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CU048_RS00685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CU048_RS00690	COG0509	glycine decarboxylation via glycine cleavage system
CU048_RS00695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CU048_RS00700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CU048_RS00705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CU048_RS00715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CU048_RS00720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CU048_RS00725	COG2218	PFAM glutamate synthase alpha subunit domain protein
CU048_RS00730	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
CU048_RS00735	COG1229	Formylmethanofuran dehydrogenase subunit A
CU048_RS00750	COG0512	Glutamine amidotransferase of anthranilate synthase
CU048_RS00790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CU048_RS00795	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
CU048_RS00820	COG0702	epimerase
CU048_RS00870	COG2080	2 iron, 2 sulfur cluster binding
CU048_RS00875	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CU048_RS00880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU048_RS00885	COG2945	thiolester hydrolase activity
CU048_RS00885	COG0596	Alpha beta hydrolase
CU048_RS00890	COG0741	lytic transglycosylase activity
CU048_RS00895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU048_RS00900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CU048_RS00905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CU048_RS00920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU048_RS00920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU048_RS00925	COG0123	including yeast histone deacetylase and acetoin utilization protein
CU048_RS00950	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CU048_RS00960	COG0375	protein maturation
CU048_RS01065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CU048_RS01075	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU048_RS01075	COG1024	Enoyl-CoA hydratase
CU048_RS01085	COG0183	Belongs to the thiolase family
CU048_RS01090	COG1960	acyl-CoA dehydrogenase activity
CU048_RS01120	COG1201	RNA secondary structure unwinding
CU048_RS01125	COG0633	Ferredoxin
CU048_RS01130	COG0492	ferredoxin-NADP+ reductase activity
CU048_RS01135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CU048_RS01150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CU048_RS01155	COG0343	queuine tRNA-ribosyltransferase activity
CU048_RS01160	COG2951	lytic endotransglycosylase activity
CU048_RS01165	COG2205	protein histidine kinase activity
CU048_RS01170	COG3178	'Phosphotransferase
CU048_RS01180	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CU048_RS01195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CU048_RS01200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU048_RS01200	COG2813	Specifically methylates the guanine in position
CU048_RS01205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU048_RS01210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CU048_RS01220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU048_RS01225	COG1960	acyl-CoA dehydrogenase activity
CU048_RS01230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU048_RS01245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CU048_RS01255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CU048_RS01290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CU048_RS01295	COG0018	arginyl-trna synthetase
CU048_RS01305	COG1278	Cold shock
CU048_RS01335	COG1686	Belongs to the peptidase S11 family
CU048_RS01340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CU048_RS01345	COG0470	DNA polymerase III
CU048_RS01355	COG0084	hydrolase, TatD family'
CU048_RS01360	COG0321	lipoyl(octanoyl) transferase activity
CU048_RS01360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CU048_RS01365	COG1278	Cold shock
CU048_RS01370	COG3956	TIGRFAM MazG family protein
CU048_RS01375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CU048_RS01380	COG1923	regulation of RNA biosynthetic process
CU048_RS01385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU048_RS01390	COG1858	cytochrome C peroxidase
CU048_RS01410	COG1160	GTP binding
CU048_RS01440	COG0596	Alpha beta hydrolase
CU048_RS01455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CU048_RS01455	COG0519	Catalyzes the synthesis of GMP from XMP
CU048_RS01460	COG0300	oxidoreductase activity
CU048_RS01465	COG3394	polysaccharide catabolic process
CU048_RS01470	COG0463	Glycosyl transferase, family 2
CU048_RS01475	COG0728	peptidoglycan biosynthetic process
CU048_RS01505	COG0277	FAD linked oxidase domain protein
CU048_RS01510	COG1942	4-Oxalocrotonate Tautomerase
CU048_RS01520	COG0210	DNA helicase
CU048_RS01550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CU048_RS01555	COG1733	regulation of RNA biosynthetic process
CU048_RS01595	COG0330	HflC and HflK could
CU048_RS01600	COG0330	HflC and HflK could
CU048_RS01605	COG1960	acyl-CoA dehydrogenase activity
CU048_RS01625	COG2267	carboxylic ester hydrolase activity
CU048_RS01655	COG0483	inositol monophosphate 1-phosphatase activity
CU048_RS01670	COG0725	ABC transporter, periplasmic molybdate-binding protein
CU048_RS01710	COG1684	flagellar biosynthetic protein fliR
CU048_RS01715	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CU048_RS01725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CU048_RS01730	COG5443	negative regulation of bacterial-type flagellum assembly
CU048_RS01765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CU048_RS01770	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CU048_RS01775	COG0047	phosphoribosylformylglycinamidine synthase activity
CU048_RS01785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CU048_RS01795	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CU048_RS01800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CU048_RS01805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU048_RS01810	COG0165	Argininosuccinate lyase
CU048_RS01830	COG0019	diaminopimelate decarboxylase activity
CU048_RS01850	COG2086	electron transfer activity
CU048_RS01860	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU048_RS01875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU048_RS01880	COG2967	ApaG domain
CU048_RS01900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CU048_RS01905	COG0285	dihydrofolate synthase activity
CU048_RS01910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CU048_RS01935	COG0477	Major facilitator Superfamily
CU048_RS01940	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CU048_RS01945	COG0248	Ppx GppA phosphatase
CU048_RS01955	COG1573	uracil-dna glycosylase
CU048_RS01960	COG1234	tRNA 3'-trailer cleavage
CU048_RS01975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CU048_RS01985	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CU048_RS01990	COG4942	peptidase
CU048_RS01995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CU048_RS02000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CU048_RS02005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CU048_RS02010	COG0805	protein transport
CU048_RS02015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU048_RS02020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU048_RS02025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CU048_RS02030	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CU048_RS02035	COG1959	2 iron, 2 sulfur cluster binding
CU048_RS02040	COG0563	adenylate kinase activity
CU048_RS02045	COG0201	protein transport
CU048_RS02050	COG0200	Binds to the 23S rRNA
CU048_RS02055	COG1841	ribosomal large subunit assembly
CU048_RS02060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CU048_RS02065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CU048_RS02070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CU048_RS02075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CU048_RS02080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CU048_RS02085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CU048_RS02090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CU048_RS02095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CU048_RS02100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CU048_RS02105	COG0255	Belongs to the universal ribosomal protein uL29 family
CU048_RS02110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CU048_RS02115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CU048_RS02120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CU048_RS02125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CU048_RS02130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CU048_RS02135	COG0089	rRNA binding
CU048_RS02140	COG0088	Forms part of the polypeptide exit tunnel
CU048_RS02145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CU048_RS02150	COG0051	transcription antitermination factor activity, RNA binding
CU048_RS02155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CU048_RS02160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CU048_RS02165	COG0049	tRNA binding
CU048_RS02170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CU048_RS02175	COG0753	catalase activity
CU048_RS02180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CU048_RS02185	COG0085	RNA polymerase activity
CU048_RS02190	COG0222	ribosome binding
CU048_RS02195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CU048_RS02200	COG0081	regulation of translation
CU048_RS02205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CU048_RS02215	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CU048_RS02225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CU048_RS02230	COG0511	ligase activity, forming carbon-carbon bonds
CU048_RS02270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU048_RS02275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU048_RS02310	COG0148	phosphopyruvate hydratase activity
CU048_RS02320	COG1090	epimerase
CU048_RS02325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CU048_RS02330	COG0504	CTP synthase activity
CU048_RS02340	COG0149	triose-phosphate isomerase activity
CU048_RS02350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CU048_RS02365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CU048_RS02370	COG0134	indole-3-glycerol-phosphate synthase activity
CU048_RS02375	COG0315	cyclic pyranopterin monophosphate synthase activity
CU048_RS02380	COG0303	'Molybdopterin
CU048_RS02390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CU048_RS02395	COG0412	Dienelactone hydrolase
CU048_RS02405	COG3186	Phenylalanine-4-hydroxylase
CU048_RS02410	COG1028	Short-chain dehydrogenase reductase Sdr
CU048_RS02415	COG1522	sequence-specific DNA binding
CU048_RS02430	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CU048_RS02440	COG0625	glutathione transferase activity
CU048_RS02445	COG1396	sequence-specific DNA binding
CU048_RS02455	COG0438	transferase activity, transferring glycosyl groups
CU048_RS02465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU048_RS02475	COG0672	)-iron permease
CU048_RS02480	COG0513	Belongs to the DEAD box helicase family
CU048_RS02485	COG0316	Belongs to the HesB IscA family
CU048_RS02495	COG0123	including yeast histone deacetylase and acetoin utilization protein
CU048_RS02515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU048_RS02545	COG0745	RESPONSE REGULATOR receiver
CU048_RS02560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CU048_RS02565	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CU048_RS02590	COG0776	regulation of translation
CU048_RS02595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU048_RS02600	COG0416	fatty acid biosynthetic process
CU048_RS02620	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CU048_RS02625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CU048_RS02635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CU048_RS02645	COG0438	transferase activity, transferring glycosyl groups
CU048_RS02665	COG3206	protein involved in exopolysaccharide biosynthesis
CU048_RS02665	COG0489	protein tyrosine kinase activity
CU048_RS02675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CU048_RS02680	COG0494	nUDIX hydrolase
CU048_RS02720	COG1960	acyl-CoA dehydrogenase activity
CU048_RS02725	COG0009	L-threonylcarbamoyladenylate synthase
CU048_RS02735	COG1573	uracil-dna glycosylase
CU048_RS02775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CU048_RS02780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CU048_RS02785	COG0740	serine-type endopeptidase activity
CU048_RS02790	COG0544	peptidyl-prolyl cis-trans isomerase activity
CU048_RS02820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CU048_RS02820	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CU048_RS02835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU048_RS02840	COG0629	single-stranded DNA binding
CU048_RS02845	COG4206	TonB-dependent receptor
CU048_RS02860	COG1850	ribulose-bisphosphate carboxylase activity
CU048_RS02865	COG0662	Cupin 2, conserved barrel domain protein
CU048_RS02870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CU048_RS02890	COG0322	excinuclease ABC activity
CU048_RS02895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CU048_RS02905	COG0314	molybdopterin synthase activity
CU048_RS02925	COG2132	Multicopper oxidase
CU048_RS02930	COG2239	Acts as a magnesium transporter
CU048_RS02945	COG0321	lipoyl(octanoyl) transferase activity
CU048_RS02950	COG1136	(ABC) transporter
CU048_RS02960	COG0442	prolyl-tRNA aminoacylation
CU048_RS03010	COG1309	transcriptional regulator
CU048_RS03045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CU048_RS03050	COG0459	protein refolding
CU048_RS03055	COG0776	regulation of translation
CU048_RS03065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CU048_RS03070	COG0124	histidyl-tRNA synthetase
CU048_RS03075	COG0124	histidyl-tRNA synthetase
CU048_RS03095	COG1215	transferase activity, transferring glycosyl groups
CU048_RS03100	COG0235	Class ii aldolase
CU048_RS03105	COG0800	Aldolase
CU048_RS03110	COG0129	dihydroxy-acid dehydratase activity
CU048_RS03115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CU048_RS03155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CU048_RS03160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CU048_RS03175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CU048_RS03185	COG1830	Aldolase
CU048_RS03200	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CU048_RS03220	COG2267	carboxylic ester hydrolase activity
CU048_RS03225	COG4771	TonB-dependent receptor
CU048_RS03245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CU048_RS03250	COG2971	BadF BadG BcrA BcrD
CU048_RS03255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CU048_RS03260	COG0583	DNA-binding transcription factor activity
CU048_RS03270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU048_RS03280	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CU048_RS03285	COG2031	fatty acid transporter
CU048_RS03305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU048_RS03315	COG0542	response to heat
CU048_RS03335	COG2890	protein-(glutamine-N5) methyltransferase activity
CU048_RS03340	COG0326	Molecular chaperone. Has ATPase activity
CU048_RS03350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CU048_RS03360	COG0006	proline dipeptidase activity
CU048_RS03370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU048_RS03375	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CU048_RS03380	COG5487	UPF0391 membrane protein
CU048_RS03385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CU048_RS03420	COG3218	ABC-type transport auxiliary lipoprotein component
CU048_RS03420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU048_RS03425	COG3218	ABC-type transport auxiliary lipoprotein component
CU048_RS03425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU048_RS03430	COG1127	ABC transporter
CU048_RS03435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU048_RS03445	COG2372	response to copper ion
CU048_RS03450	COG1276	copper resistance
CU048_RS03455	COG2372	response to copper ion
CU048_RS03480	COG4948	Mandelate Racemase Muconate Lactonizing
CU048_RS03495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU048_RS03505	COG4770	biotin carboxylase activity
CU048_RS03510	COG0305	Participates in initiation and elongation during chromosome replication
CU048_RS03525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CU048_RS03530	COG4221	oxidoreductase activity
CU048_RS03535	COG2963	transposase activity
CU048_RS03580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CU048_RS03605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU048_RS03620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU048_RS03630	COG0037	tRNA processing
CU048_RS03635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU048_RS03640	COG2885	chlorophyll binding
CU048_RS03645	COG0823	Involved in the tonB-independent uptake of proteins
CU048_RS03665	COG0824	Thioesterase
CU048_RS03670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CU048_RS03685	COG3237	CsbD-like
CU048_RS03695	COG1028	Short-chain dehydrogenase reductase Sdr
CU048_RS03700	COG0735	belongs to the Fur family
CU048_RS03705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CU048_RS03720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU048_RS03720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU048_RS03725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CU048_RS03730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CU048_RS03740	COG2989	Protein conserved in bacteria
CU048_RS03750	COG1278	Cold shock
CU048_RS03755	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CU048_RS03780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CU048_RS03825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU048_RS03830	COG0719	Fe-S assembly protein
CU048_RS03835	COG0396	ATPase activity
CU048_RS03840	COG0719	Fe-S assembly protein
CU048_RS03845	COG1104	cysteine desulfurase activity
CU048_RS03850	COG2945	thiolester hydrolase activity
CU048_RS03860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CU048_RS03870	COG0574	Belongs to the PEP-utilizing enzyme family
CU048_RS03870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU048_RS03890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CU048_RS03900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CU048_RS03905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CU048_RS03915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CU048_RS03920	COG0372	Belongs to the citrate synthase family
CU048_RS03930	COG0318	PFAM AMP-dependent synthetase and ligase
CU048_RS03935	COG0318	PFAM AMP-dependent synthetase and ligase
CU048_RS03950	COG1408	metallophosphoesterase
CU048_RS03965	COG0704	Plays a role in the regulation of phosphate uptake
CU048_RS03970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU048_RS03975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU048_RS03980	COG0022	dehydrogenase e1 component
CU048_RS03980	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU048_RS03985	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU048_RS03995	COG1881	PFAM PEBP family protein
CU048_RS04010	COG1994	Peptidase M50
CU048_RS04015	COG0574	Belongs to the PEP-utilizing enzyme family
CU048_RS04015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU048_RS04035	COG0701	Predicted permease
CU048_RS04055	COG1393	Belongs to the ArsC family
CU048_RS04135	COG0481	GTPase activity
CU048_RS04155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CU048_RS04190	COG1877	trehalose-phosphatase activity
CU048_RS04230	COG0308	aminopeptidase N
CU048_RS04235	COG4122	O-methyltransferase activity
CU048_RS04240	COG2205	protein histidine kinase activity
CU048_RS04240	COG2202	Pas domain
CU048_RS04245	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CU048_RS04250	COG3850	Histidine kinase
CU048_RS04250	COG0642	Histidine kinase
CU048_RS04255	COG0745	RESPONSE REGULATOR receiver
CU048_RS04260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU048_RS04275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU048_RS04380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU048_RS04395	COG1595	DNA-templated transcription, initiation
CU048_RS04540	COG1360	Flagellar Motor Protein
CU048_RS04555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU048_RS04560	COG1338	Plays a role in the flagellum-specific transport system
CU048_RS04570	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CU048_RS04580	COG1706	bacterial-type flagellum-dependent cell motility
CU048_RS04585	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CU048_RS04590	COG4786	Flagellar basal body rod
CU048_RS04595	COG1677	Flagellar hook-basal body complex protein FliE
CU048_RS04600	COG1558	bacterial-type flagellum-dependent cell motility
CU048_RS04605	COG1815	bacterial-type flagellum-dependent cell motility
CU048_RS04615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CU048_RS04620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU048_RS04625	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU048_RS04635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CU048_RS04645	COG4786	Flagellar basal body rod
CU048_RS04650	COG1157	protein secretion by the type III secretion system
CU048_RS04660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CU048_RS04665	COG0284	orotidine-5'-phosphate decarboxylase activity
CU048_RS04670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CU048_RS04675	COG0484	heat shock protein binding
CU048_RS04680	COG0443	Heat shock 70 kDa protein
CU048_RS04705	COG0483	inositol monophosphate 1-phosphatase activity
CU048_RS04715	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CU048_RS04720	COG0469	pyruvate kinase activity
CU048_RS04760	COG4536	flavin adenine dinucleotide binding
CU048_RS04765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CU048_RS04775	COG0438	transferase activity, transferring glycosyl groups
CU048_RS04785	COG0297	glycogen (starch) synthase activity
CU048_RS04795	COG4166	transmembrane transport
CU048_RS04800	COG4174	ABC transporter (Permease)
CU048_RS04805	COG4239	(ABC) transporter, permease
CU048_RS04810	COG4172	Belongs to the ABC transporter superfamily
CU048_RS04815	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CU048_RS04825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CU048_RS04850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CU048_RS04860	COG0589	response to stress
CU048_RS04880	COG3106	COG3106 Predicted ATPase
CU048_RS04885	COG3768	UPF0283 membrane protein
CU048_RS04905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CU048_RS04910	COG0440	acetolactate synthase activity
CU048_RS04915	COG0028	Belongs to the TPP enzyme family
CU048_RS04925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CU048_RS04930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CU048_RS04935	COG0590	tRNA wobble adenosine to inosine editing
CU048_RS04940	COG1187	pseudouridine synthase activity
CU048_RS04945	COG0742	ribosomal rna small subunit methyltransferase
CU048_RS04950	COG0151	Belongs to the GarS family
CU048_RS04955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CU048_RS04960	COG0612	Peptidase, M16
CU048_RS04965	COG0612	Peptidase, M16
CU048_RS04975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CU048_RS04980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CU048_RS05005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU048_RS05010	COG1862	Preprotein translocase
CU048_RS05025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU048_RS05045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU048_RS05050	COG0484	heat shock protein binding
CU048_RS05060	COG2010	Cytochrome c
CU048_RS05060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU048_RS05075	COG2226	methyltransferase
CU048_RS05090	COG2855	membrane
CU048_RS05095	COG0473	3-isopropylmalate dehydrogenase activity
CU048_RS05100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CU048_RS05105	COG4133	protoheme IX ABC transporter activity
CU048_RS05110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU048_RS05125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU048_RS05135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU048_RS05160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CU048_RS05165	COG0156	8-amino-7-oxononanoate synthase activity
CU048_RS05170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU048_RS05185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU048_RS05190	COG1960	acyl-CoA dehydrogenase activity
CU048_RS05205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU048_RS05215	COG0583	DNA-binding transcription factor activity
CU048_RS05220	COG0492	ferredoxin-NADP+ reductase activity
CU048_RS05230	COG0408	coproporphyrinogen oxidase activity
CU048_RS05240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CU048_RS05245	COG0723	plastoquinol--plastocyanin reductase activity
CU048_RS05250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CU048_RS05250	COG2857	Cytochrome c1
CU048_RS05255	COG2857	Cytochrome c1
CU048_RS05255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CU048_RS05270	COG0167	dihydroorotate dehydrogenase activity
CU048_RS05280	COG0183	Belongs to the thiolase family
CU048_RS05285	COG0588	phosphoglycerate mutase activity
CU048_RS05315	COG0601	transmembrane transport
CU048_RS05320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU048_RS05325	COG4172	Belongs to the ABC transporter superfamily
CU048_RS05330	COG1024	Enoyl-CoA hydratase
CU048_RS05330	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU048_RS05340	COG0564	pseudouridine synthase activity
CU048_RS05355	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CU048_RS05375	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CU048_RS05410	COG1024	Enoyl-CoA hydratase
CU048_RS05410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CU048_RS05435	COG1672	PFAM Archaeal ATPase
CU048_RS05435	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CU048_RS05450	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
CU048_RS05460	COG3278	Belongs to the heme-copper respiratory oxidase family
CU048_RS05475	COG2010	Cytochrome c
CU048_RS05490	COG2217	Heavy metal translocating P-type atpase
CU048_RS05505	COG0842	Transport permease protein
CU048_RS05510	COG1131	(ABC) transporter
CU048_RS05540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU048_RS05540	COG3218	ABC-type transport auxiliary lipoprotein component
CU048_RS05545	COG1127	ABC transporter
CU048_RS05610	COG0688	phosphatidylethanolamine metabolic process
CU048_RS05615	COG5265	(ABC) transporter
CU048_RS05630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU048_RS05640	COG0215	cysteine-tRNA ligase activity
CU048_RS05655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CU048_RS05675	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CU048_RS05685	COG3108	Peptidase M15
CU048_RS05700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CU048_RS05705	COG0457	Tetratricopeptide repeat
CU048_RS05710	COG0038	chloride channel
CU048_RS05715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CU048_RS05720	COG0193	aminoacyl-tRNA hydrolase activity
CU048_RS05725	COG0012	GTP binding
CU048_RS05730	COG0778	Nitroreductase
CU048_RS05735	COG2201	protein-glutamate methylesterase activity
CU048_RS05740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CU048_RS05745	COG0358	DNA primase activity
CU048_RS05750	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CU048_RS05755	COG1610	YqeY-like protein
CU048_RS05785	COG0505	Belongs to the CarA family
CU048_RS05790	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CU048_RS05795	COG0505	Belongs to the CarA family
CU048_RS05805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CU048_RS05815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CU048_RS05835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU048_RS05835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU048_RS05855	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CU048_RS05895	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CU048_RS05905	COG0318	PFAM AMP-dependent synthetase and ligase
CU048_RS05925	COG3220	belongs to the UPF0276 family
CU048_RS05950	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CU048_RS05965	COG0792	nuclease activity
CU048_RS05970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CU048_RS05985	COG0784	Response regulator, receiver
CU048_RS05990	COG2363	Small membrane protein
CU048_RS05995	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CU048_RS06005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU048_RS06035	COG1174	glycine betaine transport
CU048_RS06040	COG1125	glycine betaine transport
CU048_RS06045	COG1174	glycine betaine transport
CU048_RS06050	COG1732	Glycine betaine
CU048_RS06055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CU048_RS06065	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CU048_RS06070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CU048_RS06075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU048_RS06085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CU048_RS06090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CU048_RS06115	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CU048_RS06125	COG0753	catalase activity
CU048_RS06130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CU048_RS06135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CU048_RS06140	COG1185	polyribonucleotide nucleotidyltransferase activity
CU048_RS06155	COG1360	Flagellar Motor Protein
CU048_RS06175	COG0515	serine threonine protein kinase
CU048_RS06175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CU048_RS06180	COG0318	PFAM AMP-dependent synthetase and ligase
CU048_RS06200	COG0543	2 iron, 2 sulfur cluster binding
CU048_RS06205	COG2346	COG2346, Truncated hemoglobins
CU048_RS06210	COG1959	2 iron, 2 sulfur cluster binding
CU048_RS06215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CU048_RS06225	COG0335	large ribosomal subunit rRNA binding
CU048_RS06245	COG0438	transferase activity, transferring glycosyl groups
CU048_RS06250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CU048_RS06260	COG1051	belongs to the nudix hydrolase family
CU048_RS06265	COG0793	Belongs to the peptidase S41A family
CU048_RS06275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CU048_RS06280	COG0799	negative regulation of ribosome biogenesis
CU048_RS06285	COG0443	Heat shock 70 kDa protein
CU048_RS06290	COG0539	negative regulation of cytoplasmic translation
CU048_RS06295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CU048_RS06300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU048_RS06305	COG0746	molybdenum cofactor guanylyltransferase activity
CU048_RS06335	COG0196	riboflavin kinase activity
CU048_RS06340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU048_RS06400	COG1252	NADH dehydrogenase
CU048_RS06405	COG0463	Glycosyl transferase, family 2
CU048_RS06410	COG0656	L-ascorbic acid biosynthetic process
CU048_RS06415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU048_RS06420	COG0110	maltose O-acetyltransferase activity
CU048_RS06425	COG0297	glycogen (starch) synthase activity
CU048_RS06430	COG0560	Phosphoserine phosphatase
CU048_RS06435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CU048_RS06445	COG1984	allophanate hydrolase subunit 2
CU048_RS06455	COG0137	argininosuccinate synthase activity
CU048_RS06460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CU048_RS06465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CU048_RS06490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU048_RS06505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU048_RS06505	COG2080	2 iron, 2 sulfur cluster binding
CU048_RS06510	COG3224	Antibiotic biosynthesis monooxygenase
CU048_RS06555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU048_RS06575	COG2140	Oxalate decarboxylase
CU048_RS06585	COG1012	belongs to the aldehyde dehydrogenase family
CU048_RS06590	COG0366	Alpha amylase catalytic
CU048_RS06595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU048_RS06605	COG0751	glycine-tRNA ligase activity
CU048_RS06615	COG0752	glycyl-tRNA synthetase alpha subunit
CU048_RS06645	COG0142	geranyltranstransferase activity
CU048_RS06660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CU048_RS06695	COG4771	TonB-dependent receptor
CU048_RS06725	COG1758	RNA polymerase activity
CU048_RS06735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CU048_RS06740	COG0736	holo-[acyl-carrier-protein] synthase activity
CU048_RS06745	COG0681	Belongs to the peptidase S26 family
CU048_RS06750	COG0571	ribonuclease III activity
CU048_RS06755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CU048_RS06760	COG1561	YicC-like family, N-terminal region
CU048_RS06765	COG0194	GDP metabolic process
CU048_RS06775	COG0438	transferase activity, transferring glycosyl groups
CU048_RS06780	COG0242	peptide deformylase activity
CU048_RS06790	COG0101	tRNA pseudouridine synthase activity
CU048_RS06810	COG0540	Belongs to the ATCase OTCase family
CU048_RS06820	COG0783	Belongs to the Dps family
CU048_RS06825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU048_RS06830	COG0557	exoribonuclease II activity
CU048_RS06850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CU048_RS06860	COG1381	Involved in DNA repair and RecF pathway recombination
CU048_RS06875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU048_RS06880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CU048_RS06885	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CU048_RS06890	COG0750	zinc metalloprotease
CU048_RS06895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CU048_RS06905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CU048_RS06910	COG0233	cytoplasmic translational termination
CU048_RS06915	COG0528	UMP kinase activity
CU048_RS06930	COG4581	dead DEAH box helicase
CU048_RS06955	COG4303	Ethanolamine ammonia lyase large subunit
CU048_RS06960	COG4302	ethanolamine ammonia-lyase activity
CU048_RS06965	COG0667	Aldo Keto reductase
CU048_RS06980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CU048_RS06985	COG1214	PFAM Peptidase M22, glycoprotease
CU048_RS06995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU048_RS07000	COG1702	phosphate starvation-inducible protein PhoH
CU048_RS07005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CU048_RS07010	COG1253	flavin adenine dinucleotide binding
CU048_RS07020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CU048_RS07025	COG2197	response regulator
CU048_RS07030	COG3916	Acyl-homoserine-lactone synthase
CU048_RS07035	COG1396	sequence-specific DNA binding
CU048_RS07040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CU048_RS07045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CU048_RS07055	COG1215	transferase activity, transferring glycosyl groups
CU048_RS07085	COG0336	Belongs to the RNA methyltransferase TrmD family
CU048_RS07090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CU048_RS07100	COG0228	four-way junction DNA binding
CU048_RS07110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CU048_RS07115	COG1078	dGTPase activity
CU048_RS07130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CU048_RS07135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CU048_RS07145	COG1846	Transcriptional regulator
CU048_RS07150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CU048_RS07155	COG3158	transport of potassium into the cell
CU048_RS07165	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CU048_RS07170	COG4208	sulfate ABC transporter
CU048_RS07175	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CU048_RS07180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CU048_RS07190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU048_RS07215	COG4191	Histidine kinase
CU048_RS07235	COG0640	Transcriptional regulator
CU048_RS07285	COG0714	Associated with various cellular activities
CU048_RS07295	COG2010	Cytochrome c
CU048_RS07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU048_RS07305	COG4993	Dehydrogenase
CU048_RS07310	COG2197	response regulator
CU048_RS07335	COG5487	UPF0391 membrane protein
CU048_RS07345	COG4191	Histidine kinase
CU048_RS07350	COG0628	permease
CU048_RS07355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU048_RS07385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CU048_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
CU048_RS07415	COG3239	Fatty acid desaturase
CU048_RS07420	COG5001	Diguanylate cyclase
CU048_RS07420	COG3300	MHYT domain
CU048_RS07450	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CU048_RS07450	COG3608	succinylglutamate desuccinylase aspartoacylase
CU048_RS07460	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CU048_RS07470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CU048_RS07505	COG0714	Associated with various cellular activities
CU048_RS07525	COG0617	tRNA 3'-terminal CCA addition
CU048_RS07540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CU048_RS07560	COG0500	methyltransferase
CU048_RS07580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CU048_RS07590	COG1722	exodeoxyribonuclease VII activity
CU048_RS07600	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CU048_RS07605	COG0519	Catalyzes the synthesis of GMP from XMP
CU048_RS07615	COG0354	folic acid binding
CU048_RS07620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU048_RS07635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CU048_RS07640	COG3258	Cytochrome c
CU048_RS07650	COG3191	aminopeptidase activity
CU048_RS07670	COG0259	pyridoxamine-phosphate oxidase activity
CU048_RS07695	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CU048_RS07715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CU048_RS07730	COG0628	permease
CU048_RS07740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU048_RS07755	COG3030	protein affecting phage T7 exclusion by the F plasmid
CU048_RS07765	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CU048_RS07785	COG0066	3-isopropylmalate dehydratase activity
CU048_RS07795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CU048_RS07800	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CU048_RS07805	COG0535	radical SAM domain protein
CU048_RS07810	COG0535	radical SAM domain protein
CU048_RS07845	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CU048_RS07865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU048_RS07875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU048_RS07880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CU048_RS07900	COG0183	Belongs to the thiolase family
CU048_RS07905	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CU048_RS07915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU048_RS07920	COG2226	methyltransferase
CU048_RS07930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CU048_RS07940	COG0739	heme binding
CU048_RS07945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CU048_RS07950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CU048_RS07960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CU048_RS07965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CU048_RS07970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CU048_RS08005	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CU048_RS08010	COG1492	cobalamin metabolic process
CU048_RS08055	COG2099	Precorrin-6x reductase
CU048_RS08075	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CU048_RS08080	COG1797	cobyrinic acid a,c-diamide synthase activity
CU048_RS08145	COG0784	Response regulator, receiver
CU048_RS08155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CU048_RS08160	COG1518	maintenance of DNA repeat elements
CU048_RS08195	COG1309	transcriptional regulator
CU048_RS08215	COG2345	Transcriptional regulator
CU048_RS08220	COG3023	N-Acetylmuramoyl-L-alanine amidase
CU048_RS08245	COG0247	lactate metabolic process
CU048_RS08255	COG0450	alkyl hydroperoxide reductase
CU048_RS08260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU048_RS08285	COG0105	UTP biosynthetic process
CU048_RS08290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CU048_RS08295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CU048_RS08300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CU048_RS08305	COG0628	permease
CU048_RS08330	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CU048_RS08335	COG2894	cell division
CU048_RS08340	COG0850	regulation of cytokinetic process
CU048_RS08355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CU048_RS08360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CU048_RS08365	COG0045	succinate-CoA ligase (ADP-forming) activity
CU048_RS08375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CU048_RS08380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CU048_RS08385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CU048_RS08445	COG0488	(ABC) transporter
CU048_RS08460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CU048_RS08465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CU048_RS08470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CU048_RS08475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CU048_RS08480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CU048_RS08495	COG0495	leucyl-tRNA aminoacylation
CU048_RS08505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CU048_RS08520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU048_RS08535	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CU048_RS08540	COG0438	transferase activity, transferring glycosyl groups
CU048_RS08550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CU048_RS08555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU048_RS08580	COG1819	glycosyl
CU048_RS08630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU048_RS08635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU048_RS08645	COG4149	molybdate abc transporter
CU048_RS08650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CU048_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
CU048_RS08670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CU048_RS08675	COG0564	pseudouridine synthase activity
CU048_RS08680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CU048_RS08685	COG0217	transcriptional regulatory protein
CU048_RS08720	COG0392	lysyltransferase activity
CU048_RS08725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CU048_RS08740	COG4651	solute:proton antiporter activity
CU048_RS08740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CU048_RS08750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU048_RS08780	COG0300	oxidoreductase activity
CU048_RS08785	COG1215	transferase activity, transferring glycosyl groups
CU048_RS08830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU048_RS08840	COG0405	Gamma-glutamyltransferase
CU048_RS08845	COG0514	ATP-dependent DNA helicase (RecQ)
CU048_RS08875	COG1131	(ABC) transporter
CU048_RS08895	COG0181	hydroxymethylbilane synthase activity
CU048_RS08905	COG0632	four-way junction helicase activity
CU048_RS08910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CU048_RS08915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CU048_RS08920	COG0268	Binds directly to 16S ribosomal RNA
CU048_RS08940	COG2951	lytic endotransglycosylase activity
CU048_RS08960	COG0483	inositol monophosphate 1-phosphatase activity
CU048_RS08985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CU048_RS08995	COG0488	(ABC) transporter
CU048_RS09010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CU048_RS09015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CU048_RS09020	COG0202	RNA polymerase activity
CU048_RS09025	COG0203	ribosomal protein L17
CU048_RS09030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU048_RS09035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CU048_RS09040	COG0366	Alpha amylase catalytic
CU048_RS09065	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CU048_RS09075	COG0596	Alpha beta hydrolase
CU048_RS09085	COG0071	Belongs to the small heat shock protein (HSP20) family
CU048_RS09100	COG0067	glutamate synthase
CU048_RS09100	COG0070	glutamate synthase
CU048_RS09100	COG0069	glutamate synthase activity
CU048_RS09110	COG1376	ErfK ybiS ycfS ynhG family protein
CU048_RS09115	COG1376	ErfK ybiS ycfS ynhG family protein
CU048_RS09140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CU048_RS09145	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CU048_RS09150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CU048_RS09155	COG2308	Evidence 4 Homologs of previously reported genes of
CU048_RS09170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CU048_RS09175	COG1981	membrane
CU048_RS09180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CU048_RS09185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CU048_RS09190	COG0424	maF-like protein
CU048_RS09195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CU048_RS09200	COG0237	dephospho-CoA kinase activity
CU048_RS09205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CU048_RS09215	COG0247	lactate metabolic process
CU048_RS09230	COG1072	(Pantothenic acid kinase))
CU048_RS09235	COG0140	phosphoribosyl-ATP diphosphatase activity
CU048_RS09240	COG0107	imidazoleglycerol-phosphate synthase activity
CU048_RS09245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CU048_RS09250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CU048_RS09260	COG0131	Imidazoleglycerol-phosphate dehydratase
CU048_RS09265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CU048_RS09270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CU048_RS09275	COG0180	Tryptophanyl-tRNA synthetase
CU048_RS09305	COG1331	Highly conserved protein containing a thioredoxin domain
CU048_RS09310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CU048_RS09315	COG0445	tRNA wobble uridine modification
CU048_RS09320	COG0357	Ribosomal RNA small subunit methyltransferase G
CU048_RS09340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CU048_RS09355	COG1253	flavin adenine dinucleotide binding
CU048_RS09375	COG0653	protein targeting
CU048_RS09380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU048_RS09385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CU048_RS09405	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CU048_RS09410	COG1309	transcriptional regulator
CU048_RS09425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU048_RS09425	COG3453	Protein conserved in bacteria
CU048_RS09450	COG2204	response regulator
CU048_RS09455	COG2989	Protein conserved in bacteria
CU048_RS09460	COG1607	acyl-coa hydrolase
CU048_RS09465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU048_RS09470	COG1846	Transcriptional regulator
CU048_RS09475	COG0745	RESPONSE REGULATOR receiver
CU048_RS09480	COG2205	protein histidine kinase activity
CU048_RS09485	COG2169	Transcriptional regulator
CU048_RS09485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CU048_RS09495	COG2884	Cell division ATP-binding protein ftsE
CU048_RS09510	COG0737	Belongs to the 5'-nucleotidase family
CU048_RS09515	COG0351	phosphomethylpyrimidine kinase
CU048_RS09540	COG0803	Belongs to the bacterial solute-binding protein 9 family
CU048_RS09545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU048_RS09555	COG1999	signal sequence binding
CU048_RS09565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CU048_RS09565	COG1648	precorrin-2 dehydrogenase activity
CU048_RS09580	COG1217	gtp-binding protein TYPA
CU048_RS09600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CU048_RS09605	COG2226	methyltransferase
CU048_RS09610	COG0735	belongs to the Fur family
CU048_RS09625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU048_RS09630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CU048_RS09635	COG1388	LysM domain
CU048_RS09635	COG1376	ErfK ybiS ycfS ynhG family protein
CU048_RS09640	COG1695	Transcriptional regulator
CU048_RS09650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CU048_RS09655	COG0756	dUTP diphosphatase activity
CU048_RS09670	COG1329	Transcriptional regulator
CU048_RS09675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CU048_RS09685	COG0523	cobalamin synthesis protein
CU048_RS09690	COG1686	Belongs to the peptidase S11 family
CU048_RS09695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU048_RS09755	COG0126	phosphoglycerate kinase activity
CU048_RS09805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CU048_RS09810	COG1692	metallophosphoesterase
CU048_RS09825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CU048_RS09830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU048_RS09840	COG4974	Belongs to the 'phage' integrase family
CU048_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
CU048_RS09880	COG0072	phenylalanine-tRNA ligase activity
CU048_RS09880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU048_RS09890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CU048_RS09895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CU048_RS09900	COG0363	glucosamine-6-phosphate deaminase activity
CU048_RS09905	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CU048_RS09925	COG2255	four-way junction helicase activity
CU048_RS09935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CU048_RS09940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CU048_RS09945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CU048_RS09960	COG0779	Required for maturation of 30S ribosomal subunits
CU048_RS09975	COG2835	tetraacyldisaccharide 4'-kinase activity
CU048_RS09990	COG1946	Acyl-CoA thioesterase
CU048_RS09995	COG0347	Belongs to the P(II) protein family
CU048_RS10000	COG0004	ammonium transporteR
CU048_RS10005	COG0166	Belongs to the GPI family
CU048_RS10010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU048_RS10015	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU048_RS10015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU048_RS10025	COG2205	protein histidine kinase activity
CU048_RS10030	COG0745	RESPONSE REGULATOR receiver
CU048_RS10035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CU048_RS10040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CU048_RS10040	COG1793	dna ligase
CU048_RS10060	COG0513	Belongs to the DEAD box helicase family
CU048_RS10070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CU048_RS10075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CU048_RS10080	COG0248	Ppx GppA phosphatase
CU048_RS10085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CU048_RS10090	COG0686	Belongs to the AlaDH PNT family
CU048_RS10095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CU048_RS10125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CU048_RS10130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU048_RS10140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CU048_RS10155	COG0360	Binds together with S18 to 16S ribosomal RNA
CU048_RS10160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CU048_RS10170	COG0359	binds to the 23S rRNA
CU048_RS10195	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CU048_RS10205	COG0154	amidase activity
CU048_RS10210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CU048_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
CU048_RS10230	COG4689	acetoacetate decarboxylase
CU048_RS10240	COG2326	polyphosphate kinase activity
CU048_RS10245	COG1376	ErfK ybiS ycfS ynhG family protein
CU048_RS10255	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CU048_RS10260	COG1058	Belongs to the CinA family
CU048_RS10260	COG1546	Belongs to the CinA family
CU048_RS10265	COG1522	sequence-specific DNA binding
CU048_RS10270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU048_RS10295	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU048_RS10300	COG3260	NADH ubiquinone oxidoreductase 20
CU048_RS10305	COG0649	NAD binding
CU048_RS10310	COG0651	ATP synthesis coupled electron transport
CU048_RS10320	COG0650	Formate hydrogenlyase subunit 4
CU048_RS10325	COG0651	ATP synthesis coupled electron transport
CU048_RS10335	COG2862	Uncharacterized protein family, UPF0114
CU048_RS10340	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU048_RS10345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU048_RS10350	COG0842	Transport permease protein
CU048_RS10350	COG1129	ABC transporter
CU048_RS10355	COG0842	Transport permease protein
CU048_RS10370	COG0134	indole-3-glycerol-phosphate synthase activity
CU048_RS10390	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CU048_RS10400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CU048_RS10405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CU048_RS10425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CU048_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
CU048_RS10455	COG1595	DNA-templated transcription, initiation
CU048_RS10480	COG0583	DNA-binding transcription factor activity
CU048_RS10495	COG3383	formate dehydrogenase (NAD+) activity
CU048_RS10500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CU048_RS10515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU048_RS10530	COG4251	negative regulation of phosphorylation
CU048_RS10535	COG2201	protein-glutamate methylesterase activity
CU048_RS10540	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CU048_RS10555	COG0432	Pfam Uncharacterised protein family UPF0047
CU048_RS10575	COG3546	catalase activity
CU048_RS10585	COG0436	Aminotransferase
CU048_RS10615	COG0243	molybdopterin cofactor binding
CU048_RS10625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU048_RS10630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU048_RS10635	COG1116	anion transmembrane transporter activity
CU048_RS10640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU048_RS10645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU048_RS10650	COG1116	anion transmembrane transporter activity
CU048_RS10650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU048_RS10655	COG2201	protein-glutamate methylesterase activity
CU048_RS10660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CU048_RS10665	COG0594	ribonuclease P activity
CU048_RS10670	COG0706	membrane insertase activity
CU048_RS10680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CU048_RS10700	COG2171	N-acyltransferase activity
CU048_RS10720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU048_RS10725	COG0287	Prephenate dehydrogenase
CU048_RS10730	COG0616	signal peptide processing
CU048_RS10735	COG0776	regulation of translation
CU048_RS10745	COG0135	phosphoribosylanthranilate isomerase activity
CU048_RS10750	COG0133	tryptophan synthase activity
CU048_RS10770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CU048_RS10825	COG1215	transferase activity, transferring glycosyl groups
CU048_RS10845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU048_RS10860	COG1137	ATPase activity
CU048_RS10865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CU048_RS10870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CU048_RS10875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU048_RS10880	COG0825	malonyl-CoA metabolic process
CU048_RS10885	COG3034	peptidoglycan biosynthetic process
CU048_RS10895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CU048_RS10895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CU048_RS10900	COG0837	glucose binding
CU048_RS10910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU048_RS10915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU048_RS10960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CU048_RS10970	COG0288	reversible hydration of carbon dioxide
CU048_RS10985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CU048_RS10990	COG1278	Cold shock
CU048_RS11000	COG0482	sulfurtransferase activity
CU048_RS11010	COG2917	probably involved in intracellular septation
CU048_RS11015	COG0552	protein localization to endoplasmic reticulum
CU048_RS11020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CU048_RS11030	COG1132	(ABC) transporter
CU048_RS11035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU048_RS11040	COG1562	ergosterol biosynthetic process
CU048_RS11045	COG1562	ergosterol biosynthetic process
CU048_RS11050	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CU048_RS11055	COG1657	PFAM Prenyltransferase squalene oxidase
CU048_RS11065	COG0535	radical SAM domain protein
CU048_RS11070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CU048_RS11085	COG2264	protein methyltransferase activity
CU048_RS11095	COG0785	Cytochrome C biogenesis protein
CU048_RS11130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU048_RS11135	COG5425	PFAM Usg family protein
CU048_RS11140	COG2003	Belongs to the UPF0758 family
CU048_RS11150	COG0583	DNA-binding transcription factor activity
CU048_RS11155	COG0024	Methionine aminopeptidase
CU048_RS11175	COG0556	nucleotide-excision repair
CU048_RS11185	COG3387	PFAM Glycoside hydrolase 15-related
CU048_RS11215	COG0667	Aldo Keto reductase
CU048_RS11230	COG1295	ribonuclease BN
CU048_RS11250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CU048_RS11255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CU048_RS11260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CU048_RS11280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU048_RS11290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CU048_RS11300	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CU048_RS11320	COG1968	undecaprenyl-diphosphatase activity
CU048_RS11325	COG0114	fumarate hydratase activity
CU048_RS11340	COG0784	Response regulator, receiver
CU048_RS11360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CU048_RS11370	COG3685	Protein conserved in bacteria
CU048_RS11375	COG0501	Belongs to the peptidase M48B family
CU048_RS11380	COG2259	Doxx family
CU048_RS11395	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CU048_RS11405	COG0590	tRNA wobble adenosine to inosine editing
CU048_RS11435	COG0546	phosphoglycolate phosphatase activity
CU048_RS11450	COG0667	Aldo Keto reductase
CU048_RS11470	COG0583	DNA-binding transcription factor activity
CU048_RS11475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CU048_RS11565	COG3851	Histidine kinase
CU048_RS11570	COG2197	response regulator
CU048_RS11615	COG4774	siderophore transport
CU048_RS11625	COG0626	cystathionine gamma-synthase activity
CU048_RS11640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU048_RS11650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CU048_RS11660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CU048_RS11670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU048_RS11680	COG0450	alkyl hydroperoxide reductase
CU048_RS11695	COG3264	Mechanosensitive ion channel
CU048_RS11695	COG1196	nuclear chromosome segregation
CU048_RS11700	COG1509	lysine 2,3-aminomutase activity
CU048_RS11710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CU048_RS11775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU048_RS11785	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CU048_RS11905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CU048_RS11905	COG1024	Enoyl-CoA hydratase
CU048_RS11910	COG4977	sequence-specific DNA binding
CU048_RS11960	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CU048_RS11965	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CU048_RS11970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CU048_RS11975	COG2205	protein histidine kinase activity
CU048_RS12010	COG0175	sulfate reduction
CU048_RS12075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CU048_RS12090	COG3118	belongs to the thioredoxin family
CU048_RS12110	COG2151	metal-sulfur cluster biosynthetic enzyme
CU048_RS12115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU048_RS12120	COG0719	Fe-S assembly protein
CU048_RS12125	COG0396	ATPase activity
CU048_RS12130	COG0719	Fe-S assembly protein
CU048_RS12140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CU048_RS12140	COG3608	succinylglutamate desuccinylase aspartoacylase
CU048_RS12145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CU048_RS12150	COG3411	Ferredoxin
CU048_RS12155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU048_RS12175	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CU048_RS12185	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CU048_RS12190	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CU048_RS12195	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CU048_RS12210	COG5420	small protein containing a coiled-coil domain
CU048_RS12215	COG3383	formate dehydrogenase (NAD+) activity
CU048_RS12235	COG2897	thiosulfate sulfurtransferase activity
CU048_RS12245	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CU048_RS12245	COG1618	nucleotide phosphatase activity, acting on free nucleotides
CU048_RS12280	COG0316	Belongs to the HesB IscA family
CU048_RS12290	COG1104	cysteine desulfurase activity
CU048_RS12295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU048_RS12310	COG2086	electron transfer activity
CU048_RS12315	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CU048_RS12320	COG0644	oxidoreductase
CU048_RS12335	COG3604	Transcriptional regulator
CU048_RS12340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CU048_RS12345	COG5554	nitrogen fixation
CU048_RS12355	COG0535	radical SAM domain protein
CU048_RS12360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CU048_RS12380	COG5554	nitrogen fixation
CU048_RS12400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CU048_RS12440	COG1331	Highly conserved protein containing a thioredoxin domain
CU048_RS12445	COG2346	COG2346, Truncated hemoglobins
CU048_RS12470	COG0412	Dienelactone hydrolase
CU048_RS12475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CU048_RS12480	COG0758	DNA mediated transformation
CU048_RS12485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU048_RS12490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU048_RS12495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU048_RS12500	COG0649	NAD binding
CU048_RS12510	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CU048_RS12520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CU048_RS12525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU048_RS12535	COG0713	ATP synthesis coupled electron transport
CU048_RS12550	COG1007	ATP synthesis coupled electron transport
CU048_RS12565	COG0346	lactoylglutathione lyase activity
CU048_RS12610	COG2815	serine threonine protein kinase
CU048_RS12610	COG0515	serine threonine protein kinase
CU048_RS12615	COG0631	protein serine/threonine phosphatase activity
CU048_RS12620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU048_RS12625	COG0521	Mo-molybdopterin cofactor biosynthetic process
CU048_RS12630	COG2308	Evidence 4 Homologs of previously reported genes of
CU048_RS12630	COG2307	Protein conserved in bacteria
CU048_RS12650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CU048_RS12660	COG0339	signal peptide processing
CU048_RS12670	COG0189	ligase activity
CU048_RS12675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CU048_RS12680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CU048_RS12685	COG3047	cAMP biosynthetic process
CU048_RS12725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU048_RS12735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CU048_RS12740	COG0039	L-malate dehydrogenase activity
CU048_RS12745	COG0045	succinate-CoA ligase (ADP-forming) activity
CU048_RS12750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CU048_RS12825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CU048_RS12830	COG1902	pentaerythritol trinitrate reductase activity
CU048_RS12835	COG3750	Belongs to the UPF0335 family
CU048_RS12845	COG1982	Orn Lys Arg decarboxylase major
CU048_RS12860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU048_RS12865	COG0058	SHG alpha-glucan phosphorylase activity
CU048_RS12870	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CU048_RS12875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU048_RS12880	COG0297	glycogen (starch) synthase activity
CU048_RS12885	COG0033	Phosphoglucomutase
CU048_RS12895	COG3237	CsbD-like
CU048_RS12900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU048_RS12905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU048_RS12910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CU048_RS12940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU048_RS12945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CU048_RS12950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CU048_RS12965	COG0848	biopolymer transport protein
CU048_RS12990	COG0386	Belongs to the glutathione peroxidase family
CU048_RS12995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CU048_RS13000	COG5328	Belongs to the UPF0262 family
CU048_RS13005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CU048_RS13010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CU048_RS13040	COG2001	Belongs to the MraZ family
CU048_RS13045	COG0275	rRNA processing
CU048_RS13060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CU048_RS13070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CU048_RS13085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU048_RS13090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CU048_RS13095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CU048_RS13100	COG1181	Belongs to the D-alanine--D-alanine ligase family
CU048_RS13110	COG0849	cell division
CU048_RS13115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CU048_RS13140	COG2154	pterin-4-alpha-carbinolamine dehydratase
CU048_RS13155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CU048_RS13160	COG1335	isochorismatase
CU048_RS13170	COG3620	sequence-specific DNA binding
CU048_RS13170	COG0617	tRNA 3'-terminal CCA addition
CU048_RS13170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CU048_RS13175	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU048_RS13185	COG0302	gtp cyclohydrolase
CU048_RS13200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CU048_RS13205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU048_RS13215	COG4585	Histidine kinase
CU048_RS13250	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU048_RS13255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU048_RS13265	COG0688	phosphatidylethanolamine metabolic process
CU048_RS13330	COG4235	cytochrome complex assembly
CU048_RS13335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CU048_RS13340	COG1138	Cytochrome C-type biogenesis protein
CU048_RS13345	COG3088	subunit of a heme lyase
CU048_RS13360	COG2217	Heavy metal translocating P-type atpase
CU048_RS13365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CU048_RS13370	COG0393	Putative heavy-metal-binding
CU048_RS13380	COG2321	neutral zinc metallopeptidase
CU048_RS13385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CU048_RS13500	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CU048_RS13505	COG0300	oxidoreductase activity
CU048_RS13530	COG0671	phosphoesterase, PA-phosphatase related
CU048_RS13535	COG2326	polyphosphate kinase activity
CU048_RS13575	COG0028	Belongs to the TPP enzyme family
CU048_RS13580	COG3459	Glycosyltransferase 36 associated
CU048_RS13590	COG3033	Beta-eliminating lyase
CU048_RS13615	COG1845	cytochrome c oxidase, subunit III
CU048_RS13620	COG1845	cytochrome c oxidase, subunit III
CU048_RS13625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU048_RS13630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CU048_RS13635	COG0606	chelatase, subunit chli
CU048_RS13655	COG1472	Belongs to the glycosyl hydrolase 3 family
CU048_RS13660	COG1408	metallophosphoesterase
CU048_RS13670	COG0154	amidase activity
CU048_RS13685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU048_RS13695	COG0587	DNA-directed DNA polymerase activity
CU048_RS13745	COG0861	Integral membrane protein TerC family
CU048_RS13765	COG0175	sulfate reduction
CU048_RS13770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU048_RS13780	COG0586	Pfam SNARE associated Golgi protein
CU048_RS13785	COG2084	Dehydrogenase
CU048_RS13795	COG0489	protein tyrosine kinase activity
CU048_RS13815	COG0477	Major facilitator Superfamily
CU048_RS13900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU048_RS13940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU048_RS13960	COG0302	gtp cyclohydrolase
CU048_RS13965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU048_RS13970	COG0254	rRNA binding
CU048_RS13975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CU048_RS13990	COG5002	protein histidine kinase activity
CU048_RS13995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CU048_RS14000	COG0573	inorganic phosphate transmembrane transporter activity
CU048_RS14005	COG0581	inorganic phosphate transmembrane transporter activity
CU048_RS14010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CU048_RS14015	COG0704	Plays a role in the regulation of phosphate uptake
CU048_RS14020	COG0745	RESPONSE REGULATOR receiver
CU048_RS14045	COG3920	Histidine kinase
CU048_RS14050	COG1028	Short-chain dehydrogenase reductase Sdr
CU048_RS14060	COG0300	oxidoreductase activity
CU048_RS14065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU048_RS14070	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CU048_RS14115	COG3045	CreA protein
CU048_RS14120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CU048_RS14130	COG3243	poly(R)-hydroxyalkanoic acid synthase
CU048_RS14160	COG4191	Histidine kinase
CU048_RS14165	COG4566	intracellular signal transduction
CU048_RS14175	COG0071	Belongs to the small heat shock protein (HSP20) family
CU048_RS14190	COG0842	Transport permease protein
CU048_RS14195	COG0842	Transport permease protein
CU048_RS14195	COG1129	ABC transporter
CU048_RS14200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU048_RS14205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU048_RS14280	COG1278	Cold shock
CU048_RS14295	COG0564	pseudouridine synthase activity
CU048_RS14305	COG2124	cytochrome p450
CU048_RS14310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU048_RS14320	COG1254	Belongs to the acylphosphatase family
CU048_RS14325	COG2814	Major facilitator Superfamily
CU048_RS14330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CU048_RS14335	COG0281	malic enzyme
CU048_RS14335	COG0280	phosphate acetyltransferase
CU048_RS14345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU048_RS14380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CU048_RS14385	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CU048_RS14395	COG3206	protein involved in exopolysaccharide biosynthesis
CU048_RS14395	COG0489	protein tyrosine kinase activity
CU048_RS14405	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CU048_RS14415	COG2271	Major facilitator Superfamily
CU048_RS14420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CU048_RS14430	COG1570	exodeoxyribonuclease VII activity
CU048_RS14450	COG0425	Belongs to the sulfur carrier protein TusA family
CU048_RS14455	COG1763	Mo-molybdopterin cofactor biosynthetic process
CU048_RS14460	COG0303	'Molybdopterin
CU048_RS14465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CU048_RS14470	COG1993	acr, cog1993
CU048_RS14475	COG2223	nitrite transmembrane transporter activity
CU048_RS14490	COG0626	cystathionine gamma-synthase activity
CU048_RS14495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU048_RS14525	COG0277	FAD linked oxidase domain protein
CU048_RS14540	COG0052	Belongs to the universal ribosomal protein uS2 family
CU048_RS14545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CU048_RS14565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CU048_RS14580	COG0525	valine-tRNA ligase activity
CU048_RS14585	COG1914	H( )-stimulated, divalent metal cation uptake system
CU048_RS14590	COG1321	iron dependent repressor
CU048_RS14595	COG0129	dihydroxy-acid dehydratase activity
CU048_RS14600	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CU048_RS14610	COG0708	Exodeoxyribonuclease III
CU048_RS14615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU048_RS14640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU048_RS14650	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CU048_RS14655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CU048_RS14680	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CU048_RS14710	COG0138	bifunctional purine biosynthesis protein purh
CU048_RS14735	COG1872	DUF167
CU048_RS14765	COG0306	phosphate transporter
CU048_RS14770	COG2202	Pas domain
CU048_RS14770	COG3920	Histidine kinase
CU048_RS14775	COG0667	Aldo Keto reductase
CU048_RS14780	COG0583	DNA-binding transcription factor activity
CU048_RS14790	COG2271	Major facilitator Superfamily
CU048_RS14800	COG0667	Aldo Keto reductase
CU048_RS14825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CU048_RS14830	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU048_RS14835	COG1530	ribonuclease E activity
CU048_RS14835	COG1530	ribonuclease E activity
CU048_RS14845	COG0436	Aminotransferase
CU048_RS14875	COG1116	anion transmembrane transporter activity
CU048_RS14880	COG4176	ABC-type proline glycine betaine transport system permease component
CU048_RS14895	COG0579	oxidoreductase
CU048_RS14905	COG0156	8-amino-7-oxononanoate synthase activity
CU048_RS14920	COG3243	poly(R)-hydroxyalkanoic acid synthase
CU048_RS14925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CU048_RS14930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CU048_RS14935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CU048_RS14940	COG1832	CoA-binding protein
CU048_RS14945	COG1612	heme a metabolic process
CU048_RS14965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CU048_RS14980	COG2202	Pas domain
CU048_RS14980	COG2205	protein histidine kinase activity
CU048_RS14985	COG0784	Response regulator, receiver
CU048_RS15025	COG0628	permease
CU048_RS15060	COG0492	ferredoxin-NADP+ reductase activity
CU048_RS15070	COG2134	cdp-diacylglycerol pyrophosphatase
CU048_RS15100	COG1321	iron dependent repressor
CU048_RS15115	COG2217	Heavy metal translocating P-type atpase
CU048_RS15145	COG2226	methyltransferase
CU048_RS15160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CU048_RS15170	COG1238	metal cluster binding
CU048_RS15175	COG3161	chorismate lyase activity
CU048_RS15180	COG1040	competence protein
CU048_RS15215	COG1091	dTDP-4-dehydrorhamnose reductase activity
CU048_RS15225	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CU048_RS15240	COG1215	transferase activity, transferring glycosyl groups
CU048_RS15260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CU048_RS15270	COG4181	ATPase activity
CU048_RS15275	COG0113	porphobilinogen synthase activity
CU048_RS15290	COG0187	DNA topoisomerase II activity
CU048_RS15300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU048_RS15305	COG0174	glutamine synthetase
CU048_RS15310	COG0347	Belongs to the P(II) protein family
CU048_RS15320	COG2897	thiosulfate sulfurtransferase activity
CU048_RS15335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU048_RS15350	COG4957	zinc ion binding
CU048_RS15355	COG2166	iron-sulfur cluster assembly
CU048_RS15365	COG2205	protein histidine kinase activity
CU048_RS15380	COG0433	COG0433 Predicted ATPase
CU048_RS15405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CU048_RS15410	COG2983	Belongs to the UPF0260 family
CU048_RS15420	COG1215	transferase activity, transferring glycosyl groups
CU048_RS15455	COG1024	Enoyl-CoA hydratase