locus-tag	class	description
HF888_RS00010	ENOG4105C4R	Atp-dependent dna helicase
HF888_RS00015	ENOG41082J7	Rhodanese domain protein
HF888_RS00020	ENOG4105D3R	alkyl hydroperoxide reductase
HF888_RS00025	ENOG4105GAV	receptor
HF888_RS00045	ENOG4105D0M	Protease HtpX homolog
HF888_RS00060	ENOG4108Z33	Thiol disulfide Interchange Protein
HF888_RS00065	ENOG4106RE7	Cytochrome
HF888_RS00070	ENOG4105MPD	Cytochrome
HF888_RS00075	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HF888_RS00090	ENOG4105C2M	dna polymerase I
HF888_RS00100	ENOG4105CUV	Homoserine Kinase
HF888_RS00105	ENOG41067HS	methyltransferase
HF888_RS00110	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HF888_RS00115	ENOG4105NXV	High-affinity zinc uptake system protein
HF888_RS00120	ENOG4105FDK	ABC transporter
HF888_RS00125	ENOG4105FAV	ABC, transporter
HF888_RS00135	ENOG4107R73	Mate efflux family protein
HF888_RS00150	ENOG4108Z0R	Transferase
HF888_RS00155	ENOG4105DGW	oligopeptidase A
HF888_RS00175	ENOG4105M3Z	response regulator
HF888_RS00180	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HF888_RS00185	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HF888_RS00200	ENOG4105DIJ	Phosphoethanolamine transferase
HF888_RS00205	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HF888_RS00210	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HF888_RS00215	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HF888_RS00220	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HF888_RS00225	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF888_RS00230	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF888_RS00240	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HF888_RS00245	ENOG41064MJ	ATP synthase, subunit I
HF888_RS00250	ENOG4105FA0	parb-like partition protein
HF888_RS00255	ENOG4107QJE	Chromosome Partitioning Protein
HF888_RS00265	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HF888_RS00275	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HF888_RS00280	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HF888_RS00285	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HF888_RS00290	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HF888_RS00295	ENOG4105VG0	50S ribosomal protein l34
HF888_RS00300	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HF888_RS00305	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HF888_RS00310	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HF888_RS00315	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF888_RS00325	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HF888_RS00330	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HF888_RS00335	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HF888_RS00345	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HF888_RS00350	ENOG4105D1S	lipid A biosynthesis
HF888_RS00355	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HF888_RS00360	ENOG4105C1A	potassium transporter peripheral membrane
HF888_RS00370	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HF888_RS00375	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HF888_RS00385	ENOG4105C79	DNA protecting protein DprA
HF888_RS00390	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF888_RS00395	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HF888_RS00400	ENOG4105E2X	shikimate dehydrogenase
HF888_RS00410	ENOG4106KNT	transcriptional regulator
HF888_RS00415	ENOG4105C4R	Atp-dependent dna helicase
HF888_RS00425	ENOG4105CH5	extracellular solute-binding protein, family 7
HF888_RS00445	ENOG4105NAU	thioesterase Superfamily protein
HF888_RS00450	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HF888_RS00460	ENOG4105DJH	phosphate
HF888_RS00465	ENOG4105C8U	phosphate abc transporter
HF888_RS00470	ENOG4105C8U	phosphate abc transporter
HF888_RS00475	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HF888_RS00480	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HF888_RS00510	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HF888_RS00515	ENOG4108VYJ	response regulator receiver protein
HF888_RS00520	ENOG4105BZU	Histidine kinase
HF888_RS00525	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HF888_RS00530	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HF888_RS00540	ENOG4105ECQ	AraC Family Transcriptional Regulator
HF888_RS00555	ENOG4107QZF	nitrite reductase NADPH large subunit
HF888_RS00560	ENOG4105NYX	DNA-binding protein
HF888_RS00570	ENOG4105CK2	sodium dicarboxylate symporter
HF888_RS00590	ENOG4105CB5	ATP-dependent DNA helicase recG
HF888_RS00595	ENOG4105C5Q	Transcriptional regulator
HF888_RS00605	ENOG4105CJP	fad dependent oxidoreductase
HF888_RS00615	ENOG4105VNT	transposase (IS4 family) protein
HF888_RS00625	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HF888_RS00630	ENOG4105W0E	50S ribosomal protein L33
HF888_RS00635	ENOG4105KDC	50s ribosomal protein l28
HF888_RS00640	ENOG4107T0K	Adenylate cyclase
HF888_RS00650	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HF888_RS00655	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HF888_RS00670	ENOG4105NTD	Inherit from COG: Hydrolase
HF888_RS00680	ENOG4105BZU	Histidine kinase
HF888_RS00685	ENOG4107S90	membrAne
HF888_RS00695	ENOG4105M08	Membrane
HF888_RS00700	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HF888_RS00710	ENOG4105CSA	Coproporphyrinogen iii oxidase
HF888_RS00715	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HF888_RS00725	ENOG4105DWV	Homoserine O-trans-acetylase
HF888_RS00730	ENOG4105DWV	Homoserine O-trans-acetylase
HF888_RS00735	ENOG4108VIA	integral membrane protein
HF888_RS00740	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HF888_RS00745	ENOG4105DSJ	YicC domain protein
HF888_RS00750	ENOG4105BZU	Histidine kinase
HF888_RS00755	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HF888_RS00760	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HF888_RS00765	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HF888_RS00770	ENOG4105KME	endoribonuclease L-psp
HF888_RS00775	ENOG4105CH7	arginosuccinase
HF888_RS00780	ENOG4108HRK	Histidine kinase
HF888_RS00785	ENOG4108NEV	two component transcriptional regulator, LytTR family
HF888_RS00790	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HF888_RS00795	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HF888_RS00820	ENOG4105BZU	Histidine kinase
HF888_RS00825	ENOG4105CEN	a g-specific adenine glycosylase
HF888_RS00830	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HF888_RS00865	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF888_RS00870	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HF888_RS00875	ENOG4105CAK	Cell division ATP-binding protein ftsE
HF888_RS00880	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HF888_RS00890	ENOG4106H78	methyltransferase
HF888_RS00900	ENOG41062JF	Transcriptional regulator
HF888_RS00905	ENOG4107RGH	Aldehyde dehydrogenase
HF888_RS00920	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HF888_RS00925	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HF888_RS00935	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HF888_RS00950	ENOG4105CYW	agmatinase
HF888_RS00965	ENOG4107RZC	phospholipase d
HF888_RS00975	ENOG4105BZU	Histidine kinase
HF888_RS00985	ENOG4105BZU	Histidine kinase
HF888_RS01020	ENOG4105DWT	malate dehydrogenase (quinone)
HF888_RS01025	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HF888_RS01030	ENOG4105W8H	transhydrogenase (subunit alpha
HF888_RS01035	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HF888_RS01080	ENOG4105EMN	RNA polymerase sigma factor
HF888_RS01170	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HF888_RS01175	ENOG4105MPD	Cytochrome
HF888_RS01185	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HF888_RS01190	ENOG4105CAS	nag kinase
HF888_RS01195	ENOG4107QKV	phosphomannomutase
HF888_RS01200	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HF888_RS01210	ENOG4105W5Q	DNA repair protein (RadC
HF888_RS01225	ENOG4105II7	pyrroline-5-carboxylate reductase
HF888_RS01230	ENOG4105DFA	alanine racemase domain protein
HF888_RS01235	ENOG4105CZX	twitching motility protein
HF888_RS01240	ENOG4105CZX	twitching motility protein
HF888_RS01250	ENOG4108IXY	short-chain dehydrogenase reductase
HF888_RS01255	ENOG4107QK7	reductase
HF888_RS01260	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HF888_RS01265	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HF888_RS01270	ENOG4105K63	Thioredoxin
HF888_RS01275	ENOG4105C9X	ppx gppa phosphatase
HF888_RS01280	ENOG4105PXI	polysaccharide deacetylase
HF888_RS01285	ENOG4105CN1	protease
HF888_RS01290	ENOG41063SB	peptidase
HF888_RS01295	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HF888_RS01300	ENOG4107YZP	Rhodanese domain protein
HF888_RS01305	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HF888_RS01315	ENOG4105DR4	Methyltransferase
HF888_RS01330	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HF888_RS01335	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HF888_RS01345	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HF888_RS01355	ENOG4105SYT	Methylenetetrahydrofolate reductase
HF888_RS01360	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HF888_RS01365	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HF888_RS01370	ENOG41085FC	arsR family transcriptional regulator
HF888_RS01380	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HF888_RS01385	ENOG4107RK2	ADP-ribose diphosphatase NudE
HF888_RS01390	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
HF888_RS01395	ENOG4105VEJ	Heat shock protein
HF888_RS01405	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HF888_RS01410	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HF888_RS01415	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
HF888_RS01425	ENOG4105HF0	Membrane
HF888_RS01435	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HF888_RS01445	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HF888_RS01455	ENOG41080TK	Universal stress protein
HF888_RS01460	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HF888_RS01465	ENOG4108K1J	Transporter DctQ
HF888_RS01470	ENOG4108KJ1	Trap dicarboxylate transporter, dctp subunit
HF888_RS01480	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HF888_RS01485	ENOG41080XQ	Signal transduction protein with cbs domains
HF888_RS01490	ENOG4105CH2	amidohydrolase
HF888_RS01495	ENOG4108JPW	Aminotransferase
HF888_RS01515	ENOG4105C2C	drug resistance transporter, Bcr CflA
HF888_RS01530	ENOG4107ENK	receptor
HF888_RS01535	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HF888_RS01540	ENOG4105D56	permease protein
HF888_RS01560	ENOG4105EAC	phosphoserine phosphatase
HF888_RS01565	ENOG4105BZU	Histidine kinase
HF888_RS01570	ENOG4105C25	Primosomal protein n'
HF888_RS01575	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HF888_RS01580	ENOG4105C6K	Malic enzyme
HF888_RS01585	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HF888_RS01610	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HF888_RS01615	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HF888_RS01620	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HF888_RS01625	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HF888_RS01630	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF888_RS01635	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HF888_RS01640	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HF888_RS01645	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HF888_RS01650	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HF888_RS01655	ENOG41083MP	50s ribosomal protein l29
HF888_RS01660	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HF888_RS01665	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HF888_RS01670	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HF888_RS01675	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HF888_RS01680	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HF888_RS01685	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HF888_RS01690	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HF888_RS01695	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HF888_RS01700	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HF888_RS01705	ENOG4105VPB	50S ribosomal protein L30
HF888_RS01710	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HF888_RS01715	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HF888_RS01720	ENOG41067V7	50S ribosomal protein L36
HF888_RS01725	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF888_RS01730	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HF888_RS01735	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HF888_RS01740	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF888_RS01745	ENOG4108ZT0	50S ribosomal protein l17
HF888_RS01750	ENOG4105CHU	acetyl-coa acetyltransferase
HF888_RS01760	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HF888_RS01765	ENOG4105UT3	Methyl-accepting chemotaxis
HF888_RS01770	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HF888_RS01775	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HF888_RS01780	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HF888_RS01785	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HF888_RS01790	ENOG4105DJ0	Poly(A) Polymerase
HF888_RS01795	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HF888_RS01800	ENOG4105BZU	Histidine kinase
HF888_RS01805	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HF888_RS01810	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HF888_RS01815	ENOG4105CHM	Aminotransferase
HF888_RS01820	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HF888_RS01835	ENOG4105C1J	atp-dependent rna helicase
HF888_RS01855	ENOG4105ETT	transcriptional Regulator, LysR family
HF888_RS01870	ENOG4105CHH	sulfate transporter
HF888_RS01875	ENOG4105CHU	acetyl-coa acetyltransferase
HF888_RS01890	ENOG4105D25	secreted protein
HF888_RS01895	ENOG4105WH1	Two component transcriptional regulator luxr family
HF888_RS01910	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HF888_RS01940	ENOG4108IAB	Phoh family
HF888_RS01950	ENOG4105C3M	thioredoxin reductase
HF888_RS01955	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HF888_RS01965	ENOG4105CQ2	DNA polymerase
HF888_RS01970	ENOG4105BZU	Histidine kinase
HF888_RS01990	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HF888_RS01995	ENOG4107QSA	Oxaloacetate decarboxylase
HF888_RS02015	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HF888_RS02020	ENOG4108YXA	Membrane
HF888_RS02030	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HF888_RS02045	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HF888_RS02050	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HF888_RS02055	ENOG4105DR5	peptidase
HF888_RS02060	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HF888_RS02095	ENOG4105DVT	helicase
HF888_RS02100	ENOG4105C2X	Arabinose 5-phosphate isomerase
HF888_RS02110	ENOG4107QN1	sodium solute
HF888_RS02125	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HF888_RS02135	ENOG4105BZU	Histidine kinase
HF888_RS02150	ENOG4105CPQ	Dehydrogenase
HF888_RS02175	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HF888_RS02185	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HF888_RS02200	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF888_RS02205	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HF888_RS02210	ENOG4105KTH	gatB Yqey
HF888_RS02215	ENOG4105VCC	30S ribosomal protein S21
HF888_RS02220	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF888_RS02225	ENOG4107ZVW	dihydroneopterin aldolase
HF888_RS02230	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HF888_RS02235	ENOG4105CHR	reductase
HF888_RS02240	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HF888_RS02265	ENOG4105ED1	spovr family
HF888_RS02270	ENOG4106AKX	UPF0229 protein
HF888_RS02275	ENOG4105CYN	Serine protein kinase
HF888_RS02280	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HF888_RS02285	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HF888_RS02295	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HF888_RS02300	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HF888_RS02305	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HF888_RS02310	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HF888_RS02315	ENOG4105EHM	Aminoglycoside phosphotransferase
HF888_RS02320	ENOG4108S0S	Nucleotidyl transferase
HF888_RS02325	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HF888_RS02330	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HF888_RS02335	ENOG4105DJV	ribulose-phosphate 3-epimerase
HF888_RS02340	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HF888_RS02345	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF888_RS02350	ENOG4105CSU	acyl-Coa dehydrogenase
HF888_RS02380	ENOG4105CBX	hi0933 family
HF888_RS02435	ENOG4105DUM	transcriptional regulator, lysR family
HF888_RS02440	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HF888_RS02445	ENOG4105DP0	ferredoxin-NADP reductase
HF888_RS02455	ENOG4105BZU	Histidine kinase
HF888_RS02460	ENOG4105BZU	Histidine kinase
HF888_RS02470	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HF888_RS02480	ENOG4105D9P	serine threonine protein kinase
HF888_RS02485	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
HF888_RS02490	ENOG4105TMB	Formate nitrite transporter
HF888_RS02495	ENOG4105C3G	gtp-binding protein
HF888_RS02500	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HF888_RS02505	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HF888_RS02510	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HF888_RS02520	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HF888_RS02525	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HF888_RS02530	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
HF888_RS02535	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HF888_RS02540	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HF888_RS02545	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HF888_RS02570	ENOG4105CRQ	synthase (Component I)
HF888_RS02580	ENOG4105DDQ	anthranilate synthase
HF888_RS02585	ENOG4107QYG	anthranilate phosphoribosyltransferase
HF888_RS02590	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HF888_RS02595	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HF888_RS02600	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HF888_RS02605	ENOG4108UKZ	OsmC family
HF888_RS02615	ENOG4105BZU	Histidine kinase
HF888_RS02620	ENOG4105C12	Phosphoribosylglycinamide synthetase
HF888_RS02625	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HF888_RS02630	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HF888_RS02635	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HF888_RS02645	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HF888_RS02650	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HF888_RS02685	ENOG4105I08	Pseudouridine synthase
HF888_RS02695	ENOG4105WKW	Pfam:DUF1458
HF888_RS02720	ENOG4105C1G	acyl-Coa dehydrogenase
HF888_RS02725	ENOG4108ZX5	transcriptional regulator
HF888_RS02735	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HF888_RS02740	ENOG4108UPT	UPF0178 protein
HF888_RS02765	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HF888_RS02770	ENOG4105CHU	acetyl-coa acetyltransferase
HF888_RS02795	ENOG4105EMY	transcriptional regulator
HF888_RS02800	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HF888_RS02805	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HF888_RS02845	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HF888_RS02865	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HF888_RS02870	ENOG4108UYB	regulatoR
HF888_RS02885	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HF888_RS02895	ENOG4105T95	Thiol disulfide interChange protein
HF888_RS02900	ENOG4105D6E	homoserine dehydrogenase
HF888_RS02905	ENOG4105D98	threonine synthase
HF888_RS02910	ENOG410804D	Sensor Signal Transduction Histidine Kinase
HF888_RS02925	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HF888_RS02930	ENOG4105D7T	ABC transporter
HF888_RS02935	ENOG4105DG7	nitrate ABC transporter
HF888_RS02945	ENOG4105F0N	pyrophosphate phospho-hydrolase
HF888_RS02955	ENOG4108IFG	nitrite reductase, (NAD(P)H)
HF888_RS02960	ENOG4105WZK	nitrite reductase NADPH small subunit
HF888_RS02965	ENOG4107QZF	nitrite reductase NADPH large subunit
HF888_RS02980	ENOG4107R3J	Transporter
HF888_RS02985	ENOG4105D9P	serine threonine protein kinase
HF888_RS03005	ENOG4105DFU	Cell wall formation (By similarity)
HF888_RS03010	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HF888_RS03030	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HF888_RS03035	ENOG4105C3J	Cysteine desulfurase
HF888_RS03045	ENOG4105C3K	feS assembly ATPase SufC
HF888_RS03055	ENOG4105C9B	Cysteine desulfurase
HF888_RS03070	ENOG4105CEY	Amp-dependent synthetase and ligase
HF888_RS03075	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HF888_RS03080	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HF888_RS03085	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HF888_RS03100	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HF888_RS03105	ENOG4105CUT	histidyl-tRNA synthetase
HF888_RS03110	ENOG4105N21	Membrane
HF888_RS03115	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HF888_RS03120	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HF888_RS03145	ENOG4105BZU	Histidine kinase
HF888_RS03155	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS03165	ENOG4108DG9	Smr protein MutS2
HF888_RS03170	ENOG41063SB	peptidase
HF888_RS03175	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HF888_RS03190	ENOG4108EUD	Lysophospholipase
HF888_RS03195	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HF888_RS03200	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HF888_RS03210	ENOG4108Z6B	deaminase
HF888_RS03215	ENOG4107USA	Thioredoxin
HF888_RS03230	ENOG4108Z4U	Ferredoxin
HF888_RS03235	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HF888_RS03240	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HF888_RS03250	ENOG4105QNF	Outer membrane lipoprotein
HF888_RS03255	ENOG4105BZU	Histidine kinase
HF888_RS03270	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HF888_RS03285	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HF888_RS03290	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HF888_RS03300	ENOG4105DHZ	alpha beta
HF888_RS03305	ENOG4105D6Z	AFG1 family ATPase
HF888_RS03310	ENOG4108KF1	Membrane
HF888_RS03325	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HF888_RS03330	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HF888_RS03340	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HF888_RS03345	ENOG4105CJN	penicillin-binding protein
HF888_RS03350	ENOG4105CNI	cell division protein FtsW
HF888_RS03355	ENOG4105CVE	Lytic murein transglycosylase
HF888_RS03360	ENOG4105K6T	rare lipoprotein A
HF888_RS03365	ENOG4105DZ1	carboxypeptidase
HF888_RS03385	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HF888_RS03405	ENOG4107V1M	polysaccharide export protein
HF888_RS03415	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HF888_RS03420	ENOG4108IJ1	Dehydrogenase
HF888_RS03450	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HF888_RS03455	ENOG4105E12	capsule polysaccharide
HF888_RS03460	ENOG41084CK	capsule polysaccharide
HF888_RS03470	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HF888_RS03475	ENOG4105CJR	Integral membrane protein (MviN
HF888_RS03480	ENOG4105DTN	riboflavin biosynthesis protein ribF
HF888_RS03485	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HF888_RS03490	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HF888_RS03495	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HF888_RS03505	ENOG4105EWT	decarboxylase family
HF888_RS03545	ENOG4105K5B	UPF0225 protein
HF888_RS03555	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HF888_RS03575	ENOG4107TH8	cina domain protein
HF888_RS03580	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HF888_RS03585	ENOG4105Y3E	Modulates RecA activity (By similarity)
HF888_RS03600	ENOG4107QN2	dihydrolipoyl dehydrogenase
HF888_RS03610	ENOG4105ZAI	
HF888_RS03620	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HF888_RS03625	ENOG4105D6J	arsenicaL-resistance protein
HF888_RS03630	ENOG41082YX	Transcriptional regulator, arsr family
HF888_RS03635	ENOG4108WQI	RNA Polymerase
HF888_RS03660	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HF888_RS03665	ENOG4105CSU	acyl-Coa dehydrogenase
HF888_RS03670	ENOG4105CSU	acyl-Coa dehydrogenase
HF888_RS03680	ENOG4105KJM	monovalent cation h antiporter subunit g
HF888_RS03685	ENOG4105W4C	monovalent cation H antiporter subunit F
HF888_RS03690	ENOG4105SC1	monovalent cation H antiporter subunit E
HF888_RS03695	ENOG4107R4Z	monovalent cation h antiporter subunit d
HF888_RS03700	ENOG4108ZE9	Monovalent cation H antiporter subunit C
HF888_RS03705	ENOG4105D65	subunit l
HF888_RS03710	ENOG4107UI5	Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity)
HF888_RS03715	ENOG4105C2W	permease
HF888_RS03720	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HF888_RS03725	ENOG4105D05	Receptor
HF888_RS03740	ENOG4105NF4	modulator of drug activity
HF888_RS03745	ENOG4105CF7	AraC family transcriptional regulator
HF888_RS03750	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HF888_RS03755	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HF888_RS03760	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HF888_RS03770	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HF888_RS03780	ENOG4108Z03	MAF-like protein
HF888_RS03785	ENOG4105C03	ribonuclease
HF888_RS03805	ENOG4105CJW	magnesium transporter
HF888_RS03810	ENOG41080Z8	PHOSPHOCARRIER protein
HF888_RS03815	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HF888_RS03820	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HF888_RS03825	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HF888_RS03830	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF888_RS03835	ENOG4108IUZ	ABC transporter
HF888_RS03840	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HF888_RS03850	ENOG4105C2X	Arabinose 5-phosphate isomerase
HF888_RS03860	ENOG4105VFK	BolA family
HF888_RS03865	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HF888_RS03870	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HF888_RS03875	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HF888_RS03880	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HF888_RS03885	ENOG4105C0H	protease
HF888_RS03890	ENOG4107QNR	UPF0135 protein
HF888_RS03900	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HF888_RS03995	ENOG4105DGU	Histone deacetylase
HF888_RS04015	ENOG4105DKB	L-sorbosone dehydrogenase
HF888_RS04020	ENOG4105CGY	Dna recombination protein
HF888_RS04030	ENOG4108ZAF	Molybdopterin
HF888_RS04035	ENOG4105M00	molybdopterin converting factor, subunit 1
HF888_RS04040	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HF888_RS04045	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HF888_RS04050	ENOG4107IFA	Lipase (EC 3.1.1.3)
HF888_RS04060	ENOG4105BZU	Histidine kinase
HF888_RS04065	ENOG4105WH1	Two component transcriptional regulator luxr family
HF888_RS04070	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HF888_RS04090	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS04110	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HF888_RS04115	ENOG4105C1J	atp-dependent rna helicase
HF888_RS04160	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HF888_RS04165	ENOG4105DDY	UPF0142 protein ycaO
HF888_RS04170	ENOG4107TUY	Histidine kinase
HF888_RS04175	ENOG4105C4K	Nad synthetase
HF888_RS04180	ENOG4105K5M	30s ribosomal protein S16
HF888_RS04185	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HF888_RS04190	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HF888_RS04195	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HF888_RS04200	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HF888_RS04205	ENOG4108UJD	30S ribosomal protein S9
HF888_RS04210	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF888_RS04215	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF888_RS04220	ENOG4105EIX	cytochrome c1
HF888_RS04225	ENOG4107MKT	Stringent starvation protein a
HF888_RS04230	ENOG4105KB2	stringent starvation protein b
HF888_RS04235	ENOG4105CC0	LysR family Transcriptional regulator
HF888_RS04255	ENOG4105D05	Receptor
HF888_RS04265	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HF888_RS04275	ENOG4108VPT	UPF0234 protein
HF888_RS04290	ENOG4108NVR	Methyl-accepting chemotaxis
HF888_RS04295	ENOG4105CHR	reductase
HF888_RS04310	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HF888_RS04325	ENOG4108XKW	General secretion pathway protein C
HF888_RS04330	ENOG4105GVR	general secretion pathway protein D
HF888_RS04335	ENOG4108UHJ	MAF-like protein
HF888_RS04340	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HF888_RS04375	ENOG4105BZU	Histidine kinase
HF888_RS04385	ENOG41090A4	Pterin carbinolamine dehydratase
HF888_RS04410	ENOG4107R0U	MotA TolQ exbB proton channel
HF888_RS04415	ENOG4106VK6	Flagellar motor protein
HF888_RS04430	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HF888_RS04435	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HF888_RS04440	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HF888_RS04445	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HF888_RS04450	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HF888_RS04455	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HF888_RS04465	ENOG4108K5P	(LipO)protein
HF888_RS04470	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF888_RS04475	ENOG4105HEI	LysR family (Transcriptional regulator
HF888_RS04480	ENOG4105F27	Major Facilitator
HF888_RS04485	ENOG4105CV8	reductase
HF888_RS04490	ENOG4108IND	Tetr family transcriptional regulator
HF888_RS04510	ENOG4105VEQ	Cold shock protein
HF888_RS04520	ENOG4108VWS	Yaeq family
HF888_RS04525	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HF888_RS04545	ENOG4105CRK	lysyL-tRNA synthetase
HF888_RS04590	ENOG4109015	Biopolymer transport protein exbD tolR
HF888_RS04595	ENOG41067XB	TonB family
HF888_RS04605	ENOG4108JQ5	ABC transporter
HF888_RS04610	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HF888_RS04620	ENOG4105DEF	Extracellular solute-binding protein, family 5
HF888_RS04645	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
HF888_RS04650	ENOG4105Y75	tpr repeat protein
HF888_RS04660	ENOG4105FQ6	thiopurine methyltransferase
HF888_RS04665	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HF888_RS04670	ENOG4105CSU	acyl-Coa dehydrogenase
HF888_RS04685	ENOG4108YZN	class I peptide chain release factor
HF888_RS04700	ENOG4108IJF	Heavy metal efflux pump, CzcA
HF888_RS04705	ENOG4108JPW	Aminotransferase
HF888_RS04710	ENOG4105EN6	Membrane
HF888_RS04730	ENOG4105DEN	Luciferase family
HF888_RS04735	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HF888_RS04740	ENOG4105C7F	AcnD-accessory protein PrpF
HF888_RS04745	ENOG4108I0Z	Aconitate hydratase
HF888_RS04750	ENOG4105BZN	citrate synthase
HF888_RS04755	ENOG4105CR4	methylisocitrate lyase
HF888_RS04760	ENOG4105DRR	Transcriptional regulator, GntR family
HF888_RS04770	ENOG4105CBC	glutamate synthase
HF888_RS04775	ENOG4108I0Y	(ABC) transporter
HF888_RS04780	ENOG4105CV6	ABC transporter, permease
HF888_RS04795	ENOG4105BZS	acriflavin resistance protein
HF888_RS04815	ENOG4105CDH	Citrulline--aspartate ligase
HF888_RS04830	ENOG4108M3P	Membrane
HF888_RS04845	ENOG4107RNH	Outer membrane receptor FepA
HF888_RS04850	ENOG4108IYU	L-aspartate oxidase
HF888_RS04855	ENOG4105EMN	RNA polymerase sigma factor
HF888_RS04860	ENOG41069E1	anti sigma-E protein RseA
HF888_RS04865	ENOG4105VQK	sigma E regulatory protein, MucB RseB
HF888_RS04875	ENOG4105C0H	protease
HF888_RS04880	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HF888_RS04890	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HF888_RS04895	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HF888_RS04900	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HF888_RS04905	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HF888_RS04910	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HF888_RS04915	ENOG4105BZU	Histidine kinase
HF888_RS04920	ENOG4105C6T	cysteine synthase
HF888_RS04925	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HF888_RS04930	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HF888_RS04935	ENOG4105DXN	mazG family
HF888_RS04940	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
HF888_RS04950	ENOG41072GX	Peptidase M22 Glycoprotease
HF888_RS04960	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HF888_RS04965	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HF888_RS05000	ENOG4105VEQ	Cold shock protein
HF888_RS05015	ENOG4105DHI	Methyltransferase
HF888_RS05025	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HF888_RS05035	ENOG4105EJ2	Transcriptional regulator
HF888_RS05050	ENOG4107TUY	Histidine kinase
HF888_RS05055	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HF888_RS05060	ENOG4105KUZ	arsenate reductase
HF888_RS05075	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HF888_RS05080	ENOG4105CE9	30S ribosomal protein S2
HF888_RS05085	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HF888_RS05090	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HF888_RS05095	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HF888_RS05100	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HF888_RS05105	ENOG4105KNE	Phosphatidate cytidylyltransferase
HF888_RS05110	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HF888_RS05115	ENOG4105DZP	Membrane-associated zinc metalloprotease
HF888_RS05125	ENOG4105X4K	outer membrane chaperone skp
HF888_RS05135	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HF888_RS05140	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HF888_RS05145	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HF888_RS05150	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HF888_RS05170	ENOG4108R6K	riboflavin synthase, subunit alpha
HF888_RS05185	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HF888_RS05190	ENOG4108ZX5	transcriptional regulator
HF888_RS05210	ENOG4105CQ7	ATP-dependent helicase
HF888_RS05215	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS05225	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HF888_RS05230	ENOG4105C29	acyl-CoA thioesterase
HF888_RS05290	ENOG4108ZX5	transcriptional regulator
HF888_RS05320	ENOG4105W53	bacterioferritin-associated ferredoxin
HF888_RS05340	ENOG4105C9Q	fumarate hydratase class II
HF888_RS05345	ENOG4108R86	Transcriptional regulator
HF888_RS05360	ENOG4105C7W	Xanthine dehydrogenase
HF888_RS05370	ENOG4105DHG	Allantoate amidinohydrolase
HF888_RS05380	ENOG4105VT2	5-hydroxyisourate hydrolase
HF888_RS05390	ENOG4107QUY	Guanine deaminase
HF888_RS05410	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HF888_RS05415	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HF888_RS05420	ENOG41060IM	Heme exporter protein
HF888_RS05430	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HF888_RS05435	ENOG4105DA4	cytochrome c-type biogenesis protein
HF888_RS05445	ENOG4105KWW	Biogenesis protein
HF888_RS05460	ENOG4105NBK	UPF0345 protein
HF888_RS05465	ENOG4105ENA	helicase
HF888_RS05480	ENOG4105DSB	aldose 1-epimerase
HF888_RS05485	ENOG4105F8V	Hydrolase, tatD family
HF888_RS05490	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HF888_RS05505	ENOG4105E39	Enoyl-CoA hydratase
HF888_RS05515	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HF888_RS05520	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HF888_RS05540	ENOG4105PE1	Receptor
HF888_RS05550	ENOG4105CA0	peroxidase
HF888_RS05565	ENOG4109015	Biopolymer transport protein exbD tolR
HF888_RS05590	ENOG4105CC0	LysR family Transcriptional regulator
HF888_RS05595	ENOG4108VGI	doxx family
HF888_RS05600	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HF888_RS05610	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HF888_RS05615	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HF888_RS05630	ENOG4105C3Q	Glycosyl transferase, family 2
HF888_RS05645	ENOG4108QIF	Phosphoesterase, PA-phosphatase related
HF888_RS05665	ENOG4107QJE	Chromosome Partitioning Protein
HF888_RS05705	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HF888_RS05710	ENOG4105C5X	domain protein
HF888_RS05720	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HF888_RS05740	ENOG4108VKM	cytochrome b561
HF888_RS05765	ENOG41081YB	ApbE family
HF888_RS05770	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HF888_RS05775	ENOG4105DHQ	Histidine kinase
HF888_RS05780	ENOG4107RDP	Dehydrogenase
HF888_RS05785	ENOG4107RUY	(E1 component), alpha subunit
HF888_RS05790	ENOG4105CPP	Dehydrogenase, E1 component
HF888_RS05795	ENOG4105C7S	Dehydrogenase
HF888_RS05815	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HF888_RS05830	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HF888_RS05835	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HF888_RS05855	ENOG4108RG0	uracil-dna glycosylase
HF888_RS05865	ENOG4105DHT	Metal Dependent Phosphohydrolase
HF888_RS05870	ENOG4105C9M	aspartyl-trna synthetase
HF888_RS05875	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HF888_RS05880	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HF888_RS05885	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HF888_RS05890	ENOG4107YD3	Thioesterase
HF888_RS05895	ENOG4105E02	MotA TolQ exbB proton channel
HF888_RS05900	ENOG4105M8F	Biopolymer transport protein exbD tolR
HF888_RS05910	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HF888_RS05915	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HF888_RS05935	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HF888_RS05940	ENOG4105ERG	peptidase m48, ste24p
HF888_RS05945	ENOG4105VFE	sira family
HF888_RS05955	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HF888_RS05965	ENOG4105Q2H	domain protein
HF888_RS05980	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HF888_RS05995	ENOG4105CPI	Metal Dependent Phosphohydrolase
HF888_RS06005	ENOG4105C3F	Signal peptidase i
HF888_RS06020	ENOG4105BZU	Histidine kinase
HF888_RS06025	ENOG4108TKH	Nitroreductase
HF888_RS06035	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HF888_RS06040	ENOG4105CFP	Peptidase U32
HF888_RS06065	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HF888_RS06125	ENOG4105CEY	Amp-dependent synthetase and ligase
HF888_RS06130	ENOG4105CQ7	ATP-dependent helicase
HF888_RS06140	ENOG4105E18	UPF0276 protein
HF888_RS06155	ENOG410903C	(LipO)protein
HF888_RS06165	ENOG4105I93	response regulator
HF888_RS06175	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HF888_RS06200	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
HF888_RS06215	ENOG4105D3G	Pseudouridine synthase
HF888_RS06230	ENOG4105DH7	May be involved in recombination (By similarity)
HF888_RS06250	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HF888_RS06255	ENOG4107S1Q	Phosphatase
HF888_RS06260	ENOG4105EBW	Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity)
HF888_RS06265	ENOG4105VUT	cytoplasmic protein
HF888_RS06275	ENOG4105CD8	aminopeptidase N
HF888_RS06280	ENOG4105D25	secreted protein
HF888_RS06285	ENOG4107SP2	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity
HF888_RS06295	ENOG4108W1A	pseudouridine synthase
HF888_RS06300	ENOG4105CHU	acetyl-coa acetyltransferase
HF888_RS06310	ENOG41080IJ	Diacylglycerol kinase
HF888_RS06330	ENOG4107VQW	regulatoR
HF888_RS06335	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HF888_RS06340	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HF888_RS06345	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HF888_RS06360	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HF888_RS06370	ENOG4105CVI	Transcriptional regulator
HF888_RS06385	ENOG4105BZU	Histidine kinase
HF888_RS06390	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF888_RS06400	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HF888_RS06415	ENOG4105BZU	Histidine kinase
HF888_RS06425	ENOG4108ZX5	transcriptional regulator
HF888_RS06430	ENOG4108YYH	Nadph-dependent fmn reductase
HF888_RS06445	ENOG4105BZU	Histidine kinase
HF888_RS06450	ENOG4105UBK	short-chain dehydrogenase reductase
HF888_RS06455	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HF888_RS06465	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HF888_RS06470	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF888_RS06480	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HF888_RS06485	ENOG4105CQC	Prephenate dehydratase
HF888_RS06490	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HF888_RS06495	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HF888_RS06500	ENOG4105CAT	Cytidine monophosphate kinase
HF888_RS06505	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HF888_RS06530	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HF888_RS06535	ENOG4107QP8	phosphohexose isomerase
HF888_RS06540	ENOG4105CY0	Metallo-Beta-Lactamase
HF888_RS06545	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HF888_RS06550	ENOG4105CMR	udp-glucose 4-epimerase
HF888_RS06555	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HF888_RS06560	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HF888_RS06615	ENOG4108RYC	glycosyltransferase
HF888_RS06640	ENOG4105DBV	ornithine carbamoyltransferase
HF888_RS06645	ENOG4105C8Y	Acetylornithine aminotransferase
HF888_RS06650	ENOG4105M2J	Glutaredoxin
HF888_RS06655	ENOG4105CVA	phosphate
HF888_RS06660	ENOG4105WD1	Membrane
HF888_RS06670	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HF888_RS06690	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
HF888_RS06695	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HF888_RS06705	ENOG4105M85	Bola protein
HF888_RS06720	ENOG4105C26	Dehydrogenase
HF888_RS06740	ENOG410630P	Transcriptional regulator
HF888_RS06745	ENOG4108R6W	Transcriptional regulator, ARAC family
HF888_RS06750	ENOG4108IQE	Amp-dependent synthetase and ligase
HF888_RS06755	ENOG41069FQ	Metallo-beta-lactamase superfamily
HF888_RS06765	ENOG4108ZX5	transcriptional regulator
HF888_RS06780	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HF888_RS06790	ENOG4105FE9	pseudouridine synthase
HF888_RS06795	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HF888_RS06800	ENOG4108RWN	rrna methyltransferase
HF888_RS06850	ENOG4105EIF	outer membrane protein W
HF888_RS06855	ENOG4108RZE	Tetr family transcriptional regulator
HF888_RS06860	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HF888_RS06865	ENOG4107QX3	carboxylase
HF888_RS06870	ENOG4105C1G	acyl-Coa dehydrogenase
HF888_RS06875	ENOG4105E39	Enoyl-CoA hydratase
HF888_RS06885	ENOG4105C1G	acyl-Coa dehydrogenase
HF888_RS06900	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HF888_RS06915	ENOG4105D7T	ABC transporter
HF888_RS06920	ENOG4108UMI	ABC transporter, permease
HF888_RS06930	ENOG4105EGI	Transcriptional regulator
HF888_RS06940	ENOG4105VSH	4-oxalocrotonate tautomerase
HF888_RS06950	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HF888_RS06960	ENOG4105CX6	glutaminyL-tRNA synthetase
HF888_RS06965	ENOG4105C8N	cysteinyl-tRNA synthetase
HF888_RS06970	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HF888_RS06980	ENOG4107RBR	Receptor
HF888_RS07000	ENOG4105C8J	)-transporter
HF888_RS07015	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HF888_RS07035	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HF888_RS07060	ENOG4105XEA	Tetr family transcriptional regulator
HF888_RS07065	ENOG4107Y2H	ErfK ybiS ycfS ynhG family protein
HF888_RS07070	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
HF888_RS07075	ENOG4105D64	Mechanosensitive ion channel
HF888_RS07080	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
HF888_RS07090	ENOG4108JA2	transcriptioN-repair coupling factor
HF888_RS07100	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HF888_RS07105	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HF888_RS07110	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HF888_RS07115	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HF888_RS07120	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HF888_RS07125	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HF888_RS07145	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HF888_RS07235	ENOG4108WC9	type VI secretion system effector, hcp1 family
HF888_RS07305	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HF888_RS07315	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HF888_RS07320	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HF888_RS07340	ENOG4105CJ2	(LipO)protein
HF888_RS07350	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
HF888_RS07365	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HF888_RS07370	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HF888_RS07385	ENOG4105D1Q	UPF0246 protein
HF888_RS07400	ENOG4105CN1	protease
HF888_RS07410	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HF888_RS07430	ENOG4105D60	lipoprotein releasing system transmembrane protein
HF888_RS07435	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HF888_RS07445	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HF888_RS07455	ENOG4109015	Biopolymer transport protein exbD tolR
HF888_RS07460	ENOG4105BZ1	(ABC) transporter
HF888_RS07470	ENOG4105W49	UPF0434 protein
HF888_RS07475	ENOG41063SB	peptidase
HF888_RS07485	ENOG4105D4A	Cell wall formation (By similarity)
HF888_RS07490	ENOG4105C03	ribonuclease
HF888_RS07495	ENOG4105EI2	Pseudouridine synthase
HF888_RS07510	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HF888_RS07515	ENOG4105VGS	50s ribosomal protein l32
HF888_RS07520	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HF888_RS07525	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HF888_RS07530	ENOG4105CHR	reductase
HF888_RS07535	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HF888_RS07540	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HF888_RS07545	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HF888_RS07550	ENOG4105HHA	aminodeoxychorismate lyase
HF888_RS07555	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HF888_RS07560	ENOG4107QRG	dna polymerase iii
HF888_RS07580	ENOG4105CQB	FAD linked oxidase domain protein
HF888_RS07585	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HF888_RS07590	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HF888_RS07615	ENOG4105D58	Diguanylate phosphodiesterase
HF888_RS07625	ENOG4105QVC	MOSC domain-containing protein
HF888_RS07635	ENOG4107SC1	transglycosylase
HF888_RS07640	ENOG4105C5H	ABC transporter
HF888_RS07655	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HF888_RS07660	ENOG4105CHU	acetyl-coa acetyltransferase
HF888_RS07675	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HF888_RS07690	ENOG4105CD5	CoA-binding domain protein
HF888_RS07695	ENOG4105WH1	Two component transcriptional regulator luxr family
HF888_RS07700	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HF888_RS07750	ENOG4105VZ1	Replication Protein
HF888_RS07820	ENOG41082BV	acetyltransferase
HF888_RS07825	ENOG4105EZE	Cupin 4 family protein
HF888_RS07830	ENOG4107QTF	adenylosuccinate lyase
HF888_RS07835	ENOG4105E68	Sulfatase
HF888_RS07840	ENOG41075W9	High frequency lysogenization protein HflD homolog
HF888_RS07855	ENOG4108R99	pseudouridine synthase
HF888_RS07860	ENOG4105E9K	Isocitrate dehydrogenase
HF888_RS07865	ENOG4105VEQ	Cold shock protein
HF888_RS07870	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HF888_RS07875	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HF888_RS07880	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HF888_RS07885	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HF888_RS07890	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HF888_RS07895	ENOG4105CNU	cell division protein FtsK
HF888_RS07900	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
HF888_RS07905	ENOG4105D1H	recombination factor protein RarA
HF888_RS07910	ENOG4105WMR	Protein CrcB homolog
HF888_RS07915	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HF888_RS07920	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HF888_RS07925	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS07955	ENOG4109015	Biopolymer transport protein exbD tolR
HF888_RS07960	ENOG410822N	TonB family
HF888_RS07970	ENOG4105CGK	Exodeoxyribonuclease III
HF888_RS07980	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HF888_RS07985	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF888_RS07990	ENOG4105EKE	dihydroorotase
HF888_RS07995	ENOG4105BZS	acriflavin resistance protein
HF888_RS08000	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HF888_RS08020	ENOG4105BZU	Histidine kinase
HF888_RS08035	ENOG4105C0B	DNA polymerase III (alpha subunit)
HF888_RS08080	ENOG4107QP3	malate synthase g
HF888_RS08085	ENOG4105XZD	Fe-S protein
HF888_RS08100	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HF888_RS08105	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HF888_RS08115	ENOG4105CZX	twitching motility protein
HF888_RS08130	ENOG4105DC8	reductase
HF888_RS08140	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HF888_RS08145	ENOG4108RTD	type II secretion system protein K
HF888_RS08150	ENOG4108WWZ	General secretion pathway protein J
HF888_RS08155	ENOG4105X5Z	General secretion pathway protein I
HF888_RS08160	ENOG4105VWV	general secretion pathway protein h
HF888_RS08165	ENOG4108VAU	general secretion pathway protein G
HF888_RS08170	ENOG4105D7Q	type ii secretion system
HF888_RS08175	ENOG4107QHF	type ii secretion system protein e
HF888_RS08180	ENOG4105C10	Electron transfer flavoprotein
HF888_RS08185	ENOG4105BZJ	Electron transfer flavoprotein
HF888_RS08190	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HF888_RS08205	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
HF888_RS08225	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HF888_RS08255	ENOG4105CRQ	synthase (Component I)
HF888_RS08260	ENOG4105ECA	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein
HF888_RS08270	ENOG4107R11	Transcriptional regulator
HF888_RS08285	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HF888_RS08295	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HF888_RS08300	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
HF888_RS08305	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HF888_RS08325	ENOG4105ERU	peptidase
HF888_RS08345	ENOG4107RZZ	dna polymerase iii epsilon subunit
HF888_RS08350	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HF888_RS08355	ENOG4105D1A	Methyltransferase
HF888_RS08360	ENOG4105E9H	Lytic Murein transglycosylase
HF888_RS08365	ENOG4108J59	Extracellular solute-binding protein, family 5
HF888_RS08370	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HF888_RS08375	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HF888_RS08380	ENOG4105K70	DNA-binding protein
HF888_RS08385	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HF888_RS08390	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HF888_RS08395	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HF888_RS08400	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HF888_RS08410	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HF888_RS08415	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HF888_RS08420	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HF888_RS08425	ENOG4105BZU	Histidine kinase
HF888_RS08455	ENOG4108K3A	Glutathione S-transferase
HF888_RS08460	ENOG4105DVT	helicase
HF888_RS08490	ENOG4107RET	Isocitrate lyase
HF888_RS08505	ENOG4108MN8	Membrane
HF888_RS08510	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
HF888_RS08515	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HF888_RS08530	ENOG4108MTB	glycosyl transferase family
HF888_RS08550	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HF888_RS08555	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HF888_RS08570	ENOG4107S2Z	UPF0761 membrane protein
HF888_RS08575	ENOG4105K89	arsenate reductase
HF888_RS08580	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HF888_RS08600	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
HF888_RS08605	ENOG4105C02	permease
HF888_RS08610	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HF888_RS08620	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HF888_RS08625	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HF888_RS08670	ENOG4105BZU	Histidine kinase
HF888_RS08680	ENOG410829K	Lysine exporter protein (Lyse ygga)
HF888_RS08685	ENOG4105DHP	deoxycytidine triphosphate deaminase
HF888_RS08690	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HF888_RS08705	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HF888_RS08715	ENOG4105DGN	Electron transport complex
HF888_RS08720	ENOG4108R3D	Electron transport complex
HF888_RS08730	ENOG4105D6A	Electron transport complex
HF888_RS08735	ENOG4108UQQ	Electron transport complex
HF888_RS08740	ENOG4105DZB	Electron transport complex
HF888_RS08745	ENOG4105CSM	endonuclease III
HF888_RS08750	ENOG4108UYE	Lactoylglutathione lyase
HF888_RS08755	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
HF888_RS08765	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HF888_RS08790	ENOG4105C3R	Methionine synthase
HF888_RS08795	ENOG4105C3R	Methionine synthase
HF888_RS08805	ENOG4107RN6	Monooxygenase
HF888_RS08820	ENOG4105D74	hydrolase
HF888_RS08825	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HF888_RS08840	ENOG41069NU	Nitroreductase
HF888_RS08845	ENOG4105F8J	Adenylate Guanylate cyclase
HF888_RS08855	ENOG4105DHT	Metal Dependent Phosphohydrolase
HF888_RS08865	ENOG4105F8C	transglutaminase domain-containing protein
HF888_RS08875	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HF888_RS08880	ENOG4105C28	cystathionine
HF888_RS08885	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HF888_RS08890	ENOG4105E96	Colicin v production protein
HF888_RS08900	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HF888_RS08905	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HF888_RS08915	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HF888_RS08920	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HF888_RS08930	ENOG4105C5H	ABC transporter
HF888_RS08935	ENOG4105EGS	Mechanosensitive ion channel
HF888_RS08940	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HF888_RS08945	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HF888_RS08950	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HF888_RS08955	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HF888_RS08960	ENOG4108MP6	LysR family Transcriptional regulator
HF888_RS08965	ENOG4105Q9Y	Universal stress protein
HF888_RS08980	ENOG4105EW9	transcriptional regulator AsnC family
HF888_RS08985	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HF888_RS08990	ENOG41069D7	Methyl-accepting chemotaxis
HF888_RS09010	ENOG4105C09	Bile acid
HF888_RS09015	ENOG4108ZX5	transcriptional regulator
HF888_RS09020	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS09025	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HF888_RS09030	ENOG4105DFI	Membrane
HF888_RS09045	ENOG4108IJ7	Glycine betaine
HF888_RS09060	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
HF888_RS09065	ENOG4105C26	Dehydrogenase
HF888_RS09075	ENOG4105C1J	atp-dependent rna helicase
HF888_RS09110	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HF888_RS09115	ENOG4105KK4	UPF0060 membrane protein
HF888_RS09170	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HF888_RS09175	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HF888_RS09185	ENOG4105C7S	Dehydrogenase
HF888_RS09190	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HF888_RS09195	ENOG4105E33	succinate dehydrogenase
HF888_RS09200	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HF888_RS09205	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HF888_RS09210	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HF888_RS09215	ENOG4105BZN	citrate synthase
HF888_RS09220	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HF888_RS09245	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HF888_RS09250	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS09255	ENOG4105D8G	Major Facilitator superfamily
HF888_RS09260	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HF888_RS09265	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HF888_RS09310	ENOG4105DAN	ATP-dependent protease
HF888_RS09315	ENOG4105BZU	Histidine kinase
HF888_RS09350	ENOG4105E3A	(ABC) transporter
HF888_RS09355	ENOG4105DA5	(ABC) transporter
HF888_RS09390	ENOG4105K56	Transcriptional regulator
HF888_RS09395	ENOG4108V06	Glutathione peroxidase
HF888_RS09405	ENOG4105E0X	reductase
HF888_RS09410	ENOG4105CHM	Aminotransferase
HF888_RS09420	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HF888_RS09430	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HF888_RS09450	ENOG4108BPE	-transporting atpase
HF888_RS09455	ENOG4107QI1	Mate efflux family protein
HF888_RS09465	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HF888_RS09490	ENOG4105NXH	GreA GreB family elongation factor
HF888_RS09510	ENOG4105EXG	Transcriptional regulator
HF888_RS09520	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HF888_RS09525	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
HF888_RS09615	ENOG4108V5Q	transglutaminase-like protein
HF888_RS09625	ENOG4105EQR	Transposase IS116 IS110 IS902
HF888_RS09635	ENOG4105CPC	Aldo Keto reductase
HF888_RS09655	ENOG4108R96	Methyltransferase, YaeB family
HF888_RS09665	ENOG4105BZU	Histidine kinase
HF888_RS09680	ENOG4108ZX5	transcriptional regulator
HF888_RS09685	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HF888_RS09690	ENOG4105RKW	reductase (By
HF888_RS09700	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HF888_RS09705	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
HF888_RS09715	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HF888_RS09730	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HF888_RS09770	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HF888_RS09780	ENOG4108RRZ	Transcription elongation factor GreB
HF888_RS09790	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF888_RS09830	ENOG4108PTX	LysR family Transcriptional regulator
HF888_RS09845	ENOG4105HDK	L-asparaginase
HF888_RS09865	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HF888_RS09870	ENOG41069YE	inner membrane protein yohC
HF888_RS09880	ENOG4105BZU	Histidine kinase
HF888_RS09900	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
HF888_RS09905	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HF888_RS09915	ENOG4105C7I	Dehydrogenase
HF888_RS09920	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HF888_RS09940	ENOG4107QVM	von Willebrand factor, type A
HF888_RS09960	ENOG4105D5P	Methylmalonyl-coA mutase
HF888_RS09970	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HF888_RS09975	ENOG4105C72	UPF0176 protein
HF888_RS09980	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HF888_RS09990	ENOG41080HT	Transcriptional regulator, arsr family
HF888_RS09995	ENOG4105CHH	sulfate transporter
HF888_RS10000	ENOG4105XCT	Protein of unknown function (DUF2489)
HF888_RS10030	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF888_RS10070	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HF888_RS10080	ENOG4105CFV	Tetratricopeptide repeat protein
HF888_RS10090	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HF888_RS10095	ENOG4108JJ7	ABC transporter
HF888_RS10105	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HF888_RS10110	ENOG4108ZG0	Ompa motb domain protein
HF888_RS10115	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HF888_RS10120	ENOG4105MD1	YeeE YedE family protein
HF888_RS10130	ENOG4105D3R	alkyl hydroperoxide reductase
HF888_RS10140	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HF888_RS10145	ENOG4108TGP	Thioesterase superfamily protein
HF888_RS10155	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HF888_RS10160	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HF888_RS10165	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HF888_RS10170	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HF888_RS10175	ENOG41082NX	50s ribosomal protein l35
HF888_RS10180	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HF888_RS10185	ENOG4105C22	threonyL-tRNA synthetase
HF888_RS10215	ENOG4105CKT	filamentous hemagglutinin
HF888_RS10215	ENOG4105CKT	filamentous hemagglutinin
HF888_RS10220	ENOG4105D5K	Hemolysin activator protein
HF888_RS10235	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HF888_RS10245	ENOG4108R4R	Iron-regulated virulence regulatory protein
HF888_RS10250	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HF888_RS10260	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HF888_RS10265	ENOG4107QIJ	Aconitate hydratase 2
HF888_RS10285	ENOG4105CIS	alcohol dehydrogenase
HF888_RS10290	ENOG4105BZ1	(ABC) transporter
HF888_RS10305	ENOG4105BZ1	(ABC) transporter
HF888_RS10310	ENOG4105DZ2	Transcriptional regulator
HF888_RS10315	ENOG4105JJR	Histidine kinase
HF888_RS10320	ENOG4107EXC	regulatoR
HF888_RS10325	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF888_RS10330	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF888_RS10335	ENOG4105XPH	Ferredoxin
HF888_RS10340	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF888_RS10375	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HF888_RS10380	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HF888_RS10390	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF888_RS10400	ENOG4105EUB	pirin domain protein
HF888_RS10410	ENOG4105CYW	agmatinase
HF888_RS10415	ENOG41064T2	transcriptional regulator, lysR family
HF888_RS10425	ENOG4108JUA	Transcriptional regulator
HF888_RS10430	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HF888_RS10445	ENOG4106HNH	Acyl-transferase
HF888_RS10450	ENOG4105BZU	Histidine kinase
HF888_RS10455	ENOG4105CK7	Sodium proline symporter
HF888_RS10475	ENOG4105CJP	fad dependent oxidoreductase
HF888_RS10485	ENOG4105C26	Dehydrogenase
HF888_RS10490	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HF888_RS10495	ENOG4105C26	Dehydrogenase
HF888_RS10505	ENOG4105CJP	fad dependent oxidoreductase
HF888_RS10520	ENOG4105ECQ	AraC Family Transcriptional Regulator
HF888_RS10545	ENOG4105CVI	Transcriptional regulator
HF888_RS10680	ENOG4108V5Q	transglutaminase-like protein
HF888_RS10710	ENOG410642W	LysR family Transcriptional regulator
HF888_RS10715	ENOG4105C01	Dihydroxy-acid dehydratase
HF888_RS10720	ENOG4108UHU	Aldolase
HF888_RS10730	ENOG4105CFQ	glutamine synthetase
HF888_RS10735	ENOG4105C26	Dehydrogenase
HF888_RS10750	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HF888_RS10755	ENOG4105F38	ABC transporter, permease
HF888_RS10760	ENOG4105D38	putrescine abc transporter
HF888_RS10770	ENOG4105CF1	Alkylated DNA repair protein
HF888_RS10800	ENOG4105FE9	pseudouridine synthase
HF888_RS10805	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HF888_RS10810	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HF888_RS10815	ENOG4105C31	Tryptophanyl-tRNA synthetase
HF888_RS10820	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HF888_RS10825	ENOG4105DB7	PHP domain protein
HF888_RS10835	ENOG4105K9H	YciI-like protein
HF888_RS10840	ENOG4106MWK	domain protein
HF888_RS10845	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HF888_RS10855	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HF888_RS10875	ENOG4105YP7	UPF0270 protein
HF888_RS10890	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HF888_RS10895	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
HF888_RS10930	ENOG41084HI	prevent-host-death family
HF888_RS10940	ENOG4107Y70	Heat shock protein
HF888_RS10945	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HF888_RS10970	ENOG4106IUH	DTW domain containing protein
HF888_RS10985	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HF888_RS11000	ENOG4105C0A	alcohol dehydrogenase
HF888_RS11020	ENOG4105D6S	protein involved in catabolism of external DNA
HF888_RS11025	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HF888_RS11040	ENOG4106371	Methyltransferase
HF888_RS11045	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HF888_RS11050	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HF888_RS11070	ENOG4105DR9	pseudouridine synthase
HF888_RS11075	ENOG4105CEY	Amp-dependent synthetase and ligase
HF888_RS11085	ENOG4108Z6Z	Transcriptional regulator
HF888_RS11090	ENOG4105C1G	acyl-Coa dehydrogenase
HF888_RS11095	ENOG4107QX3	carboxylase
HF888_RS11100	ENOG4105CGU	Enoyl-CoA hydratase
HF888_RS11110	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
HF888_RS11140	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HF888_RS11145	ENOG4108HM4	ABC transporter
HF888_RS11150	ENOG4105D4P	Coproporphyrinogen iii oxidase
HF888_RS11175	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HF888_RS11195	ENOG4107RJ1	sodium solute
HF888_RS11210	ENOG4108ZZ3	UPF0260 protein
HF888_RS11215	ENOG4105VNG	YcgL domain-containing protein
HF888_RS11225	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HF888_RS11230	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HF888_RS11235	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HF888_RS11245	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HF888_RS11250	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HF888_RS11255	ENOG4105BZU	Histidine kinase
HF888_RS11265	ENOG4105CHR	reductase
HF888_RS11280	ENOG4108Z20	Acyl-transferase
HF888_RS11300	ENOG4108ZJT	translation initiation factor, Sui1
HF888_RS11310	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HF888_RS11315	ENOG4105C6K	Malic enzyme
HF888_RS11320	ENOG4106HNH	Acyl-transferase
HF888_RS11330	ENOG41076HS	cation diffusion facilitator family transporter
HF888_RS11335	ENOG4108VYJ	response regulator receiver protein
HF888_RS11370	ENOG4107QXK	peptidase
HF888_RS11385	ENOG4105KCV	RNA signal recognition particle 4.5S RNA
HF888_RS11400	ENOG4105DGI	Alkaline phosphatase
HF888_RS11415	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
HF888_RS11420	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HF888_RS11440	ENOG4108JU3	Alkyl hydroperoxide reductase
HF888_RS11445	ENOG4105D3R	alkyl hydroperoxide reductase
HF888_RS11460	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HF888_RS11465	ENOG4105CCT	upf0313 protein
HF888_RS11495	ENOG4108UJV	acyl-CoA thioesterase i
HF888_RS11500	ENOG4105CJB	Exodeoxyribonuclease I
HF888_RS11545	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HF888_RS11550	ENOG4108UT2	hemolysin iii
HF888_RS11560	ENOG41077A9	carbonic anhydrase
HF888_RS11565	ENOG4105D06	uba thif-type nad fad binding protein
HF888_RS11575	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HF888_RS11585	ENOG4105CUZ	uba thif-type nad fad binding protein
HF888_RS11605	ENOG4105CR8	Transcriptional regulator
HF888_RS11615	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HF888_RS11620	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HF888_RS11625	ENOG4105D25	secreted protein
HF888_RS11630	ENOG4105EYA	deoxyribonuclease
HF888_RS11640	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HF888_RS11650	ENOG4108W15	Protein of unknown function (DUF1456)
HF888_RS11660	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HF888_RS11665	ENOG4107QYX	exodeoxyribonuclease v alpha
HF888_RS11670	ENOG4107QKA	exodeoxyribonuclease V beta
HF888_RS11675	ENOG4105DSY	exodeoxyribonuclease V, gamma
HF888_RS11705	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HF888_RS11710	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HF888_RS11715	ENOG4105BZU	Histidine kinase
HF888_RS11720	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF888_RS11730	ENOG41080ET	plasmid maintenance system killer protein
HF888_RS11745	ENOG4105DZ2	Transcriptional regulator
HF888_RS11755	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF888_RS11760	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HF888_RS11765	ENOG4108MN8	Membrane
HF888_RS11775	ENOG41063Z6	transcriptional regulator, lysR family
HF888_RS11790	ENOG4105C72	UPF0176 protein
HF888_RS11800	ENOG4108V3W	Chemotaxis protein, CheW
HF888_RS11815	ENOG4107QJE	Chromosome Partitioning Protein
HF888_RS11820	ENOG4105ER2	Ompa motb domain protein
HF888_RS11825	ENOG4105E14	MotA TolQ exbB proton channel
HF888_RS11830	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HF888_RS11840	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HF888_RS11845	ENOG4108VYJ	response regulator receiver protein
HF888_RS11850	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF888_RS11860	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HF888_RS11865	ENOG4105D7B	Flagellar biosynthesis protein flha
HF888_RS11875	ENOG4105D00	flagellar biosynthetic protein flhB
HF888_RS11880	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HF888_RS11885	ENOG4105VS8	Flagellar biosynthetic protein fliq
HF888_RS11890	ENOG4105CN7	Flagellar biosynthetic protein FliP
HF888_RS11895	ENOG4105VTB	flagellar biosynthesis protein fliO
HF888_RS11900	ENOG4105DD5	Flagellar motor switch protein
HF888_RS11905	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HF888_RS11925	ENOG4105M3Z	response regulator
HF888_RS11935	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HF888_RS11940	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
HF888_RS11945	ENOG4105BZU	Histidine kinase
HF888_RS11950	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS11955	ENOG4108V3W	Chemotaxis protein, CheW
HF888_RS11960	ENOG4105CBS	Chea signal transduction histidine kinase
HF888_RS11965	ENOG4108VYJ	response regulator receiver protein
HF888_RS11980	ENOG4108JIR	Flagellum-specific ATP synthase
HF888_RS11990	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HF888_RS11995	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HF888_RS12000	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HF888_RS12010	ENOG4107TUY	Histidine kinase
HF888_RS12020	ENOG4105MQ3	flagellar protein FliS
HF888_RS12030	ENOG4105DTS	flagellar hook-associated
HF888_RS12060	ENOG4105I2C	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HF888_RS12065	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HF888_RS12085	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HF888_RS12090	ENOG4105C5E	polysaccharide biosynthesis protein
HF888_RS12095	ENOG4105DTJ	flagellar hook-associated protein
HF888_RS12100	ENOG4105E1Q	flagellar hook-associated protein
HF888_RS12105	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HF888_RS12115	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HF888_RS12120	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HF888_RS12125	ENOG4105CGA	flagellar basal-body rod protein FlgG
HF888_RS12130	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HF888_RS12135	ENOG4105BZE	flagellar hook protein, FlgE
HF888_RS12140	ENOG4105W00	Flagellar hook capping protein
HF888_RS12145	ENOG4108ZC9	flagellar basal-body rod protein flgc
HF888_RS12150	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HF888_RS12155	ENOG4105BZU	Histidine kinase
HF888_RS12190	ENOG4105CKK	Glycosyl transferase, family 2
HF888_RS12210	ENOG4108HYG	acetyltransferase
HF888_RS12285	ENOG4105EQR	Transposase IS116 IS110 IS902
HF888_RS12340	ENOG4105EG6	Saccharopine dehydrogenase
HF888_RS12360	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HF888_RS12375	ENOG4105F1N	DNA alkylation repair
HF888_RS12380	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HF888_RS12385	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HF888_RS12390	ENOG4108HU6	Metal dependent phosphohydrolase
HF888_RS12395	ENOG4105DXI	Major Facilitator superfamily
HF888_RS12400	ENOG4105EA8	2-Nitropropane dioxygenase
HF888_RS12410	ENOG4108ZP8	Acetolactate synthase small subunit
HF888_RS12415	ENOG4105C7K	acetolactate synthase
HF888_RS12425	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HF888_RS12430	ENOG4105C34	Pseudouridine synthase
HF888_RS12435	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF888_RS12440	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HF888_RS12450	ENOG4108JU6	CBS domain protein
HF888_RS12470	ENOG4108Z0R	Transferase
HF888_RS12475	ENOG4105P8F	nudix hydrolase
HF888_RS12485	ENOG4105E09	nadh pyrophosphatase
HF888_RS12490	ENOG4105EGD	dinuclear metal center protein, YbgI family
HF888_RS12495	ENOG4105KRS	Proteinase inhibitor
HF888_RS12530	ENOG4105C8V	SAICAR synthetase
HF888_RS12565	ENOG4105D9Q	decarboxylase (Beta subunit)
HF888_RS12570	ENOG4107QSA	Oxaloacetate decarboxylase
HF888_RS12575	ENOG4106AFN	Lyase and sodium transporter (By similarity)
HF888_RS12580	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HF888_RS12585	ENOG4105BZU	Histidine kinase
HF888_RS12600	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HF888_RS12605	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HF888_RS12615	ENOG4108Z66	YbaK ebsC protein
HF888_RS12645	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HF888_RS12650	ENOG4105CFH	Aspartokinase
HF888_RS12655	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HF888_RS12680	ENOG4105CEP	NADH dehydrogenase
HF888_RS12695	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HF888_RS12700	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HF888_RS12705	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HF888_RS12710	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HF888_RS12715	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HF888_RS12720	ENOG4105MJ2	Competence protein
HF888_RS12725	ENOG4105E27	serine threonine protein kinase
HF888_RS12740	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HF888_RS12750	ENOG4105F4X	arginine
HF888_RS12755	ENOG4105C8Y	Acetylornithine aminotransferase
HF888_RS12760	ENOG4105EW9	transcriptional regulator AsnC family
HF888_RS12765	ENOG4105CDU	Replicative dna helicase
HF888_RS12770	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HF888_RS12775	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF888_RS12780	ENOG4105K46	50S ribosomal protein l27
HF888_RS12785	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HF888_RS12790	ENOG4105EAH	synthase
HF888_RS12795	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HF888_RS12805	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HF888_RS12815	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HF888_RS12820	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HF888_RS12835	ENOG4105DS1	cytochrome b561
HF888_RS12840	ENOG4108YYC	ycei family
HF888_RS12850	ENOG4105C09	Bile acid
HF888_RS12855	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HF888_RS12860	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HF888_RS12865	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HF888_RS12870	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HF888_RS12875	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HF888_RS12880	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HF888_RS12885	ENOG4105CHV	Transcription elongation factor NusA
HF888_RS12890	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HF888_RS12905	ENOG4107EJC	Preprotein translocase subunit SecG
HF888_RS12910	ENOG4105CP7	Triose-phosphate isomerase
HF888_RS12920	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HF888_RS12925	ENOG4105HBR	Rna-binding protein
HF888_RS12930	ENOG4108NVR	Methyl-accepting chemotaxis
HF888_RS12935	ENOG4107QSN	dihydrolipoamide acetyltransferase
HF888_RS12940	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HF888_RS12945	ENOG4107TB6	phosphoglycerate mutase
HF888_RS12950	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HF888_RS12955	ENOG4108YZT	Adenosylcobinamide kinase
HF888_RS12965	ENOG4105DKQ	ROK family
HF888_RS12975	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HF888_RS12980	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HF888_RS13000	ENOG4107QHF	type ii secretion system protein e
HF888_RS13010	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HF888_RS13015	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HF888_RS13025	ENOG4105M6F	mutator MutT protein
HF888_RS13030	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HF888_RS13035	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HF888_RS13040	ENOG4105DR5	peptidase
HF888_RS13045	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HF888_RS13050	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HF888_RS13055	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HF888_RS13060	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HF888_RS13065	ENOG4105CPF	Cell wall formation (By similarity)
HF888_RS13070	ENOG4105DFU	Cell wall formation (By similarity)
HF888_RS13075	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HF888_RS13080	ENOG4105CNI	cell division protein FtsW
HF888_RS13085	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HF888_RS13090	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HF888_RS13095	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HF888_RS13100	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HF888_RS13105	ENOG4105CJN	penicillin-binding protein
HF888_RS13115	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HF888_RS13120	ENOG4108V6E	Cell division protein mraZ
HF888_RS13130	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HF888_RS13135	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HF888_RS13140	ENOG41082RQ	UPF0102 protein
HF888_RS13160	ENOG4108ETH	Formylglycinamide ribotide synthetase
HF888_RS13165	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HF888_RS13180	ENOG4105ECY	inositol monophosphatase
HF888_RS13190	ENOG4105C1J	atp-dependent rna helicase
HF888_RS13195	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HF888_RS13200	ENOG4105C0B	DNA polymerase III (alpha subunit)
HF888_RS13215	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HF888_RS13220	ENOG4105E0F	Histidine kinase
HF888_RS13235	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS13245	ENOG4105F8J	Adenylate Guanylate cyclase
HF888_RS13275	ENOG4105CFC	Transporter
HF888_RS13290	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HF888_RS13305	ENOG4105M3Z	response regulator
HF888_RS13330	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HF888_RS13335	ENOG4107QMS	site-determining protein
HF888_RS13340	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HF888_RS13350	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HF888_RS13355	ENOG4105ECY	inositol monophosphatase
HF888_RS13360	ENOG4105MGK	May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity)
HF888_RS13365	ENOG4107IFA	Lipase (EC 3.1.1.3)
HF888_RS13370	ENOG4105CSU	acyl-Coa dehydrogenase
HF888_RS13385	ENOG4105BZU	Histidine kinase
HF888_RS13390	ENOG4108S4H	thioesterase Superfamily protein
HF888_RS13395	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HF888_RS13400	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
HF888_RS13415	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HF888_RS13420	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HF888_RS13435	ENOG4105CHR	reductase
HF888_RS13440	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HF888_RS13450	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HF888_RS13455	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HF888_RS13460	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HF888_RS13465	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HF888_RS13480	ENOG4105E7A	Glutamine amidotransferase
HF888_RS13500	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HF888_RS13505	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF888_RS13510	ENOG4105CFG	Acts as a chaperone (By similarity)
HF888_RS13515	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF888_RS13520	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HF888_RS13525	ENOG41090R7	Ferric uptake
HF888_RS13530	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HF888_RS13535	ENOG4105VDB	UPF0125 protein
HF888_RS13540	ENOG4108Z1B	Cyclase dehydrase
HF888_RS13545	ENOG4105C8J	)-transporter
HF888_RS13550	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HF888_RS13575	ENOG4105DZ2	Transcriptional regulator
HF888_RS13615	ENOG4105BZU	Histidine kinase
HF888_RS13620	ENOG4105WH1	Two component transcriptional regulator luxr family
HF888_RS13635	ENOG41061ZR	Transcriptional regulator
HF888_RS13660	ENOG4107FQ9	ethanolamine ammonia-lyase
HF888_RS13665	ENOG4105CPD	ethanolamine ammonia-lyase
HF888_RS13675	ENOG4107QPN	acyl-Coa dehydrogenase
HF888_RS13685	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HF888_RS13690	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS13695	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF888_RS13700	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HF888_RS13705	ENOG4105EVH	UPF0753 protein
HF888_RS13710	ENOG4108TWJ	NADH dehydrogenase subunit 5
HF888_RS13715	ENOG4105DND	Transcriptional regulator
HF888_RS13735	ENOG4105C8P	)-transporter
HF888_RS13745	ENOG4108UQY	Iron-storage protein
HF888_RS13755	ENOG4108JEH	abc transporter atp-binding protein
HF888_RS13760	ENOG4106PMH	Extracellular solute-binding protein family 3
HF888_RS13765	ENOG4105DSP	amino acid AbC transporter
HF888_RS13770	ENOG4106YG3	ABC transporter
HF888_RS13785	ENOG4108MXF	Alpha Beta Hydrolase
HF888_RS13795	ENOG4105BZS	acriflavin resistance protein
HF888_RS13800	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HF888_RS13815	ENOG4105DQ4	alcohol dehydrogenase
HF888_RS13835	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HF888_RS13845	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
HF888_RS13850	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HF888_RS13855	ENOG4105CJP	fad dependent oxidoreductase
HF888_RS13860	ENOG4107T32	3-phytase (EC 3.1.3.8)
HF888_RS13865	ENOG4107RNH	Outer membrane receptor FepA
HF888_RS13880	ENOG4108ZX5	transcriptional regulator
HF888_RS13910	ENOG4105BZU	Histidine kinase
HF888_RS13915	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HF888_RS13920	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HF888_RS13930	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HF888_RS13935	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HF888_RS13945	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HF888_RS13960	ENOG4105EUB	pirin domain protein
HF888_RS13965	ENOG4105C2I	pirin domain protein
HF888_RS13985	ENOG4105EUJ	GTP cyclohydrolase i
HF888_RS13990	ENOG4105KKP	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase
HF888_RS14015	ENOG4105CZK	Aspartate kinase
HF888_RS14020	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
HF888_RS14050	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HF888_RS14060	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HF888_RS14085	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HF888_RS14095	ENOG4105K6V	RNA polymerase
HF888_RS14105	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HF888_RS14110	ENOG4105C7N	Xanthine uracil vitamin C permease
HF888_RS14115	ENOG4105D64	Mechanosensitive ion channel
HF888_RS14145	ENOG41082IR	Excinuclease ABC C subunit domain protein
HF888_RS14160	ENOG4105VRT	cytoplasmic protein
HF888_RS14165	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HF888_RS14190	ENOG4105DWT	malate dehydrogenase (quinone)
HF888_RS14205	ENOG4105CYM	Glutathione S-transferase
HF888_RS14220	ENOG4108ZAI	phosphatidylglycerophosphatase a
HF888_RS14245	ENOG4105C7B	Threonine dehydratase
HF888_RS14250	ENOG4105E66	phosphoriboisomerase A
HF888_RS14260	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HF888_RS14265	ENOG4105CQB	FAD linked oxidase domain protein
HF888_RS14270	ENOG4108JQ1	Dehydrogenase
HF888_RS14275	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HF888_RS14280	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HF888_RS14285	ENOG4105EHG	Permease protein
HF888_RS14290	ENOG4105E0A	ABC, transporter
HF888_RS14300	ENOG4108IQE	Amp-dependent synthetase and ligase
HF888_RS14320	ENOG4108NUU	Transcriptional regulator
HF888_RS14330	ENOG4108M1M	outer membrane lipoprotein-sorting protein
HF888_RS14345	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HF888_RS14350	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HF888_RS14355	ENOG4105VIE	preprotein translocase, subunit YajC
HF888_RS14360	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HF888_RS14365	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HF888_RS14390	ENOG4105BZ4	penicillin-binding protein
HF888_RS14400	ENOG4105WH1	Two component transcriptional regulator luxr family
HF888_RS14405	ENOG4105BZU	Histidine kinase
HF888_RS14425	ENOG4108K5H	permease YjgP YjgQ family protein
HF888_RS14430	ENOG4108M8S	permease YjgP YjgQ family protein
HF888_RS14435	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HF888_RS14450	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HF888_RS14465	ENOG4105MYG	DNA polymerase iii, chi subunit
HF888_RS14470	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HF888_RS14485	ENOG4105C09	Bile acid
HF888_RS14490	ENOG4105CHR	reductase
HF888_RS14495	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HF888_RS14500	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HF888_RS14505	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HF888_RS14510	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HF888_RS14520	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF888_RS14525	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HF888_RS14530	ENOG4108VZM	50s ribosomal protein L10
HF888_RS14535	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HF888_RS14540	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HF888_RS14545	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HF888_RS14550	ENOG4105PM1	preprotein translocase subunit SecE
HF888_RS14565	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HF888_RS14590	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HF888_RS14595	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HF888_RS14605	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HF888_RS14610	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
HF888_RS14620	ENOG4105EPW	hflc protein
HF888_RS14625	ENOG4107QJR	hflk protein
HF888_RS14630	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HF888_RS14635	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HF888_RS14645	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HF888_RS14650	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HF888_RS14655	ENOG4105K8N	protein family UPF0079, ATPase
HF888_RS14660	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HF888_RS14665	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HF888_RS14670	ENOG4108IJ7	Glycine betaine
HF888_RS14675	ENOG4108HQS	Glycine betaine
HF888_RS14680	ENOG4105GIJ	Glycine betaine
HF888_RS14700	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HF888_RS14705	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HF888_RS14710	ENOG4105DJ4	phosphatidylserine decarboxylase
HF888_RS14715	ENOG4105KHC	sulfurtransferase
HF888_RS14725	ENOG4107RD7	Flagellar Motor Protein, MotA
HF888_RS14730	ENOG4105ER2	Ompa motb domain protein
HF888_RS14740	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HF888_RS14745	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HF888_RS14755	ENOG4105ER2	Ompa motb domain protein
HF888_RS14760	ENOG4105E14	MotA TolQ exbB proton channel
HF888_RS14765	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HF888_RS14770	ENOG4105CTB	Polyprenyl synthetase
HF888_RS14775	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HF888_RS14805	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HF888_RS14830	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HF888_RS14865	ENOG41081FY	multiple antibiotic resistance (MarC)-related
HF888_RS14870	ENOG4105C1G	acyl-Coa dehydrogenase
HF888_RS14885	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HF888_RS14890	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HF888_RS14900	ENOG4105BZU	Histidine kinase
HF888_RS14910	ENOG4105C75	arginyL-tRNA synthetase
HF888_RS14925	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HF888_RS14930	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HF888_RS14945	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HF888_RS14965	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HF888_RS14970	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
HF888_RS14975	ENOG4107YU2	histidine triad (hIT) protein
HF888_RS14980	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HF888_RS14985	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HF888_RS14995	ENOG4105C8J	)-transporter
HF888_RS15005	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HF888_RS15010	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HF888_RS15015	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HF888_RS15020	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HF888_RS15030	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HF888_RS15035	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HF888_RS15055	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HF888_RS15075	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HF888_RS15080	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HF888_RS15100	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF888_RS15110	ENOG4108Z86	Glutamine amidotransferase
HF888_RS15120	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF888_RS15125	ENOG4105IPS	esterase
HF888_RS15130	ENOG4105DFG	type I secretion outer membrane protein
HF888_RS15135	ENOG41087AY	ADP-Ribose pyrophosphatase
HF888_RS15145	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HF888_RS15150	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HF888_RS15155	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HF888_RS15160	ENOG4105D1S	lipid A biosynthesis
HF888_RS15175	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HF888_RS15180	ENOG4105F0I	Aminotransferase
HF888_RS15185	ENOG4107NQ8	LysR family Transcriptional regulator
HF888_RS15210	ENOG4105CFM	UPF0317 protein
HF888_RS15215	ENOG4105BZG	amino acid carrier protein
HF888_RS15220	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HF888_RS15225	ENOG4105BZU	Histidine kinase
HF888_RS15230	ENOG4105C5H	ABC transporter
HF888_RS15240	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HF888_RS15245	ENOG4105DN9	Na H antiporter
HF888_RS15250	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HF888_RS15260	ENOG4105BZ8	glutamate synthase
HF888_RS15265	ENOG4105CBC	glutamate synthase
HF888_RS15275	ENOG4105D49	3-dehydroquinate synthase
HF888_RS15285	ENOG4105E4G	Type IV pilus
HF888_RS15310	ENOG4108JQC	penicillin-binding protein 1A
HF888_RS15320	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HF888_RS15325	ENOG4105CI3	gtp-binding protein typa
HF888_RS15330	ENOG4105C5F	glutamine synthetase
HF888_RS15340	ENOG4105CUX	Signal transduction histidine kinase
HF888_RS15345	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HF888_RS15385	ENOG4105D7Q	type ii secretion system
HF888_RS15390	ENOG4107QHF	type ii secretion system protein e
HF888_RS15395	ENOG4105GVR	general secretion pathway protein D
HF888_RS15440	ENOG4107RDB	Major Facilitator
HF888_RS15445	ENOG41086KC	Transcriptional regulator
HF888_RS15450	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HF888_RS15460	ENOG4105C94	Transporter
HF888_RS15470	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HF888_RS15475	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HF888_RS15490	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
HF888_RS15495	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HF888_RS15510	ENOG4105DY8	decarboxylase
HF888_RS15515	ENOG4105F1Y	L-lysine 6-monooxygenase (NADPH)
HF888_RS15525	ENOG4105DUU	IucA IucC family protein
HF888_RS15545	ENOG4105CDY	transcriptional regulatory protein
HF888_RS15560	ENOG4105DKW	ABC transporter
HF888_RS15565	ENOG4105BZU	Histidine kinase
HF888_RS15570	ENOG4105EEF	Alkane 1-monooxygenase
HF888_RS15575	ENOG4105M0Y	
HF888_RS15580	ENOG4108V0E	nucleoside 2-deoxyribosyltransferase YtoQ
HF888_RS15590	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HF888_RS15595	ENOG4105E0C	molybdate abc transporter
HF888_RS15600	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HF888_RS15610	ENOG4107QHF	type ii secretion system protein e
HF888_RS15615	ENOG4105I7R	Adenylate cyclase
HF888_RS15620	ENOG4107QZM	n-acetylglutamate synthase
HF888_RS15635	ENOG4105C01	Dihydroxy-acid dehydratase
HF888_RS15650	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF888_RS15655	ENOG4105C9A	Phoh family
HF888_RS15660	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HF888_RS15665	ENOG4108JU5	Magnesium and cobalt efflux protein
HF888_RS15680	ENOG41090Y2	cytochrome C
HF888_RS15685	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS15695	ENOG4105C8T	Leucyl-tRNA synthetase
HF888_RS15705	ENOG4105DJF	DNA polymerase III, delta' subunit
HF888_RS15720	ENOG4105CHF	Glutathione S-transferase
HF888_RS15725	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HF888_RS15730	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HF888_RS15735	ENOG4105D0A	hydroxylase
HF888_RS15740	ENOG4107RAQ	aminopeptidase
HF888_RS15765	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HF888_RS15770	ENOG4105BZU	Histidine kinase
HF888_RS15775	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HF888_RS15810	ENOG4105D2N	Aldolase
HF888_RS15815	ENOG4105BZA	Phosphoglycerate kinase
HF888_RS15830	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HF888_RS15835	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HF888_RS15845	ENOG41064RH	membrane protein YliF
HF888_RS15850	ENOG41067MG	lrgb family
HF888_RS15860	ENOG41060WC	Enoyl-CoA hydratase
HF888_RS15865	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HF888_RS15895	ENOG4108JJ8	(ABC) transporter
HF888_RS15900	ENOG4108JJ9	ABC, transporter
HF888_RS15905	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HF888_RS15910	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HF888_RS15915	ENOG4108VUY	thioesterase Superfamily protein
HF888_RS15920	ENOG4105D52	delta-aminolevulinic acid dehydratase
HF888_RS15925	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HF888_RS15930	ENOG4105C5H	ABC transporter
HF888_RS15960	ENOG4105PBF	Anti-RNA polymerase sigma 70 factor
HF888_RS15965	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HF888_RS15975	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
HF888_RS15980	ENOG4105D9M	gamma-glutamylcysteine synthetase
HF888_RS15985	ENOG4105BZM	domain protein
HF888_RS16005	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HF888_RS16015	ENOG4105BZU	Histidine kinase
HF888_RS16020	ENOG4105C8Q	Methyl-accepting chemotaxis
HF888_RS16025	ENOG4108ZGA	chew protein
HF888_RS16030	ENOG4105M3Z	response regulator
HF888_RS16035	ENOG4108UNF	response regulator
HF888_RS16040	ENOG4105D7Z	glutathione synthase
HF888_RS16050	ENOG4108UJU	UPF0301 protein
HF888_RS16055	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HF888_RS16060	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HF888_RS16065	ENOG4105CXT	aspartate transcarbamylase
HF888_RS16070	ENOG4105CD3	dihydroorotase
HF888_RS16090	ENOG4105CPT	Alpha beta hydrolase
HF888_RS16100	ENOG4108YZA	Nitrogen regulatory protein pii
HF888_RS16115	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
HF888_RS16120	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
HF888_RS16125	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
HF888_RS16130	ENOG4105CQM	Urea amidohydrolase subunit alpha
HF888_RS16135	ENOG4105KI2	Urea amidohydrolase subunit beta
HF888_RS16140	ENOG4108YZ9	Urea amidohydrolase subunit gamma
HF888_RS16145	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
HF888_RS16150	ENOG4108IV0	ABC, transporter
HF888_RS16155	ENOG4105C0Z	ABC transporter
HF888_RS16165	ENOG4105C32	Amino acid ABC transporter (Permease)
HF888_RS16180	ENOG4105W0Z	cytoplasmic protein
HF888_RS16185	ENOG4105C0P	Mg chelatase subunit ChlI
HF888_RS16190	ENOG4105DCF	alanine dehydrogenase
HF888_RS16195	ENOG4105EW9	transcriptional regulator AsnC family
HF888_RS16205	ENOG4105EW9	transcriptional regulator AsnC family
HF888_RS16215	ENOG4105DYB	Isoaspartyl dipeptidase
HF888_RS16220	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HF888_RS16225	ENOG4105D05	Receptor
HF888_RS16235	ENOG4105F4X	arginine
HF888_RS16240	ENOG4105C26	Dehydrogenase
HF888_RS16245	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
HF888_RS16250	ENOG4108IJ0	Aspartate ammonia-lyase
HF888_RS16255	ENOG4105CB2	alcohol dehydrogenase
HF888_RS16270	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HF888_RS16275	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HF888_RS16410	ENOG4107QMS	site-determining protein
HF888_RS16415	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)