locus-tag	class	description
HF888_RS00010	COG0210	DNA helicase
HF888_RS00015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HF888_RS00020	COG0450	alkyl hydroperoxide reductase
HF888_RS00025	COG4772	TonB-dependent receptor
HF888_RS00045	COG0501	Belongs to the peptidase M48B family
HF888_RS00075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HF888_RS00090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF888_RS00090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF888_RS00100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HF888_RS00105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HF888_RS00110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HF888_RS00115	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HF888_RS00120	COG1121	(ABC) transporter
HF888_RS00125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HF888_RS00135	COG0534	Mate efflux family protein
HF888_RS00145	COG1793	dna ligase
HF888_RS00150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HF888_RS00155	COG0339	signal peptide processing
HF888_RS00180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HF888_RS00185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HF888_RS00205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HF888_RS00210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HF888_RS00215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HF888_RS00220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HF888_RS00225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF888_RS00230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HF888_RS00240	COG0356	it plays a direct role in the translocation of protons across the membrane
HF888_RS00250	COG1475	DNA binding
HF888_RS00255	COG1192	Involved in chromosome partitioning
HF888_RS00265	COG0445	tRNA wobble uridine modification
HF888_RS00275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HF888_RS00280	COG0706	membrane insertase activity
HF888_RS00285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HF888_RS00290	COG0594	ribonuclease P activity
HF888_RS00295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HF888_RS00300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF888_RS00305	COG0592	DNA-directed DNA polymerase activity
HF888_RS00310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HF888_RS00330	COG0751	glycine-tRNA ligase activity
HF888_RS00335	COG0752	glycyl-tRNA synthetase alpha subunit
HF888_RS00345	COG0745	RESPONSE REGULATOR receiver
HF888_RS00350	COG1560	Kdo2-lipid A biosynthetic process
HF888_RS00355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HF888_RS00360	COG0569	domain protein
HF888_RS00365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HF888_RS00365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HF888_RS00370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HF888_RS00375	COG0242	peptide deformylase activity
HF888_RS00385	COG0758	DNA mediated transformation
HF888_RS00390	COG0009	L-threonylcarbamoyladenylate synthase
HF888_RS00395	COG0408	coproporphyrinogen oxidase activity
HF888_RS00400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HF888_RS00415	COG0210	DNA helicase
HF888_RS00425	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HF888_RS00445	COG1607	acyl-coa hydrolase
HF888_RS00450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HF888_RS00470	COG0573	inorganic phosphate transmembrane transporter activity
HF888_RS00475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HF888_RS00510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF888_RS00530	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HF888_RS00570	COG1301	dicarboxylic acid transport
HF888_RS00590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HF888_RS00595	COG0583	DNA-binding transcription factor activity
HF888_RS00605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF888_RS00615	COG3385	transposase activity
HF888_RS00625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HF888_RS00630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HF888_RS00635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HF888_RS00655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HF888_RS00670	COG1073	alpha beta
HF888_RS00680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF888_RS00680	COG4191	Histidine kinase
HF888_RS00685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HF888_RS00695	COG2363	Small membrane protein
HF888_RS00710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HF888_RS00725	COG2813	Specifically methylates the guanine in position
HF888_RS00725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HF888_RS00730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HF888_RS00740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HF888_RS00745	COG1561	YicC-like family, N-terminal region
HF888_RS00755	COG0194	GDP metabolic process
HF888_RS00760	COG1758	RNA polymerase activity
HF888_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HF888_RS00775	COG0165	Argininosuccinate lyase
HF888_RS00780	COG3275	phosphorelay sensor kinase activity
HF888_RS00790	COG0107	imidazoleglycerol-phosphate synthase activity
HF888_RS00795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HF888_RS00830	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HF888_RS00860	COG2203	Gaf domain
HF888_RS00860	COG4251	negative regulation of phosphorylation
HF888_RS00860	COG5001	Diguanylate cyclase
HF888_RS00860	COG3706	GGDEF domain
HF888_RS00870	COG2177	Part of the ABC transporter FtsEX involved in
HF888_RS00875	COG2884	Cell division ATP-binding protein ftsE
HF888_RS00880	COG0552	protein localization to endoplasmic reticulum
HF888_RS00890	COG0742	ribosomal rna small subunit methyltransferase
HF888_RS00915	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HF888_RS00920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HF888_RS00925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HF888_RS00935	COG1166	arginine decarboxylase activity
HF888_RS00950	COG0010	Belongs to the arginase family
HF888_RS00955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HF888_RS00965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HF888_RS00975	COG0784	Response regulator, receiver
HF888_RS00975	COG2205	protein histidine kinase activity
HF888_RS00975	COG5002	protein histidine kinase activity
HF888_RS01020	COG0579	oxidoreductase
HF888_RS01080	COG1595	DNA-templated transcription, initiation
HF888_RS01170	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HF888_RS01170	COG0662	Cupin 2, conserved barrel domain protein
HF888_RS01185	COG1309	transcriptional regulator
HF888_RS01190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HF888_RS01200	COG0756	dUTP diphosphatase activity
HF888_RS01205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HF888_RS01210	COG2003	Belongs to the UPF0758 family
HF888_RS01250	COG0300	oxidoreductase activity
HF888_RS01275	COG0248	Ppx GppA phosphatase
HF888_RS01280	COG2861	carbohydrate metabolic process
HF888_RS01285	COG0793	Belongs to the peptidase S41A family
HF888_RS01290	COG4942	peptidase
HF888_RS01295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HF888_RS01300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HF888_RS01305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HF888_RS01315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HF888_RS01330	COG0494	nUDIX hydrolase
HF888_RS01345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HF888_RS01355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HF888_RS01360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HF888_RS01365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HF888_RS01370	COG0640	Transcriptional regulator
HF888_RS01385	COG0494	nUDIX hydrolase
HF888_RS01390	COG1011	Hydrolase
HF888_RS01395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HF888_RS01405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HF888_RS01410	COG3108	Peptidase M15
HF888_RS01415	COG2989	Protein conserved in bacteria
HF888_RS01425	COG0730	response to heat
HF888_RS01435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HF888_RS01445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HF888_RS01450	COG5001	Diguanylate cyclase
HF888_RS01450	COG2203	Gaf domain
HF888_RS01450	COG4251	negative regulation of phosphorylation
HF888_RS01450	COG3706	GGDEF domain
HF888_RS01455	COG0589	response to stress
HF888_RS01460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HF888_RS01465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HF888_RS01470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HF888_RS01480	COG2176	DNA-directed DNA polymerase activity
HF888_RS01485	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HF888_RS01490	COG1473	amidohydrolase
HF888_RS01495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HF888_RS01500	COG0006	proline dipeptidase activity
HF888_RS01505	COG1012	belongs to the aldehyde dehydrogenase family
HF888_RS01515	COG2814	Major facilitator Superfamily
HF888_RS01530	COG4771	TonB-dependent receptor
HF888_RS01535	COG3842	ATPase activity
HF888_RS01540	COG1175	transmembrane transport
HF888_RS01545	COG1840	ABC-type Fe3 transport system, periplasmic component
HF888_RS01560	COG3830	Belongs to the UPF0237 family
HF888_RS01560	COG0560	Phosphoserine phosphatase
HF888_RS01565	COG3300	MHYT domain
HF888_RS01565	COG5001	Diguanylate cyclase
HF888_RS01570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HF888_RS01575	COG0254	rRNA binding
HF888_RS01580	COG0281	malic enzyme
HF888_RS01585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HF888_RS01610	COG0051	transcription antitermination factor activity, RNA binding
HF888_RS01615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HF888_RS01620	COG0088	Forms part of the polypeptide exit tunnel
HF888_RS01625	COG0089	rRNA binding
HF888_RS01630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF888_RS01635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HF888_RS01640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HF888_RS01645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HF888_RS01650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HF888_RS01655	COG0255	Belongs to the universal ribosomal protein uL29 family
HF888_RS01660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HF888_RS01665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HF888_RS01670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HF888_RS01675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HF888_RS01680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HF888_RS01685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HF888_RS01690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HF888_RS01695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HF888_RS01700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HF888_RS01705	COG1841	ribosomal large subunit assembly
HF888_RS01710	COG0200	Binds to the 23S rRNA
HF888_RS01720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HF888_RS01725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF888_RS01730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HF888_RS01735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HF888_RS01740	COG0202	RNA polymerase activity
HF888_RS01745	COG0203	ribosomal protein L17
HF888_RS01760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HF888_RS01765	COG0840	transmembrane signaling receptor activity
HF888_RS01775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HF888_RS01780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HF888_RS01790	COG0617	tRNA 3'-terminal CCA addition
HF888_RS01795	COG2204	response regulator
HF888_RS01800	COG4191	Histidine kinase
HF888_RS01815	COG0436	Aminotransferase
HF888_RS01820	COG1489	DNA binding
HF888_RS01835	COG0513	Belongs to the DEAD box helicase family
HF888_RS01855	COG0583	DNA-binding transcription factor activity
HF888_RS01865	COG0589	response to stress
HF888_RS01870	COG0659	secondary active sulfate transmembrane transporter activity
HF888_RS01875	COG0183	Belongs to the thiolase family
HF888_RS01895	COG2197	response regulator
HF888_RS01910	COG2067	long-chain fatty acid transport protein
HF888_RS01940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HF888_RS01950	COG0492	ferredoxin-NADP+ reductase activity
HF888_RS01955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF888_RS01965	COG0417	DNA replication proofreading
HF888_RS01985	COG0583	DNA-binding transcription factor activity
HF888_RS01990	COG0439	Biotin carboxylase
HF888_RS02010	COG0534	Mate efflux family protein
HF888_RS02015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HF888_RS02030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HF888_RS02045	COG0316	Belongs to the HesB IscA family
HF888_RS02050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HF888_RS02055	COG0739	heme binding
HF888_RS02060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HF888_RS02095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HF888_RS02095	COG1199	ATP-dependent helicase activity
HF888_RS02100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HF888_RS02100	COG0517	IMP dehydrogenase activity
HF888_RS02110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF888_RS02125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF888_RS02135	COG2205	protein histidine kinase activity
HF888_RS02135	COG0784	Response regulator, receiver
HF888_RS02135	COG2198	Histidine kinase
HF888_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS02150	COG1063	alcohol dehydrogenase
HF888_RS02175	COG1136	(ABC) transporter
HF888_RS02185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HF888_RS02210	COG1610	YqeY-like protein
HF888_RS02215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HF888_RS02220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HF888_RS02225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HF888_RS02230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HF888_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS02240	COG0617	tRNA 3'-terminal CCA addition
HF888_RS02265	COG2719	SpoVR family
HF888_RS02270	COG2718	Belongs to the UPF0229 family
HF888_RS02275	COG2766	serine protein kinase
HF888_RS02285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HF888_RS02295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HF888_RS02300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HF888_RS02305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF888_RS02310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HF888_RS02315	COG3178	'Phosphotransferase
HF888_RS02320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HF888_RS02325	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HF888_RS02330	COG0204	Acyl-transferase
HF888_RS02335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HF888_RS02340	COG0546	phosphoglycolate phosphatase activity
HF888_RS02345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HF888_RS02350	COG1960	acyl-CoA dehydrogenase activity
HF888_RS02380	COG2081	HI0933 family
HF888_RS02425	COG5001	Diguanylate cyclase
HF888_RS02425	COG4251	negative regulation of phosphorylation
HF888_RS02425	COG3706	GGDEF domain
HF888_RS02425	COG2203	Gaf domain
HF888_RS02435	COG0583	DNA-binding transcription factor activity
HF888_RS02440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HF888_RS02440	COG4651	solute:proton antiporter activity
HF888_RS02455	COG2200	EAL domain
HF888_RS02455	COG2771	luxR family
HF888_RS02480	COG0515	serine threonine protein kinase
HF888_RS02480	COG2815	serine threonine protein kinase
HF888_RS02485	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HF888_RS02490	COG2116	formate transmembrane transporter activity
HF888_RS02495	COG0012	GTP binding
HF888_RS02500	COG0193	aminoacyl-tRNA hydrolase activity
HF888_RS02505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HF888_RS02510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HF888_RS02520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HF888_RS02525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HF888_RS02535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HF888_RS02540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HF888_RS02545	COG2890	protein-(glutamine-N5) methyltransferase activity
HF888_RS02585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HF888_RS02595	COG3437	response regulator, receiver
HF888_RS02595	COG0784	Response regulator, receiver
HF888_RS02605	COG1765	OsmC-like protein
HF888_RS02615	COG0784	Response regulator, receiver
HF888_RS02615	COG5002	protein histidine kinase activity
HF888_RS02625	COG0138	bifunctional purine biosynthesis protein purh
HF888_RS02635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HF888_RS02645	COG2264	protein methyltransferase activity
HF888_RS02650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HF888_RS02695	COG3360	Dodecin
HF888_RS02720	COG1960	acyl-CoA dehydrogenase activity
HF888_RS02735	COG0514	ATP-dependent DNA helicase (RecQ)
HF888_RS02740	COG1671	Belongs to the UPF0178 family
HF888_RS02765	COG1024	Enoyl-CoA hydratase
HF888_RS02765	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF888_RS02770	COG0183	Belongs to the thiolase family
HF888_RS02790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HF888_RS02800	COG1183	phosphatidylcholine synthase activity
HF888_RS02805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HF888_RS02845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF888_RS02865	COG0519	Catalyzes the synthesis of GMP from XMP
HF888_RS02865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HF888_RS02870	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HF888_RS02885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HF888_RS02895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HF888_RS02925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HF888_RS02930	COG1116	anion transmembrane transporter activity
HF888_RS02935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HF888_RS02940	COG1116	anion transmembrane transporter activity
HF888_RS02940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HF888_RS02950	COG0243	molybdopterin cofactor binding
HF888_RS02955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HF888_RS02960	COG2146	nitrite reductase [NAD(P)H] activity
HF888_RS02965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HF888_RS02980	COG2223	nitrite transmembrane transporter activity
HF888_RS02985	COG2815	serine threonine protein kinase
HF888_RS02985	COG0515	serine threonine protein kinase
HF888_RS03005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HF888_RS03035	COG1104	cysteine desulfurase activity
HF888_RS03040	COG0719	Fe-S assembly protein
HF888_RS03045	COG0396	ATPase activity
HF888_RS03050	COG0719	Fe-S assembly protein
HF888_RS03055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HF888_RS03070	COG0318	PFAM AMP-dependent synthetase and ligase
HF888_RS03075	COG0133	tryptophan synthase activity
HF888_RS03080	COG2166	iron-sulfur cluster assembly
HF888_RS03085	COG0105	UTP biosynthetic process
HF888_RS03100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HF888_RS03105	COG0124	histidyl-tRNA synthetase
HF888_RS03110	COG2976	Protein conserved in bacteria
HF888_RS03120	COG1160	GTP binding
HF888_RS03135	COG4251	negative regulation of phosphorylation
HF888_RS03140	COG0784	Response regulator, receiver
HF888_RS03155	COG0840	transmembrane signaling receptor activity
HF888_RS03165	COG2840	Smr protein MutS2
HF888_RS03170	COG4942	peptidase
HF888_RS03175	COG1570	exodeoxyribonuclease VII activity
HF888_RS03190	COG2267	carboxylic ester hydrolase activity
HF888_RS03200	COG0519	Catalyzes the synthesis of GMP from XMP
HF888_RS03200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HF888_RS03210	COG0590	tRNA wobble adenosine to inosine editing
HF888_RS03215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HF888_RS03235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HF888_RS03240	COG2824	Alkylphosphonate utilization operon protein PhnA
HF888_RS03250	COG3040	lipid binding
HF888_RS03255	COG5001	Diguanylate cyclase
HF888_RS03255	COG3300	MHYT domain
HF888_RS03270	COG1136	(ABC) transporter
HF888_RS03275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HF888_RS03290	COG0175	sulfate reduction
HF888_RS03300	COG2945	thiolester hydrolase activity
HF888_RS03305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HF888_RS03310	COG0586	Pfam SNARE associated Golgi protein
HF888_RS03325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HF888_RS03330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HF888_RS03340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HF888_RS03345	COG0768	penicillin binding
HF888_RS03350	COG0772	Belongs to the SEDS family
HF888_RS03355	COG2951	lytic endotransglycosylase activity
HF888_RS03360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HF888_RS03365	COG1686	Belongs to the peptidase S11 family
HF888_RS03415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HF888_RS03420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HF888_RS03450	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HF888_RS03470	COG0268	Binds directly to 16S ribosomal RNA
HF888_RS03475	COG0728	peptidoglycan biosynthetic process
HF888_RS03480	COG0196	riboflavin kinase activity
HF888_RS03485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HF888_RS03490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HF888_RS03495	COG1047	Peptidyl-prolyl cis-trans
HF888_RS03505	COG1611	Belongs to the LOG family
HF888_RS03510	COG0517	IMP dehydrogenase activity
HF888_RS03510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HF888_RS03510	COG0617	tRNA 3'-terminal CCA addition
HF888_RS03520	COG0788	formyltetrahydrofolate deformylase activity
HF888_RS03545	COG3012	SEC-C Motif Domain Protein
HF888_RS03555	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HF888_RS03575	COG1546	Belongs to the CinA family
HF888_RS03580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HF888_RS03585	COG2137	regulation of response to DNA damage stimulus
HF888_RS03600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF888_RS03610	COG2010	Cytochrome c
HF888_RS03620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HF888_RS03625	COG0798	PFAM Bile acid sodium symporter
HF888_RS03630	COG0640	Transcriptional regulator
HF888_RS03635	COG1595	DNA-templated transcription, initiation
HF888_RS03660	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF888_RS03660	COG1024	Enoyl-CoA hydratase
HF888_RS03665	COG1960	acyl-CoA dehydrogenase activity
HF888_RS03670	COG1960	acyl-CoA dehydrogenase activity
HF888_RS03680	COG1320	monovalent cation:proton antiporter activity
HF888_RS03685	COG2212	antiporter activity
HF888_RS03695	COG0651	ATP synthesis coupled electron transport
HF888_RS03700	COG1006	Multisubunit Na H antiporter MnhC subunit
HF888_RS03705	COG2111	Na H antiporter
HF888_RS03705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HF888_RS03720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HF888_RS03725	COG4771	TonB-dependent receptor
HF888_RS03740	COG2249	NAD(P)H dehydrogenase (quinone) activity
HF888_RS03745	COG2207	Transcriptional regulator
HF888_RS03750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF888_RS03755	COG0154	amidase activity
HF888_RS03760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF888_RS03765	COG1077	Cell shape determining protein MreB Mrl
HF888_RS03770	COG1792	Involved in formation and maintenance of cell shape
HF888_RS03780	COG0424	maF-like protein
HF888_RS03785	COG1530	ribonuclease E activity
HF888_RS03795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HF888_RS03805	COG2239	Acts as a magnesium transporter
HF888_RS03810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HF888_RS03815	COG1660	Displays ATPase and GTPase activities
HF888_RS03830	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HF888_RS03835	COG1137	ATPase activity
HF888_RS03840	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HF888_RS03860	COG5007	Belongs to the BolA IbaG family
HF888_RS03865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HF888_RS03870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HF888_RS03875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HF888_RS03880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HF888_RS03885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF888_RS03950	COG0811	peptide transport
HF888_RS03995	COG0123	including yeast histone deacetylase and acetoin utilization protein
HF888_RS04020	COG1322	Protein conserved in bacteria
HF888_RS04035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HF888_RS04040	COG0315	cyclic pyranopterin monophosphate synthase activity
HF888_RS04045	COG0521	Mo-molybdopterin cofactor biosynthetic process
HF888_RS04060	COG2205	protein histidine kinase activity
HF888_RS04065	COG2197	response regulator
HF888_RS04070	COG0303	'Molybdopterin
HF888_RS04090	COG0840	transmembrane signaling receptor activity
HF888_RS04110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF888_RS04115	COG0513	Belongs to the DEAD box helicase family
HF888_RS04165	COG1944	ATP diphosphatase activity
HF888_RS04175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HF888_RS04175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HF888_RS04180	COG0228	four-way junction DNA binding
HF888_RS04185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HF888_RS04195	COG0335	large ribosomal subunit rRNA binding
HF888_RS04200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HF888_RS04210	COG0723	plastoquinol--plastocyanin reductase activity
HF888_RS04215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HF888_RS04220	COG2857	Cytochrome c1
HF888_RS04225	COG0625	glutathione transferase activity
HF888_RS04230	COG2969	positive regulation of protein catabolic process
HF888_RS04235	COG0583	DNA-binding transcription factor activity
HF888_RS04255	COG4771	TonB-dependent receptor
HF888_RS04275	COG1666	GTP binding
HF888_RS04310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HF888_RS04325	COG3031	protein transport across the cell outer membrane
HF888_RS04335	COG0424	maF-like protein
HF888_RS04375	COG3852	Histidine kinase
HF888_RS04385	COG2154	pterin-4-alpha-carbinolamine dehydratase
HF888_RS04410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HF888_RS04430	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HF888_RS04440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HF888_RS04445	COG0585	pseudouridine synthase activity
HF888_RS04450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HF888_RS04455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HF888_RS04475	COG0583	DNA-binding transcription factor activity
HF888_RS04480	COG2814	Major facilitator Superfamily
HF888_RS04485	COG0656	L-ascorbic acid biosynthetic process
HF888_RS04490	COG1309	transcriptional regulator
HF888_RS04510	COG1278	Cold shock
HF888_RS04520	COG4681	YaeQ
HF888_RS04525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF888_RS04545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HF888_RS04580	COG0811	peptide transport
HF888_RS04590	COG0848	biopolymer transport protein
HF888_RS04595	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HF888_RS04605	COG4172	Belongs to the ABC transporter superfamily
HF888_RS04610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HF888_RS04615	COG0601	transmembrane transport
HF888_RS04620	COG0747	negative chemotaxis
HF888_RS04665	COG1024	Enoyl-CoA hydratase
HF888_RS04665	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF888_RS04670	COG1960	acyl-CoA dehydrogenase activity
HF888_RS04675	COG2207	Transcriptional regulator
HF888_RS04685	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HF888_RS04700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF888_RS04705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HF888_RS04730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HF888_RS04740	COG2828	Protein conserved in bacteria
HF888_RS04745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HF888_RS04750	COG0372	Belongs to the citrate synthase family
HF888_RS04755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HF888_RS04760	COG1802	Transcriptional regulator
HF888_RS04770	COG0069	glutamate synthase activity
HF888_RS04775	COG4181	ATPase activity
HF888_RS04780	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HF888_RS04815	COG0137	argininosuccinate synthase activity
HF888_RS04830	COG4269	membrane
HF888_RS04840	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HF888_RS04875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF888_RS04880	COG0481	GTPase activity
HF888_RS04890	COG0571	ribonuclease III activity
HF888_RS04895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HF888_RS04900	COG1381	Involved in DNA repair and RecF pathway recombination
HF888_RS04905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HF888_RS04910	COG0736	holo-[acyl-carrier-protein] synthase activity
HF888_RS04925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HF888_RS04930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HF888_RS04935	COG3956	TIGRFAM MazG family protein
HF888_RS04940	COG0742	ribosomal rna small subunit methyltransferase
HF888_RS04950	COG1214	PFAM Peptidase M22, glycoprotease
HF888_RS04960	COG0563	adenylate kinase activity
HF888_RS04965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HF888_RS05015	COG2226	methyltransferase
HF888_RS05025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HF888_RS05055	COG2171	N-acyltransferase activity
HF888_RS05060	COG1393	Belongs to the ArsC family
HF888_RS05065	COG0436	Aminotransferase
HF888_RS05075	COG0024	Methionine aminopeptidase
HF888_RS05080	COG0052	Belongs to the universal ribosomal protein uS2 family
HF888_RS05085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HF888_RS05090	COG0528	UMP kinase activity
HF888_RS05095	COG0233	cytoplasmic translational termination
HF888_RS05100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HF888_RS05110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HF888_RS05135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF888_RS05140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HF888_RS05145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HF888_RS05170	COG0307	riboflavin synthase, alpha
HF888_RS05185	COG0545	Peptidyl-prolyl cis-trans isomerase
HF888_RS05210	COG1643	Atp-dependent helicase
HF888_RS05215	COG0840	transmembrane signaling receptor activity
HF888_RS05225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HF888_RS05230	COG1946	Acyl-CoA thioesterase
HF888_RS05345	COG1309	transcriptional regulator
HF888_RS05360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HF888_RS05370	COG4266	Belongs to the allantoicase family
HF888_RS05380	COG2351	hydroxyisourate hydrolase activity
HF888_RS05390	COG0402	S-adenosylhomocysteine deaminase activity
HF888_RS05410	COG4133	protoheme IX ABC transporter activity
HF888_RS05430	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HF888_RS05435	COG1138	Cytochrome C-type biogenesis protein
HF888_RS05445	COG3088	subunit of a heme lyase
HF888_RS05460	COG3123	guanosine phosphorylase activity
HF888_RS05465	COG0210	DNA helicase
HF888_RS05485	COG0084	hydrolase, TatD family'
HF888_RS05490	COG0259	pyridoxamine-phosphate oxidase activity
HF888_RS05505	COG1024	Enoyl-CoA hydratase
HF888_RS05510	COG1253	flavin adenine dinucleotide binding
HF888_RS05515	COG0602	queuosine metabolic process
HF888_RS05520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HF888_RS05540	COG4771	TonB-dependent receptor
HF888_RS05550	COG1858	cytochrome C peroxidase
HF888_RS05565	COG0848	biopolymer transport protein
HF888_RS05570	COG0811	peptide transport
HF888_RS05590	COG0583	DNA-binding transcription factor activity
HF888_RS05595	COG2259	Doxx family
HF888_RS05600	COG3384	dioxygenase
HF888_RS05615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HF888_RS05630	COG1215	transferase activity, transferring glycosyl groups
HF888_RS05645	COG0671	phosphoesterase, PA-phosphatase related
HF888_RS05665	COG1192	Involved in chromosome partitioning
HF888_RS05705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HF888_RS05710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF888_RS05720	COG1309	transcriptional regulator
HF888_RS05740	COG3038	cytochrome b561
HF888_RS05770	COG0745	RESPONSE REGULATOR receiver
HF888_RS05785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HF888_RS05795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF888_RS05815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HF888_RS05830	COG2022	thiamine diphosphate biosynthetic process
HF888_RS05835	COG0352	thiamine-phosphate diphosphorylase activity
HF888_RS05855	COG1573	uracil-dna glycosylase
HF888_RS05865	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HF888_RS05870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HF888_RS05875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HF888_RS05880	COG0632	four-way junction helicase activity
HF888_RS05885	COG2255	four-way junction helicase activity
HF888_RS05890	COG0824	Thioesterase
HF888_RS05910	COG0823	Involved in the tonB-independent uptake of proteins
HF888_RS05915	COG2885	chlorophyll binding
HF888_RS05935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HF888_RS05940	COG4783	chaperone-mediated protein folding
HF888_RS05945	COG0425	Belongs to the sulfur carrier protein TusA family
HF888_RS05955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF888_RS05965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HF888_RS05980	COG0545	Peptidyl-prolyl cis-trans isomerase
HF888_RS06005	COG0681	Belongs to the peptidase S26 family
HF888_RS06020	COG2205	protein histidine kinase activity
HF888_RS06020	COG0784	Response regulator, receiver
HF888_RS06020	COG5002	protein histidine kinase activity
HF888_RS06025	COG0778	Nitroreductase
HF888_RS06035	COG0741	lytic transglycosylase activity
HF888_RS06065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF888_RS06125	COG0318	PFAM AMP-dependent synthetase and ligase
HF888_RS06130	COG1643	Atp-dependent helicase
HF888_RS06140	COG3220	belongs to the UPF0276 family
HF888_RS06155	COG2853	Lipoprotein
HF888_RS06165	COG0745	RESPONSE REGULATOR receiver
HF888_RS06175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HF888_RS06195	COG2267	carboxylic ester hydrolase activity
HF888_RS06210	COG1607	acyl-coa hydrolase
HF888_RS06215	COG0564	pseudouridine synthase activity
HF888_RS06250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HF888_RS06255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HF888_RS06260	COG0705	Rhomboid family
HF888_RS06265	COG3139	Protein of unknown function (DUF1315)
HF888_RS06275	COG0308	aminopeptidase N
HF888_RS06285	COG4447	cellulose binding
HF888_RS06295	COG0564	pseudouridine synthase activity
HF888_RS06300	COG0183	Belongs to the thiolase family
HF888_RS06310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HF888_RS06330	COG2207	Transcriptional regulator
HF888_RS06330	COG4753	response regulator
HF888_RS06335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HF888_RS06340	COG0204	Acyl-transferase
HF888_RS06345	COG4067	protein conserved in archaea
HF888_RS06345	COG0189	ligase activity
HF888_RS06360	COG0189	ligase activity
HF888_RS06370	COG0583	DNA-binding transcription factor activity
HF888_RS06385	COG3437	response regulator, receiver
HF888_RS06385	COG4999	Histidine kinase
HF888_RS06385	COG3850	Histidine kinase
HF888_RS06385	COG2205	protein histidine kinase activity
HF888_RS06390	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF888_RS06390	COG1902	pentaerythritol trinitrate reductase activity
HF888_RS06400	COG0243	molybdopterin cofactor binding
HF888_RS06415	COG5001	Diguanylate cyclase
HF888_RS06415	COG3300	MHYT domain
HF888_RS06430	COG0431	NADPH-dependent FMN reductase
HF888_RS06445	COG3706	GGDEF domain
HF888_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS06465	COG0402	S-adenosylhomocysteine deaminase activity
HF888_RS06480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HF888_RS06490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HF888_RS06495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HF888_RS06500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HF888_RS06510	COG3562	capsule polysaccharide
HF888_RS06530	COG0776	regulation of translation
HF888_RS06535	COG0166	Belongs to the GPI family
HF888_RS06540	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HF888_RS06545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HF888_RS06550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HF888_RS06555	COG1088	dTDP-glucose 4,6-dehydratase activity
HF888_RS06570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HF888_RS06620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HF888_RS06635	COG0436	Aminotransferase
HF888_RS06640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HF888_RS06645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HF888_RS06650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HF888_RS06655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HF888_RS06660	COG2832	Protein of unknown function (DUF454)
HF888_RS06670	COG0745	RESPONSE REGULATOR receiver
HF888_RS06690	COG3122	Protein conserved in bacteria
HF888_RS06705	COG0271	Belongs to the BolA IbaG family
HF888_RS06745	COG2207	Transcriptional regulator
HF888_RS06750	COG1022	Amp-dependent synthetase and ligase
HF888_RS06755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF888_RS06780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF888_RS06790	COG1187	pseudouridine synthase activity
HF888_RS06795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HF888_RS06800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF888_RS06835	COG2801	Transposase and inactivated derivatives
HF888_RS06850	COG3047	cAMP biosynthetic process
HF888_RS06855	COG1309	transcriptional regulator
HF888_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS06865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF888_RS06870	COG1960	acyl-CoA dehydrogenase activity
HF888_RS06875	COG1024	Enoyl-CoA hydratase
HF888_RS06885	COG1960	acyl-CoA dehydrogenase activity
HF888_RS06900	COG0439	Biotin carboxylase
HF888_RS06915	COG1116	anion transmembrane transporter activity
HF888_RS06915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HF888_RS06920	COG2011	ABC-type metal ion transport system permease component
HF888_RS06930	COG0583	DNA-binding transcription factor activity
HF888_RS06940	COG1942	4-Oxalocrotonate Tautomerase
HF888_RS06945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HF888_RS06950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HF888_RS06960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF888_RS06965	COG0215	cysteine-tRNA ligase activity
HF888_RS06970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HF888_RS06970	COG4651	solute:proton antiporter activity
HF888_RS06980	COG4774	siderophore transport
HF888_RS06980	COG1629	transport
HF888_RS06995	COG0784	Response regulator, receiver
HF888_RS06995	COG2205	protein histidine kinase activity
HF888_RS07000	COG0733	neurotransmitter:sodium symporter activity
HF888_RS07015	COG0326	Molecular chaperone. Has ATPase activity
HF888_RS07060	COG1309	transcriptional regulator
HF888_RS07065	COG1376	ErfK ybiS ycfS ynhG family protein
HF888_RS07070	COG1472	Belongs to the glycosyl hydrolase 3 family
HF888_RS07075	COG0668	transmembrane transport
HF888_RS07090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HF888_RS07100	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HF888_RS07105	COG1805	sodium ion transport
HF888_RS07115	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HF888_RS07120	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HF888_RS07125	COG2871	sodium ion transport
HF888_RS07305	COG0432	Pfam Uncharacterised protein family UPF0047
HF888_RS07315	COG1739	Uncharacterized protein family UPF0029
HF888_RS07320	COG2813	Specifically methylates the guanine in position
HF888_RS07340	COG1477	protein flavinylation
HF888_RS07350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF888_RS07365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HF888_RS07370	COG0584	glycerophosphoryl diester phosphodiesterase
HF888_RS07385	COG3022	response to hydroperoxide
HF888_RS07410	COG0439	Biotin carboxylase
HF888_RS07430	COG4591	ABC-type transport system involved in lipoprotein release permease component
HF888_RS07435	COG1136	(ABC) transporter
HF888_RS07445	COG0658	competence protein
HF888_RS07445	COG2333	competence protein COMEC
HF888_RS07450	COG0811	peptide transport
HF888_RS07455	COG0848	biopolymer transport protein
HF888_RS07460	COG1132	(ABC) transporter
HF888_RS07470	COG2835	tetraacyldisaccharide 4'-kinase activity
HF888_RS07475	COG4942	peptidase
HF888_RS07480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HF888_RS07485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HF888_RS07490	COG1530	ribonuclease E activity
HF888_RS07510	COG1399	metal-binding, possibly nucleic acid-binding protein
HF888_RS07515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HF888_RS07520	COG0416	fatty acid biosynthetic process
HF888_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS07535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HF888_RS07540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HF888_RS07545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HF888_RS07550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HF888_RS07555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HF888_RS07570	COG2205	protein histidine kinase activity
HF888_RS07570	COG0784	Response regulator, receiver
HF888_RS07580	COG0277	FAD linked oxidase domain protein
HF888_RS07585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HF888_RS07590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HF888_RS07615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HF888_RS07620	COG0835	chemotaxis
HF888_RS07620	COG0784	Response regulator, receiver
HF888_RS07625	COG3217	Mosc domain protein beta barrel domain protein
HF888_RS07625	COG0633	Ferredoxin
HF888_RS07655	COG1250	3-hydroxyacyl-CoA dehydrogenase
HF888_RS07655	COG1024	Enoyl-CoA hydratase
HF888_RS07660	COG0183	Belongs to the thiolase family
HF888_RS07685	COG0123	including yeast histone deacetylase and acetoin utilization protein
HF888_RS07690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HF888_RS07690	COG1042	CoA-binding domain protein
HF888_RS07690	COG0045	succinate-CoA ligase (ADP-forming) activity
HF888_RS07820	COG2153	protein acetylation
HF888_RS07825	COG2850	peptidyl-arginine hydroxylation
HF888_RS07835	COG3083	sulfuric ester hydrolase activity
HF888_RS07840	COG2915	High frequency lysogenization protein hflD homolog
HF888_RS07855	COG1187	pseudouridine synthase activity
HF888_RS07865	COG1278	Cold shock
HF888_RS07870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HF888_RS07875	COG0542	response to heat
HF888_RS07880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HF888_RS07885	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HF888_RS07890	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HF888_RS07895	COG1674	ftsk spoiiie
HF888_RS07900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HF888_RS07905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HF888_RS07910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HF888_RS07915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HF888_RS07920	COG1648	precorrin-2 dehydrogenase activity
HF888_RS07920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HF888_RS07925	COG0840	transmembrane signaling receptor activity
HF888_RS07945	COG0811	peptide transport
HF888_RS07950	COG0811	peptide transport
HF888_RS07955	COG0848	biopolymer transport protein
HF888_RS07970	COG0708	Exodeoxyribonuclease III
HF888_RS07980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HF888_RS07980	COG0301	tRNA thio-modification
HF888_RS07985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HF888_RS07995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF888_RS08020	COG4585	Histidine kinase
HF888_RS08035	COG0587	DNA-directed DNA polymerase activity
HF888_RS08080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HF888_RS08085	COG3313	Fe-S protein
HF888_RS08105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HF888_RS08140	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HF888_RS08205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HF888_RS08225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HF888_RS08285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HF888_RS08290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HF888_RS08300	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HF888_RS08300	COG0316	Belongs to the HesB IscA family
HF888_RS08305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HF888_RS08320	COG0604	alcohol dehydrogenase
HF888_RS08325	COG0616	signal peptide processing
HF888_RS08345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HF888_RS08350	COG0328	RNA-DNA hybrid ribonuclease activity
HF888_RS08355	COG2226	methyltransferase
HF888_RS08360	COG1388	LysM domain
HF888_RS08360	COG0741	lytic transglycosylase activity
HF888_RS08365	COG4166	transmembrane transport
HF888_RS08375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF888_RS08385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HF888_RS08390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HF888_RS08395	COG0740	serine-type endopeptidase activity
HF888_RS08400	COG0544	peptidyl-prolyl cis-trans isomerase activity
HF888_RS08410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HF888_RS08415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HF888_RS08420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF888_RS08445	COG4251	negative regulation of phosphorylation
HF888_RS08445	COG2203	Gaf domain
HF888_RS08445	COG5001	Diguanylate cyclase
HF888_RS08445	COG3706	GGDEF domain
HF888_RS08455	COG0625	glutathione transferase activity
HF888_RS08460	COG1199	ATP-dependent helicase activity
HF888_RS08470	COG3409	Peptidoglycan-binding domain 1 protein
HF888_RS08470	COG3267	Type II secretory pathway component ExeA
HF888_RS08505	COG0670	Belongs to the BI1 family
HF888_RS08510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HF888_RS08515	COG2923	Belongs to the DsrF TusC family
HF888_RS08530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HF888_RS08550	COG0442	prolyl-tRNA aminoacylation
HF888_RS08555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HF888_RS08570	COG1295	ribonuclease BN
HF888_RS08575	COG1393	Belongs to the ArsC family
HF888_RS08600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF888_RS08605	COG0628	permease
HF888_RS08610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HF888_RS08620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HF888_RS08625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HF888_RS08670	COG3706	GGDEF domain
HF888_RS08680	COG1280	lysine exporter protein (LysE YggA)
HF888_RS08685	COG0717	Belongs to the dCTP deaminase family
HF888_RS08690	COG1444	tRNA N-acetyltransferase activity
HF888_RS08695	COG0489	protein tyrosine kinase activity
HF888_RS08705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF888_RS08705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF888_RS08715	COG4657	Part of a membrane complex involved in electron transport
HF888_RS08720	COG2878	Part of a membrane complex involved in electron transport
HF888_RS08730	COG4658	electron transport chain
HF888_RS08735	COG4659	FMN binding
HF888_RS08740	COG4660	Part of a membrane complex involved in electron transport
HF888_RS08745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HF888_RS08750	COG0346	lactoylglutathione lyase activity
HF888_RS08755	COG1469	GTP cyclohydrolase I activity
HF888_RS08765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HF888_RS08790	COG1410	methionine synthase
HF888_RS08790	COG0646	methionine synthase
HF888_RS08795	COG0646	methionine synthase
HF888_RS08795	COG1410	methionine synthase
HF888_RS08820	COG0596	Alpha beta hydrolase
HF888_RS08825	COG0653	protein targeting
HF888_RS08840	COG0778	Nitroreductase
HF888_RS08855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HF888_RS08860	COG2226	methyltransferase
HF888_RS08875	COG0714	Associated with various cellular activities
HF888_RS08890	COG1286	toxin biosynthetic process
HF888_RS08900	COG0285	dihydrofolate synthase activity
HF888_RS08905	COG0159	tryptophan synthase activity
HF888_RS08915	COG0135	phosphoribosylanthranilate isomerase activity
HF888_RS08920	COG0101	tRNA pseudouridine synthase activity
HF888_RS08930	COG0488	(ABC) transporter
HF888_RS08935	COG3264	Mechanosensitive ion channel
HF888_RS08935	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HF888_RS08940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HF888_RS08945	COG0473	3-isopropylmalate dehydrogenase activity
HF888_RS08950	COG0066	3-isopropylmalate dehydratase activity
HF888_RS08955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HF888_RS08965	COG0589	response to stress
HF888_RS08985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HF888_RS08990	COG0840	transmembrane signaling receptor activity
HF888_RS09010	COG0385	Bile acid
HF888_RS09030	COG0697	spore germination
HF888_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
HF888_RS09075	COG0513	Belongs to the DEAD box helicase family
HF888_RS09110	COG1764	response to oxidative stress
HF888_RS09115	COG1742	UPF0060 membrane protein
HF888_RS09175	COG0045	succinate-CoA ligase (ADP-forming) activity
HF888_RS09195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HF888_RS09200	COG1053	succinate dehydrogenase
HF888_RS09205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HF888_RS09210	COG2009	succinate dehydrogenase
HF888_RS09220	COG2084	Dehydrogenase
HF888_RS09245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HF888_RS09255	COG2814	Major facilitator Superfamily
HF888_RS09260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HF888_RS09265	COG2890	protein-(glutamine-N5) methyltransferase activity
HF888_RS09310	COG1067	ATP-dependent peptidase activity
HF888_RS09315	COG0784	Response regulator, receiver
HF888_RS09315	COG2205	protein histidine kinase activity
HF888_RS09350	COG0842	Transport permease protein
HF888_RS09355	COG1131	(ABC) transporter
HF888_RS09390	COG1846	Transcriptional regulator
HF888_RS09395	COG0386	Belongs to the glutathione peroxidase family
HF888_RS09405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HF888_RS09410	COG0436	Aminotransferase
HF888_RS09420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HF888_RS09420	COG0116	Belongs to the methyltransferase superfamily
HF888_RS09430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HF888_RS09435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF888_RS09435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF888_RS09450	COG3101	peptidyl-lysine hydroxylation
HF888_RS09455	COG0534	Mate efflux family protein
HF888_RS09465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HF888_RS09490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HF888_RS09525	COG2010	Cytochrome c
HF888_RS09525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HF888_RS09555	COG2801	Transposase and inactivated derivatives
HF888_RS09615	COG1942	4-Oxalocrotonate Tautomerase
HF888_RS09635	COG0667	Aldo Keto reductase
HF888_RS09655	COG1720	tRNA m6t6A37 methyltransferase activity
HF888_RS09665	COG4191	Histidine kinase
HF888_RS09665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF888_RS09685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HF888_RS09690	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HF888_RS09700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF888_RS09715	COG3278	Belongs to the heme-copper respiratory oxidase family
HF888_RS09730	COG2010	Cytochrome c
HF888_RS09745	COG2217	Heavy metal translocating P-type atpase
HF888_RS09760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HF888_RS09770	COG0037	tRNA processing
HF888_RS09780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HF888_RS09790	COG0484	heat shock protein binding
HF888_RS09805	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS09830	COG0583	DNA-binding transcription factor activity
HF888_RS09845	COG0252	asparaginase activity
HF888_RS09865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HF888_RS09880	COG3706	GGDEF domain
HF888_RS09890	COG0004	ammonium transporteR
HF888_RS09900	COG3130	regulation of translation
HF888_RS09905	COG0167	dihydroorotate dehydrogenase activity
HF888_RS09920	COG0714	Associated with various cellular activities
HF888_RS09940	COG2304	oxidoreductase activity
HF888_RS09960	COG1703	isobutyryl-CoA mutase activity
HF888_RS09960	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF888_RS09960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF888_RS09965	COG1278	Cold shock
HF888_RS09970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HF888_RS09980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HF888_RS09990	COG0640	Transcriptional regulator
HF888_RS09995	COG0659	secondary active sulfate transmembrane transporter activity
HF888_RS10030	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF888_RS10030	COG1902	pentaerythritol trinitrate reductase activity
HF888_RS10070	COG1555	photosystem II stabilization
HF888_RS10080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HF888_RS10090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF888_RS10095	COG5265	(ABC) transporter
HF888_RS10105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HF888_RS10110	COG2885	chlorophyll binding
HF888_RS10115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HF888_RS10120	COG2391	methyltransferase activity
HF888_RS10130	COG0450	alkyl hydroperoxide reductase
HF888_RS10145	COG0824	Thioesterase
HF888_RS10155	COG0776	regulation of translation
HF888_RS10160	COG0072	phenylalanine-tRNA ligase activity
HF888_RS10165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HF888_RS10170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HF888_RS10175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HF888_RS10180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HF888_RS10215	COG3210	domain, Protein
HF888_RS10215	COG3210	domain, Protein
HF888_RS10220	COG2831	hemolysin activation secretion protein
HF888_RS10245	COG0583	DNA-binding transcription factor activity
HF888_RS10250	COG2130	NADP-dependent
HF888_RS10260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HF888_RS10265	COG1049	propionate catabolic process, 2-methylcitrate cycle
HF888_RS10285	COG0604	alcohol dehydrogenase
HF888_RS10290	COG1132	(ABC) transporter
HF888_RS10300	COG0783	Belongs to the Dps family
HF888_RS10305	COG1132	(ABC) transporter
HF888_RS10310	COG0583	DNA-binding transcription factor activity
HF888_RS10315	COG2205	protein histidine kinase activity
HF888_RS10320	COG0745	RESPONSE REGULATOR receiver
HF888_RS10325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF888_RS10330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF888_RS10335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HF888_RS10340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF888_RS10350	COG4716	Myosin-crossreactive antigen
HF888_RS10360	COG1283	sodium-dependent phosphate transmembrane transporter activity
HF888_RS10375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HF888_RS10380	COG0840	transmembrane signaling receptor activity
HF888_RS10400	COG1741	Belongs to the pirin family
HF888_RS10410	COG0010	Belongs to the arginase family
HF888_RS10415	COG0583	DNA-binding transcription factor activity
HF888_RS10430	COG0348	domain, Protein
HF888_RS10445	COG0204	Acyl-transferase
HF888_RS10450	COG3706	GGDEF domain
HF888_RS10455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF888_RS10475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF888_RS10485	COG1012	belongs to the aldehyde dehydrogenase family
HF888_RS10505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF888_RS10545	COG0583	DNA-binding transcription factor activity
HF888_RS10575	COG3339	Conserved Protein
HF888_RS10660	COG2801	Transposase and inactivated derivatives
HF888_RS10680	COG1942	4-Oxalocrotonate Tautomerase
HF888_RS10710	COG0583	DNA-binding transcription factor activity
HF888_RS10720	COG0800	Aldolase
HF888_RS10730	COG0174	glutamine synthetase
HF888_RS10750	COG3842	ATPase activity
HF888_RS10755	COG1176	ABC-type spermidine putrescine transport system, permease component I
HF888_RS10760	COG1177	transmembrane transport
HF888_RS10770	COG3145	DNA-N1-methyladenine dioxygenase activity
HF888_RS10805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HF888_RS10810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HF888_RS10815	COG0180	Tryptophanyl-tRNA synthetase
HF888_RS10820	COG0009	L-threonylcarbamoyladenylate synthase
HF888_RS10825	COG0613	PHP domain protein
HF888_RS10835	COG2350	Protein conserved in bacteria
HF888_RS10840	COG4991	sh3 domain protein
HF888_RS10855	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HF888_RS10855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF888_RS10890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF888_RS10895	COG3115	cell septum assembly
HF888_RS10930	COG2161	toxin-antitoxin pair type II binding
HF888_RS10940	COG0071	Belongs to the small heat shock protein (HSP20) family
HF888_RS10945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF888_RS10960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF888_RS10985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HF888_RS11000	COG1012	belongs to the aldehyde dehydrogenase family
HF888_RS11000	COG1454	alcohol dehydrogenase
HF888_RS11020	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HF888_RS11025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HF888_RS11040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HF888_RS11045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HF888_RS11050	COG4106	trans-aconitate 2-methyltransferase activity
HF888_RS11075	COG0318	PFAM AMP-dependent synthetase and ligase
HF888_RS11085	COG0789	Transcriptional regulator
HF888_RS11090	COG1960	acyl-CoA dehydrogenase activity
HF888_RS11095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF888_RS11100	COG1024	Enoyl-CoA hydratase
HF888_RS11105	COG4770	biotin carboxylase activity
HF888_RS11140	COG1254	Belongs to the acylphosphatase family
HF888_RS11175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HF888_RS11195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HF888_RS11210	COG2983	Belongs to the UPF0260 family
HF888_RS11215	COG3100	YcgL domain-containing protein
HF888_RS11225	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HF888_RS11230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HF888_RS11245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HF888_RS11250	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HF888_RS11265	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS11300	COG0023	Translation Initiation Factor
HF888_RS11310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HF888_RS11320	COG0204	Acyl-transferase
HF888_RS11330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HF888_RS11370	COG1025	Belongs to the peptidase M16 family
HF888_RS11385	COG5507	3-demethylubiquinone-9 3-methyltransferase
HF888_RS11400	COG3540	Alkaline phosphatase
HF888_RS11415	COG3246	L-lysine catabolic process to acetate
HF888_RS11420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HF888_RS11445	COG0450	alkyl hydroperoxide reductase
HF888_RS11460	COG0516	GMP reductase activity
HF888_RS11460	COG0517	IMP dehydrogenase activity
HF888_RS11500	COG2925	Exonuclease
HF888_RS11545	COG0746	molybdenum cofactor guanylyltransferase activity
HF888_RS11550	COG1272	protein, Hemolysin III
HF888_RS11560	COG0288	reversible hydration of carbon dioxide
HF888_RS11565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HF888_RS11575	COG0557	exoribonuclease II activity
HF888_RS11585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HF888_RS11605	COG0583	DNA-binding transcription factor activity
HF888_RS11615	COG2264	protein methyltransferase activity
HF888_RS11620	COG0741	lytic transglycosylase activity
HF888_RS11630	COG0084	hydrolase, TatD family'
HF888_RS11640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HF888_RS11650	COG4807	Protein conserved in bacteria
HF888_RS11660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HF888_RS11665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HF888_RS11670	COG1074	ATP-dependent DNA helicase activity
HF888_RS11675	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HF888_RS11705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HF888_RS11710	COG0509	glycine decarboxylation via glycine cleavage system
HF888_RS11720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF888_RS11720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF888_RS11730	COG3549	Plasmid maintenance system killer
HF888_RS11745	COG0583	DNA-binding transcription factor activity
HF888_RS11755	COG1902	pentaerythritol trinitrate reductase activity
HF888_RS11760	COG1162	GTPase activity
HF888_RS11775	COG0583	DNA-binding transcription factor activity
HF888_RS11800	COG0835	chemotaxis
HF888_RS11815	COG1192	Involved in chromosome partitioning
HF888_RS11820	COG1360	Flagellar Motor Protein
HF888_RS11825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HF888_RS11830	COG2201	protein-glutamate methylesterase activity
HF888_RS11835	COG2198	Histidine kinase
HF888_RS11835	COG0784	Response regulator, receiver
HF888_RS11835	COG0643	Histidine kinase
HF888_RS11840	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HF888_RS11875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HF888_RS11885	COG1987	bacterial-type flagellum assembly
HF888_RS11935	COG2201	protein-glutamate methylesterase activity
HF888_RS11940	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HF888_RS11950	COG0840	transmembrane signaling receptor activity
HF888_RS11955	COG0835	chemotaxis
HF888_RS11960	COG2198	Histidine kinase
HF888_RS11960	COG0643	Histidine kinase
HF888_RS11965	COG0745	RESPONSE REGULATOR receiver
HF888_RS12000	COG1677	Flagellar hook-basal body complex protein FliE
HF888_RS12060	COG0107	imidazoleglycerol-phosphate synthase activity
HF888_RS12065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HF888_RS12070	COG2089	acid synthase
HF888_RS12085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HF888_RS12090	COG1086	Polysaccharide biosynthesis protein
HF888_RS12095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HF888_RS12100	COG1256	bacterial-type flagellum assembly
HF888_RS12100	COG4786	Flagellar basal body rod
HF888_RS12115	COG1706	bacterial-type flagellum-dependent cell motility
HF888_RS12120	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HF888_RS12130	COG4787	bacterial-type flagellum-dependent cell motility
HF888_RS12140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HF888_RS12150	COG1815	bacterial-type flagellum-dependent cell motility
HF888_RS12155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HF888_RS12160	COG0835	chemotaxis
HF888_RS12160	COG0784	Response regulator, receiver
HF888_RS12190	COG0463	Glycosyl transferase, family 2
HF888_RS12210	COG0454	-acetyltransferase
HF888_RS12305	COG3273	potassium ion transport
HF888_RS12305	COG0471	metal ion transport
HF888_RS12340	COG3268	Saccharopine dehydrogenase
HF888_RS12360	COG1047	Peptidyl-prolyl cis-trans
HF888_RS12365	COG4221	oxidoreductase activity
HF888_RS12375	COG4335	DNA alkylation repair
HF888_RS12380	COG3622	Belongs to the hyi family
HF888_RS12390	COG1639	'signal transduction protein
HF888_RS12395	COG2814	Major facilitator Superfamily
HF888_RS12415	COG0028	Belongs to the TPP enzyme family
HF888_RS12440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HF888_RS12450	COG4536	flavin adenine dinucleotide binding
HF888_RS12490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HF888_RS12490	COG3323	Protein of unknown function (DUF1653)
HF888_RS12530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HF888_RS12565	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HF888_RS12575	COG3630	sodium ion export across plasma membrane
HF888_RS12580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HF888_RS12585	COG3852	Histidine kinase
HF888_RS12600	COG2204	response regulator
HF888_RS12605	COG1492	cobalamin metabolic process
HF888_RS12615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HF888_RS12645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HF888_RS12650	COG0527	aspartate kinase activity
HF888_RS12655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HF888_RS12680	COG1252	NADH dehydrogenase
HF888_RS12695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HF888_RS12700	COG2226	methyltransferase
HF888_RS12705	COG1073	alpha beta
HF888_RS12705	COG2226	methyltransferase
HF888_RS12710	COG0156	8-amino-7-oxononanoate synthase activity
HF888_RS12715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HF888_RS12720	COG1040	competence protein
HF888_RS12725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HF888_RS12750	COG3138	arginine N-succinyltransferase
HF888_RS12755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HF888_RS12760	COG1522	sequence-specific DNA binding
HF888_RS12770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HF888_RS12775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF888_RS12780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HF888_RS12785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HF888_RS12790	COG0142	geranyltranstransferase activity
HF888_RS12815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HF888_RS12820	COG0360	Binds together with S18 to 16S ribosomal RNA
HF888_RS12835	COG3038	cytochrome b561
HF888_RS12840	COG2353	YceI-like domain
HF888_RS12850	COG0385	Bile acid
HF888_RS12860	COG1185	polyribonucleotide nucleotidyltransferase activity
HF888_RS12865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HF888_RS12870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HF888_RS12875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HF888_RS12880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HF888_RS12885	COG2251	uridine kinase activity
HF888_RS12885	COG0195	Participates in both transcription termination and antitermination
HF888_RS12890	COG0779	Required for maturation of 30S ribosomal subunits
HF888_RS12910	COG0149	triose-phosphate isomerase activity
HF888_RS12935	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF888_RS12945	COG0406	alpha-ribazole phosphatase activity
HF888_RS12950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HF888_RS12965	COG1940	carbohydrate kinase activity
HF888_RS12975	COG3023	N-Acetylmuramoyl-L-alanine amidase
HF888_RS13010	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HF888_RS13015	COG0237	dephospho-CoA kinase activity
HF888_RS13025	COG0494	nUDIX hydrolase
HF888_RS13035	COG0653	protein targeting
HF888_RS13040	COG0739	heme binding
HF888_RS13045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HF888_RS13060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HF888_RS13065	COG1181	Belongs to the D-alanine--D-alanine ligase family
HF888_RS13070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HF888_RS13075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HF888_RS13080	COG0772	Belongs to the SEDS family
HF888_RS13085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HF888_RS13090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HF888_RS13095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HF888_RS13100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HF888_RS13115	COG0275	rRNA processing
HF888_RS13120	COG2001	Belongs to the MraZ family
HF888_RS13130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HF888_RS13135	COG3107	peptidoglycan biosynthetic process
HF888_RS13160	COG0047	phosphoribosylformylglycinamidine synthase activity
HF888_RS13160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HF888_RS13165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HF888_RS13190	COG0513	Belongs to the DEAD box helicase family
HF888_RS13195	COG0037	tRNA processing
HF888_RS13215	COG0745	RESPONSE REGULATOR receiver
HF888_RS13220	COG2205	protein histidine kinase activity
HF888_RS13275	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HF888_RS13290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HF888_RS13340	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HF888_RS13350	COG2264	protein methyltransferase activity
HF888_RS13360	COG5380	lipid catabolic process
HF888_RS13365	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HF888_RS13370	COG1960	acyl-CoA dehydrogenase activity
HF888_RS13390	COG1607	acyl-coa hydrolase
HF888_RS13395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HF888_RS13400	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS13415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HF888_RS13420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HF888_RS13435	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS13440	COG0736	holo-[acyl-carrier-protein] synthase activity
HF888_RS13450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HF888_RS13460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HF888_RS13465	COG0505	Belongs to the CarA family
HF888_RS13480	COG0121	glutamine amidotransferase
HF888_RS13500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HF888_RS13505	COG0484	heat shock protein binding
HF888_RS13510	COG0443	Heat shock 70 kDa protein
HF888_RS13515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF888_RS13520	COG0497	DNA recombination
HF888_RS13535	COG2914	Belongs to the UPF0125 (RnfH) family
HF888_RS13545	COG0733	neurotransmitter:sodium symporter activity
HF888_RS13550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HF888_RS13575	COG0583	DNA-binding transcription factor activity
HF888_RS13590	COG0730	response to heat
HF888_RS13605	COG5001	Diguanylate cyclase
HF888_RS13605	COG4251	negative regulation of phosphorylation
HF888_RS13605	COG2203	Gaf domain
HF888_RS13605	COG3706	GGDEF domain
HF888_RS13615	COG3300	MHYT domain
HF888_RS13615	COG5001	Diguanylate cyclase
HF888_RS13620	COG2197	response regulator
HF888_RS13625	COG4251	negative regulation of phosphorylation
HF888_RS13655	COG0004	ammonium transporteR
HF888_RS13660	COG4302	ethanolamine ammonia-lyase activity
HF888_RS13665	COG4303	Ethanolamine ammonia lyase large subunit
HF888_RS13685	COG0840	transmembrane signaling receptor activity
HF888_RS13690	COG3290	protein histidine kinase activity
HF888_RS13690	COG0840	transmembrane signaling receptor activity
HF888_RS13695	COG0009	L-threonylcarbamoyladenylate synthase
HF888_RS13700	COG0175	sulfate reduction
HF888_RS13705	COG3002	Belongs to the UPF0753 family
HF888_RS13710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HF888_RS13715	COG0583	DNA-binding transcription factor activity
HF888_RS13725	COG0028	Belongs to the TPP enzyme family
HF888_RS13735	COG0471	metal ion transport
HF888_RS13740	COG2193	ferroxidase activity
HF888_RS13760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF888_RS13765	COG4215	(ABC) transporter
HF888_RS13770	COG4160	amino acid transport
HF888_RS13785	COG2267	carboxylic ester hydrolase activity
HF888_RS13795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF888_RS13800	COG0546	phosphoglycolate phosphatase activity
HF888_RS13815	COG1064	alcohol dehydrogenase
HF888_RS13830	COG2119	membrane
HF888_RS13835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HF888_RS13845	COG2203	Gaf domain
HF888_RS13845	COG2200	EAL domain
HF888_RS13845	COG2199	diguanylate cyclase activity
HF888_RS13850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HF888_RS13855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF888_RS13860	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HF888_RS13915	COG0475	glutathione-regulated potassium exporter activity
HF888_RS13915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HF888_RS13920	COG2249	NAD(P)H dehydrogenase (quinone) activity
HF888_RS13930	COG0415	Belongs to the DNA photolyase family
HF888_RS13935	COG0415	Belongs to the DNA photolyase family
HF888_RS13945	COG3046	protein related to deoxyribodipyrimidine photolyase
HF888_RS13950	COG2205	protein histidine kinase activity
HF888_RS13960	COG1741	Belongs to the pirin family
HF888_RS13965	COG1741	Belongs to the pirin family
HF888_RS13990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HF888_RS14015	COG0527	aspartate kinase activity
HF888_RS14020	COG1917	Cupin 2, conserved barrel domain protein
HF888_RS14050	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS14060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HF888_RS14085	COG0415	Belongs to the DNA photolyase family
HF888_RS14095	COG1595	DNA-templated transcription, initiation
HF888_RS14105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HF888_RS14110	COG2252	PERMEase
HF888_RS14115	COG0668	transmembrane transport
HF888_RS14145	COG2827	Endonuclease containing a URI domain
HF888_RS14160	COG3530	Putative quorum-sensing-regulated virulence factor
HF888_RS14165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HF888_RS14190	COG0579	oxidoreductase
HF888_RS14205	COG0625	glutathione transferase activity
HF888_RS14215	COG2738	Putative neutral zinc metallopeptidase
HF888_RS14220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HF888_RS14235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HF888_RS14235	COG0392	lysyltransferase activity
HF888_RS14245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HF888_RS14250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HF888_RS14260	COG0179	Fumarylacetoacetate (FAA) hydrolase
HF888_RS14265	COG0277	FAD linked oxidase domain protein
HF888_RS14270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HF888_RS14275	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HF888_RS14285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HF888_RS14290	COG1120	ATPase activity
HF888_RS14300	COG1022	Amp-dependent synthetase and ligase
HF888_RS14320	COG0583	DNA-binding transcription factor activity
HF888_RS14330	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HF888_RS14355	COG1862	Preprotein translocase
HF888_RS14365	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HF888_RS14390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HF888_RS14395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HF888_RS14400	COG2197	response regulator
HF888_RS14405	COG5002	protein histidine kinase activity
HF888_RS14405	COG0784	Response regulator, receiver
HF888_RS14425	COG0795	lipopolysaccharide-transporting ATPase activity
HF888_RS14430	COG0795	lipopolysaccharide-transporting ATPase activity
HF888_RS14435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HF888_RS14450	COG4067	protein conserved in archaea
HF888_RS14450	COG0189	ligase activity
HF888_RS14470	COG0525	valine-tRNA ligase activity
HF888_RS14485	COG0385	Bile acid
HF888_RS14490	COG1028	Short-chain dehydrogenase reductase Sdr
HF888_RS14495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF888_RS14500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HF888_RS14505	COG0049	tRNA binding
HF888_RS14520	COG0085	RNA polymerase activity
HF888_RS14525	COG0222	ribosome binding
HF888_RS14530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HF888_RS14535	COG0081	regulation of translation
HF888_RS14540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HF888_RS14565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF888_RS14590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HF888_RS14595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HF888_RS14595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HF888_RS14605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HF888_RS14610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HF888_RS14615	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HF888_RS14620	COG0330	HflC and HflK could
HF888_RS14625	COG0330	HflC and HflK could
HF888_RS14630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HF888_RS14635	COG1923	regulation of RNA biosynthetic process
HF888_RS14645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HF888_RS14650	COG0860	N-Acetylmuramoyl-L-alanine amidase
HF888_RS14655	COG0802	atpase or kinase
HF888_RS14660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HF888_RS14660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HF888_RS14675	COG4176	ABC-type proline glycine betaine transport system permease component
HF888_RS14680	COG2113	Glycine betaine
HF888_RS14700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HF888_RS14705	COG1162	GTPase activity
HF888_RS14710	COG0688	phosphatidylethanolamine metabolic process
HF888_RS14725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HF888_RS14730	COG1360	Flagellar Motor Protein
HF888_RS14740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF888_RS14745	COG0557	exoribonuclease II activity
HF888_RS14755	COG1360	Flagellar Motor Protein
HF888_RS14760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HF888_RS14765	COG1722	exodeoxyribonuclease VII activity
HF888_RS14770	COG0142	geranyltranstransferase activity
HF888_RS14775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HF888_RS14805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HF888_RS14830	COG0653	protein targeting
HF888_RS14865	COG2095	MarC family integral membrane protein
HF888_RS14870	COG1960	acyl-CoA dehydrogenase activity
HF888_RS14885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HF888_RS14890	COG1509	lysine 2,3-aminomutase activity
HF888_RS14900	COG5002	protein histidine kinase activity
HF888_RS14900	COG5001	Diguanylate cyclase
HF888_RS14910	COG0018	arginyl-trna synthetase
HF888_RS14925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HF888_RS14930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HF888_RS14945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HF888_RS14965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HF888_RS14970	COG0140	phosphoribosyl-ATP diphosphatase activity
HF888_RS14975	COG0537	adenosine 5'-monophosphoramidase activity
HF888_RS14985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HF888_RS14995	COG0733	neurotransmitter:sodium symporter activity
HF888_RS15010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HF888_RS15015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HF888_RS15030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF888_RS15030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF888_RS15035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HF888_RS15055	COG1612	heme a metabolic process
HF888_RS15080	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HF888_RS15085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF888_RS15090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HF888_RS15110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HF888_RS15125	COG3150	esterase
HF888_RS15130	COG1538	Outer membrane efflux protein
HF888_RS15135	COG0494	nUDIX hydrolase
HF888_RS15145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HF888_RS15150	COG1519	Transferase
HF888_RS15155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HF888_RS15155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HF888_RS15160	COG1560	Kdo2-lipid A biosynthetic process
HF888_RS15175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HF888_RS15185	COG0583	DNA-binding transcription factor activity
HF888_RS15195	COG1984	allophanate hydrolase subunit 2
HF888_RS15210	COG4336	lyase activity
HF888_RS15215	COG1115	amino acid carrier protein
HF888_RS15220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HF888_RS15230	COG0488	(ABC) transporter
HF888_RS15240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HF888_RS15245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HF888_RS15250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HF888_RS15260	COG0493	'glutamate synthase
HF888_RS15265	COG0067	glutamate synthase
HF888_RS15265	COG0069	glutamate synthase activity
HF888_RS15265	COG0070	glutamate synthase
HF888_RS15270	COG3267	Type II secretory pathway component ExeA
HF888_RS15270	COG3409	Peptidoglycan-binding domain 1 protein
HF888_RS15275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HF888_RS15320	COG1490	D-aminoacyl-tRNA deacylase activity
HF888_RS15340	COG3852	Histidine kinase
HF888_RS15345	COG2204	response regulator
HF888_RS15385	COG1459	type II secretion system
HF888_RS15390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HF888_RS15440	COG2814	Major facilitator Superfamily
HF888_RS15460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HF888_RS15475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HF888_RS15490	COG1178	ABC-type Fe3 transport system permease component
HF888_RS15495	COG3842	ATPase activity
HF888_RS15505	COG0537	adenosine 5'-monophosphoramidase activity
HF888_RS15510	COG0076	glutamate decarboxylase activity
HF888_RS15515	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HF888_RS15545	COG0217	transcriptional regulatory protein
HF888_RS15560	COG1119	ATPase activity
HF888_RS15570	COG3239	Fatty acid desaturase
HF888_RS15600	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HF888_RS15610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HF888_RS15615	COG3025	triphosphatase activity
HF888_RS15620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HF888_RS15620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HF888_RS15635	COG0129	dihydroxy-acid dehydratase activity
HF888_RS15650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF888_RS15655	COG1702	phosphate starvation-inducible protein PhoH
HF888_RS15660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HF888_RS15665	COG4535	Mg2 and Co2 transporter CorC
HF888_RS15685	COG0840	transmembrane signaling receptor activity
HF888_RS15695	COG0495	leucyl-tRNA aminoacylation
HF888_RS15705	COG1466	dna polymerase III delta subunit
HF888_RS15720	COG0435	Glutathione S-transferase
HF888_RS15725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HF888_RS15730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HF888_RS15735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HF888_RS15740	COG0006	proline dipeptidase activity
HF888_RS15765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HF888_RS15770	COG4191	Histidine kinase
HF888_RS15770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF888_RS15775	COG3437	response regulator, receiver
HF888_RS15775	COG0784	Response regulator, receiver
HF888_RS15815	COG0126	phosphoglycerate kinase activity
HF888_RS15830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HF888_RS15835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HF888_RS15845	COG2199	diguanylate cyclase activity
HF888_RS15850	COG1346	cytolysis
HF888_RS15855	COG1380	Effector of murein hydrolase LrgA
HF888_RS15860	COG1024	Enoyl-CoA hydratase
HF888_RS15865	COG0181	hydroxymethylbilane synthase activity
HF888_RS15895	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HF888_RS15900	COG4988	ABC transporter
HF888_RS15905	COG1294	oxidase, subunit
HF888_RS15910	COG1271	oxidase subunit
HF888_RS15915	COG2050	protein possibly involved in aromatic compounds catabolism
HF888_RS15925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HF888_RS15965	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HF888_RS15975	COG3130	regulation of translation
HF888_RS15980	COG2918	glutathione biosynthetic process
HF888_RS15985	COG2183	response to ionizing radiation
HF888_RS16005	COG2201	protein-glutamate methylesterase activity
HF888_RS16010	COG0784	Response regulator, receiver
HF888_RS16010	COG2198	Histidine kinase
HF888_RS16010	COG0643	Histidine kinase
HF888_RS16020	COG0840	transmembrane signaling receptor activity
HF888_RS16040	COG0189	ligase activity
HF888_RS16050	COG1678	Uncharacterized ACR, COG1678
HF888_RS16055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HF888_RS16060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HF888_RS16065	COG0540	Belongs to the ATCase OTCase family
HF888_RS16090	COG0596	Alpha beta hydrolase
HF888_RS16095	COG0004	ammonium transporteR
HF888_RS16115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HF888_RS16120	COG0830	nickel cation binding
HF888_RS16125	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HF888_RS16130	COG0804	urea catabolic process
HF888_RS16135	COG0832	Belongs to the urease beta subunit family
HF888_RS16140	COG0831	urea catabolic process
HF888_RS16145	COG0829	nickel cation binding
HF888_RS16155	COG0411	ABC transporter
HF888_RS16175	COG0347	Belongs to the P(II) protein family
HF888_RS16180	COG2960	long-chain fatty acid transporting porin activity
HF888_RS16190	COG0686	Belongs to the AlaDH PNT family
HF888_RS16205	COG1522	sequence-specific DNA binding
HF888_RS16215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HF888_RS16220	COG1288	antiporter activity
HF888_RS16225	COG4771	TonB-dependent receptor
HF888_RS16230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HF888_RS16240	COG1012	belongs to the aldehyde dehydrogenase family
HF888_RS16245	COG3724	N-succinylarginine dihydrolase activity
HF888_RS16255	COG0604	alcohol dehydrogenase
HF888_RS16275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HF888_RS16415	COG1475	DNA binding