locus-tag	class	description
JI75_RS00015	COG0592	DNA-directed DNA polymerase activity
JI75_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JI75_RS00030	COG0187	DNA topoisomerase II activity
JI75_RS00050	COG0484	heat shock protein binding
JI75_RS00055	COG1217	gtp-binding protein TYPA
JI75_RS00060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JI75_RS00115	COG0629	single-stranded DNA binding
JI75_RS00120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JI75_RS00130	COG0305	Participates in initiation and elongation during chromosome replication
JI75_RS00135	COG0420	3'-5' exonuclease activity
JI75_RS00140	COG4717	serine-type aminopeptidase activity
JI75_RS00145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JI75_RS00155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JI75_RS00170	COG0674	pyruvate-flavodoxin oxidoreductase activity
JI75_RS00180	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
JI75_RS00185	COG1757	Na H antiporter
JI75_RS00205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JI75_RS00220	COG2815	serine threonine protein kinase
JI75_RS00220	COG0515	serine threonine protein kinase
JI75_RS00250	COG1473	amidohydrolase
JI75_RS00260	COG3442	glutamine amidotransferase
JI75_RS00265	COG1316	TRANSCRIPTIONal
JI75_RS00270	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JI75_RS00275	COG0708	Exodeoxyribonuclease III
JI75_RS00280	COG0302	gtp cyclohydrolase
JI75_RS00285	COG3830	Belongs to the UPF0237 family
JI75_RS00290	COG1970	mechanosensitive ion channel activity
JI75_RS00295	COG1253	flavin adenine dinucleotide binding
JI75_RS00305	COG3177	Filamentation induced by cAMP protein fic
JI75_RS00315	COG3853	Toxic anion resistance protein (TelA)
JI75_RS00320	COG1959	2 iron, 2 sulfur cluster binding
JI75_RS00325	COG1125	glycine betaine transport
JI75_RS00325	COG0517	IMP dehydrogenase activity
JI75_RS00330	COG1732	Glycine betaine
JI75_RS00335	COG0259	pyridoxamine-phosphate oxidase activity
JI75_RS00365	COG1518	maintenance of DNA repeat elements
JI75_RS00370	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
JI75_RS00395	COG2197	response regulator
JI75_RS00400	COG1053	succinate dehydrogenase
JI75_RS00400	COG3976	FMN-binding domain protein
JI75_RS00405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JI75_RS00410	COG0156	8-amino-7-oxononanoate synthase activity
JI75_RS00430	COG1368	sulfuric ester hydrolase activity
JI75_RS00455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JI75_RS00465	COG0019	diaminopimelate decarboxylase activity
JI75_RS00470	COG0460	homoserine dehydrogenase
JI75_RS00475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JI75_RS00480	COG1053	succinate dehydrogenase
JI75_RS00480	COG3976	FMN-binding domain protein
JI75_RS00485	COG2909	trisaccharide binding
JI75_RS00495	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JI75_RS00500	COG0243	molybdopterin cofactor binding
JI75_RS00505	COG0437	4 iron, 4 sulfur cluster binding
JI75_RS00515	COG2205	protein histidine kinase activity
JI75_RS00515	COG0784	Response regulator, receiver
JI75_RS00520	COG0745	RESPONSE REGULATOR receiver
JI75_RS00525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JI75_RS00540	COG1053	succinate dehydrogenase
JI75_RS00540	COG3976	FMN-binding domain protein
JI75_RS00540	COG0431	NADPH-dependent FMN reductase
JI75_RS00545	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JI75_RS00550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JI75_RS00555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JI75_RS00565	COG0477	Major facilitator Superfamily
JI75_RS00575	COG0697	spore germination
JI75_RS00590	COG3976	FMN-binding domain protein
JI75_RS00590	COG1053	succinate dehydrogenase
JI75_RS00595	COG2909	trisaccharide binding
JI75_RS00605	COG2226	methyltransferase
JI75_RS00610	COG0601	transmembrane transport
JI75_RS00615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JI75_RS00635	COG0534	Mate efflux family protein
JI75_RS00655	COG0385	Bile acid
JI75_RS00660	COG2197	response regulator
JI75_RS00665	COG0243	molybdopterin cofactor binding
JI75_RS00670	COG0437	4 iron, 4 sulfur cluster binding
JI75_RS00675	COG3302	dmso reductase anchor subunit
JI75_RS00690	COG2873	o-acetylhomoserine
JI75_RS00705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JI75_RS00715	COG0717	Belongs to the dCTP deaminase family
JI75_RS00720	COG2814	Major facilitator Superfamily
JI75_RS00740	COG1121	(ABC) transporter
JI75_RS00745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JI75_RS00775	COG1115	amino acid carrier protein
JI75_RS00795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JI75_RS00805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JI75_RS00815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JI75_RS00815	COG1648	precorrin-2 dehydrogenase activity
JI75_RS00820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JI75_RS00825	COG0181	hydroxymethylbilane synthase activity
JI75_RS00835	COG0535	radical SAM domain protein
JI75_RS00840	COG0113	porphobilinogen synthase activity
JI75_RS00845	COG0535	radical SAM domain protein
JI75_RS00850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JI75_RS00865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JI75_RS00875	COG1126	abc transporter atp-binding protein
JI75_RS00910	COG0864	Transcriptional regulator
JI75_RS00915	COG0309	Hydrogenase expression formation protein (HypE)
JI75_RS00925	COG0443	Heat shock 70 kDa protein
JI75_RS00930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JI75_RS00935	COG0484	heat shock protein binding
JI75_RS00940	COG0789	Transcriptional regulator
JI75_RS00945	COG0542	response to heat
JI75_RS00950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JI75_RS00960	COG1162	GTPase activity
JI75_RS00970	COG0730	response to heat
JI75_RS00975	COG3275	phosphorelay sensor kinase activity
JI75_RS00985	COG0385	Bile acid
JI75_RS01025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JI75_RS01030	COG1181	Belongs to the D-alanine--D-alanine ligase family
JI75_RS01045	COG0398	Pfam SNARE associated Golgi protein
JI75_RS01060	COG0217	transcriptional regulatory protein
JI75_RS01065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JI75_RS01070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JI75_RS01075	COG0632	four-way junction helicase activity
JI75_RS01080	COG2255	four-way junction helicase activity
JI75_RS01090	COG1278	Cold shock
JI75_RS01110	COG0343	queuine tRNA-ribosyltransferase activity
JI75_RS01115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JI75_RS01115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JI75_RS01125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JI75_RS01130	COG1122	ATPase activity
JI75_RS01135	COG1122	ATPase activity
JI75_RS01170	COG1074	ATP-dependent DNA helicase activity
JI75_RS01190	COG1846	Transcriptional regulator
JI75_RS01195	COG2081	HI0933 family
JI75_RS01210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JI75_RS01220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JI75_RS01240	COG0356	it plays a direct role in the translocation of protons across the membrane
JI75_RS01250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JI75_RS01260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JI75_RS01265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JI75_RS01270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JI75_RS01290	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JI75_RS01305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JI75_RS01310	COG0651	ATP synthesis coupled electron transport
JI75_RS01315	COG0650	Formate hydrogenlyase subunit 4
JI75_RS01320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JI75_RS01325	COG4237	Hydrogenase 4 membrane
JI75_RS01330	COG0651	ATP synthesis coupled electron transport
JI75_RS01335	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
JI75_RS01335	COG3261	NADH dehydrogenase
JI75_RS01340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JI75_RS01345	COG3260	NADH ubiquinone oxidoreductase 20
JI75_RS01360	COG2116	formate transmembrane transporter activity
JI75_RS01375	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
JI75_RS01385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JI75_RS01390	COG1924	4 iron, 4 sulfur cluster binding
JI75_RS01405	COG0101	tRNA pseudouridine synthase activity
JI75_RS01415	COG3842	ATPase activity
JI75_RS01425	COG0438	transferase activity, transferring glycosyl groups
JI75_RS01425	COG0297	glycogen (starch) synthase activity
JI75_RS01435	COG0601	transmembrane transport
JI75_RS01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JI75_RS01450	COG4172	Belongs to the ABC transporter superfamily
JI75_RS01460	COG1120	ATPase activity
JI75_RS01465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JI75_RS01475	COG0733	neurotransmitter:sodium symporter activity
JI75_RS01480	COG0012	GTP binding
JI75_RS01495	COG0514	ATP-dependent DNA helicase (RecQ)
JI75_RS01500	COG1477	protein flavinylation
JI75_RS01520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JI75_RS01525	COG0154	amidase activity
JI75_RS01530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JI75_RS01535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JI75_RS01540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JI75_RS01545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JI75_RS01550	COG0131	Imidazoleglycerol-phosphate dehydratase
JI75_RS01555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JI75_RS01560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JI75_RS01565	COG0107	imidazoleglycerol-phosphate synthase activity
JI75_RS01570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JI75_RS01615	COG0616	signal peptide processing
JI75_RS01620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JI75_RS01620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JI75_RS01625	COG1388	LysM domain
JI75_RS01625	COG0791	NLP P60 protein
JI75_RS01630	COG0328	RNA-DNA hybrid ribonuclease activity
JI75_RS01655	COG0052	Belongs to the universal ribosomal protein uS2 family
JI75_RS01665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JI75_RS01675	COG0316	Belongs to the HesB IscA family
JI75_RS01675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JI75_RS01695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JI75_RS01705	COG1373	ATPase (AAA superfamily
JI75_RS01720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JI75_RS01725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JI75_RS01730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JI75_RS01735	COG0193	aminoacyl-tRNA hydrolase activity
JI75_RS01745	COG0124	histidyl-tRNA synthetase
JI75_RS01750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JI75_RS01775	COG0243	molybdopterin cofactor binding
JI75_RS01780	COG0437	4 iron, 4 sulfur cluster binding
JI75_RS01795	COG0586	Pfam SNARE associated Golgi protein
JI75_RS01800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JI75_RS01805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JI75_RS01810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JI75_RS01825	COG0513	Belongs to the DEAD box helicase family
JI75_RS01830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JI75_RS01855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JI75_RS01860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JI75_RS01870	COG0105	UTP biosynthetic process
JI75_RS01875	COG1077	Cell shape determining protein MreB Mrl
JI75_RS01890	COG0768	penicillin binding
JI75_RS01895	COG0772	Belongs to the SEDS family
JI75_RS01920	COG0783	Belongs to the Dps family
JI75_RS01945	COG1132	(ABC) transporter
JI75_RS01970	COG1971	Probably functions as a manganese efflux pump
JI75_RS01975	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
JI75_RS01985	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
JI75_RS02010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JI75_RS02020	COG1053	succinate dehydrogenase
JI75_RS02030	COG1921	L-seryl-tRNASec selenium transferase activity
JI75_RS02045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JI75_RS02070	COG1268	BioY protein
JI75_RS02075	COG5002	protein histidine kinase activity
JI75_RS02080	COG0745	RESPONSE REGULATOR receiver
JI75_RS02085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JI75_RS02090	COG0802	atpase or kinase
JI75_RS02095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JI75_RS02105	COG0402	S-adenosylhomocysteine deaminase activity
JI75_RS02115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JI75_RS02120	COG0805	protein transport
JI75_RS02135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JI75_RS02135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JI75_RS02140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JI75_RS02145	COG0459	protein refolding
JI75_RS02160	COG1053	succinate dehydrogenase
JI75_RS02170	COG1216	Glycosyl transferase, family 2
JI75_RS02180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JI75_RS02195	COG0583	DNA-binding transcription factor activity
JI75_RS02200	COG2855	membrane
JI75_RS02210	COG0254	rRNA binding
JI75_RS02225	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
JI75_RS02230	COG3872	metal-dependent enzyme
JI75_RS02235	COG0551	DNA topoisomerase type I activity
JI75_RS02235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JI75_RS02240	COG0281	malic enzyme
JI75_RS02245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JI75_RS02255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JI75_RS02260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JI75_RS02265	COG1774	PSP1 C-terminal conserved region
JI75_RS02270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JI75_RS02355	COG0582	viral genome integration into host DNA
JI75_RS02360	COG0629	single-stranded DNA binding
JI75_RS02560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JI75_RS02585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JI75_RS02590	COG0765	amino acid transport
JI75_RS02595	COG1126	abc transporter atp-binding protein
JI75_RS02600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JI75_RS02605	COG0528	UMP kinase activity
JI75_RS02610	COG0233	cytoplasmic translational termination
JI75_RS02615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JI75_RS02620	COG0575	Belongs to the CDS family
JI75_RS02630	COG0750	zinc metalloprotease
JI75_RS02635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JI75_RS02640	COG0442	prolyl-tRNA aminoacylation
JI75_RS02655	COG1741	Belongs to the pirin family
JI75_RS02660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JI75_RS02665	COG3404	Formiminotransferase-cyclodeaminase
JI75_RS02670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JI75_RS02685	COG0513	Belongs to the DEAD box helicase family
JI75_RS02695	COG0018	arginyl-trna synthetase
JI75_RS02725	COG2247	cell wall binding repeat
JI75_RS02725	COG0860	N-Acetylmuramoyl-L-alanine amidase
JI75_RS02735	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JI75_RS02750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JI75_RS02760	COG0544	peptidyl-prolyl cis-trans isomerase activity
JI75_RS02765	COG0740	serine-type endopeptidase activity
JI75_RS02770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JI75_RS02775	COG0525	valine-tRNA ligase activity
JI75_RS02780	COG1393	Belongs to the ArsC family
JI75_RS02790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JI75_RS02810	COG1309	transcriptional regulator
JI75_RS02820	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JI75_RS02830	COG1053	succinate dehydrogenase
JI75_RS02830	COG0431	NADPH-dependent FMN reductase
JI75_RS02830	COG3976	FMN-binding domain protein
JI75_RS02850	COG0602	queuosine metabolic process
JI75_RS02855	COG1328	CTP reductase activity
JI75_RS02860	COG2252	PERMEase
JI75_RS02875	COG0492	ferredoxin-NADP+ reductase activity
JI75_RS02880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JI75_RS02885	COG2890	protein-(glutamine-N5) methyltransferase activity
JI75_RS02890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JI75_RS02895	COG0306	phosphate transporter
JI75_RS02910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JI75_RS02920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JI75_RS02925	COG0051	transcription antitermination factor activity, RNA binding
JI75_RS02930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JI75_RS02935	COG0088	Forms part of the polypeptide exit tunnel
JI75_RS02940	COG0089	rRNA binding
JI75_RS02960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JI75_RS02965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JI75_RS02975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JI75_RS02980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JI75_RS02985	COG0255	Belongs to the universal ribosomal protein uL29 family
JI75_RS02995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JI75_RS03000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JI75_RS03005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JI75_RS03010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JI75_RS03015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JI75_RS03020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JI75_RS03025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JI75_RS03030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JI75_RS03035	COG1841	ribosomal large subunit assembly
JI75_RS03040	COG0200	Binds to the 23S rRNA
JI75_RS03050	COG1994	Peptidase M50
JI75_RS03060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JI75_RS03070	COG1053	succinate dehydrogenase
JI75_RS03070	COG3976	FMN-binding domain protein
JI75_RS03080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JI75_RS03090	COG0204	Acyl-transferase
JI75_RS03095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JI75_RS03105	COG1160	GTP binding
JI75_RS03110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JI75_RS03115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JI75_RS03120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JI75_RS03125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JI75_RS03130	COG1104	cysteine desulfurase activity
JI75_RS03140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JI75_RS03150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JI75_RS03155	COG1302	Protein conserved in bacteria
JI75_RS03160	COG1461	Dihydroxyacetone kinase
JI75_RS03165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JI75_RS03170	COG0742	ribosomal rna small subunit methyltransferase
JI75_RS03175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JI75_RS03185	COG1399	metal-binding, possibly nucleic acid-binding protein
JI75_RS03190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JI75_RS03195	COG0416	fatty acid biosynthetic process
JI75_RS03200	COG0571	ribonuclease III activity
JI75_RS03205	COG1196	nuclear chromosome segregation
JI75_RS03210	COG0552	protein localization to endoplasmic reticulum
JI75_RS03215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JI75_RS03220	COG0228	four-way junction DNA binding
JI75_RS03235	COG0336	Belongs to the RNA methyltransferase TrmD family
JI75_RS03240	COG0681	Belongs to the peptidase S26 family
JI75_RS03245	COG0752	glycyl-tRNA synthetase alpha subunit
JI75_RS03250	COG0751	glycine-tRNA ligase activity
JI75_RS03260	COG2081	HI0933 family
JI75_RS03265	COG2205	protein histidine kinase activity
JI75_RS03270	COG0745	RESPONSE REGULATOR receiver
JI75_RS03290	COG0574	Belongs to the PEP-utilizing enzyme family
JI75_RS03290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JI75_RS03295	COG0482	sulfurtransferase activity
JI75_RS03300	COG1959	2 iron, 2 sulfur cluster binding
JI75_RS03305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JI75_RS03310	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JI75_RS03325	COG1053	succinate dehydrogenase
JI75_RS03325	COG3976	FMN-binding domain protein
JI75_RS03335	COG0335	large ribosomal subunit rRNA binding
JI75_RS03345	COG0792	nuclease activity
JI75_RS03355	COG0758	DNA mediated transformation
JI75_RS03360	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JI75_RS03365	COG4974	Belongs to the 'phage' integrase family
JI75_RS03370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JI75_RS03385	COG2247	cell wall binding repeat
JI75_RS03385	COG0860	N-Acetylmuramoyl-L-alanine amidase
JI75_RS03390	COG0322	excinuclease ABC activity
JI75_RS03395	COG1660	Displays ATPase and GTPase activities
JI75_RS03400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JI75_RS03405	COG1481	regulation of sporulation
JI75_RS03415	COG0126	phosphoglycerate kinase activity
JI75_RS03420	COG0149	triose-phosphate isomerase activity
JI75_RS03425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JI75_RS03430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JI75_RS03445	COG1011	Hydrolase
JI75_RS03465	COG1733	regulation of RNA biosynthetic process
JI75_RS03520	COG0861	Integral membrane protein TerC family
JI75_RS03530	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JI75_RS03535	COG2738	Putative neutral zinc metallopeptidase
JI75_RS03540	COG1570	exodeoxyribonuclease VII activity
JI75_RS03545	COG1722	exodeoxyribonuclease VII activity
JI75_RS03550	COG0537	adenosine 5'-monophosphoramidase activity
JI75_RS03555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JI75_RS03560	COG0280	phosphate acetyltransferase
JI75_RS03565	COG0463	Glycosyl transferase, family 2
JI75_RS03565	COG1216	Glycosyl transferase, family 2
JI75_RS03570	COG1937	Protein conserved in bacteria
JI75_RS03575	COG2217	Heavy metal translocating P-type atpase
JI75_RS03580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JI75_RS03590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JI75_RS03600	COG0564	pseudouridine synthase activity
JI75_RS03605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JI75_RS03610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JI75_RS03620	COG1307	EDD domain protein, DegV family
JI75_RS03645	COG3260	NADH ubiquinone oxidoreductase 20
JI75_RS03655	COG0649	NAD binding
JI75_RS03675	COG0779	Required for maturation of 30S ribosomal subunits
JI75_RS03680	COG0195	Participates in both transcription termination and antitermination
JI75_RS03695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JI75_RS03705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JI75_RS03710	COG0196	riboflavin kinase activity
JI75_RS03715	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
JI75_RS03725	COG0622	Phosphoesterase
JI75_RS03730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JI75_RS03745	COG0242	peptide deformylase activity
JI75_RS03755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JI75_RS03755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JI75_RS03760	COG1494	fructose-1,6-bisphosphatase
JI75_RS03775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JI75_RS03780	COG0540	Belongs to the ATCase OTCase family
JI75_RS03785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JI75_RS03790	COG0543	2 iron, 2 sulfur cluster binding
JI75_RS03795	COG0167	dihydroorotate dehydrogenase activity
JI75_RS03800	COG0284	orotidine-5'-phosphate decarboxylase activity
JI75_RS03810	COG0194	GDP metabolic process
JI75_RS03825	COG1596	polysaccharide export
JI75_RS03825	COG1555	photosystem II stabilization
JI75_RS03830	COG2333	competence protein COMEC
JI75_RS03830	COG0658	competence protein
JI75_RS03855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JI75_RS03865	COG1420	regulation of RNA biosynthetic process
JI75_RS03875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JI75_RS03890	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JI75_RS03900	COG0515	serine threonine protein kinase
JI75_RS03900	COG2815	serine threonine protein kinase
JI75_RS03915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JI75_RS03920	COG1185	polyribonucleotide nucleotidyltransferase activity
JI75_RS03935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JI75_RS03940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JI75_RS03945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JI75_RS03950	COG1674	ftsk spoiiie
JI75_RS03960	COG1666	GTP binding
JI75_RS03965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JI75_RS03970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JI75_RS03975	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JI75_RS03980	COG2137	regulation of response to DNA damage stimulus
JI75_RS03985	COG1418	mRNA catabolic process
JI75_RS03995	COG2359	stage V sporulation protein S
JI75_RS04005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JI75_RS04015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JI75_RS04020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JI75_RS04030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JI75_RS04035	COG0756	dUTP diphosphatase activity
JI75_RS04055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JI75_RS04075	COG1686	Belongs to the peptidase S11 family
JI75_RS04095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JI75_RS04100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JI75_RS04105	COG0440	acetolactate synthase activity
JI75_RS04110	COG0028	Belongs to the TPP enzyme family
JI75_RS04115	COG0129	dihydroxy-acid dehydratase activity
JI75_RS04120	COG1605	Chorismate mutase
JI75_RS04120	COG0077	Prephenate dehydratase
JI75_RS04125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JI75_RS04130	COG1968	undecaprenyl-diphosphatase activity
JI75_RS04135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JI75_RS04135	COG0519	Catalyzes the synthesis of GMP from XMP
JI75_RS04150	COG4974	Belongs to the 'phage' integrase family
JI75_RS04170	COG0500	methyltransferase
JI75_RS04195	COG0792	nuclease activity
JI75_RS04200	COG1192	Involved in chromosome partitioning
JI75_RS04235	COG1401	restriction endodeoxyribonuclease activity
JI75_RS04275	COG0791	NLP P60 protein
JI75_RS04295	COG3505	Type IV secretory pathway VirD4
JI75_RS04360	COG1597	lipid kinase activity
JI75_RS04365	COG0745	RESPONSE REGULATOR receiver
JI75_RS04370	COG2205	protein histidine kinase activity
JI75_RS04370	COG0784	Response regulator, receiver
JI75_RS04420	COG3976	FMN-binding domain protein
JI75_RS04420	COG1053	succinate dehydrogenase
JI75_RS04420	COG1053	succinate dehydrogenase
JI75_RS04420	COG3976	FMN-binding domain protein
JI75_RS04425	COG1131	(ABC) transporter
JI75_RS04465	COG1797	cobyrinic acid a,c-diamide synthase activity
JI75_RS04470	COG2920	part of a sulfur-relay system
JI75_RS04520	COG2855	membrane
JI75_RS04525	COG2221	Nitrite and sulphite reductase 4Fe-4S
JI75_RS04530	COG2221	Nitrite and sulphite reductase 4Fe-4S
JI75_RS04555	COG0583	DNA-binding transcription factor activity
JI75_RS04585	COG2197	response regulator
JI75_RS04610	COG1053	succinate dehydrogenase
JI75_RS04620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JI75_RS04625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JI75_RS04640	COG0778	Nitroreductase
JI75_RS04650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JI75_RS04655	COG0573	inorganic phosphate transmembrane transporter activity
JI75_RS04660	COG0581	inorganic phosphate transmembrane transporter activity
JI75_RS04665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JI75_RS04675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JI75_RS04685	COG0803	Belongs to the bacterial solute-binding protein 9 family
JI75_RS04695	COG1811	Na channel or pump
JI75_RS04700	COG0512	Glutamine amidotransferase of anthranilate synthase
JI75_RS04705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JI75_RS04710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JI75_RS04730	COG0004	ammonium transporteR
JI75_RS04735	COG0347	Belongs to the P(II) protein family
JI75_RS04745	COG0494	nUDIX hydrolase
JI75_RS04770	COG0697	spore germination
JI75_RS04805	COG0306	phosphate transporter
JI75_RS04815	COG0745	RESPONSE REGULATOR receiver
JI75_RS04825	COG1757	Na H antiporter
JI75_RS04830	COG0252	asparaginase activity
JI75_RS04835	COG2814	Major facilitator Superfamily
JI75_RS04845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JI75_RS04870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JI75_RS04875	COG0251	oxidation-reduction process
JI75_RS04880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JI75_RS04885	COG4750	Nucleotidyl transferase
JI75_RS04895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JI75_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
JI75_RS04905	COG3301	Polysulphide reductase, NrfD
JI75_RS04925	COG2197	response regulator
JI75_RS04935	COG0531	amino acid
JI75_RS04945	COG3022	response to hydroperoxide
JI75_RS04960	COG0433	COG0433 Predicted ATPase
JI75_RS04970	COG4215	(ABC) transporter
JI75_RS04975	COG1126	abc transporter atp-binding protein
JI75_RS05000	COG1464	Belongs to the NlpA lipoprotein family
JI75_RS05020	COG0573	inorganic phosphate transmembrane transporter activity
JI75_RS05025	COG0581	inorganic phosphate transmembrane transporter activity
JI75_RS05030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JI75_RS05040	COG3118	belongs to the thioredoxin family
JI75_RS05040	COG0492	ferredoxin-NADP+ reductase activity
JI75_RS05055	COG0583	DNA-binding transcription factor activity
JI75_RS05070	COG0745	RESPONSE REGULATOR receiver
JI75_RS05075	COG1136	(ABC) transporter
JI75_RS05095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JI75_RS05100	COG1854	S-ribosylhomocysteine lyase activity
JI75_RS05105	COG0720	synthase
JI75_RS05110	COG1115	amino acid carrier protein
JI75_RS05115	COG1045	serine acetyltransferase
JI75_RS05125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JI75_RS05140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JI75_RS05160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JI75_RS05165	COG0437	4 iron, 4 sulfur cluster binding
JI75_RS05170	COG0243	molybdopterin cofactor binding
JI75_RS05190	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JI75_RS05220	COG1492	cobalamin metabolic process
JI75_RS05225	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JI75_RS05230	COG1797	cobyrinic acid a,c-diamide synthase activity
JI75_RS05260	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
JI75_RS05265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JI75_RS05275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JI75_RS05315	COG0484	heat shock protein binding
JI75_RS05335	COG1301	dicarboxylic acid transport
JI75_RS05355	COG0531	amino acid
JI75_RS05360	COG4750	Nucleotidyl transferase
JI75_RS05365	COG1228	amidohydrolase
JI75_RS05370	COG1316	TRANSCRIPTIONal
JI75_RS05385	COG0437	4 iron, 4 sulfur cluster binding
JI75_RS05405	COG0437	4 iron, 4 sulfur cluster binding
JI75_RS05430	COG1132	(ABC) transporter
JI75_RS05435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JI75_RS05450	COG0733	neurotransmitter:sodium symporter activity
JI75_RS05455	COG0577	efflux transmembrane transporter activity
JI75_RS05460	COG1136	(ABC) transporter
JI75_RS05465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JI75_RS05470	COG0789	Transcriptional regulator
JI75_RS05480	COG3579	cysteine-type endopeptidase activity
JI75_RS05490	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JI75_RS05525	COG0826	peptidase U32
JI75_RS05530	COG0215	cysteine-tRNA ligase activity
JI75_RS05535	COG0549	Belongs to the carbamate kinase family
JI75_RS05540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JI75_RS05545	COG2235	arginine
JI75_RS05555	COG1834	amidinotransferase
JI75_RS05570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JI75_RS05575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JI75_RS05580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JI75_RS05585	COG0542	response to heat
JI75_RS05595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JI75_RS05600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JI75_RS05625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JI75_RS05630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JI75_RS05640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JI75_RS05645	COG4509	Sortase family
JI75_RS05650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JI75_RS05655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JI75_RS05655	COG0140	phosphoribosyl-ATP diphosphatase activity
JI75_RS05660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JI75_RS05665	COG0085	RNA polymerase activity
JI75_RS05680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JI75_RS05690	COG0133	tryptophan synthase activity
JI75_RS05695	COG0159	tryptophan synthase activity
JI75_RS05720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JI75_RS05740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JI75_RS05810	COG0557	exoribonuclease II activity
JI75_RS05820	COG2177	Part of the ABC transporter FtsEX involved in
JI75_RS05825	COG2884	Cell division ATP-binding protein ftsE
JI75_RS05830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JI75_RS05835	COG3959	Transketolase, thiamine diphosphate binding domain
JI75_RS05840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JI75_RS05845	COG0653	protein targeting
JI75_RS05855	COG0799	negative regulation of ribosome biogenesis
JI75_RS05860	COG1713	HD superfamily hydrolase involved in NAD metabolism
JI75_RS05870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JI75_RS05875	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JI75_RS05880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JI75_RS05885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JI75_RS05890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JI75_RS05905	COG0174	glutamine synthetase
JI75_RS05910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JI75_RS05915	COG2011	ABC-type metal ion transport system permease component
JI75_RS05925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JI75_RS05930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JI75_RS05955	COG1216	Glycosyl transferase, family 2
JI75_RS05960	COG1216	Glycosyl transferase, family 2
JI75_RS05980	COG0562	UDP-galactopyranose mutase
JI75_RS05985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JI75_RS05990	COG0562	UDP-galactopyranose mutase
JI75_RS06015	COG0617	tRNA 3'-terminal CCA addition
JI75_RS06040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JI75_RS06050	COG0351	phosphomethylpyrimidine kinase
JI75_RS06050	COG0352	thiamine-phosphate diphosphorylase activity
JI75_RS06055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JI75_RS06065	COG1872	DUF167
JI75_RS06075	COG0762	integral membrane protein
JI75_RS06080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JI75_RS06090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JI75_RS06100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JI75_RS06105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JI75_RS06110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JI75_RS06115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JI75_RS06120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JI75_RS06125	COG0772	Belongs to the SEDS family
JI75_RS06130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JI75_RS06135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JI75_RS06140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JI75_RS06150	COG0768	penicillin binding
JI75_RS06160	COG0275	rRNA processing
JI75_RS06170	COG4974	Belongs to the 'phage' integrase family
JI75_RS06185	COG0367	asparagine synthase
JI75_RS06205	COG0243	molybdopterin cofactor binding
JI75_RS06235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JI75_RS06240	COG0728	peptidoglycan biosynthetic process
JI75_RS06255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JI75_RS06260	COG0250	Participates in transcription elongation, termination and antitermination
JI75_RS06265	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JI75_RS06275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JI75_RS06280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JI75_RS06300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JI75_RS06310	COG0243	molybdopterin cofactor binding
JI75_RS06330	COG0745	RESPONSE REGULATOR receiver
JI75_RS06335	COG3850	Histidine kinase
JI75_RS06335	COG5002	protein histidine kinase activity
JI75_RS06340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JI75_RS06355	COG0747	negative chemotaxis
JI75_RS06370	COG4608	Belongs to the ABC transporter superfamily
JI75_RS06375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JI75_RS06385	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JI75_RS06405	COG0563	adenylate kinase activity
JI75_RS06415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JI75_RS06420	COG0488	(ABC) transporter
JI75_RS06445	COG0180	Tryptophanyl-tRNA synthetase
JI75_RS06455	COG0493	'glutamate synthase
JI75_RS06465	COG0626	cystathionine gamma-synthase activity
JI75_RS06470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JI75_RS06485	COG1053	succinate dehydrogenase
JI75_RS06485	COG3976	FMN-binding domain protein
JI75_RS06485	COG0431	NADPH-dependent FMN reductase
JI75_RS06490	COG2909	trisaccharide binding
JI75_RS06500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JI75_RS06500	COG0116	Belongs to the methyltransferase superfamily
JI75_RS06505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JI75_RS06510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JI75_RS06520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JI75_RS06525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JI75_RS06535	COG1410	methionine synthase
JI75_RS06535	COG0646	methionine synthase
JI75_RS06540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JI75_RS06550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JI75_RS06555	COG2375	cellular response to nickel ion
JI75_RS06555	COG1132	(ABC) transporter
JI75_RS06560	COG2375	cellular response to nickel ion
JI75_RS06560	COG1132	(ABC) transporter
JI75_RS06565	COG1129	ABC transporter
JI75_RS06590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JI75_RS06600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JI75_RS06605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JI75_RS06610	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JI75_RS06615	COG0424	maF-like protein
JI75_RS06620	COG0037	tRNA processing
JI75_RS06620	COG0590	tRNA wobble adenosine to inosine editing
JI75_RS06635	COG3279	Response regulator of the LytR AlgR family
JI75_RS06655	COG3177	Filamentation induced by cAMP protein fic
JI75_RS06660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JI75_RS06675	COG1528	Iron-storage protein
JI75_RS06680	COG1136	(ABC) transporter
JI75_RS06685	COG0436	Aminotransferase
JI75_RS06695	COG2050	protein possibly involved in aromatic compounds catabolism
JI75_RS06705	COG1960	acyl-CoA dehydrogenase activity
JI75_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
JI75_RS06725	COG2814	Major facilitator Superfamily
JI75_RS06740	COG0318	PFAM AMP-dependent synthetase and ligase
JI75_RS06750	COG1960	acyl-CoA dehydrogenase activity
JI75_RS06755	COG1902	pentaerythritol trinitrate reductase activity
JI75_RS06755	COG0446	pyridine nucleotide-disulphide oxidoreductase
JI75_RS06775	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JI75_RS06780	COG1984	allophanate hydrolase subunit 2
JI75_RS06785	COG0511	ligase activity, forming carbon-carbon bonds
JI75_RS06790	COG0439	Biotin carboxylase
JI75_RS06795	COG4336	lyase activity
JI75_RS06800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JI75_RS06805	COG1914	H( )-stimulated, divalent metal cation uptake system
JI75_RS06810	COG0765	amino acid transport
JI75_RS06815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JI75_RS06820	COG2357	RelA SpoT domain protein
JI75_RS06825	COG3956	TIGRFAM MazG family protein
JI75_RS06835	COG0285	dihydrofolate synthase activity
JI75_RS06840	COG1573	uracil-dna glycosylase
JI75_RS06845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JI75_RS06850	COG0521	Mo-molybdopterin cofactor biosynthetic process
JI75_RS06855	COG0303	'Molybdopterin
JI75_RS06860	COG0148	phosphopyruvate hydratase activity
JI75_RS06875	COG0203	ribosomal protein L17
JI75_RS06880	COG0202	RNA polymerase activity
JI75_RS06890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JI75_RS06895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JI75_RS06905	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JI75_RS06910	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
JI75_RS06915	COG0644	oxidoreductase
JI75_RS06935	COG2271	Major facilitator Superfamily
JI75_RS06945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JI75_RS06960	COG2223	nitrite transmembrane transporter activity
JI75_RS06970	COG0039	L-malate dehydrogenase activity
JI75_RS06980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JI75_RS07010	COG0583	DNA-binding transcription factor activity
JI75_RS07015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JI75_RS07035	COG1120	ATPase activity
JI75_RS07060	COG0668	transmembrane transport
JI75_RS07075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JI75_RS07100	COG1138	Cytochrome C-type biogenesis protein
JI75_RS07135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JI75_RS07135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JI75_RS07145	COG4412	M6 family metalloprotease domain protein
JI75_RS07145	COG1404	Belongs to the peptidase S8 family
JI75_RS07155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JI75_RS07170	COG2848	UPF0210 protein
JI75_RS07175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JI75_RS07180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
JI75_RS07185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JI75_RS07200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JI75_RS07205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JI75_RS07210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JI75_RS07210	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JI75_RS07215	COG1959	2 iron, 2 sulfur cluster binding
JI75_RS07220	COG0396	ATPase activity
JI75_RS07225	COG0719	Fe-S assembly protein
JI75_RS07235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JI75_RS07240	COG0822	iron-sulfur transferase activity
JI75_RS07245	COG1979	alcohol dehydrogenase
JI75_RS07250	COG0789	Transcriptional regulator
JI75_RS07255	COG3381	protein complex oligomerization
JI75_RS07265	COG1131	(ABC) transporter
JI75_RS07270	COG1725	Transcriptional regulator
JI75_RS07285	COG1151	hydroxylamine reductase activity
JI75_RS07300	COG0488	(ABC) transporter
JI75_RS07305	COG1053	succinate dehydrogenase
JI75_RS07305	COG3976	FMN-binding domain protein
JI75_RS07315	COG0789	Transcriptional regulator
JI75_RS07325	COG0066	3-isopropylmalate dehydratase activity
JI75_RS07330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JI75_RS07340	COG0142	geranyltranstransferase activity
JI75_RS07350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JI75_RS07350	COG0248	Ppx GppA phosphatase
JI75_RS07370	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JI75_RS07370	COG1918	ferrous iron import across plasma membrane
JI75_RS07385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JI75_RS07480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JI75_RS07485	COG0495	leucyl-tRNA aminoacylation
JI75_RS07490	COG5002	protein histidine kinase activity
JI75_RS07495	COG0745	RESPONSE REGULATOR receiver
JI75_RS07500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JI75_RS07505	COG1696	Membrane protein involved in D-alanine export
JI75_RS07530	COG1053	succinate dehydrogenase
JI75_RS07535	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JI75_RS07545	COG3585	molybdate ion transport
JI75_RS07555	COG0569	domain protein
JI75_RS07555	COG0475	glutathione-regulated potassium exporter activity
JI75_RS07570	COG1115	amino acid carrier protein
JI75_RS07585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JI75_RS07590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JI75_RS07595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JI75_RS07615	COG5002	protein histidine kinase activity
JI75_RS07620	COG0745	RESPONSE REGULATOR receiver
JI75_RS07635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JI75_RS07640	COG0569	domain protein
JI75_RS07645	COG0569	domain protein
JI75_RS07665	COG1294	oxidase, subunit
JI75_RS07670	COG1271	oxidase subunit
JI75_RS07690	COG3475	LICD family
JI75_RS07695	COG0438	transferase activity, transferring glycosyl groups
JI75_RS07705	COG3475	LICD family
JI75_RS07715	COG0463	Glycosyl transferase, family 2
JI75_RS07725	COG0438	transferase activity, transferring glycosyl groups
JI75_RS07735	COG0298	carbon dioxide binding
JI75_RS07740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JI75_RS07745	COG0166	Belongs to the GPI family
JI75_RS07750	COG3279	Response regulator of the LytR AlgR family
JI75_RS07780	COG2832	Protein of unknown function (DUF454)
JI75_RS07785	COG0315	cyclic pyranopterin monophosphate synthase activity
JI75_RS07790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JI75_RS07795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JI75_RS07800	COG4149	molybdate abc transporter
JI75_RS07810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JI75_RS07815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JI75_RS07820	COG0736	holo-[acyl-carrier-protein] synthase activity
JI75_RS07840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JI75_RS07845	COG2233	PERMEase
JI75_RS07855	COG0640	Transcriptional regulator
JI75_RS07865	COG2217	Heavy metal translocating P-type atpase
JI75_RS07875	COG0222	ribosome binding
JI75_RS07880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JI75_RS07885	COG2197	response regulator
JI75_RS07890	COG3976	FMN-binding domain protein
JI75_RS07890	COG1053	succinate dehydrogenase
JI75_RS07890	COG0431	NADPH-dependent FMN reductase
JI75_RS07895	COG1477	protein flavinylation
JI75_RS07910	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JI75_RS07915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JI75_RS07945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JI75_RS07950	COG0826	peptidase U32
JI75_RS07955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JI75_RS07955	COG4499	WXG100 protein secretion system (Wss), protein YukC
JI75_RS07965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JI75_RS07970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JI75_RS07975	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JI75_RS07980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JI75_RS07990	COG4145	pantothenate transmembrane transporter activity
JI75_RS08005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JI75_RS08005	COG0072	phenylalanine-tRNA ligase activity
JI75_RS08010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JI75_RS08025	COG1216	Glycosyl transferase, family 2
JI75_RS08040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JI75_RS08045	COG3475	LICD family
JI75_RS08055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JI75_RS08060	COG1316	TRANSCRIPTIONal
JI75_RS08070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JI75_RS08080	COG1122	ATPase activity
JI75_RS08085	COG1122	ATPase activity
JI75_RS08095	COG0497	DNA recombination
JI75_RS08100	COG1490	D-aminoacyl-tRNA deacylase activity
JI75_RS08105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JI75_RS08110	COG2076	Multidrug Resistance protein
JI75_RS08115	COG2076	Multidrug Resistance protein
JI75_RS08120	COG0556	nucleotide-excision repair
JI75_RS08130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JI75_RS08130	COG2755	lipolytic protein G-D-S-L family
JI75_RS08160	COG0348	domain, Protein
JI75_RS08205	COG0860	N-Acetylmuramoyl-L-alanine amidase
JI75_RS08205	COG2247	cell wall binding repeat
JI75_RS08210	COG0539	negative regulation of cytoplasmic translation
JI75_RS08220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JI75_RS08240	COG0439	Biotin carboxylase
JI75_RS08245	COG5016	pyruvate
JI75_RS08245	COG0511	ligase activity, forming carbon-carbon bonds
JI75_RS08250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JI75_RS08260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JI75_RS08270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JI75_RS08275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JI75_RS08295	COG0516	GMP reductase activity
JI75_RS08295	COG0517	IMP dehydrogenase activity
JI75_RS08300	COG2197	response regulator
JI75_RS08305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JI75_RS08310	COG0549	Belongs to the carbamate kinase family
JI75_RS08315	COG1288	antiporter activity
JI75_RS08320	COG0733	neurotransmitter:sodium symporter activity
JI75_RS08325	COG1362	aminopeptidase activity
JI75_RS08330	COG1592	Rubrerythrin
JI75_RS08345	COG1960	acyl-CoA dehydrogenase activity
JI75_RS08355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JI75_RS08390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JI75_RS08405	COG0436	Aminotransferase
JI75_RS08415	COG2235	arginine
JI75_RS08430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JI75_RS08435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JI75_RS08440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JI75_RS08460	COG1763	Mo-molybdopterin cofactor biosynthetic process
JI75_RS08470	COG0437	4 iron, 4 sulfur cluster binding
JI75_RS08475	COG0243	molybdopterin cofactor binding
JI75_RS08485	COG0437	4 iron, 4 sulfur cluster binding
JI75_RS08490	COG2414	aldehyde ferredoxin oxidoreductase
JI75_RS08505	COG2197	response regulator
JI75_RS08510	COG1979	alcohol dehydrogenase
JI75_RS08515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JI75_RS08520	COG1316	TRANSCRIPTIONal
JI75_RS08530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JI75_RS08570	COG1199	ATP-dependent helicase activity
JI75_RS08580	COG1181	Belongs to the D-alanine--D-alanine ligase family
JI75_RS08590	COG1475	DNA binding
JI75_RS08595	COG1192	Involved in chromosome partitioning
JI75_RS08605	COG1847	R3H domain protein
JI75_RS08630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JI75_RS08635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JI75_RS08640	COG1309	transcriptional regulator
JI75_RS08685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JI75_RS08690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JI75_RS08710	COG0740	serine-type endopeptidase activity
JI75_RS08725	COG0789	Transcriptional regulator
JI75_RS08725	COG4978	Transcriptional regulator
JI75_RS08820	COG1216	Glycosyl transferase, family 2
JI75_RS08850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JI75_RS08880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JI75_RS08935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JI75_RS08950	COG0745	RESPONSE REGULATOR receiver
JI75_RS08975	COG0084	hydrolase, TatD family'
JI75_RS09025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JI75_RS09030	COG0594	ribonuclease P activity
JI75_RS09035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JI75_RS09045	COG2197	response regulator
JI75_RS09195	COG0006	proline dipeptidase activity
JI75_RS09215	COG3422	double-strand break repair
JI75_RS09230	COG0243	molybdopterin cofactor binding
JI75_RS09230	COG3383	formate dehydrogenase (NAD+) activity
JI75_RS09245	COG1442	glycosyl transferase family 8
JI75_RS09245	COG1216	Glycosyl transferase, family 2