locus-tag	class	description
BWI17_RS00010	COG0243	molybdopterin cofactor binding
BWI17_RS00020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWI17_RS00025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWI17_RS00030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BWI17_RS00050	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS00060	COG3008	intermembrane lipid transfer
BWI17_RS00060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BWI17_RS00075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWI17_RS00080	COG1136	(ABC) transporter
BWI17_RS00090	COG0577	efflux transmembrane transporter activity
BWI17_RS00100	COG1850	ribulose-bisphosphate carboxylase activity
BWI17_RS00105	COG0662	Cupin 2, conserved barrel domain protein
BWI17_RS00125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWI17_RS00145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWI17_RS00155	COG1024	Enoyl-CoA hydratase
BWI17_RS00160	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS00185	COG4771	TonB-dependent receptor
BWI17_RS00190	COG3386	PFAM SMP-30 Gluconolaconase
BWI17_RS00195	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS00205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWI17_RS00210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWI17_RS00220	COG0456	acetyltransferase
BWI17_RS00235	COG1346	cytolysis
BWI17_RS00245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BWI17_RS00250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BWI17_RS00285	COG1428	Deoxynucleoside kinase
BWI17_RS00295	COG0617	tRNA 3'-terminal CCA addition
BWI17_RS00305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BWI17_RS00310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BWI17_RS00330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BWI17_RS00335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BWI17_RS00350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWI17_RS00350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BWI17_RS00355	COG1511	domain protein
BWI17_RS00355	COG3264	Mechanosensitive ion channel
BWI17_RS00370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BWI17_RS00375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BWI17_RS00395	COG2003	Belongs to the UPF0758 family
BWI17_RS00400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BWI17_RS00405	COG0756	dUTP diphosphatase activity
BWI17_RS00445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BWI17_RS00480	COG0583	DNA-binding transcription factor activity
BWI17_RS00495	COG2267	carboxylic ester hydrolase activity
BWI17_RS00505	COG3132	Protein of unknown function, DUF480
BWI17_RS00520	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BWI17_RS00535	COG3852	Histidine kinase
BWI17_RS00550	COG2203	Gaf domain
BWI17_RS00550	COG3706	GGDEF domain
BWI17_RS00550	COG4251	negative regulation of phosphorylation
BWI17_RS00550	COG5001	Diguanylate cyclase
BWI17_RS00580	COG1335	isochorismatase
BWI17_RS00715	COG1074	ATP-dependent DNA helicase activity
BWI17_RS00725	COG1271	oxidase subunit
BWI17_RS00730	COG1294	oxidase, subunit
BWI17_RS00735	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BWI17_RS00745	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BWI17_RS00755	COG0254	rRNA binding
BWI17_RS00765	COG0247	lactate metabolic process
BWI17_RS00770	COG0625	glutathione transferase activity
BWI17_RS00775	COG0277	FAD linked oxidase domain protein
BWI17_RS00780	COG0277	FAD linked oxidase domain protein
BWI17_RS00785	COG0277	FAD linked oxidase domain protein
BWI17_RS00790	COG0784	Response regulator, receiver
BWI17_RS00800	COG5002	protein histidine kinase activity
BWI17_RS00820	COG2815	serine threonine protein kinase
BWI17_RS00820	COG0515	serine threonine protein kinase
BWI17_RS00830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BWI17_RS00880	COG1956	GAF domain-containing protein
BWI17_RS00885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BWI17_RS00890	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS00895	COG1280	lysine exporter protein (LysE YggA)
BWI17_RS00900	COG0678	peroxiredoxin activity
BWI17_RS00915	COG4260	virion core protein, lumpy skin disease virus
BWI17_RS00920	COG0633	Ferredoxin
BWI17_RS00920	COG3217	Mosc domain protein beta barrel domain protein
BWI17_RS00925	COG2363	Small membrane protein
BWI17_RS00960	COG0183	Belongs to the thiolase family
BWI17_RS00970	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWI17_RS00970	COG1024	Enoyl-CoA hydratase
BWI17_RS00980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BWI17_RS00985	COG2130	NADP-dependent
BWI17_RS00995	COG1022	Amp-dependent synthetase and ligase
BWI17_RS01000	COG0501	Belongs to the peptidase M48B family
BWI17_RS01005	COG4269	membrane
BWI17_RS01035	COG0183	Belongs to the thiolase family
BWI17_RS01040	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS01055	COG0726	polysaccharide deacetylase
BWI17_RS01065	COG0789	Transcriptional regulator
BWI17_RS01085	COG0330	HflC and HflK could
BWI17_RS01095	COG1832	CoA-binding protein
BWI17_RS01150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BWI17_RS01155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BWI17_RS01170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BWI17_RS01175	COG0793	Belongs to the peptidase S41A family
BWI17_RS01180	COG4942	peptidase
BWI17_RS01185	COG0588	phosphoglycerate mutase activity
BWI17_RS01200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BWI17_RS01210	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BWI17_RS01220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BWI17_RS01255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BWI17_RS01260	COG1040	competence protein
BWI17_RS01265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BWI17_RS01270	COG0156	8-amino-7-oxononanoate synthase activity
BWI17_RS01275	COG2267	carboxylic ester hydrolase activity
BWI17_RS01280	COG2226	methyltransferase
BWI17_RS01285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BWI17_RS01295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWI17_RS01300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWI17_RS01305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWI17_RS01305	COG1116	anion transmembrane transporter activity
BWI17_RS01310	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BWI17_RS01315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BWI17_RS01325	COG0494	nUDIX hydrolase
BWI17_RS01345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BWI17_RS01350	COG0456	acetyltransferase
BWI17_RS01355	COG0653	protein targeting
BWI17_RS01360	COG0739	heme binding
BWI17_RS01370	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BWI17_RS01380	COG1752	Esterase of the alpha-beta hydrolase superfamily
BWI17_RS01395	COG3064	Membrane
BWI17_RS01420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BWI17_RS01425	COG1181	Belongs to the D-alanine--D-alanine ligase family
BWI17_RS01430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BWI17_RS01435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWI17_RS01440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BWI17_RS01445	COG0772	Belongs to the SEDS family
BWI17_RS01450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BWI17_RS01455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BWI17_RS01460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BWI17_RS01465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BWI17_RS01480	COG0275	rRNA processing
BWI17_RS01485	COG2001	Belongs to the MraZ family
BWI17_RS01510	COG4106	trans-aconitate 2-methyltransferase activity
BWI17_RS01515	COG2850	peptidyl-arginine hydroxylation
BWI17_RS01540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BWI17_RS01580	COG0418	dihydroorotase activity
BWI17_RS01590	COG3107	peptidoglycan biosynthetic process
BWI17_RS01595	COG0792	nuclease activity
BWI17_RS01600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BWI17_RS01615	COG0300	oxidoreductase activity
BWI17_RS01635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BWI17_RS01655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BWI17_RS01660	COG0277	FAD linked oxidase domain protein
BWI17_RS01680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BWI17_RS01695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BWI17_RS01695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BWI17_RS01700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BWI17_RS01720	COG3409	Peptidoglycan-binding domain 1 protein
BWI17_RS01720	COG0793	Belongs to the peptidase S41A family
BWI17_RS01730	COG3384	dioxygenase
BWI17_RS01755	COG0745	RESPONSE REGULATOR receiver
BWI17_RS01770	COG2897	thiosulfate sulfurtransferase activity
BWI17_RS01775	COG1131	(ABC) transporter
BWI17_RS01785	COG0540	Belongs to the ATCase OTCase family
BWI17_RS01810	COG2197	response regulator
BWI17_RS01815	COG2202	Pas domain
BWI17_RS01815	COG2205	protein histidine kinase activity
BWI17_RS01835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWI17_RS01890	COG0583	DNA-binding transcription factor activity
BWI17_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS01915	COG4771	TonB-dependent receptor
BWI17_RS01940	COG2010	Cytochrome c
BWI17_RS01950	COG0784	Response regulator, receiver
BWI17_RS01950	COG2198	Histidine kinase
BWI17_RS01950	COG2205	protein histidine kinase activity
BWI17_RS02020	COG0745	RESPONSE REGULATOR receiver
BWI17_RS02030	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWI17_RS02040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWI17_RS02045	COG1278	Cold shock
BWI17_RS02070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWI17_RS02075	COG1609	Transcriptional regulator
BWI17_RS02085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWI17_RS02090	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS02095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWI17_RS02110	COG1653	transport
BWI17_RS02120	COG0395	ABC-type sugar transport system, permease component
BWI17_RS02125	COG3842	ATPase activity
BWI17_RS02130	COG0673	inositol 2-dehydrogenase activity
BWI17_RS02145	COG4452	Inner membrane protein CreD
BWI17_RS02150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWI17_RS02180	COG1690	Belongs to the RtcB family
BWI17_RS02190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BWI17_RS02205	COG1473	amidohydrolase
BWI17_RS02215	COG1408	metallophosphoesterase
BWI17_RS02325	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS02355	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BWI17_RS02405	COG1959	2 iron, 2 sulfur cluster binding
BWI17_RS02405	COG1295	ribonuclease BN
BWI17_RS02410	COG0515	serine threonine protein kinase
BWI17_RS02410	COG2815	serine threonine protein kinase
BWI17_RS02425	COG1252	NADH dehydrogenase
BWI17_RS02440	COG0667	Aldo Keto reductase
BWI17_RS02475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BWI17_RS02480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWI17_RS02490	COG0129	dihydroxy-acid dehydratase activity
BWI17_RS02495	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS02500	COG0673	inositol 2-dehydrogenase activity
BWI17_RS02515	COG0488	(ABC) transporter
BWI17_RS02540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BWI17_RS02560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BWI17_RS02565	COG3661	Belongs to the glycosyl hydrolase 67 family
BWI17_RS02575	COG1609	Transcriptional regulator
BWI17_RS02585	COG1175	transmembrane transport
BWI17_RS02590	COG0395	ABC-type sugar transport system, permease component
BWI17_RS02595	COG3842	ATPase activity
BWI17_RS02600	COG1070	Carbohydrate kinase
BWI17_RS02605	COG2115	Belongs to the xylose isomerase family
BWI17_RS02610	COG2115	Belongs to the xylose isomerase family
BWI17_RS02615	COG4213	ABC transporter substrate-binding protein
BWI17_RS02620	COG4214	carbohydrate transport
BWI17_RS02630	COG0667	Aldo Keto reductase
BWI17_RS02650	COG4948	Mandelate Racemase Muconate Lactonizing
BWI17_RS02655	COG3507	Belongs to the glycosyl hydrolase 43 family
BWI17_RS02665	COG1472	Belongs to the glycosyl hydrolase 3 family
BWI17_RS02695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWI17_RS02705	COG0602	queuosine metabolic process
BWI17_RS02735	COG1595	DNA-templated transcription, initiation
BWI17_RS02740	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BWI17_RS02770	COG1127	ABC transporter
BWI17_RS02775	COG5001	Diguanylate cyclase
BWI17_RS02775	COG5002	protein histidine kinase activity
BWI17_RS02775	COG3447	MASE1 domain protein
BWI17_RS02795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWI17_RS02815	COG0793	Belongs to the peptidase S41A family
BWI17_RS02825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWI17_RS02825	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BWI17_RS02835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BWI17_RS02885	COG0456	acetyltransferase
BWI17_RS02915	COG2329	Antibiotic biosynthesis monooxygenase
BWI17_RS02925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWI17_RS02930	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS02940	COG0513	Belongs to the DEAD box helicase family
BWI17_RS02945	COG0308	aminopeptidase N
BWI17_RS03000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BWI17_RS03005	COG4942	peptidase
BWI17_RS03010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BWI17_RS03015	COG0316	Belongs to the HesB IscA family
BWI17_RS03030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BWI17_RS03035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BWI17_RS03040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BWI17_RS03045	COG0628	permease
BWI17_RS03055	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BWI17_RS03065	COG0134	indole-3-glycerol-phosphate synthase activity
BWI17_RS03070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BWI17_RS03085	COG0546	phosphoglycolate phosphatase activity
BWI17_RS03090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BWI17_RS03095	COG2967	ApaG domain
BWI17_RS03100	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BWI17_RS03110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BWI17_RS03115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWI17_RS03120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWI17_RS03125	COG0006	proline dipeptidase activity
BWI17_RS03140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BWI17_RS03145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWI17_RS03150	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BWI17_RS03155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BWI17_RS03180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BWI17_RS03185	COG0751	glycine-tRNA ligase activity
BWI17_RS03190	COG0752	glycyl-tRNA synthetase alpha subunit
BWI17_RS03195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWI17_RS03200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BWI17_RS03205	COG4535	Mg2 and Co2 transporter CorC
BWI17_RS03210	COG0318	PFAM AMP-dependent synthetase and ligase
BWI17_RS03215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BWI17_RS03220	COG1702	phosphate starvation-inducible protein PhoH
BWI17_RS03230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWI17_RS03265	COG0012	GTP binding
BWI17_RS03270	COG0193	aminoacyl-tRNA hydrolase activity
BWI17_RS03275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BWI17_RS03280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BWI17_RS03290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BWI17_RS03305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWI17_RS03315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BWI17_RS03320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BWI17_RS03325	COG0742	ribosomal rna small subunit methyltransferase
BWI17_RS03335	COG2884	Cell division ATP-binding protein ftsE
BWI17_RS03350	COG1999	signal sequence binding
BWI17_RS03355	COG0109	protoheme IX farnesyltransferase activity
BWI17_RS03365	COG3346	SURF1 family
BWI17_RS03385	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BWI17_RS03405	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BWI17_RS03410	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BWI17_RS03415	COG0237	dephospho-CoA kinase activity
BWI17_RS03440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BWI17_RS03445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BWI17_RS03455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BWI17_RS03465	COG0725	ABC transporter, periplasmic molybdate-binding protein
BWI17_RS03470	COG4149	molybdate abc transporter
BWI17_RS03475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BWI17_RS03495	COG1910	domain protein
BWI17_RS03500	COG1305	Transglutaminase-like
BWI17_RS03515	COG2205	protein histidine kinase activity
BWI17_RS03520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BWI17_RS03525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWI17_RS03530	COG1120	ATPase activity
BWI17_RS03590	COG1476	TRANSCRIPTIONal
BWI17_RS03595	COG2226	methyltransferase
BWI17_RS03680	COG0346	lactoylglutathione lyase activity
BWI17_RS03845	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
BWI17_RS03945	COG0583	DNA-binding transcription factor activity
BWI17_RS03965	COG3001	Fructosamine kinase
BWI17_RS03970	COG0626	cystathionine gamma-synthase activity
BWI17_RS03985	COG2205	protein histidine kinase activity
BWI17_RS03990	COG0745	RESPONSE REGULATOR receiver
BWI17_RS04000	COG0628	permease
BWI17_RS04020	COG2823	Periplasmic or secreted lipoprotein
BWI17_RS04090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BWI17_RS04105	COG0129	dihydroxy-acid dehydratase activity
BWI17_RS04115	COG0612	Peptidase, M16
BWI17_RS04140	COG0667	Aldo Keto reductase
BWI17_RS04160	COG2814	Major facilitator Superfamily
BWI17_RS04190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BWI17_RS04200	COG1331	Highly conserved protein containing a thioredoxin domain
BWI17_RS04235	COG0411	ABC transporter
BWI17_RS04250	COG0515	serine threonine protein kinase
BWI17_RS04250	COG2815	serine threonine protein kinase
BWI17_RS04280	COG0408	coproporphyrinogen oxidase activity
BWI17_RS04290	COG0151	Belongs to the GarS family
BWI17_RS04295	COG0138	bifunctional purine biosynthesis protein purh
BWI17_RS04300	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BWI17_RS04315	COG4771	TonB-dependent receptor
BWI17_RS04320	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
BWI17_RS04325	COG0154	amidase activity
BWI17_RS04340	COG0444	Belongs to the ABC transporter superfamily
BWI17_RS04345	COG4608	Belongs to the ABC transporter superfamily
BWI17_RS04350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWI17_RS04355	COG0601	transmembrane transport
BWI17_RS04360	COG0747	negative chemotaxis
BWI17_RS04375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWI17_RS04385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWI17_RS04385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWI17_RS04395	COG0515	serine threonine protein kinase
BWI17_RS04395	COG2815	serine threonine protein kinase
BWI17_RS04445	COG0009	L-threonylcarbamoyladenylate synthase
BWI17_RS04470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BWI17_RS04480	COG0210	DNA helicase
BWI17_RS04490	COG1994	Peptidase M50
BWI17_RS04495	COG0495	leucyl-tRNA aminoacylation
BWI17_RS04510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BWI17_RS04515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BWI17_RS04520	COG0799	negative regulation of ribosome biogenesis
BWI17_RS04525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BWI17_RS04530	COG0424	maF-like protein
BWI17_RS04535	COG1530	ribonuclease E activity
BWI17_RS04575	COG1414	Transcriptional regulator
BWI17_RS04585	COG2045	Belongs to the ComB family
BWI17_RS04595	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS04600	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS04630	COG1024	Enoyl-CoA hydratase
BWI17_RS04630	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWI17_RS04635	COG0183	Belongs to the thiolase family
BWI17_RS04650	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS04655	COG0318	PFAM AMP-dependent synthetase and ligase
BWI17_RS04670	COG0762	integral membrane protein
BWI17_RS04700	COG2193	ferroxidase activity
BWI17_RS04720	COG0659	secondary active sulfate transmembrane transporter activity
BWI17_RS04740	COG1131	(ABC) transporter
BWI17_RS04750	COG1305	Transglutaminase-like
BWI17_RS04775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BWI17_RS04775	COG0475	glutathione-regulated potassium exporter activity
BWI17_RS04780	COG2249	NAD(P)H dehydrogenase (quinone) activity
BWI17_RS04785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BWI17_RS04790	COG3161	chorismate lyase activity
BWI17_RS04795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BWI17_RS04805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BWI17_RS04810	COG1758	RNA polymerase activity
BWI17_RS04815	COG0194	GDP metabolic process
BWI17_RS04820	COG1561	YicC-like family, N-terminal region
BWI17_RS04825	COG0515	serine threonine protein kinase
BWI17_RS04825	COG1357	PFAM Pentapeptide repeats (8 copies)
BWI17_RS04830	COG0631	protein serine/threonine phosphatase activity
BWI17_RS04835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BWI17_RS04840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BWI17_RS04845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BWI17_RS04855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BWI17_RS04865	COG2022	thiamine diphosphate biosynthetic process
BWI17_RS04880	COG3275	phosphorelay sensor kinase activity
BWI17_RS04910	COG1660	Displays ATPase and GTPase activities
BWI17_RS04915	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BWI17_RS04925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BWI17_RS04930	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BWI17_RS04935	COG1137	ATPase activity
BWI17_RS04940	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BWI17_RS04950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BWI17_RS05000	COG0859	PFAM glycosyl transferase family 9
BWI17_RS05010	COG1538	Outer membrane efflux protein
BWI17_RS05015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWI17_RS05020	COG0842	Transport permease protein
BWI17_RS05025	COG1131	(ABC) transporter
BWI17_RS05055	COG1968	undecaprenyl-diphosphatase activity
BWI17_RS05060	COG2267	carboxylic ester hydrolase activity
BWI17_RS05075	COG2198	Histidine kinase
BWI17_RS05075	COG0784	Response regulator, receiver
BWI17_RS05075	COG0643	Histidine kinase
BWI17_RS05080	COG0840	transmembrane signaling receptor activity
BWI17_RS05105	COG0351	phosphomethylpyrimidine kinase
BWI17_RS05110	COG0352	thiamine-phosphate diphosphorylase activity
BWI17_RS05115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BWI17_RS05120	COG3447	MASE1 domain protein
BWI17_RS05120	COG5002	protein histidine kinase activity
BWI17_RS05120	COG5001	Diguanylate cyclase
BWI17_RS05130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BWI17_RS05185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BWI17_RS05190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BWI17_RS05200	COG0747	negative chemotaxis
BWI17_RS05205	COG0601	transmembrane transport
BWI17_RS05210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWI17_RS05220	COG4608	Belongs to the ABC transporter superfamily
BWI17_RS05235	COG2204	response regulator
BWI17_RS05240	COG5000	phosphorelay sensor kinase activity
BWI17_RS05250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWI17_RS05255	COG0242	peptide deformylase activity
BWI17_RS05265	COG0758	DNA mediated transformation
BWI17_RS05290	COG0592	DNA-directed DNA polymerase activity
BWI17_RS05295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BWI17_RS05300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BWI17_RS05305	COG0594	ribonuclease P activity
BWI17_RS05310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BWI17_RS05315	COG0706	membrane insertase activity
BWI17_RS05320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BWI17_RS05340	COG0357	Ribosomal RNA small subunit methyltransferase G
BWI17_RS05345	COG1192	Involved in chromosome partitioning
BWI17_RS05350	COG1475	DNA binding
BWI17_RS05360	COG0356	it plays a direct role in the translocation of protons across the membrane
BWI17_RS05370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BWI17_RS05375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWI17_RS05380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BWI17_RS05385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BWI17_RS05390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BWI17_RS05395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BWI17_RS05400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWI17_RS05405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWI17_RS05430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BWI17_RS05450	COG0477	Major facilitator Superfamily
BWI17_RS05475	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS05480	COG1126	abc transporter atp-binding protein
BWI17_RS05485	COG0765	amino acid transport
BWI17_RS05490	COG4597	amino acid ABC transporter
BWI17_RS05495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWI17_RS05510	COG2010	Cytochrome c
BWI17_RS05510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BWI17_RS05515	COG2080	2 iron, 2 sulfur cluster binding
BWI17_RS05555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWI17_RS05565	COG3590	peptidase
BWI17_RS05570	COG0492	ferredoxin-NADP+ reductase activity
BWI17_RS05580	COG0488	(ABC) transporter
BWI17_RS05595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWI17_RS05610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BWI17_RS05615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWI17_RS05625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWI17_RS05635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWI17_RS05640	COG0300	oxidoreductase activity
BWI17_RS05660	COG0018	arginyl-trna synthetase
BWI17_RS05675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BWI17_RS05685	COG1073	alpha beta
BWI17_RS05695	COG0070	glutamate synthase
BWI17_RS05695	COG0067	glutamate synthase
BWI17_RS05695	COG0069	glutamate synthase activity
BWI17_RS05715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BWI17_RS05730	COG3307	-O-antigen
BWI17_RS05740	COG3245	cytochrome
BWI17_RS05745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BWI17_RS05760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWI17_RS05775	COG2264	protein methyltransferase activity
BWI17_RS05780	COG0439	Biotin carboxylase
BWI17_RS05785	COG0511	ligase activity, forming carbon-carbon bonds
BWI17_RS05790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWI17_RS05810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWI17_RS05825	COG2959	enzyme of heme biosynthesis
BWI17_RS05835	COG0181	hydroxymethylbilane synthase activity
BWI17_RS05840	COG1238	metal cluster binding
BWI17_RS05865	COG0189	ligase activity
BWI17_RS05885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWI17_RS05890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWI17_RS05900	COG3150	esterase
BWI17_RS05935	COG0415	Belongs to the DNA photolyase family
BWI17_RS05940	COG1678	Uncharacterized ACR, COG1678
BWI17_RS05945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BWI17_RS05950	COG1215	transferase activity, transferring glycosyl groups
BWI17_RS05955	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BWI17_RS05960	COG0540	Belongs to the ATCase OTCase family
BWI17_RS05970	COG0339	signal peptide processing
BWI17_RS05990	COG2204	response regulator
BWI17_RS05995	COG3852	Histidine kinase
BWI17_RS06005	COG0174	glutamine synthetase
BWI17_RS06010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BWI17_RS06015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BWI17_RS06020	COG2239	Acts as a magnesium transporter
BWI17_RS06035	COG0019	diaminopimelate decarboxylase activity
BWI17_RS06040	COG1965	Belongs to the frataxin family
BWI17_RS06050	COG0165	Argininosuccinate lyase
BWI17_RS06055	COG3275	phosphorelay sensor kinase activity
BWI17_RS06075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BWI17_RS06105	COG0321	lipoyl(octanoyl) transferase activity
BWI17_RS06110	COG2921	Belongs to the UPF0250 family
BWI17_RS06115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWI17_RS06120	COG1686	Belongs to the peptidase S11 family
BWI17_RS06130	COG0772	Belongs to the SEDS family
BWI17_RS06135	COG0768	penicillin binding
BWI17_RS06140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BWI17_RS06145	COG1792	Involved in formation and maintenance of cell shape
BWI17_RS06150	COG1077	Cell shape determining protein MreB Mrl
BWI17_RS06155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWI17_RS06160	COG0154	amidase activity
BWI17_RS06165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWI17_RS06175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BWI17_RS06180	COG0708	Exodeoxyribonuclease III
BWI17_RS06185	COG0488	(ABC) transporter
BWI17_RS06195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWI17_RS06200	COG2223	nitrite transmembrane transporter activity
BWI17_RS06210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWI17_RS06210	COG2813	Specifically methylates the guanine in position
BWI17_RS06215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWI17_RS06230	COG3604	Transcriptional regulator
BWI17_RS06315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWI17_RS06350	COG3300	MHYT domain
BWI17_RS06350	COG5001	Diguanylate cyclase
BWI17_RS06355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BWI17_RS06360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWI17_RS06375	COG2226	methyltransferase
BWI17_RS06385	COG2226	methyltransferase
BWI17_RS06395	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWI17_RS06400	COG3657	addiction module killer protein
BWI17_RS06435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWI17_RS06440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWI17_RS06460	COG2814	Major facilitator Superfamily
BWI17_RS06470	COG2815	serine threonine protein kinase
BWI17_RS06470	COG0515	serine threonine protein kinase
BWI17_RS06475	COG0596	Alpha beta hydrolase
BWI17_RS06485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BWI17_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS06510	COG3119	arylsulfatase activity
BWI17_RS06525	COG0395	ABC-type sugar transport system, permease component
BWI17_RS06530	COG1175	transmembrane transport
BWI17_RS06535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWI17_RS06545	COG3842	ATPase activity
BWI17_RS06565	COG3275	phosphorelay sensor kinase activity
BWI17_RS06575	COG1538	Outer membrane efflux protein
BWI17_RS06580	COG1566	PFAM secretion protein HlyD family protein
BWI17_RS06590	COG3275	phosphorelay sensor kinase activity
BWI17_RS06600	COG2972	Histidine kinase
BWI17_RS06635	COG2945	thiolester hydrolase activity
BWI17_RS06670	COG4232	protein-disulfide reductase activity
BWI17_RS06675	COG1981	membrane
BWI17_RS06680	COG1770	oligopeptidase
BWI17_RS06700	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS06735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWI17_RS06760	COG1414	Transcriptional regulator
BWI17_RS06765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BWI17_RS06780	COG1012	belongs to the aldehyde dehydrogenase family
BWI17_RS06785	COG0028	Belongs to the TPP enzyme family
BWI17_RS06795	COG1309	transcriptional regulator
BWI17_RS06800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWI17_RS06810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWI17_RS06815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BWI17_RS06820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BWI17_RS06835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BWI17_RS06840	COG0459	protein refolding
BWI17_RS06895	COG1131	(ABC) transporter
BWI17_RS06900	COG1725	Transcriptional regulator
BWI17_RS06940	COG0204	Acyl-transferase
BWI17_RS06965	COG3011	Protein conserved in bacteria
BWI17_RS06970	COG0667	Aldo Keto reductase
BWI17_RS06980	COG2081	HI0933 family
BWI17_RS06995	COG2951	lytic endotransglycosylase activity
BWI17_RS07010	COG2205	protein histidine kinase activity
BWI17_RS07015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWI17_RS07020	COG1741	Belongs to the pirin family
BWI17_RS07040	COG0457	Tetratricopeptide repeat
BWI17_RS07060	COG4575	ribosome binding
BWI17_RS07065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BWI17_RS07065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BWI17_RS07095	COG1247	-acetyltransferase
BWI17_RS07100	COG1764	response to oxidative stress
BWI17_RS07105	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BWI17_RS07125	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS07130	COG0210	DNA helicase
BWI17_RS07135	COG3593	DNA synthesis involved in DNA repair
BWI17_RS07135	COG3593	DNA synthesis involved in DNA repair
BWI17_RS07175	COG0584	glycerophosphoryl diester phosphodiesterase
BWI17_RS07185	COG1942	4-Oxalocrotonate Tautomerase
BWI17_RS07210	COG1695	Transcriptional regulator
BWI17_RS07305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BWI17_RS07320	COG1953	Uracil, thiamine, allantoin
BWI17_RS07335	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS07350	COG3386	PFAM SMP-30 Gluconolaconase
BWI17_RS07370	COG1609	Transcriptional regulator
BWI17_RS07375	COG3180	Ammonia monooxygenase
BWI17_RS07390	COG1234	tRNA 3'-trailer cleavage
BWI17_RS07395	COG2770	Histidine kinase
BWI17_RS07395	COG2208	phosphoserine phosphatase activity
BWI17_RS07400	COG2885	chlorophyll binding
BWI17_RS07425	COG3483	tryptophan 2,3-dioxygenase activity
BWI17_RS07445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWI17_RS07480	COG4536	flavin adenine dinucleotide binding
BWI17_RS07485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWI17_RS07490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BWI17_RS07500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWI17_RS07510	COG0228	four-way junction DNA binding
BWI17_RS07515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BWI17_RS07520	COG0336	Belongs to the RNA methyltransferase TrmD family
BWI17_RS07525	COG0335	large ribosomal subunit rRNA binding
BWI17_RS07530	COG2321	neutral zinc metallopeptidase
BWI17_RS07540	COG1609	Transcriptional regulator
BWI17_RS07545	COG2721	sulfolactate sulfo-lyase activity
BWI17_RS07550	COG2721	sulfolactate sulfo-lyase activity
BWI17_RS07555	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS07560	COG2855	membrane
BWI17_RS07600	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BWI17_RS07620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BWI17_RS07635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BWI17_RS07645	COG0745	RESPONSE REGULATOR receiver
BWI17_RS07660	COG0823	Involved in the tonB-independent uptake of proteins
BWI17_RS07660	COG1506	peptidase
BWI17_RS07745	COG0142	geranyltranstransferase activity
BWI17_RS07755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BWI17_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS07785	COG0625	glutathione transferase activity
BWI17_RS07790	COG1902	pentaerythritol trinitrate reductase activity
BWI17_RS07810	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS07875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWI17_RS07890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWI17_RS07910	COG1280	lysine exporter protein (LysE YggA)
BWI17_RS07915	COG1473	amidohydrolase
BWI17_RS07925	COG2814	Major facilitator Superfamily
BWI17_RS07935	COG2814	Major facilitator Superfamily
BWI17_RS07955	COG0347	Belongs to the P(II) protein family
BWI17_RS07960	COG0004	ammonium transporteR
BWI17_RS07975	COG3209	COG3209 Rhs family protein
BWI17_RS07995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BWI17_RS08000	COG1459	type II secretion system
BWI17_RS08005	COG2165	general secretion pathway protein
BWI17_RS08015	COG2165	general secretion pathway protein
BWI17_RS08025	COG3156	type II secretion system protein K
BWI17_RS08045	COG1450	Type ii and iii secretion system protein
BWI17_RS08135	COG0438	transferase activity, transferring glycosyl groups
BWI17_RS08140	COG1132	(ABC) transporter
BWI17_RS08145	COG0438	transferase activity, transferring glycosyl groups
BWI17_RS08160	COG2226	methyltransferase
BWI17_RS08175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BWI17_RS08180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWI17_RS08205	COG3510	cephalosporin hydroxylase
BWI17_RS08210	COG4206	TonB-dependent receptor
BWI17_RS08230	COG0730	response to heat
BWI17_RS08240	COG1253	flavin adenine dinucleotide binding
BWI17_RS08265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BWI17_RS08280	COG4946	Tricorn protease homolog
BWI17_RS08280	COG1506	peptidase
BWI17_RS08280	COG0823	Involved in the tonB-independent uptake of proteins
BWI17_RS08300	COG0469	pyruvate kinase activity
BWI17_RS08310	COG0126	phosphoglycerate kinase activity
BWI17_RS08320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BWI17_RS08330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BWI17_RS08335	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BWI17_RS08340	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BWI17_RS08350	COG0754	glutathionylspermidine amidase activity
BWI17_RS08360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BWI17_RS08365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BWI17_RS08365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BWI17_RS08370	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BWI17_RS08375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BWI17_RS08380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWI17_RS08385	COG0859	PFAM glycosyl transferase family 9
BWI17_RS08385	COG0457	Tetratricopeptide repeat
BWI17_RS08395	COG5487	UPF0391 membrane protein
BWI17_RS08410	COG4969	Belongs to the N-Me-Phe pilin family
BWI17_RS08445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BWI17_RS08450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BWI17_RS08455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BWI17_RS08460	COG0196	riboflavin kinase activity
BWI17_RS08470	COG0268	Binds directly to 16S ribosomal RNA
BWI17_RS08475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWI17_RS08480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BWI17_RS08490	COG0137	argininosuccinate synthase activity
BWI17_RS08500	COG0505	Belongs to the CarA family
BWI17_RS08505	COG3577	Aspartyl protease
BWI17_RS08510	COG1469	GTP cyclohydrolase I activity
BWI17_RS08540	COG1459	type II secretion system
BWI17_RS08545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BWI17_RS08560	COG3409	Peptidoglycan-binding domain 1 protein
BWI17_RS08560	COG3267	Type II secretory pathway component ExeA
BWI17_RS08570	COG1127	ABC transporter
BWI17_RS08575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BWI17_RS08580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BWI17_RS08585	COG2854	intermembrane phospholipid transfer
BWI17_RS08595	COG1131	(ABC) transporter
BWI17_RS08600	COG0842	Transport permease protein
BWI17_RS08605	COG0271	Belongs to the BolA IbaG family
BWI17_RS08610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BWI17_RS08615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BWI17_RS08620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BWI17_RS08625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWI17_RS08630	COG0131	Imidazoleglycerol-phosphate dehydratase
BWI17_RS08635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BWI17_RS08640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BWI17_RS08650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BWI17_RS08655	COG0140	phosphoribosyl-ATP diphosphatase activity
BWI17_RS08660	COG0537	adenosine 5'-monophosphoramidase activity
BWI17_RS08665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWI17_RS08670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWI17_RS08675	COG0805	protein transport
BWI17_RS08690	COG0723	plastoquinol--plastocyanin reductase activity
BWI17_RS08695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BWI17_RS08700	COG2857	Cytochrome c1
BWI17_RS08705	COG0625	glutathione transferase activity
BWI17_RS08710	COG2969	positive regulation of protein catabolic process
BWI17_RS08750	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BWI17_RS08760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BWI17_RS08765	COG0081	regulation of translation
BWI17_RS08770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BWI17_RS08775	COG0222	ribosome binding
BWI17_RS08780	COG0085	RNA polymerase activity
BWI17_RS08785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BWI17_RS08790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BWI17_RS08795	COG0049	tRNA binding
BWI17_RS08800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BWI17_RS08810	COG0051	transcription antitermination factor activity, RNA binding
BWI17_RS08815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BWI17_RS08820	COG0088	Forms part of the polypeptide exit tunnel
BWI17_RS08825	COG0089	rRNA binding
BWI17_RS08830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BWI17_RS08835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BWI17_RS08840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BWI17_RS08850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BWI17_RS08855	COG0255	Belongs to the universal ribosomal protein uL29 family
BWI17_RS08860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BWI17_RS08865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BWI17_RS08870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BWI17_RS08875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BWI17_RS08890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BWI17_RS08895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BWI17_RS08900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BWI17_RS08910	COG0200	Binds to the 23S rRNA
BWI17_RS08915	COG0201	protein transport
BWI17_RS08920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BWI17_RS08925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BWI17_RS08930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BWI17_RS08940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BWI17_RS08945	COG0202	RNA polymerase activity
BWI17_RS08950	COG0203	ribosomal protein L17
BWI17_RS08980	COG2814	Major facilitator Superfamily
BWI17_RS08985	COG0629	single-stranded DNA binding
BWI17_RS08990	COG0501	Belongs to the peptidase M48B family
BWI17_RS09010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BWI17_RS09015	COG1446	asparaginase
BWI17_RS09020	COG0494	nUDIX hydrolase
BWI17_RS09025	COG3568	Endonuclease Exonuclease Phosphatase
BWI17_RS09030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BWI17_RS09035	COG0071	Belongs to the small heat shock protein (HSP20) family
BWI17_RS09040	COG1595	DNA-templated transcription, initiation
BWI17_RS09060	COG3220	belongs to the UPF0276 family
BWI17_RS09080	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BWI17_RS09085	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BWI17_RS09095	COG0523	cobalamin synthesis protein
BWI17_RS09100	COG0523	cobalamin synthesis protein
BWI17_RS09105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BWI17_RS09115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BWI17_RS09120	COG1560	Kdo2-lipid A biosynthetic process
BWI17_RS09125	COG0702	epimerase
BWI17_RS09135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BWI17_RS09145	COG0625	glutathione transferase activity
BWI17_RS09150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BWI17_RS09170	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BWI17_RS09195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BWI17_RS09200	COG0037	tRNA processing
BWI17_RS09215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BWI17_RS09220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BWI17_RS09225	COG2358	TRAP transporter, solute receptor (TAXI family
BWI17_RS09245	COG0739	heme binding
BWI17_RS09245	COG0741	lytic transglycosylase activity
BWI17_RS09245	COG1196	nuclear chromosome segregation
BWI17_RS09250	COG0861	Integral membrane protein TerC family
BWI17_RS09285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWI17_RS09295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWI17_RS09325	COG2423	ornithine cyclodeaminase activity
BWI17_RS09330	COG2815	serine threonine protein kinase
BWI17_RS09330	COG0515	serine threonine protein kinase
BWI17_RS09340	COG0045	succinate-CoA ligase (ADP-forming) activity
BWI17_RS09345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BWI17_RS09355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWI17_RS09365	COG3383	formate dehydrogenase (NAD+) activity
BWI17_RS09415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWI17_RS09420	COG3622	Belongs to the hyi family
BWI17_RS09430	COG5265	(ABC) transporter
BWI17_RS09435	COG2815	serine threonine protein kinase
BWI17_RS09435	COG0515	serine threonine protein kinase
BWI17_RS09455	COG1686	Belongs to the peptidase S11 family
BWI17_RS09460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BWI17_RS09465	COG0247	lactate metabolic process
BWI17_RS09475	COG1556	Lactate utilization protein
BWI17_RS09485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BWI17_RS09500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWI17_RS09505	COG2084	Dehydrogenase
BWI17_RS09510	COG0625	glutathione transferase activity
BWI17_RS09555	COG2205	protein histidine kinase activity
BWI17_RS09555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWI17_RS09560	COG1643	Atp-dependent helicase
BWI17_RS09570	COG2259	Doxx family
BWI17_RS09580	COG0583	DNA-binding transcription factor activity
BWI17_RS09600	COG4608	Belongs to the ABC transporter superfamily
BWI17_RS09605	COG0444	Belongs to the ABC transporter superfamily
BWI17_RS09620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWI17_RS09625	COG0601	transmembrane transport
BWI17_RS09630	COG0747	negative chemotaxis
BWI17_RS09635	COG0747	negative chemotaxis
BWI17_RS09660	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BWI17_RS09670	COG3186	Phenylalanine-4-hydroxylase
BWI17_RS09685	COG0747	negative chemotaxis
BWI17_RS09695	COG4221	oxidoreductase activity
BWI17_RS09720	COG0747	negative chemotaxis
BWI17_RS09735	COG0545	Peptidyl-prolyl cis-trans isomerase
BWI17_RS09740	COG1881	PFAM PEBP family protein
BWI17_RS09745	COG1058	Belongs to the CinA family
BWI17_RS09745	COG1546	Belongs to the CinA family
BWI17_RS09760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BWI17_RS09765	COG2815	serine threonine protein kinase
BWI17_RS09765	COG0515	serine threonine protein kinase
BWI17_RS09780	COG0596	Alpha beta hydrolase
BWI17_RS09785	COG0473	3-isopropylmalate dehydrogenase activity
BWI17_RS09835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWI17_RS09840	COG0583	DNA-binding transcription factor activity
BWI17_RS09845	COG1741	Belongs to the pirin family
BWI17_RS09850	COG2259	Doxx family
BWI17_RS09865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWI17_RS09870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BWI17_RS09870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BWI17_RS09870	COG0506	proline dehydrogenase activity
BWI17_RS09890	COG0735	belongs to the Fur family
BWI17_RS09895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWI17_RS09900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BWI17_RS09905	COG0505	Belongs to the CarA family
BWI17_RS09910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BWI17_RS09915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BWI17_RS09920	COG1534	Rna-binding protein
BWI17_RS09925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BWI17_RS09930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWI17_RS09940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWI17_RS09970	COG0149	triose-phosphate isomerase activity
BWI17_RS09985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWI17_RS09990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWI17_RS09995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWI17_RS10000	COG0649	NAD binding
BWI17_RS10010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BWI17_RS10015	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BWI17_RS10020	COG1034	ATP synthesis coupled electron transport
BWI17_RS10025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BWI17_RS10030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWI17_RS10040	COG0713	ATP synthesis coupled electron transport
BWI17_RS10055	COG1007	ATP synthesis coupled electron transport
BWI17_RS10075	COG0598	Magnesium transport protein CorA
BWI17_RS10085	COG0166	Belongs to the GPI family
BWI17_RS10105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWI17_RS10110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWI17_RS10120	COG0251	oxidation-reduction process
BWI17_RS10150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWI17_RS10160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BWI17_RS10190	COG1595	DNA-templated transcription, initiation
BWI17_RS10195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BWI17_RS10210	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BWI17_RS10230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWI17_RS10235	COG3416	Protein conserved in bacteria
BWI17_RS10235	COG2943	transferase activity, transferring hexosyl groups
BWI17_RS10240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BWI17_RS10245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BWI17_RS10250	COG0504	CTP synthase activity
BWI17_RS10255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BWI17_RS10260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BWI17_RS10270	COG0456	acetyltransferase
BWI17_RS10270	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BWI17_RS10280	COG1470	cell adhesion involved in biofilm formation
BWI17_RS10280	COG0366	Alpha amylase catalytic
BWI17_RS10330	COG3258	Cytochrome c
BWI17_RS10375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BWI17_RS10410	COG0148	phosphopyruvate hydratase activity
BWI17_RS10415	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BWI17_RS10435	COG2095	MarC family integral membrane protein
BWI17_RS10450	COG0387	Pfam Sodium calcium exchanger
BWI17_RS10455	COG3158	transport of potassium into the cell
BWI17_RS10460	COG2205	protein histidine kinase activity
BWI17_RS10465	COG0745	RESPONSE REGULATOR receiver
BWI17_RS10485	COG1295	ribonuclease BN
BWI17_RS10530	COG0438	transferase activity, transferring glycosyl groups
BWI17_RS10550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BWI17_RS10610	COG5001	Diguanylate cyclase
BWI17_RS10610	COG3300	MHYT domain
BWI17_RS10645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BWI17_RS10650	COG0802	atpase or kinase
BWI17_RS10655	COG0860	N-Acetylmuramoyl-L-alanine amidase
BWI17_RS10665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BWI17_RS10680	COG1570	exodeoxyribonuclease VII activity
BWI17_RS10695	COG1663	tetraacyldisaccharide 4'-kinase activity
BWI17_RS10700	COG2835	tetraacyldisaccharide 4'-kinase activity
BWI17_RS10705	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BWI17_RS10710	COG0563	adenylate kinase activity
BWI17_RS10715	COG0205	6-phosphofructokinase activity
BWI17_RS10720	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BWI17_RS10725	COG0840	transmembrane signaling receptor activity
BWI17_RS10740	COG1858	cytochrome C peroxidase
BWI17_RS10745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWI17_RS10755	COG0343	queuine tRNA-ribosyltransferase activity
BWI17_RS10765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BWI17_RS10770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BWI17_RS10775	COG0586	Pfam SNARE associated Golgi protein
BWI17_RS10795	COG1295	ribonuclease BN
BWI17_RS10795	COG1959	2 iron, 2 sulfur cluster binding
BWI17_RS10810	COG0741	lytic transglycosylase activity
BWI17_RS10820	COG0442	prolyl-tRNA aminoacylation
BWI17_RS10825	COG0494	nUDIX hydrolase
BWI17_RS10835	COG1819	glycosyl
BWI17_RS10845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BWI17_RS10850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BWI17_RS10860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BWI17_RS10865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BWI17_RS10870	COG0142	geranyltranstransferase activity
BWI17_RS10890	COG0745	RESPONSE REGULATOR receiver
BWI17_RS10895	COG2205	protein histidine kinase activity
BWI17_RS10980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BWI17_RS10980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWI17_RS11015	COG3507	Belongs to the glycosyl hydrolase 43 family
BWI17_RS11065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BWI17_RS11080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BWI17_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS11110	COG0411	ABC transporter
BWI17_RS11120	COG0559	Belongs to the binding-protein-dependent transport system permease family
BWI17_RS11140	COG0318	PFAM AMP-dependent synthetase and ligase
BWI17_RS11150	COG2272	Belongs to the type-B carboxylesterase lipase family
BWI17_RS11155	COG0583	DNA-binding transcription factor activity
BWI17_RS11165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BWI17_RS11170	COG0165	Argininosuccinate lyase
BWI17_RS11180	COG0297	glycogen (starch) synthase activity
BWI17_RS11185	COG1733	regulation of RNA biosynthetic process
BWI17_RS11200	COG1024	Enoyl-CoA hydratase
BWI17_RS11205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWI17_RS11210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BWI17_RS11235	COG1522	sequence-specific DNA binding
BWI17_RS11265	COG2194	sulfuric ester hydrolase activity
BWI17_RS11300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWI17_RS11305	COG1126	abc transporter atp-binding protein
BWI17_RS11310	COG0765	amino acid transport
BWI17_RS11315	COG0765	amino acid transport
BWI17_RS11320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWI17_RS11340	COG0697	spore germination
BWI17_RS11360	COG3710	Transcriptional regulator
BWI17_RS11360	COG0457	Tetratricopeptide repeat
BWI17_RS11370	COG1678	Uncharacterized ACR, COG1678
BWI17_RS11390	COG0642	Histidine kinase
BWI17_RS11395	COG0745	RESPONSE REGULATOR receiver
BWI17_RS11405	COG1309	transcriptional regulator
BWI17_RS11420	COG0534	Mate efflux family protein
BWI17_RS11425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWI17_RS11440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BWI17_RS11470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWI17_RS11475	COG1309	transcriptional regulator
BWI17_RS11500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BWI17_RS11525	COG3279	Response regulator of the LytR AlgR family
BWI17_RS11530	COG3275	phosphorelay sensor kinase activity
BWI17_RS11545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWI17_RS11560	COG3795	YCII-related domain
BWI17_RS11570	COG3795	YCII-related domain
BWI17_RS11580	COG4941	Belongs to the sigma-70 factor family
BWI17_RS11585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BWI17_RS11590	COG0583	DNA-binding transcription factor activity
BWI17_RS11595	COG4681	YaeQ
BWI17_RS11630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWI17_RS11635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BWI17_RS11650	COG0017	Asparaginyl-tRNA synthetase
BWI17_RS11660	COG4251	negative regulation of phosphorylation
BWI17_RS11665	COG3920	Histidine kinase
BWI17_RS11675	COG1278	Cold shock
BWI17_RS11680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWI17_RS11730	COG2268	Band 7 protein
BWI17_RS11770	COG2823	Periplasmic or secreted lipoprotein
BWI17_RS11785	COG3237	CsbD-like
BWI17_RS11790	COG3459	Glycosyltransferase 36 associated
BWI17_RS11810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWI17_RS11845	COG1131	(ABC) transporter
BWI17_RS11850	COG0842	Transport permease protein
BWI17_RS11855	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BWI17_RS11860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BWI17_RS11885	COG0583	DNA-binding transcription factor activity
BWI17_RS11890	COG0322	excinuclease ABC activity
BWI17_RS11895	COG2135	peptidase activity
BWI17_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS11990	COG3540	Alkaline phosphatase
BWI17_RS11995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BWI17_RS12010	COG0861	Integral membrane protein TerC family
BWI17_RS12020	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BWI17_RS12025	COG0154	amidase activity
BWI17_RS12040	COG1940	carbohydrate kinase activity
BWI17_RS12045	COG3647	Membrane
BWI17_RS12050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWI17_RS12060	COG2353	YceI-like domain
BWI17_RS12075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BWI17_RS12090	COG1132	(ABC) transporter
BWI17_RS12140	COG1230	cation diffusion facilitator family transporter
BWI17_RS12170	COG0625	glutathione transferase activity
BWI17_RS12195	COG2050	protein possibly involved in aromatic compounds catabolism
BWI17_RS12200	COG0625	glutathione transferase activity
BWI17_RS12210	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS12220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BWI17_RS12220	COG2190	(PTS) system
BWI17_RS12220	COG1263	PTS System
BWI17_RS12225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BWI17_RS12225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWI17_RS12230	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BWI17_RS12240	COG2188	Transcriptional regulator
BWI17_RS12245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BWI17_RS12250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BWI17_RS12255	COG1376	ErfK ybiS ycfS ynhG family protein
BWI17_RS12290	COG0243	molybdopterin cofactor binding
BWI17_RS12295	COG1073	alpha beta
BWI17_RS12305	COG0456	acetyltransferase
BWI17_RS12320	COG0346	lactoylglutathione lyase activity
BWI17_RS12325	COG4251	negative regulation of phosphorylation
BWI17_RS12400	COG0429	hydrolase of the alpha beta-hydrolase fold
BWI17_RS12465	COG4948	Mandelate Racemase Muconate Lactonizing
BWI17_RS12470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWI17_RS12480	COG4166	transmembrane transport
BWI17_RS12520	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS12570	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BWI17_RS12585	COG0312	modulator of DNA gyrase
BWI17_RS12595	COG0463	Glycosyl transferase, family 2
BWI17_RS12630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWI17_RS12635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWI17_RS12650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BWI17_RS12655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BWI17_RS12660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BWI17_RS12665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BWI17_RS12675	COG1595	DNA-templated transcription, initiation
BWI17_RS12680	COG2096	Adenosyltransferase
BWI17_RS12685	COG0825	malonyl-CoA metabolic process
BWI17_RS12690	COG0037	tRNA processing
BWI17_RS12695	COG0105	UTP biosynthetic process
BWI17_RS12700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BWI17_RS12715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BWI17_RS12720	COG0124	histidyl-tRNA synthetase
BWI17_RS12735	COG1160	GTP binding
BWI17_RS12740	COG1923	regulation of RNA biosynthetic process
BWI17_RS12745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BWI17_RS12750	COG0330	HflC and HflK could
BWI17_RS12755	COG0330	HflC and HflK could
BWI17_RS12765	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BWI17_RS12770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BWI17_RS12780	COG0557	exoribonuclease II activity
BWI17_RS12785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BWI17_RS12795	COG0612	Peptidase, M16
BWI17_RS12810	COG0360	Binds together with S18 to 16S ribosomal RNA
BWI17_RS12820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BWI17_RS12825	COG0359	binds to the 23S rRNA
BWI17_RS12835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BWI17_RS12845	COG2815	serine threonine protein kinase
BWI17_RS12845	COG0515	serine threonine protein kinase
BWI17_RS12860	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS12865	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BWI17_RS12870	COG1562	ergosterol biosynthetic process
BWI17_RS12875	COG1562	ergosterol biosynthetic process
BWI17_RS12885	COG0544	peptidyl-prolyl cis-trans isomerase activity
BWI17_RS12890	COG0740	serine-type endopeptidase activity
BWI17_RS12895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BWI17_RS12900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWI17_RS12920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWI17_RS12940	COG4166	transmembrane transport
BWI17_RS12945	COG0601	transmembrane transport
BWI17_RS12950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWI17_RS12960	COG0339	signal peptide processing
BWI17_RS12970	COG0515	serine threonine protein kinase
BWI17_RS12970	COG2815	serine threonine protein kinase
BWI17_RS13060	COG0741	lytic transglycosylase activity
BWI17_RS13060	COG1388	LysM domain
BWI17_RS13140	COG3279	Response regulator of the LytR AlgR family
BWI17_RS13145	COG3275	phosphorelay sensor kinase activity
BWI17_RS13155	COG3903	Transcriptional regulator
BWI17_RS13155	COG3629	intracellular signal transduction
BWI17_RS13170	COG5002	protein histidine kinase activity
BWI17_RS13180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWI17_RS13190	COG0328	RNA-DNA hybrid ribonuclease activity
BWI17_RS13200	COG5001	Diguanylate cyclase
BWI17_RS13200	COG5002	protein histidine kinase activity
BWI17_RS13220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BWI17_RS13225	COG2878	Part of a membrane complex involved in electron transport
BWI17_RS13230	COG0686	Belongs to the AlaDH PNT family
BWI17_RS13235	COG0167	dihydroorotate dehydrogenase activity
BWI17_RS13240	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BWI17_RS13245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BWI17_RS13260	COG0450	alkyl hydroperoxide reductase
BWI17_RS13275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BWI17_RS13280	COG4208	sulfate ABC transporter
BWI17_RS13290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BWI17_RS13305	COG0175	sulfate reduction
BWI17_RS13310	COG0175	sulfate reduction
BWI17_RS13320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWI17_RS13325	COG0583	DNA-binding transcription factor activity
BWI17_RS13345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWI17_RS13350	COG1309	transcriptional regulator
BWI17_RS13390	COG0746	molybdenum cofactor guanylyltransferase activity
BWI17_RS13395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BWI17_RS13400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BWI17_RS13435	COG0437	4 iron, 4 sulfur cluster binding
BWI17_RS13445	COG2864	formate dehydrogenase
BWI17_RS13455	COG2032	superoxide dismutase activity
BWI17_RS13470	COG3005	denitrification pathway
BWI17_RS13495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BWI17_RS13530	COG0741	lytic transglycosylase activity
BWI17_RS13530	COG1196	nuclear chromosome segregation
BWI17_RS13530	COG0739	heme binding
BWI17_RS13535	COG0515	serine threonine protein kinase
BWI17_RS13550	COG1216	Glycosyl transferase, family 2
BWI17_RS13550	COG0438	transferase activity, transferring glycosyl groups
BWI17_RS13620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWI17_RS13625	COG0402	S-adenosylhomocysteine deaminase activity
BWI17_RS13640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BWI17_RS13645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWI17_RS13655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWI17_RS13660	COG0287	Prephenate dehydrogenase
BWI17_RS13665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BWI17_RS13670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BWI17_RS13680	COG0776	regulation of translation
BWI17_RS13690	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BWI17_RS13695	COG0284	orotidine-5'-phosphate decarboxylase activity
BWI17_RS13705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BWI17_RS13710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWI17_RS13720	COG1596	polysaccharide export
BWI17_RS13720	COG1555	photosystem II stabilization
BWI17_RS13765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BWI17_RS13770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BWI17_RS13780	COG3548	integral membrane protein
BWI17_RS13785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWI17_RS13785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWI17_RS13790	COG0463	Glycosyl transferase, family 2
BWI17_RS13800	COG2076	Multidrug Resistance protein
BWI17_RS13805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BWI17_RS13810	COG1193	negative regulation of DNA recombination
BWI17_RS13815	COG0492	ferredoxin-NADP+ reductase activity
BWI17_RS13825	COG1674	ftsk spoiiie
BWI17_RS13830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BWI17_RS13835	COG0564	pseudouridine synthase activity
BWI17_RS13840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BWI17_RS13845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BWI17_RS13850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BWI17_RS13865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BWI17_RS13870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BWI17_RS13875	COG0406	alpha-ribazole phosphatase activity
BWI17_RS13880	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BWI17_RS13885	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BWI17_RS13890	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BWI17_RS13895	COG2815	serine threonine protein kinase
BWI17_RS13895	COG0515	serine threonine protein kinase
BWI17_RS13900	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BWI17_RS13910	COG4181	ATPase activity
BWI17_RS13915	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BWI17_RS13935	COG5285	phytanoyl-CoA dioxygenase
BWI17_RS13970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BWI17_RS13990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWI17_RS13990	COG5322	oxidoreductase activity
BWI17_RS13995	COG0535	radical SAM domain protein
BWI17_RS14035	COG0535	radical SAM domain protein
BWI17_RS14040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWI17_RS14050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWI17_RS14060	COG0778	Nitroreductase
BWI17_RS14065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWI17_RS14080	COG0235	Class ii aldolase
BWI17_RS14100	COG0564	pseudouridine synthase activity
BWI17_RS14115	COG3243	poly(R)-hydroxyalkanoic acid synthase
BWI17_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS14130	COG2205	protein histidine kinase activity
BWI17_RS14135	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS14140	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BWI17_RS14145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWI17_RS14155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BWI17_RS14175	COG0683	leucine binding
BWI17_RS14180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BWI17_RS14195	COG1136	(ABC) transporter
BWI17_RS14260	COG2308	Evidence 4 Homologs of previously reported genes of
BWI17_RS14270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BWI17_RS14290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BWI17_RS14295	COG0456	acetyltransferase
BWI17_RS14310	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BWI17_RS14315	COG0830	nickel cation binding
BWI17_RS14320	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BWI17_RS14325	COG0804	urea catabolic process
BWI17_RS14330	COG0832	Belongs to the urease beta subunit family
BWI17_RS14335	COG0831	urea catabolic process
BWI17_RS14340	COG0829	nickel cation binding
BWI17_RS14370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BWI17_RS14375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BWI17_RS14380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWI17_RS14395	COG1414	Transcriptional regulator
BWI17_RS14400	COG3485	protocatechuate 3,4-dioxygenase
BWI17_RS14405	COG3485	protocatechuate 3,4-dioxygenase
BWI17_RS14410	COG0683	leucine binding
BWI17_RS14420	COG4177	L-phenylalanine transmembrane transporter activity
BWI17_RS14445	COG0583	DNA-binding transcription factor activity
BWI17_RS14460	COG3384	dioxygenase
BWI17_RS14465	COG2159	amidohydrolase
BWI17_RS14480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BWI17_RS14485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BWI17_RS14490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BWI17_RS14495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BWI17_RS14500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BWI17_RS14505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWI17_RS14505	COG0072	phenylalanine-tRNA ligase activity
BWI17_RS14510	COG0776	regulation of translation
BWI17_RS14540	COG0438	transferase activity, transferring glycosyl groups
BWI17_RS14750	COG0175	sulfate reduction
BWI17_RS14780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWI17_RS14785	COG0156	8-amino-7-oxononanoate synthase activity
BWI17_RS14790	COG0604	alcohol dehydrogenase
BWI17_RS14790	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS14790	COG3321	synthase
BWI17_RS14825	COG0509	glycine decarboxylation via glycine cleavage system
BWI17_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS14845	COG3590	peptidase
BWI17_RS14850	COG3590	peptidase
BWI17_RS14855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BWI17_RS14860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWI17_RS14865	COG1388	LysM domain
BWI17_RS14865	COG4942	peptidase
BWI17_RS14870	COG0653	protein targeting
BWI17_RS14885	COG0714	Associated with various cellular activities
BWI17_RS14900	COG1872	DUF167
BWI17_RS14910	COG1126	abc transporter atp-binding protein
BWI17_RS14915	COG0765	amino acid transport
BWI17_RS14920	COG0765	amino acid transport
BWI17_RS14930	COG2902	Dehydrogenase
BWI17_RS14945	COG0484	heat shock protein binding
BWI17_RS14950	COG0436	Aminotransferase
BWI17_RS14985	COG2853	Lipoprotein
BWI17_RS14995	COG0542	response to heat
BWI17_RS15005	COG1183	phosphatidylcholine synthase activity
BWI17_RS15035	COG2205	protein histidine kinase activity
BWI17_RS15130	COG3964	amidohydrolase
BWI17_RS15150	COG0640	Transcriptional regulator
BWI17_RS15155	COG2050	protein possibly involved in aromatic compounds catabolism
BWI17_RS15165	COG3181	Tripartite tricarboxylate transporter family receptor
BWI17_RS15170	COG2201	protein-glutamate methylesterase activity
BWI17_RS15215	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWI17_RS15220	COG2205	protein histidine kinase activity
BWI17_RS15245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWI17_RS15250	COG1024	Enoyl-CoA hydratase
BWI17_RS15260	COG2814	Major facilitator Superfamily
BWI17_RS15265	COG0519	Catalyzes the synthesis of GMP from XMP
BWI17_RS15270	COG2755	lipolytic protein G-D-S-L family
BWI17_RS15270	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BWI17_RS15280	COG0577	efflux transmembrane transporter activity
BWI17_RS15285	COG1136	(ABC) transporter
BWI17_RS15295	COG0516	GMP reductase activity
BWI17_RS15295	COG0517	IMP dehydrogenase activity
BWI17_RS15305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BWI17_RS15305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BWI17_RS15310	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BWI17_RS15330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWI17_RS15340	COG0481	GTPase activity
BWI17_RS15345	COG0681	Belongs to the peptidase S26 family
BWI17_RS15355	COG0571	ribonuclease III activity
BWI17_RS15360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BWI17_RS15365	COG1381	Involved in DNA repair and RecF pathway recombination
BWI17_RS15370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BWI17_RS15375	COG0736	holo-[acyl-carrier-protein] synthase activity
BWI17_RS15380	COG1472	Belongs to the glycosyl hydrolase 3 family
BWI17_RS15385	COG0322	excinuclease ABC activity
BWI17_RS15405	COG0583	DNA-binding transcription factor activity
BWI17_RS15445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BWI17_RS15525	COG3201	nicotinamide mononucleotide transporter
BWI17_RS15535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BWI17_RS15545	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BWI17_RS15550	COG0737	Belongs to the 5'-nucleotidase family
BWI17_RS15550	COG1525	nuclease
BWI17_RS15550	COG4085	toxin activity
BWI17_RS15560	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BWI17_RS15565	COG1012	belongs to the aldehyde dehydrogenase family
BWI17_RS15575	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BWI17_RS15580	COG0295	cytidine deaminase activity
BWI17_RS15585	COG1079	Belongs to the binding-protein-dependent transport system permease family
BWI17_RS15595	COG3845	ABC transporter
BWI17_RS15600	COG1609	Transcriptional regulator
BWI17_RS15605	COG1744	ABC transporter substrate-binding protein PnrA-like
BWI17_RS15610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BWI17_RS15615	COG0402	S-adenosylhomocysteine deaminase activity
BWI17_RS15670	COG3246	L-lysine catabolic process to acetate
BWI17_RS15675	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS15680	COG2264	protein methyltransferase activity
BWI17_RS15690	COG1187	pseudouridine synthase activity
BWI17_RS15695	COG0697	spore germination
BWI17_RS15720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWI17_RS15740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BWI17_RS15750	COG0288	reversible hydration of carbon dioxide
BWI17_RS15760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWI17_RS15765	COG0281	malic enzyme
BWI17_RS15770	COG0302	gtp cyclohydrolase
BWI17_RS15790	COG0436	Aminotransferase
BWI17_RS15795	COG4251	negative regulation of phosphorylation
BWI17_RS15800	COG0556	nucleotide-excision repair
BWI17_RS15805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BWI17_RS15820	COG1530	ribonuclease E activity
BWI17_RS15825	COG0564	pseudouridine synthase activity
BWI17_RS15830	COG0546	phosphoglycolate phosphatase activity
BWI17_RS15850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BWI17_RS15855	COG0424	maF-like protein
BWI17_RS15865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BWI17_RS15870	COG0416	fatty acid biosynthetic process
BWI17_RS15875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BWI17_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS15890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWI17_RS15895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWI17_RS15900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWI17_RS15905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BWI17_RS15910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BWI17_RS15925	COG0084	hydrolase, TatD family'
BWI17_RS15935	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BWI17_RS15940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWI17_RS15955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BWI17_RS15960	COG4221	oxidoreductase activity
BWI17_RS15995	COG0251	oxidation-reduction process
BWI17_RS16015	COG0318	PFAM AMP-dependent synthetase and ligase
BWI17_RS16030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWI17_RS16035	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BWI17_RS16065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BWI17_RS16075	COG0247	lactate metabolic process
BWI17_RS16075	COG0277	FAD linked oxidase domain protein
BWI17_RS16080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BWI17_RS16085	COG0318	PFAM AMP-dependent synthetase and ligase
BWI17_RS16125	COG3128	pkhd-type hydroxylase
BWI17_RS16130	COG4774	siderophore transport
BWI17_RS16145	COG0672	)-iron permease
BWI17_RS16160	COG4946	Tricorn protease homolog
BWI17_RS16160	COG1506	peptidase
BWI17_RS16160	COG0823	Involved in the tonB-independent uptake of proteins
BWI17_RS16175	COG2353	YceI-like domain
BWI17_RS16185	COG3038	cytochrome b561
BWI17_RS16190	COG0114	fumarate hydratase activity
BWI17_RS16195	COG3237	CsbD-like
BWI17_RS16200	COG2204	response regulator
BWI17_RS16205	COG2204	response regulator
BWI17_RS16220	COG1435	thymidine kinase activity
BWI17_RS16240	COG4206	TonB-dependent receptor
BWI17_RS16255	COG0587	DNA-directed DNA polymerase activity
BWI17_RS16270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BWI17_RS16275	COG0640	Transcriptional regulator
BWI17_RS16410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BWI17_RS16420	COG0314	molybdopterin synthase activity
BWI17_RS16425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BWI17_RS16430	COG1763	Mo-molybdopterin cofactor biosynthetic process
BWI17_RS16435	COG1609	Transcriptional regulator
BWI17_RS16440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWI17_RS16450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWI17_RS16460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWI17_RS16460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWI17_RS16470	COG4677	pectinesterase activity
BWI17_RS16485	COG0473	3-isopropylmalate dehydrogenase activity
BWI17_RS16505	COG3243	poly(R)-hydroxyalkanoic acid synthase
BWI17_RS16530	COG1322	Protein conserved in bacteria
BWI17_RS16535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWI17_RS16540	COG1217	gtp-binding protein TYPA
BWI17_RS16545	COG2346	COG2346, Truncated hemoglobins
BWI17_RS16555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BWI17_RS16570	COG0726	polysaccharide deacetylase
BWI17_RS16580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BWI17_RS16585	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BWI17_RS16590	COG1858	cytochrome C peroxidase
BWI17_RS16620	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BWI17_RS16630	COG1013	pyruvate-flavodoxin oxidoreductase activity
BWI17_RS16635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BWI17_RS16635	COG0674	pyruvate-flavodoxin oxidoreductase activity
BWI17_RS16645	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BWI17_RS16655	COG0840	transmembrane signaling receptor activity
BWI17_RS16660	COG0835	chemotaxis
BWI17_RS16665	COG0840	transmembrane signaling receptor activity
BWI17_RS16670	COG0840	transmembrane signaling receptor activity
BWI17_RS16675	COG2198	Histidine kinase
BWI17_RS16675	COG0643	Histidine kinase
BWI17_RS16735	COG0492	ferredoxin-NADP+ reductase activity
BWI17_RS16775	COG4133	protoheme IX ABC transporter activity
BWI17_RS16785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWI17_RS16795	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BWI17_RS16805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWI17_RS16810	COG3088	subunit of a heme lyase
BWI17_RS16815	COG1414	Transcriptional regulator
BWI17_RS16835	COG1573	uracil-dna glycosylase
BWI17_RS16840	COG0456	acetyltransferase
BWI17_RS16845	COG1214	PFAM Peptidase M22, glycoprotease
BWI17_RS16900	COG1199	ATP-dependent helicase activity
BWI17_RS16910	COG4555	ABC transporter
BWI17_RS16930	COG0412	Dienelactone hydrolase
BWI17_RS16950	COG1840	ABC-type Fe3 transport system, periplasmic component
BWI17_RS16955	COG3842	ATPase activity
BWI17_RS17005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWI17_RS17035	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS17055	COG0183	Belongs to the thiolase family
BWI17_RS17070	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS17085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BWI17_RS17090	COG1024	Enoyl-CoA hydratase
BWI17_RS17120	COG4770	biotin carboxylase activity
BWI17_RS17130	COG2205	protein histidine kinase activity
BWI17_RS17135	COG0745	RESPONSE REGULATOR receiver
BWI17_RS17140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWI17_RS17165	COG4191	Histidine kinase
BWI17_RS17170	COG4566	intracellular signal transduction
BWI17_RS17190	COG2985	domain, Protein
BWI17_RS17210	COG2755	lipolytic protein G-D-S-L family
BWI17_RS17210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BWI17_RS17220	COG1024	Enoyl-CoA hydratase
BWI17_RS17225	COG1024	Enoyl-CoA hydratase
BWI17_RS17230	COG0179	Fumarylacetoacetate (FAA) hydrolase
BWI17_RS17280	COG3064	Membrane
BWI17_RS17285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWI17_RS17305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BWI17_RS17330	COG1960	acyl-CoA dehydrogenase activity
BWI17_RS17350	COG1136	(ABC) transporter
BWI17_RS17350	COG0577	efflux transmembrane transporter activity
BWI17_RS17355	COG1136	(ABC) transporter
BWI17_RS17370	COG3655	Transcriptional regulator
BWI17_RS17375	COG1309	transcriptional regulator
BWI17_RS17380	COG0625	glutathione transferase activity
BWI17_RS17405	COG0559	Belongs to the binding-protein-dependent transport system permease family
BWI17_RS17415	COG0410	ABC transporter
BWI17_RS17440	COG1024	Enoyl-CoA hydratase
BWI17_RS17455	COG0318	PFAM AMP-dependent synthetase and ligase
BWI17_RS17460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BWI17_RS17475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWI17_RS17485	COG0604	alcohol dehydrogenase
BWI17_RS17490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BWI17_RS17500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWI17_RS17515	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWI17_RS17520	COG0567	Dehydrogenase, E1 component
BWI17_RS17525	COG0372	Belongs to the citrate synthase family
BWI17_RS17530	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BWI17_RS17535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BWI17_RS17540	COG1053	succinate dehydrogenase
BWI17_RS17545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BWI17_RS17565	COG2030	dehydratase
BWI17_RS17590	COG2079	MmgE PrpD family protein
BWI17_RS17600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BWI17_RS17630	COG1802	Transcriptional regulator
BWI17_RS17650	COG0306	phosphate transporter
BWI17_RS17655	COG1392	Phosphate transport regulator
BWI17_RS17695	COG0697	spore germination
BWI17_RS17700	COG5001	Diguanylate cyclase
BWI17_RS17700	COG3300	MHYT domain
BWI17_RS17740	COG4251	negative regulation of phosphorylation
BWI17_RS17755	COG4251	negative regulation of phosphorylation
BWI17_RS17765	COG2201	protein-glutamate methylesterase activity
BWI17_RS17770	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BWI17_RS17790	COG0840	transmembrane signaling receptor activity
BWI17_RS17800	COG0840	transmembrane signaling receptor activity
BWI17_RS17805	COG0643	Histidine kinase
BWI17_RS17805	COG2198	Histidine kinase
BWI17_RS17820	COG3851	Histidine kinase
BWI17_RS17835	COG1256	bacterial-type flagellum assembly
BWI17_RS17840	COG1705	Flagellar rod assembly protein muramidase FlgJ
BWI17_RS17840	COG3951	Flagellar rod assembly protein muramidase FlgJ
BWI17_RS17845	COG1706	bacterial-type flagellum-dependent cell motility
BWI17_RS17850	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BWI17_RS17860	COG4787	bacterial-type flagellum-dependent cell motility
BWI17_RS17865	COG1749	Flagellar hook protein flgE
BWI17_RS17875	COG1558	bacterial-type flagellum-dependent cell motility
BWI17_RS17900	COG0745	RESPONSE REGULATOR receiver
BWI17_RS17905	COG4191	Histidine kinase
BWI17_RS17925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BWI17_RS17950	COG2198	Histidine kinase
BWI17_RS17950	COG0784	Response regulator, receiver
BWI17_RS17950	COG0643	Histidine kinase
BWI17_RS17955	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BWI17_RS17965	COG0835	chemotaxis
BWI17_RS17970	COG1360	Flagellar Motor Protein
BWI17_RS17995	COG1334	flagellar protein FlaG
BWI17_RS18000	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BWI17_RS18025	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BWI17_RS18030	COG1677	Flagellar hook-basal body complex protein FliE
BWI17_RS18050	COG1157	protein secretion by the type III secretion system
BWI17_RS18075	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BWI17_RS18080	COG3190	flagellar
BWI17_RS18090	COG1987	bacterial-type flagellum assembly
BWI17_RS18100	COG5001	Diguanylate cyclase
BWI17_RS18155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BWI17_RS18165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWI17_RS18175	COG0745	RESPONSE REGULATOR receiver
BWI17_RS18185	COG5001	Diguanylate cyclase
BWI17_RS18185	COG4251	negative regulation of phosphorylation
BWI17_RS18185	COG2203	Gaf domain
BWI17_RS18185	COG3706	GGDEF domain
BWI17_RS18200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWI17_RS18305	COG2165	general secretion pathway protein
BWI17_RS18325	COG0840	transmembrane signaling receptor activity
BWI17_RS18330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BWI17_RS18405	COG0187	DNA topoisomerase II activity
BWI17_RS18415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BWI17_RS18420	COG0517	IMP dehydrogenase activity
BWI17_RS18450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWI17_RS18455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BWI17_RS18460	COG0741	lytic transglycosylase activity
BWI17_RS18480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWI17_RS18495	COG0154	amidase activity
BWI17_RS18500	COG4968	Prepilin-type N-terminal cleavage methylation domain
BWI17_RS18505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWI17_RS18510	COG2721	sulfolactate sulfo-lyase activity
BWI17_RS18515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWI17_RS18530	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS18535	COG0179	Fumarylacetoacetate (FAA) hydrolase
BWI17_RS18540	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BWI17_RS18545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWI17_RS18580	COG0840	transmembrane signaling receptor activity
BWI17_RS18605	COG3833	ABC-type maltose transport systems, permease component
BWI17_RS18610	COG1175	transmembrane transport
BWI17_RS18620	COG3842	ATPase activity
BWI17_RS18625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWI17_RS18630	COG0129	dihydroxy-acid dehydratase activity
BWI17_RS18635	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS18650	COG5002	protein histidine kinase activity
BWI17_RS18650	COG2205	protein histidine kinase activity
BWI17_RS18650	COG0784	Response regulator, receiver
BWI17_RS18665	COG2986	histidine ammonia-lyase
BWI17_RS18675	COG0135	phosphoribosylanthranilate isomerase activity
BWI17_RS18680	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BWI17_RS18685	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BWI17_RS18735	COG0681	Belongs to the peptidase S26 family
BWI17_RS18765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BWI17_RS18780	COG2264	protein methyltransferase activity
BWI17_RS18805	COG1592	Rubrerythrin
BWI17_RS18810	COG0247	lactate metabolic process
BWI17_RS18825	COG0583	DNA-binding transcription factor activity
BWI17_RS18830	COG0678	peroxiredoxin activity
BWI17_RS18830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BWI17_RS18855	COG0584	glycerophosphoryl diester phosphodiesterase
BWI17_RS18860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BWI17_RS18865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BWI17_RS18870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWI17_RS18875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BWI17_RS18895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWI17_RS18895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWI17_RS18900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BWI17_RS18905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BWI17_RS18930	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWI17_RS18940	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BWI17_RS18945	COG0312	modulator of DNA gyrase
BWI17_RS18950	COG3028	Belongs to the UPF0307 family
BWI17_RS18955	COG0521	Mo-molybdopterin cofactor biosynthetic process
BWI17_RS18975	COG0497	DNA recombination
BWI17_RS18980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BWI17_RS18985	COG1420	regulation of RNA biosynthetic process
BWI17_RS18990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BWI17_RS19000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BWI17_RS19005	COG0443	Heat shock 70 kDa protein
BWI17_RS19010	COG0484	heat shock protein binding
BWI17_RS19020	COG0215	cysteine-tRNA ligase activity
BWI17_RS19045	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWI17_RS19060	COG1834	amidinotransferase
BWI17_RS19080	COG0285	dihydrofolate synthase activity
BWI17_RS19085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BWI17_RS19090	COG0159	tryptophan synthase activity
BWI17_RS19095	COG0133	tryptophan synthase activity
BWI17_RS19100	COG0135	phosphoribosylanthranilate isomerase activity
BWI17_RS19105	COG0101	tRNA pseudouridine synthase activity
BWI17_RS19120	COG0473	3-isopropylmalate dehydrogenase activity
BWI17_RS19125	COG0066	3-isopropylmalate dehydratase activity
BWI17_RS19135	COG2814	Major facilitator Superfamily
BWI17_RS19140	COG1566	PFAM secretion protein HlyD family protein
BWI17_RS19150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWI17_RS19155	COG3590	peptidase
BWI17_RS19175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BWI17_RS19195	COG0640	Transcriptional regulator
BWI17_RS19230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BWI17_RS19235	COG1111	helicase
BWI17_RS19235	COG1205	dead DEAH box helicase
BWI17_RS19240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BWI17_RS19270	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BWI17_RS19320	COG0477	Major facilitator Superfamily
BWI17_RS19345	COG1619	proteins homologs of microcin C7 resistance protein MccF
BWI17_RS19350	COG0625	glutathione transferase activity
BWI17_RS19370	COG0427	acetyl-CoA hydrolase
BWI17_RS19375	COG2988	succinylglutamate desuccinylase activity
BWI17_RS19380	COG0700	Nucleoside recognition
BWI17_RS19390	COG3023	N-Acetylmuramoyl-L-alanine amidase
BWI17_RS19400	COG1619	proteins homologs of microcin C7 resistance protein MccF
BWI17_RS19425	COG3791	Glutathione-dependent formaldehyde-activating
BWI17_RS19430	COG3119	arylsulfatase activity
BWI17_RS19465	COG3338	carbonate dehydratase activity
BWI17_RS19475	COG1301	dicarboxylic acid transport
BWI17_RS19505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BWI17_RS19510	COG3265	gluconokinase activity
BWI17_RS19555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BWI17_RS19560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BWI17_RS19575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BWI17_RS19585	COG0709	Synthesizes selenophosphate from selenide and ATP
BWI17_RS19590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BWI17_RS19595	COG0596	Alpha beta hydrolase
BWI17_RS19595	COG2226	methyltransferase
BWI17_RS19595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWI17_RS19600	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BWI17_RS19605	COG0543	2 iron, 2 sulfur cluster binding
BWI17_RS19605	COG0493	'glutamate synthase
BWI17_RS19645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BWI17_RS19660	COG0525	valine-tRNA ligase activity
BWI17_RS19680	COG0425	Belongs to the sulfur carrier protein TusA family
BWI17_RS19695	COG0315	cyclic pyranopterin monophosphate synthase activity
BWI17_RS19710	COG3258	Cytochrome c
BWI17_RS19735	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BWI17_RS19740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BWI17_RS19745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BWI17_RS19760	COG0631	protein serine/threonine phosphatase activity
BWI17_RS19765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BWI17_RS19770	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWI17_RS19775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWI17_RS19785	COG2816	NAD+ diphosphatase activity
BWI17_RS19790	COG0438	transferase activity, transferring glycosyl groups
BWI17_RS19810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BWI17_RS19820	COG2137	regulation of response to DNA damage stimulus
BWI17_RS19825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BWI17_RS19830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BWI17_RS19835	COG1546	Belongs to the CinA family
BWI17_RS19845	COG3842	ATPase activity
BWI17_RS19850	COG0395	ABC-type sugar transport system, permease component
BWI17_RS19860	COG1653	transport
BWI17_RS19870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BWI17_RS19875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BWI17_RS19880	COG0501	Belongs to the peptidase M48B family
BWI17_RS19885	COG2154	pterin-4-alpha-carbinolamine dehydratase
BWI17_RS19890	COG1162	GTPase activity
BWI17_RS19895	COG1301	dicarboxylic acid transport
BWI17_RS19965	COG0019	diaminopimelate decarboxylase activity
BWI17_RS19970	COG0717	Belongs to the dCTP deaminase family
BWI17_RS19975	COG0489	protein tyrosine kinase activity
BWI17_RS19980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWI17_RS19980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWI17_RS19990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BWI17_RS19995	COG1254	Belongs to the acylphosphatase family
BWI17_RS20010	COG1393	Belongs to the ArsC family
BWI17_RS20040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWI17_RS20040	COG0519	Catalyzes the synthesis of GMP from XMP
BWI17_RS20070	COG2914	Belongs to the UPF0125 (RnfH) family
BWI17_RS20075	COG2867	negative regulation of translational initiation
BWI17_RS20080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BWI17_RS20105	COG1185	polyribonucleotide nucleotidyltransferase activity
BWI17_RS20110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BWI17_RS20115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BWI17_RS20120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BWI17_RS20125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BWI17_RS20130	COG0195	Participates in both transcription termination and antitermination
BWI17_RS20130	COG2251	uridine kinase activity
BWI17_RS20135	COG0779	Required for maturation of 30S ribosomal subunits
BWI17_RS20140	COG4206	TonB-dependent receptor
BWI17_RS20150	COG2205	protein histidine kinase activity
BWI17_RS20160	COG1247	-acetyltransferase
BWI17_RS20165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BWI17_RS20190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BWI17_RS20205	COG0823	Involved in the tonB-independent uptake of proteins
BWI17_RS20225	COG0824	Thioesterase
BWI17_RS20230	COG2255	four-way junction helicase activity
BWI17_RS20235	COG0632	four-way junction helicase activity
BWI17_RS20240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BWI17_RS20250	COG0217	transcriptional regulatory protein
BWI17_RS20255	COG0433	COG0433 Predicted ATPase
BWI17_RS20270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BWI17_RS20275	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWI17_RS20285	COG0542	response to heat
BWI17_RS20290	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BWI17_RS20295	COG1278	Cold shock
BWI17_RS20300	COG0538	isocitrate dehydrogenase activity
BWI17_RS20315	COG0482	sulfurtransferase activity
BWI17_RS20320	COG0625	glutathione transferase activity
BWI17_RS20335	COG0656	L-ascorbic acid biosynthetic process
BWI17_RS20345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWI17_RS20355	COG1183	phosphatidylcholine synthase activity
BWI17_RS20365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BWI17_RS20375	COG0028	Belongs to the TPP enzyme family
BWI17_RS20410	COG4566	intracellular signal transduction
BWI17_RS20415	COG0745	RESPONSE REGULATOR receiver
BWI17_RS20420	COG5002	protein histidine kinase activity
BWI17_RS20430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWI17_RS20445	COG4948	Mandelate Racemase Muconate Lactonizing
BWI17_RS20450	COG1175	transmembrane transport
BWI17_RS20455	COG0395	ABC-type sugar transport system, permease component
BWI17_RS20460	COG3842	ATPase activity
BWI17_RS20470	COG0823	Involved in the tonB-independent uptake of proteins
BWI17_RS20475	COG3866	Pectate lyase
BWI17_RS20490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BWI17_RS20495	COG0560	Phosphoserine phosphatase
BWI17_RS20505	COG2205	protein histidine kinase activity
BWI17_RS20515	COG2204	response regulator
BWI17_RS20530	COG4772	TonB-dependent receptor
BWI17_RS20560	COG0443	Heat shock 70 kDa protein
BWI17_RS20570	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BWI17_RS20580	COG0822	iron-sulfur transferase activity
BWI17_RS20585	COG1104	cysteine desulfurase activity
BWI17_RS20610	COG0483	inositol monophosphate 1-phosphatase activity
BWI17_RS20615	COG1252	NADH dehydrogenase
BWI17_RS20620	COG1652	LysM domain
BWI17_RS20635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BWI17_RS20650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BWI17_RS20655	COG2850	peptidyl-arginine hydroxylation
BWI17_RS20670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWI17_RS20675	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BWI17_RS20680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWI17_RS20695	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BWI17_RS20710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BWI17_RS20720	COG3842	ATPase activity
BWI17_RS20725	COG1840	ABC-type Fe3 transport system, periplasmic component
BWI17_RS20740	COG1012	belongs to the aldehyde dehydrogenase family
BWI17_RS20745	COG1283	sodium-dependent phosphate transmembrane transporter activity
BWI17_RS20755	COG1280	lysine exporter protein (LysE YggA)
BWI17_RS20775	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BWI17_RS20810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BWI17_RS20815	COG1012	belongs to the aldehyde dehydrogenase family
BWI17_RS20860	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BWI17_RS20915	COG2084	Dehydrogenase
BWI17_RS20925	COG0559	Belongs to the binding-protein-dependent transport system permease family
BWI17_RS20930	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS20935	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS20945	COG1612	heme a metabolic process
BWI17_RS20970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BWI17_RS20980	COG2267	carboxylic ester hydrolase activity
BWI17_RS20985	COG2020	methyltransferase activity
BWI17_RS21015	COG1022	Amp-dependent synthetase and ligase
BWI17_RS21020	COG1024	Enoyl-CoA hydratase
BWI17_RS21030	COG0183	Belongs to the thiolase family
BWI17_RS21035	COG0683	leucine binding
BWI17_RS21055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWI17_RS21055	COG2205	protein histidine kinase activity
BWI17_RS21060	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BWI17_RS21075	COG1505	serine-type exopeptidase activity
BWI17_RS21085	COG5001	Diguanylate cyclase
BWI17_RS21095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWI17_RS21100	COG2186	Transcriptional regulator
BWI17_RS21105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWI17_RS21140	COG0670	Belongs to the BI1 family
BWI17_RS21145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BWI17_RS21185	COG1201	RNA secondary structure unwinding
BWI17_RS21190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWI17_RS21220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BWI17_RS21235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWI17_RS21235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWI17_RS21250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BWI17_RS21410	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BWI17_RS21420	COG1266	CAAX protease self-immunity
BWI17_RS21445	COG0789	Transcriptional regulator
BWI17_RS21530	COG4608	Belongs to the ABC transporter superfamily
BWI17_RS21535	COG0444	Belongs to the ABC transporter superfamily
BWI17_RS21540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWI17_RS21545	COG0601	transmembrane transport
BWI17_RS21555	COG0747	negative chemotaxis
BWI17_RS21600	COG1297	OPT oligopeptide transporter protein
BWI17_RS21605	COG0840	transmembrane signaling receptor activity
BWI17_RS21620	COG3062	negative regulation of establishment of protein localization
BWI17_RS21625	COG0243	molybdopterin cofactor binding
BWI17_RS21630	COG3043	anaerobic respiration
BWI17_RS21635	COG3005	denitrification pathway
BWI17_RS21650	COG2151	metal-sulfur cluster biosynthetic enzyme
BWI17_RS21660	COG1272	protein, Hemolysin III
BWI17_RS21690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWI17_RS21700	COG2070	2-Nitropropane dioxygenase
BWI17_RS21725	COG3945	hemerythrin HHE cation binding domain
BWI17_RS21745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BWI17_RS21770	COG2197	response regulator
BWI17_RS21775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWI17_RS21785	COG0045	succinate-CoA ligase (ADP-forming) activity
BWI17_RS21785	COG1042	CoA-binding domain protein
BWI17_RS21785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BWI17_RS21805	COG0348	domain, Protein
BWI17_RS21825	COG3278	Belongs to the heme-copper respiratory oxidase family
BWI17_RS21830	COG3706	GGDEF domain
BWI17_RS21850	COG2391	methyltransferase activity
BWI17_RS21855	COG2226	methyltransferase
BWI17_RS21860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BWI17_RS21875	COG3245	cytochrome
BWI17_RS21905	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BWI17_RS21920	COG0515	serine threonine protein kinase
BWI17_RS21920	COG2815	serine threonine protein kinase
BWI17_RS21930	COG0515	serine threonine protein kinase
BWI17_RS21930	COG2815	serine threonine protein kinase
BWI17_RS21950	COG0515	serine threonine protein kinase
BWI17_RS21950	COG2815	serine threonine protein kinase
BWI17_RS21960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWI17_RS21970	COG1028	Short-chain dehydrogenase reductase Sdr
BWI17_RS21975	COG2153	protein acetylation
BWI17_RS21990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BWI17_RS22010	COG1752	Esterase of the alpha-beta hydrolase superfamily
BWI17_RS22025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BWI17_RS22030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWI17_RS22035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWI17_RS22040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWI17_RS22045	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWI17_RS22055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWI17_RS22065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BWI17_RS22070	COG0575	Belongs to the CDS family
BWI17_RS22075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BWI17_RS22080	COG0233	cytoplasmic translational termination
BWI17_RS22085	COG0528	UMP kinase activity
BWI17_RS22090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BWI17_RS22095	COG0052	Belongs to the universal ribosomal protein uS2 family
BWI17_RS22100	COG0024	Methionine aminopeptidase
BWI17_RS22105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BWI17_RS22130	COG0242	peptide deformylase activity
BWI17_RS22140	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BWI17_RS22140	COG0037	tRNA processing
BWI17_RS22145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BWI17_RS22150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWI17_RS22165	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BWI17_RS22185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWI17_RS22205	COG2171	N-acyltransferase activity
BWI17_RS22230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWI17_RS22260	COG0259	pyridoxamine-phosphate oxidase activity
BWI17_RS22270	COG2084	Dehydrogenase
BWI17_RS22290	COG1335	isochorismatase
BWI17_RS22305	COG0583	DNA-binding transcription factor activity
BWI17_RS22315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BWI17_RS22320	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BWI17_RS22330	COG0180	Tryptophanyl-tRNA synthetase
BWI17_RS22335	COG1994	Peptidase M50
BWI17_RS22340	COG0009	L-threonylcarbamoyladenylate synthase
BWI17_RS22345	COG0613	PHP domain protein
BWI17_RS22355	COG2917	probably involved in intracellular septation
BWI17_RS22360	COG2350	Protein conserved in bacteria
BWI17_RS22370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWI17_RS22395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BWI17_RS22400	COG0840	transmembrane signaling receptor activity
BWI17_RS22410	COG0047	phosphoribosylformylglycinamidine synthase activity
BWI17_RS22410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BWI17_RS22430	COG0697	spore germination
BWI17_RS22440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BWI17_RS22455	COG0583	DNA-binding transcription factor activity
BWI17_RS22470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BWI17_RS22490	COG0443	Heat shock 70 kDa protein
BWI17_RS22510	COG2274	protein secretion by the type I secretion system
BWI17_RS22515	COG2274	protein secretion by the type I secretion system
BWI17_RS22525	COG3707	response regulator
BWI17_RS22530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWI17_RS22535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component