locus-tag	class	description
F542_RS00010	COG0799	negative regulation of ribosome biogenesis
F542_RS00015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F542_RS00020	COG0768	penicillin binding
F542_RS00025	COG0772	Belongs to the SEDS family
F542_RS00035	COG1686	Belongs to the peptidase S11 family
F542_RS00055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F542_RS00060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F542_RS00060	COG1263	PTS System
F542_RS00060	COG2190	(PTS) system
F542_RS00070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F542_RS00075	COG3962	Belongs to the TPP enzyme family
F542_RS00085	COG0673	inositol 2-dehydrogenase activity
F542_RS00095	COG0673	inositol 2-dehydrogenase activity
F542_RS00100	COG1172	Belongs to the binding-protein-dependent transport system permease family
F542_RS00105	COG1129	ABC transporter
F542_RS00120	COG3718	enzyme involved in inositol metabolism
F542_RS00130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F542_RS00135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F542_RS00140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F542_RS00150	COG1414	Transcriptional regulator
F542_RS00175	COG1194	a g-specific adenine glycosylase
F542_RS00180	COG0346	lactoylglutathione lyase activity
F542_RS00190	COG3477	response to acidic pH
F542_RS00195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F542_RS00200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F542_RS00205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F542_RS00220	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
F542_RS00230	COG0019	diaminopimelate decarboxylase activity
F542_RS00235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F542_RS00250	COG0081	regulation of translation
F542_RS00255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F542_RS00265	COG0085	RNA polymerase activity
F542_RS00285	COG2814	Major facilitator Superfamily
F542_RS00300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F542_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
F542_RS00315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F542_RS00340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F542_RS00420	COG0642	Histidine kinase
F542_RS00425	COG0745	RESPONSE REGULATOR receiver
F542_RS00445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F542_RS00460	COG1609	Transcriptional regulator
F542_RS00470	COG0259	pyridoxamine-phosphate oxidase activity
F542_RS00480	COG0758	DNA mediated transformation
F542_RS00515	COG4974	Belongs to the 'phage' integrase family
F542_RS00520	COG0431	NADPH-dependent FMN reductase
F542_RS00550	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F542_RS00560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F542_RS00580	COG3177	Filamentation induced by cAMP protein fic
F542_RS00595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F542_RS00615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F542_RS00620	COG0730	response to heat
F542_RS00635	COG0204	Acyl-transferase
F542_RS00660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F542_RS00665	COG1022	Amp-dependent synthetase and ligase
F542_RS00670	COG0765	amino acid transport
F542_RS00675	COG1126	abc transporter atp-binding protein
F542_RS00685	COG1970	mechanosensitive ion channel activity
F542_RS00690	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
F542_RS00695	COG2226	methyltransferase
F542_RS00725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F542_RS00730	COG0805	protein transport
F542_RS00755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F542_RS00760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F542_RS00770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F542_RS00775	COG0051	transcription antitermination factor activity, RNA binding
F542_RS00785	COG0088	Forms part of the polypeptide exit tunnel
F542_RS00790	COG0089	rRNA binding
F542_RS00800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F542_RS00805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F542_RS00810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F542_RS00820	COG0255	Belongs to the universal ribosomal protein uL29 family
F542_RS00830	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F542_RS00835	COG0592	DNA-directed DNA polymerase activity
F542_RS00845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F542_RS00855	COG0545	Peptidyl-prolyl cis-trans isomerase
F542_RS00890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F542_RS00905	COG0598	Magnesium transport protein CorA
F542_RS00920	COG0859	PFAM glycosyl transferase family 9
F542_RS00930	COG3266	domain, Protein
F542_RS00930	COG3061	Opacity-associated protein A
F542_RS00935	COG1555	photosystem II stabilization
F542_RS00945	COG0494	nUDIX hydrolase
F542_RS00960	COG2818	Glycosylase
F542_RS00970	COG1388	LysM domain
F542_RS00970	COG4942	peptidase
F542_RS00980	COG1238	metal cluster binding
F542_RS00985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F542_RS00995	COG0149	triose-phosphate isomerase activity
F542_RS01020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F542_RS01025	COG1393	Belongs to the ArsC family
F542_RS01030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F542_RS01055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F542_RS01060	COG3172	ATPase kinase involved in NAD metabolism
F542_RS01065	COG2129	metallophosphoesterase
F542_RS01075	COG1289	transmembrane transporter activity
F542_RS01085	COG3133	Outer membrane lipoprotein
F542_RS01090	COG3102	Protein conserved in bacteria
F542_RS01095	COG0018	arginyl-trna synthetase
F542_RS01115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F542_RS01125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F542_RS01135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F542_RS01145	COG0200	Binds to the 23S rRNA
F542_RS01150	COG0201	protein transport
F542_RS01160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F542_RS01175	COG0202	RNA polymerase activity
F542_RS01185	COG0228	four-way junction DNA binding
F542_RS01205	COG1476	TRANSCRIPTIONal
F542_RS01220	COG0252	asparaginase activity
F542_RS01245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F542_RS01250	COG2003	Belongs to the UPF0758 family
F542_RS01260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F542_RS01275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F542_RS01285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F542_RS01290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F542_RS01295	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
F542_RS01300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F542_RS01305	COG0546	phosphoglycolate phosphatase activity
F542_RS01320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F542_RS01330	COG0742	ribosomal rna small subunit methyltransferase
F542_RS01335	COG0552	protein localization to endoplasmic reticulum
F542_RS01340	COG2884	Cell division ATP-binding protein ftsE
F542_RS01345	COG2177	Part of the ABC transporter FtsEX involved in
F542_RS01350	COG4774	siderophore transport
F542_RS01355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F542_RS01365	COG1120	ATPase activity
F542_RS01375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F542_RS01380	COG1584	GPR1 FUN34 yaaH family protein
F542_RS01385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F542_RS01385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F542_RS01390	COG3715	PTS system
F542_RS01395	COG3716	PTS system mannose fructose sorbose family IID component
F542_RS01400	COG4811	Protein of unknown function (DUF986)
F542_RS01420	COG1840	ABC-type Fe3 transport system, periplasmic component
F542_RS01425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F542_RS01435	COG1349	DNA-binding transcription factor activity
F542_RS01440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F542_RS01445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F542_RS01455	COG3012	SEC-C Motif Domain Protein
F542_RS01475	COG3681	Belongs to the UPF0597 family
F542_RS01480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F542_RS01485	COG2190	(PTS) system
F542_RS01490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F542_RS01495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F542_RS01500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F542_RS01505	COG3593	DNA synthesis involved in DNA repair
F542_RS01510	COG1611	Belongs to the LOG family
F542_RS01535	COG0564	pseudouridine synthase activity
F542_RS01540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F542_RS01545	COG1621	beta-fructofuranosidase activity
F542_RS01555	COG0733	neurotransmitter:sodium symporter activity
F542_RS01610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F542_RS01620	COG3590	peptidase
F542_RS01625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F542_RS01635	COG0628	permease
F542_RS01650	COG4771	TonB-dependent receptor
F542_RS01655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F542_RS01660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F542_RS01665	COG3171	Protein conserved in bacteria
F542_RS01670	COG0762	integral membrane protein
F542_RS01680	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F542_RS01690	COG4145	pantothenate transmembrane transporter activity
F542_RS01705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F542_RS01720	COG0583	DNA-binding transcription factor activity
F542_RS01725	COG3266	domain, Protein
F542_RS01730	COG0697	spore germination
F542_RS01750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F542_RS01760	COG1720	tRNA m6t6A37 methyltransferase activity
F542_RS01765	COG1575	Belongs to the MenA family. Type 1 subfamily
F542_RS01775	COG2723	6-phospho-beta-galactosidase activity
F542_RS01795	COG0564	pseudouridine synthase activity
F542_RS01800	COG0534	Mate efflux family protein
F542_RS01810	COG1132	(ABC) transporter
F542_RS01820	COG3008	intermembrane lipid transfer
F542_RS01825	COG0735	belongs to the Fur family
F542_RS01830	COG0716	FMN binding
F542_RS01840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F542_RS01845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F542_RS01850	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F542_RS01855	COG2252	PERMEase
F542_RS01860	COG3099	Belongs to the UPF0263 family
F542_RS01880	COG2995	paraquat-inducible protein a
F542_RS01890	COG0354	folic acid binding
F542_RS01895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F542_RS01910	COG0560	Phosphoserine phosphatase
F542_RS01935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F542_RS01940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F542_RS01945	COG1187	pseudouridine synthase activity
F542_RS01950	COG0009	L-threonylcarbamoyladenylate synthase
F542_RS01955	COG0640	Transcriptional regulator
F542_RS01965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F542_RS01975	COG0446	pyridine nucleotide-disulphide oxidoreductase
F542_RS02000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F542_RS02000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F542_RS02015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F542_RS02025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F542_RS02040	COG1322	Protein conserved in bacteria
F542_RS02045	COG0512	Glutamine amidotransferase of anthranilate synthase
F542_RS02060	COG2166	iron-sulfur cluster assembly
F542_RS02070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F542_RS02075	COG1663	tetraacyldisaccharide 4'-kinase activity
F542_RS02080	COG2835	tetraacyldisaccharide 4'-kinase activity
F542_RS02085	COG0084	hydrolase, TatD family'
F542_RS02090	COG1040	competence protein
F542_RS02095	COG0561	phosphatase activity
F542_RS02100	COG4783	chaperone-mediated protein folding
F542_RS02105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F542_RS02105	COG1263	PTS System
F542_RS02110	COG0366	Alpha amylase catalytic
F542_RS02120	COG1119	ATPase activity
F542_RS02125	COG1280	lysine exporter protein (LysE YggA)
F542_RS02130	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F542_RS02135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F542_RS02140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F542_RS02145	COG4796	Type ii and iii secretion system protein
F542_RS02170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F542_RS02175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F542_RS02180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F542_RS02185	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F542_RS02195	COG2431	L-lysine efflux transmembrane transporter activity
F542_RS02250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F542_RS02255	COG1966	Carbon starvation protein
F542_RS02260	COG2801	Transposase and inactivated derivatives
F542_RS02265	COG0516	GMP reductase activity
F542_RS02275	COG2960	long-chain fatty acid transporting porin activity
F542_RS02305	COG0009	L-threonylcarbamoyladenylate synthase
F542_RS02310	COG0551	DNA topoisomerase type I activity
F542_RS02320	COG2137	regulation of response to DNA damage stimulus
F542_RS02330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F542_RS02340	COG4143	(ABC) transporter
F542_RS02345	COG1702	phosphate starvation-inducible protein PhoH
F542_RS02350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F542_RS02355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F542_RS02355	COG0517	IMP dehydrogenase activity
F542_RS02375	COG1335	isochorismatase
F542_RS02395	COG3088	subunit of a heme lyase
F542_RS02395	COG4235	cytochrome complex assembly
F542_RS02400	COG4235	cytochrome complex assembly
F542_RS02400	COG3088	subunit of a heme lyase
F542_RS02405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F542_RS02415	COG1138	Cytochrome C-type biogenesis protein
F542_RS02420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F542_RS02420	COG0475	glutathione-regulated potassium exporter activity
F542_RS02430	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F542_RS02435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F542_RS02440	COG0247	lactate metabolic process
F542_RS02450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F542_RS02455	COG0584	glycerophosphoryl diester phosphodiesterase
F542_RS02460	COG2271	Major facilitator Superfamily
F542_RS02465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F542_RS02475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F542_RS02480	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
F542_RS02480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F542_RS02490	COG0243	molybdopterin cofactor binding
F542_RS02495	COG0437	4 iron, 4 sulfur cluster binding
F542_RS02500	COG0348	domain, Protein
F542_RS02505	COG3043	anaerobic respiration
F542_RS02510	COG3005	denitrification pathway
F542_RS02515	COG2990	Protein conserved in bacteria
F542_RS02525	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F542_RS02530	COG0024	Methionine aminopeptidase
F542_RS02535	COG0783	Belongs to the Dps family
F542_RS02550	COG0792	nuclease activity
F542_RS02555	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F542_RS02565	COG1127	ABC transporter
F542_RS02570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F542_RS02575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F542_RS02580	COG2854	intermembrane phospholipid transfer
F542_RS02590	COG5007	Belongs to the BolA IbaG family
F542_RS02605	COG1138	Cytochrome C-type biogenesis protein
F542_RS02615	COG1640	4-alpha-glucanotransferase
F542_RS02625	COG0187	DNA topoisomerase II activity
F542_RS02655	COG0488	(ABC) transporter
F542_RS02665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F542_RS02675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F542_RS02680	COG1129	ABC transporter
F542_RS02680	COG0842	Transport permease protein
F542_RS02685	COG0842	Transport permease protein
F542_RS02690	COG1538	Outer membrane efflux protein
F542_RS02695	COG0402	S-adenosylhomocysteine deaminase activity
F542_RS02700	COG3023	N-Acetylmuramoyl-L-alanine amidase
F542_RS02705	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F542_RS02710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F542_RS02715	COG0705	Rhomboid family
F542_RS02720	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F542_RS02745	COG3550	peptidyl-serine autophosphorylation
F542_RS02780	COG1410	methionine synthase
F542_RS02780	COG0646	methionine synthase
F542_RS02785	COG0676	glucose-6-phosphate 1-epimerase activity
F542_RS02795	COG3068	Protein conserved in bacteria
F542_RS02825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F542_RS02855	COG4591	ABC-type transport system involved in lipoprotein release permease component
F542_RS02865	COG3381	protein complex oligomerization
F542_RS02875	COG0791	NLP P60 protein
F542_RS02880	COG2932	Transcriptional regulator
F542_RS02890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F542_RS02895	COG0561	phosphatase activity
F542_RS02905	COG1074	ATP-dependent DNA helicase activity
F542_RS02915	COG0210	DNA helicase
F542_RS02965	COG0860	N-Acetylmuramoyl-L-alanine amidase
F542_RS02965	COG1388	LysM domain
F542_RS02970	COG0802	atpase or kinase
F542_RS02985	COG1519	Transferase
F542_RS03000	COG0795	lipopolysaccharide-transporting ATPase activity
F542_RS03005	COG0795	lipopolysaccharide-transporting ATPase activity
F542_RS03020	COG1793	dna ligase
F542_RS03025	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F542_RS03030	COG1984	allophanate hydrolase subunit 2
F542_RS03035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F542_RS03040	COG1914	H( )-stimulated, divalent metal cation uptake system
F542_RS03045	COG3630	sodium ion export across plasma membrane
F542_RS03060	COG2824	Alkylphosphonate utilization operon protein PhnA
F542_RS03080	COG4232	protein-disulfide reductase activity
F542_RS03085	COG1126	abc transporter atp-binding protein
F542_RS03090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F542_RS03095	COG4215	(ABC) transporter
F542_RS03100	COG4160	amino acid transport
F542_RS03105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F542_RS03115	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F542_RS03120	COG1083	cytidylyl-transferase
F542_RS03135	COG3306	glycosyltransferase involved in LPS biosynthesis
F542_RS03145	COG1216	Glycosyl transferase, family 2
F542_RS03150	COG1216	Glycosyl transferase, family 2
F542_RS03155	COG2608	mercury ion transmembrane transporter activity
F542_RS03165	COG1305	Transglutaminase-like
F542_RS03170	COG1466	dna polymerase III delta subunit
F542_RS03175	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F542_RS03180	COG0495	leucyl-tRNA aminoacylation
F542_RS03190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F542_RS03195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F542_RS03200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F542_RS03220	COG4120	Belongs to the binding-protein-dependent transport system permease family
F542_RS03230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F542_RS03235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F542_RS03240	COG1862	Preprotein translocase
F542_RS03245	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F542_RS03250	COG0583	DNA-binding transcription factor activity
F542_RS03255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F542_RS03260	COG0251	oxidation-reduction process
F542_RS03265	COG1011	Hydrolase
F542_RS03270	COG0583	DNA-binding transcription factor activity
F542_RS03280	COG3118	belongs to the thioredoxin family
F542_RS03290	COG2608	mercury ion transmembrane transporter activity
F542_RS03300	COG0803	Belongs to the bacterial solute-binding protein 9 family
F542_RS03305	COG1121	(ABC) transporter
F542_RS03310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F542_RS03315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F542_RS03325	COG2259	Doxx family
F542_RS03335	COG1162	GTPase activity
F542_RS03345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F542_RS03350	COG0469	pyruvate kinase activity
F542_RS03355	COG2062	phosphohistidine phosphatase, SixA
F542_RS03360	COG0083	homoserine kinase activity
F542_RS03365	COG0527	aspartate kinase activity
F542_RS03365	COG0460	homoserine dehydrogenase
F542_RS03385	COG0583	DNA-binding transcription factor activity
F542_RS03390	COG0254	rRNA binding
F542_RS03405	COG1678	Uncharacterized ACR, COG1678
F542_RS03410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F542_RS03415	COG3056	Lipoprotein
F542_RS03420	COG0271	Belongs to the BolA IbaG family
F542_RS03430	COG3015	lipoprotein NlpE involved in copper resistance
F542_RS03435	COG4701	Protein of unknown function (DUF721)
F542_RS03450	COG0494	nUDIX hydrolase
F542_RS03455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F542_RS03460	COG0512	Glutamine amidotransferase of anthranilate synthase
F542_RS03465	COG1942	4-Oxalocrotonate Tautomerase
F542_RS03475	COG2354	Protein conserved in bacteria
F542_RS03480	COG2226	methyltransferase
F542_RS03485	COG4166	transmembrane transport
F542_RS03490	COG0601	transmembrane transport
F542_RS03495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F542_RS03500	COG4172	Belongs to the ABC transporter superfamily
F542_RS03515	COG1965	Belongs to the frataxin family
F542_RS03530	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
F542_RS03540	COG1136	(ABC) transporter
F542_RS03545	COG4591	ABC-type transport system involved in lipoprotein release permease component
F542_RS03550	COG2183	response to ionizing radiation
F542_RS03560	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F542_RS03565	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F542_RS03570	COG1408	metallophosphoesterase
F542_RS03575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F542_RS03580	COG0617	tRNA 3'-terminal CCA addition
F542_RS03590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F542_RS03595	COG1027	Aspartate ammonia-lyase
F542_RS03600	COG1216	Glycosyl transferase, family 2
F542_RS03620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F542_RS03630	COG0859	PFAM glycosyl transferase family 9
F542_RS03635	COG0463	Glycosyl transferase, family 2
F542_RS03640	COG1534	Rna-binding protein
F542_RS03645	COG0671	phosphoesterase, PA-phosphatase related
F542_RS03650	COG1940	carbohydrate kinase activity
F542_RS03660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F542_RS03665	COG0575	Belongs to the CDS family
F542_RS03670	COG0750	zinc metalloprotease
F542_RS03685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F542_RS03690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F542_RS03700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F542_RS03705	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F542_RS03710	COG1077	Cell shape determining protein MreB Mrl
F542_RS03715	COG1792	Involved in formation and maintenance of cell shape
F542_RS03720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F542_RS03725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F542_RS03730	COG1199	ATP-dependent helicase activity
F542_RS03735	COG1380	Effector of murein hydrolase LrgA
F542_RS03740	COG1346	cytolysis
F542_RS03745	COG1132	(ABC) transporter
F542_RS03750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F542_RS03755	COG0670	Belongs to the BI1 family
F542_RS03760	COG2920	part of a sulfur-relay system
F542_RS03765	COG0859	PFAM glycosyl transferase family 9
F542_RS03770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F542_RS03775	COG1605	Chorismate mutase
F542_RS03775	COG0287	Prephenate dehydrogenase
F542_RS03780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F542_RS03790	COG0251	oxidation-reduction process
F542_RS03795	COG1496	oxidoreductase activity
F542_RS03810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F542_RS03815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F542_RS03820	COG3092	negative regulation of chromosome organization
F542_RS03835	COG1607	acyl-coa hydrolase
F542_RS03840	COG2350	Protein conserved in bacteria
F542_RS03855	COG3026	antisigma factor binding
F542_RS03865	COG0318	PFAM AMP-dependent synthetase and ligase
F542_RS03870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F542_RS03875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F542_RS03880	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F542_RS03880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F542_RS03890	COG1518	maintenance of DNA repeat elements
F542_RS03935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F542_RS03940	COG1216	Glycosyl transferase, family 2
F542_RS03955	COG0531	amino acid
F542_RS03960	COG0646	methionine synthase
F542_RS03960	COG1410	methionine synthase
F542_RS03975	COG4774	siderophore transport
F542_RS03980	COG4178	(ABC) transporter
F542_RS03995	COG0586	Pfam SNARE associated Golgi protein
F542_RS04005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F542_RS04005	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F542_RS04015	COG2252	PERMEase
F542_RS04020	COG0626	cystathionine gamma-synthase activity
F542_RS04040	COG0631	protein serine/threonine phosphatase activity
F542_RS04045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F542_RS04080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F542_RS04085	COG1595	DNA-templated transcription, initiation
F542_RS04090	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
F542_RS04100	COG0302	gtp cyclohydrolase
F542_RS04110	COG0494	nUDIX hydrolase
F542_RS04125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F542_RS04130	COG0709	Synthesizes selenophosphate from selenide and ATP
F542_RS04135	COG2867	negative regulation of translational initiation
F542_RS04140	COG2914	Belongs to the UPF0125 (RnfH) family
F542_RS04145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F542_RS04155	COG3691	Protein conserved in bacteria
F542_RS04160	COG1959	2 iron, 2 sulfur cluster binding
F542_RS04170	COG0822	iron-sulfur transferase activity
F542_RS04200	COG0633	Ferredoxin
F542_RS04205	COG2975	iron-sulfur cluster assembly
F542_RS04210	COG1686	Belongs to the peptidase S11 family
F542_RS04215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F542_RS04240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F542_RS04245	COG0142	geranyltranstransferase activity
F542_RS04250	COG1722	exodeoxyribonuclease VII activity
F542_RS04255	COG0633	Ferredoxin
F542_RS04255	COG3217	Mosc domain protein beta barrel domain protein
F542_RS04260	COG1946	Acyl-CoA thioesterase
F542_RS04270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F542_RS04270	COG0678	peroxiredoxin activity
F542_RS04275	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F542_RS04285	COG2840	Smr protein MutS2
F542_RS04290	COG0697	spore germination
F542_RS04295	COG0784	Response regulator, receiver
F542_RS04295	COG2198	Histidine kinase
F542_RS04295	COG5002	protein histidine kinase activity
F542_RS04305	COG4785	May be involved in cell division
F542_RS04310	COG0513	Belongs to the DEAD box helicase family
F542_RS04315	COG0590	tRNA wobble adenosine to inosine editing
F542_RS04325	COG0508	dehydrogenase complex catalyzes the overall conversion of
F542_RS04330	COG0567	Dehydrogenase, E1 component
F542_RS04335	COG0814	amino acid
F542_RS04340	COG1760	l-serine dehydratase
F542_RS04345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F542_RS04350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F542_RS04355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F542_RS04360	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F542_RS04360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F542_RS04375	COG0859	PFAM glycosyl transferase family 9
F542_RS04385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F542_RS04400	COG0305	Participates in initiation and elongation during chromosome replication
F542_RS04410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F542_RS04415	COG1620	l-lactate permease
F542_RS04420	COG0247	lactate metabolic process
F542_RS04425	COG1139	Iron-sulfur cluster binding protein
F542_RS04430	COG1556	Lactate utilization protein
F542_RS04435	COG0243	molybdopterin cofactor binding
F542_RS04455	COG2226	methyltransferase
F542_RS04460	COG3036	rescue of stalled ribosome
F542_RS04470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F542_RS04475	COG0840	transmembrane signaling receptor activity
F542_RS04480	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F542_RS04485	COG3052	prosthetic group binding
F542_RS04490	COG2301	Belongs to the HpcH HpaI aldolase family
F542_RS04495	COG3051	citrate lyase alpha subunit
F542_RS04500	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F542_RS04500	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
F542_RS04505	COG0471	metal ion transport
F542_RS04510	COG0538	isocitrate dehydrogenase activity
F542_RS04520	COG0372	Belongs to the citrate synthase family
F542_RS04525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F542_RS04530	COG0577	efflux transmembrane transporter activity
F542_RS04530	COG1136	(ABC) transporter
F542_RS04535	COG2205	protein histidine kinase activity
F542_RS04540	COG0745	RESPONSE REGULATOR receiver
F542_RS04545	COG3956	TIGRFAM MazG family protein
F542_RS04550	COG0248	Ppx GppA phosphatase
F542_RS04570	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
F542_RS04595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F542_RS04600	COG0058	SHG alpha-glucan phosphorylase activity
F542_RS04615	COG3074	FtsZ-dependent cytokinesis
F542_RS04620	COG2363	Small membrane protein
F542_RS04635	COG0626	cystathionine gamma-synthase activity
F542_RS04640	COG2226	methyltransferase
F542_RS04645	COG3094	Invasion gene expression up-regulator, SirB
F542_RS04655	COG0312	modulator of DNA gyrase
F542_RS04670	COG0737	Belongs to the 5'-nucleotidase family
F542_RS04675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F542_RS04685	COG0658	competence protein
F542_RS04685	COG2333	competence protein COMEC
F542_RS04690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F542_RS04690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F542_RS04695	COG1448	Aminotransferase
F542_RS04705	COG0433	COG0433 Predicted ATPase
F542_RS04715	COG0513	Belongs to the DEAD box helicase family
F542_RS04740	COG0564	pseudouridine synthase activity
F542_RS04750	COG3047	cAMP biosynthetic process
F542_RS04765	COG0517	IMP dehydrogenase activity
F542_RS04765	COG0516	GMP reductase activity
F542_RS04775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F542_RS04780	COG1523	belongs to the glycosyl hydrolase 13 family
F542_RS04785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F542_RS04790	COG0672	)-iron permease
F542_RS04795	COG2837	iron assimilation
F542_RS04800	COG2822	iron ion transport
F542_RS04820	COG1494	fructose-1,6-bisphosphatase
F542_RS04835	COG0195	Participates in both transcription termination and antitermination
F542_RS04860	COG0542	response to heat
F542_RS04865	COG0617	tRNA 3'-terminal CCA addition
F542_RS04875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F542_RS04880	COG2814	Major facilitator Superfamily
F542_RS04890	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F542_RS04895	COG1131	(ABC) transporter
F542_RS04900	COG0842	Transport permease protein
F542_RS04905	COG0737	Belongs to the 5'-nucleotidase family
F542_RS04910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F542_RS04925	COG0440	acetolactate synthase activity
F542_RS04930	COG0028	Belongs to the TPP enzyme family
F542_RS04935	COG0280	phosphate acetyltransferase
F542_RS04935	COG0281	malic enzyme
F542_RS04940	COG2831	hemolysin activation secretion protein
F542_RS04945	COG3210	domain, Protein
F542_RS04945	COG3210	domain, Protein
F542_RS04955	COG3210	domain, Protein
F542_RS04960	COG0814	amino acid
F542_RS04965	COG0741	lytic transglycosylase activity
F542_RS04970	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F542_RS04980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F542_RS04985	COG1943	Transposase
F542_RS04995	COG0732	type I restriction modification DNA specificity domain
F542_RS05000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F542_RS05025	COG3283	Transcriptional regulator of aromatic amino acids metabolism
F542_RS05030	COG4166	transmembrane transport
F542_RS05035	COG4168	peptide transport system, permease
F542_RS05040	COG4171	peptide transport system, permease
F542_RS05045	COG4172	Belongs to the ABC transporter superfamily
F542_RS05050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F542_RS05070	COG1349	DNA-binding transcription factor activity
F542_RS05075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F542_RS05085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F542_RS05090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F542_RS05095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F542_RS05110	COG3005	denitrification pathway
F542_RS05125	COG0243	molybdopterin cofactor binding
F542_RS05130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F542_RS05135	COG0730	response to heat
F542_RS05140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F542_RS05145	COG1309	transcriptional regulator
F542_RS05150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F542_RS05155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F542_RS05170	COG0596	Alpha beta hydrolase
F542_RS05180	COG0318	PFAM AMP-dependent synthetase and ligase
F542_RS05185	COG3264	Mechanosensitive ion channel
F542_RS05185	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F542_RS05215	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F542_RS05230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F542_RS05235	COG0508	dehydrogenase complex catalyzes the overall conversion of
F542_RS05240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F542_RS05245	COG0589	response to stress
F542_RS05255	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F542_RS05260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F542_RS05265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F542_RS05275	COG0539	negative regulation of cytoplasmic translation
F542_RS05285	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F542_RS05290	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F542_RS05300	COG0023	Translation Initiation Factor
F542_RS05305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F542_RS05310	COG1846	Transcriptional regulator
F542_RS05310	COG1940	carbohydrate kinase activity
F542_RS05315	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F542_RS05325	COG0857	belongs to the CobB CobQ family
F542_RS05325	COG0280	phosphate acetyltransferase
F542_RS05330	COG0277	FAD linked oxidase domain protein
F542_RS05335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F542_RS05360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F542_RS05365	COG0138	bifunctional purine biosynthesis protein purh
F542_RS05370	COG0151	Belongs to the GarS family
F542_RS05380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F542_RS05395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F542_RS05405	COG0006	proline dipeptidase activity
F542_RS05415	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
F542_RS05420	COG0527	aspartate kinase activity
F542_RS05425	COG1214	PFAM Peptidase M22, glycoprotease
F542_RS05430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F542_RS05435	COG2321	neutral zinc metallopeptidase
F542_RS05445	COG1674	ftsk spoiiie
F542_RS05450	COG1522	sequence-specific DNA binding
F542_RS05455	COG0814	amino acid
F542_RS05460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F542_RS05470	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F542_RS05490	COG4783	chaperone-mediated protein folding
F542_RS05510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F542_RS05520	COG3381	protein complex oligomerization
F542_RS05525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F542_RS05525	COG2221	Nitrite and sulphite reductase 4Fe-4S
F542_RS05530	COG0243	molybdopterin cofactor binding
F542_RS05535	COG0437	4 iron, 4 sulfur cluster binding
F542_RS05540	COG3302	dmso reductase anchor subunit
F542_RS05555	COG1917	Cupin 2, conserved barrel domain protein
F542_RS05555	COG4977	sequence-specific DNA binding
F542_RS05560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F542_RS05570	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F542_RS05580	COG2969	positive regulation of protein catabolic process
F542_RS05585	COG0625	glutathione transferase activity
F542_RS05595	COG2951	lytic endotransglycosylase activity
F542_RS05600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F542_RS05610	COG1116	anion transmembrane transporter activity
F542_RS05615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F542_RS05620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F542_RS05630	COG0351	phosphomethylpyrimidine kinase
F542_RS05640	COG0477	Major facilitator Superfamily
F542_RS05660	COG3383	formate dehydrogenase (NAD+) activity
F542_RS05660	COG0243	molybdopterin cofactor binding
F542_RS05665	COG3383	formate dehydrogenase (NAD+) activity
F542_RS05665	COG0243	molybdopterin cofactor binding
F542_RS05670	COG0437	4 iron, 4 sulfur cluster binding
F542_RS05675	COG2864	formate dehydrogenase
F542_RS05680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F542_RS05685	COG4988	ABC transporter
F542_RS05690	COG2911	Protein conserved in bacteria
F542_RS05695	COG0729	surface antigen
F542_RS05700	COG4942	peptidase
F542_RS05710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F542_RS05720	COG3105	Protein conserved in bacteria
F542_RS05725	COG0629	single-stranded DNA binding
F542_RS05730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F542_RS05735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F542_RS05740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F542_RS05750	COG0556	nucleotide-excision repair
F542_RS05770	COG0556	nucleotide-excision repair
F542_RS05775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F542_RS05785	COG5645	(Lipo)protein
F542_RS05800	COG2358	TRAP transporter, solute receptor (TAXI family
F542_RS05815	COG0425	Belongs to the sulfur carrier protein TusA family
F542_RS05820	COG3945	hemerythrin HHE cation binding domain
F542_RS05845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F542_RS05850	COG0561	phosphatase activity
F542_RS05860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F542_RS05865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F542_RS05870	COG0739	heme binding
F542_RS05875	COG1121	(ABC) transporter
F542_RS05880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F542_RS05885	COG0121	glutamine amidotransferase
F542_RS05890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F542_RS05895	COG1879	ABC-type sugar transport system periplasmic component
F542_RS05900	COG1444	tRNA N-acetyltransferase activity
F542_RS05905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F542_RS05910	COG0314	molybdopterin synthase activity
F542_RS05915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F542_RS05920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F542_RS05925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F542_RS05930	COG0285	dihydrofolate synthase activity
F542_RS05935	COG0613	PHP domain protein
F542_RS05945	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
F542_RS05950	COG2925	Exonuclease
F542_RS05965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F542_RS05995	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F542_RS06010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F542_RS06030	COG1278	Cold shock
F542_RS06035	COG0288	reversible hydration of carbon dioxide
F542_RS06045	COG3083	sulfuric ester hydrolase activity
F542_RS06050	COG0791	NLP P60 protein
F542_RS06070	COG1392	Phosphate transport regulator
F542_RS06075	COG0306	phosphate transporter
F542_RS06080	COG4991	sh3 domain protein
F542_RS06085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F542_RS06090	COG1530	ribonuclease E activity
F542_RS06095	COG0602	queuosine metabolic process
F542_RS06100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F542_RS06100	COG1328	CTP reductase activity
F542_RS06105	COG1944	ATP diphosphatase activity
F542_RS06110	COG1509	lysine 2,3-aminomutase activity
F542_RS06130	COG1737	Transcriptional regulator
F542_RS06135	COG2731	YhcH YjgK YiaL family protein
F542_RS06140	COG0708	Exodeoxyribonuclease III
F542_RS06145	COG2056	Na+-H+ antiporter family
F542_RS06150	COG0037	tRNA processing
F542_RS06165	COG0183	Belongs to the thiolase family
F542_RS06190	COG3210	domain, Protein
F542_RS06195	COG1286	toxin biosynthetic process
F542_RS06200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F542_RS06205	COG4608	Belongs to the ABC transporter superfamily
F542_RS06210	COG0444	Belongs to the ABC transporter superfamily
F542_RS06220	COG0747	negative chemotaxis
F542_RS06225	COG0328	RNA-DNA hybrid ribonuclease activity
F542_RS06235	COG1757	Na H antiporter
F542_RS06240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F542_RS06245	COG4969	Belongs to the N-Me-Phe pilin family
F542_RS06250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F542_RS06255	COG1459	type II secretion system
F542_RS06265	COG0237	dephospho-CoA kinase activity
F542_RS06270	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F542_RS06280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F542_RS06285	COG1660	Displays ATPase and GTPase activities
F542_RS06290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F542_RS06295	COG1137	ATPase activity
F542_RS06300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F542_RS06310	COG2949	membrane
F542_RS06315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F542_RS06320	COG1381	Involved in DNA repair and RecF pathway recombination
F542_RS06335	COG0681	Belongs to the peptidase S26 family
F542_RS06345	COG1115	amino acid carrier protein
F542_RS06350	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F542_RS06355	COG3683	transport system, periplasmic component
F542_RS06370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F542_RS06375	COG4149	molybdate abc transporter
F542_RS06380	COG0725	ABC transporter, periplasmic molybdate-binding protein
F542_RS06395	COG2005	Transcriptional regulator
F542_RS06400	COG0159	tryptophan synthase activity
F542_RS06410	COG0489	protein tyrosine kinase activity
F542_RS06415	COG4166	transmembrane transport
F542_RS06420	COG2095	MarC family integral membrane protein
F542_RS06425	COG1187	pseudouridine synthase activity
F542_RS06430	COG2814	Major facilitator Superfamily
F542_RS06445	COG4221	oxidoreductase activity
F542_RS06450	COG2983	Belongs to the UPF0260 family
F542_RS06455	COG0393	Putative heavy-metal-binding
F542_RS06460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F542_RS06465	COG1560	Kdo2-lipid A biosynthetic process
F542_RS06470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F542_RS06475	COG2066	Belongs to the glutaminase family
F542_RS06500	COG1643	Atp-dependent helicase
F542_RS06510	COG0330	HflC and HflK could
F542_RS06515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F542_RS06520	COG3106	COG3106 Predicted ATPase
F542_RS06525	COG3025	triphosphatase activity
F542_RS06535	COG0564	pseudouridine synthase activity
F542_RS06540	COG3098	single-species biofilm formation
F542_RS06545	COG0134	indole-3-glycerol-phosphate synthase activity
F542_RS06545	COG0135	phosphoribosylanthranilate isomerase activity
F542_RS06555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F542_RS06560	COG0303	'Molybdopterin
F542_RS06565	COG2095	MarC family integral membrane protein
F542_RS06570	COG0488	(ABC) transporter
F542_RS06575	COG2610	gluconate transmembrane transporter activity
F542_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
F542_RS06585	COG0183	Belongs to the thiolase family
F542_RS06590	COG2031	fatty acid transporter
F542_RS06595	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F542_RS06600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F542_RS06605	COG0583	DNA-binding transcription factor activity
F542_RS06625	COG1704	LemA family
F542_RS06640	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F542_RS06645	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F542_RS06650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F542_RS06655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F542_RS06665	COG0823	Involved in the tonB-independent uptake of proteins
F542_RS06670	COG3064	Membrane
F542_RS06675	COG0848	biopolymer transport protein
F542_RS06680	COG0811	peptide transport
F542_RS06685	COG0824	Thioesterase
F542_RS06695	COG1294	oxidase, subunit
F542_RS06700	COG1271	oxidase subunit
F542_RS06705	COG3071	HemY protein
F542_RS06710	COG2959	enzyme of heme biosynthesis
F542_RS06720	COG0181	hydroxymethylbilane synthase activity
F542_RS06725	COG1115	amino acid carrier protein
F542_RS06745	COG0497	DNA recombination
F542_RS06750	COG2081	HI0933 family
F542_RS06755	COG0697	spore germination
F542_RS06760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F542_RS06775	COG1609	Transcriptional regulator
F542_RS06780	COG2268	Band 7 protein
F542_RS06785	COG2841	Protein conserved in bacteria
F542_RS06800	COG2965	DNA replication, synthesis of RNA primer
F542_RS06815	COG0425	Belongs to the sulfur carrier protein TusA family
F542_RS06820	COG2391	methyltransferase activity
F542_RS06875	COG2831	hemolysin activation secretion protein
F542_RS06880	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F542_RS06885	COG1525	nuclease
F542_RS06890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F542_RS06895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F542_RS06905	COG0301	tRNA thio-modification
F542_RS06905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F542_RS06910	COG1538	Outer membrane efflux protein
F542_RS06915	COG0194	GDP metabolic process
F542_RS06920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F542_RS06925	COG2195	Cleaves the N-terminal amino acid of tripeptides
F542_RS06930	COG2801	Transposase and inactivated derivatives
F542_RS06990	COG1373	ATPase (AAA superfamily
F542_RS07035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F542_RS07045	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F542_RS07050	COG1349	DNA-binding transcription factor activity
F542_RS07055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F542_RS07060	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
F542_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
F542_RS07080	COG3730	PTS system glucitol sorbitol-specific
F542_RS07085	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F542_RS07090	COG0720	synthase
F542_RS07095	COG0602	queuosine metabolic process
F542_RS07100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F542_RS07110	COG0778	Nitroreductase
F542_RS07115	COG4172	Belongs to the ABC transporter superfamily
F542_RS07120	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
F542_RS07125	COG0191	fructose-bisphosphate aldolase activity
F542_RS07130	COG0126	phosphoglycerate kinase activity
F542_RS07135	COG0471	metal ion transport
F542_RS07140	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F542_RS07145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F542_RS07150	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F542_RS07155	COG4133	protoheme IX ABC transporter activity
F542_RS07160	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F542_RS07165	COG3201	nicotinamide mononucleotide transporter
F542_RS07170	COG2976	Protein conserved in bacteria
F542_RS07180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F542_RS07185	COG1426	Protein conserved in bacteria
F542_RS07200	COG0747	negative chemotaxis
F542_RS07205	COG0601	transmembrane transport
F542_RS07210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F542_RS07215	COG4172	Belongs to the ABC transporter superfamily
F542_RS07225	COG0012	GTP binding
F542_RS07235	COG1216	Glycosyl transferase, family 2
F542_RS07240	COG0513	Belongs to the DEAD box helicase family
F542_RS07245	COG0456	acetyltransferase
F542_RS07265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F542_RS07270	COG0488	(ABC) transporter
F542_RS07285	COG2911	Protein conserved in bacteria
F542_RS07295	COG0346	lactoylglutathione lyase activity
F542_RS07300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F542_RS07310	COG4771	TonB-dependent receptor
F542_RS07310	COG1629	transport
F542_RS07315	COG3842	ATPase activity
F542_RS07320	COG1176	ABC-type spermidine putrescine transport system, permease component I
F542_RS07325	COG1177	transmembrane transport
F542_RS07335	COG2255	four-way junction helicase activity
F542_RS07350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F542_RS07370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F542_RS07375	COG0616	signal peptide processing
F542_RS07385	COG0811	peptide transport
F542_RS07395	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F542_RS07400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F542_RS07405	COG1328	CTP reductase activity
F542_RS07425	COG0210	DNA helicase
F542_RS07430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F542_RS07440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F542_RS07445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F542_RS07455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F542_RS07465	COG1649	PFAM Uncharacterised BCR, COG1649
F542_RS07465	COG0726	polysaccharide deacetylase
F542_RS07470	COG1215	transferase activity, transferring glycosyl groups
F542_RS07480	COG3739	integral membrane protein
F542_RS07485	COG1694	Mazg nucleotide pyrophosphohydrolase
F542_RS07495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F542_RS07500	COG0616	signal peptide processing
F542_RS07505	COG0778	Nitroreductase
F542_RS07510	COG3101	peptidyl-lysine hydroxylation
F542_RS07515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F542_RS07520	COG2853	Lipoprotein
F542_RS07525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F542_RS07530	COG3108	Peptidase M15
F542_RS07535	COG2989	Protein conserved in bacteria
F542_RS07540	COG0793	Belongs to the peptidase S41A family
F542_RS07545	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F542_RS07550	COG0492	ferredoxin-NADP+ reductase activity
F542_RS07555	COG3118	belongs to the thioredoxin family
F542_RS07575	COG1090	epimerase
F542_RS07580	COG0564	pseudouridine synthase activity
F542_RS07585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F542_RS07590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F542_RS07595	COG1560	Kdo2-lipid A biosynthetic process
F542_RS07620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F542_RS07625	COG4656	Part of a membrane complex involved in electron transport
F542_RS07625	COG4656	Part of a membrane complex involved in electron transport
F542_RS07635	COG4657	Part of a membrane complex involved in electron transport
F542_RS07650	COG1120	ATPase activity
F542_RS07655	COG0482	sulfurtransferase activity
F542_RS07670	COG1942	4-Oxalocrotonate Tautomerase
F542_RS07675	COG2991	Protein conserved in bacteria
F542_RS07680	COG1477	protein flavinylation
F542_RS07685	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F542_RS07690	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F542_RS07695	COG2871	sodium ion transport
F542_RS07700	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F542_RS07705	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F542_RS07710	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F542_RS07715	COG1805	sodium ion transport
F542_RS07725	COG0316	Belongs to the HesB IscA family
F542_RS07725	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F542_RS07730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F542_RS07735	COG0747	negative chemotaxis
F542_RS07740	COG0747	negative chemotaxis
F542_RS07745	COG0601	transmembrane transport
F542_RS07750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F542_RS07755	COG0444	Belongs to the ABC transporter superfamily
F542_RS07765	COG4608	Belongs to the ABC transporter superfamily
F542_RS07770	COG0471	metal ion transport
F542_RS07775	COG1169	isochorismate synthase
F542_RS07780	COG0436	Aminotransferase
F542_RS07795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F542_RS07800	COG1840	ABC-type Fe3 transport system, periplasmic component
F542_RS07810	COG3842	ATPase activity
F542_RS07815	COG0563	adenylate kinase activity
F542_RS07825	COG4607	ABC-type enterochelin transport system periplasmic component
F542_RS07830	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F542_RS07835	COG4605	iron ion homeostasis
F542_RS07840	COG4604	ABC transporter, ATP-binding protein
F542_RS07845	COG2814	Major facilitator Superfamily
F542_RS07855	COG1187	pseudouridine synthase activity
F542_RS07860	COG1605	Chorismate mutase
F542_RS07860	COG0077	Prephenate dehydratase
F542_RS07865	COG1216	Glycosyl transferase, family 2
F542_RS07870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F542_RS07880	COG0339	signal peptide processing
F542_RS07885	COG1454	alcohol dehydrogenase
F542_RS07885	COG1012	belongs to the aldehyde dehydrogenase family
F542_RS07890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F542_RS07900	COG1882	Formate acetyltransferase
F542_RS07905	COG2116	formate transmembrane transporter activity
F542_RS07910	COG0494	nUDIX hydrolase
F542_RS07920	COG1218	3'(2'),5'-bisphosphate nucleotidase
F542_RS07925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F542_RS07930	COG0363	glucosamine-6-phosphate deaminase activity
F542_RS07940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F542_RS07965	COG5413	integral membrane protein
F542_RS07980	COG4206	TonB-dependent receptor
F542_RS08000	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
F542_RS08020	COG0308	aminopeptidase N
F542_RS08030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F542_RS08035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F542_RS08040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F542_RS08045	COG0196	riboflavin kinase activity
F542_RS08080	COG0826	peptidase U32
F542_RS08085	COG4178	(ABC) transporter
F542_RS08090	COG0612	Peptidase, M16
F542_RS08095	COG4771	TonB-dependent receptor
F542_RS08125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F542_RS08130	COG0849	cell division
F542_RS08140	COG1181	Belongs to the D-alanine--D-alanine ligase family
F542_RS08155	COG0772	Belongs to the SEDS family
F542_RS08160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F542_RS08165	COG1397	ADP-ribosylglycohydrolase
F542_RS08170	COG1280	lysine exporter protein (LysE YggA)
F542_RS08180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F542_RS08185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F542_RS08195	COG0768	penicillin binding
F542_RS08200	COG3116	cell division
F542_RS08225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F542_RS08240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F542_RS08240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F542_RS08245	COG1105	Belongs to the carbohydrate kinase PfkB family
F542_RS08250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F542_RS08250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F542_RS08250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F542_RS08255	COG1794	racemase activity, acting on amino acids and derivatives
F542_RS08270	COG1640	4-alpha-glucanotransferase
F542_RS08275	COG0058	SHG alpha-glucan phosphorylase activity
F542_RS08280	COG2909	trisaccharide binding
F542_RS08285	COG0366	Alpha amylase catalytic
F542_RS08290	COG3833	ABC-type maltose transport systems, permease component
F542_RS08295	COG1175	transmembrane transport
F542_RS08300	COG2182	Extracellular solute-binding protein
F542_RS08305	COG3842	ATPase activity
F542_RS08310	COG4580	involved in the transport of maltose and maltodextrins
F542_RS08320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F542_RS08325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F542_RS08330	COG1217	gtp-binding protein TYPA
F542_RS08335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F542_RS08340	COG0747	negative chemotaxis
F542_RS08345	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F542_RS08350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F542_RS08355	COG0557	exoribonuclease II activity
F542_RS08360	COG1045	serine acetyltransferase
F542_RS08375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F542_RS08385	COG1652	LysM domain
F542_RS08395	COG0107	imidazoleglycerol-phosphate synthase activity
F542_RS08405	COG2852	Protein conserved in bacteria
F542_RS08415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F542_RS08425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F542_RS08425	COG0131	Imidazoleglycerol-phosphate dehydratase
F542_RS08470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F542_RS08475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F542_RS08485	COG0537	adenosine 5'-monophosphoramidase activity
F542_RS08520	COG0330	HflC and HflK could
F542_RS08525	COG0330	HflC and HflK could
F542_RS08540	COG3301	Polysulphide reductase, NrfD
F542_RS08545	COG0437	4 iron, 4 sulfur cluster binding
F542_RS08550	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F542_RS08570	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F542_RS08575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F542_RS08580	COG1178	ABC-type Fe3 transport system permease component
F542_RS08585	COG0569	domain protein
F542_RS08590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F542_RS08615	COG1739	Uncharacterized protein family UPF0029
F542_RS08640	COG1595	DNA-templated transcription, initiation
F542_RS08645	COG3219	Protein conserved in bacteria
F542_RS08660	COG2259	Doxx family
F542_RS08665	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F542_RS08670	COG0439	Biotin carboxylase
F542_RS08675	COG0511	ligase activity, forming carbon-carbon bonds
F542_RS08680	COG1840	ABC-type Fe3 transport system, periplasmic component
F542_RS08685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F542_RS08695	COG1253	flavin adenine dinucleotide binding
F542_RS08700	COG0686	Belongs to the AlaDH PNT family
F542_RS08705	COG0733	neurotransmitter:sodium symporter activity
F542_RS08720	COG1399	metal-binding, possibly nucleic acid-binding protein
F542_RS08730	COG0416	fatty acid biosynthetic process
F542_RS08735	COG0789	Transcriptional regulator
F542_RS08740	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F542_RS08775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F542_RS08805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F542_RS08810	COG0385	Bile acid
F542_RS08815	COG3719	Belongs to the RNase T2 family
F542_RS08825	COG2391	methyltransferase activity
F542_RS08830	COG0425	Belongs to the sulfur carrier protein TusA family
F542_RS08845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F542_RS08855	COG3030	protein affecting phage T7 exclusion by the F plasmid
F542_RS08880	COG2927	DNA polymerase III (CHI subunit)
F542_RS08885	COG2153	protein acetylation
F542_RS08900	COG0525	valine-tRNA ligase activity
F542_RS08920	COG1530	ribonuclease E activity
F542_RS08925	COG0668	transmembrane transport
F542_RS08930	COG1114	Component of the transport system for branched-chain amino acids
F542_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
F542_RS08940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F542_RS08945	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F542_RS08950	COG0142	geranyltranstransferase activity
F542_RS08955	COG4536	flavin adenine dinucleotide binding
F542_RS08960	COG4137	Cytochrome C assembly protein
F542_RS08975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F542_RS09040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F542_RS09050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F542_RS09055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F542_RS09070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F542_RS09080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F542_RS09085	COG1858	cytochrome C peroxidase
F542_RS09090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F542_RS09110	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F542_RS09115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F542_RS09180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F542_RS09185	COG4558	Periplasmic binding protein
F542_RS09190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F542_RS09210	COG1629	transport
F542_RS09210	COG4206	TonB-dependent receptor
F542_RS09215	COG1053	succinate dehydrogenase
F542_RS09220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F542_RS09230	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F542_RS09250	COG3700	Belongs to the class B bacterial acid phosphatase family
F542_RS09255	COG1522	sequence-specific DNA binding
F542_RS09280	COG1755	Isoprenylcysteine carboxyl methyltransferase
F542_RS09290	COG2852	Protein conserved in bacteria
F542_RS09295	COG4545	Glutaredoxin-related protein
F542_RS09305	COG1268	BioY protein
F542_RS09315	COG2850	peptidyl-arginine hydroxylation
F542_RS09325	COG0084	hydrolase, TatD family'
F542_RS09330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F542_RS09335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F542_RS09380	COG0490	domain, Protein
F542_RS09380	COG0471	metal ion transport
F542_RS09385	COG1858	cytochrome C peroxidase
F542_RS09390	COG1876	peptidase activity
F542_RS09395	COG0742	ribosomal rna small subunit methyltransferase
F542_RS09400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F542_RS09405	COG0594	ribonuclease P activity
F542_RS09410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F542_RS09440	COG3835	regulator
F542_RS09445	COG2610	gluconate transmembrane transporter activity
F542_RS09450	COG1929	Belongs to the glycerate kinase type-1 family
F542_RS09460	COG0737	Belongs to the 5'-nucleotidase family
F542_RS09465	COG0716	FMN binding
F542_RS09475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F542_RS09480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F542_RS09485	COG3084	Protein conserved in bacteria
F542_RS09495	COG3722	fumarate hydratase activity
F542_RS09505	COG2213	PTS system mannitol-specific
F542_RS09505	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F542_RS09510	COG3085	chromosome segregation
F542_RS09545	COG0037	tRNA processing
F542_RS09550	COG1902	pentaerythritol trinitrate reductase activity
F542_RS09565	COG0728	peptidoglycan biosynthetic process
F542_RS09570	COG2116	formate transmembrane transporter activity
F542_RS09575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F542_RS09610	COG0470	DNA polymerase III
F542_RS09625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F542_RS09655	COG1561	YicC-like family, N-terminal region
F542_RS09660	COG0675	Transposase, IS605 OrfB family
F542_RS09665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F542_RS09665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F542_RS09670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F542_RS09675	COG0583	DNA-binding transcription factor activity
F542_RS09680	COG1309	transcriptional regulator
F542_RS09685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F542_RS09690	COG0095	Lipoate-protein ligase
F542_RS09695	COG2272	Belongs to the type-B carboxylesterase lipase family
F542_RS09705	COG1073	alpha beta
F542_RS09715	COG0656	L-ascorbic acid biosynthetic process
F542_RS09735	COG0673	inositol 2-dehydrogenase activity
F542_RS09740	COG1064	alcohol dehydrogenase
F542_RS09745	COG0778	Nitroreductase
F542_RS09750	COG1902	pentaerythritol trinitrate reductase activity
F542_RS09755	COG0583	DNA-binding transcription factor activity
F542_RS09760	COG2962	Rard protein
F542_RS09765	COG3070	regulator of competence-specific genes
F542_RS09805	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F542_RS09815	COG0583	DNA-binding transcription factor activity
F542_RS09825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F542_RS09855	COG1067	ATP-dependent peptidase activity
F542_RS09860	COG3120	sequence-specific DNA binding
F542_RS09865	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F542_RS09865	COG2885	chlorophyll binding
F542_RS09875	COG0247	lactate metabolic process
F542_RS09875	COG0277	FAD linked oxidase domain protein
F542_RS09885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F542_RS09915	COG3721	Heme iron utilization protein
F542_RS09920	COG0748	coenzyme F420 binding
F542_RS09925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F542_RS09930	COG0606	chelatase, subunit chli
F542_RS09935	COG0443	Heat shock 70 kDa protein
F542_RS09950	COG0745	RESPONSE REGULATOR receiver
F542_RS09955	COG0295	cytidine deaminase activity
F542_RS09960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F542_RS09975	COG0076	glutamate decarboxylase activity
F542_RS09985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F542_RS09990	COG2050	protein possibly involved in aromatic compounds catabolism
F542_RS09995	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F542_RS10005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F542_RS10020	COG0521	Mo-molybdopterin cofactor biosynthetic process
F542_RS10025	COG2832	Protein of unknown function (DUF454)
F542_RS10030	COG1215	transferase activity, transferring glycosyl groups
F542_RS10035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F542_RS10050	COG0180	Tryptophanyl-tRNA synthetase
F542_RS10065	COG3265	gluconokinase activity
F542_RS10070	COG2610	gluconate transmembrane transporter activity
F542_RS10075	COG0561	phosphatase activity
F542_RS10085	COG3716	PTS system mannose fructose sorbose family IID component
F542_RS10090	COG3715	PTS system
F542_RS10095	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F542_RS10095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F542_RS10100	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F542_RS10125	COG3623	hexulose-6-phosphate isomerase
F542_RS10130	COG0235	Class ii aldolase
F542_RS10140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F542_RS10150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F542_RS10165	COG3276	selenocysteine insertion sequence binding
F542_RS10170	COG2168	tRNA wobble position uridine thiolation
F542_RS10180	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F542_RS10185	COG2964	Protein conserved in bacteria
F542_RS10190	COG0545	Peptidyl-prolyl cis-trans isomerase
F542_RS10200	COG3111	PFAM Bacterial OB fold (BOF) protein
F542_RS10215	COG1846	Transcriptional regulator
F542_RS10225	COG1733	regulation of RNA biosynthetic process
F542_RS10230	COG2249	NAD(P)H dehydrogenase (quinone) activity
F542_RS10235	COG4589	Belongs to the CDS family
F542_RS10300	COG2814	Major facilitator Superfamily
F542_RS10305	COG2259	Doxx family
F542_RS10310	COG0583	DNA-binding transcription factor activity
F542_RS10375	COG1902	pentaerythritol trinitrate reductase activity
F542_RS10375	COG0446	pyridine nucleotide-disulphide oxidoreductase
F542_RS10385	COG3836	Belongs to the HpcH HpaI aldolase family
F542_RS10390	COG2249	NAD(P)H dehydrogenase (quinone) activity
F542_RS10395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F542_RS10400	COG1764	response to oxidative stress
F542_RS10435	COG2190	(PTS) system
F542_RS10435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F542_RS10435	COG1263	PTS System
F542_RS10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F542_RS10445	COG1879	ABC-type sugar transport system periplasmic component
F542_RS10450	COG1172	Belongs to the binding-protein-dependent transport system permease family
F542_RS10470	COG1609	Transcriptional regulator
F542_RS10480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F542_RS10485	COG0506	proline dehydrogenase activity
F542_RS10485	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F542_RS10485	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F542_RS10500	COG1902	pentaerythritol trinitrate reductase activity
F542_RS10515	COG0583	DNA-binding transcription factor activity
F542_RS10535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F542_RS10560	COG3118	belongs to the thioredoxin family
F542_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
F542_RS10570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F542_RS10590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F542_RS10625	COG1752	Esterase of the alpha-beta hydrolase superfamily
F542_RS10630	COG1285	pathogenesis
F542_RS10635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F542_RS10640	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F542_RS10660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F542_RS10670	COG0356	it plays a direct role in the translocation of protons across the membrane
F542_RS10685	COG1178	ABC-type Fe3 transport system permease component
F542_RS10690	COG3842	ATPase activity
F542_RS10705	COG0357	Ribosomal RNA small subunit methyltransferase G
F542_RS10715	COG0445	tRNA wobble uridine modification
F542_RS10720	COG2264	protein methyltransferase activity
F542_RS10740	COG3210	domain, Protein
F542_RS10775	COG3210	domain, Protein