locus-tag	class	description
F543_RS00010	COG0799	negative regulation of ribosome biogenesis
F543_RS00015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F543_RS00020	COG0768	penicillin binding
F543_RS00025	COG0772	Belongs to the SEDS family
F543_RS00035	COG1686	Belongs to the peptidase S11 family
F543_RS00055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F543_RS00060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F543_RS00060	COG1263	PTS System
F543_RS00060	COG2190	(PTS) system
F543_RS00070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F543_RS00075	COG3962	Belongs to the TPP enzyme family
F543_RS00085	COG0673	inositol 2-dehydrogenase activity
F543_RS00095	COG0673	inositol 2-dehydrogenase activity
F543_RS00100	COG1172	Belongs to the binding-protein-dependent transport system permease family
F543_RS00105	COG1129	ABC transporter
F543_RS00120	COG3718	enzyme involved in inositol metabolism
F543_RS00130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F543_RS00135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F543_RS00140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F543_RS00150	COG1414	Transcriptional regulator
F543_RS00175	COG1194	a g-specific adenine glycosylase
F543_RS00180	COG0346	lactoylglutathione lyase activity
F543_RS00190	COG3477	response to acidic pH
F543_RS00195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F543_RS00200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F543_RS00205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F543_RS00220	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
F543_RS00230	COG0019	diaminopimelate decarboxylase activity
F543_RS00235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F543_RS00250	COG0081	regulation of translation
F543_RS00255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F543_RS00265	COG0085	RNA polymerase activity
F543_RS00285	COG2814	Major facilitator Superfamily
F543_RS00300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F543_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
F543_RS00315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F543_RS00340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F543_RS00420	COG0642	Histidine kinase
F543_RS00425	COG0745	RESPONSE REGULATOR receiver
F543_RS00445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F543_RS00460	COG1609	Transcriptional regulator
F543_RS00470	COG0259	pyridoxamine-phosphate oxidase activity
F543_RS00480	COG0758	DNA mediated transformation
F543_RS00515	COG4974	Belongs to the 'phage' integrase family
F543_RS00520	COG0431	NADPH-dependent FMN reductase
F543_RS00550	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F543_RS00560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F543_RS00580	COG3177	Filamentation induced by cAMP protein fic
F543_RS00595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F543_RS00615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F543_RS00620	COG0730	response to heat
F543_RS00635	COG0204	Acyl-transferase
F543_RS00660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F543_RS00665	COG1022	Amp-dependent synthetase and ligase
F543_RS00670	COG0765	amino acid transport
F543_RS00675	COG1126	abc transporter atp-binding protein
F543_RS00685	COG1970	mechanosensitive ion channel activity
F543_RS00690	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
F543_RS00695	COG2226	methyltransferase
F543_RS00725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F543_RS00730	COG0805	protein transport
F543_RS00755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F543_RS00760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F543_RS00770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F543_RS00775	COG0051	transcription antitermination factor activity, RNA binding
F543_RS00785	COG0088	Forms part of the polypeptide exit tunnel
F543_RS00790	COG0089	rRNA binding
F543_RS00800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F543_RS00805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F543_RS00810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F543_RS00820	COG0255	Belongs to the universal ribosomal protein uL29 family
F543_RS00830	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F543_RS00845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F543_RS00855	COG0582	viral genome integration into host DNA
F543_RS00885	COG5532	Uncharacterized conserved protein (DUF2303)
F543_RS00975	COG1403	HNH endonuclease
F543_RS01010	COG3617	BRO family, N-terminal domain
F543_RS01020	COG3772	lysozyme
F543_RS01055	COG0740	serine-type endopeptidase activity
F543_RS01165	COG0545	Peptidyl-prolyl cis-trans isomerase
F543_RS01200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F543_RS01215	COG0598	Magnesium transport protein CorA
F543_RS01230	COG0859	PFAM glycosyl transferase family 9
F543_RS01240	COG3266	domain, Protein
F543_RS01240	COG3061	Opacity-associated protein A
F543_RS01245	COG1555	photosystem II stabilization
F543_RS01255	COG0494	nUDIX hydrolase
F543_RS01270	COG2818	Glycosylase
F543_RS01280	COG1388	LysM domain
F543_RS01280	COG4942	peptidase
F543_RS01290	COG1238	metal cluster binding
F543_RS01295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F543_RS01305	COG0149	triose-phosphate isomerase activity
F543_RS01330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F543_RS01335	COG1393	Belongs to the ArsC family
F543_RS01340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F543_RS01365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F543_RS01370	COG3172	ATPase kinase involved in NAD metabolism
F543_RS01375	COG2129	metallophosphoesterase
F543_RS01385	COG1289	transmembrane transporter activity
F543_RS01395	COG3133	Outer membrane lipoprotein
F543_RS01400	COG3102	Protein conserved in bacteria
F543_RS01405	COG0018	arginyl-trna synthetase
F543_RS01425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F543_RS01435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F543_RS01445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F543_RS01455	COG0200	Binds to the 23S rRNA
F543_RS01460	COG0201	protein transport
F543_RS01470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F543_RS01485	COG0202	RNA polymerase activity
F543_RS01495	COG0228	four-way junction DNA binding
F543_RS01515	COG1476	TRANSCRIPTIONal
F543_RS01530	COG0252	asparaginase activity
F543_RS01555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F543_RS01560	COG2003	Belongs to the UPF0758 family
F543_RS01570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F543_RS01585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F543_RS01595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F543_RS01600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F543_RS01605	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
F543_RS01610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F543_RS01615	COG0546	phosphoglycolate phosphatase activity
F543_RS01630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F543_RS01640	COG0742	ribosomal rna small subunit methyltransferase
F543_RS01645	COG0552	protein localization to endoplasmic reticulum
F543_RS01650	COG2884	Cell division ATP-binding protein ftsE
F543_RS01655	COG2177	Part of the ABC transporter FtsEX involved in
F543_RS01660	COG4774	siderophore transport
F543_RS01665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F543_RS01675	COG1120	ATPase activity
F543_RS01685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F543_RS01690	COG1584	GPR1 FUN34 yaaH family protein
F543_RS01695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F543_RS01695	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F543_RS01700	COG3715	PTS system
F543_RS01705	COG3716	PTS system mannose fructose sorbose family IID component
F543_RS01710	COG4811	Protein of unknown function (DUF986)
F543_RS01715	COG1482	cell wall glycoprotein biosynthetic process
F543_RS01730	COG1840	ABC-type Fe3 transport system, periplasmic component
F543_RS01735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F543_RS01745	COG1349	DNA-binding transcription factor activity
F543_RS01750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F543_RS01755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F543_RS01765	COG3012	SEC-C Motif Domain Protein
F543_RS01785	COG3681	Belongs to the UPF0597 family
F543_RS01790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F543_RS01795	COG2190	(PTS) system
F543_RS01800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F543_RS01805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F543_RS01810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F543_RS01815	COG3593	DNA synthesis involved in DNA repair
F543_RS01820	COG1611	Belongs to the LOG family
F543_RS01845	COG0564	pseudouridine synthase activity
F543_RS01850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F543_RS01855	COG1621	beta-fructofuranosidase activity
F543_RS01865	COG0733	neurotransmitter:sodium symporter activity
F543_RS01920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F543_RS01930	COG3590	peptidase
F543_RS01935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F543_RS01945	COG0628	permease
F543_RS01960	COG4771	TonB-dependent receptor
F543_RS01965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F543_RS01970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F543_RS01975	COG3171	Protein conserved in bacteria
F543_RS01980	COG0762	integral membrane protein
F543_RS01990	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F543_RS02000	COG4145	pantothenate transmembrane transporter activity
F543_RS02015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F543_RS02030	COG0583	DNA-binding transcription factor activity
F543_RS02035	COG3266	domain, Protein
F543_RS02040	COG0697	spore germination
F543_RS02060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F543_RS02070	COG1720	tRNA m6t6A37 methyltransferase activity
F543_RS02075	COG1575	Belongs to the MenA family. Type 1 subfamily
F543_RS02085	COG2723	6-phospho-beta-galactosidase activity
F543_RS02105	COG0564	pseudouridine synthase activity
F543_RS02110	COG0534	Mate efflux family protein
F543_RS02120	COG1132	(ABC) transporter
F543_RS02130	COG3008	intermembrane lipid transfer
F543_RS02135	COG0735	belongs to the Fur family
F543_RS02140	COG0716	FMN binding
F543_RS02150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F543_RS02155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F543_RS02160	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F543_RS02165	COG2252	PERMEase
F543_RS02170	COG3099	Belongs to the UPF0263 family
F543_RS02190	COG2995	paraquat-inducible protein a
F543_RS02200	COG0354	folic acid binding
F543_RS02205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F543_RS02220	COG0560	Phosphoserine phosphatase
F543_RS02245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F543_RS02250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F543_RS02260	COG0009	L-threonylcarbamoyladenylate synthase
F543_RS02265	COG0640	Transcriptional regulator
F543_RS02275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F543_RS02285	COG0446	pyridine nucleotide-disulphide oxidoreductase
F543_RS02310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F543_RS02310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F543_RS02330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F543_RS02340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F543_RS02355	COG1322	Protein conserved in bacteria
F543_RS02360	COG0512	Glutamine amidotransferase of anthranilate synthase
F543_RS02375	COG2166	iron-sulfur cluster assembly
F543_RS02385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F543_RS02390	COG1663	tetraacyldisaccharide 4'-kinase activity
F543_RS02395	COG2835	tetraacyldisaccharide 4'-kinase activity
F543_RS02400	COG0084	hydrolase, TatD family'
F543_RS02405	COG1040	competence protein
F543_RS02410	COG0561	phosphatase activity
F543_RS02415	COG4783	chaperone-mediated protein folding
F543_RS02420	COG1263	PTS System
F543_RS02420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F543_RS02425	COG0366	Alpha amylase catalytic
F543_RS02440	COG1280	lysine exporter protein (LysE YggA)
F543_RS02445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F543_RS02450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F543_RS02455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F543_RS02460	COG4796	Type ii and iii secretion system protein
F543_RS02485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F543_RS02490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F543_RS02495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F543_RS02500	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F543_RS02510	COG2431	L-lysine efflux transmembrane transporter activity
F543_RS02565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F543_RS02570	COG1966	Carbon starvation protein
F543_RS02575	COG2801	Transposase and inactivated derivatives
F543_RS02580	COG0516	GMP reductase activity
F543_RS02590	COG2960	long-chain fatty acid transporting porin activity
F543_RS02620	COG0009	L-threonylcarbamoyladenylate synthase
F543_RS02625	COG0551	DNA topoisomerase type I activity
F543_RS02635	COG2137	regulation of response to DNA damage stimulus
F543_RS02645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F543_RS02655	COG4143	(ABC) transporter
F543_RS02660	COG1702	phosphate starvation-inducible protein PhoH
F543_RS02665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F543_RS02670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F543_RS02670	COG0517	IMP dehydrogenase activity
F543_RS02690	COG1335	isochorismatase
F543_RS02710	COG4235	cytochrome complex assembly
F543_RS02710	COG3088	subunit of a heme lyase
F543_RS02715	COG4235	cytochrome complex assembly
F543_RS02715	COG3088	subunit of a heme lyase
F543_RS02720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F543_RS02730	COG1138	Cytochrome C-type biogenesis protein
F543_RS02735	COG0475	glutathione-regulated potassium exporter activity
F543_RS02735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F543_RS02745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F543_RS02750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F543_RS02755	COG3392	D12 class N6 adenine-specific DNA methyltransferase
F543_RS02770	COG5301	cellulose 1,4-beta-cellobiosidase activity
F543_RS02775	COG3778	Protein conserved in bacteria
F543_RS02780	COG3299	homolog of phage Mu protein gp47
F543_RS02785	COG4381	Mu-like prophage protein gp46
F543_RS02790	COG4384	Bacteriophage Mu Gp45 protein
F543_RS02805	COG4228	DNA circulation
F543_RS02810	COG3941	tape measure
F543_RS02815	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
F543_RS02835	COG5003	unkown
F543_RS02840	COG4387	Mu-like prophage protein GP36
F543_RS02850	COG4397	Mu-like prophage major head subunit gpT
F543_RS02855	COG4388	Caudovirus prohead serine protease
F543_RS02860	COG5005	Phage virion morphogenesis
F543_RS02865	COG2369	cell adhesion
F543_RS02870	COG4383	Mu-like prophage protein gp29
F543_RS02875	COG4373	Mu-like prophage FluMu protein gp28
F543_RS02885	COG0640	Transcriptional regulator
F543_RS02895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F543_RS02915	COG3023	N-Acetylmuramoyl-L-alanine amidase
F543_RS02925	COG5566	PFAM Mor transcription activator
F543_RS02935	COG4382	Mu-like prophage protein Gp16
F543_RS02950	COG4396	Host-nuclease inhibitor protein Gam
F543_RS02965	COG2842	Transposition protein
F543_RS02970	COG2801	Transposase and inactivated derivatives
F543_RS02975	COG3423	Transcriptional regulator
F543_RS02985	COG0247	lactate metabolic process
F543_RS02995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F543_RS03000	COG0584	glycerophosphoryl diester phosphodiesterase
F543_RS03005	COG2271	Major facilitator Superfamily
F543_RS03010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F543_RS03020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F543_RS03025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F543_RS03025	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
F543_RS03035	COG0243	molybdopterin cofactor binding
F543_RS03040	COG0437	4 iron, 4 sulfur cluster binding
F543_RS03045	COG0348	domain, Protein
F543_RS03050	COG3043	anaerobic respiration
F543_RS03055	COG3005	denitrification pathway
F543_RS03060	COG2990	Protein conserved in bacteria
F543_RS03070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F543_RS03075	COG0024	Methionine aminopeptidase
F543_RS03080	COG0783	Belongs to the Dps family
F543_RS03095	COG0792	nuclease activity
F543_RS03100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F543_RS03110	COG1127	ABC transporter
F543_RS03115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F543_RS03120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F543_RS03125	COG2854	intermembrane phospholipid transfer
F543_RS03135	COG5007	Belongs to the BolA IbaG family
F543_RS03150	COG1138	Cytochrome C-type biogenesis protein
F543_RS03160	COG1640	4-alpha-glucanotransferase
F543_RS03170	COG0187	DNA topoisomerase II activity
F543_RS03200	COG0488	(ABC) transporter
F543_RS03210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F543_RS03220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F543_RS03225	COG1129	ABC transporter
F543_RS03225	COG0842	Transport permease protein
F543_RS03230	COG0842	Transport permease protein
F543_RS03240	COG0402	S-adenosylhomocysteine deaminase activity
F543_RS03245	COG3023	N-Acetylmuramoyl-L-alanine amidase
F543_RS03250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F543_RS03255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F543_RS03260	COG0705	Rhomboid family
F543_RS03265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F543_RS03290	COG3550	peptidyl-serine autophosphorylation
F543_RS03325	COG1410	methionine synthase
F543_RS03325	COG0646	methionine synthase
F543_RS03330	COG0676	glucose-6-phosphate 1-epimerase activity
F543_RS03340	COG3068	Protein conserved in bacteria
F543_RS03370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F543_RS03400	COG4591	ABC-type transport system involved in lipoprotein release permease component
F543_RS03410	COG3381	protein complex oligomerization
F543_RS03420	COG0791	NLP P60 protein
F543_RS03425	COG2932	Transcriptional regulator
F543_RS03435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F543_RS03440	COG0561	phosphatase activity
F543_RS03450	COG1074	ATP-dependent DNA helicase activity
F543_RS03460	COG0210	DNA helicase
F543_RS03495	COG1388	LysM domain
F543_RS03495	COG0860	N-Acetylmuramoyl-L-alanine amidase
F543_RS03500	COG0802	atpase or kinase
F543_RS03515	COG1519	Transferase
F543_RS03530	COG0795	lipopolysaccharide-transporting ATPase activity
F543_RS03535	COG0795	lipopolysaccharide-transporting ATPase activity
F543_RS03550	COG1793	dna ligase
F543_RS03555	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F543_RS03560	COG1984	allophanate hydrolase subunit 2
F543_RS03565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F543_RS03570	COG1914	H( )-stimulated, divalent metal cation uptake system
F543_RS03575	COG3630	sodium ion export across plasma membrane
F543_RS03590	COG2824	Alkylphosphonate utilization operon protein PhnA
F543_RS03610	COG4232	protein-disulfide reductase activity
F543_RS03615	COG1126	abc transporter atp-binding protein
F543_RS03620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F543_RS03625	COG4215	(ABC) transporter
F543_RS03630	COG4160	amino acid transport
F543_RS03635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F543_RS03645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F543_RS03650	COG1083	cytidylyl-transferase
F543_RS03665	COG3306	glycosyltransferase involved in LPS biosynthesis
F543_RS03675	COG1216	Glycosyl transferase, family 2
F543_RS03680	COG1216	Glycosyl transferase, family 2
F543_RS03685	COG2608	mercury ion transmembrane transporter activity
F543_RS03695	COG1305	Transglutaminase-like
F543_RS03700	COG1466	dna polymerase III delta subunit
F543_RS03705	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F543_RS03710	COG0495	leucyl-tRNA aminoacylation
F543_RS03720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F543_RS03725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F543_RS03730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F543_RS03750	COG4120	Belongs to the binding-protein-dependent transport system permease family
F543_RS03760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F543_RS03765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F543_RS03770	COG1862	Preprotein translocase
F543_RS03775	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F543_RS03780	COG0583	DNA-binding transcription factor activity
F543_RS03785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F543_RS03790	COG0251	oxidation-reduction process
F543_RS03795	COG1011	Hydrolase
F543_RS03800	COG0583	DNA-binding transcription factor activity
F543_RS03810	COG3118	belongs to the thioredoxin family
F543_RS03820	COG2608	mercury ion transmembrane transporter activity
F543_RS03830	COG0803	Belongs to the bacterial solute-binding protein 9 family
F543_RS03835	COG1121	(ABC) transporter
F543_RS03845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F543_RS03855	COG2259	Doxx family
F543_RS03865	COG1162	GTPase activity
F543_RS03875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F543_RS03880	COG0469	pyruvate kinase activity
F543_RS03885	COG2062	phosphohistidine phosphatase, SixA
F543_RS03895	COG0527	aspartate kinase activity
F543_RS03895	COG0460	homoserine dehydrogenase
F543_RS03915	COG0583	DNA-binding transcription factor activity
F543_RS03920	COG0254	rRNA binding
F543_RS03935	COG1678	Uncharacterized ACR, COG1678
F543_RS03940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F543_RS03945	COG3056	Lipoprotein
F543_RS03950	COG0271	Belongs to the BolA IbaG family
F543_RS03960	COG3015	lipoprotein NlpE involved in copper resistance
F543_RS03965	COG4701	Protein of unknown function (DUF721)
F543_RS03980	COG0494	nUDIX hydrolase
F543_RS03990	COG0512	Glutamine amidotransferase of anthranilate synthase
F543_RS03995	COG1942	4-Oxalocrotonate Tautomerase
F543_RS04005	COG2354	Protein conserved in bacteria
F543_RS04010	COG2226	methyltransferase
F543_RS04015	COG4166	transmembrane transport
F543_RS04020	COG0601	transmembrane transport
F543_RS04025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F543_RS04030	COG4172	Belongs to the ABC transporter superfamily
F543_RS04045	COG1965	Belongs to the frataxin family
F543_RS04060	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
F543_RS04070	COG1136	(ABC) transporter
F543_RS04075	COG4591	ABC-type transport system involved in lipoprotein release permease component
F543_RS04080	COG2183	response to ionizing radiation
F543_RS04090	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F543_RS04095	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F543_RS04100	COG1408	metallophosphoesterase
F543_RS04105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F543_RS04110	COG0617	tRNA 3'-terminal CCA addition
F543_RS04120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F543_RS04125	COG1027	Aspartate ammonia-lyase
F543_RS04130	COG1216	Glycosyl transferase, family 2
F543_RS04150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F543_RS04160	COG0859	PFAM glycosyl transferase family 9
F543_RS04165	COG0463	Glycosyl transferase, family 2
F543_RS04170	COG1534	Rna-binding protein
F543_RS04175	COG0671	phosphoesterase, PA-phosphatase related
F543_RS04180	COG1940	carbohydrate kinase activity
F543_RS04190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F543_RS04195	COG0575	Belongs to the CDS family
F543_RS04200	COG0750	zinc metalloprotease
F543_RS04215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F543_RS04220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F543_RS04230	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F543_RS04235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F543_RS04240	COG1077	Cell shape determining protein MreB Mrl
F543_RS04250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F543_RS04255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F543_RS04265	COG1380	Effector of murein hydrolase LrgA
F543_RS04270	COG1346	cytolysis
F543_RS04275	COG1132	(ABC) transporter
F543_RS04280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F543_RS04285	COG0670	Belongs to the BI1 family
F543_RS04290	COG2920	part of a sulfur-relay system
F543_RS04295	COG0859	PFAM glycosyl transferase family 9
F543_RS04300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F543_RS04305	COG1605	Chorismate mutase
F543_RS04305	COG0287	Prephenate dehydrogenase
F543_RS04310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F543_RS04320	COG0251	oxidation-reduction process
F543_RS04325	COG1496	oxidoreductase activity
F543_RS04340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F543_RS04345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F543_RS04350	COG3092	negative regulation of chromosome organization
F543_RS04365	COG1607	acyl-coa hydrolase
F543_RS04370	COG2350	Protein conserved in bacteria
F543_RS04385	COG3026	antisigma factor binding
F543_RS04395	COG0318	PFAM AMP-dependent synthetase and ligase
F543_RS04400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F543_RS04405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F543_RS04410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F543_RS04410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F543_RS04420	COG1518	maintenance of DNA repeat elements
F543_RS04465	COG1216	Glycosyl transferase, family 2
F543_RS04480	COG0531	amino acid
F543_RS04485	COG1410	methionine synthase
F543_RS04485	COG0646	methionine synthase
F543_RS04505	COG4178	(ABC) transporter
F543_RS04520	COG0586	Pfam SNARE associated Golgi protein
F543_RS04530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F543_RS04530	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F543_RS04540	COG2252	PERMEase
F543_RS04565	COG0631	protein serine/threonine phosphatase activity
F543_RS04570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F543_RS04605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F543_RS04610	COG1595	DNA-templated transcription, initiation
F543_RS04615	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
F543_RS04625	COG0302	gtp cyclohydrolase
F543_RS04635	COG0494	nUDIX hydrolase
F543_RS04650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F543_RS04655	COG0709	Synthesizes selenophosphate from selenide and ATP
F543_RS04660	COG2867	negative regulation of translational initiation
F543_RS04665	COG2914	Belongs to the UPF0125 (RnfH) family
F543_RS04670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F543_RS04680	COG3691	Protein conserved in bacteria
F543_RS04685	COG1959	2 iron, 2 sulfur cluster binding
F543_RS04695	COG0822	iron-sulfur transferase activity
F543_RS04725	COG0633	Ferredoxin
F543_RS04730	COG2975	iron-sulfur cluster assembly
F543_RS04740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F543_RS04765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F543_RS04770	COG0142	geranyltranstransferase activity
F543_RS04775	COG1722	exodeoxyribonuclease VII activity
F543_RS04780	COG3217	Mosc domain protein beta barrel domain protein
F543_RS04780	COG0633	Ferredoxin
F543_RS04785	COG1946	Acyl-CoA thioesterase
F543_RS04795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F543_RS04795	COG0678	peroxiredoxin activity
F543_RS04800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F543_RS04810	COG2840	Smr protein MutS2
F543_RS04820	COG5002	protein histidine kinase activity
F543_RS04820	COG0784	Response regulator, receiver
F543_RS04820	COG2198	Histidine kinase
F543_RS04830	COG4785	May be involved in cell division
F543_RS04835	COG0513	Belongs to the DEAD box helicase family
F543_RS04840	COG0590	tRNA wobble adenosine to inosine editing
F543_RS04850	COG0508	dehydrogenase complex catalyzes the overall conversion of
F543_RS04855	COG0567	Dehydrogenase, E1 component
F543_RS04860	COG0814	amino acid
F543_RS04865	COG1760	l-serine dehydratase
F543_RS04870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F543_RS04875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F543_RS04880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F543_RS04885	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F543_RS04885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F543_RS04905	COG0859	PFAM glycosyl transferase family 9
F543_RS04915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F543_RS04940	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F543_RS04945	COG1620	l-lactate permease
F543_RS04950	COG0247	lactate metabolic process
F543_RS04955	COG1139	Iron-sulfur cluster binding protein
F543_RS04960	COG1556	Lactate utilization protein
F543_RS04965	COG0243	molybdopterin cofactor binding
F543_RS04985	COG2226	methyltransferase
F543_RS04990	COG3036	rescue of stalled ribosome
F543_RS05000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F543_RS05005	COG0840	transmembrane signaling receptor activity
F543_RS05010	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F543_RS05015	COG3052	prosthetic group binding
F543_RS05020	COG2301	Belongs to the HpcH HpaI aldolase family
F543_RS05025	COG3051	citrate lyase alpha subunit
F543_RS05030	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F543_RS05030	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
F543_RS05035	COG0471	metal ion transport
F543_RS05040	COG0538	isocitrate dehydrogenase activity
F543_RS05050	COG0372	Belongs to the citrate synthase family
F543_RS05055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F543_RS05060	COG1136	(ABC) transporter
F543_RS05060	COG0577	efflux transmembrane transporter activity
F543_RS05065	COG2205	protein histidine kinase activity
F543_RS05070	COG0745	RESPONSE REGULATOR receiver
F543_RS05075	COG3956	TIGRFAM MazG family protein
F543_RS05080	COG0248	Ppx GppA phosphatase
F543_RS05100	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
F543_RS05125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F543_RS05130	COG0058	SHG alpha-glucan phosphorylase activity
F543_RS05145	COG3074	FtsZ-dependent cytokinesis
F543_RS05150	COG2363	Small membrane protein
F543_RS05165	COG0626	cystathionine gamma-synthase activity
F543_RS05175	COG3094	Invasion gene expression up-regulator, SirB
F543_RS05185	COG0312	modulator of DNA gyrase
F543_RS05200	COG0737	Belongs to the 5'-nucleotidase family
F543_RS05205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F543_RS05215	COG2333	competence protein COMEC
F543_RS05215	COG0658	competence protein
F543_RS05220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F543_RS05220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F543_RS05225	COG1448	Aminotransferase
F543_RS05235	COG0433	COG0433 Predicted ATPase
F543_RS05270	COG0564	pseudouridine synthase activity
F543_RS05280	COG3047	cAMP biosynthetic process
F543_RS05295	COG0516	GMP reductase activity
F543_RS05295	COG0517	IMP dehydrogenase activity
F543_RS05305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F543_RS05310	COG1523	belongs to the glycosyl hydrolase 13 family
F543_RS05315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F543_RS05320	COG0672	)-iron permease
F543_RS05325	COG2837	iron assimilation
F543_RS05330	COG2822	iron ion transport
F543_RS05350	COG1494	fructose-1,6-bisphosphatase
F543_RS05365	COG0195	Participates in both transcription termination and antitermination
F543_RS05390	COG0542	response to heat
F543_RS05395	COG0617	tRNA 3'-terminal CCA addition
F543_RS05405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F543_RS05410	COG2814	Major facilitator Superfamily
F543_RS05425	COG1131	(ABC) transporter
F543_RS05430	COG0842	Transport permease protein
F543_RS05455	COG0440	acetolactate synthase activity
F543_RS05460	COG0028	Belongs to the TPP enzyme family
F543_RS05465	COG0281	malic enzyme
F543_RS05465	COG0280	phosphate acetyltransferase
F543_RS05470	COG2831	hemolysin activation secretion protein
F543_RS05475	COG3210	domain, Protein
F543_RS05475	COG3210	domain, Protein
F543_RS05485	COG3210	domain, Protein
F543_RS05495	COG0741	lytic transglycosylase activity
F543_RS05500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F543_RS05510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F543_RS05515	COG1943	Transposase
F543_RS05525	COG0732	type I restriction modification DNA specificity domain
F543_RS05530	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F543_RS05560	COG3283	Transcriptional regulator of aromatic amino acids metabolism
F543_RS05565	COG4166	transmembrane transport
F543_RS05575	COG4171	peptide transport system, permease
F543_RS05580	COG4172	Belongs to the ABC transporter superfamily
F543_RS05585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F543_RS05605	COG1349	DNA-binding transcription factor activity
F543_RS05610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F543_RS05620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F543_RS05625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F543_RS05630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F543_RS05645	COG3005	denitrification pathway
F543_RS05660	COG0243	molybdopterin cofactor binding
F543_RS05665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F543_RS05670	COG0730	response to heat
F543_RS05675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F543_RS05680	COG1309	transcriptional regulator
F543_RS05685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F543_RS05690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F543_RS05705	COG0596	Alpha beta hydrolase
F543_RS05715	COG0318	PFAM AMP-dependent synthetase and ligase
F543_RS05750	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F543_RS05765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F543_RS05780	COG0589	response to stress
F543_RS05790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F543_RS05795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F543_RS05800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F543_RS05810	COG0539	negative regulation of cytoplasmic translation
F543_RS05820	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F543_RS05825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F543_RS05835	COG0023	Translation Initiation Factor
F543_RS05840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F543_RS05845	COG1940	carbohydrate kinase activity
F543_RS05845	COG1846	Transcriptional regulator
F543_RS05850	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F543_RS05860	COG0280	phosphate acetyltransferase
F543_RS05860	COG0857	belongs to the CobB CobQ family
F543_RS05865	COG0277	FAD linked oxidase domain protein
F543_RS05870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F543_RS05895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F543_RS05900	COG0138	bifunctional purine biosynthesis protein purh
F543_RS05905	COG0151	Belongs to the GarS family
F543_RS05915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F543_RS05940	COG0006	proline dipeptidase activity
F543_RS05950	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
F543_RS05955	COG0527	aspartate kinase activity
F543_RS05960	COG1214	PFAM Peptidase M22, glycoprotease
F543_RS05965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F543_RS05970	COG2321	neutral zinc metallopeptidase
F543_RS05980	COG1674	ftsk spoiiie
F543_RS05985	COG1522	sequence-specific DNA binding
F543_RS05990	COG0814	amino acid
F543_RS05995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F543_RS06005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F543_RS06025	COG4783	chaperone-mediated protein folding
F543_RS06045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F543_RS06055	COG3381	protein complex oligomerization
F543_RS06060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F543_RS06060	COG2221	Nitrite and sulphite reductase 4Fe-4S
F543_RS06065	COG0243	molybdopterin cofactor binding
F543_RS06070	COG0437	4 iron, 4 sulfur cluster binding
F543_RS06075	COG3302	dmso reductase anchor subunit
F543_RS06090	COG4977	sequence-specific DNA binding
F543_RS06090	COG1917	Cupin 2, conserved barrel domain protein
F543_RS06115	COG2969	positive regulation of protein catabolic process
F543_RS06120	COG0625	glutathione transferase activity
F543_RS06130	COG2951	lytic endotransglycosylase activity
F543_RS06135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F543_RS06145	COG1116	anion transmembrane transporter activity
F543_RS06150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F543_RS06155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F543_RS06165	COG0351	phosphomethylpyrimidine kinase
F543_RS06175	COG0477	Major facilitator Superfamily
F543_RS06195	COG0243	molybdopterin cofactor binding
F543_RS06195	COG3383	formate dehydrogenase (NAD+) activity
F543_RS06205	COG0437	4 iron, 4 sulfur cluster binding
F543_RS06210	COG2864	formate dehydrogenase
F543_RS06215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F543_RS06220	COG4988	ABC transporter
F543_RS06225	COG2911	Protein conserved in bacteria
F543_RS06235	COG4942	peptidase
F543_RS06245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F543_RS06255	COG3105	Protein conserved in bacteria
F543_RS06260	COG0629	single-stranded DNA binding
F543_RS06265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F543_RS06270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F543_RS06275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F543_RS06285	COG0556	nucleotide-excision repair
F543_RS06305	COG0556	nucleotide-excision repair
F543_RS06310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F543_RS06320	COG5645	(Lipo)protein
F543_RS06335	COG2358	TRAP transporter, solute receptor (TAXI family
F543_RS06350	COG0425	Belongs to the sulfur carrier protein TusA family
F543_RS06355	COG3945	hemerythrin HHE cation binding domain
F543_RS06380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F543_RS06385	COG0561	phosphatase activity
F543_RS06395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F543_RS06400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F543_RS06405	COG0739	heme binding
F543_RS06410	COG1121	(ABC) transporter
F543_RS06415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F543_RS06425	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F543_RS06430	COG1879	ABC-type sugar transport system periplasmic component
F543_RS06435	COG1444	tRNA N-acetyltransferase activity
F543_RS06445	COG0314	molybdopterin synthase activity
F543_RS06450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F543_RS06455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F543_RS06460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F543_RS06465	COG0285	dihydrofolate synthase activity
F543_RS06470	COG0613	PHP domain protein
F543_RS06480	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
F543_RS06500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F543_RS06530	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F543_RS06545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F543_RS06565	COG1278	Cold shock
F543_RS06570	COG0288	reversible hydration of carbon dioxide
F543_RS06580	COG3083	sulfuric ester hydrolase activity
F543_RS06585	COG0791	NLP P60 protein
F543_RS06605	COG1392	Phosphate transport regulator
F543_RS06610	COG0306	phosphate transporter
F543_RS06615	COG4991	sh3 domain protein
F543_RS06620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F543_RS06625	COG1530	ribonuclease E activity
F543_RS06630	COG0602	queuosine metabolic process
F543_RS06635	COG1328	CTP reductase activity
F543_RS06635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F543_RS06640	COG1944	ATP diphosphatase activity
F543_RS06645	COG1509	lysine 2,3-aminomutase activity
F543_RS06665	COG1737	Transcriptional regulator
F543_RS06670	COG2731	YhcH YjgK YiaL family protein
F543_RS06675	COG0708	Exodeoxyribonuclease III
F543_RS06680	COG2056	Na+-H+ antiporter family
F543_RS06700	COG0183	Belongs to the thiolase family
F543_RS06735	COG3210	domain, Protein
F543_RS06740	COG1286	toxin biosynthetic process
F543_RS06745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F543_RS06750	COG4608	Belongs to the ABC transporter superfamily
F543_RS06755	COG0444	Belongs to the ABC transporter superfamily
F543_RS06765	COG0747	negative chemotaxis
F543_RS06770	COG0328	RNA-DNA hybrid ribonuclease activity
F543_RS06780	COG1757	Na H antiporter
F543_RS06785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F543_RS06790	COG4969	Belongs to the N-Me-Phe pilin family
F543_RS06795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F543_RS06810	COG0237	dephospho-CoA kinase activity
F543_RS06815	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F543_RS06825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F543_RS06830	COG1660	Displays ATPase and GTPase activities
F543_RS06835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F543_RS06840	COG1137	ATPase activity
F543_RS06845	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F543_RS06855	COG2949	membrane
F543_RS06860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F543_RS06865	COG1381	Involved in DNA repair and RecF pathway recombination
F543_RS06890	COG1115	amino acid carrier protein
F543_RS06895	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F543_RS06900	COG3683	transport system, periplasmic component
F543_RS06915	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F543_RS06925	COG0725	ABC transporter, periplasmic molybdate-binding protein
F543_RS06940	COG2005	Transcriptional regulator
F543_RS06945	COG0159	tryptophan synthase activity
F543_RS06955	COG0489	protein tyrosine kinase activity
F543_RS06960	COG4166	transmembrane transport
F543_RS06965	COG2095	MarC family integral membrane protein
F543_RS06970	COG1187	pseudouridine synthase activity
F543_RS06975	COG2814	Major facilitator Superfamily
F543_RS06990	COG4221	oxidoreductase activity
F543_RS06995	COG2983	Belongs to the UPF0260 family
F543_RS07000	COG0393	Putative heavy-metal-binding
F543_RS07005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F543_RS07010	COG1560	Kdo2-lipid A biosynthetic process
F543_RS07015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F543_RS07020	COG2066	Belongs to the glutaminase family
F543_RS07055	COG0330	HflC and HflK could
F543_RS07060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F543_RS07065	COG3106	COG3106 Predicted ATPase
F543_RS07070	COG3025	triphosphatase activity
F543_RS07080	COG0564	pseudouridine synthase activity
F543_RS07085	COG3098	single-species biofilm formation
F543_RS07090	COG0135	phosphoribosylanthranilate isomerase activity
F543_RS07090	COG0134	indole-3-glycerol-phosphate synthase activity
F543_RS07100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F543_RS07105	COG0303	'Molybdopterin
F543_RS07110	COG2095	MarC family integral membrane protein
F543_RS07115	COG0488	(ABC) transporter
F543_RS07120	COG2610	gluconate transmembrane transporter activity
F543_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
F543_RS07130	COG0183	Belongs to the thiolase family
F543_RS07135	COG2031	fatty acid transporter
F543_RS07140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F543_RS07145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F543_RS07150	COG0583	DNA-binding transcription factor activity
F543_RS07170	COG1704	LemA family
F543_RS07185	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F543_RS07190	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F543_RS07195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F543_RS07200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F543_RS07210	COG0823	Involved in the tonB-independent uptake of proteins
F543_RS07215	COG3064	Membrane
F543_RS07220	COG0848	biopolymer transport protein
F543_RS07225	COG0811	peptide transport
F543_RS07230	COG0824	Thioesterase
F543_RS07240	COG1294	oxidase, subunit
F543_RS07245	COG1271	oxidase subunit
F543_RS07250	COG3071	HemY protein
F543_RS07255	COG2959	enzyme of heme biosynthesis
F543_RS07265	COG0181	hydroxymethylbilane synthase activity
F543_RS07270	COG1115	amino acid carrier protein
F543_RS07290	COG0497	DNA recombination
F543_RS07295	COG2081	HI0933 family
F543_RS07300	COG0697	spore germination
F543_RS07305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F543_RS07320	COG1609	Transcriptional regulator
F543_RS07325	COG2268	Band 7 protein
F543_RS07330	COG2841	Protein conserved in bacteria
F543_RS07345	COG2965	DNA replication, synthesis of RNA primer
F543_RS07360	COG0425	Belongs to the sulfur carrier protein TusA family
F543_RS07365	COG2391	methyltransferase activity
F543_RS07425	COG2831	hemolysin activation secretion protein
F543_RS07430	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F543_RS07435	COG1525	nuclease
F543_RS07440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F543_RS07445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F543_RS07455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F543_RS07455	COG0301	tRNA thio-modification
F543_RS07460	COG1538	Outer membrane efflux protein
F543_RS07465	COG0194	GDP metabolic process
F543_RS07470	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F543_RS07475	COG2195	Cleaves the N-terminal amino acid of tripeptides
F543_RS07480	COG2963	transposase activity
F543_RS07485	COG2801	Transposase and inactivated derivatives
F543_RS07545	COG1373	ATPase (AAA superfamily
F543_RS07590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F543_RS07600	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F543_RS07605	COG1349	DNA-binding transcription factor activity
F543_RS07610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F543_RS07615	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
F543_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
F543_RS07635	COG3730	PTS system glucitol sorbitol-specific
F543_RS07640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F543_RS07645	COG0720	synthase
F543_RS07650	COG0602	queuosine metabolic process
F543_RS07655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F543_RS07665	COG0778	Nitroreductase
F543_RS07670	COG4172	Belongs to the ABC transporter superfamily
F543_RS07675	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
F543_RS07680	COG0191	fructose-bisphosphate aldolase activity
F543_RS07685	COG0126	phosphoglycerate kinase activity
F543_RS07690	COG0471	metal ion transport
F543_RS07695	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F543_RS07700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F543_RS07705	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F543_RS07710	COG4133	protoheme IX ABC transporter activity
F543_RS07715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F543_RS07720	COG3201	nicotinamide mononucleotide transporter
F543_RS07725	COG2976	Protein conserved in bacteria
F543_RS07735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F543_RS07740	COG1426	Protein conserved in bacteria
F543_RS07755	COG0747	negative chemotaxis
F543_RS07760	COG0601	transmembrane transport
F543_RS07765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F543_RS07770	COG4172	Belongs to the ABC transporter superfamily
F543_RS07780	COG0012	GTP binding
F543_RS07790	COG1216	Glycosyl transferase, family 2
F543_RS07795	COG0513	Belongs to the DEAD box helicase family
F543_RS07800	COG0456	acetyltransferase
F543_RS07820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F543_RS07825	COG0488	(ABC) transporter
F543_RS07845	COG2911	Protein conserved in bacteria
F543_RS07855	COG0346	lactoylglutathione lyase activity
F543_RS07860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F543_RS07870	COG1629	transport
F543_RS07870	COG4771	TonB-dependent receptor
F543_RS07875	COG3842	ATPase activity
F543_RS07880	COG1176	ABC-type spermidine putrescine transport system, permease component I
F543_RS07885	COG1177	transmembrane transport
F543_RS07895	COG2255	four-way junction helicase activity
F543_RS07910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F543_RS07930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F543_RS07935	COG0616	signal peptide processing
F543_RS07945	COG0811	peptide transport
F543_RS07955	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F543_RS07960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F543_RS07985	COG0210	DNA helicase
F543_RS07990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F543_RS08000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F543_RS08005	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F543_RS08015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F543_RS08025	COG1649	PFAM Uncharacterised BCR, COG1649
F543_RS08025	COG0726	polysaccharide deacetylase
F543_RS08030	COG1215	transferase activity, transferring glycosyl groups
F543_RS08040	COG3739	integral membrane protein
F543_RS08045	COG1694	Mazg nucleotide pyrophosphohydrolase
F543_RS08055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F543_RS08060	COG0616	signal peptide processing
F543_RS08065	COG0778	Nitroreductase
F543_RS08070	COG3101	peptidyl-lysine hydroxylation
F543_RS08075	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F543_RS08080	COG2853	Lipoprotein
F543_RS08085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F543_RS08090	COG3108	Peptidase M15
F543_RS08095	COG2989	Protein conserved in bacteria
F543_RS08100	COG0793	Belongs to the peptidase S41A family
F543_RS08105	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F543_RS08110	COG0492	ferredoxin-NADP+ reductase activity
F543_RS08115	COG3118	belongs to the thioredoxin family
F543_RS08135	COG1090	epimerase
F543_RS08140	COG0564	pseudouridine synthase activity
F543_RS08145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F543_RS08150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F543_RS08155	COG1560	Kdo2-lipid A biosynthetic process
F543_RS08175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F543_RS08185	COG4656	Part of a membrane complex involved in electron transport
F543_RS08195	COG4657	Part of a membrane complex involved in electron transport
F543_RS08210	COG1120	ATPase activity
F543_RS08215	COG0482	sulfurtransferase activity
F543_RS08230	COG1942	4-Oxalocrotonate Tautomerase
F543_RS08235	COG2991	Protein conserved in bacteria
F543_RS08240	COG1477	protein flavinylation
F543_RS08245	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F543_RS08250	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F543_RS08255	COG2871	sodium ion transport
F543_RS08260	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F543_RS08265	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F543_RS08270	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F543_RS08275	COG1805	sodium ion transport
F543_RS08285	COG0316	Belongs to the HesB IscA family
F543_RS08285	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F543_RS08290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F543_RS08295	COG0747	negative chemotaxis
F543_RS08300	COG0747	negative chemotaxis
F543_RS08305	COG0601	transmembrane transport
F543_RS08310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F543_RS08315	COG0444	Belongs to the ABC transporter superfamily
F543_RS08330	COG0471	metal ion transport
F543_RS08335	COG1169	isochorismate synthase
F543_RS08340	COG0436	Aminotransferase
F543_RS08370	COG3842	ATPase activity
F543_RS08375	COG0563	adenylate kinase activity
F543_RS08390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F543_RS08395	COG4605	iron ion homeostasis
F543_RS08400	COG4604	ABC transporter, ATP-binding protein
F543_RS08405	COG2814	Major facilitator Superfamily
F543_RS08415	COG1187	pseudouridine synthase activity
F543_RS08420	COG1605	Chorismate mutase
F543_RS08420	COG0077	Prephenate dehydratase
F543_RS08425	COG1216	Glycosyl transferase, family 2
F543_RS08430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F543_RS08440	COG0339	signal peptide processing
F543_RS08445	COG1012	belongs to the aldehyde dehydrogenase family
F543_RS08445	COG1454	alcohol dehydrogenase
F543_RS08450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F543_RS08460	COG1882	Formate acetyltransferase
F543_RS08465	COG2116	formate transmembrane transporter activity
F543_RS08470	COG0494	nUDIX hydrolase
F543_RS08480	COG1218	3'(2'),5'-bisphosphate nucleotidase
F543_RS08485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F543_RS08490	COG0363	glucosamine-6-phosphate deaminase activity
F543_RS08500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F543_RS08525	COG5413	integral membrane protein
F543_RS08540	COG4206	TonB-dependent receptor
F543_RS08560	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
F543_RS08580	COG0308	aminopeptidase N
F543_RS08590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F543_RS08600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F543_RS08605	COG0196	riboflavin kinase activity
F543_RS08640	COG0826	peptidase U32
F543_RS08650	COG0612	Peptidase, M16
F543_RS08655	COG4771	TonB-dependent receptor
F543_RS08685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F543_RS08690	COG0849	cell division
F543_RS08700	COG1181	Belongs to the D-alanine--D-alanine ligase family
F543_RS08710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F543_RS08715	COG0772	Belongs to the SEDS family
F543_RS08720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F543_RS08725	COG1943	Transposase
F543_RS08730	COG1397	ADP-ribosylglycohydrolase
F543_RS08735	COG1280	lysine exporter protein (LysE YggA)
F543_RS08745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F543_RS08750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F543_RS08755	COG0768	penicillin binding
F543_RS08760	COG3116	cell division
F543_RS08785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F543_RS08800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F543_RS08800	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F543_RS08805	COG1105	Belongs to the carbohydrate kinase PfkB family
F543_RS08810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F543_RS08810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F543_RS08810	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F543_RS08815	COG1794	racemase activity, acting on amino acids and derivatives
F543_RS08830	COG1640	4-alpha-glucanotransferase
F543_RS08835	COG0058	SHG alpha-glucan phosphorylase activity
F543_RS08845	COG0366	Alpha amylase catalytic
F543_RS08850	COG3833	ABC-type maltose transport systems, permease component
F543_RS08860	COG2182	Extracellular solute-binding protein
F543_RS08865	COG3842	ATPase activity
F543_RS08870	COG4580	involved in the transport of maltose and maltodextrins
F543_RS08880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F543_RS08885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F543_RS08890	COG1217	gtp-binding protein TYPA
F543_RS08895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F543_RS08900	COG0747	negative chemotaxis
F543_RS08905	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F543_RS08910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F543_RS08935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F543_RS08945	COG1652	LysM domain
F543_RS08955	COG0107	imidazoleglycerol-phosphate synthase activity
F543_RS08965	COG2852	Protein conserved in bacteria
F543_RS08975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F543_RS08985	COG0131	Imidazoleglycerol-phosphate dehydratase
F543_RS08985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F543_RS09030	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F543_RS09035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F543_RS09045	COG0537	adenosine 5'-monophosphoramidase activity
F543_RS09080	COG0330	HflC and HflK could
F543_RS09085	COG0330	HflC and HflK could
F543_RS09100	COG3301	Polysulphide reductase, NrfD
F543_RS09105	COG0437	4 iron, 4 sulfur cluster binding
F543_RS09110	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F543_RS09130	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F543_RS09135	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F543_RS09140	COG1178	ABC-type Fe3 transport system permease component
F543_RS09145	COG0569	domain protein
F543_RS09150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F543_RS09175	COG1739	Uncharacterized protein family UPF0029
F543_RS09200	COG1595	DNA-templated transcription, initiation
F543_RS09205	COG3219	Protein conserved in bacteria
F543_RS09220	COG2259	Doxx family
F543_RS09225	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F543_RS09230	COG0439	Biotin carboxylase
F543_RS09235	COG0511	ligase activity, forming carbon-carbon bonds
F543_RS09240	COG1840	ABC-type Fe3 transport system, periplasmic component
F543_RS09245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F543_RS09255	COG1253	flavin adenine dinucleotide binding
F543_RS09260	COG0686	Belongs to the AlaDH PNT family
F543_RS09265	COG0733	neurotransmitter:sodium symporter activity
F543_RS09280	COG1399	metal-binding, possibly nucleic acid-binding protein
F543_RS09295	COG0789	Transcriptional regulator
F543_RS09300	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F543_RS09365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F543_RS09395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F543_RS09400	COG0385	Bile acid
F543_RS09405	COG3719	Belongs to the RNase T2 family
F543_RS09415	COG2391	methyltransferase activity
F543_RS09420	COG0425	Belongs to the sulfur carrier protein TusA family
F543_RS09435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F543_RS09445	COG3030	protein affecting phage T7 exclusion by the F plasmid
F543_RS09470	COG2927	DNA polymerase III (CHI subunit)
F543_RS09475	COG2153	protein acetylation
F543_RS09490	COG0525	valine-tRNA ligase activity
F543_RS09510	COG1530	ribonuclease E activity
F543_RS09515	COG0668	transmembrane transport
F543_RS09520	COG1114	Component of the transport system for branched-chain amino acids
F543_RS09525	COG1028	Short-chain dehydrogenase reductase Sdr
F543_RS09530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F543_RS09535	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F543_RS09540	COG0142	geranyltranstransferase activity
F543_RS09545	COG4536	flavin adenine dinucleotide binding
F543_RS09550	COG4137	Cytochrome C assembly protein
F543_RS09565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F543_RS09630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F543_RS09640	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F543_RS09645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F543_RS09660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F543_RS09670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F543_RS09680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F543_RS09690	COG4783	chaperone-mediated protein folding
F543_RS09695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F543_RS09700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F543_RS09765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F543_RS09770	COG4558	Periplasmic binding protein
F543_RS09775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F543_RS09795	COG4206	TonB-dependent receptor
F543_RS09795	COG1629	transport
F543_RS09800	COG1053	succinate dehydrogenase
F543_RS09805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F543_RS09815	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F543_RS09835	COG3700	Belongs to the class B bacterial acid phosphatase family
F543_RS09840	COG1522	sequence-specific DNA binding
F543_RS09865	COG1755	Isoprenylcysteine carboxyl methyltransferase
F543_RS09875	COG2852	Protein conserved in bacteria
F543_RS09880	COG4545	Glutaredoxin-related protein
F543_RS09890	COG1268	BioY protein
F543_RS09900	COG2850	peptidyl-arginine hydroxylation
F543_RS09910	COG0084	hydrolase, TatD family'
F543_RS09915	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F543_RS09920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F543_RS09970	COG0471	metal ion transport
F543_RS09970	COG0490	domain, Protein
F543_RS09975	COG1858	cytochrome C peroxidase
F543_RS09980	COG1876	peptidase activity
F543_RS09985	COG0742	ribosomal rna small subunit methyltransferase
F543_RS09990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F543_RS09995	COG0594	ribonuclease P activity
F543_RS10000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F543_RS10030	COG3835	regulator
F543_RS10035	COG2610	gluconate transmembrane transporter activity
F543_RS10040	COG1929	Belongs to the glycerate kinase type-1 family
F543_RS10050	COG0737	Belongs to the 5'-nucleotidase family
F543_RS10055	COG0716	FMN binding
F543_RS10065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F543_RS10070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F543_RS10075	COG3084	Protein conserved in bacteria
F543_RS10085	COG3722	fumarate hydratase activity
F543_RS10095	COG2213	PTS system mannitol-specific
F543_RS10095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F543_RS10100	COG3085	chromosome segregation
F543_RS10135	COG0037	tRNA processing
F543_RS10140	COG1902	pentaerythritol trinitrate reductase activity
F543_RS10155	COG0728	peptidoglycan biosynthetic process
F543_RS10160	COG2116	formate transmembrane transporter activity
F543_RS10165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F543_RS10200	COG0470	DNA polymerase III
F543_RS10215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F543_RS10245	COG1561	YicC-like family, N-terminal region
F543_RS10250	COG0675	Transposase, IS605 OrfB family
F543_RS10255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F543_RS10255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F543_RS10260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F543_RS10265	COG0583	DNA-binding transcription factor activity
F543_RS10270	COG1309	transcriptional regulator
F543_RS10275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F543_RS10280	COG0095	Lipoate-protein ligase
F543_RS10285	COG2272	Belongs to the type-B carboxylesterase lipase family
F543_RS10295	COG1073	alpha beta
F543_RS10305	COG0656	L-ascorbic acid biosynthetic process
F543_RS10325	COG0673	inositol 2-dehydrogenase activity
F543_RS10330	COG1064	alcohol dehydrogenase
F543_RS10335	COG0778	Nitroreductase
F543_RS10340	COG1902	pentaerythritol trinitrate reductase activity
F543_RS10345	COG0583	DNA-binding transcription factor activity
F543_RS10350	COG2962	Rard protein
F543_RS10355	COG3070	regulator of competence-specific genes
F543_RS10395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F543_RS10405	COG0583	DNA-binding transcription factor activity
F543_RS10415	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F543_RS10445	COG1067	ATP-dependent peptidase activity
F543_RS10450	COG3120	sequence-specific DNA binding
F543_RS10455	COG2885	chlorophyll binding
F543_RS10455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F543_RS10465	COG0277	FAD linked oxidase domain protein
F543_RS10465	COG0247	lactate metabolic process
F543_RS10475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F543_RS10500	COG4771	TonB-dependent receptor
F543_RS10500	COG1629	transport
F543_RS10505	COG3721	Heme iron utilization protein
F543_RS10510	COG0748	coenzyme F420 binding
F543_RS10515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F543_RS10520	COG0606	chelatase, subunit chli
F543_RS10525	COG0443	Heat shock 70 kDa protein
F543_RS10530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F543_RS10550	COG0745	RESPONSE REGULATOR receiver
F543_RS10555	COG0295	cytidine deaminase activity
F543_RS10560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F543_RS10575	COG0076	glutamate decarboxylase activity
F543_RS10585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F543_RS10590	COG2050	protein possibly involved in aromatic compounds catabolism
F543_RS10595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F543_RS10605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F543_RS10620	COG0521	Mo-molybdopterin cofactor biosynthetic process
F543_RS10625	COG2832	Protein of unknown function (DUF454)
F543_RS10630	COG1215	transferase activity, transferring glycosyl groups
F543_RS10635	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F543_RS10650	COG0180	Tryptophanyl-tRNA synthetase
F543_RS10665	COG3265	gluconokinase activity
F543_RS10670	COG2610	gluconate transmembrane transporter activity
F543_RS10675	COG0561	phosphatase activity
F543_RS10685	COG3716	PTS system mannose fructose sorbose family IID component
F543_RS10690	COG3715	PTS system
F543_RS10695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F543_RS10695	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F543_RS10700	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F543_RS10725	COG3623	hexulose-6-phosphate isomerase
F543_RS10730	COG0235	Class ii aldolase
F543_RS10740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F543_RS10750	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F543_RS10765	COG3276	selenocysteine insertion sequence binding
F543_RS10770	COG2168	tRNA wobble position uridine thiolation
F543_RS10780	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F543_RS10785	COG2964	Protein conserved in bacteria
F543_RS10790	COG0545	Peptidyl-prolyl cis-trans isomerase
F543_RS10800	COG3111	PFAM Bacterial OB fold (BOF) protein
F543_RS10815	COG1846	Transcriptional regulator
F543_RS10825	COG1733	regulation of RNA biosynthetic process
F543_RS10830	COG2249	NAD(P)H dehydrogenase (quinone) activity
F543_RS10835	COG4589	Belongs to the CDS family
F543_RS10905	COG2814	Major facilitator Superfamily
F543_RS10910	COG2259	Doxx family
F543_RS10920	COG0789	Transcriptional regulator
F543_RS10930	COG0789	Transcriptional regulator
F543_RS10945	COG3759	membrane
F543_RS10980	COG3173	Aminoglycoside phosphotransferase
F543_RS10985	COG0488	(ABC) transporter
F543_RS11075	COG2826	transposase and inactivated derivatives, IS30 family
F543_RS11115	COG1309	transcriptional regulator
F543_RS11125	COG0583	DNA-binding transcription factor activity
F543_RS11155	COG1902	pentaerythritol trinitrate reductase activity
F543_RS11155	COG0446	pyridine nucleotide-disulphide oxidoreductase
F543_RS11170	COG3836	Belongs to the HpcH HpaI aldolase family
F543_RS11175	COG2249	NAD(P)H dehydrogenase (quinone) activity
F543_RS11180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F543_RS11185	COG1764	response to oxidative stress
F543_RS11220	COG2190	(PTS) system
F543_RS11220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F543_RS11220	COG1263	PTS System
F543_RS11225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F543_RS11230	COG1879	ABC-type sugar transport system periplasmic component
F543_RS11235	COG1172	Belongs to the binding-protein-dependent transport system permease family
F543_RS11255	COG1609	Transcriptional regulator
F543_RS11265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F543_RS11270	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F543_RS11270	COG0506	proline dehydrogenase activity
F543_RS11270	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F543_RS11285	COG1902	pentaerythritol trinitrate reductase activity
F543_RS11300	COG0583	DNA-binding transcription factor activity
F543_RS11345	COG3118	belongs to the thioredoxin family
F543_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
F543_RS11355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F543_RS11375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F543_RS11410	COG1752	Esterase of the alpha-beta hydrolase superfamily
F543_RS11415	COG1285	pathogenesis
F543_RS11420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F543_RS11425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F543_RS11445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F543_RS11455	COG0356	it plays a direct role in the translocation of protons across the membrane
F543_RS11470	COG1178	ABC-type Fe3 transport system permease component
F543_RS11475	COG3842	ATPase activity
F543_RS11490	COG0357	Ribosomal RNA small subunit methyltransferase G
F543_RS11500	COG0445	tRNA wobble uridine modification
F543_RS11535	COG3210	domain, Protein
F543_RS11605	COG3210	domain, Protein