locus-tag	class	description
F544_RS00010	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F544_RS00015	COG0799	negative regulation of ribosome biogenesis
F544_RS00025	COG2264	protein methyltransferase activity
F544_RS00030	COG0445	tRNA wobble uridine modification
F544_RS00045	COG0357	Ribosomal RNA small subunit methyltransferase G
F544_RS00060	COG3842	ATPase activity
F544_RS00065	COG1178	ABC-type Fe3 transport system permease component
F544_RS00080	COG0356	it plays a direct role in the translocation of protons across the membrane
F544_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F544_RS00110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F544_RS00115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F544_RS00120	COG1285	pathogenesis
F544_RS00125	COG1752	Esterase of the alpha-beta hydrolase superfamily
F544_RS00150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F544_RS00170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F544_RS00175	COG1028	Short-chain dehydrogenase reductase Sdr
F544_RS00180	COG3118	belongs to the thioredoxin family
F544_RS00230	COG0583	DNA-binding transcription factor activity
F544_RS00240	COG1902	pentaerythritol trinitrate reductase activity
F544_RS00255	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F544_RS00255	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F544_RS00255	COG0506	proline dehydrogenase activity
F544_RS00260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F544_RS00270	COG1609	Transcriptional regulator
F544_RS00290	COG1172	Belongs to the binding-protein-dependent transport system permease family
F544_RS00295	COG1879	ABC-type sugar transport system periplasmic component
F544_RS00300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F544_RS00305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F544_RS00305	COG1263	PTS System
F544_RS00305	COG2190	(PTS) system
F544_RS00340	COG1764	response to oxidative stress
F544_RS00345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F544_RS00350	COG2249	NAD(P)H dehydrogenase (quinone) activity
F544_RS00355	COG3836	Belongs to the HpcH HpaI aldolase family
F544_RS00370	COG1902	pentaerythritol trinitrate reductase activity
F544_RS00395	COG0583	DNA-binding transcription factor activity
F544_RS00400	COG2259	Doxx family
F544_RS00405	COG2814	Major facilitator Superfamily
F544_RS00465	COG2249	NAD(P)H dehydrogenase (quinone) activity
F544_RS00470	COG1733	regulation of RNA biosynthetic process
F544_RS00480	COG1846	Transcriptional regulator
F544_RS00495	COG3111	PFAM Bacterial OB fold (BOF) protein
F544_RS00500	COG2900	Belongs to the SlyX family
F544_RS00505	COG0545	Peptidyl-prolyl cis-trans isomerase
F544_RS00510	COG2964	Protein conserved in bacteria
F544_RS00515	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F544_RS00525	COG2168	tRNA wobble position uridine thiolation
F544_RS00530	COG3276	selenocysteine insertion sequence binding
F544_RS00545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F544_RS00555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F544_RS00565	COG0235	Class ii aldolase
F544_RS00570	COG3623	hexulose-6-phosphate isomerase
F544_RS00595	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F544_RS00600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F544_RS00600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F544_RS00605	COG3715	PTS system
F544_RS00610	COG3716	PTS system mannose fructose sorbose family IID component
F544_RS00620	COG0561	phosphatase activity
F544_RS00625	COG2610	gluconate transmembrane transporter activity
F544_RS00630	COG3265	gluconokinase activity
F544_RS00645	COG0180	Tryptophanyl-tRNA synthetase
F544_RS00660	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F544_RS00665	COG1215	transferase activity, transferring glycosyl groups
F544_RS00670	COG2832	Protein of unknown function (DUF454)
F544_RS00675	COG0521	Mo-molybdopterin cofactor biosynthetic process
F544_RS00690	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F544_RS00700	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F544_RS00705	COG2050	protein possibly involved in aromatic compounds catabolism
F544_RS00710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F544_RS00720	COG0076	glutamate decarboxylase activity
F544_RS00735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F544_RS00740	COG0295	cytidine deaminase activity
F544_RS00745	COG0745	RESPONSE REGULATOR receiver
F544_RS00760	COG0443	Heat shock 70 kDa protein
F544_RS00770	COG0606	chelatase, subunit chli
F544_RS00775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F544_RS00780	COG0748	coenzyme F420 binding
F544_RS00785	COG3721	Heme iron utilization protein
F544_RS00790	COG4771	TonB-dependent receptor
F544_RS00790	COG1629	transport
F544_RS00795	COG0675	Transposase, IS605 OrfB family
F544_RS00820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F544_RS00830	COG0277	FAD linked oxidase domain protein
F544_RS00830	COG0247	lactate metabolic process
F544_RS00840	COG2885	chlorophyll binding
F544_RS00840	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F544_RS00845	COG3120	sequence-specific DNA binding
F544_RS00850	COG1067	ATP-dependent peptidase activity
F544_RS00880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F544_RS00890	COG0583	DNA-binding transcription factor activity
F544_RS00900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F544_RS00940	COG3070	regulator of competence-specific genes
F544_RS00945	COG2962	Rard protein
F544_RS00950	COG0583	DNA-binding transcription factor activity
F544_RS00955	COG1902	pentaerythritol trinitrate reductase activity
F544_RS00960	COG0778	Nitroreductase
F544_RS00965	COG1064	alcohol dehydrogenase
F544_RS00970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F544_RS00975	COG0673	inositol 2-dehydrogenase activity
F544_RS00980	COG0095	Lipoate-protein ligase
F544_RS00985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F544_RS00990	COG1309	transcriptional regulator
F544_RS00995	COG0583	DNA-binding transcription factor activity
F544_RS01000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F544_RS01005	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F544_RS01005	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F544_RS01010	COG1561	YicC-like family, N-terminal region
F544_RS01040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F544_RS01055	COG0470	DNA polymerase III
F544_RS01090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F544_RS01095	COG2116	formate transmembrane transporter activity
F544_RS01100	COG0728	peptidoglycan biosynthetic process
F544_RS01115	COG1902	pentaerythritol trinitrate reductase activity
F544_RS01120	COG0675	Transposase, IS605 OrfB family
F544_RS01125	COG0037	tRNA processing
F544_RS01130	COG1490	D-aminoacyl-tRNA deacylase activity
F544_RS01165	COG0305	Participates in initiation and elongation during chromosome replication
F544_RS01195	COG0629	single-stranded DNA binding
F544_RS01240	COG2132	Multicopper oxidase
F544_RS01255	COG0667	Aldo Keto reductase
F544_RS01275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F544_RS01585	COG0511	ligase activity, forming carbon-carbon bonds
F544_RS01600	COG2826	transposase and inactivated derivatives, IS30 family
F544_RS01625	COG3085	chromosome segregation
F544_RS01630	COG2213	PTS system mannitol-specific
F544_RS01630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F544_RS01640	COG3722	fumarate hydratase activity
F544_RS01650	COG3084	Protein conserved in bacteria
F544_RS01655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F544_RS01660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F544_RS01670	COG0716	FMN binding
F544_RS01675	COG0737	Belongs to the 5'-nucleotidase family
F544_RS01695	COG1929	Belongs to the glycerate kinase type-1 family
F544_RS01700	COG2610	gluconate transmembrane transporter activity
F544_RS01705	COG3835	regulator
F544_RS01735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F544_RS01740	COG0594	ribonuclease P activity
F544_RS01745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F544_RS01750	COG0742	ribosomal rna small subunit methyltransferase
F544_RS01755	COG1876	peptidase activity
F544_RS01760	COG1858	cytochrome C peroxidase
F544_RS01765	COG0490	domain, Protein
F544_RS01765	COG0471	metal ion transport
F544_RS01810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F544_RS01815	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F544_RS01820	COG0084	hydrolase, TatD family'
F544_RS01830	COG2850	peptidyl-arginine hydroxylation
F544_RS01840	COG1268	BioY protein
F544_RS01850	COG4545	Glutaredoxin-related protein
F544_RS01855	COG2852	Protein conserved in bacteria
F544_RS01865	COG1755	Isoprenylcysteine carboxyl methyltransferase
F544_RS01890	COG1522	sequence-specific DNA binding
F544_RS01895	COG3700	Belongs to the class B bacterial acid phosphatase family
F544_RS01915	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F544_RS01925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F544_RS01930	COG1053	succinate dehydrogenase
F544_RS01935	COG1629	transport
F544_RS01935	COG4206	TonB-dependent receptor
F544_RS01950	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F544_RS01955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F544_RS01960	COG4558	Periplasmic binding protein
F544_RS01965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F544_RS01985	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F544_RS02030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F544_RS02035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F544_RS02040	COG4783	chaperone-mediated protein folding
F544_RS02050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F544_RS02055	COG1858	cytochrome C peroxidase
F544_RS02060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F544_RS02070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F544_RS02085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F544_RS02090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F544_RS02100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F544_RS02165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F544_RS02180	COG4137	Cytochrome C assembly protein
F544_RS02185	COG4536	flavin adenine dinucleotide binding
F544_RS02190	COG0142	geranyltranstransferase activity
F544_RS02195	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F544_RS02200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F544_RS02205	COG1028	Short-chain dehydrogenase reductase Sdr
F544_RS02210	COG1114	Component of the transport system for branched-chain amino acids
F544_RS02215	COG0668	transmembrane transport
F544_RS02220	COG1530	ribonuclease E activity
F544_RS02260	COG2153	protein acetylation
F544_RS02265	COG2927	DNA polymerase III (CHI subunit)
F544_RS02290	COG3030	protein affecting phage T7 exclusion by the F plasmid
F544_RS02295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F544_RS02310	COG0425	Belongs to the sulfur carrier protein TusA family
F544_RS02315	COG2391	methyltransferase activity
F544_RS02325	COG3719	Belongs to the RNase T2 family
F544_RS02330	COG0385	Bile acid
F544_RS02335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F544_RS02370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F544_RS02375	COG1063	alcohol dehydrogenase
F544_RS02405	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F544_RS02410	COG0789	Transcriptional regulator
F544_RS02415	COG0416	fatty acid biosynthetic process
F544_RS02425	COG1399	metal-binding, possibly nucleic acid-binding protein
F544_RS02440	COG0733	neurotransmitter:sodium symporter activity
F544_RS02445	COG0686	Belongs to the AlaDH PNT family
F544_RS02450	COG1253	flavin adenine dinucleotide binding
F544_RS02460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F544_RS02465	COG1840	ABC-type Fe3 transport system, periplasmic component
F544_RS02470	COG0511	ligase activity, forming carbon-carbon bonds
F544_RS02475	COG0439	Biotin carboxylase
F544_RS02480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F544_RS02485	COG2259	Doxx family
F544_RS02500	COG3219	Protein conserved in bacteria
F544_RS02505	COG1595	DNA-templated transcription, initiation
F544_RS02530	COG1739	Uncharacterized protein family UPF0029
F544_RS02555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F544_RS02560	COG0569	domain protein
F544_RS02565	COG1178	ABC-type Fe3 transport system permease component
F544_RS02570	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F544_RS02575	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F544_RS02595	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F544_RS02600	COG0437	4 iron, 4 sulfur cluster binding
F544_RS02605	COG3301	Polysulphide reductase, NrfD
F544_RS02620	COG0330	HflC and HflK could
F544_RS02625	COG0330	HflC and HflK could
F544_RS02660	COG0537	adenosine 5'-monophosphoramidase activity
F544_RS02670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F544_RS02675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F544_RS02720	COG0131	Imidazoleglycerol-phosphate dehydratase
F544_RS02720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F544_RS02730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F544_RS02745	COG0107	imidazoleglycerol-phosphate synthase activity
F544_RS02755	COG1652	LysM domain
F544_RS02765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F544_RS02780	COG1045	serine acetyltransferase
F544_RS02785	COG0557	exoribonuclease II activity
F544_RS02790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F544_RS02795	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F544_RS02800	COG0747	negative chemotaxis
F544_RS02805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F544_RS02810	COG1217	gtp-binding protein TYPA
F544_RS02815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F544_RS02820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F544_RS02830	COG4580	involved in the transport of maltose and maltodextrins
F544_RS02835	COG3842	ATPase activity
F544_RS02850	COG3833	ABC-type maltose transport systems, permease component
F544_RS02855	COG0366	Alpha amylase catalytic
F544_RS02860	COG2909	trisaccharide binding
F544_RS02865	COG0058	SHG alpha-glucan phosphorylase activity
F544_RS02875	COG1640	4-alpha-glucanotransferase
F544_RS02890	COG1794	racemase activity, acting on amino acids and derivatives
F544_RS02895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F544_RS02895	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F544_RS02895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F544_RS02900	COG1105	Belongs to the carbohydrate kinase PfkB family
F544_RS02905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F544_RS02905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F544_RS02920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F544_RS02945	COG3116	cell division
F544_RS02950	COG0768	penicillin binding
F544_RS02955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F544_RS02960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F544_RS02970	COG1397	ADP-ribosylglycohydrolase
F544_RS02980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F544_RS02985	COG0772	Belongs to the SEDS family
F544_RS03010	COG0849	cell division
F544_RS03015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F544_RS03045	COG4771	TonB-dependent receptor
F544_RS03050	COG0612	Peptidase, M16
F544_RS03055	COG4178	(ABC) transporter
F544_RS03060	COG0826	peptidase U32
F544_RS03095	COG0196	riboflavin kinase activity
F544_RS03100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F544_RS03105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F544_RS03110	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F544_RS03120	COG0308	aminopeptidase N
F544_RS03140	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
F544_RS03175	COG5413	integral membrane protein
F544_RS03200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F544_RS03210	COG0363	glucosamine-6-phosphate deaminase activity
F544_RS03215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F544_RS03220	COG1218	3'(2'),5'-bisphosphate nucleotidase
F544_RS03230	COG0494	nUDIX hydrolase
F544_RS03235	COG2116	formate transmembrane transporter activity
F544_RS03240	COG1882	Formate acetyltransferase
F544_RS03250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F544_RS03255	COG1454	alcohol dehydrogenase
F544_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
F544_RS03260	COG0339	signal peptide processing
F544_RS03270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F544_RS03275	COG1216	Glycosyl transferase, family 2
F544_RS03280	COG1605	Chorismate mutase
F544_RS03280	COG0077	Prephenate dehydratase
F544_RS03285	COG1187	pseudouridine synthase activity
F544_RS03295	COG2814	Major facilitator Superfamily
F544_RS03300	COG4604	ABC transporter, ATP-binding protein
F544_RS03305	COG4605	iron ion homeostasis
F544_RS03310	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F544_RS03315	COG4607	ABC-type enterochelin transport system periplasmic component
F544_RS03325	COG0563	adenylate kinase activity
F544_RS03330	COG3842	ATPase activity
F544_RS03340	COG1840	ABC-type Fe3 transport system, periplasmic component
F544_RS03345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F544_RS03360	COG0436	Aminotransferase
F544_RS03365	COG1169	isochorismate synthase
F544_RS03370	COG0471	metal ion transport
F544_RS03375	COG4608	Belongs to the ABC transporter superfamily
F544_RS03385	COG0444	Belongs to the ABC transporter superfamily
F544_RS03390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F544_RS03395	COG0601	transmembrane transport
F544_RS03400	COG0747	negative chemotaxis
F544_RS03405	COG0747	negative chemotaxis
F544_RS03410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F544_RS03415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F544_RS03415	COG0316	Belongs to the HesB IscA family
F544_RS03425	COG1805	sodium ion transport
F544_RS03430	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F544_RS03435	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F544_RS03440	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F544_RS03445	COG2871	sodium ion transport
F544_RS03450	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F544_RS03455	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F544_RS03460	COG1477	protein flavinylation
F544_RS03465	COG2991	Protein conserved in bacteria
F544_RS03470	COG1942	4-Oxalocrotonate Tautomerase
F544_RS03480	COG0482	sulfurtransferase activity
F544_RS03485	COG1120	ATPase activity
F544_RS03500	COG4657	Part of a membrane complex involved in electron transport
F544_RS03515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F544_RS03540	COG1560	Kdo2-lipid A biosynthetic process
F544_RS03545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F544_RS03550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F544_RS03555	COG0564	pseudouridine synthase activity
F544_RS03560	COG1090	epimerase
F544_RS03580	COG3118	belongs to the thioredoxin family
F544_RS03585	COG0492	ferredoxin-NADP+ reductase activity
F544_RS03590	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F544_RS03595	COG0793	Belongs to the peptidase S41A family
F544_RS03600	COG2989	Protein conserved in bacteria
F544_RS03605	COG3108	Peptidase M15
F544_RS03610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F544_RS03615	COG2853	Lipoprotein
F544_RS03625	COG3101	peptidyl-lysine hydroxylation
F544_RS03630	COG0778	Nitroreductase
F544_RS03635	COG0616	signal peptide processing
F544_RS03640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F544_RS03650	COG1694	Mazg nucleotide pyrophosphohydrolase
F544_RS03655	COG3739	integral membrane protein
F544_RS03665	COG1215	transferase activity, transferring glycosyl groups
F544_RS03670	COG1649	PFAM Uncharacterised BCR, COG1649
F544_RS03670	COG0726	polysaccharide deacetylase
F544_RS03680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F544_RS03690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F544_RS03695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F544_RS03705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F544_RS03710	COG0210	DNA helicase
F544_RS03740	COG1328	CTP reductase activity
F544_RS03745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F544_RS03750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F544_RS03760	COG0811	peptide transport
F544_RS03770	COG0616	signal peptide processing
F544_RS03775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F544_RS03795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F544_RS03810	COG2255	four-way junction helicase activity
F544_RS03820	COG1177	transmembrane transport
F544_RS03825	COG1176	ABC-type spermidine putrescine transport system, permease component I
F544_RS03830	COG3842	ATPase activity
F544_RS03835	COG4771	TonB-dependent receptor
F544_RS03835	COG1629	transport
F544_RS03845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F544_RS03850	COG0346	lactoylglutathione lyase activity
F544_RS03860	COG2911	Protein conserved in bacteria
F544_RS03875	COG0488	(ABC) transporter
F544_RS03880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F544_RS03900	COG0456	acetyltransferase
F544_RS03905	COG0513	Belongs to the DEAD box helicase family
F544_RS03910	COG1216	Glycosyl transferase, family 2
F544_RS03920	COG0012	GTP binding
F544_RS03930	COG4172	Belongs to the ABC transporter superfamily
F544_RS03935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F544_RS03940	COG0601	transmembrane transport
F544_RS03945	COG0747	negative chemotaxis
F544_RS03960	COG1426	Protein conserved in bacteria
F544_RS03965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F544_RS03975	COG2976	Protein conserved in bacteria
F544_RS03980	COG3201	nicotinamide mononucleotide transporter
F544_RS03985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F544_RS03990	COG4133	protoheme IX ABC transporter activity
F544_RS03995	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F544_RS04000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F544_RS04005	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F544_RS04010	COG0471	metal ion transport
F544_RS04015	COG0126	phosphoglycerate kinase activity
F544_RS04020	COG0191	fructose-bisphosphate aldolase activity
F544_RS04025	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
F544_RS04030	COG4172	Belongs to the ABC transporter superfamily
F544_RS04035	COG0778	Nitroreductase
F544_RS04045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F544_RS04050	COG0602	queuosine metabolic process
F544_RS04055	COG0720	synthase
F544_RS04060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F544_RS04065	COG3730	PTS system glucitol sorbitol-specific
F544_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
F544_RS04085	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
F544_RS04090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F544_RS04095	COG1349	DNA-binding transcription factor activity
F544_RS04100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F544_RS04110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F544_RS04155	COG1518	maintenance of DNA repeat elements
F544_RS04205	COG2195	Cleaves the N-terminal amino acid of tripeptides
F544_RS04210	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F544_RS04215	COG0194	GDP metabolic process
F544_RS04220	COG1538	Outer membrane efflux protein
F544_RS04225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F544_RS04225	COG0301	tRNA thio-modification
F544_RS04235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F544_RS04240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F544_RS04245	COG1525	nuclease
F544_RS04250	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F544_RS04255	COG2391	methyltransferase activity
F544_RS04260	COG0425	Belongs to the sulfur carrier protein TusA family
F544_RS04275	COG2965	DNA replication, synthesis of RNA primer
F544_RS04290	COG2841	Protein conserved in bacteria
F544_RS04295	COG2268	Band 7 protein
F544_RS04300	COG1609	Transcriptional regulator
F544_RS04315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F544_RS04320	COG0697	spore germination
F544_RS04325	COG2081	HI0933 family
F544_RS04330	COG0497	DNA recombination
F544_RS04350	COG1115	amino acid carrier protein
F544_RS04355	COG0181	hydroxymethylbilane synthase activity
F544_RS04365	COG2959	enzyme of heme biosynthesis
F544_RS04370	COG3071	HemY protein
F544_RS04375	COG1271	oxidase subunit
F544_RS04380	COG1294	oxidase, subunit
F544_RS04390	COG0824	Thioesterase
F544_RS04395	COG0811	peptide transport
F544_RS04400	COG0848	biopolymer transport protein
F544_RS04405	COG3064	Membrane
F544_RS04405	COG3064	Membrane
F544_RS04410	COG0823	Involved in the tonB-independent uptake of proteins
F544_RS04420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F544_RS04425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F544_RS04435	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F544_RS04450	COG1704	LemA family
F544_RS04470	COG0583	DNA-binding transcription factor activity
F544_RS04475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F544_RS04480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F544_RS04485	COG2031	fatty acid transporter
F544_RS04490	COG0183	Belongs to the thiolase family
F544_RS04495	COG1028	Short-chain dehydrogenase reductase Sdr
F544_RS04515	COG3106	COG3106 Predicted ATPase
F544_RS04520	COG3025	triphosphatase activity
F544_RS04530	COG0564	pseudouridine synthase activity
F544_RS04535	COG3098	single-species biofilm formation
F544_RS04540	COG0135	phosphoribosylanthranilate isomerase activity
F544_RS04540	COG0134	indole-3-glycerol-phosphate synthase activity
F544_RS04550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F544_RS04555	COG0303	'Molybdopterin
F544_RS04560	COG2095	MarC family integral membrane protein
F544_RS04565	COG0488	(ABC) transporter
F544_RS04570	COG2610	gluconate transmembrane transporter activity
F544_RS04590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F544_RS04595	COG0330	HflC and HflK could
F544_RS04605	COG1643	Atp-dependent helicase
F544_RS04630	COG2066	Belongs to the glutaminase family
F544_RS04635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F544_RS04640	COG1560	Kdo2-lipid A biosynthetic process
F544_RS04645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F544_RS04650	COG0393	Putative heavy-metal-binding
F544_RS04655	COG2983	Belongs to the UPF0260 family
F544_RS04660	COG4221	oxidoreductase activity
F544_RS04675	COG2814	Major facilitator Superfamily
F544_RS04680	COG1187	pseudouridine synthase activity
F544_RS04685	COG2095	MarC family integral membrane protein
F544_RS04690	COG4166	transmembrane transport
F544_RS04695	COG0489	protein tyrosine kinase activity
F544_RS04705	COG0159	tryptophan synthase activity
F544_RS04710	COG2005	Transcriptional regulator
F544_RS04740	COG0725	ABC transporter, periplasmic molybdate-binding protein
F544_RS04745	COG4149	molybdate abc transporter
F544_RS04750	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F544_RS04765	COG3683	transport system, periplasmic component
F544_RS04770	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F544_RS04775	COG1115	amino acid carrier protein
F544_RS04785	COG0681	Belongs to the peptidase S26 family
F544_RS04805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F544_RS04810	COG2949	membrane
F544_RS04820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F544_RS04825	COG1137	ATPase activity
F544_RS04830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F544_RS04835	COG1660	Displays ATPase and GTPase activities
F544_RS04840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F544_RS04850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F544_RS04855	COG0237	dephospho-CoA kinase activity
F544_RS04865	COG1459	type II secretion system
F544_RS04870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F544_RS04875	COG4969	Belongs to the N-Me-Phe pilin family
F544_RS04880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F544_RS04885	COG1757	Na H antiporter
F544_RS04895	COG0328	RNA-DNA hybrid ribonuclease activity
F544_RS04900	COG0747	negative chemotaxis
F544_RS04910	COG0444	Belongs to the ABC transporter superfamily
F544_RS04915	COG4608	Belongs to the ABC transporter superfamily
F544_RS04920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F544_RS04925	COG1286	toxin biosynthetic process
F544_RS04930	COG3210	domain, Protein
F544_RS04960	COG0183	Belongs to the thiolase family
F544_RS04975	COG0037	tRNA processing
F544_RS04980	COG2056	Na+-H+ antiporter family
F544_RS04985	COG0708	Exodeoxyribonuclease III
F544_RS04990	COG2731	YhcH YjgK YiaL family protein
F544_RS04995	COG1737	Transcriptional regulator
F544_RS05020	COG1944	ATP diphosphatase activity
F544_RS05025	COG1328	CTP reductase activity
F544_RS05025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F544_RS05030	COG0602	queuosine metabolic process
F544_RS05035	COG1530	ribonuclease E activity
F544_RS05040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F544_RS05045	COG4991	sh3 domain protein
F544_RS05050	COG0306	phosphate transporter
F544_RS05055	COG1392	Phosphate transport regulator
F544_RS05075	COG0791	NLP P60 protein
F544_RS05080	COG3083	sulfuric ester hydrolase activity
F544_RS05090	COG0288	reversible hydration of carbon dioxide
F544_RS05095	COG1278	Cold shock
F544_RS05115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F544_RS05130	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F544_RS05145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F544_RS05160	COG2925	Exonuclease
F544_RS05165	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
F544_RS05175	COG0613	PHP domain protein
F544_RS05180	COG0285	dihydrofolate synthase activity
F544_RS05185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F544_RS05190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F544_RS05195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F544_RS05200	COG0314	molybdopterin synthase activity
F544_RS05205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F544_RS05210	COG1444	tRNA N-acetyltransferase activity
F544_RS05215	COG1879	ABC-type sugar transport system periplasmic component
F544_RS05220	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F544_RS05225	COG0121	glutamine amidotransferase
F544_RS05230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F544_RS05235	COG1121	(ABC) transporter
F544_RS05240	COG0739	heme binding
F544_RS05245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F544_RS05250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F544_RS05260	COG0561	phosphatase activity
F544_RS05265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F544_RS05290	COG3945	hemerythrin HHE cation binding domain
F544_RS05295	COG0425	Belongs to the sulfur carrier protein TusA family
F544_RS05310	COG2358	TRAP transporter, solute receptor (TAXI family
F544_RS05325	COG5645	(Lipo)protein
F544_RS05335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F544_RS05340	COG0556	nucleotide-excision repair
F544_RS05355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F544_RS05360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F544_RS05365	COG3209	COG3209 Rhs family protein
F544_RS05375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F544_RS05380	COG0629	single-stranded DNA binding
F544_RS05385	COG3105	Protein conserved in bacteria
F544_RS05395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F544_RS05405	COG4942	peptidase
F544_RS05410	COG0729	surface antigen
F544_RS05415	COG2911	Protein conserved in bacteria
F544_RS05420	COG4988	ABC transporter
F544_RS05425	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F544_RS05430	COG2864	formate dehydrogenase
F544_RS05435	COG0437	4 iron, 4 sulfur cluster binding
F544_RS05440	COG3383	formate dehydrogenase (NAD+) activity
F544_RS05440	COG0243	molybdopterin cofactor binding
F544_RS05445	COG3383	formate dehydrogenase (NAD+) activity
F544_RS05445	COG0243	molybdopterin cofactor binding
F544_RS05470	COG0477	Major facilitator Superfamily
F544_RS05480	COG0351	phosphomethylpyrimidine kinase
F544_RS05490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F544_RS05495	COG1116	anion transmembrane transporter activity
F544_RS05505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F544_RS05510	COG2951	lytic endotransglycosylase activity
F544_RS05520	COG0625	glutathione transferase activity
F544_RS05525	COG2969	positive regulation of protein catabolic process
F544_RS05535	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F544_RS05545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F544_RS05550	COG1917	Cupin 2, conserved barrel domain protein
F544_RS05550	COG4977	sequence-specific DNA binding
F544_RS05565	COG3302	dmso reductase anchor subunit
F544_RS05570	COG0437	4 iron, 4 sulfur cluster binding
F544_RS05575	COG0243	molybdopterin cofactor binding
F544_RS05585	COG3381	protein complex oligomerization
F544_RS05595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F544_RS05615	COG4783	chaperone-mediated protein folding
F544_RS05635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F544_RS05645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F544_RS05650	COG0814	amino acid
F544_RS05655	COG1522	sequence-specific DNA binding
F544_RS05660	COG1674	ftsk spoiiie
F544_RS05665	COG2321	neutral zinc metallopeptidase
F544_RS05670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F544_RS05675	COG1214	PFAM Peptidase M22, glycoprotease
F544_RS05680	COG0527	aspartate kinase activity
F544_RS05685	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
F544_RS05695	COG0006	proline dipeptidase activity
F544_RS05700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F544_RS05715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F544_RS05725	COG0151	Belongs to the GarS family
F544_RS05730	COG0138	bifunctional purine biosynthesis protein purh
F544_RS05735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F544_RS05760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F544_RS05765	COG0277	FAD linked oxidase domain protein
F544_RS05770	COG0857	belongs to the CobB CobQ family
F544_RS05770	COG0280	phosphate acetyltransferase
F544_RS05780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F544_RS05785	COG1940	carbohydrate kinase activity
F544_RS05785	COG1846	Transcriptional regulator
F544_RS05790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F544_RS05795	COG0023	Translation Initiation Factor
F544_RS05805	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F544_RS05810	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F544_RS05820	COG0539	negative regulation of cytoplasmic translation
F544_RS05830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F544_RS05835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F544_RS05840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F544_RS05850	COG0589	response to stress
F544_RS05855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F544_RS05860	COG0508	dehydrogenase complex catalyzes the overall conversion of
F544_RS05865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F544_RS05880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F544_RS05910	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F544_RS05910	COG3264	Mechanosensitive ion channel
F544_RS05915	COG0318	PFAM AMP-dependent synthetase and ligase
F544_RS05925	COG0596	Alpha beta hydrolase
F544_RS05940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F544_RS05945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F544_RS05950	COG1309	transcriptional regulator
F544_RS05955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F544_RS05960	COG0730	response to heat
F544_RS05965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F544_RS05970	COG0243	molybdopterin cofactor binding
F544_RS05985	COG3005	denitrification pathway
F544_RS06000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F544_RS06005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F544_RS06010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F544_RS06020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F544_RS06025	COG1349	DNA-binding transcription factor activity
F544_RS06045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F544_RS06050	COG4172	Belongs to the ABC transporter superfamily
F544_RS06055	COG4171	peptide transport system, permease
F544_RS06060	COG4168	peptide transport system, permease
F544_RS06065	COG4166	transmembrane transport
F544_RS06070	COG3283	Transcriptional regulator of aromatic amino acids metabolism
F544_RS06110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F544_RS06115	COG0741	lytic transglycosylase activity
F544_RS06120	COG0814	amino acid
F544_RS06165	COG3210	domain, Protein
F544_RS06175	COG0281	malic enzyme
F544_RS06175	COG0280	phosphate acetyltransferase
F544_RS06180	COG0028	Belongs to the TPP enzyme family
F544_RS06185	COG0440	acetolactate synthase activity
F544_RS06200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F544_RS06205	COG0737	Belongs to the 5'-nucleotidase family
F544_RS06210	COG0842	Transport permease protein
F544_RS06215	COG1131	(ABC) transporter
F544_RS06220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F544_RS06230	COG2814	Major facilitator Superfamily
F544_RS06235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F544_RS06245	COG0617	tRNA 3'-terminal CCA addition
F544_RS06250	COG0542	response to heat
F544_RS06275	COG0195	Participates in both transcription termination and antitermination
F544_RS06290	COG1494	fructose-1,6-bisphosphatase
F544_RS06310	COG2822	iron ion transport
F544_RS06315	COG2837	iron assimilation
F544_RS06320	COG0672	)-iron permease
F544_RS06325	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F544_RS06330	COG1523	belongs to the glycosyl hydrolase 13 family
F544_RS06335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F544_RS06345	COG0517	IMP dehydrogenase activity
F544_RS06345	COG0516	GMP reductase activity
F544_RS06360	COG3047	cAMP biosynthetic process
F544_RS06370	COG0564	pseudouridine synthase activity
F544_RS06395	COG0513	Belongs to the DEAD box helicase family
F544_RS06405	COG0433	COG0433 Predicted ATPase
F544_RS06415	COG1448	Aminotransferase
F544_RS06420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F544_RS06420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F544_RS06425	COG0658	competence protein
F544_RS06425	COG2333	competence protein COMEC
F544_RS06435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F544_RS06440	COG0737	Belongs to the 5'-nucleotidase family
F544_RS06455	COG0312	modulator of DNA gyrase
F544_RS06465	COG3094	Invasion gene expression up-regulator, SirB
F544_RS06470	COG2226	methyltransferase
F544_RS06475	COG0626	cystathionine gamma-synthase activity
F544_RS06490	COG2363	Small membrane protein
F544_RS06495	COG3074	FtsZ-dependent cytokinesis
F544_RS06510	COG0058	SHG alpha-glucan phosphorylase activity
F544_RS06515	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F544_RS06520	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
F544_RS06540	COG0248	Ppx GppA phosphatase
F544_RS06545	COG3956	TIGRFAM MazG family protein
F544_RS06550	COG0745	RESPONSE REGULATOR receiver
F544_RS06555	COG2205	protein histidine kinase activity
F544_RS06560	COG1136	(ABC) transporter
F544_RS06560	COG0577	efflux transmembrane transporter activity
F544_RS06565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F544_RS06570	COG0372	Belongs to the citrate synthase family
F544_RS06580	COG0538	isocitrate dehydrogenase activity
F544_RS06585	COG0471	metal ion transport
F544_RS06590	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F544_RS06590	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
F544_RS06595	COG3051	citrate lyase alpha subunit
F544_RS06600	COG2301	Belongs to the HpcH HpaI aldolase family
F544_RS06605	COG3052	prosthetic group binding
F544_RS06610	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F544_RS06615	COG0840	transmembrane signaling receptor activity
F544_RS06620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F544_RS06625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F544_RS06630	COG3036	rescue of stalled ribosome
F544_RS06635	COG2226	methyltransferase
F544_RS06655	COG0243	molybdopterin cofactor binding
F544_RS06660	COG1556	Lactate utilization protein
F544_RS06665	COG1139	Iron-sulfur cluster binding protein
F544_RS06670	COG0247	lactate metabolic process
F544_RS06675	COG1620	l-lactate permease
F544_RS06680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F544_RS06690	COG0305	Participates in initiation and elongation during chromosome replication
F544_RS06715	COG0859	PFAM glycosyl transferase family 9
F544_RS06730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F544_RS06730	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F544_RS06735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F544_RS06740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F544_RS06745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F544_RS06750	COG1760	l-serine dehydratase
F544_RS06755	COG0814	amino acid
F544_RS06760	COG0567	Dehydrogenase, E1 component
F544_RS06765	COG0508	dehydrogenase complex catalyzes the overall conversion of
F544_RS06785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F544_RS06790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F544_RS06795	COG0590	tRNA wobble adenosine to inosine editing
F544_RS06800	COG0513	Belongs to the DEAD box helicase family
F544_RS06805	COG4785	May be involved in cell division
F544_RS06815	COG0784	Response regulator, receiver
F544_RS06815	COG2198	Histidine kinase
F544_RS06815	COG5002	protein histidine kinase activity
F544_RS06820	COG0697	spore germination
F544_RS06825	COG2840	Smr protein MutS2
F544_RS06835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F544_RS06840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F544_RS06840	COG0678	peroxiredoxin activity
F544_RS06850	COG1946	Acyl-CoA thioesterase
F544_RS06855	COG3217	Mosc domain protein beta barrel domain protein
F544_RS06855	COG0633	Ferredoxin
F544_RS06865	COG0142	geranyltranstransferase activity
F544_RS06870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F544_RS06895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F544_RS06900	COG1686	Belongs to the peptidase S11 family
F544_RS06905	COG2975	iron-sulfur cluster assembly
F544_RS06910	COG0633	Ferredoxin
F544_RS06930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F544_RS06940	COG0822	iron-sulfur transferase activity
F544_RS06950	COG1959	2 iron, 2 sulfur cluster binding
F544_RS06955	COG3691	Protein conserved in bacteria
F544_RS06970	COG2914	Belongs to the UPF0125 (RnfH) family
F544_RS06975	COG2867	negative regulation of translational initiation
F544_RS06980	COG0709	Synthesizes selenophosphate from selenide and ATP
F544_RS06985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F544_RS07000	COG0494	nUDIX hydrolase
F544_RS07010	COG0302	gtp cyclohydrolase
F544_RS07020	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
F544_RS07025	COG1595	DNA-templated transcription, initiation
F544_RS07030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F544_RS07055	COG1674	ftsk spoiiie
F544_RS07065	COG0626	cystathionine gamma-synthase activity
F544_RS07070	COG2252	PERMEase
F544_RS07080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F544_RS07080	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F544_RS07090	COG0586	Pfam SNARE associated Golgi protein
F544_RS07105	COG4178	(ABC) transporter
F544_RS07110	COG4774	siderophore transport
F544_RS07125	COG0646	methionine synthase
F544_RS07125	COG1410	methionine synthase
F544_RS07130	COG0531	amino acid
F544_RS07145	COG1216	Glycosyl transferase, family 2
F544_RS07150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F544_RS07185	COG1468	defense response to virus
F544_RS07185	COG1518	maintenance of DNA repeat elements
F544_RS07200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F544_RS07200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F544_RS07205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F544_RS07210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F544_RS07215	COG0318	PFAM AMP-dependent synthetase and ligase
F544_RS07225	COG3026	antisigma factor binding
F544_RS07240	COG2350	Protein conserved in bacteria
F544_RS07245	COG1607	acyl-coa hydrolase
F544_RS07260	COG3092	negative regulation of chromosome organization
F544_RS07265	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F544_RS07270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F544_RS07285	COG1496	oxidoreductase activity
F544_RS07290	COG0251	oxidation-reduction process
F544_RS07300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F544_RS07305	COG0287	Prephenate dehydrogenase
F544_RS07305	COG1605	Chorismate mutase
F544_RS07310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F544_RS07315	COG0859	PFAM glycosyl transferase family 9
F544_RS07320	COG2920	part of a sulfur-relay system
F544_RS07325	COG0670	Belongs to the BI1 family
F544_RS07330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F544_RS07335	COG1132	(ABC) transporter
F544_RS07340	COG1346	cytolysis
F544_RS07345	COG1380	Effector of murein hydrolase LrgA
F544_RS07350	COG1199	ATP-dependent helicase activity
F544_RS07355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F544_RS07360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F544_RS07365	COG1792	Involved in formation and maintenance of cell shape
F544_RS07370	COG1077	Cell shape determining protein MreB Mrl
F544_RS07375	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F544_RS07380	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F544_RS07385	COG3266	domain, Protein
F544_RS07395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F544_RS07400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F544_RS07415	COG0750	zinc metalloprotease
F544_RS07420	COG0575	Belongs to the CDS family
F544_RS07425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F544_RS07435	COG1940	carbohydrate kinase activity
F544_RS07440	COG0671	phosphoesterase, PA-phosphatase related
F544_RS07445	COG1534	Rna-binding protein
F544_RS07450	COG0463	Glycosyl transferase, family 2
F544_RS07455	COG0859	PFAM glycosyl transferase family 9
F544_RS07465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F544_RS07485	COG1216	Glycosyl transferase, family 2
F544_RS07490	COG1027	Aspartate ammonia-lyase
F544_RS07495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F544_RS07505	COG0617	tRNA 3'-terminal CCA addition
F544_RS07510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F544_RS07515	COG1408	metallophosphoesterase
F544_RS07520	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F544_RS07525	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
F544_RS07535	COG2183	response to ionizing radiation
F544_RS07540	COG4591	ABC-type transport system involved in lipoprotein release permease component
F544_RS07545	COG1136	(ABC) transporter
F544_RS07555	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
F544_RS07570	COG1965	Belongs to the frataxin family
F544_RS07585	COG4172	Belongs to the ABC transporter superfamily
F544_RS07590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F544_RS07595	COG0601	transmembrane transport
F544_RS07605	COG2226	methyltransferase
F544_RS07610	COG2354	Protein conserved in bacteria
F544_RS07620	COG1942	4-Oxalocrotonate Tautomerase
F544_RS07625	COG0512	Glutamine amidotransferase of anthranilate synthase
F544_RS07630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F544_RS07635	COG0494	nUDIX hydrolase
F544_RS07650	COG4701	Protein of unknown function (DUF721)
F544_RS07655	COG3015	lipoprotein NlpE involved in copper resistance
F544_RS07665	COG0271	Belongs to the BolA IbaG family
F544_RS07670	COG3056	Lipoprotein
F544_RS07675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F544_RS07680	COG1678	Uncharacterized ACR, COG1678
F544_RS07695	COG0254	rRNA binding
F544_RS07700	COG0583	DNA-binding transcription factor activity
F544_RS07730	COG0460	homoserine dehydrogenase
F544_RS07730	COG0527	aspartate kinase activity
F544_RS07735	COG0083	homoserine kinase activity
F544_RS07740	COG2062	phosphohistidine phosphatase, SixA
F544_RS07745	COG0469	pyruvate kinase activity
F544_RS07750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F544_RS07760	COG1162	GTPase activity
F544_RS07770	COG2259	Doxx family
F544_RS07775	COG0583	DNA-binding transcription factor activity
F544_RS07780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F544_RS07785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F544_RS07790	COG1121	(ABC) transporter
F544_RS07795	COG0803	Belongs to the bacterial solute-binding protein 9 family
F544_RS07805	COG2608	mercury ion transmembrane transporter activity
F544_RS07815	COG3118	belongs to the thioredoxin family
F544_RS07825	COG0583	DNA-binding transcription factor activity
F544_RS07830	COG1011	Hydrolase
F544_RS07835	COG0251	oxidation-reduction process
F544_RS07840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F544_RS07845	COG0583	DNA-binding transcription factor activity
F544_RS07850	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F544_RS07855	COG1862	Preprotein translocase
F544_RS07860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F544_RS07865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F544_RS07875	COG4120	Belongs to the binding-protein-dependent transport system permease family
F544_RS07895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F544_RS07900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F544_RS07905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F544_RS07915	COG0495	leucyl-tRNA aminoacylation
F544_RS07920	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F544_RS07925	COG1466	dna polymerase III delta subunit
F544_RS07930	COG1305	Transglutaminase-like
F544_RS07940	COG2608	mercury ion transmembrane transporter activity
F544_RS07945	COG1216	Glycosyl transferase, family 2
F544_RS07950	COG1216	Glycosyl transferase, family 2
F544_RS07960	COG3306	glycosyltransferase involved in LPS biosynthesis
F544_RS07975	COG1083	cytidylyl-transferase
F544_RS07980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F544_RS07990	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F544_RS07995	COG4160	amino acid transport
F544_RS08000	COG4215	(ABC) transporter
F544_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F544_RS08010	COG1126	abc transporter atp-binding protein
F544_RS08015	COG4232	protein-disulfide reductase activity
F544_RS08050	COG2824	Alkylphosphonate utilization operon protein PhnA
F544_RS08060	COG0511	ligase activity, forming carbon-carbon bonds
F544_RS08060	COG5016	pyruvate
F544_RS08065	COG3630	sodium ion export across plasma membrane
F544_RS08070	COG1914	H( )-stimulated, divalent metal cation uptake system
F544_RS08075	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F544_RS08080	COG1984	allophanate hydrolase subunit 2
F544_RS08085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F544_RS08090	COG1793	dna ligase
F544_RS08105	COG0795	lipopolysaccharide-transporting ATPase activity
F544_RS08110	COG0795	lipopolysaccharide-transporting ATPase activity
F544_RS08120	COG3307	-O-antigen
F544_RS08125	COG1519	Transferase
F544_RS08140	COG0802	atpase or kinase
F544_RS08145	COG0860	N-Acetylmuramoyl-L-alanine amidase
F544_RS08145	COG1388	LysM domain
F544_RS08175	COG0210	DNA helicase
F544_RS08185	COG1074	ATP-dependent DNA helicase activity
F544_RS08195	COG0561	phosphatase activity
F544_RS08200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F544_RS08210	COG2932	Transcriptional regulator
F544_RS08215	COG0791	NLP P60 protein
F544_RS08225	COG3381	protein complex oligomerization
F544_RS08235	COG4591	ABC-type transport system involved in lipoprotein release permease component
F544_RS08265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F544_RS08295	COG3068	Protein conserved in bacteria
F544_RS08305	COG0676	glucose-6-phosphate 1-epimerase activity
F544_RS08310	COG1410	methionine synthase
F544_RS08310	COG0646	methionine synthase
F544_RS08325	COG1120	ATPase activity
F544_RS08340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F544_RS08345	COG0705	Rhomboid family
F544_RS08350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F544_RS08355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F544_RS08360	COG3023	N-Acetylmuramoyl-L-alanine amidase
F544_RS08365	COG0402	S-adenosylhomocysteine deaminase activity
F544_RS08370	COG1538	Outer membrane efflux protein
F544_RS08375	COG0842	Transport permease protein
F544_RS08380	COG1129	ABC transporter
F544_RS08380	COG0842	Transport permease protein
F544_RS08385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F544_RS08395	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F544_RS08405	COG0488	(ABC) transporter
F544_RS08435	COG0187	DNA topoisomerase II activity
F544_RS08445	COG1640	4-alpha-glucanotransferase
F544_RS08455	COG1138	Cytochrome C-type biogenesis protein
F544_RS08470	COG5007	Belongs to the BolA IbaG family
F544_RS08480	COG2854	intermembrane phospholipid transfer
F544_RS08485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F544_RS08490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F544_RS08495	COG1127	ABC transporter
F544_RS08505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F544_RS08510	COG0792	nuclease activity
F544_RS08525	COG0783	Belongs to the Dps family
F544_RS08530	COG0024	Methionine aminopeptidase
F544_RS08535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F544_RS08545	COG2990	Protein conserved in bacteria
F544_RS08550	COG3005	denitrification pathway
F544_RS08555	COG3043	anaerobic respiration
F544_RS08560	COG0348	domain, Protein
F544_RS08565	COG0437	4 iron, 4 sulfur cluster binding
F544_RS08570	COG0243	molybdopterin cofactor binding
F544_RS08580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F544_RS08580	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
F544_RS08585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F544_RS08595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F544_RS08600	COG2271	Major facilitator Superfamily
F544_RS08605	COG0584	glycerophosphoryl diester phosphodiesterase
F544_RS08610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F544_RS08620	COG0247	lactate metabolic process
F544_RS08625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F544_RS08630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F544_RS08640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F544_RS08640	COG0475	glutathione-regulated potassium exporter activity
F544_RS08645	COG1138	Cytochrome C-type biogenesis protein
F544_RS08655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F544_RS08660	COG3088	subunit of a heme lyase
F544_RS08660	COG4235	cytochrome complex assembly
F544_RS08665	COG4235	cytochrome complex assembly
F544_RS08665	COG3088	subunit of a heme lyase
F544_RS08685	COG1335	isochorismatase
F544_RS08705	COG0517	IMP dehydrogenase activity
F544_RS08705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F544_RS08710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F544_RS08715	COG1702	phosphate starvation-inducible protein PhoH
F544_RS08720	COG4143	(ABC) transporter
F544_RS08730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F544_RS08740	COG2137	regulation of response to DNA damage stimulus
F544_RS08750	COG0551	DNA topoisomerase type I activity
F544_RS08755	COG0009	L-threonylcarbamoyladenylate synthase
F544_RS08785	COG2960	long-chain fatty acid transporting porin activity
F544_RS08795	COG0516	GMP reductase activity
F544_RS08805	COG1966	Carbon starvation protein
F544_RS08820	COG2431	L-lysine efflux transmembrane transporter activity
F544_RS08830	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F544_RS08835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F544_RS08840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F544_RS08845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F544_RS08870	COG4796	Type ii and iii secretion system protein
F544_RS08875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F544_RS08880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F544_RS08885	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F544_RS08890	COG1280	lysine exporter protein (LysE YggA)
F544_RS08895	COG1119	ATPase activity
F544_RS08905	COG0366	Alpha amylase catalytic
F544_RS08910	COG1263	PTS System
F544_RS08910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F544_RS08915	COG4783	chaperone-mediated protein folding
F544_RS08920	COG0561	phosphatase activity
F544_RS08925	COG1040	competence protein
F544_RS08930	COG0084	hydrolase, TatD family'
F544_RS08935	COG2835	tetraacyldisaccharide 4'-kinase activity
F544_RS08940	COG1663	tetraacyldisaccharide 4'-kinase activity
F544_RS08945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F544_RS08955	COG2166	iron-sulfur cluster assembly
F544_RS08970	COG0512	Glutamine amidotransferase of anthranilate synthase
F544_RS08975	COG1322	Protein conserved in bacteria
F544_RS08990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F544_RS09000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F544_RS09020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F544_RS09020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F544_RS09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
F544_RS09055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F544_RS09065	COG0640	Transcriptional regulator
F544_RS09070	COG0009	L-threonylcarbamoyladenylate synthase
F544_RS09080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F544_RS09085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F544_RS09110	COG0560	Phosphoserine phosphatase
F544_RS09125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F544_RS09130	COG0354	folic acid binding
F544_RS09140	COG2995	paraquat-inducible protein a
F544_RS09160	COG3099	Belongs to the UPF0263 family
F544_RS09165	COG2252	PERMEase
F544_RS09170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F544_RS09175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F544_RS09180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F544_RS09190	COG0716	FMN binding
F544_RS09195	COG0735	belongs to the Fur family
F544_RS09200	COG3008	intermembrane lipid transfer
F544_RS09210	COG1132	(ABC) transporter
F544_RS09220	COG0534	Mate efflux family protein
F544_RS09225	COG0564	pseudouridine synthase activity
F544_RS09245	COG2723	6-phospho-beta-galactosidase activity
F544_RS09255	COG1575	Belongs to the MenA family. Type 1 subfamily
F544_RS09260	COG1720	tRNA m6t6A37 methyltransferase activity
F544_RS09270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F544_RS09290	COG0697	spore germination
F544_RS09295	COG3266	domain, Protein
F544_RS09300	COG0583	DNA-binding transcription factor activity
F544_RS09315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F544_RS09330	COG4145	pantothenate transmembrane transporter activity
F544_RS09340	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F544_RS09350	COG0762	integral membrane protein
F544_RS09355	COG3171	Protein conserved in bacteria
F544_RS09360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F544_RS09365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F544_RS09385	COG0628	permease
F544_RS09395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F544_RS09400	COG3590	peptidase
F544_RS09430	COG1442	glycosyl transferase family 8
F544_RS09470	COG0316	Belongs to the HesB IscA family
F544_RS09480	COG0733	neurotransmitter:sodium symporter activity
F544_RS09490	COG1621	beta-fructofuranosidase activity
F544_RS09495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F544_RS09500	COG0564	pseudouridine synthase activity
F544_RS09520	COG1611	Belongs to the LOG family
F544_RS09525	COG3593	DNA synthesis involved in DNA repair
F544_RS09530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F544_RS09535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F544_RS09540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F544_RS09545	COG2190	(PTS) system
F544_RS09550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F544_RS09555	COG3681	Belongs to the UPF0597 family
F544_RS09575	COG3012	SEC-C Motif Domain Protein
F544_RS09585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F544_RS09590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F544_RS09595	COG1349	DNA-binding transcription factor activity
F544_RS09605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F544_RS09610	COG1840	ABC-type Fe3 transport system, periplasmic component
F544_RS09630	COG4811	Protein of unknown function (DUF986)
F544_RS09635	COG3716	PTS system mannose fructose sorbose family IID component
F544_RS09640	COG3715	PTS system
F544_RS09645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F544_RS09645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F544_RS09650	COG1584	GPR1 FUN34 yaaH family protein
F544_RS09655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F544_RS09665	COG1120	ATPase activity
F544_RS09675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F544_RS09685	COG2177	Part of the ABC transporter FtsEX involved in
F544_RS09690	COG2884	Cell division ATP-binding protein ftsE
F544_RS09695	COG0552	protein localization to endoplasmic reticulum
F544_RS09700	COG0742	ribosomal rna small subunit methyltransferase
F544_RS09710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F544_RS09725	COG0546	phosphoglycolate phosphatase activity
F544_RS09730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F544_RS09735	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
F544_RS09740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F544_RS09745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F544_RS09755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F544_RS09770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F544_RS09780	COG2003	Belongs to the UPF0758 family
F544_RS09785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F544_RS09810	COG0252	asparaginase activity
F544_RS09830	COG1476	TRANSCRIPTIONal
F544_RS09850	COG0228	four-way junction DNA binding
F544_RS09860	COG0202	RNA polymerase activity
F544_RS09875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F544_RS09885	COG0201	protein transport
F544_RS09890	COG0200	Binds to the 23S rRNA
F544_RS09900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F544_RS09910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F544_RS09920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F544_RS09940	COG0018	arginyl-trna synthetase
F544_RS09945	COG3102	Protein conserved in bacteria
F544_RS09950	COG3133	Outer membrane lipoprotein
F544_RS09960	COG1289	transmembrane transporter activity
F544_RS09970	COG2129	metallophosphoesterase
F544_RS09975	COG3172	ATPase kinase involved in NAD metabolism
F544_RS09980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F544_RS10005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F544_RS10010	COG1393	Belongs to the ArsC family
F544_RS10015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F544_RS10040	COG0149	triose-phosphate isomerase activity
F544_RS10050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F544_RS10055	COG1238	metal cluster binding
F544_RS10065	COG1388	LysM domain
F544_RS10065	COG4942	peptidase
F544_RS10075	COG2818	Glycosylase
F544_RS10090	COG0494	nUDIX hydrolase
F544_RS10100	COG1555	photosystem II stabilization
F544_RS10105	COG3266	domain, Protein
F544_RS10105	COG3061	Opacity-associated protein A
F544_RS10115	COG0859	PFAM glycosyl transferase family 9
F544_RS10130	COG0598	Magnesium transport protein CorA
F544_RS10145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F544_RS10185	COG0545	Peptidyl-prolyl cis-trans isomerase
F544_RS10240	COG0582	viral genome integration into host DNA
F544_RS10355	COG0740	serine-type endopeptidase activity
F544_RS10395	COG3772	lysozyme
F544_RS10405	COG3617	BRO family, N-terminal domain
F544_RS10440	COG1403	HNH endonuclease
F544_RS10525	COG5532	Uncharacterized conserved protein (DUF2303)
F544_RS10555	COG0582	viral genome integration into host DNA
F544_RS10565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F544_RS10575	COG0592	DNA-directed DNA polymerase activity
F544_RS10580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F544_RS10590	COG0255	Belongs to the universal ribosomal protein uL29 family
F544_RS10600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F544_RS10605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F544_RS10610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F544_RS10620	COG0089	rRNA binding
F544_RS10625	COG0088	Forms part of the polypeptide exit tunnel
F544_RS10635	COG0051	transcription antitermination factor activity, RNA binding
F544_RS10640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F544_RS10650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F544_RS10655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F544_RS10680	COG0805	protein transport
F544_RS10685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F544_RS10705	COG2226	methyltransferase
F544_RS10710	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
F544_RS10715	COG1970	mechanosensitive ion channel activity
F544_RS10725	COG1126	abc transporter atp-binding protein
F544_RS10730	COG0765	amino acid transport
F544_RS10735	COG1022	Amp-dependent synthetase and ligase
F544_RS10740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F544_RS10765	COG0204	Acyl-transferase
F544_RS10780	COG0730	response to heat
F544_RS10785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F544_RS10805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F544_RS10820	COG3645	SOS response
F544_RS10840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F544_RS10850	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F544_RS10880	COG0431	NADPH-dependent FMN reductase
F544_RS10885	COG4974	Belongs to the 'phage' integrase family
F544_RS10920	COG0758	DNA mediated transformation
F544_RS10930	COG0259	pyridoxamine-phosphate oxidase activity
F544_RS10940	COG1609	Transcriptional regulator
F544_RS10955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F544_RS10985	COG0745	RESPONSE REGULATOR receiver
F544_RS10990	COG0642	Histidine kinase
F544_RS11055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F544_RS11080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F544_RS11085	COG1028	Short-chain dehydrogenase reductase Sdr
F544_RS11100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F544_RS11130	COG0085	RNA polymerase activity
F544_RS11140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F544_RS11145	COG0081	regulation of translation
F544_RS11160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F544_RS11165	COG0019	diaminopimelate decarboxylase activity
F544_RS11175	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
F544_RS11190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F544_RS11195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F544_RS11200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F544_RS11205	COG3477	response to acidic pH
F544_RS11215	COG0346	lactoylglutathione lyase activity
F544_RS11220	COG1194	a g-specific adenine glycosylase
F544_RS11245	COG1414	Transcriptional regulator
F544_RS11255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F544_RS11260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F544_RS11265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F544_RS11275	COG3718	enzyme involved in inositol metabolism
F544_RS11290	COG1129	ABC transporter
F544_RS11295	COG1172	Belongs to the binding-protein-dependent transport system permease family
F544_RS11300	COG0673	inositol 2-dehydrogenase activity
F544_RS11305	COG0673	inositol 2-dehydrogenase activity
F544_RS11315	COG3962	Belongs to the TPP enzyme family
F544_RS11330	COG2190	(PTS) system
F544_RS11330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F544_RS11330	COG1263	PTS System
F544_RS11335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F544_RS11355	COG1686	Belongs to the peptidase S11 family
F544_RS11365	COG0772	Belongs to the SEDS family
F544_RS11400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F544_RS11425	COG0187	DNA topoisomerase II activity
F544_RS11430	COG3210	domain, Protein