locus-tag	class	description
AB656_RS00005	COG1131	(ABC) transporter
AB656_RS00060	COG0747	negative chemotaxis
AB656_RS00070	COG0745	RESPONSE REGULATOR receiver
AB656_RS00080	COG2323	membrane
AB656_RS00095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AB656_RS00145	COG0356	it plays a direct role in the translocation of protons across the membrane
AB656_RS00180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AB656_RS00190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AB656_RS00195	COG0545	Peptidyl-prolyl cis-trans isomerase
AB656_RS00255	COG2252	PERMEase
AB656_RS00265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AB656_RS00300	COG1770	oligopeptidase
AB656_RS00310	COG0095	Lipoate-protein ligase
AB656_RS00315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AB656_RS00320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AB656_RS00325	COG1216	Glycosyl transferase, family 2
AB656_RS00330	COG1349	DNA-binding transcription factor activity
AB656_RS00340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AB656_RS00345	COG2211	Major facilitator Superfamily
AB656_RS00350	COG0366	Alpha amylase catalytic
AB656_RS00355	COG1609	Transcriptional regulator
AB656_RS00360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AB656_RS00365	COG1194	a g-specific adenine glycosylase
AB656_RS00375	COG2851	Citrate transporter
AB656_RS00380	COG3835	regulator
AB656_RS00385	COG4948	Mandelate Racemase Muconate Lactonizing
AB656_RS00395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AB656_RS00400	COG1929	Belongs to the glycerate kinase type-1 family
AB656_RS00405	COG2084	Dehydrogenase
AB656_RS00440	COG0714	Associated with various cellular activities
AB656_RS00465	COG0210	DNA helicase
AB656_RS00480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AB656_RS00540	COG1063	alcohol dehydrogenase
AB656_RS00550	COG0583	DNA-binding transcription factor activity
AB656_RS00575	COG3940	Belongs to the glycosyl hydrolase 43 family
AB656_RS00580	COG2211	Major facilitator Superfamily
AB656_RS00595	COG0457	Tetratricopeptide repeat
AB656_RS00605	COG0395	ABC-type sugar transport system, permease component
AB656_RS00635	COG1722	exodeoxyribonuclease VII activity
AB656_RS00640	COG1570	exodeoxyribonuclease VII activity
AB656_RS00645	COG1924	4 iron, 4 sulfur cluster binding
AB656_RS00655	COG2211	Major facilitator Superfamily
AB656_RS00665	COG1874	Beta-galactosidase
AB656_RS00670	COG1472	Belongs to the glycosyl hydrolase 3 family
AB656_RS00685	COG1609	Transcriptional regulator
AB656_RS00700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AB656_RS00705	COG0667	Aldo Keto reductase
AB656_RS00710	COG1136	(ABC) transporter
AB656_RS00710	COG0577	efflux transmembrane transporter activity
AB656_RS00730	COG0587	DNA-directed DNA polymerase activity
AB656_RS00790	COG1473	amidohydrolase
AB656_RS00800	COG1473	amidohydrolase
AB656_RS00835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AB656_RS00865	COG0587	DNA-directed DNA polymerase activity
AB656_RS00885	COG1643	Atp-dependent helicase
AB656_RS00890	COG2264	protein methyltransferase activity
AB656_RS00895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AB656_RS00945	COG0768	penicillin binding
AB656_RS00955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AB656_RS00970	COG0772	Belongs to the SEDS family
AB656_RS00995	COG2390	Transcriptional regulator
AB656_RS01275	COG1611	Belongs to the LOG family
AB656_RS01285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AB656_RS01290	COG1053	succinate dehydrogenase
AB656_RS01320	COG1136	(ABC) transporter
AB656_RS01320	COG0577	efflux transmembrane transporter activity
AB656_RS01330	COG2197	response regulator
AB656_RS01335	COG4585	Histidine kinase
AB656_RS01345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AB656_RS01350	COG0012	GTP binding
AB656_RS01355	COG2910	NAD(P)H-binding
AB656_RS01370	COG1116	anion transmembrane transporter activity
AB656_RS01380	COG2249	NAD(P)H dehydrogenase (quinone) activity
AB656_RS01435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AB656_RS01460	COG1316	TRANSCRIPTIONal
AB656_RS01465	COG1316	TRANSCRIPTIONal
AB656_RS01490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AB656_RS01505	COG2205	protein histidine kinase activity
AB656_RS01510	COG0745	RESPONSE REGULATOR receiver
AB656_RS01525	COG1121	(ABC) transporter
AB656_RS01535	COG0539	negative regulation of cytoplasmic translation
AB656_RS01540	COG0237	dephospho-CoA kinase activity
AB656_RS01555	COG0469	pyruvate kinase activity
AB656_RS01560	COG0494	nUDIX hydrolase
AB656_RS01580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AB656_RS01585	COG1051	belongs to the nudix hydrolase family
AB656_RS01610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AB656_RS01615	COG0280	phosphate acetyltransferase
AB656_RS01615	COG0857	belongs to the CobB CobQ family
AB656_RS01650	COG0300	oxidoreductase activity
AB656_RS01660	COG0436	Aminotransferase
AB656_RS01675	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AB656_RS01720	COG0588	phosphoglycerate mutase activity
AB656_RS01760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AB656_RS01775	COG0719	Fe-S assembly protein
AB656_RS01780	COG0396	ATPase activity
AB656_RS01790	COG0822	iron-sulfur transferase activity
AB656_RS01795	COG2151	metal-sulfur cluster biosynthetic enzyme
AB656_RS01800	COG2233	PERMEase
AB656_RS01810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AB656_RS01820	COG0640	Transcriptional regulator
AB656_RS01840	COG0537	adenosine 5'-monophosphoramidase activity
AB656_RS01860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AB656_RS01880	COG0598	Magnesium transport protein CorA
AB656_RS01885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AB656_RS01895	COG1555	photosystem II stabilization
AB656_RS01895	COG1596	polysaccharide export
AB656_RS01910	COG0802	atpase or kinase
AB656_RS01920	COG0456	acetyltransferase
AB656_RS01945	COG0028	Belongs to the TPP enzyme family
AB656_RS01960	COG1022	Amp-dependent synthetase and ligase
AB656_RS01990	COG0575	Belongs to the CDS family
AB656_RS02005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AB656_RS02010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AB656_RS02050	COG4581	dead DEAH box helicase
AB656_RS02095	COG1609	Transcriptional regulator
AB656_RS02100	COG1653	transport
AB656_RS02105	COG1175	transmembrane transport
AB656_RS02110	COG0395	ABC-type sugar transport system, permease component
AB656_RS02115	COG1501	Belongs to the glycosyl hydrolase 31 family
AB656_RS02130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AB656_RS02135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AB656_RS02145	COG0789	Transcriptional regulator
AB656_RS02160	COG1187	pseudouridine synthase activity
AB656_RS02165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AB656_RS02205	COG0438	transferase activity, transferring glycosyl groups
AB656_RS02215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AB656_RS02250	COG0477	Major facilitator Superfamily
AB656_RS02290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AB656_RS02295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AB656_RS02335	COG0488	(ABC) transporter
AB656_RS02340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AB656_RS02340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AB656_RS02345	COG0588	phosphoglycerate mutase activity
AB656_RS02350	COG0583	DNA-binding transcription factor activity
AB656_RS02365	COG0167	dihydroorotate dehydrogenase activity
AB656_RS02370	COG0543	2 iron, 2 sulfur cluster binding
AB656_RS02375	COG0284	orotidine-5'-phosphate decarboxylase activity
AB656_RS02400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AB656_RS02410	COG2062	phosphohistidine phosphatase, SixA
AB656_RS02450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AB656_RS02465	COG0406	alpha-ribazole phosphatase activity
AB656_RS02470	COG0799	negative regulation of ribosome biogenesis
AB656_RS02495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AB656_RS02515	COG1132	(ABC) transporter
AB656_RS02520	COG1132	(ABC) transporter
AB656_RS02530	COG1131	(ABC) transporter
AB656_RS02540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AB656_RS02545	COG0497	DNA recombination
AB656_RS02575	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AB656_RS02585	COG1882	Formate acetyltransferase
AB656_RS02600	COG0477	Major facilitator Superfamily
AB656_RS02610	COG3304	Inner membrane component domain
AB656_RS02615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AB656_RS02655	COG1715	Restriction endonuclease
AB656_RS02675	COG1940	carbohydrate kinase activity
AB656_RS02685	COG0765	amino acid transport
AB656_RS02690	COG0765	amino acid transport
AB656_RS02695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AB656_RS02700	COG1126	abc transporter atp-binding protein
AB656_RS02715	COG1196	nuclear chromosome segregation
AB656_RS02720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AB656_RS02745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AB656_RS02750	COG1201	RNA secondary structure unwinding
AB656_RS02755	COG0187	DNA topoisomerase II activity
AB656_RS02760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AB656_RS02770	COG0142	geranyltranstransferase activity
AB656_RS02795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AB656_RS02800	COG2137	regulation of response to DNA damage stimulus
AB656_RS02815	COG1396	sequence-specific DNA binding
AB656_RS02820	COG1058	Belongs to the CinA family
AB656_RS02820	COG1546	Belongs to the CinA family
AB656_RS02825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AB656_RS02850	COG2357	RelA SpoT domain protein
AB656_RS02855	COG0656	L-ascorbic acid biosynthetic process
AB656_RS02860	COG0670	Belongs to the BI1 family
AB656_RS02895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AB656_RS02900	COG0601	transmembrane transport
AB656_RS02905	COG4166	transmembrane transport
AB656_RS02910	COG4166	transmembrane transport
AB656_RS02915	COG4166	transmembrane transport
AB656_RS02960	COG1217	gtp-binding protein TYPA
AB656_RS02965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AB656_RS02970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AB656_RS02995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AB656_RS03005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AB656_RS03005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AB656_RS03015	COG1393	Belongs to the ArsC family
AB656_RS03030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AB656_RS03035	COG2017	converts alpha-aldose to the beta-anomer
AB656_RS03045	COG1595	DNA-templated transcription, initiation
AB656_RS03065	COG1794	racemase activity, acting on amino acids and derivatives
AB656_RS03070	COG1196	nuclear chromosome segregation
AB656_RS03075	COG0285	dihydrofolate synthase activity
AB656_RS03080	COG0006	proline dipeptidase activity
AB656_RS03095	COG1940	carbohydrate kinase activity
AB656_RS03105	COG1940	carbohydrate kinase activity
AB656_RS03110	COG1070	Carbohydrate kinase
AB656_RS03115	COG4214	carbohydrate transport
AB656_RS03135	COG3142	Participates in the control of copper homeostasis
AB656_RS03140	COG0471	metal ion transport
AB656_RS03145	COG0281	malic enzyme
AB656_RS03160	COG0604	alcohol dehydrogenase
AB656_RS03170	COG1250	3-hydroxyacyl-CoA dehydrogenase
AB656_RS03220	COG0647	UMP catabolic process
AB656_RS03255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AB656_RS03265	COG1122	ATPase activity
AB656_RS03270	COG4721	ABC-type cobalt transport system, permease component
AB656_RS03275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AB656_RS03305	COG1136	(ABC) transporter
AB656_RS03325	COG2151	metal-sulfur cluster biosynthetic enzyme
AB656_RS03325	COG0489	protein tyrosine kinase activity
AB656_RS03345	COG0436	Aminotransferase
AB656_RS03350	COG1940	carbohydrate kinase activity
AB656_RS03365	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AB656_RS03385	COG1278	Cold shock
AB656_RS03395	COG4214	carbohydrate transport
AB656_RS03410	COG1940	carbohydrate kinase activity
AB656_RS03415	COG1129	ABC transporter
AB656_RS03425	COG2205	protein histidine kinase activity
AB656_RS03430	COG0745	RESPONSE REGULATOR receiver
AB656_RS03450	COG1278	Cold shock
AB656_RS03465	COG0714	Associated with various cellular activities
AB656_RS03505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AB656_RS03595	COG3189	MarR family transcriptional regulator
AB656_RS03630	COG2205	protein histidine kinase activity
AB656_RS03635	COG0745	RESPONSE REGULATOR receiver
AB656_RS03655	COG0358	DNA primase activity
AB656_RS03665	COG1764	response to oxidative stress
AB656_RS03670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AB656_RS03685	COG0514	ATP-dependent DNA helicase (RecQ)
AB656_RS03690	COG4608	Belongs to the ABC transporter superfamily
AB656_RS03700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AB656_RS03705	COG0601	transmembrane transport
AB656_RS03710	COG0747	negative chemotaxis
AB656_RS03725	COG0564	pseudouridine synthase activity
AB656_RS03730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AB656_RS03735	COG1126	abc transporter atp-binding protein
AB656_RS03740	COG0765	amino acid transport
AB656_RS03745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AB656_RS03755	COG1388	LysM domain
AB656_RS03755	COG3942	CHAP domain
AB656_RS03765	COG2884	Cell division ATP-binding protein ftsE
AB656_RS03770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AB656_RS03775	COG0024	Methionine aminopeptidase
AB656_RS03785	COG3590	peptidase
AB656_RS03795	COG0708	Exodeoxyribonuclease III
AB656_RS03805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AB656_RS03820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AB656_RS03830	COG1464	Belongs to the NlpA lipoprotein family
AB656_RS03835	COG2011	ABC-type metal ion transport system permease component
AB656_RS03840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AB656_RS03860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AB656_RS04075	COG0629	single-stranded DNA binding
AB656_RS04105	COG3617	BRO family, N-terminal domain
AB656_RS04145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AB656_RS04170	COG2094	Belongs to the DNA glycosylase MPG family
AB656_RS04175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AB656_RS04180	COG0477	Major facilitator Superfamily
AB656_RS04210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AB656_RS04220	COG4948	Mandelate Racemase Muconate Lactonizing
AB656_RS04275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AB656_RS04280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AB656_RS04285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AB656_RS04300	COG1215	transferase activity, transferring glycosyl groups
AB656_RS04310	COG1215	transferase activity, transferring glycosyl groups
AB656_RS04340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AB656_RS04360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AB656_RS04365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AB656_RS04380	COG0589	response to stress
AB656_RS04390	COG1388	LysM domain
AB656_RS04390	COG3942	CHAP domain
AB656_RS04405	COG5002	protein histidine kinase activity
AB656_RS04410	COG0704	Plays a role in the regulation of phosphate uptake
AB656_RS04420	COG1575	Belongs to the MenA family. Type 1 subfamily
AB656_RS04425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AB656_RS04440	COG4181	ATPase activity
AB656_RS04465	COG4221	oxidoreductase activity
AB656_RS04475	COG2814	Major facilitator Superfamily
AB656_RS04510	COG2197	response regulator
AB656_RS04520	COG2249	NAD(P)H dehydrogenase (quinone) activity
AB656_RS04525	COG0667	Aldo Keto reductase
AB656_RS04540	COG1129	ABC transporter
AB656_RS04560	COG0814	amino acid
AB656_RS04565	COG1760	l-serine dehydratase
AB656_RS04570	COG1760	l-serine dehydratase
AB656_RS04575	COG1597	lipid kinase activity
AB656_RS04575	COG1803	Methylglyoxal synthase
AB656_RS04600	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AB656_RS04620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AB656_RS04625	COG4988	ABC transporter
AB656_RS04630	COG1294	oxidase, subunit
AB656_RS04635	COG1271	oxidase subunit
AB656_RS04660	COG0602	queuosine metabolic process
AB656_RS04665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AB656_RS04665	COG1328	CTP reductase activity
AB656_RS04685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AB656_RS04740	COG1088	dTDP-glucose 4,6-dehydratase activity
AB656_RS04750	COG3475	LICD family
AB656_RS04785	COG1216	Glycosyl transferase, family 2
AB656_RS04805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AB656_RS04805	COG1321	iron dependent repressor
AB656_RS04810	COG1914	H( )-stimulated, divalent metal cation uptake system
AB656_RS04905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AB656_RS04935	COG1530	ribonuclease E activity
AB656_RS04955	COG1322	Protein conserved in bacteria
AB656_RS04960	COG2217	Heavy metal translocating P-type atpase
AB656_RS04975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AB656_RS05010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AB656_RS05020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AB656_RS05020	COG1754	DNA topoisomerase type I activity
AB656_RS05040	COG0516	GMP reductase activity
AB656_RS05070	COG1260	myo-inositol-1-phosphate synthase
AB656_RS05075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AB656_RS05080	COG0583	DNA-binding transcription factor activity
AB656_RS05120	COG2814	Major facilitator Superfamily
AB656_RS05145	COG2390	Transcriptional regulator
AB656_RS05195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AB656_RS05200	COG0406	alpha-ribazole phosphatase activity
AB656_RS05200	COG0494	nUDIX hydrolase
AB656_RS05210	COG2271	Major facilitator Superfamily
AB656_RS05230	COG0584	glycerophosphoryl diester phosphodiesterase
AB656_RS05250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AB656_RS05255	COG0305	Participates in initiation and elongation during chromosome replication
AB656_RS05260	COG0534	Mate efflux family protein
AB656_RS05320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AB656_RS05340	COG0512	Glutamine amidotransferase of anthranilate synthase
AB656_RS05365	COG2723	6-phospho-beta-galactosidase activity
AB656_RS05370	COG3250	beta-galactosidase activity
AB656_RS05375	COG2211	Major facilitator Superfamily
AB656_RS05385	COG3833	ABC-type maltose transport systems, permease component
AB656_RS05460	COG1250	3-hydroxyacyl-CoA dehydrogenase
AB656_RS05465	COG0477	Major facilitator Superfamily
AB656_RS05495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AB656_RS05510	COG1113	amino acid transport
AB656_RS05515	COG1113	amino acid transport
AB656_RS05520	COG0833	amino acid
AB656_RS05525	COG0833	amino acid
AB656_RS05535	COG3048	D-serine ammonia-lyase activity
AB656_RS05540	COG2610	gluconate transmembrane transporter activity
AB656_RS05565	COG0191	fructose-bisphosphate aldolase activity
AB656_RS05575	COG1653	transport
AB656_RS05590	COG1609	Transcriptional regulator
AB656_RS05605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AB656_RS05615	COG3842	ATPase activity
AB656_RS05625	COG1653	transport
AB656_RS05635	COG0395	ABC-type sugar transport system, permease component
AB656_RS05645	COG1609	Transcriptional regulator
AB656_RS05665	COG3583	domain protein
AB656_RS05680	COG0617	tRNA 3'-terminal CCA addition
AB656_RS05710	COG0492	ferredoxin-NADP+ reductase activity
AB656_RS05720	COG1192	Involved in chromosome partitioning
AB656_RS05735	COG1847	R3H domain protein
AB656_RS05765	COG0592	DNA-directed DNA polymerase activity
AB656_RS05780	COG0187	DNA topoisomerase II activity
AB656_RS05785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AB656_RS05810	COG2271	Major facilitator Superfamily
AB656_RS05815	COG3534	alpha-L-arabinofuranosidase
AB656_RS05830	COG0395	ABC-type sugar transport system, permease component
AB656_RS05835	COG1609	Transcriptional regulator
AB656_RS05875	COG1132	(ABC) transporter
AB656_RS05910	COG0783	Belongs to the Dps family
AB656_RS05915	COG1253	flavin adenine dinucleotide binding
AB656_RS05935	COG1653	transport
AB656_RS05940	COG1175	transmembrane transport
AB656_RS05945	COG0395	ABC-type sugar transport system, permease component
AB656_RS05960	COG0180	Tryptophanyl-tRNA synthetase
AB656_RS06005	COG0367	asparagine synthase
AB656_RS06015	COG0515	serine threonine protein kinase
AB656_RS06020	COG0768	penicillin binding
AB656_RS06065	COG1937	Protein conserved in bacteria
AB656_RS06095	COG0343	queuine tRNA-ribosyltransferase activity
AB656_RS06100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AB656_RS06110	COG2217	Heavy metal translocating P-type atpase
AB656_RS06145	COG1940	carbohydrate kinase activity
AB656_RS06165	COG0025	NhaP-type Na H and K H
AB656_RS06175	COG0590	tRNA wobble adenosine to inosine editing
AB656_RS06175	COG0037	tRNA processing
AB656_RS06180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AB656_RS06185	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AB656_RS06190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AB656_RS06235	COG1175	transmembrane transport
AB656_RS06240	COG0395	ABC-type sugar transport system, permease component
AB656_RS06245	COG1609	Transcriptional regulator
AB656_RS06250	COG0778	Nitroreductase
AB656_RS06270	COG1609	Transcriptional regulator
AB656_RS06295	COG0366	Alpha amylase catalytic
AB656_RS06310	COG0484	heat shock protein binding
AB656_RS06315	COG0789	Transcriptional regulator
AB656_RS06320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AB656_RS06380	COG0738	Major facilitator superfamily
AB656_RS06390	COG0149	triose-phosphate isomerase activity
AB656_RS06395	COG0028	Belongs to the TPP enzyme family
AB656_RS06405	COG0586	Pfam SNARE associated Golgi protein
AB656_RS06440	COG0084	hydrolase, TatD family'
AB656_RS06450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AB656_RS06470	COG0395	ABC-type sugar transport system, permease component
AB656_RS06485	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AB656_RS06500	COG0363	glucosamine-6-phosphate deaminase activity
AB656_RS06540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AB656_RS06550	COG0477	Major facilitator Superfamily
AB656_RS06565	COG1846	Transcriptional regulator
AB656_RS06570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AB656_RS06580	COG0814	amino acid
AB656_RS06585	COG3681	Belongs to the UPF0597 family
AB656_RS06605	COG4770	biotin carboxylase activity
AB656_RS06610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AB656_RS06625	COG1309	transcriptional regulator
AB656_RS06690	COG1518	maintenance of DNA repeat elements
AB656_RS06695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AB656_RS06725	COG1704	LemA family
AB656_RS06745	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AB656_RS06755	COG3579	cysteine-type endopeptidase activity
AB656_RS06760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AB656_RS06790	COG1970	mechanosensitive ion channel activity
AB656_RS06825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AB656_RS06850	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AB656_RS06855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AB656_RS06880	COG3051	citrate lyase alpha subunit
AB656_RS06890	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AB656_RS06910	COG0531	amino acid
AB656_RS06920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AB656_RS06930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AB656_RS06935	COG1739	Uncharacterized protein family UPF0029
AB656_RS06960	COG1454	alcohol dehydrogenase
AB656_RS06960	COG1012	belongs to the aldehyde dehydrogenase family
AB656_RS07010	COG0255	Belongs to the universal ribosomal protein uL29 family
AB656_RS07160	COG0196	riboflavin kinase activity
AB656_RS07190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AB656_RS07230	COG0668	transmembrane transport
AB656_RS07235	COG2153	protein acetylation
AB656_RS07245	COG1846	Transcriptional regulator
AB656_RS07255	COG1132	(ABC) transporter
AB656_RS07265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AB656_RS07270	COG0742	ribosomal rna small subunit methyltransferase
AB656_RS07280	COG0247	lactate metabolic process
AB656_RS07285	COG1139	Iron-sulfur cluster binding protein
AB656_RS07290	COG1556	Lactate utilization protein
AB656_RS07300	COG1837	Belongs to the UPF0109 family
AB656_RS07325	COG0512	Glutamine amidotransferase of anthranilate synthase
AB656_RS07325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AB656_RS07330	COG0488	(ABC) transporter
AB656_RS07335	COG0440	acetolactate synthase activity
AB656_RS07375	COG0667	Aldo Keto reductase
AB656_RS07420	COG0662	Cupin 2, conserved barrel domain protein
AB656_RS07420	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AB656_RS07445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AB656_RS07450	COG1609	Transcriptional regulator
AB656_RS07470	COG0656	L-ascorbic acid biosynthetic process
AB656_RS07480	COG2814	Major facilitator Superfamily