locus-tag	class	description
ET527_RS00010	COG0592	DNA-directed DNA polymerase activity
ET527_RS00025	COG0187	DNA topoisomerase II activity
ET527_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ET527_RS00045	COG1272	protein, Hemolysin III
ET527_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ET527_RS00055	COG2814	Major facilitator Superfamily
ET527_RS00070	COG1970	mechanosensitive ion channel activity
ET527_RS00115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ET527_RS00120	COG2226	methyltransferase
ET527_RS00225	COG0583	DNA-binding transcription factor activity
ET527_RS00240	COG3231	kanamycin kinase activity
ET527_RS00280	COG0783	Belongs to the Dps family
ET527_RS00285	COG1253	flavin adenine dinucleotide binding
ET527_RS00290	COG0288	reversible hydration of carbon dioxide
ET527_RS00295	COG1609	Transcriptional regulator
ET527_RS00315	COG1609	Transcriptional regulator
ET527_RS00320	COG3534	alpha-L-arabinofuranosidase
ET527_RS00340	COG0656	L-ascorbic acid biosynthetic process
ET527_RS00345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ET527_RS00360	COG0180	Tryptophanyl-tRNA synthetase
ET527_RS00375	COG0058	SHG alpha-glucan phosphorylase activity
ET527_RS00415	COG3764	Sortase (surface protein transpeptidase)
ET527_RS00430	COG0515	serine threonine protein kinase
ET527_RS00435	COG0768	penicillin binding
ET527_RS00470	COG0697	spore germination
ET527_RS00485	COG2226	methyltransferase
ET527_RS00495	COG2261	transglycosylase associated protein
ET527_RS00500	COG2261	transglycosylase associated protein
ET527_RS00525	COG2217	Heavy metal translocating P-type atpase
ET527_RS00530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ET527_RS00545	COG0343	queuine tRNA-ribosyltransferase activity
ET527_RS00570	COG2814	Major facilitator Superfamily
ET527_RS00585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ET527_RS00615	COG0667	Aldo Keto reductase
ET527_RS00655	COG1063	alcohol dehydrogenase
ET527_RS00660	COG0583	DNA-binding transcription factor activity
ET527_RS00670	COG0191	fructose-bisphosphate aldolase activity
ET527_RS00680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET527_RS00730	COG2211	Major facilitator Superfamily
ET527_RS00740	COG4770	biotin carboxylase activity
ET527_RS00770	COG0477	Major facilitator Superfamily
ET527_RS00830	COG1132	(ABC) transporter
ET527_RS00835	COG0390	transport system, permease component
ET527_RS00840	COG1113	amino acid transport
ET527_RS00845	COG0577	efflux transmembrane transporter activity
ET527_RS00845	COG1136	(ABC) transporter
ET527_RS00855	COG1113	amino acid transport
ET527_RS00870	COG0577	efflux transmembrane transporter activity
ET527_RS00875	COG1136	(ABC) transporter
ET527_RS00875	COG0577	efflux transmembrane transporter activity
ET527_RS00885	COG1846	Transcriptional regulator
ET527_RS00905	COG0671	phosphoesterase, PA-phosphatase related
ET527_RS00910	COG0110	maltose O-acetyltransferase activity
ET527_RS00955	COG1129	ABC transporter
ET527_RS00990	COG1309	transcriptional regulator
ET527_RS01010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ET527_RS01020	COG0305	Participates in initiation and elongation during chromosome replication
ET527_RS01025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ET527_RS01060	COG0406	alpha-ribazole phosphatase activity
ET527_RS01060	COG0494	nUDIX hydrolase
ET527_RS01155	COG1260	myo-inositol-1-phosphate synthase
ET527_RS01170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ET527_RS01170	COG1754	DNA topoisomerase type I activity
ET527_RS01235	COG0406	alpha-ribazole phosphatase activity
ET527_RS01295	COG0446	pyridine nucleotide-disulphide oxidoreductase
ET527_RS01305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ET527_RS01360	COG0436	Aminotransferase
ET527_RS01375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ET527_RS01375	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ET527_RS01385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ET527_RS01400	COG0742	ribosomal rna small subunit methyltransferase
ET527_RS01415	COG1837	Belongs to the UPF0109 family
ET527_RS01455	COG0488	(ABC) transporter
ET527_RS01465	COG0440	acetolactate synthase activity
ET527_RS01505	COG0667	Aldo Keto reductase
ET527_RS01575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ET527_RS01595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET527_RS01600	COG1530	ribonuclease E activity
ET527_RS01640	COG0436	Aminotransferase
ET527_RS01675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ET527_RS01675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ET527_RS01680	COG1268	BioY protein
ET527_RS01685	COG4770	biotin carboxylase activity
ET527_RS01690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ET527_RS01715	COG0039	L-malate dehydrogenase activity
ET527_RS01730	COG1704	LemA family
ET527_RS01740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ET527_RS01745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ET527_RS01765	COG0826	peptidase U32
ET527_RS01785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ET527_RS01795	COG3579	cysteine-type endopeptidase activity
ET527_RS01800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ET527_RS01805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ET527_RS01805	COG2755	lipolytic protein G-D-S-L family
ET527_RS01810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ET527_RS01815	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ET527_RS01825	COG0745	RESPONSE REGULATOR receiver
ET527_RS01840	COG0581	inorganic phosphate transmembrane transporter activity
ET527_RS01850	COG2252	PERMEase
ET527_RS01935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ET527_RS01940	COG0531	amino acid
ET527_RS01955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ET527_RS01965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ET527_RS01970	COG1739	Uncharacterized protein family UPF0029
ET527_RS02005	COG1012	belongs to the aldehyde dehydrogenase family
ET527_RS02005	COG1454	alcohol dehydrogenase
ET527_RS02065	COG0255	Belongs to the universal ribosomal protein uL29 family
ET527_RS02200	COG0196	riboflavin kinase activity
ET527_RS02225	COG0328	RNA-DNA hybrid ribonuclease activity
ET527_RS02245	COG1597	lipid kinase activity
ET527_RS02245	COG1803	Methylglyoxal synthase
ET527_RS02270	COG2197	response regulator
ET527_RS02290	COG0626	cystathionine gamma-synthase activity
ET527_RS02300	COG2873	o-acetylhomoserine
ET527_RS02310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ET527_RS02325	COG3579	cysteine-type endopeptidase activity
ET527_RS02330	COG0531	amino acid
ET527_RS02340	COG1113	amino acid transport
ET527_RS02355	COG4716	Myosin-crossreactive antigen
ET527_RS02360	COG1063	alcohol dehydrogenase
ET527_RS02365	COG1028	Short-chain dehydrogenase reductase Sdr
ET527_RS02365	COG3321	synthase
ET527_RS02365	COG0604	alcohol dehydrogenase
ET527_RS02375	COG5002	protein histidine kinase activity
ET527_RS02380	COG0704	Plays a role in the regulation of phosphate uptake
ET527_RS02385	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ET527_RS02390	COG1705	Flagellar rod assembly protein muramidase FlgJ
ET527_RS02390	COG3942	CHAP domain
ET527_RS02395	COG0791	NLP P60 protein
ET527_RS02395	COG1388	LysM domain
ET527_RS02415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ET527_RS02420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET527_RS02425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ET527_RS02505	COG3189	MarR family transcriptional regulator
ET527_RS02515	COG3250	beta-galactosidase activity
ET527_RS02520	COG1609	Transcriptional regulator
ET527_RS02555	COG0395	ABC-type sugar transport system, permease component
ET527_RS02585	COG1216	Glycosyl transferase, family 2
ET527_RS02590	COG0628	permease
ET527_RS02625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ET527_RS02640	COG1946	Acyl-CoA thioesterase
ET527_RS02650	COG0242	peptide deformylase activity
ET527_RS02655	COG2873	o-acetylhomoserine
ET527_RS02690	COG3507	Belongs to the glycosyl hydrolase 43 family
ET527_RS02705	COG1175	transmembrane transport
ET527_RS02715	COG3507	Belongs to the glycosyl hydrolase 43 family
ET527_RS02725	COG2272	Belongs to the type-B carboxylesterase lipase family
ET527_RS02735	COG1070	Carbohydrate kinase
ET527_RS02740	COG1940	carbohydrate kinase activity
ET527_RS02760	COG0009	L-threonylcarbamoyladenylate synthase
ET527_RS02780	COG0561	phosphatase activity
ET527_RS02785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ET527_RS02805	COG3590	peptidase
ET527_RS02815	COG0024	Methionine aminopeptidase
ET527_RS02820	COG0372	Belongs to the citrate synthase family
ET527_RS02840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ET527_RS02845	COG2884	Cell division ATP-binding protein ftsE
ET527_RS02855	COG3942	CHAP domain
ET527_RS02855	COG1388	LysM domain
ET527_RS02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET527_RS02880	COG0765	amino acid transport
ET527_RS02895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET527_RS02895	COG2198	Histidine kinase
ET527_RS02895	COG2205	protein histidine kinase activity
ET527_RS02895	COG0784	Response regulator, receiver
ET527_RS02900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ET527_RS02920	COG0747	negative chemotaxis
ET527_RS02925	COG0601	transmembrane transport
ET527_RS02930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET527_RS02940	COG4172	Belongs to the ABC transporter superfamily
ET527_RS02955	COG0514	ATP-dependent DNA helicase (RecQ)
ET527_RS03035	COG0371	Dehydrogenase
ET527_RS03050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ET527_RS03055	COG0358	DNA primase activity
ET527_RS03060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ET527_RS03070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ET527_RS03075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ET527_RS03080	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ET527_RS03085	COG0735	belongs to the Fur family
ET527_RS03090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ET527_RS03095	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ET527_RS03100	COG0151	Belongs to the GarS family
ET527_RS03115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ET527_RS03170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ET527_RS03250	COG0284	orotidine-5'-phosphate decarboxylase activity
ET527_RS03275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ET527_RS03290	COG0560	Phosphoserine phosphatase
ET527_RS03295	COG0586	Pfam SNARE associated Golgi protein
ET527_RS03305	COG4122	O-methyltransferase activity
ET527_RS03335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ET527_RS03375	COG0714	Associated with various cellular activities
ET527_RS03390	COG1278	Cold shock
ET527_RS03410	COG0745	RESPONSE REGULATOR receiver
ET527_RS03415	COG2205	protein histidine kinase activity
ET527_RS03420	COG1278	Cold shock
ET527_RS03455	COG1196	nuclear chromosome segregation
ET527_RS03465	COG1126	abc transporter atp-binding protein
ET527_RS03470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ET527_RS03475	COG0765	amino acid transport
ET527_RS03480	COG0765	amino acid transport
ET527_RS03485	COG2326	polyphosphate kinase activity
ET527_RS03500	COG2814	Major facilitator Superfamily
ET527_RS03505	COG1022	Amp-dependent synthetase and ligase
ET527_RS03510	COG3328	transposase activity
ET527_RS03535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ET527_RS03545	COG0656	L-ascorbic acid biosynthetic process
ET527_RS03570	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ET527_RS03590	COG0489	protein tyrosine kinase activity
ET527_RS03590	COG2151	metal-sulfur cluster biosynthetic enzyme
ET527_RS03595	COG4721	ABC-type cobalt transport system, permease component
ET527_RS03620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ET527_RS03660	COG4721	ABC-type cobalt transport system, permease component
ET527_RS03665	COG4172	Belongs to the ABC transporter superfamily
ET527_RS03670	COG1136	(ABC) transporter
ET527_RS03675	COG0577	efflux transmembrane transporter activity
ET527_RS03685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ET527_RS03775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ET527_RS03780	COG0569	domain protein
ET527_RS03795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ET527_RS03815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ET527_RS03835	COG0799	negative regulation of ribosome biogenesis
ET527_RS03865	COG0406	alpha-ribazole phosphatase activity
ET527_RS03870	COG0598	Magnesium transport protein CorA
ET527_RS03900	COG0802	atpase or kinase
ET527_RS03955	COG0516	GMP reductase activity
ET527_RS03965	COG1022	Amp-dependent synthetase and ligase
ET527_RS03995	COG0575	Belongs to the CDS family
ET527_RS04035	COG1573	uracil-dna glycosylase
ET527_RS04045	COG0133	tryptophan synthase activity
ET527_RS04060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ET527_RS04075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ET527_RS04095	COG1716	ATPase activity
ET527_RS04110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET527_RS04115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ET527_RS04170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ET527_RS04195	COG0045	succinate-CoA ligase (ADP-forming) activity
ET527_RS04230	COG0438	transferase activity, transferring glycosyl groups
ET527_RS04235	COG1560	Kdo2-lipid A biosynthetic process
ET527_RS04250	COG0488	(ABC) transporter
ET527_RS04260	COG0456	acetyltransferase
ET527_RS04330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ET527_RS04340	COG0436	Aminotransferase
ET527_RS04350	COG0436	Aminotransferase
ET527_RS04355	COG0561	phosphatase activity
ET527_RS04360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ET527_RS04385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ET527_RS04415	COG0488	(ABC) transporter
ET527_RS04440	COG0450	alkyl hydroperoxide reductase
ET527_RS04450	COG0583	DNA-binding transcription factor activity
ET527_RS04490	COG0167	dihydroorotate dehydrogenase activity
ET527_RS04500	COG0284	orotidine-5'-phosphate decarboxylase activity
ET527_RS04505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ET527_RS04525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ET527_RS04545	COG1119	ATPase activity
ET527_RS04550	COG0297	glycogen (starch) synthase activity
ET527_RS04570	COG0069	glutamate synthase activity
ET527_RS04570	COG0067	glutamate synthase
ET527_RS04570	COG0070	glutamate synthase
ET527_RS04590	COG2860	membrane
ET527_RS04595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ET527_RS04620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ET527_RS04645	COG1702	phosphate starvation-inducible protein PhoH
ET527_RS04650	COG0537	adenosine 5'-monophosphoramidase activity
ET527_RS04655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ET527_RS04680	COG2151	metal-sulfur cluster biosynthetic enzyme
ET527_RS04685	COG0822	iron-sulfur transferase activity
ET527_RS04695	COG0396	ATPase activity
ET527_RS04700	COG0719	Fe-S assembly protein
ET527_RS04710	COG1376	ErfK ybiS ycfS ynhG family protein
ET527_RS04725	COG1523	belongs to the glycosyl hydrolase 13 family
ET527_RS04770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ET527_RS04815	COG0588	phosphoglycerate mutase activity
ET527_RS04820	COG1950	PFAM Membrane protein of
ET527_RS04855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ET527_RS04870	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ET527_RS04885	COG1131	(ABC) transporter
ET527_RS04890	COG1725	Transcriptional regulator
ET527_RS04900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ET527_RS04925	COG0563	adenylate kinase activity
ET527_RS04940	COG3039	Transposase
ET527_RS04960	COG0280	phosphate acetyltransferase
ET527_RS04960	COG0857	belongs to the CobB CobQ family
ET527_RS04965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ET527_RS04995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ET527_RS05010	COG0494	nUDIX hydrolase
ET527_RS05020	COG0469	pyruvate kinase activity
ET527_RS05035	COG0237	dephospho-CoA kinase activity
ET527_RS05040	COG0539	negative regulation of cytoplasmic translation
ET527_RS05050	COG0803	Belongs to the bacterial solute-binding protein 9 family
ET527_RS05055	COG1121	(ABC) transporter
ET527_RS05070	COG1329	Transcriptional regulator
ET527_RS05080	COG0745	RESPONSE REGULATOR receiver
ET527_RS05085	COG2205	protein histidine kinase activity
ET527_RS05115	COG1316	TRANSCRIPTIONal
ET527_RS05120	COG1316	TRANSCRIPTIONal
ET527_RS05145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ET527_RS05155	COG1760	l-serine dehydratase
ET527_RS05200	COG1116	anion transmembrane transporter activity
ET527_RS05225	COG1472	Belongs to the glycosyl hydrolase 3 family
ET527_RS05235	COG1966	Carbon starvation protein
ET527_RS05275	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ET527_RS05275	COG1918	ferrous iron import across plasma membrane
ET527_RS05300	COG0363	glucosamine-6-phosphate deaminase activity
ET527_RS05305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ET527_RS05310	COG3340	Belongs to the peptidase S51 family
ET527_RS05315	COG1114	Component of the transport system for branched-chain amino acids
ET527_RS05345	COG2233	PERMEase
ET527_RS05365	COG0012	GTP binding
ET527_RS05370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ET527_RS05380	COG4585	Histidine kinase
ET527_RS05385	COG2197	response regulator
ET527_RS05395	COG1136	(ABC) transporter
ET527_RS05395	COG0577	efflux transmembrane transporter activity
ET527_RS05405	COG1122	ATPase activity
ET527_RS05410	COG2873	o-acetylhomoserine
ET527_RS05440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ET527_RS05505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ET527_RS05510	COG1882	Formate acetyltransferase
ET527_RS05525	COG1473	amidohydrolase
ET527_RS05530	COG2011	ABC-type metal ion transport system permease component
ET527_RS05540	COG1464	Belongs to the NlpA lipoprotein family
ET527_RS05545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ET527_RS05550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ET527_RS05575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ET527_RS05580	COG4975	Glucose uptake
ET527_RS05585	COG1201	RNA secondary structure unwinding
ET527_RS05610	COG0187	DNA topoisomerase II activity
ET527_RS05615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ET527_RS05625	COG0142	geranyltranstransferase activity
ET527_RS05645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ET527_RS05655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ET527_RS05680	COG1396	sequence-specific DNA binding
ET527_RS05690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ET527_RS05710	COG2357	RelA SpoT domain protein
ET527_RS05715	COG0670	Belongs to the BI1 family
ET527_RS05720	COG3804	dihydrodipicolinate reductase
ET527_RS05735	COG1131	(ABC) transporter
ET527_RS05740	COG4585	Histidine kinase
ET527_RS05745	COG2197	response regulator
ET527_RS05760	COG0366	Alpha amylase catalytic
ET527_RS05765	COG2182	Extracellular solute-binding protein
ET527_RS05780	COG0110	maltose O-acetyltransferase activity
ET527_RS05790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ET527_RS05820	COG0708	Exodeoxyribonuclease III
ET527_RS05835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ET527_RS05840	COG0601	transmembrane transport
ET527_RS05845	COG4166	transmembrane transport
ET527_RS05855	COG1136	(ABC) transporter
ET527_RS05860	COG0577	efflux transmembrane transporter activity
ET527_RS05870	COG0287	Prephenate dehydrogenase
ET527_RS05885	COG1217	gtp-binding protein TYPA
ET527_RS05890	COG0477	Major facilitator Superfamily
ET527_RS05920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ET527_RS05935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ET527_RS05945	COG2017	converts alpha-aldose to the beta-anomer
ET527_RS05970	COG0285	dihydrofolate synthase activity
ET527_RS05990	COG0006	proline dipeptidase activity
ET527_RS05995	COG2816	NAD+ diphosphatase activity
ET527_RS06015	COG0582	viral genome integration into host DNA
ET527_RS06100	COG0601	transmembrane transport
ET527_RS06140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ET527_RS06150	COG0768	penicillin binding
ET527_RS06175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ET527_RS06195	COG1230	cation diffusion facilitator family transporter
ET527_RS06205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ET527_RS06215	COG1643	Atp-dependent helicase
ET527_RS06260	COG0587	DNA-directed DNA polymerase activity
ET527_RS06295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ET527_RS06345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ET527_RS06350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ET527_RS06355	COG1957	nucleoside hydrolase
ET527_RS06405	COG3480	Lon protease (S16) C-terminal proteolytic domain
ET527_RS06430	COG0613	PHP domain protein
ET527_RS06440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ET527_RS06465	COG1126	abc transporter atp-binding protein
ET527_RS06470	COG0765	amino acid transport
ET527_RS06475	COG0765	amino acid transport
ET527_RS06480	COG0436	Aminotransferase
ET527_RS06490	COG2011	ABC-type metal ion transport system permease component
ET527_RS06500	COG1464	Belongs to the NlpA lipoprotein family
ET527_RS06505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ET527_RS06570	COG4166	transmembrane transport
ET527_RS06575	COG2814	Major facilitator Superfamily
ET527_RS06580	COG1842	Phage shock protein A
ET527_RS06605	COG2365	Tyrosine phosphatase family
ET527_RS06620	COG1132	(ABC) transporter
ET527_RS06625	COG1132	(ABC) transporter
ET527_RS06680	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ET527_RS06685	COG1518	maintenance of DNA repeat elements
ET527_RS06685	COG1468	defense response to virus
ET527_RS06720	COG1328	CTP reductase activity
ET527_RS06720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ET527_RS06725	COG1570	exodeoxyribonuclease VII activity
ET527_RS06730	COG1722	exodeoxyribonuclease VII activity
ET527_RS06750	COG0436	Aminotransferase
ET527_RS06785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ET527_RS06810	COG0210	DNA helicase
ET527_RS06830	COG0714	Associated with various cellular activities
ET527_RS06870	COG1194	a g-specific adenine glycosylase
ET527_RS06875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ET527_RS06895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ET527_RS06905	COG1349	DNA-binding transcription factor activity
ET527_RS06910	COG1216	Glycosyl transferase, family 2
ET527_RS06915	COG0167	dihydroorotate dehydrogenase activity
ET527_RS06920	COG1902	pentaerythritol trinitrate reductase activity
ET527_RS06925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ET527_RS06925	COG4499	WXG100 protein secretion system (Wss), protein YukC
ET527_RS06935	COG0095	Lipoate-protein ligase
ET527_RS06980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ET527_RS07015	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ET527_RS07025	COG1088	dTDP-glucose 4,6-dehydratase activity
ET527_RS07045	COG1216	Glycosyl transferase, family 2
ET527_RS07045	COG1442	glycosyl transferase family 8
ET527_RS07095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ET527_RS07105	COG2814	Major facilitator Superfamily
ET527_RS07160	COG4988	ABC transporter
ET527_RS07175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ET527_RS07185	COG0489	protein tyrosine kinase activity
ET527_RS07205	COG0083	homoserine kinase activity
ET527_RS07210	COG0460	homoserine dehydrogenase
ET527_RS07215	COG0019	diaminopimelate decarboxylase activity
ET527_RS07230	COG0251	oxidation-reduction process
ET527_RS07235	COG0395	ABC-type sugar transport system, permease component
ET527_RS07240	COG3459	Glycosyltransferase 36 associated
ET527_RS07265	COG0545	Peptidyl-prolyl cis-trans isomerase
ET527_RS07275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ET527_RS07310	COG0356	it plays a direct role in the translocation of protons across the membrane
ET527_RS07320	COG0477	Major facilitator Superfamily
ET527_RS07375	COG0582	viral genome integration into host DNA
ET527_RS07395	COG0679	Auxin Efflux Carrier
ET527_RS07400	COG0028	Belongs to the TPP enzyme family
ET527_RS07425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ET527_RS07435	COG0745	RESPONSE REGULATOR receiver
ET527_RS07445	COG0747	negative chemotaxis
ET527_RS07460	COG1605	Chorismate mutase
ET527_RS07460	COG0287	Prephenate dehydrogenase
ET527_RS07525	COG2217	Heavy metal translocating P-type atpase
ET527_RS07535	COG0179	Fumarylacetoacetate (FAA) hydrolase
ET527_RS07560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ET527_RS07575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ET527_RS07630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ET527_RS07645	COG1609	Transcriptional regulator
ET527_RS07690	COG1368	sulfuric ester hydrolase activity
ET527_RS07700	COG1368	sulfuric ester hydrolase activity
ET527_RS07705	COG1216	Glycosyl transferase, family 2
ET527_RS07755	COG1216	Glycosyl transferase, family 2
ET527_RS07810	COG0084	hydrolase, TatD family'
ET527_RS07825	COG1132	(ABC) transporter
ET527_RS07830	COG1132	(ABC) transporter
ET527_RS07870	COG0586	Pfam SNARE associated Golgi protein
ET527_RS07890	COG1309	transcriptional regulator
ET527_RS07895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ET527_RS07900	COG0789	Transcriptional regulator
ET527_RS07905	COG0484	heat shock protein binding
ET527_RS07935	COG1523	belongs to the glycosyl hydrolase 13 family
ET527_RS07940	COG3833	ABC-type maltose transport systems, permease component
ET527_RS07945	COG1175	transmembrane transport
ET527_RS07955	COG0366	Alpha amylase catalytic
ET527_RS07980	COG1609	Transcriptional regulator
ET527_RS07990	COG0366	Alpha amylase catalytic
ET527_RS08025	COG1609	Transcriptional regulator
ET527_RS08030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ET527_RS08035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ET527_RS08040	COG0366	Alpha amylase catalytic
ET527_RS08060	COG0395	ABC-type sugar transport system, permease component
ET527_RS08065	COG1175	transmembrane transport
ET527_RS08085	COG0590	tRNA wobble adenosine to inosine editing
ET527_RS08085	COG0037	tRNA processing
ET527_RS08090	COG0025	NhaP-type Na H and K H
ET527_RS08110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ET527_RS08120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ET527_RS08130	COG3842	ATPase activity
ET527_RS08135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ET527_RS08155	COG3583	domain protein
ET527_RS08175	COG0617	tRNA 3'-terminal CCA addition
ET527_RS08195	COG0492	ferredoxin-NADP+ reductase activity
ET527_RS08200	COG1475	DNA binding
ET527_RS08205	COG1192	Involved in chromosome partitioning
ET527_RS08215	COG1847	R3H domain protein