locus-tag	class	description
BGL50_RS00010	COG0592	DNA-directed DNA polymerase activity
BGL50_RS00025	COG0187	DNA topoisomerase II activity
BGL50_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BGL50_RS00045	COG1272	protein, Hemolysin III
BGL50_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BGL50_RS00055	COG2814	Major facilitator Superfamily
BGL50_RS00070	COG1970	mechanosensitive ion channel activity
BGL50_RS00115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BGL50_RS00120	COG2226	methyltransferase
BGL50_RS00230	COG0583	DNA-binding transcription factor activity
BGL50_RS00245	COG3231	kanamycin kinase activity
BGL50_RS00285	COG0783	Belongs to the Dps family
BGL50_RS00290	COG1253	flavin adenine dinucleotide binding
BGL50_RS00295	COG0288	reversible hydration of carbon dioxide
BGL50_RS00300	COG1609	Transcriptional regulator
BGL50_RS00320	COG1609	Transcriptional regulator
BGL50_RS00325	COG3534	alpha-L-arabinofuranosidase
BGL50_RS00345	COG0656	L-ascorbic acid biosynthetic process
BGL50_RS00350	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BGL50_RS00365	COG0180	Tryptophanyl-tRNA synthetase
BGL50_RS00380	COG0058	SHG alpha-glucan phosphorylase activity
BGL50_RS00420	COG3764	Sortase (surface protein transpeptidase)
BGL50_RS00435	COG0515	serine threonine protein kinase
BGL50_RS00440	COG0768	penicillin binding
BGL50_RS00475	COG0697	spore germination
BGL50_RS00490	COG2226	methyltransferase
BGL50_RS00500	COG2261	transglycosylase associated protein
BGL50_RS00505	COG2261	transglycosylase associated protein
BGL50_RS00530	COG2217	Heavy metal translocating P-type atpase
BGL50_RS00535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BGL50_RS00550	COG0343	queuine tRNA-ribosyltransferase activity
BGL50_RS00575	COG2814	Major facilitator Superfamily
BGL50_RS00590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BGL50_RS00620	COG0667	Aldo Keto reductase
BGL50_RS00655	COG1063	alcohol dehydrogenase
BGL50_RS00660	COG0583	DNA-binding transcription factor activity
BGL50_RS00670	COG0191	fructose-bisphosphate aldolase activity
BGL50_RS00680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BGL50_RS00730	COG2211	Major facilitator Superfamily
BGL50_RS00740	COG4770	biotin carboxylase activity
BGL50_RS00770	COG0477	Major facilitator Superfamily
BGL50_RS00825	COG1132	(ABC) transporter
BGL50_RS00830	COG0390	transport system, permease component
BGL50_RS00835	COG1113	amino acid transport
BGL50_RS00840	COG1136	(ABC) transporter
BGL50_RS00840	COG0577	efflux transmembrane transporter activity
BGL50_RS00850	COG1113	amino acid transport
BGL50_RS00865	COG0577	efflux transmembrane transporter activity
BGL50_RS00870	COG0577	efflux transmembrane transporter activity
BGL50_RS00870	COG1136	(ABC) transporter
BGL50_RS00880	COG1846	Transcriptional regulator
BGL50_RS00900	COG0671	phosphoesterase, PA-phosphatase related
BGL50_RS00905	COG0110	maltose O-acetyltransferase activity
BGL50_RS00950	COG1129	ABC transporter
BGL50_RS00985	COG1309	transcriptional regulator
BGL50_RS01005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BGL50_RS01015	COG0305	Participates in initiation and elongation during chromosome replication
BGL50_RS01020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BGL50_RS01055	COG0406	alpha-ribazole phosphatase activity
BGL50_RS01055	COG0494	nUDIX hydrolase
BGL50_RS01150	COG1260	myo-inositol-1-phosphate synthase
BGL50_RS01165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BGL50_RS01165	COG1754	DNA topoisomerase type I activity
BGL50_RS01230	COG0406	alpha-ribazole phosphatase activity
BGL50_RS01290	COG0446	pyridine nucleotide-disulphide oxidoreductase
BGL50_RS01300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BGL50_RS01355	COG0436	Aminotransferase
BGL50_RS01370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BGL50_RS01370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BGL50_RS01380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BGL50_RS01395	COG0742	ribosomal rna small subunit methyltransferase
BGL50_RS01410	COG1837	Belongs to the UPF0109 family
BGL50_RS01450	COG0488	(ABC) transporter
BGL50_RS01460	COG0440	acetolactate synthase activity
BGL50_RS01500	COG0667	Aldo Keto reductase
BGL50_RS01570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BGL50_RS01590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BGL50_RS01595	COG1530	ribonuclease E activity
BGL50_RS01635	COG0436	Aminotransferase
BGL50_RS01670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BGL50_RS01670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BGL50_RS01675	COG1268	BioY protein
BGL50_RS01680	COG4770	biotin carboxylase activity
BGL50_RS01685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BGL50_RS01710	COG0039	L-malate dehydrogenase activity
BGL50_RS01725	COG1704	LemA family
BGL50_RS01735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BGL50_RS01740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BGL50_RS01760	COG0826	peptidase U32
BGL50_RS01780	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BGL50_RS01790	COG3579	cysteine-type endopeptidase activity
BGL50_RS01795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BGL50_RS01800	COG2755	lipolytic protein G-D-S-L family
BGL50_RS01800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BGL50_RS01805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BGL50_RS01810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BGL50_RS01820	COG0745	RESPONSE REGULATOR receiver
BGL50_RS01835	COG0581	inorganic phosphate transmembrane transporter activity
BGL50_RS01845	COG2252	PERMEase
BGL50_RS01930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BGL50_RS01935	COG0531	amino acid
BGL50_RS01950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BGL50_RS01960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BGL50_RS01965	COG1739	Uncharacterized protein family UPF0029
BGL50_RS02000	COG1454	alcohol dehydrogenase
BGL50_RS02000	COG1012	belongs to the aldehyde dehydrogenase family
BGL50_RS02060	COG0255	Belongs to the universal ribosomal protein uL29 family
BGL50_RS02195	COG0196	riboflavin kinase activity
BGL50_RS02220	COG0328	RNA-DNA hybrid ribonuclease activity
BGL50_RS02240	COG1597	lipid kinase activity
BGL50_RS02240	COG1803	Methylglyoxal synthase
BGL50_RS02265	COG2197	response regulator
BGL50_RS02285	COG0626	cystathionine gamma-synthase activity
BGL50_RS02295	COG2873	o-acetylhomoserine
BGL50_RS02305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BGL50_RS02320	COG3579	cysteine-type endopeptidase activity
BGL50_RS02325	COG0531	amino acid
BGL50_RS02335	COG1113	amino acid transport
BGL50_RS02350	COG4716	Myosin-crossreactive antigen
BGL50_RS02355	COG1063	alcohol dehydrogenase
BGL50_RS02360	COG3321	synthase
BGL50_RS02360	COG1028	Short-chain dehydrogenase reductase Sdr
BGL50_RS02360	COG0604	alcohol dehydrogenase
BGL50_RS02370	COG5002	protein histidine kinase activity
BGL50_RS02375	COG0704	Plays a role in the regulation of phosphate uptake
BGL50_RS02380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BGL50_RS02385	COG3942	CHAP domain
BGL50_RS02385	COG1705	Flagellar rod assembly protein muramidase FlgJ
BGL50_RS02390	COG0791	NLP P60 protein
BGL50_RS02390	COG1388	LysM domain
BGL50_RS02410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BGL50_RS02415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BGL50_RS02420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BGL50_RS02500	COG3189	MarR family transcriptional regulator
BGL50_RS02510	COG3250	beta-galactosidase activity
BGL50_RS02515	COG1609	Transcriptional regulator
BGL50_RS02550	COG0395	ABC-type sugar transport system, permease component
BGL50_RS02580	COG1216	Glycosyl transferase, family 2
BGL50_RS02585	COG0628	permease
BGL50_RS02620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BGL50_RS02635	COG1946	Acyl-CoA thioesterase
BGL50_RS02645	COG0242	peptide deformylase activity
BGL50_RS02650	COG2873	o-acetylhomoserine
BGL50_RS02685	COG3507	Belongs to the glycosyl hydrolase 43 family
BGL50_RS02700	COG1175	transmembrane transport
BGL50_RS02710	COG3507	Belongs to the glycosyl hydrolase 43 family
BGL50_RS02720	COG2272	Belongs to the type-B carboxylesterase lipase family
BGL50_RS02730	COG1070	Carbohydrate kinase
BGL50_RS02735	COG1940	carbohydrate kinase activity
BGL50_RS02755	COG0009	L-threonylcarbamoyladenylate synthase
BGL50_RS02775	COG0561	phosphatase activity
BGL50_RS02780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BGL50_RS02800	COG3590	peptidase
BGL50_RS02810	COG0024	Methionine aminopeptidase
BGL50_RS02815	COG0372	Belongs to the citrate synthase family
BGL50_RS02835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BGL50_RS02840	COG2884	Cell division ATP-binding protein ftsE
BGL50_RS02850	COG3942	CHAP domain
BGL50_RS02850	COG1388	LysM domain
BGL50_RS02870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BGL50_RS02875	COG0765	amino acid transport
BGL50_RS02890	COG2205	protein histidine kinase activity
BGL50_RS02890	COG0784	Response regulator, receiver
BGL50_RS02890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BGL50_RS02890	COG2198	Histidine kinase
BGL50_RS02895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BGL50_RS02915	COG0747	negative chemotaxis
BGL50_RS02920	COG0601	transmembrane transport
BGL50_RS02925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BGL50_RS02935	COG4172	Belongs to the ABC transporter superfamily
BGL50_RS02950	COG0514	ATP-dependent DNA helicase (RecQ)
BGL50_RS03030	COG0371	Dehydrogenase
BGL50_RS03045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BGL50_RS03050	COG0358	DNA primase activity
BGL50_RS03055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BGL50_RS03065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BGL50_RS03070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BGL50_RS03075	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BGL50_RS03080	COG0735	belongs to the Fur family
BGL50_RS03085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BGL50_RS03090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BGL50_RS03095	COG0151	Belongs to the GarS family
BGL50_RS03110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BGL50_RS03165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BGL50_RS03245	COG0284	orotidine-5'-phosphate decarboxylase activity
BGL50_RS03270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BGL50_RS03285	COG0560	Phosphoserine phosphatase
BGL50_RS03290	COG0586	Pfam SNARE associated Golgi protein
BGL50_RS03300	COG4122	O-methyltransferase activity
BGL50_RS03330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BGL50_RS03370	COG0714	Associated with various cellular activities
BGL50_RS03385	COG1278	Cold shock
BGL50_RS03405	COG0745	RESPONSE REGULATOR receiver
BGL50_RS03410	COG2205	protein histidine kinase activity
BGL50_RS03415	COG1278	Cold shock
BGL50_RS03450	COG1196	nuclear chromosome segregation
BGL50_RS03460	COG1126	abc transporter atp-binding protein
BGL50_RS03465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BGL50_RS03470	COG0765	amino acid transport
BGL50_RS03475	COG0765	amino acid transport
BGL50_RS03480	COG2326	polyphosphate kinase activity
BGL50_RS03495	COG2814	Major facilitator Superfamily
BGL50_RS03500	COG1022	Amp-dependent synthetase and ligase
BGL50_RS03505	COG3328	transposase activity
BGL50_RS03530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BGL50_RS03540	COG0656	L-ascorbic acid biosynthetic process
BGL50_RS03565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BGL50_RS03585	COG0489	protein tyrosine kinase activity
BGL50_RS03585	COG2151	metal-sulfur cluster biosynthetic enzyme
BGL50_RS03590	COG4721	ABC-type cobalt transport system, permease component
BGL50_RS03615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BGL50_RS03650	COG4721	ABC-type cobalt transport system, permease component
BGL50_RS03655	COG4172	Belongs to the ABC transporter superfamily
BGL50_RS03660	COG1136	(ABC) transporter
BGL50_RS03665	COG0577	efflux transmembrane transporter activity
BGL50_RS03675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BGL50_RS03765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BGL50_RS03770	COG0569	domain protein
BGL50_RS03785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BGL50_RS03805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BGL50_RS03825	COG0799	negative regulation of ribosome biogenesis
BGL50_RS03855	COG0406	alpha-ribazole phosphatase activity
BGL50_RS03860	COG0598	Magnesium transport protein CorA
BGL50_RS03890	COG0802	atpase or kinase
BGL50_RS03950	COG0516	GMP reductase activity
BGL50_RS03960	COG1022	Amp-dependent synthetase and ligase
BGL50_RS03990	COG0575	Belongs to the CDS family
BGL50_RS04030	COG1573	uracil-dna glycosylase
BGL50_RS04040	COG0133	tryptophan synthase activity
BGL50_RS04055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BGL50_RS04070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BGL50_RS04090	COG1716	ATPase activity
BGL50_RS04105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BGL50_RS04110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BGL50_RS04165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BGL50_RS04190	COG0045	succinate-CoA ligase (ADP-forming) activity
BGL50_RS04225	COG0438	transferase activity, transferring glycosyl groups
BGL50_RS04230	COG1560	Kdo2-lipid A biosynthetic process
BGL50_RS04245	COG0488	(ABC) transporter
BGL50_RS04255	COG0456	acetyltransferase
BGL50_RS04325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BGL50_RS04335	COG0436	Aminotransferase
BGL50_RS04345	COG0436	Aminotransferase
BGL50_RS04350	COG0561	phosphatase activity
BGL50_RS04355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BGL50_RS04380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BGL50_RS04410	COG0488	(ABC) transporter
BGL50_RS04435	COG0450	alkyl hydroperoxide reductase
BGL50_RS04445	COG0583	DNA-binding transcription factor activity
BGL50_RS04485	COG0167	dihydroorotate dehydrogenase activity
BGL50_RS04495	COG0284	orotidine-5'-phosphate decarboxylase activity
BGL50_RS04500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BGL50_RS04520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BGL50_RS04540	COG1119	ATPase activity
BGL50_RS04545	COG0297	glycogen (starch) synthase activity
BGL50_RS04565	COG0067	glutamate synthase
BGL50_RS04565	COG0070	glutamate synthase
BGL50_RS04565	COG0069	glutamate synthase activity
BGL50_RS04585	COG2860	membrane
BGL50_RS04615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BGL50_RS04640	COG1702	phosphate starvation-inducible protein PhoH
BGL50_RS04645	COG0537	adenosine 5'-monophosphoramidase activity
BGL50_RS04650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BGL50_RS04675	COG2151	metal-sulfur cluster biosynthetic enzyme
BGL50_RS04680	COG0822	iron-sulfur transferase activity
BGL50_RS04690	COG0396	ATPase activity
BGL50_RS04695	COG0719	Fe-S assembly protein
BGL50_RS04705	COG1376	ErfK ybiS ycfS ynhG family protein
BGL50_RS04720	COG1523	belongs to the glycosyl hydrolase 13 family
BGL50_RS04765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BGL50_RS04810	COG0588	phosphoglycerate mutase activity
BGL50_RS04815	COG1950	PFAM Membrane protein of
BGL50_RS04850	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BGL50_RS04865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BGL50_RS04880	COG1131	(ABC) transporter
BGL50_RS04885	COG1725	Transcriptional regulator
BGL50_RS04895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BGL50_RS04920	COG0563	adenylate kinase activity
BGL50_RS04940	COG3039	Transposase
BGL50_RS04960	COG0857	belongs to the CobB CobQ family
BGL50_RS04960	COG0280	phosphate acetyltransferase
BGL50_RS04965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BGL50_RS04995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BGL50_RS05010	COG0494	nUDIX hydrolase
BGL50_RS05020	COG0469	pyruvate kinase activity
BGL50_RS05035	COG0237	dephospho-CoA kinase activity
BGL50_RS05040	COG0539	negative regulation of cytoplasmic translation
BGL50_RS05050	COG0803	Belongs to the bacterial solute-binding protein 9 family
BGL50_RS05055	COG1121	(ABC) transporter
BGL50_RS05070	COG1329	Transcriptional regulator
BGL50_RS05080	COG0745	RESPONSE REGULATOR receiver
BGL50_RS05085	COG2205	protein histidine kinase activity
BGL50_RS05115	COG1316	TRANSCRIPTIONal
BGL50_RS05120	COG1316	TRANSCRIPTIONal
BGL50_RS05145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BGL50_RS05155	COG1760	l-serine dehydratase
BGL50_RS05200	COG1116	anion transmembrane transporter activity
BGL50_RS05225	COG1472	Belongs to the glycosyl hydrolase 3 family
BGL50_RS05235	COG1966	Carbon starvation protein
BGL50_RS05275	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BGL50_RS05275	COG1918	ferrous iron import across plasma membrane
BGL50_RS05300	COG0363	glucosamine-6-phosphate deaminase activity
BGL50_RS05305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BGL50_RS05310	COG3340	Belongs to the peptidase S51 family
BGL50_RS05315	COG1114	Component of the transport system for branched-chain amino acids
BGL50_RS05345	COG2233	PERMEase
BGL50_RS05365	COG0012	GTP binding
BGL50_RS05370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BGL50_RS05380	COG4585	Histidine kinase
BGL50_RS05385	COG2197	response regulator
BGL50_RS05395	COG1136	(ABC) transporter
BGL50_RS05395	COG0577	efflux transmembrane transporter activity
BGL50_RS05405	COG1122	ATPase activity
BGL50_RS05410	COG2873	o-acetylhomoserine
BGL50_RS05440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BGL50_RS05505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BGL50_RS05510	COG1882	Formate acetyltransferase
BGL50_RS05525	COG1473	amidohydrolase
BGL50_RS05530	COG2011	ABC-type metal ion transport system permease component
BGL50_RS05540	COG1464	Belongs to the NlpA lipoprotein family
BGL50_RS05545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BGL50_RS05550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BGL50_RS05575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BGL50_RS05580	COG4975	Glucose uptake
BGL50_RS05585	COG1201	RNA secondary structure unwinding
BGL50_RS05605	COG0438	transferase activity, transferring glycosyl groups
BGL50_RS05610	COG0187	DNA topoisomerase II activity
BGL50_RS05615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BGL50_RS05625	COG0142	geranyltranstransferase activity
BGL50_RS05645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BGL50_RS05655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BGL50_RS05680	COG1396	sequence-specific DNA binding
BGL50_RS05690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BGL50_RS05710	COG2357	RelA SpoT domain protein
BGL50_RS05715	COG0670	Belongs to the BI1 family
BGL50_RS05720	COG3804	dihydrodipicolinate reductase
BGL50_RS05735	COG1131	(ABC) transporter
BGL50_RS05740	COG4585	Histidine kinase
BGL50_RS05745	COG2197	response regulator
BGL50_RS05760	COG0366	Alpha amylase catalytic
BGL50_RS05765	COG2182	Extracellular solute-binding protein
BGL50_RS05780	COG0110	maltose O-acetyltransferase activity
BGL50_RS05790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BGL50_RS05820	COG0708	Exodeoxyribonuclease III
BGL50_RS05835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BGL50_RS05840	COG0601	transmembrane transport
BGL50_RS05845	COG4166	transmembrane transport
BGL50_RS05855	COG1136	(ABC) transporter
BGL50_RS05860	COG0577	efflux transmembrane transporter activity
BGL50_RS05870	COG0287	Prephenate dehydrogenase
BGL50_RS05885	COG1217	gtp-binding protein TYPA
BGL50_RS05890	COG0477	Major facilitator Superfamily
BGL50_RS05920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BGL50_RS05935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BGL50_RS05945	COG2017	converts alpha-aldose to the beta-anomer
BGL50_RS05970	COG0285	dihydrofolate synthase activity
BGL50_RS05990	COG0006	proline dipeptidase activity
BGL50_RS05995	COG2816	NAD+ diphosphatase activity
BGL50_RS06015	COG0582	viral genome integration into host DNA
BGL50_RS06100	COG0601	transmembrane transport
BGL50_RS06140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BGL50_RS06150	COG0768	penicillin binding
BGL50_RS06175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BGL50_RS06195	COG1230	cation diffusion facilitator family transporter
BGL50_RS06205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BGL50_RS06215	COG1643	Atp-dependent helicase
BGL50_RS06260	COG0587	DNA-directed DNA polymerase activity
BGL50_RS06295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BGL50_RS06345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BGL50_RS06350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BGL50_RS06355	COG1957	nucleoside hydrolase
BGL50_RS06410	COG3480	Lon protease (S16) C-terminal proteolytic domain
BGL50_RS06435	COG0613	PHP domain protein
BGL50_RS06445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BGL50_RS06470	COG1126	abc transporter atp-binding protein
BGL50_RS06475	COG0765	amino acid transport
BGL50_RS06480	COG0765	amino acid transport
BGL50_RS06485	COG0436	Aminotransferase
BGL50_RS06495	COG2011	ABC-type metal ion transport system permease component
BGL50_RS06505	COG1464	Belongs to the NlpA lipoprotein family
BGL50_RS06510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BGL50_RS06580	COG2814	Major facilitator Superfamily
BGL50_RS06585	COG1842	Phage shock protein A
BGL50_RS06605	COG2365	Tyrosine phosphatase family
BGL50_RS06620	COG1132	(ABC) transporter
BGL50_RS06625	COG1132	(ABC) transporter
BGL50_RS06680	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BGL50_RS06685	COG1518	maintenance of DNA repeat elements
BGL50_RS06685	COG1468	defense response to virus
BGL50_RS06720	COG1328	CTP reductase activity
BGL50_RS06720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BGL50_RS06725	COG1570	exodeoxyribonuclease VII activity
BGL50_RS06730	COG1722	exodeoxyribonuclease VII activity
BGL50_RS06750	COG0436	Aminotransferase
BGL50_RS06785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BGL50_RS06810	COG0210	DNA helicase
BGL50_RS06830	COG0714	Associated with various cellular activities
BGL50_RS06870	COG1194	a g-specific adenine glycosylase
BGL50_RS06875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BGL50_RS06895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BGL50_RS06905	COG1349	DNA-binding transcription factor activity
BGL50_RS06910	COG1216	Glycosyl transferase, family 2
BGL50_RS06915	COG0167	dihydroorotate dehydrogenase activity
BGL50_RS06920	COG1902	pentaerythritol trinitrate reductase activity
BGL50_RS06925	COG4499	WXG100 protein secretion system (Wss), protein YukC
BGL50_RS06925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BGL50_RS06935	COG0095	Lipoate-protein ligase
BGL50_RS06980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BGL50_RS07015	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BGL50_RS07025	COG1088	dTDP-glucose 4,6-dehydratase activity
BGL50_RS07045	COG1216	Glycosyl transferase, family 2
BGL50_RS07045	COG1442	glycosyl transferase family 8
BGL50_RS07095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BGL50_RS07105	COG2814	Major facilitator Superfamily
BGL50_RS07160	COG4988	ABC transporter
BGL50_RS07175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BGL50_RS07185	COG0489	protein tyrosine kinase activity
BGL50_RS07205	COG0083	homoserine kinase activity
BGL50_RS07210	COG0460	homoserine dehydrogenase
BGL50_RS07215	COG0019	diaminopimelate decarboxylase activity
BGL50_RS07230	COG0251	oxidation-reduction process
BGL50_RS07235	COG0395	ABC-type sugar transport system, permease component
BGL50_RS07240	COG3459	Glycosyltransferase 36 associated
BGL50_RS07265	COG0545	Peptidyl-prolyl cis-trans isomerase
BGL50_RS07275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BGL50_RS07310	COG0356	it plays a direct role in the translocation of protons across the membrane
BGL50_RS07320	COG0477	Major facilitator Superfamily
BGL50_RS07375	COG0582	viral genome integration into host DNA
BGL50_RS07395	COG0679	Auxin Efflux Carrier
BGL50_RS07425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BGL50_RS07435	COG0745	RESPONSE REGULATOR receiver
BGL50_RS07445	COG0747	negative chemotaxis
BGL50_RS07460	COG1605	Chorismate mutase
BGL50_RS07460	COG0287	Prephenate dehydrogenase
BGL50_RS07525	COG2217	Heavy metal translocating P-type atpase
BGL50_RS07535	COG0179	Fumarylacetoacetate (FAA) hydrolase
BGL50_RS07560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BGL50_RS07575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BGL50_RS07625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BGL50_RS07640	COG1609	Transcriptional regulator
BGL50_RS07685	COG1368	sulfuric ester hydrolase activity
BGL50_RS07695	COG1368	sulfuric ester hydrolase activity
BGL50_RS07700	COG1216	Glycosyl transferase, family 2
BGL50_RS07750	COG1216	Glycosyl transferase, family 2
BGL50_RS07805	COG0084	hydrolase, TatD family'
BGL50_RS07820	COG1132	(ABC) transporter
BGL50_RS07825	COG1132	(ABC) transporter
BGL50_RS07865	COG0586	Pfam SNARE associated Golgi protein
BGL50_RS07885	COG1309	transcriptional regulator
BGL50_RS07890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BGL50_RS07895	COG0789	Transcriptional regulator
BGL50_RS07900	COG0484	heat shock protein binding
BGL50_RS07930	COG1523	belongs to the glycosyl hydrolase 13 family
BGL50_RS07935	COG3833	ABC-type maltose transport systems, permease component
BGL50_RS07940	COG1175	transmembrane transport
BGL50_RS07950	COG0366	Alpha amylase catalytic
BGL50_RS07975	COG1609	Transcriptional regulator
BGL50_RS07985	COG0366	Alpha amylase catalytic
BGL50_RS08000	COG0778	Nitroreductase
BGL50_RS08010	COG2814	Major facilitator Superfamily
BGL50_RS08085	COG1609	Transcriptional regulator
BGL50_RS08090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BGL50_RS08095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BGL50_RS08100	COG0366	Alpha amylase catalytic
BGL50_RS08120	COG0395	ABC-type sugar transport system, permease component
BGL50_RS08125	COG1175	transmembrane transport
BGL50_RS08145	COG0590	tRNA wobble adenosine to inosine editing
BGL50_RS08145	COG0037	tRNA processing
BGL50_RS08150	COG0025	NhaP-type Na H and K H
BGL50_RS08170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BGL50_RS08180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BGL50_RS08190	COG3842	ATPase activity
BGL50_RS08195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BGL50_RS08215	COG3583	domain protein
BGL50_RS08235	COG0617	tRNA 3'-terminal CCA addition
BGL50_RS08255	COG0492	ferredoxin-NADP+ reductase activity
BGL50_RS08260	COG1475	DNA binding
BGL50_RS08265	COG1192	Involved in chromosome partitioning
BGL50_RS08275	COG1847	R3H domain protein