locus-tag	class	description
GFB60_RS00010	COG0592	DNA-directed DNA polymerase activity
GFB60_RS00025	COG0187	DNA topoisomerase II activity
GFB60_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFB60_RS00045	COG1272	protein, Hemolysin III
GFB60_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFB60_RS00055	COG2814	Major facilitator Superfamily
GFB60_RS00070	COG1970	mechanosensitive ion channel activity
GFB60_RS00110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFB60_RS00115	COG2226	methyltransferase
GFB60_RS00220	COG0583	DNA-binding transcription factor activity
GFB60_RS00235	COG3231	kanamycin kinase activity
GFB60_RS00275	COG0783	Belongs to the Dps family
GFB60_RS00280	COG1253	flavin adenine dinucleotide binding
GFB60_RS00285	COG0288	reversible hydration of carbon dioxide
GFB60_RS00290	COG1609	Transcriptional regulator
GFB60_RS00310	COG1609	Transcriptional regulator
GFB60_RS00315	COG3534	alpha-L-arabinofuranosidase
GFB60_RS00335	COG0656	L-ascorbic acid biosynthetic process
GFB60_RS00340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GFB60_RS00355	COG0180	Tryptophanyl-tRNA synthetase
GFB60_RS00370	COG0058	SHG alpha-glucan phosphorylase activity
GFB60_RS00400	COG3764	Sortase (surface protein transpeptidase)
GFB60_RS00415	COG0515	serine threonine protein kinase
GFB60_RS00420	COG0768	penicillin binding
GFB60_RS00450	COG0697	spore germination
GFB60_RS00465	COG2226	methyltransferase
GFB60_RS00470	COG2261	transglycosylase associated protein
GFB60_RS00475	COG2261	transglycosylase associated protein
GFB60_RS00490	COG2217	Heavy metal translocating P-type atpase
GFB60_RS00495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFB60_RS00510	COG0343	queuine tRNA-ribosyltransferase activity
GFB60_RS00535	COG2814	Major facilitator Superfamily
GFB60_RS00550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFB60_RS00580	COG0667	Aldo Keto reductase
GFB60_RS00615	COG1063	alcohol dehydrogenase
GFB60_RS00620	COG0583	DNA-binding transcription factor activity
GFB60_RS00630	COG0191	fructose-bisphosphate aldolase activity
GFB60_RS00640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFB60_RS00685	COG2211	Major facilitator Superfamily
GFB60_RS00695	COG4770	biotin carboxylase activity
GFB60_RS00730	COG0477	Major facilitator Superfamily
GFB60_RS00785	COG1132	(ABC) transporter
GFB60_RS00790	COG0390	transport system, permease component
GFB60_RS00795	COG1113	amino acid transport
GFB60_RS00800	COG0577	efflux transmembrane transporter activity
GFB60_RS00800	COG1136	(ABC) transporter
GFB60_RS00810	COG1113	amino acid transport
GFB60_RS00825	COG0577	efflux transmembrane transporter activity
GFB60_RS00830	COG0577	efflux transmembrane transporter activity
GFB60_RS00830	COG1136	(ABC) transporter
GFB60_RS00835	COG1846	Transcriptional regulator
GFB60_RS00855	COG0671	phosphoesterase, PA-phosphatase related
GFB60_RS00860	COG0110	maltose O-acetyltransferase activity
GFB60_RS00900	COG1129	ABC transporter
GFB60_RS00935	COG1309	transcriptional regulator
GFB60_RS00955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GFB60_RS00965	COG0305	Participates in initiation and elongation during chromosome replication
GFB60_RS00970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFB60_RS01005	COG0406	alpha-ribazole phosphatase activity
GFB60_RS01005	COG0494	nUDIX hydrolase
GFB60_RS01090	COG1260	myo-inositol-1-phosphate synthase
GFB60_RS01105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFB60_RS01105	COG1754	DNA topoisomerase type I activity
GFB60_RS01165	COG0406	alpha-ribazole phosphatase activity
GFB60_RS01220	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFB60_RS01225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFB60_RS01275	COG0436	Aminotransferase
GFB60_RS01290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GFB60_RS01290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GFB60_RS01300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFB60_RS01315	COG0742	ribosomal rna small subunit methyltransferase
GFB60_RS01330	COG1837	Belongs to the UPF0109 family
GFB60_RS01365	COG0488	(ABC) transporter
GFB60_RS01375	COG0440	acetolactate synthase activity
GFB60_RS01415	COG0667	Aldo Keto reductase
GFB60_RS01480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFB60_RS01500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFB60_RS01505	COG1530	ribonuclease E activity
GFB60_RS01530	COG0436	Aminotransferase
GFB60_RS01565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GFB60_RS01565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GFB60_RS01570	COG1268	BioY protein
GFB60_RS01575	COG4770	biotin carboxylase activity
GFB60_RS01580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFB60_RS01605	COG0039	L-malate dehydrogenase activity
GFB60_RS01620	COG1704	LemA family
GFB60_RS01630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFB60_RS01635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFB60_RS01655	COG0826	peptidase U32
GFB60_RS01670	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GFB60_RS01680	COG3579	cysteine-type endopeptidase activity
GFB60_RS01685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GFB60_RS01690	COG2755	lipolytic protein G-D-S-L family
GFB60_RS01690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFB60_RS01695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GFB60_RS01700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFB60_RS01710	COG0745	RESPONSE REGULATOR receiver
GFB60_RS01725	COG0581	inorganic phosphate transmembrane transporter activity
GFB60_RS01735	COG2252	PERMEase
GFB60_RS01820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFB60_RS01825	COG0531	amino acid
GFB60_RS01840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFB60_RS01850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFB60_RS01855	COG1739	Uncharacterized protein family UPF0029
GFB60_RS01890	COG1454	alcohol dehydrogenase
GFB60_RS01890	COG1012	belongs to the aldehyde dehydrogenase family
GFB60_RS01950	COG0255	Belongs to the universal ribosomal protein uL29 family
GFB60_RS02085	COG0196	riboflavin kinase activity
GFB60_RS02110	COG0328	RNA-DNA hybrid ribonuclease activity
GFB60_RS02125	COG1803	Methylglyoxal synthase
GFB60_RS02125	COG1597	lipid kinase activity
GFB60_RS02150	COG2197	response regulator
GFB60_RS02170	COG0626	cystathionine gamma-synthase activity
GFB60_RS02180	COG2873	o-acetylhomoserine
GFB60_RS02190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFB60_RS02205	COG3579	cysteine-type endopeptidase activity
GFB60_RS02210	COG0531	amino acid
GFB60_RS02220	COG1113	amino acid transport
GFB60_RS02235	COG4716	Myosin-crossreactive antigen
GFB60_RS02240	COG1063	alcohol dehydrogenase
GFB60_RS02245	COG3321	synthase
GFB60_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
GFB60_RS02245	COG0604	alcohol dehydrogenase
GFB60_RS02260	COG5002	protein histidine kinase activity
GFB60_RS02265	COG0704	Plays a role in the regulation of phosphate uptake
GFB60_RS02270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GFB60_RS02275	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB60_RS02275	COG3942	CHAP domain
GFB60_RS02280	COG0791	NLP P60 protein
GFB60_RS02280	COG1388	LysM domain
GFB60_RS02300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFB60_RS02305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFB60_RS02310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFB60_RS02380	COG3189	MarR family transcriptional regulator
GFB60_RS02390	COG3250	beta-galactosidase activity
GFB60_RS02395	COG1609	Transcriptional regulator
GFB60_RS02430	COG0395	ABC-type sugar transport system, permease component
GFB60_RS02460	COG1216	Glycosyl transferase, family 2
GFB60_RS02465	COG0628	permease
GFB60_RS02500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFB60_RS02515	COG1946	Acyl-CoA thioesterase
GFB60_RS02525	COG0242	peptide deformylase activity
GFB60_RS02530	COG2873	o-acetylhomoserine
GFB60_RS02565	COG3507	Belongs to the glycosyl hydrolase 43 family
GFB60_RS02580	COG1175	transmembrane transport
GFB60_RS02590	COG3507	Belongs to the glycosyl hydrolase 43 family
GFB60_RS02600	COG2272	Belongs to the type-B carboxylesterase lipase family
GFB60_RS02610	COG1070	Carbohydrate kinase
GFB60_RS02615	COG1940	carbohydrate kinase activity
GFB60_RS02635	COG0009	L-threonylcarbamoyladenylate synthase
GFB60_RS02655	COG0561	phosphatase activity
GFB60_RS02660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFB60_RS02680	COG3590	peptidase
GFB60_RS02690	COG0024	Methionine aminopeptidase
GFB60_RS02695	COG0372	Belongs to the citrate synthase family
GFB60_RS02710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GFB60_RS02715	COG2884	Cell division ATP-binding protein ftsE
GFB60_RS02725	COG1388	LysM domain
GFB60_RS02725	COG3942	CHAP domain
GFB60_RS02740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB60_RS02745	COG0765	amino acid transport
GFB60_RS02760	COG0784	Response regulator, receiver
GFB60_RS02760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB60_RS02760	COG2198	Histidine kinase
GFB60_RS02760	COG2205	protein histidine kinase activity
GFB60_RS02765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFB60_RS02785	COG0747	negative chemotaxis
GFB60_RS02790	COG0601	transmembrane transport
GFB60_RS02795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFB60_RS02805	COG4172	Belongs to the ABC transporter superfamily
GFB60_RS02820	COG0514	ATP-dependent DNA helicase (RecQ)
GFB60_RS02900	COG0371	Dehydrogenase
GFB60_RS02915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFB60_RS02920	COG0358	DNA primase activity
GFB60_RS02925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GFB60_RS02935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFB60_RS02940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFB60_RS02945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFB60_RS02950	COG0735	belongs to the Fur family
GFB60_RS02955	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GFB60_RS02960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GFB60_RS02965	COG0151	Belongs to the GarS family
GFB60_RS02980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFB60_RS03035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFB60_RS03115	COG0284	orotidine-5'-phosphate decarboxylase activity
GFB60_RS03140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GFB60_RS03155	COG0560	Phosphoserine phosphatase
GFB60_RS03160	COG0586	Pfam SNARE associated Golgi protein
GFB60_RS03170	COG4122	O-methyltransferase activity
GFB60_RS03200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFB60_RS03240	COG0714	Associated with various cellular activities
GFB60_RS03255	COG1278	Cold shock
GFB60_RS03275	COG0745	RESPONSE REGULATOR receiver
GFB60_RS03280	COG2205	protein histidine kinase activity
GFB60_RS03285	COG1278	Cold shock
GFB60_RS03320	COG1196	nuclear chromosome segregation
GFB60_RS03330	COG1126	abc transporter atp-binding protein
GFB60_RS03335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB60_RS03340	COG0765	amino acid transport
GFB60_RS03345	COG0765	amino acid transport
GFB60_RS03350	COG2326	polyphosphate kinase activity
GFB60_RS03365	COG2814	Major facilitator Superfamily
GFB60_RS03370	COG1022	Amp-dependent synthetase and ligase
GFB60_RS03375	COG3328	transposase activity
GFB60_RS03405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFB60_RS03415	COG0656	L-ascorbic acid biosynthetic process
GFB60_RS03440	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GFB60_RS03460	COG0489	protein tyrosine kinase activity
GFB60_RS03460	COG2151	metal-sulfur cluster biosynthetic enzyme
GFB60_RS03465	COG4721	ABC-type cobalt transport system, permease component
GFB60_RS03490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFB60_RS03525	COG4721	ABC-type cobalt transport system, permease component
GFB60_RS03530	COG4172	Belongs to the ABC transporter superfamily
GFB60_RS03535	COG1136	(ABC) transporter
GFB60_RS03540	COG0577	efflux transmembrane transporter activity
GFB60_RS03550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFB60_RS03640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFB60_RS03645	COG0569	domain protein
GFB60_RS03660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB60_RS03680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFB60_RS03700	COG0799	negative regulation of ribosome biogenesis
GFB60_RS03730	COG0406	alpha-ribazole phosphatase activity
GFB60_RS03735	COG0598	Magnesium transport protein CorA
GFB60_RS03765	COG0802	atpase or kinase
GFB60_RS03820	COG0516	GMP reductase activity
GFB60_RS03830	COG1022	Amp-dependent synthetase and ligase
GFB60_RS03860	COG0575	Belongs to the CDS family
GFB60_RS03900	COG1573	uracil-dna glycosylase
GFB60_RS03915	COG0133	tryptophan synthase activity
GFB60_RS03930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFB60_RS03945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFB60_RS03965	COG1716	ATPase activity
GFB60_RS03980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFB60_RS03985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFB60_RS04035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFB60_RS04055	COG0045	succinate-CoA ligase (ADP-forming) activity
GFB60_RS04090	COG0438	transferase activity, transferring glycosyl groups
GFB60_RS04095	COG1560	Kdo2-lipid A biosynthetic process
GFB60_RS04110	COG0488	(ABC) transporter
GFB60_RS04120	COG0456	acetyltransferase
GFB60_RS04185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFB60_RS04195	COG0436	Aminotransferase
GFB60_RS04205	COG0436	Aminotransferase
GFB60_RS04210	COG0561	phosphatase activity
GFB60_RS04215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFB60_RS04240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFB60_RS04270	COG0488	(ABC) transporter
GFB60_RS04295	COG0450	alkyl hydroperoxide reductase
GFB60_RS04305	COG0583	DNA-binding transcription factor activity
GFB60_RS04345	COG0167	dihydroorotate dehydrogenase activity
GFB60_RS04355	COG0284	orotidine-5'-phosphate decarboxylase activity
GFB60_RS04360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFB60_RS04405	COG1119	ATPase activity
GFB60_RS04410	COG0297	glycogen (starch) synthase activity
GFB60_RS04430	COG0067	glutamate synthase
GFB60_RS04430	COG0070	glutamate synthase
GFB60_RS04430	COG0069	glutamate synthase activity
GFB60_RS04450	COG2860	membrane
GFB60_RS04455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFB60_RS04480	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GFB60_RS04505	COG1702	phosphate starvation-inducible protein PhoH
GFB60_RS04510	COG0537	adenosine 5'-monophosphoramidase activity
GFB60_RS04515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFB60_RS04540	COG2151	metal-sulfur cluster biosynthetic enzyme
GFB60_RS04545	COG0822	iron-sulfur transferase activity
GFB60_RS04555	COG0396	ATPase activity
GFB60_RS04560	COG0719	Fe-S assembly protein
GFB60_RS04570	COG1376	ErfK ybiS ycfS ynhG family protein
GFB60_RS04585	COG1523	belongs to the glycosyl hydrolase 13 family
GFB60_RS04635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GFB60_RS04680	COG0588	phosphoglycerate mutase activity
GFB60_RS04685	COG1950	PFAM Membrane protein of
GFB60_RS04720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GFB60_RS04735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GFB60_RS04750	COG1131	(ABC) transporter
GFB60_RS04755	COG1725	Transcriptional regulator
GFB60_RS04765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFB60_RS04790	COG0563	adenylate kinase activity
GFB60_RS04805	COG3039	Transposase
GFB60_RS04825	COG0280	phosphate acetyltransferase
GFB60_RS04825	COG0857	belongs to the CobB CobQ family
GFB60_RS04830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFB60_RS04860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFB60_RS04875	COG0494	nUDIX hydrolase
GFB60_RS04885	COG0469	pyruvate kinase activity
GFB60_RS04900	COG0237	dephospho-CoA kinase activity
GFB60_RS04905	COG0539	negative regulation of cytoplasmic translation
GFB60_RS04915	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFB60_RS04920	COG1121	(ABC) transporter
GFB60_RS04935	COG1329	Transcriptional regulator
GFB60_RS04945	COG0745	RESPONSE REGULATOR receiver
GFB60_RS04950	COG2205	protein histidine kinase activity
GFB60_RS04980	COG1316	TRANSCRIPTIONal
GFB60_RS04985	COG1316	TRANSCRIPTIONal
GFB60_RS05010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFB60_RS05020	COG1760	l-serine dehydratase
GFB60_RS05065	COG1116	anion transmembrane transporter activity
GFB60_RS05090	COG1472	Belongs to the glycosyl hydrolase 3 family
GFB60_RS05100	COG1966	Carbon starvation protein
GFB60_RS05140	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFB60_RS05140	COG1918	ferrous iron import across plasma membrane
GFB60_RS05160	COG0363	glucosamine-6-phosphate deaminase activity
GFB60_RS05165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFB60_RS05170	COG3340	Belongs to the peptidase S51 family
GFB60_RS05175	COG1114	Component of the transport system for branched-chain amino acids
GFB60_RS05205	COG2233	PERMEase
GFB60_RS05225	COG0012	GTP binding
GFB60_RS05230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFB60_RS05240	COG4585	Histidine kinase
GFB60_RS05245	COG2197	response regulator
GFB60_RS05255	COG1136	(ABC) transporter
GFB60_RS05255	COG0577	efflux transmembrane transporter activity
GFB60_RS05265	COG1122	ATPase activity
GFB60_RS05270	COG2873	o-acetylhomoserine
GFB60_RS05300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GFB60_RS05365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GFB60_RS05370	COG1882	Formate acetyltransferase
GFB60_RS05385	COG1473	amidohydrolase
GFB60_RS05390	COG2011	ABC-type metal ion transport system permease component
GFB60_RS05400	COG1464	Belongs to the NlpA lipoprotein family
GFB60_RS05405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFB60_RS05410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFB60_RS05435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFB60_RS05440	COG4975	Glucose uptake
GFB60_RS05445	COG1201	RNA secondary structure unwinding
GFB60_RS05470	COG0187	DNA topoisomerase II activity
GFB60_RS05475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFB60_RS05485	COG0142	geranyltranstransferase activity
GFB60_RS05505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFB60_RS05515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GFB60_RS05540	COG1396	sequence-specific DNA binding
GFB60_RS05550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFB60_RS05570	COG2357	RelA SpoT domain protein
GFB60_RS05575	COG0670	Belongs to the BI1 family
GFB60_RS05580	COG3804	dihydrodipicolinate reductase
GFB60_RS05595	COG1131	(ABC) transporter
GFB60_RS05600	COG4585	Histidine kinase
GFB60_RS05605	COG2197	response regulator
GFB60_RS05625	COG2182	Extracellular solute-binding protein
GFB60_RS05640	COG0110	maltose O-acetyltransferase activity
GFB60_RS05650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFB60_RS05680	COG0708	Exodeoxyribonuclease III
GFB60_RS05695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFB60_RS05700	COG0601	transmembrane transport
GFB60_RS05705	COG4166	transmembrane transport
GFB60_RS05715	COG1136	(ABC) transporter
GFB60_RS05720	COG0577	efflux transmembrane transporter activity
GFB60_RS05730	COG0287	Prephenate dehydrogenase
GFB60_RS05745	COG1217	gtp-binding protein TYPA
GFB60_RS05750	COG0477	Major facilitator Superfamily
GFB60_RS05780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFB60_RS05795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFB60_RS05805	COG2017	converts alpha-aldose to the beta-anomer
GFB60_RS05830	COG0285	dihydrofolate synthase activity
GFB60_RS05850	COG0006	proline dipeptidase activity
GFB60_RS05855	COG2816	NAD+ diphosphatase activity
GFB60_RS05875	COG0582	viral genome integration into host DNA
GFB60_RS05960	COG0601	transmembrane transport
GFB60_RS06000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFB60_RS06010	COG0768	penicillin binding
GFB60_RS06035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFB60_RS06055	COG1230	cation diffusion facilitator family transporter
GFB60_RS06065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFB60_RS06075	COG1643	Atp-dependent helicase
GFB60_RS06120	COG0587	DNA-directed DNA polymerase activity
GFB60_RS06155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFB60_RS06200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFB60_RS06205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFB60_RS06210	COG1957	nucleoside hydrolase
GFB60_RS06265	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFB60_RS06290	COG0613	PHP domain protein
GFB60_RS06300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFB60_RS06325	COG1126	abc transporter atp-binding protein
GFB60_RS06330	COG0765	amino acid transport
GFB60_RS06335	COG0765	amino acid transport
GFB60_RS06340	COG0436	Aminotransferase
GFB60_RS06345	COG2011	ABC-type metal ion transport system permease component
GFB60_RS06355	COG1464	Belongs to the NlpA lipoprotein family
GFB60_RS06360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFB60_RS06420	COG4166	transmembrane transport
GFB60_RS06425	COG2814	Major facilitator Superfamily
GFB60_RS06430	COG1842	Phage shock protein A
GFB60_RS06450	COG2365	Tyrosine phosphatase family
GFB60_RS06465	COG1132	(ABC) transporter
GFB60_RS06470	COG1132	(ABC) transporter
GFB60_RS06520	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GFB60_RS06525	COG1518	maintenance of DNA repeat elements
GFB60_RS06525	COG1468	defense response to virus
GFB60_RS06560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFB60_RS06560	COG1328	CTP reductase activity
GFB60_RS06565	COG1570	exodeoxyribonuclease VII activity
GFB60_RS06570	COG1722	exodeoxyribonuclease VII activity
GFB60_RS06590	COG0436	Aminotransferase
GFB60_RS06625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFB60_RS06650	COG0210	DNA helicase
GFB60_RS06670	COG0714	Associated with various cellular activities
GFB60_RS06710	COG1194	a g-specific adenine glycosylase
GFB60_RS06715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GFB60_RS06735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFB60_RS06745	COG1349	DNA-binding transcription factor activity
GFB60_RS06750	COG1216	Glycosyl transferase, family 2
GFB60_RS06755	COG0167	dihydroorotate dehydrogenase activity
GFB60_RS06760	COG1902	pentaerythritol trinitrate reductase activity
GFB60_RS06765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFB60_RS06765	COG4499	WXG100 protein secretion system (Wss), protein YukC
GFB60_RS06775	COG0095	Lipoate-protein ligase
GFB60_RS06820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFB60_RS06855	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFB60_RS06865	COG1088	dTDP-glucose 4,6-dehydratase activity
GFB60_RS06885	COG1442	glycosyl transferase family 8
GFB60_RS06885	COG1216	Glycosyl transferase, family 2
GFB60_RS06935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFB60_RS06945	COG2814	Major facilitator Superfamily
GFB60_RS07000	COG4988	ABC transporter
GFB60_RS07015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFB60_RS07025	COG0489	protein tyrosine kinase activity
GFB60_RS07040	COG0083	homoserine kinase activity
GFB60_RS07045	COG0460	homoserine dehydrogenase
GFB60_RS07050	COG0019	diaminopimelate decarboxylase activity
GFB60_RS07065	COG0251	oxidation-reduction process
GFB60_RS07070	COG0395	ABC-type sugar transport system, permease component
GFB60_RS07075	COG3459	Glycosyltransferase 36 associated
GFB60_RS07100	COG0545	Peptidyl-prolyl cis-trans isomerase
GFB60_RS07110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFB60_RS07145	COG0356	it plays a direct role in the translocation of protons across the membrane
GFB60_RS07155	COG0477	Major facilitator Superfamily
GFB60_RS07205	COG0582	viral genome integration into host DNA
GFB60_RS07220	COG0679	Auxin Efflux Carrier
GFB60_RS07225	COG0028	Belongs to the TPP enzyme family
GFB60_RS07250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GFB60_RS07260	COG0745	RESPONSE REGULATOR receiver
GFB60_RS07270	COG0747	negative chemotaxis
GFB60_RS07285	COG1605	Chorismate mutase
GFB60_RS07285	COG0287	Prephenate dehydrogenase
GFB60_RS07350	COG2217	Heavy metal translocating P-type atpase
GFB60_RS07360	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFB60_RS07385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFB60_RS07400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFB60_RS07445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFB60_RS07460	COG1609	Transcriptional regulator
GFB60_RS07495	COG1368	sulfuric ester hydrolase activity
GFB60_RS07500	COG1368	sulfuric ester hydrolase activity
GFB60_RS07505	COG1216	Glycosyl transferase, family 2
GFB60_RS07555	COG1216	Glycosyl transferase, family 2
GFB60_RS07610	COG0084	hydrolase, TatD family'
GFB60_RS07625	COG1132	(ABC) transporter
GFB60_RS07630	COG1132	(ABC) transporter
GFB60_RS07665	COG0586	Pfam SNARE associated Golgi protein
GFB60_RS07685	COG1309	transcriptional regulator
GFB60_RS07690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB60_RS07695	COG0789	Transcriptional regulator
GFB60_RS07700	COG0484	heat shock protein binding
GFB60_RS07730	COG1523	belongs to the glycosyl hydrolase 13 family
GFB60_RS07735	COG3833	ABC-type maltose transport systems, permease component
GFB60_RS07740	COG1175	transmembrane transport
GFB60_RS07750	COG0366	Alpha amylase catalytic
GFB60_RS07775	COG1609	Transcriptional regulator
GFB60_RS07785	COG0366	Alpha amylase catalytic
GFB60_RS07800	COG0778	Nitroreductase
GFB60_RS07810	COG2814	Major facilitator Superfamily
GFB60_RS07870	COG1609	Transcriptional regulator
GFB60_RS07875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFB60_RS07880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFB60_RS07885	COG0366	Alpha amylase catalytic
GFB60_RS07900	COG0395	ABC-type sugar transport system, permease component
GFB60_RS07905	COG1175	transmembrane transport
GFB60_RS07925	COG0037	tRNA processing
GFB60_RS07925	COG0590	tRNA wobble adenosine to inosine editing
GFB60_RS07930	COG0025	NhaP-type Na H and K H
GFB60_RS07950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB60_RS07955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFB60_RS07965	COG3842	ATPase activity
GFB60_RS07970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFB60_RS07990	COG3583	domain protein
GFB60_RS08010	COG0617	tRNA 3'-terminal CCA addition
GFB60_RS08030	COG0492	ferredoxin-NADP+ reductase activity
GFB60_RS08035	COG1475	DNA binding
GFB60_RS08040	COG1192	Involved in chromosome partitioning
GFB60_RS08050	COG1847	R3H domain protein