locus-tag	class	description
CNCMI4602_RS00010	COG0592	DNA-directed DNA polymerase activity
CNCMI4602_RS00025	COG0187	DNA topoisomerase II activity
CNCMI4602_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CNCMI4602_RS00045	COG1272	protein, Hemolysin III
CNCMI4602_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CNCMI4602_RS00055	COG2814	Major facilitator Superfamily
CNCMI4602_RS00070	COG1970	mechanosensitive ion channel activity
CNCMI4602_RS00115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CNCMI4602_RS00120	COG2226	methyltransferase
CNCMI4602_RS00200	COG1401	restriction endodeoxyribonuclease activity
CNCMI4602_RS00250	COG1418	mRNA catabolic process
CNCMI4602_RS00270	COG3231	kanamycin kinase activity
CNCMI4602_RS00275	COG0783	Belongs to the Dps family
CNCMI4602_RS00280	COG1253	flavin adenine dinucleotide binding
CNCMI4602_RS00285	COG0288	reversible hydration of carbon dioxide
CNCMI4602_RS00290	COG1609	Transcriptional regulator
CNCMI4602_RS00305	COG4214	carbohydrate transport
CNCMI4602_RS00325	COG1129	ABC transporter
CNCMI4602_RS00335	COG1609	Transcriptional regulator
CNCMI4602_RS00340	COG3534	alpha-L-arabinofuranosidase
CNCMI4602_RS00360	COG0656	L-ascorbic acid biosynthetic process
CNCMI4602_RS00365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CNCMI4602_RS00375	COG0180	Tryptophanyl-tRNA synthetase
CNCMI4602_RS00395	COG0058	SHG alpha-glucan phosphorylase activity
CNCMI4602_RS00435	COG3764	Sortase (surface protein transpeptidase)
CNCMI4602_RS00450	COG0515	serine threonine protein kinase
CNCMI4602_RS00455	COG0768	penicillin binding
CNCMI4602_RS00490	COG0697	spore germination
CNCMI4602_RS00505	COG2226	methyltransferase
CNCMI4602_RS00515	COG2261	transglycosylase associated protein
CNCMI4602_RS00520	COG2261	transglycosylase associated protein
CNCMI4602_RS00545	COG2217	Heavy metal translocating P-type atpase
CNCMI4602_RS00560	COG0343	queuine tRNA-ribosyltransferase activity
CNCMI4602_RS00585	COG2814	Major facilitator Superfamily
CNCMI4602_RS00600	COG3041	Addiction module toxin RelE StbE family
CNCMI4602_RS00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CNCMI4602_RS00635	COG0667	Aldo Keto reductase
CNCMI4602_RS00675	COG1063	alcohol dehydrogenase
CNCMI4602_RS00680	COG0583	DNA-binding transcription factor activity
CNCMI4602_RS00690	COG0191	fructose-bisphosphate aldolase activity
CNCMI4602_RS00755	COG2190	(PTS) system
CNCMI4602_RS00755	COG2211	Major facilitator Superfamily
CNCMI4602_RS00780	COG4770	biotin carboxylase activity
CNCMI4602_RS00795	COG0477	Major facilitator Superfamily
CNCMI4602_RS00865	COG0390	transport system, permease component
CNCMI4602_RS00875	COG1113	amino acid transport
CNCMI4602_RS00880	COG1136	(ABC) transporter
CNCMI4602_RS00880	COG0577	efflux transmembrane transporter activity
CNCMI4602_RS00890	COG1113	amino acid transport
CNCMI4602_RS00905	COG4591	ABC-type transport system involved in lipoprotein release permease component
CNCMI4602_RS00905	COG1136	(ABC) transporter
CNCMI4602_RS00910	COG1846	Transcriptional regulator
CNCMI4602_RS00930	COG0671	phosphoesterase, PA-phosphatase related
CNCMI4602_RS00935	COG0110	maltose O-acetyltransferase activity
CNCMI4602_RS00980	COG1129	ABC transporter
CNCMI4602_RS01065	COG1309	transcriptional regulator
CNCMI4602_RS01085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CNCMI4602_RS01090	COG0305	Participates in initiation and elongation during chromosome replication
CNCMI4602_RS01095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CNCMI4602_RS01115	COG0584	glycerophosphoryl diester phosphodiesterase
CNCMI4602_RS01135	COG0406	alpha-ribazole phosphatase activity
CNCMI4602_RS01135	COG0494	nUDIX hydrolase
CNCMI4602_RS01140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CNCMI4602_RS01220	COG1260	myo-inositol-1-phosphate synthase
CNCMI4602_RS01235	COG1754	DNA topoisomerase type I activity
CNCMI4602_RS01235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CNCMI4602_RS01315	COG0406	alpha-ribazole phosphatase activity
CNCMI4602_RS01370	COG0446	pyridine nucleotide-disulphide oxidoreductase
CNCMI4602_RS01380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CNCMI4602_RS01415	COG0668	transmembrane transport
CNCMI4602_RS01435	COG0436	Aminotransferase
CNCMI4602_RS01450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CNCMI4602_RS01450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CNCMI4602_RS01460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CNCMI4602_RS01465	COG0742	ribosomal rna small subunit methyltransferase
CNCMI4602_RS01480	COG1837	Belongs to the UPF0109 family
CNCMI4602_RS01525	COG0488	(ABC) transporter
CNCMI4602_RS01535	COG0440	acetolactate synthase activity
CNCMI4602_RS01575	COG0667	Aldo Keto reductase
CNCMI4602_RS01650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CNCMI4602_RS01670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CNCMI4602_RS01675	COG1530	ribonuclease E activity
CNCMI4602_RS01710	COG0436	Aminotransferase
CNCMI4602_RS01750	COG1268	BioY protein
CNCMI4602_RS01755	COG4770	biotin carboxylase activity
CNCMI4602_RS01760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CNCMI4602_RS01765	COG0159	tryptophan synthase activity
CNCMI4602_RS01785	COG0039	L-malate dehydrogenase activity
CNCMI4602_RS01800	COG1704	LemA family
CNCMI4602_RS01810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CNCMI4602_RS01815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CNCMI4602_RS01830	COG0656	L-ascorbic acid biosynthetic process
CNCMI4602_RS01835	COG0826	peptidase U32
CNCMI4602_RS01855	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CNCMI4602_RS01865	COG3579	cysteine-type endopeptidase activity
CNCMI4602_RS01870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CNCMI4602_RS01875	COG2755	lipolytic protein G-D-S-L family
CNCMI4602_RS01875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CNCMI4602_RS01880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CNCMI4602_RS01885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CNCMI4602_RS01890	COG5002	protein histidine kinase activity
CNCMI4602_RS01895	COG0745	RESPONSE REGULATOR receiver
CNCMI4602_RS01910	COG0581	inorganic phosphate transmembrane transporter activity
CNCMI4602_RS01940	COG2252	PERMEase
CNCMI4602_RS01955	COG0587	DNA-directed DNA polymerase activity
CNCMI4602_RS01965	COG1401	restriction endodeoxyribonuclease activity
CNCMI4602_RS02015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CNCMI4602_RS02055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CNCMI4602_RS02060	COG0531	amino acid
CNCMI4602_RS02075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CNCMI4602_RS02085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CNCMI4602_RS02090	COG1739	Uncharacterized protein family UPF0029
CNCMI4602_RS02125	COG1454	alcohol dehydrogenase
CNCMI4602_RS02125	COG1012	belongs to the aldehyde dehydrogenase family
CNCMI4602_RS02180	COG0255	Belongs to the universal ribosomal protein uL29 family
CNCMI4602_RS02320	COG0196	riboflavin kinase activity
CNCMI4602_RS02345	COG0328	RNA-DNA hybrid ribonuclease activity
CNCMI4602_RS02395	COG2197	response regulator
CNCMI4602_RS02430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CNCMI4602_RS02460	COG3579	cysteine-type endopeptidase activity
CNCMI4602_RS02465	COG0531	amino acid
CNCMI4602_RS02475	COG1113	amino acid transport
CNCMI4602_RS02490	COG4716	Myosin-crossreactive antigen
CNCMI4602_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
CNCMI4602_RS02495	COG0604	alcohol dehydrogenase
CNCMI4602_RS02495	COG3321	synthase
CNCMI4602_RS02505	COG5002	protein histidine kinase activity
CNCMI4602_RS02510	COG0704	Plays a role in the regulation of phosphate uptake
CNCMI4602_RS02515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CNCMI4602_RS02520	COG1705	Flagellar rod assembly protein muramidase FlgJ
CNCMI4602_RS02520	COG3942	CHAP domain
CNCMI4602_RS02525	COG0791	NLP P60 protein
CNCMI4602_RS02525	COG1388	LysM domain
CNCMI4602_RS02545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CNCMI4602_RS02550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CNCMI4602_RS02555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CNCMI4602_RS02630	COG3189	MarR family transcriptional regulator
CNCMI4602_RS02640	COG3250	beta-galactosidase activity
CNCMI4602_RS02645	COG1609	Transcriptional regulator
CNCMI4602_RS02690	COG1216	Glycosyl transferase, family 2
CNCMI4602_RS02695	COG0628	permease
CNCMI4602_RS02730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CNCMI4602_RS02745	COG1946	Acyl-CoA thioesterase
CNCMI4602_RS02755	COG0242	peptide deformylase activity
CNCMI4602_RS02760	COG2873	o-acetylhomoserine
CNCMI4602_RS02795	COG3507	Belongs to the glycosyl hydrolase 43 family
CNCMI4602_RS02800	COG1609	Transcriptional regulator
CNCMI4602_RS02810	COG1175	transmembrane transport
CNCMI4602_RS02820	COG3507	Belongs to the glycosyl hydrolase 43 family
CNCMI4602_RS02830	COG2272	Belongs to the type-B carboxylesterase lipase family
CNCMI4602_RS02840	COG1070	Carbohydrate kinase
CNCMI4602_RS02865	COG0009	L-threonylcarbamoyladenylate synthase
CNCMI4602_RS02885	COG0561	phosphatase activity
CNCMI4602_RS02890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CNCMI4602_RS02910	COG3590	peptidase
CNCMI4602_RS02920	COG0024	Methionine aminopeptidase
CNCMI4602_RS02925	COG0372	Belongs to the citrate synthase family
CNCMI4602_RS02945	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CNCMI4602_RS02950	COG2884	Cell division ATP-binding protein ftsE
CNCMI4602_RS02960	COG1388	LysM domain
CNCMI4602_RS02960	COG3942	CHAP domain
CNCMI4602_RS02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CNCMI4602_RS02985	COG0765	amino acid transport
CNCMI4602_RS03030	COG0601	transmembrane transport
CNCMI4602_RS03035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CNCMI4602_RS03060	COG0514	ATP-dependent DNA helicase (RecQ)
CNCMI4602_RS03135	COG0371	Dehydrogenase
CNCMI4602_RS03150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CNCMI4602_RS03155	COG0358	DNA primase activity
CNCMI4602_RS03160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CNCMI4602_RS03170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CNCMI4602_RS03175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CNCMI4602_RS03180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CNCMI4602_RS03185	COG0735	belongs to the Fur family
CNCMI4602_RS03190	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CNCMI4602_RS03195	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CNCMI4602_RS03200	COG0151	Belongs to the GarS family
CNCMI4602_RS03215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CNCMI4602_RS03235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CNCMI4602_RS03315	COG0284	orotidine-5'-phosphate decarboxylase activity
CNCMI4602_RS03340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CNCMI4602_RS03355	COG0560	Phosphoserine phosphatase
CNCMI4602_RS03360	COG0586	Pfam SNARE associated Golgi protein
CNCMI4602_RS03370	COG4122	O-methyltransferase activity
CNCMI4602_RS03400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CNCMI4602_RS03440	COG0714	Associated with various cellular activities
CNCMI4602_RS03455	COG1278	Cold shock
CNCMI4602_RS03475	COG0745	RESPONSE REGULATOR receiver
CNCMI4602_RS03480	COG2205	protein histidine kinase activity
CNCMI4602_RS03485	COG1278	Cold shock
CNCMI4602_RS03520	COG1196	nuclear chromosome segregation
CNCMI4602_RS03530	COG1126	abc transporter atp-binding protein
CNCMI4602_RS03535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CNCMI4602_RS03540	COG0765	amino acid transport
CNCMI4602_RS03545	COG0765	amino acid transport
CNCMI4602_RS03550	COG2326	polyphosphate kinase activity
CNCMI4602_RS03565	COG2814	Major facilitator Superfamily
CNCMI4602_RS03570	COG1022	Amp-dependent synthetase and ligase
CNCMI4602_RS03595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CNCMI4602_RS03605	COG0656	L-ascorbic acid biosynthetic process
CNCMI4602_RS03625	COG0436	Aminotransferase
CNCMI4602_RS03630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CNCMI4602_RS03650	COG2151	metal-sulfur cluster biosynthetic enzyme
CNCMI4602_RS03650	COG0489	protein tyrosine kinase activity
CNCMI4602_RS03675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CNCMI4602_RS03720	COG1136	(ABC) transporter
CNCMI4602_RS03735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CNCMI4602_RS03825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CNCMI4602_RS03830	COG0569	domain protein
CNCMI4602_RS03840	COG0497	DNA recombination
CNCMI4602_RS03845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CNCMI4602_RS03865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CNCMI4602_RS03885	COG0799	negative regulation of ribosome biogenesis
CNCMI4602_RS03915	COG0406	alpha-ribazole phosphatase activity
CNCMI4602_RS03920	COG0598	Magnesium transport protein CorA
CNCMI4602_RS03925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CNCMI4602_RS03950	COG0802	atpase or kinase
CNCMI4602_RS04010	COG0516	GMP reductase activity
CNCMI4602_RS04020	COG1022	Amp-dependent synthetase and ligase
CNCMI4602_RS04050	COG0575	Belongs to the CDS family
CNCMI4602_RS04065	COG1131	(ABC) transporter
CNCMI4602_RS04090	COG1573	uracil-dna glycosylase
CNCMI4602_RS04110	COG0133	tryptophan synthase activity
CNCMI4602_RS04125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CNCMI4602_RS04140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CNCMI4602_RS04160	COG1716	ATPase activity
CNCMI4602_RS04175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CNCMI4602_RS04180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CNCMI4602_RS04230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CNCMI4602_RS04255	COG0045	succinate-CoA ligase (ADP-forming) activity
CNCMI4602_RS04290	COG0438	transferase activity, transferring glycosyl groups
CNCMI4602_RS04295	COG1560	Kdo2-lipid A biosynthetic process
CNCMI4602_RS04310	COG0488	(ABC) transporter
CNCMI4602_RS04320	COG0456	acetyltransferase
CNCMI4602_RS04335	COG0488	(ABC) transporter
CNCMI4602_RS04410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CNCMI4602_RS04420	COG0436	Aminotransferase
CNCMI4602_RS04430	COG0436	Aminotransferase
CNCMI4602_RS04435	COG0561	phosphatase activity
CNCMI4602_RS04440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CNCMI4602_RS04465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CNCMI4602_RS04495	COG0488	(ABC) transporter
CNCMI4602_RS04520	COG0450	alkyl hydroperoxide reductase
CNCMI4602_RS04530	COG0583	DNA-binding transcription factor activity
CNCMI4602_RS04605	COG0167	dihydroorotate dehydrogenase activity
CNCMI4602_RS04610	COG0543	2 iron, 2 sulfur cluster binding
CNCMI4602_RS04615	COG0284	orotidine-5'-phosphate decarboxylase activity
CNCMI4602_RS04620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CNCMI4602_RS04645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CNCMI4602_RS04665	COG1119	ATPase activity
CNCMI4602_RS04670	COG0297	glycogen (starch) synthase activity
CNCMI4602_RS04690	COG0070	glutamate synthase
CNCMI4602_RS04690	COG0069	glutamate synthase activity
CNCMI4602_RS04690	COG0067	glutamate synthase
CNCMI4602_RS04710	COG2860	membrane
CNCMI4602_RS04715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CNCMI4602_RS04740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CNCMI4602_RS04765	COG1702	phosphate starvation-inducible protein PhoH
CNCMI4602_RS04770	COG0537	adenosine 5'-monophosphoramidase activity
CNCMI4602_RS04775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CNCMI4602_RS04795	COG2151	metal-sulfur cluster biosynthetic enzyme
CNCMI4602_RS04800	COG0822	iron-sulfur transferase activity
CNCMI4602_RS04810	COG0396	ATPase activity
CNCMI4602_RS04815	COG0719	Fe-S assembly protein
CNCMI4602_RS04825	COG1376	ErfK ybiS ycfS ynhG family protein
CNCMI4602_RS04860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CNCMI4602_RS04905	COG0588	phosphoglycerate mutase activity
CNCMI4602_RS04910	COG1950	PFAM Membrane protein of
CNCMI4602_RS04940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CNCMI4602_RS04955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CNCMI4602_RS04960	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CNCMI4602_RS04970	COG1131	(ABC) transporter
CNCMI4602_RS04975	COG1725	Transcriptional regulator
CNCMI4602_RS04985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CNCMI4602_RS05035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CNCMI4602_RS05065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CNCMI4602_RS05080	COG0494	nUDIX hydrolase
CNCMI4602_RS05090	COG0469	pyruvate kinase activity
CNCMI4602_RS05120	COG0803	Belongs to the bacterial solute-binding protein 9 family
CNCMI4602_RS05125	COG1121	(ABC) transporter
CNCMI4602_RS05140	COG1329	Transcriptional regulator
CNCMI4602_RS05150	COG0745	RESPONSE REGULATOR receiver
CNCMI4602_RS05155	COG2205	protein histidine kinase activity
CNCMI4602_RS05185	COG1316	TRANSCRIPTIONal
CNCMI4602_RS05190	COG1316	TRANSCRIPTIONal
CNCMI4602_RS05215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CNCMI4602_RS05225	COG1760	l-serine dehydratase
CNCMI4602_RS05270	COG1116	anion transmembrane transporter activity
CNCMI4602_RS05305	COG1966	Carbon starvation protein
CNCMI4602_RS05315	COG1116	anion transmembrane transporter activity
CNCMI4602_RS05340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CNCMI4602_RS05340	COG1918	ferrous iron import across plasma membrane
CNCMI4602_RS05365	COG0363	glucosamine-6-phosphate deaminase activity
CNCMI4602_RS05370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CNCMI4602_RS05375	COG3340	Belongs to the peptidase S51 family
CNCMI4602_RS05380	COG1114	Component of the transport system for branched-chain amino acids
CNCMI4602_RS05390	COG2217	Heavy metal translocating P-type atpase
CNCMI4602_RS05400	COG0513	Belongs to the DEAD box helicase family
CNCMI4602_RS05410	COG2233	PERMEase
CNCMI4602_RS05430	COG0012	GTP binding
CNCMI4602_RS05435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CNCMI4602_RS05445	COG4585	Histidine kinase
CNCMI4602_RS05450	COG2197	response regulator
CNCMI4602_RS05460	COG1136	(ABC) transporter
CNCMI4602_RS05460	COG0577	efflux transmembrane transporter activity
CNCMI4602_RS05470	COG1122	ATPase activity
CNCMI4602_RS05475	COG2873	o-acetylhomoserine
CNCMI4602_RS05500	COG1053	succinate dehydrogenase
CNCMI4602_RS05505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CNCMI4602_RS05570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CNCMI4602_RS05575	COG1882	Formate acetyltransferase
CNCMI4602_RS05590	COG1473	amidohydrolase
CNCMI4602_RS05595	COG2011	ABC-type metal ion transport system permease component
CNCMI4602_RS05605	COG1464	Belongs to the NlpA lipoprotein family
CNCMI4602_RS05615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CNCMI4602_RS05640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CNCMI4602_RS05650	COG1201	RNA secondary structure unwinding
CNCMI4602_RS05675	COG0438	transferase activity, transferring glycosyl groups
CNCMI4602_RS05685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CNCMI4602_RS05695	COG0142	geranyltranstransferase activity
CNCMI4602_RS05715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CNCMI4602_RS05725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CNCMI4602_RS05755	COG1396	sequence-specific DNA binding
CNCMI4602_RS05765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CNCMI4602_RS05785	COG2357	RelA SpoT domain protein
CNCMI4602_RS05790	COG0670	Belongs to the BI1 family
CNCMI4602_RS05795	COG3804	dihydrodipicolinate reductase
CNCMI4602_RS05810	COG1131	(ABC) transporter
CNCMI4602_RS05815	COG4585	Histidine kinase
CNCMI4602_RS05820	COG2197	response regulator
CNCMI4602_RS05830	COG0110	maltose O-acetyltransferase activity
CNCMI4602_RS05840	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CNCMI4602_RS05870	COG0708	Exodeoxyribonuclease III
CNCMI4602_RS05885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CNCMI4602_RS05890	COG0601	transmembrane transport
CNCMI4602_RS05900	COG4166	transmembrane transport
CNCMI4602_RS05910	COG1136	(ABC) transporter
CNCMI4602_RS05910	COG0577	efflux transmembrane transporter activity
CNCMI4602_RS05915	COG0577	efflux transmembrane transporter activity
CNCMI4602_RS05925	COG0287	Prephenate dehydrogenase
CNCMI4602_RS05940	COG1217	gtp-binding protein TYPA
CNCMI4602_RS05945	COG0477	Major facilitator Superfamily
CNCMI4602_RS05975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CNCMI4602_RS05990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CNCMI4602_RS06000	COG2017	converts alpha-aldose to the beta-anomer
CNCMI4602_RS06025	COG0285	dihydrofolate synthase activity
CNCMI4602_RS06050	COG0006	proline dipeptidase activity
CNCMI4602_RS06055	COG2816	NAD+ diphosphatase activity
CNCMI4602_RS06095	COG0601	transmembrane transport
CNCMI4602_RS06145	COG0768	penicillin binding
CNCMI4602_RS06170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CNCMI4602_RS06190	COG1230	cation diffusion facilitator family transporter
CNCMI4602_RS06200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CNCMI4602_RS06210	COG1643	Atp-dependent helicase
CNCMI4602_RS06255	COG0587	DNA-directed DNA polymerase activity
CNCMI4602_RS06290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CNCMI4602_RS06340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CNCMI4602_RS06350	COG1957	nucleoside hydrolase
CNCMI4602_RS06410	COG3480	Lon protease (S16) C-terminal proteolytic domain
CNCMI4602_RS06435	COG0613	PHP domain protein
CNCMI4602_RS06445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CNCMI4602_RS06470	COG1126	abc transporter atp-binding protein
CNCMI4602_RS06475	COG0765	amino acid transport
CNCMI4602_RS06480	COG0765	amino acid transport
CNCMI4602_RS06485	COG0436	Aminotransferase
CNCMI4602_RS06495	COG2011	ABC-type metal ion transport system permease component
CNCMI4602_RS06505	COG1464	Belongs to the NlpA lipoprotein family
CNCMI4602_RS06510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CNCMI4602_RS06520	COG2176	DNA-directed DNA polymerase activity
CNCMI4602_RS06575	COG4166	transmembrane transport
CNCMI4602_RS06615	COG2814	Major facilitator Superfamily
CNCMI4602_RS06620	COG1842	Phage shock protein A
CNCMI4602_RS06660	COG1132	(ABC) transporter
CNCMI4602_RS06665	COG1132	(ABC) transporter
CNCMI4602_RS06680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CNCMI4602_RS06715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CNCMI4602_RS06715	COG1328	CTP reductase activity
CNCMI4602_RS06720	COG1570	exodeoxyribonuclease VII activity
CNCMI4602_RS06725	COG1722	exodeoxyribonuclease VII activity
CNCMI4602_RS06745	COG0436	Aminotransferase
CNCMI4602_RS06780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CNCMI4602_RS06805	COG0210	DNA helicase
CNCMI4602_RS06810	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CNCMI4602_RS06825	COG0714	Associated with various cellular activities
CNCMI4602_RS06865	COG1194	a g-specific adenine glycosylase
CNCMI4602_RS06870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CNCMI4602_RS06890	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CNCMI4602_RS06900	COG1349	DNA-binding transcription factor activity
CNCMI4602_RS06905	COG1216	Glycosyl transferase, family 2
CNCMI4602_RS06910	COG0167	dihydroorotate dehydrogenase activity
CNCMI4602_RS06915	COG1902	pentaerythritol trinitrate reductase activity
CNCMI4602_RS06920	COG4499	WXG100 protein secretion system (Wss), protein YukC
CNCMI4602_RS06920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CNCMI4602_RS06930	COG0095	Lipoate-protein ligase
CNCMI4602_RS06975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CNCMI4602_RS07005	COG1088	dTDP-glucose 4,6-dehydratase activity
CNCMI4602_RS07020	COG1442	glycosyl transferase family 8
CNCMI4602_RS07020	COG1216	Glycosyl transferase, family 2
CNCMI4602_RS07055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CNCMI4602_RS07065	COG2814	Major facilitator Superfamily
CNCMI4602_RS07090	COG4988	ABC transporter
CNCMI4602_RS07105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CNCMI4602_RS07130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CNCMI4602_RS07135	COG1518	maintenance of DNA repeat elements
CNCMI4602_RS07150	COG1857	crispr-associated protein
CNCMI4602_RS07170	COG0083	homoserine kinase activity
CNCMI4602_RS07175	COG0460	homoserine dehydrogenase
CNCMI4602_RS07180	COG0019	diaminopimelate decarboxylase activity
CNCMI4602_RS07195	COG0251	oxidation-reduction process
CNCMI4602_RS07200	COG0395	ABC-type sugar transport system, permease component
CNCMI4602_RS07230	COG0545	Peptidyl-prolyl cis-trans isomerase
CNCMI4602_RS07240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CNCMI4602_RS07275	COG0356	it plays a direct role in the translocation of protons across the membrane
CNCMI4602_RS07310	COG0679	Auxin Efflux Carrier
CNCMI4602_RS07315	COG0028	Belongs to the TPP enzyme family
CNCMI4602_RS07340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CNCMI4602_RS07350	COG0745	RESPONSE REGULATOR receiver
CNCMI4602_RS07365	COG0747	negative chemotaxis
CNCMI4602_RS07380	COG0287	Prephenate dehydrogenase
CNCMI4602_RS07380	COG1605	Chorismate mutase
CNCMI4602_RS07445	COG2217	Heavy metal translocating P-type atpase
CNCMI4602_RS07455	COG0179	Fumarylacetoacetate (FAA) hydrolase
CNCMI4602_RS07480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CNCMI4602_RS07490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CNCMI4602_RS07550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CNCMI4602_RS07565	COG1609	Transcriptional regulator
CNCMI4602_RS07605	COG1215	transferase activity, transferring glycosyl groups
CNCMI4602_RS07610	COG1368	sulfuric ester hydrolase activity
CNCMI4602_RS07615	COG1216	Glycosyl transferase, family 2
CNCMI4602_RS07685	COG0084	hydrolase, TatD family'
CNCMI4602_RS07745	COG0586	Pfam SNARE associated Golgi protein
CNCMI4602_RS07760	COG1472	Belongs to the glycosyl hydrolase 3 family
CNCMI4602_RS07765	COG1309	transcriptional regulator
CNCMI4602_RS07775	COG3041	Addiction module toxin RelE StbE family
CNCMI4602_RS07785	COG0789	Transcriptional regulator
CNCMI4602_RS07790	COG0484	heat shock protein binding
CNCMI4602_RS07805	COG1609	Transcriptional regulator
CNCMI4602_RS07815	COG0546	phosphoglycolate phosphatase activity
CNCMI4602_RS07820	COG1523	belongs to the glycosyl hydrolase 13 family
CNCMI4602_RS07825	COG3833	ABC-type maltose transport systems, permease component
CNCMI4602_RS07830	COG1175	transmembrane transport
CNCMI4602_RS07865	COG1609	Transcriptional regulator
CNCMI4602_RS07870	COG2182	Extracellular solute-binding protein
CNCMI4602_RS07875	COG0366	Alpha amylase catalytic
CNCMI4602_RS07890	COG0778	Nitroreductase
CNCMI4602_RS07900	COG0477	Major facilitator Superfamily
CNCMI4602_RS07965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CNCMI4602_RS07970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CNCMI4602_RS07990	COG0366	Alpha amylase catalytic
CNCMI4602_RS08015	COG0395	ABC-type sugar transport system, permease component
CNCMI4602_RS08020	COG1175	transmembrane transport
CNCMI4602_RS08040	COG0590	tRNA wobble adenosine to inosine editing
CNCMI4602_RS08040	COG0037	tRNA processing
CNCMI4602_RS08045	COG0025	NhaP-type Na H and K H
CNCMI4602_RS08065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CNCMI4602_RS08075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CNCMI4602_RS08080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CNCMI4602_RS08090	COG3842	ATPase activity
CNCMI4602_RS08095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CNCMI4602_RS08115	COG3583	domain protein
CNCMI4602_RS08135	COG0617	tRNA 3'-terminal CCA addition
CNCMI4602_RS08155	COG0492	ferredoxin-NADP+ reductase activity
CNCMI4602_RS08160	COG1475	DNA binding
CNCMI4602_RS08165	COG1192	Involved in chromosome partitioning
CNCMI4602_RS08175	COG1847	R3H domain protein