locus-tag	class	description
A4U98_RS00010	COG0714	Associated with various cellular activities
A4U98_RS00050	COG1194	a g-specific adenine glycosylase
A4U98_RS00055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4U98_RS00075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4U98_RS00085	COG1349	DNA-binding transcription factor activity
A4U98_RS00090	COG1216	Glycosyl transferase, family 2
A4U98_RS00095	COG0167	dihydroorotate dehydrogenase activity
A4U98_RS00100	COG1902	pentaerythritol trinitrate reductase activity
A4U98_RS00105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4U98_RS00105	COG4499	WXG100 protein secretion system (Wss), protein YukC
A4U98_RS00115	COG0095	Lipoate-protein ligase
A4U98_RS00160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4U98_RS00185	COG1088	dTDP-glucose 4,6-dehydratase activity
A4U98_RS00210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4U98_RS00220	COG2814	Major facilitator Superfamily
A4U98_RS00235	COG1609	Transcriptional regulator
A4U98_RS00245	COG0395	ABC-type sugar transport system, permease component
A4U98_RS00270	COG1368	sulfuric ester hydrolase activity
A4U98_RS00280	COG0438	transferase activity, transferring glycosyl groups
A4U98_RS00285	COG2244	polysaccharide biosynthetic process
A4U98_RS00300	COG1216	Glycosyl transferase, family 2
A4U98_RS00355	COG0438	transferase activity, transferring glycosyl groups
A4U98_RS00360	COG4750	Nucleotidyl transferase
A4U98_RS00375	COG3328	transposase activity
A4U98_RS00405	COG2826	transposase and inactivated derivatives, IS30 family
A4U98_RS00420	COG3475	LICD family
A4U98_RS00440	COG4988	ABC transporter
A4U98_RS00455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4U98_RS00465	COG0489	protein tyrosine kinase activity
A4U98_RS00505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4U98_RS00510	COG1518	maintenance of DNA repeat elements
A4U98_RS00525	COG1857	crispr-associated protein
A4U98_RS00545	COG0083	homoserine kinase activity
A4U98_RS00550	COG0460	homoserine dehydrogenase
A4U98_RS00555	COG0019	diaminopimelate decarboxylase activity
A4U98_RS00570	COG0251	oxidation-reduction process
A4U98_RS00575	COG0395	ABC-type sugar transport system, permease component
A4U98_RS00605	COG0545	Peptidyl-prolyl cis-trans isomerase
A4U98_RS00615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4U98_RS00650	COG0356	it plays a direct role in the translocation of protons across the membrane
A4U98_RS00685	COG0679	Auxin Efflux Carrier
A4U98_RS00690	COG0028	Belongs to the TPP enzyme family
A4U98_RS00715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4U98_RS00725	COG0745	RESPONSE REGULATOR receiver
A4U98_RS00735	COG0747	negative chemotaxis
A4U98_RS00750	COG0287	Prephenate dehydrogenase
A4U98_RS00750	COG1605	Chorismate mutase
A4U98_RS00815	COG2217	Heavy metal translocating P-type atpase
A4U98_RS00825	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4U98_RS00830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4U98_RS00845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4U98_RS00855	COG2184	nucleotidyltransferase activity
A4U98_RS00870	COG3550	peptidyl-serine autophosphorylation
A4U98_RS00895	COG3843	relaxase mobilization nuclease domain protein
A4U98_RS00945	COG1388	LysM domain
A4U98_RS00945	COG3942	CHAP domain
A4U98_RS01120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U98_RS01135	COG1609	Transcriptional regulator
A4U98_RS01165	COG1215	transferase activity, transferring glycosyl groups
A4U98_RS01170	COG1368	sulfuric ester hydrolase activity
A4U98_RS01175	COG1368	sulfuric ester hydrolase activity
A4U98_RS01180	COG1216	Glycosyl transferase, family 2
A4U98_RS01250	COG0084	hydrolase, TatD family'
A4U98_RS01305	COG0586	Pfam SNARE associated Golgi protein
A4U98_RS01325	COG1309	transcriptional regulator
A4U98_RS01335	COG3041	Addiction module toxin RelE StbE family
A4U98_RS01345	COG0789	Transcriptional regulator
A4U98_RS01350	COG0484	heat shock protein binding
A4U98_RS01370	COG1609	Transcriptional regulator
A4U98_RS01380	COG0546	phosphoglycolate phosphatase activity
A4U98_RS01385	COG1523	belongs to the glycosyl hydrolase 13 family
A4U98_RS01390	COG3833	ABC-type maltose transport systems, permease component
A4U98_RS01395	COG1175	transmembrane transport
A4U98_RS01430	COG1609	Transcriptional regulator
A4U98_RS01435	COG2182	Extracellular solute-binding protein
A4U98_RS01440	COG0366	Alpha amylase catalytic
A4U98_RS01455	COG0778	Nitroreductase
A4U98_RS01465	COG0477	Major facilitator Superfamily
A4U98_RS01530	COG1609	Transcriptional regulator
A4U98_RS01535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4U98_RS01540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4U98_RS01550	COG0366	Alpha amylase catalytic
A4U98_RS01565	COG0395	ABC-type sugar transport system, permease component
A4U98_RS01570	COG1175	transmembrane transport
A4U98_RS01590	COG0037	tRNA processing
A4U98_RS01590	COG0590	tRNA wobble adenosine to inosine editing
A4U98_RS01595	COG0025	NhaP-type Na H and K H
A4U98_RS01615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4U98_RS01620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U98_RS01625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U98_RS01635	COG3842	ATPase activity
A4U98_RS01640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4U98_RS01660	COG3583	domain protein
A4U98_RS01680	COG0617	tRNA 3'-terminal CCA addition
A4U98_RS01700	COG0492	ferredoxin-NADP+ reductase activity
A4U98_RS01705	COG1475	DNA binding
A4U98_RS01710	COG1192	Involved in chromosome partitioning
A4U98_RS01720	COG1847	R3H domain protein
A4U98_RS01745	COG0592	DNA-directed DNA polymerase activity
A4U98_RS01760	COG0187	DNA topoisomerase II activity
A4U98_RS01765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4U98_RS01780	COG1272	protein, Hemolysin III
A4U98_RS01785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4U98_RS01790	COG2814	Major facilitator Superfamily
A4U98_RS01805	COG1970	mechanosensitive ion channel activity
A4U98_RS01845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4U98_RS01850	COG2226	methyltransferase
A4U98_RS01950	COG3231	kanamycin kinase activity
A4U98_RS01955	COG0783	Belongs to the Dps family
A4U98_RS01960	COG1253	flavin adenine dinucleotide binding
A4U98_RS01965	COG0288	reversible hydration of carbon dioxide
A4U98_RS01970	COG1609	Transcriptional regulator
A4U98_RS01985	COG4214	carbohydrate transport
A4U98_RS02000	COG1846	Transcriptional regulator
A4U98_RS02000	COG1940	carbohydrate kinase activity
A4U98_RS02015	COG1609	Transcriptional regulator
A4U98_RS02020	COG3534	alpha-L-arabinofuranosidase
A4U98_RS02040	COG0656	L-ascorbic acid biosynthetic process
A4U98_RS02045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A4U98_RS02055	COG0180	Tryptophanyl-tRNA synthetase
A4U98_RS02075	COG0058	SHG alpha-glucan phosphorylase activity
A4U98_RS02105	COG3764	Sortase (surface protein transpeptidase)
A4U98_RS02120	COG0515	serine threonine protein kinase
A4U98_RS02125	COG0768	penicillin binding
A4U98_RS02155	COG0697	spore germination
A4U98_RS02170	COG2226	methyltransferase
A4U98_RS02180	COG2261	transglycosylase associated protein
A4U98_RS02185	COG2261	transglycosylase associated protein
A4U98_RS02200	COG2217	Heavy metal translocating P-type atpase
A4U98_RS02215	COG0343	queuine tRNA-ribosyltransferase activity
A4U98_RS02240	COG2814	Major facilitator Superfamily
A4U98_RS02275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4U98_RS02290	COG0191	fructose-bisphosphate aldolase activity
A4U98_RS02340	COG2190	(PTS) system
A4U98_RS02340	COG2211	Major facilitator Superfamily
A4U98_RS02350	COG4770	biotin carboxylase activity
A4U98_RS02385	COG1136	(ABC) transporter
A4U98_RS02390	COG1136	(ABC) transporter
A4U98_RS02390	COG0577	efflux transmembrane transporter activity
A4U98_RS02400	COG0477	Major facilitator Superfamily
A4U98_RS02465	COG0390	transport system, permease component
A4U98_RS02470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4U98_RS02475	COG1113	amino acid transport
A4U98_RS02480	COG1136	(ABC) transporter
A4U98_RS02480	COG0577	efflux transmembrane transporter activity
A4U98_RS02490	COG1113	amino acid transport
A4U98_RS02505	COG0577	efflux transmembrane transporter activity
A4U98_RS02510	COG1136	(ABC) transporter
A4U98_RS02510	COG0577	efflux transmembrane transporter activity
A4U98_RS02515	COG1846	Transcriptional regulator
A4U98_RS02535	COG3409	Peptidoglycan-binding domain 1 protein
A4U98_RS02550	COG0577	efflux transmembrane transporter activity
A4U98_RS02550	COG1136	(ABC) transporter
A4U98_RS02570	COG2197	response regulator
A4U98_RS02580	COG1125	glycine betaine transport
A4U98_RS02580	COG0517	IMP dehydrogenase activity
A4U98_RS02585	COG0671	phosphoesterase, PA-phosphatase related
A4U98_RS02590	COG0110	maltose O-acetyltransferase activity
A4U98_RS02630	COG1129	ABC transporter
A4U98_RS02635	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4U98_RS02635	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4U98_RS02665	COG1309	transcriptional regulator
A4U98_RS02685	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4U98_RS02690	COG0305	Participates in initiation and elongation during chromosome replication
A4U98_RS02695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4U98_RS02715	COG0584	glycerophosphoryl diester phosphodiesterase
A4U98_RS02730	COG0406	alpha-ribazole phosphatase activity
A4U98_RS02730	COG0494	nUDIX hydrolase
A4U98_RS02735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4U98_RS02815	COG1260	myo-inositol-1-phosphate synthase
A4U98_RS02830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4U98_RS02830	COG1754	DNA topoisomerase type I activity
A4U98_RS02960	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4U98_RS02965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4U98_RS02995	COG0668	transmembrane transport
A4U98_RS03015	COG0436	Aminotransferase
A4U98_RS03030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4U98_RS03030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4U98_RS03040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4U98_RS03045	COG2826	transposase and inactivated derivatives, IS30 family
A4U98_RS03055	COG0742	ribosomal rna small subunit methyltransferase
A4U98_RS03070	COG1837	Belongs to the UPF0109 family
A4U98_RS03105	COG0488	(ABC) transporter
A4U98_RS03115	COG0440	acetolactate synthase activity
A4U98_RS03155	COG0667	Aldo Keto reductase
A4U98_RS03220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4U98_RS03240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4U98_RS03245	COG1530	ribonuclease E activity
A4U98_RS03270	COG0436	Aminotransferase
A4U98_RS03310	COG1268	BioY protein
A4U98_RS03315	COG4770	biotin carboxylase activity
A4U98_RS03320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4U98_RS03345	COG0039	L-malate dehydrogenase activity
A4U98_RS03360	COG1704	LemA family
A4U98_RS03370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U98_RS03375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U98_RS03390	COG0656	L-ascorbic acid biosynthetic process
A4U98_RS03395	COG0826	peptidase U32
A4U98_RS03410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A4U98_RS03420	COG3579	cysteine-type endopeptidase activity
A4U98_RS03425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U98_RS03430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4U98_RS03430	COG2755	lipolytic protein G-D-S-L family
A4U98_RS03435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U98_RS03440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4U98_RS03445	COG5002	protein histidine kinase activity
A4U98_RS03450	COG0745	RESPONSE REGULATOR receiver
A4U98_RS03465	COG0581	inorganic phosphate transmembrane transporter activity
A4U98_RS03485	COG0581	inorganic phosphate transmembrane transporter activity
A4U98_RS03495	COG2252	PERMEase
A4U98_RS03540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4U98_RS03580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4U98_RS03585	COG0531	amino acid
A4U98_RS03600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4U98_RS03615	COG0745	RESPONSE REGULATOR receiver
A4U98_RS03620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U98_RS03625	COG1739	Uncharacterized protein family UPF0029
A4U98_RS03660	COG1012	belongs to the aldehyde dehydrogenase family
A4U98_RS03660	COG1454	alcohol dehydrogenase
A4U98_RS03715	COG0255	Belongs to the universal ribosomal protein uL29 family
A4U98_RS03850	COG0196	riboflavin kinase activity
A4U98_RS03870	COG0328	RNA-DNA hybrid ribonuclease activity
A4U98_RS03910	COG2197	response regulator
A4U98_RS03950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4U98_RS03975	COG3579	cysteine-type endopeptidase activity
A4U98_RS03980	COG0531	amino acid
A4U98_RS03990	COG1113	amino acid transport
A4U98_RS04005	COG4716	Myosin-crossreactive antigen
A4U98_RS04010	COG3321	synthase
A4U98_RS04010	COG1028	Short-chain dehydrogenase reductase Sdr
A4U98_RS04010	COG0604	alcohol dehydrogenase
A4U98_RS04020	COG5002	protein histidine kinase activity
A4U98_RS04025	COG0704	Plays a role in the regulation of phosphate uptake
A4U98_RS04030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4U98_RS04035	COG3942	CHAP domain
A4U98_RS04035	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4U98_RS04040	COG1388	LysM domain
A4U98_RS04040	COG0791	NLP P60 protein
A4U98_RS04060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4U98_RS04065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4U98_RS04070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4U98_RS04150	COG3189	MarR family transcriptional regulator
A4U98_RS04155	COG4932	domain protein
A4U98_RS04155	COG1388	LysM domain
A4U98_RS04165	COG3250	beta-galactosidase activity
A4U98_RS04205	COG0395	ABC-type sugar transport system, permease component
A4U98_RS04215	COG1609	Transcriptional regulator
A4U98_RS04235	COG1216	Glycosyl transferase, family 2
A4U98_RS04240	COG0628	permease
A4U98_RS04275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4U98_RS04290	COG1946	Acyl-CoA thioesterase
A4U98_RS04300	COG0242	peptide deformylase activity
A4U98_RS04305	COG2873	o-acetylhomoserine
A4U98_RS04340	COG3507	Belongs to the glycosyl hydrolase 43 family
A4U98_RS04345	COG1609	Transcriptional regulator
A4U98_RS04355	COG1175	transmembrane transport
A4U98_RS04365	COG3507	Belongs to the glycosyl hydrolase 43 family
A4U98_RS04375	COG2272	Belongs to the type-B carboxylesterase lipase family
A4U98_RS04385	COG1070	Carbohydrate kinase
A4U98_RS04410	COG0009	L-threonylcarbamoyladenylate synthase
A4U98_RS04430	COG0561	phosphatase activity
A4U98_RS04435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4U98_RS04455	COG3590	peptidase
A4U98_RS04465	COG0024	Methionine aminopeptidase
A4U98_RS04470	COG0372	Belongs to the citrate synthase family
A4U98_RS04485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4U98_RS04490	COG2884	Cell division ATP-binding protein ftsE
A4U98_RS04500	COG1388	LysM domain
A4U98_RS04500	COG3942	CHAP domain
A4U98_RS04515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U98_RS04520	COG0765	amino acid transport
A4U98_RS04545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4U98_RS04550	COG0564	pseudouridine synthase activity
A4U98_RS04565	COG0747	negative chemotaxis
A4U98_RS04570	COG0601	transmembrane transport
A4U98_RS04575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U98_RS04600	COG0514	ATP-dependent DNA helicase (RecQ)
A4U98_RS04640	COG3311	Transcriptional regulator
A4U98_RS04705	COG0371	Dehydrogenase
A4U98_RS04720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4U98_RS04725	COG0358	DNA primase activity
A4U98_RS04730	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A4U98_RS04740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4U98_RS04745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4U98_RS04750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4U98_RS04755	COG0735	belongs to the Fur family
A4U98_RS04760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A4U98_RS04765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A4U98_RS04770	COG0151	Belongs to the GarS family
A4U98_RS04785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4U98_RS04835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4U98_RS04915	COG0284	orotidine-5'-phosphate decarboxylase activity
A4U98_RS04940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4U98_RS04955	COG0560	Phosphoserine phosphatase
A4U98_RS04960	COG0586	Pfam SNARE associated Golgi protein
A4U98_RS04970	COG4122	O-methyltransferase activity
A4U98_RS05000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4U98_RS05040	COG0714	Associated with various cellular activities
A4U98_RS05055	COG1278	Cold shock
A4U98_RS05075	COG0745	RESPONSE REGULATOR receiver
A4U98_RS05080	COG2205	protein histidine kinase activity
A4U98_RS05085	COG1278	Cold shock
A4U98_RS05120	COG1196	nuclear chromosome segregation
A4U98_RS05130	COG1126	abc transporter atp-binding protein
A4U98_RS05135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U98_RS05140	COG0765	amino acid transport
A4U98_RS05145	COG0765	amino acid transport
A4U98_RS05165	COG2814	Major facilitator Superfamily
A4U98_RS05170	COG1022	Amp-dependent synthetase and ligase
A4U98_RS05195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4U98_RS05205	COG0656	L-ascorbic acid biosynthetic process
A4U98_RS05225	COG0436	Aminotransferase
A4U98_RS05230	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A4U98_RS05250	COG2151	metal-sulfur cluster biosynthetic enzyme
A4U98_RS05250	COG0489	protein tyrosine kinase activity
A4U98_RS05255	COG4721	ABC-type cobalt transport system, permease component
A4U98_RS05280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4U98_RS05305	COG4721	ABC-type cobalt transport system, permease component
A4U98_RS05315	COG1136	(ABC) transporter
A4U98_RS05320	COG0577	efflux transmembrane transporter activity
A4U98_RS05325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U98_RS05415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4U98_RS05420	COG0569	domain protein
A4U98_RS05435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U98_RS05455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4U98_RS05475	COG0799	negative regulation of ribosome biogenesis
A4U98_RS05505	COG0406	alpha-ribazole phosphatase activity
A4U98_RS05510	COG0598	Magnesium transport protein CorA
A4U98_RS05515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U98_RS05540	COG0802	atpase or kinase
A4U98_RS05595	COG0516	GMP reductase activity
A4U98_RS05605	COG1022	Amp-dependent synthetase and ligase
A4U98_RS05635	COG0575	Belongs to the CDS family
A4U98_RS05650	COG1131	(ABC) transporter
A4U98_RS05675	COG1573	uracil-dna glycosylase
A4U98_RS05695	COG0133	tryptophan synthase activity
A4U98_RS05710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4U98_RS05725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4U98_RS05745	COG1716	ATPase activity
A4U98_RS05760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4U98_RS05765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4U98_RS05815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4U98_RS05835	COG0045	succinate-CoA ligase (ADP-forming) activity
A4U98_RS05870	COG0438	transferase activity, transferring glycosyl groups
A4U98_RS05875	COG1560	Kdo2-lipid A biosynthetic process
A4U98_RS05890	COG0488	(ABC) transporter
A4U98_RS05900	COG0456	acetyltransferase
A4U98_RS05915	COG0488	(ABC) transporter
A4U98_RS05970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4U98_RS05980	COG0436	Aminotransferase
A4U98_RS05990	COG0436	Aminotransferase
A4U98_RS05995	COG0561	phosphatase activity
A4U98_RS06000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4U98_RS06025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4U98_RS06055	COG0488	(ABC) transporter
A4U98_RS06080	COG0450	alkyl hydroperoxide reductase
A4U98_RS06090	COG0583	DNA-binding transcription factor activity
A4U98_RS06130	COG0167	dihydroorotate dehydrogenase activity
A4U98_RS06135	COG0543	2 iron, 2 sulfur cluster binding
A4U98_RS06140	COG0284	orotidine-5'-phosphate decarboxylase activity
A4U98_RS06145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4U98_RS06170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4U98_RS06190	COG1119	ATPase activity
A4U98_RS06195	COG0297	glycogen (starch) synthase activity
A4U98_RS06215	COG0067	glutamate synthase
A4U98_RS06215	COG0070	glutamate synthase
A4U98_RS06215	COG0069	glutamate synthase activity
A4U98_RS06235	COG2860	membrane
A4U98_RS06240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4U98_RS06265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4U98_RS06290	COG1702	phosphate starvation-inducible protein PhoH
A4U98_RS06295	COG0537	adenosine 5'-monophosphoramidase activity
A4U98_RS06300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4U98_RS06320	COG2151	metal-sulfur cluster biosynthetic enzyme
A4U98_RS06325	COG0822	iron-sulfur transferase activity
A4U98_RS06335	COG0396	ATPase activity
A4U98_RS06340	COG0719	Fe-S assembly protein
A4U98_RS06350	COG1376	ErfK ybiS ycfS ynhG family protein
A4U98_RS06365	COG1523	belongs to the glycosyl hydrolase 13 family
A4U98_RS06385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4U98_RS06430	COG0588	phosphoglycerate mutase activity
A4U98_RS06435	COG1950	PFAM Membrane protein of
A4U98_RS06465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4U98_RS06480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4U98_RS06485	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
A4U98_RS06495	COG1131	(ABC) transporter
A4U98_RS06500	COG1725	Transcriptional regulator
A4U98_RS06510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4U98_RS06535	COG0563	adenylate kinase activity
A4U98_RS06560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4U98_RS06590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4U98_RS06605	COG0494	nUDIX hydrolase
A4U98_RS06615	COG0469	pyruvate kinase activity
A4U98_RS06645	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4U98_RS06650	COG1121	(ABC) transporter
A4U98_RS06665	COG1329	Transcriptional regulator
A4U98_RS06675	COG0745	RESPONSE REGULATOR receiver
A4U98_RS06680	COG2205	protein histidine kinase activity
A4U98_RS06710	COG1316	TRANSCRIPTIONal
A4U98_RS06715	COG1316	TRANSCRIPTIONal
A4U98_RS06740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4U98_RS06750	COG1760	l-serine dehydratase
A4U98_RS06795	COG1116	anion transmembrane transporter activity
A4U98_RS06830	COG1966	Carbon starvation protein
A4U98_RS06835	COG1132	(ABC) transporter
A4U98_RS06840	COG1116	anion transmembrane transporter activity
A4U98_RS06865	COG1918	ferrous iron import across plasma membrane
A4U98_RS06865	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4U98_RS06885	COG0363	glucosamine-6-phosphate deaminase activity
A4U98_RS06890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4U98_RS06895	COG3340	Belongs to the peptidase S51 family
A4U98_RS06900	COG1114	Component of the transport system for branched-chain amino acids
A4U98_RS06920	COG0513	Belongs to the DEAD box helicase family
A4U98_RS06930	COG2233	PERMEase
A4U98_RS06950	COG0012	GTP binding
A4U98_RS06955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4U98_RS06965	COG4585	Histidine kinase
A4U98_RS06970	COG2197	response regulator
A4U98_RS06980	COG1136	(ABC) transporter
A4U98_RS06980	COG0577	efflux transmembrane transporter activity
A4U98_RS06990	COG1122	ATPase activity
A4U98_RS06995	COG2873	o-acetylhomoserine
A4U98_RS07020	COG1053	succinate dehydrogenase
A4U98_RS07090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4U98_RS07095	COG1882	Formate acetyltransferase
A4U98_RS07110	COG1473	amidohydrolase
A4U98_RS07115	COG2011	ABC-type metal ion transport system permease component
A4U98_RS07125	COG1464	Belongs to the NlpA lipoprotein family
A4U98_RS07135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4U98_RS07160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4U98_RS07170	COG1201	RNA secondary structure unwinding
A4U98_RS07190	COG0438	transferase activity, transferring glycosyl groups
A4U98_RS07195	COG0187	DNA topoisomerase II activity
A4U98_RS07200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4U98_RS07210	COG0142	geranyltranstransferase activity
A4U98_RS07230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4U98_RS07240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4U98_RS07265	COG1396	sequence-specific DNA binding
A4U98_RS07270	COG1058	Belongs to the CinA family
A4U98_RS07270	COG1546	Belongs to the CinA family
A4U98_RS07275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4U98_RS07295	COG2357	RelA SpoT domain protein
A4U98_RS07300	COG0670	Belongs to the BI1 family
A4U98_RS07305	COG3804	dihydrodipicolinate reductase
A4U98_RS07320	COG1131	(ABC) transporter
A4U98_RS07325	COG4585	Histidine kinase
A4U98_RS07330	COG2197	response regulator
A4U98_RS07340	COG0110	maltose O-acetyltransferase activity
A4U98_RS07350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4U98_RS07380	COG0708	Exodeoxyribonuclease III
A4U98_RS07395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U98_RS07400	COG0601	transmembrane transport
A4U98_RS07420	COG0577	efflux transmembrane transporter activity
A4U98_RS07420	COG1136	(ABC) transporter
A4U98_RS07425	COG0577	efflux transmembrane transporter activity