locus-tag	class	description
A4U98_RS00005	COG0358	DNA primase activity
A4U98_RS00010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4U98_RS00025	COG0371	Dehydrogenase
A4U98_RS00090	COG3311	Transcriptional regulator
A4U98_RS00130	COG0514	ATP-dependent DNA helicase (RecQ)
A4U98_RS00155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U98_RS00160	COG0601	transmembrane transport
A4U98_RS00165	COG0747	negative chemotaxis
A4U98_RS00180	COG0564	pseudouridine synthase activity
A4U98_RS00185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4U98_RS00210	COG0765	amino acid transport
A4U98_RS00215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U98_RS00235	COG1388	LysM domain
A4U98_RS00235	COG3942	CHAP domain
A4U98_RS00245	COG2884	Cell division ATP-binding protein ftsE
A4U98_RS00250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4U98_RS00270	COG0372	Belongs to the citrate synthase family
A4U98_RS00275	COG0024	Methionine aminopeptidase
A4U98_RS00285	COG3590	peptidase
A4U98_RS00305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4U98_RS00310	COG0561	phosphatase activity
A4U98_RS00330	COG0009	L-threonylcarbamoyladenylate synthase
A4U98_RS00355	COG1070	Carbohydrate kinase
A4U98_RS00365	COG2272	Belongs to the type-B carboxylesterase lipase family
A4U98_RS00375	COG3507	Belongs to the glycosyl hydrolase 43 family
A4U98_RS00385	COG1175	transmembrane transport
A4U98_RS00395	COG1609	Transcriptional regulator
A4U98_RS00400	COG3507	Belongs to the glycosyl hydrolase 43 family
A4U98_RS00435	COG2873	o-acetylhomoserine
A4U98_RS00440	COG0242	peptide deformylase activity
A4U98_RS00450	COG1946	Acyl-CoA thioesterase
A4U98_RS00465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4U98_RS00500	COG0628	permease
A4U98_RS00505	COG1216	Glycosyl transferase, family 2
A4U98_RS00525	COG1609	Transcriptional regulator
A4U98_RS00535	COG0395	ABC-type sugar transport system, permease component
A4U98_RS00580	COG3250	beta-galactosidase activity
A4U98_RS00590	COG4932	domain protein
A4U98_RS00590	COG1388	LysM domain
A4U98_RS00595	COG3189	MarR family transcriptional regulator
A4U98_RS00675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4U98_RS00680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4U98_RS00685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4U98_RS00705	COG1388	LysM domain
A4U98_RS00705	COG0791	NLP P60 protein
A4U98_RS00710	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4U98_RS00710	COG3942	CHAP domain
A4U98_RS00715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4U98_RS00720	COG0704	Plays a role in the regulation of phosphate uptake
A4U98_RS00725	COG5002	protein histidine kinase activity
A4U98_RS00735	COG0604	alcohol dehydrogenase
A4U98_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
A4U98_RS00735	COG3321	synthase
A4U98_RS00740	COG4716	Myosin-crossreactive antigen
A4U98_RS00755	COG1113	amino acid transport
A4U98_RS00765	COG0531	amino acid
A4U98_RS00770	COG3579	cysteine-type endopeptidase activity
A4U98_RS00800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4U98_RS00835	COG2197	response regulator
A4U98_RS00885	COG0328	RNA-DNA hybrid ribonuclease activity
A4U98_RS00910	COG0196	riboflavin kinase activity
A4U98_RS01050	COG0255	Belongs to the universal ribosomal protein uL29 family
A4U98_RS01105	COG1454	alcohol dehydrogenase
A4U98_RS01105	COG1012	belongs to the aldehyde dehydrogenase family
A4U98_RS01140	COG1739	Uncharacterized protein family UPF0029
A4U98_RS01145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U98_RS01150	COG0745	RESPONSE REGULATOR receiver
A4U98_RS01165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4U98_RS01180	COG0531	amino acid
A4U98_RS01185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4U98_RS01225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4U98_RS01270	COG2252	PERMEase
A4U98_RS01280	COG0581	inorganic phosphate transmembrane transporter activity
A4U98_RS01300	COG0581	inorganic phosphate transmembrane transporter activity
A4U98_RS01315	COG0745	RESPONSE REGULATOR receiver
A4U98_RS01320	COG5002	protein histidine kinase activity
A4U98_RS01325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4U98_RS01330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U98_RS01335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4U98_RS01335	COG2755	lipolytic protein G-D-S-L family
A4U98_RS01340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U98_RS01345	COG3579	cysteine-type endopeptidase activity
A4U98_RS01355	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A4U98_RS01375	COG0826	peptidase U32
A4U98_RS01380	COG0656	L-ascorbic acid biosynthetic process
A4U98_RS01395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U98_RS01400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U98_RS01410	COG1704	LemA family
A4U98_RS01425	COG0039	L-malate dehydrogenase activity
A4U98_RS01450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4U98_RS01455	COG4770	biotin carboxylase activity
A4U98_RS01460	COG1268	BioY protein
A4U98_RS01500	COG0436	Aminotransferase
A4U98_RS01535	COG1530	ribonuclease E activity
A4U98_RS01540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4U98_RS01560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4U98_RS01630	COG0667	Aldo Keto reductase
A4U98_RS01670	COG0440	acetolactate synthase activity
A4U98_RS01680	COG0488	(ABC) transporter
A4U98_RS01720	COG1837	Belongs to the UPF0109 family
A4U98_RS01735	COG0742	ribosomal rna small subunit methyltransferase
A4U98_RS01810	COG2826	transposase and inactivated derivatives, IS30 family
A4U98_RS01815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4U98_RS01825	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4U98_RS01825	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4U98_RS01840	COG0436	Aminotransferase
A4U98_RS01860	COG0668	transmembrane transport
A4U98_RS01895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4U98_RS01905	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4U98_RS02040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4U98_RS02040	COG1754	DNA topoisomerase type I activity
A4U98_RS02055	COG1260	myo-inositol-1-phosphate synthase
A4U98_RS02135	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4U98_RS02140	COG0494	nUDIX hydrolase
A4U98_RS02140	COG0406	alpha-ribazole phosphatase activity
A4U98_RS02160	COG0584	glycerophosphoryl diester phosphodiesterase
A4U98_RS02180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4U98_RS02185	COG0305	Participates in initiation and elongation during chromosome replication
A4U98_RS02190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4U98_RS02210	COG1309	transcriptional regulator
A4U98_RS02240	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4U98_RS02240	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4U98_RS02245	COG1129	ABC transporter
A4U98_RS02290	COG0110	maltose O-acetyltransferase activity
A4U98_RS02295	COG0671	phosphoesterase, PA-phosphatase related
A4U98_RS02300	COG0517	IMP dehydrogenase activity
A4U98_RS02300	COG1125	glycine betaine transport
A4U98_RS02310	COG2197	response regulator
A4U98_RS02330	COG1136	(ABC) transporter
A4U98_RS02330	COG0577	efflux transmembrane transporter activity
A4U98_RS02345	COG3409	Peptidoglycan-binding domain 1 protein
A4U98_RS02365	COG1846	Transcriptional regulator
A4U98_RS02375	COG0577	efflux transmembrane transporter activity
A4U98_RS02390	COG1113	amino acid transport
A4U98_RS02400	COG1136	(ABC) transporter
A4U98_RS02400	COG0577	efflux transmembrane transporter activity
A4U98_RS02405	COG1113	amino acid transport
A4U98_RS02410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4U98_RS02415	COG0390	transport system, permease component
A4U98_RS02480	COG0477	Major facilitator Superfamily
A4U98_RS02490	COG1136	(ABC) transporter
A4U98_RS02490	COG0577	efflux transmembrane transporter activity
A4U98_RS02495	COG1136	(ABC) transporter
A4U98_RS02530	COG4770	biotin carboxylase activity
A4U98_RS02540	COG2190	(PTS) system
A4U98_RS02540	COG2211	Major facilitator Superfamily
A4U98_RS02595	COG0191	fructose-bisphosphate aldolase activity
A4U98_RS02610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4U98_RS02650	COG2814	Major facilitator Superfamily
A4U98_RS02675	COG0343	queuine tRNA-ribosyltransferase activity
A4U98_RS02690	COG2217	Heavy metal translocating P-type atpase
A4U98_RS02710	COG2261	transglycosylase associated protein
A4U98_RS02715	COG2261	transglycosylase associated protein
A4U98_RS02725	COG2226	methyltransferase
A4U98_RS02740	COG0697	spore germination
A4U98_RS02775	COG0768	penicillin binding
A4U98_RS02780	COG0515	serine threonine protein kinase
A4U98_RS02795	COG3764	Sortase (surface protein transpeptidase)
A4U98_RS02835	COG0058	SHG alpha-glucan phosphorylase activity
A4U98_RS02855	COG0180	Tryptophanyl-tRNA synthetase
A4U98_RS02865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A4U98_RS02870	COG0656	L-ascorbic acid biosynthetic process
A4U98_RS02890	COG3534	alpha-L-arabinofuranosidase
A4U98_RS02895	COG1609	Transcriptional regulator
A4U98_RS02910	COG1940	carbohydrate kinase activity
A4U98_RS02910	COG1846	Transcriptional regulator
A4U98_RS02925	COG4214	carbohydrate transport
A4U98_RS02940	COG1609	Transcriptional regulator
A4U98_RS02945	COG0288	reversible hydration of carbon dioxide
A4U98_RS02950	COG1253	flavin adenine dinucleotide binding
A4U98_RS02955	COG0783	Belongs to the Dps family
A4U98_RS02960	COG3231	kanamycin kinase activity
A4U98_RS02965	COG1472	Belongs to the glycosyl hydrolase 3 family
A4U98_RS03060	COG2226	methyltransferase
A4U98_RS03065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4U98_RS03110	COG1970	mechanosensitive ion channel activity
A4U98_RS03125	COG2814	Major facilitator Superfamily
A4U98_RS03130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4U98_RS03135	COG1272	protein, Hemolysin III
A4U98_RS03150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4U98_RS03155	COG0187	DNA topoisomerase II activity
A4U98_RS03170	COG0592	DNA-directed DNA polymerase activity
A4U98_RS03200	COG1847	R3H domain protein
A4U98_RS03210	COG1192	Involved in chromosome partitioning
A4U98_RS03215	COG1475	DNA binding
A4U98_RS03220	COG0492	ferredoxin-NADP+ reductase activity
A4U98_RS03240	COG0617	tRNA 3'-terminal CCA addition
A4U98_RS03260	COG3583	domain protein
A4U98_RS03280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4U98_RS03285	COG3842	ATPase activity
A4U98_RS03295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U98_RS03300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U98_RS03310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4U98_RS03330	COG0025	NhaP-type Na H and K H
A4U98_RS03335	COG0590	tRNA wobble adenosine to inosine editing
A4U98_RS03335	COG0037	tRNA processing
A4U98_RS03355	COG1175	transmembrane transport
A4U98_RS03360	COG0395	ABC-type sugar transport system, permease component
A4U98_RS03380	COG0366	Alpha amylase catalytic
A4U98_RS03390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4U98_RS03395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4U98_RS03400	COG1609	Transcriptional regulator
A4U98_RS03475	COG0477	Major facilitator Superfamily
A4U98_RS03485	COG0778	Nitroreductase
A4U98_RS03500	COG0366	Alpha amylase catalytic
A4U98_RS03505	COG2182	Extracellular solute-binding protein
A4U98_RS03510	COG1609	Transcriptional regulator
A4U98_RS03550	COG1175	transmembrane transport
A4U98_RS03555	COG3833	ABC-type maltose transport systems, permease component
A4U98_RS03560	COG1523	belongs to the glycosyl hydrolase 13 family
A4U98_RS03565	COG0546	phosphoglycolate phosphatase activity
A4U98_RS03575	COG1609	Transcriptional regulator
A4U98_RS03595	COG0484	heat shock protein binding
A4U98_RS03600	COG0789	Transcriptional regulator
A4U98_RS03610	COG3041	Addiction module toxin RelE StbE family
A4U98_RS03620	COG1309	transcriptional regulator
A4U98_RS03640	COG0586	Pfam SNARE associated Golgi protein
A4U98_RS03700	COG0084	hydrolase, TatD family'
A4U98_RS03775	COG1216	Glycosyl transferase, family 2
A4U98_RS03780	COG1368	sulfuric ester hydrolase activity
A4U98_RS03785	COG1368	sulfuric ester hydrolase activity
A4U98_RS03790	COG1215	transferase activity, transferring glycosyl groups
A4U98_RS03830	COG1609	Transcriptional regulator
A4U98_RS03845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U98_RS04025	COG1388	LysM domain
A4U98_RS04025	COG3942	CHAP domain
A4U98_RS04075	COG3843	relaxase mobilization nuclease domain protein
A4U98_RS04100	COG3550	peptidyl-serine autophosphorylation
A4U98_RS04115	COG2184	nucleotidyltransferase activity
A4U98_RS04130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4U98_RS04145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4U98_RS04150	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4U98_RS04160	COG2217	Heavy metal translocating P-type atpase
A4U98_RS04225	COG0287	Prephenate dehydrogenase
A4U98_RS04225	COG1605	Chorismate mutase
A4U98_RS04240	COG0747	negative chemotaxis
A4U98_RS04255	COG0745	RESPONSE REGULATOR receiver
A4U98_RS04265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4U98_RS04290	COG0028	Belongs to the TPP enzyme family
A4U98_RS04295	COG0679	Auxin Efflux Carrier
A4U98_RS04325	COG0356	it plays a direct role in the translocation of protons across the membrane
A4U98_RS04360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4U98_RS04370	COG0545	Peptidyl-prolyl cis-trans isomerase
A4U98_RS04400	COG0395	ABC-type sugar transport system, permease component
A4U98_RS04405	COG0251	oxidation-reduction process
A4U98_RS04420	COG0019	diaminopimelate decarboxylase activity
A4U98_RS04425	COG0460	homoserine dehydrogenase
A4U98_RS04430	COG0083	homoserine kinase activity
A4U98_RS04450	COG1857	crispr-associated protein
A4U98_RS04465	COG1518	maintenance of DNA repeat elements
A4U98_RS04470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4U98_RS04510	COG0489	protein tyrosine kinase activity
A4U98_RS04520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4U98_RS04535	COG4988	ABC transporter
A4U98_RS04545	COG0463	Glycosyl transferase, family 2
A4U98_RS04545	COG1216	Glycosyl transferase, family 2
A4U98_RS04560	COG3475	LICD family
A4U98_RS04575	COG2826	transposase and inactivated derivatives, IS30 family
A4U98_RS04595	COG1215	transferase activity, transferring glycosyl groups
A4U98_RS04600	COG3328	transposase activity
A4U98_RS04615	COG4750	Nucleotidyl transferase
A4U98_RS04620	COG0438	transferase activity, transferring glycosyl groups
A4U98_RS04675	COG1216	Glycosyl transferase, family 2
A4U98_RS04690	COG2244	polysaccharide biosynthetic process
A4U98_RS04695	COG0438	transferase activity, transferring glycosyl groups
A4U98_RS04705	COG1368	sulfuric ester hydrolase activity
A4U98_RS04730	COG0395	ABC-type sugar transport system, permease component
A4U98_RS04740	COG1609	Transcriptional regulator
A4U98_RS04755	COG2814	Major facilitator Superfamily
A4U98_RS04765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4U98_RS04790	COG1088	dTDP-glucose 4,6-dehydratase activity
A4U98_RS04815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4U98_RS04860	COG0095	Lipoate-protein ligase
A4U98_RS04870	COG4499	WXG100 protein secretion system (Wss), protein YukC
A4U98_RS04870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4U98_RS04875	COG1902	pentaerythritol trinitrate reductase activity
A4U98_RS04880	COG0167	dihydroorotate dehydrogenase activity
A4U98_RS04885	COG1216	Glycosyl transferase, family 2
A4U98_RS04890	COG1349	DNA-binding transcription factor activity
A4U98_RS04900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4U98_RS04920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4U98_RS04925	COG1194	a g-specific adenine glycosylase
A4U98_RS04965	COG0714	Associated with various cellular activities
A4U98_RS04980	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A4U98_RS04985	COG0210	DNA helicase
A4U98_RS05010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4U98_RS05045	COG0436	Aminotransferase
A4U98_RS05065	COG1722	exodeoxyribonuclease VII activity
A4U98_RS05070	COG1570	exodeoxyribonuclease VII activity
A4U98_RS05075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4U98_RS05075	COG1328	CTP reductase activity
A4U98_RS05110	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A4U98_RS05125	COG1132	(ABC) transporter
A4U98_RS05130	COG1132	(ABC) transporter
A4U98_RS05170	COG1842	Phage shock protein A
A4U98_RS05175	COG2814	Major facilitator Superfamily
A4U98_RS05205	COG4166	transmembrane transport
A4U98_RS05255	COG2176	DNA-directed DNA polymerase activity
A4U98_RS05265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4U98_RS05270	COG1464	Belongs to the NlpA lipoprotein family
A4U98_RS05280	COG2011	ABC-type metal ion transport system permease component
A4U98_RS05290	COG0436	Aminotransferase
A4U98_RS05295	COG0765	amino acid transport
A4U98_RS05300	COG0765	amino acid transport
A4U98_RS05305	COG1126	abc transporter atp-binding protein
A4U98_RS05330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4U98_RS05340	COG0613	PHP domain protein
A4U98_RS05365	COG3480	Lon protease (S16) C-terminal proteolytic domain
A4U98_RS05420	COG1957	nucleoside hydrolase
A4U98_RS05425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U98_RS05430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U98_RS05480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4U98_RS05515	COG0587	DNA-directed DNA polymerase activity
A4U98_RS05560	COG1643	Atp-dependent helicase
A4U98_RS05570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4U98_RS05580	COG1230	cation diffusion facilitator family transporter
A4U98_RS05600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U98_RS05625	COG0768	penicillin binding
A4U98_RS05635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4U98_RS05675	COG0601	transmembrane transport
A4U98_RS05715	COG2816	NAD+ diphosphatase activity
A4U98_RS05720	COG0006	proline dipeptidase activity
A4U98_RS05755	COG1396	sequence-specific DNA binding
A4U98_RS05780	COG2197	response regulator
A4U98_RS05785	COG0285	dihydrofolate synthase activity
A4U98_RS05810	COG2017	converts alpha-aldose to the beta-anomer
A4U98_RS05820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4U98_RS05835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4U98_RS05865	COG0477	Major facilitator Superfamily
A4U98_RS05870	COG1217	gtp-binding protein TYPA
A4U98_RS05885	COG0287	Prephenate dehydrogenase
A4U98_RS05895	COG0577	efflux transmembrane transporter activity
A4U98_RS05900	COG0577	efflux transmembrane transporter activity
A4U98_RS05900	COG1136	(ABC) transporter
A4U98_RS05920	COG0601	transmembrane transport
A4U98_RS05925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U98_RS05940	COG0708	Exodeoxyribonuclease III
A4U98_RS05970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4U98_RS05980	COG0110	maltose O-acetyltransferase activity
A4U98_RS05990	COG2197	response regulator
A4U98_RS05995	COG4585	Histidine kinase
A4U98_RS06000	COG1131	(ABC) transporter
A4U98_RS06015	COG3804	dihydrodipicolinate reductase
A4U98_RS06020	COG0670	Belongs to the BI1 family
A4U98_RS06025	COG2357	RelA SpoT domain protein
A4U98_RS06045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4U98_RS06050	COG1546	Belongs to the CinA family
A4U98_RS06050	COG1058	Belongs to the CinA family
A4U98_RS06055	COG1396	sequence-specific DNA binding
A4U98_RS06080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4U98_RS06090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4U98_RS06110	COG0142	geranyltranstransferase activity
A4U98_RS06120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4U98_RS06125	COG0187	DNA topoisomerase II activity
A4U98_RS06130	COG0438	transferase activity, transferring glycosyl groups
A4U98_RS06150	COG1201	RNA secondary structure unwinding
A4U98_RS06160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4U98_RS06185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4U98_RS06195	COG1464	Belongs to the NlpA lipoprotein family
A4U98_RS06205	COG2011	ABC-type metal ion transport system permease component
A4U98_RS06210	COG1473	amidohydrolase
A4U98_RS06225	COG1882	Formate acetyltransferase
A4U98_RS06230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4U98_RS06300	COG1053	succinate dehydrogenase
A4U98_RS06325	COG2873	o-acetylhomoserine
A4U98_RS06330	COG1122	ATPase activity
A4U98_RS06340	COG0577	efflux transmembrane transporter activity
A4U98_RS06340	COG1136	(ABC) transporter
A4U98_RS06350	COG2197	response regulator
A4U98_RS06355	COG4585	Histidine kinase
A4U98_RS06365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4U98_RS06370	COG0012	GTP binding
A4U98_RS06390	COG2233	PERMEase
A4U98_RS06400	COG0513	Belongs to the DEAD box helicase family
A4U98_RS06420	COG1114	Component of the transport system for branched-chain amino acids
A4U98_RS06425	COG3340	Belongs to the peptidase S51 family
A4U98_RS06430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4U98_RS06435	COG0363	glucosamine-6-phosphate deaminase activity
A4U98_RS06460	COG1918	ferrous iron import across plasma membrane
A4U98_RS06460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4U98_RS06485	COG1116	anion transmembrane transporter activity
A4U98_RS06490	COG1132	(ABC) transporter
A4U98_RS06495	COG1966	Carbon starvation protein
A4U98_RS06530	COG1116	anion transmembrane transporter activity
A4U98_RS06575	COG1760	l-serine dehydratase
A4U98_RS06585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4U98_RS06610	COG1316	TRANSCRIPTIONal
A4U98_RS06615	COG1316	TRANSCRIPTIONal
A4U98_RS06645	COG2205	protein histidine kinase activity
A4U98_RS06650	COG0745	RESPONSE REGULATOR receiver
A4U98_RS06660	COG1329	Transcriptional regulator
A4U98_RS06675	COG1121	(ABC) transporter
A4U98_RS06680	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4U98_RS06710	COG0469	pyruvate kinase activity
A4U98_RS06720	COG0494	nUDIX hydrolase
A4U98_RS06735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4U98_RS06765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4U98_RS06790	COG0563	adenylate kinase activity
A4U98_RS06815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4U98_RS06825	COG1725	Transcriptional regulator
A4U98_RS06830	COG1131	(ABC) transporter
A4U98_RS06840	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
A4U98_RS06845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4U98_RS06860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4U98_RS06895	COG1950	PFAM Membrane protein of
A4U98_RS06900	COG0588	phosphoglycerate mutase activity
A4U98_RS06945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4U98_RS06960	COG1376	ErfK ybiS ycfS ynhG family protein
A4U98_RS06970	COG0719	Fe-S assembly protein
A4U98_RS06975	COG0396	ATPase activity
A4U98_RS06985	COG0822	iron-sulfur transferase activity
A4U98_RS06990	COG2151	metal-sulfur cluster biosynthetic enzyme
A4U98_RS07010	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4U98_RS07015	COG0537	adenosine 5'-monophosphoramidase activity
A4U98_RS07020	COG1702	phosphate starvation-inducible protein PhoH
A4U98_RS07045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4U98_RS07070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4U98_RS07075	COG2860	membrane
A4U98_RS07095	COG0070	glutamate synthase
A4U98_RS07095	COG0067	glutamate synthase
A4U98_RS07095	COG0069	glutamate synthase activity
A4U98_RS07115	COG0297	glycogen (starch) synthase activity
A4U98_RS07120	COG1119	ATPase activity
A4U98_RS07140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4U98_RS07165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4U98_RS07170	COG0284	orotidine-5'-phosphate decarboxylase activity
A4U98_RS07175	COG0543	2 iron, 2 sulfur cluster binding
A4U98_RS07180	COG0167	dihydroorotate dehydrogenase activity
A4U98_RS07220	COG0583	DNA-binding transcription factor activity
A4U98_RS07230	COG0450	alkyl hydroperoxide reductase
A4U98_RS07255	COG0488	(ABC) transporter
A4U98_RS07285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4U98_RS07310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4U98_RS07315	COG0561	phosphatase activity
A4U98_RS07320	COG0436	Aminotransferase
A4U98_RS07330	COG0436	Aminotransferase
A4U98_RS07340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4U98_RS07395	COG0488	(ABC) transporter
A4U98_RS07410	COG0456	acetyltransferase
A4U98_RS07420	COG0488	(ABC) transporter
A4U98_RS07435	COG1560	Kdo2-lipid A biosynthetic process
A4U98_RS07440	COG0438	transferase activity, transferring glycosyl groups
A4U98_RS07475	COG0045	succinate-CoA ligase (ADP-forming) activity
A4U98_RS07500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4U98_RS07550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4U98_RS07555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4U98_RS07570	COG1716	ATPase activity
A4U98_RS07590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4U98_RS07605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4U98_RS07620	COG0133	tryptophan synthase activity
A4U98_RS07640	COG1573	uracil-dna glycosylase
A4U98_RS07665	COG1131	(ABC) transporter
A4U98_RS07680	COG0575	Belongs to the CDS family
A4U98_RS07710	COG1022	Amp-dependent synthetase and ligase
A4U98_RS07720	COG0516	GMP reductase activity
A4U98_RS07780	COG0802	atpase or kinase
A4U98_RS07805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U98_RS07810	COG0598	Magnesium transport protein CorA
A4U98_RS07815	COG0406	alpha-ribazole phosphatase activity
A4U98_RS07845	COG0799	negative regulation of ribosome biogenesis
A4U98_RS07865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4U98_RS07885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U98_RS07900	COG0569	domain protein
A4U98_RS07905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4U98_RS07995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U98_RS08000	COG0577	efflux transmembrane transporter activity
A4U98_RS08005	COG1136	(ABC) transporter
A4U98_RS08015	COG4721	ABC-type cobalt transport system, permease component
A4U98_RS08045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4U98_RS08070	COG4721	ABC-type cobalt transport system, permease component
A4U98_RS08075	COG2151	metal-sulfur cluster biosynthetic enzyme
A4U98_RS08075	COG0489	protein tyrosine kinase activity
A4U98_RS08095	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A4U98_RS08100	COG0436	Aminotransferase
A4U98_RS08120	COG0656	L-ascorbic acid biosynthetic process
A4U98_RS08130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4U98_RS08155	COG1022	Amp-dependent synthetase and ligase
A4U98_RS08160	COG2814	Major facilitator Superfamily
A4U98_RS08180	COG0765	amino acid transport
A4U98_RS08185	COG0765	amino acid transport
A4U98_RS08190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U98_RS08195	COG1126	abc transporter atp-binding protein
A4U98_RS08205	COG1196	nuclear chromosome segregation
A4U98_RS08240	COG1278	Cold shock
A4U98_RS08245	COG2205	protein histidine kinase activity
A4U98_RS08250	COG0745	RESPONSE REGULATOR receiver
A4U98_RS08270	COG1278	Cold shock
A4U98_RS08285	COG0714	Associated with various cellular activities
A4U98_RS08325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4U98_RS08355	COG4122	O-methyltransferase activity
A4U98_RS08365	COG0586	Pfam SNARE associated Golgi protein
A4U98_RS08370	COG0560	Phosphoserine phosphatase
A4U98_RS08385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4U98_RS08410	COG0284	orotidine-5'-phosphate decarboxylase activity
A4U98_RS08490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4U98_RS08540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4U98_RS08555	COG0151	Belongs to the GarS family
A4U98_RS08560	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A4U98_RS08565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A4U98_RS08570	COG0735	belongs to the Fur family
A4U98_RS08575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4U98_RS08580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4U98_RS08585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4U98_RS08595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump