locus-tag	class	description
BLA_RS00010	COG0592	DNA-directed DNA polymerase activity
BLA_RS00025	COG0187	DNA topoisomerase II activity
BLA_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BLA_RS00045	COG1272	protein, Hemolysin III
BLA_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BLA_RS00055	COG2814	Major facilitator Superfamily
BLA_RS00070	COG1970	mechanosensitive ion channel activity
BLA_RS00110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BLA_RS00115	COG2226	methyltransferase
BLA_RS00220	COG0583	DNA-binding transcription factor activity
BLA_RS00235	COG3231	kanamycin kinase activity
BLA_RS00275	COG0783	Belongs to the Dps family
BLA_RS00280	COG1253	flavin adenine dinucleotide binding
BLA_RS00285	COG0288	reversible hydration of carbon dioxide
BLA_RS00290	COG1609	Transcriptional regulator
BLA_RS00315	COG1609	Transcriptional regulator
BLA_RS00320	COG3534	alpha-L-arabinofuranosidase
BLA_RS00340	COG0656	L-ascorbic acid biosynthetic process
BLA_RS00345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BLA_RS00360	COG0180	Tryptophanyl-tRNA synthetase
BLA_RS00375	COG0058	SHG alpha-glucan phosphorylase activity
BLA_RS00405	COG3764	Sortase (surface protein transpeptidase)
BLA_RS00420	COG0515	serine threonine protein kinase
BLA_RS00425	COG0768	penicillin binding
BLA_RS00455	COG0697	spore germination
BLA_RS00470	COG2226	methyltransferase
BLA_RS00475	COG2261	transglycosylase associated protein
BLA_RS00480	COG2261	transglycosylase associated protein
BLA_RS00495	COG2217	Heavy metal translocating P-type atpase
BLA_RS00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLA_RS00515	COG0343	queuine tRNA-ribosyltransferase activity
BLA_RS00540	COG2814	Major facilitator Superfamily
BLA_RS00555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BLA_RS00585	COG0667	Aldo Keto reductase
BLA_RS00620	COG1063	alcohol dehydrogenase
BLA_RS00625	COG0583	DNA-binding transcription factor activity
BLA_RS00635	COG0191	fructose-bisphosphate aldolase activity
BLA_RS00645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BLA_RS00695	COG2211	Major facilitator Superfamily
BLA_RS00705	COG4770	biotin carboxylase activity
BLA_RS00735	COG0477	Major facilitator Superfamily
BLA_RS00785	COG1132	(ABC) transporter
BLA_RS00790	COG0390	transport system, permease component
BLA_RS00795	COG1113	amino acid transport
BLA_RS00800	COG1136	(ABC) transporter
BLA_RS00800	COG0577	efflux transmembrane transporter activity
BLA_RS00810	COG1113	amino acid transport
BLA_RS00825	COG0577	efflux transmembrane transporter activity
BLA_RS00830	COG1136	(ABC) transporter
BLA_RS00830	COG0577	efflux transmembrane transporter activity
BLA_RS00835	COG1846	Transcriptional regulator
BLA_RS00855	COG0671	phosphoesterase, PA-phosphatase related
BLA_RS00860	COG0110	maltose O-acetyltransferase activity
BLA_RS00900	COG1129	ABC transporter
BLA_RS00935	COG1309	transcriptional regulator
BLA_RS00955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BLA_RS00965	COG0305	Participates in initiation and elongation during chromosome replication
BLA_RS00970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BLA_RS01005	COG0494	nUDIX hydrolase
BLA_RS01005	COG0406	alpha-ribazole phosphatase activity
BLA_RS01090	COG1260	myo-inositol-1-phosphate synthase
BLA_RS01100	COG1754	DNA topoisomerase type I activity
BLA_RS01100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BLA_RS01160	COG0406	alpha-ribazole phosphatase activity
BLA_RS01215	COG0446	pyridine nucleotide-disulphide oxidoreductase
BLA_RS01220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BLA_RS01270	COG0436	Aminotransferase
BLA_RS01285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BLA_RS01285	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BLA_RS01295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BLA_RS01310	COG0742	ribosomal rna small subunit methyltransferase
BLA_RS01325	COG1837	Belongs to the UPF0109 family
BLA_RS01360	COG0488	(ABC) transporter
BLA_RS01370	COG0440	acetolactate synthase activity
BLA_RS01410	COG0667	Aldo Keto reductase
BLA_RS01475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BLA_RS01495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BLA_RS01500	COG1530	ribonuclease E activity
BLA_RS01525	COG0436	Aminotransferase
BLA_RS01560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BLA_RS01560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BLA_RS01565	COG1268	BioY protein
BLA_RS01570	COG4770	biotin carboxylase activity
BLA_RS01575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BLA_RS01600	COG0039	L-malate dehydrogenase activity
BLA_RS01615	COG1704	LemA family
BLA_RS01625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BLA_RS01630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BLA_RS01650	COG0826	peptidase U32
BLA_RS01665	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BLA_RS01675	COG3579	cysteine-type endopeptidase activity
BLA_RS01680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BLA_RS01685	COG2755	lipolytic protein G-D-S-L family
BLA_RS01685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BLA_RS01690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BLA_RS01695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BLA_RS01705	COG0745	RESPONSE REGULATOR receiver
BLA_RS01720	COG0581	inorganic phosphate transmembrane transporter activity
BLA_RS01730	COG2252	PERMEase
BLA_RS01815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BLA_RS01820	COG0531	amino acid
BLA_RS01835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BLA_RS01845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BLA_RS01850	COG1739	Uncharacterized protein family UPF0029
BLA_RS01885	COG1012	belongs to the aldehyde dehydrogenase family
BLA_RS01885	COG1454	alcohol dehydrogenase
BLA_RS01945	COG0255	Belongs to the universal ribosomal protein uL29 family
BLA_RS02075	COG0196	riboflavin kinase activity
BLA_RS02095	COG0328	RNA-DNA hybrid ribonuclease activity
BLA_RS02110	COG1597	lipid kinase activity
BLA_RS02110	COG1803	Methylglyoxal synthase
BLA_RS02135	COG2197	response regulator
BLA_RS02155	COG0626	cystathionine gamma-synthase activity
BLA_RS02165	COG2873	o-acetylhomoserine
BLA_RS02175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BLA_RS02190	COG3579	cysteine-type endopeptidase activity
BLA_RS02195	COG0531	amino acid
BLA_RS02205	COG1113	amino acid transport
BLA_RS02220	COG4716	Myosin-crossreactive antigen
BLA_RS02225	COG1063	alcohol dehydrogenase
BLA_RS02230	COG0604	alcohol dehydrogenase
BLA_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
BLA_RS02230	COG3321	synthase
BLA_RS02240	COG5002	protein histidine kinase activity
BLA_RS02245	COG0704	Plays a role in the regulation of phosphate uptake
BLA_RS02250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BLA_RS02255	COG3942	CHAP domain
BLA_RS02255	COG1705	Flagellar rod assembly protein muramidase FlgJ
BLA_RS02260	COG1388	LysM domain
BLA_RS02260	COG0791	NLP P60 protein
BLA_RS02280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BLA_RS02285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BLA_RS02290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BLA_RS02365	COG3189	MarR family transcriptional regulator
BLA_RS02375	COG3250	beta-galactosidase activity
BLA_RS02380	COG1609	Transcriptional regulator
BLA_RS02420	COG0395	ABC-type sugar transport system, permease component
BLA_RS02450	COG1216	Glycosyl transferase, family 2
BLA_RS02455	COG0628	permease
BLA_RS02490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BLA_RS02505	COG1946	Acyl-CoA thioesterase
BLA_RS02515	COG0242	peptide deformylase activity
BLA_RS02520	COG2873	o-acetylhomoserine
BLA_RS02555	COG3507	Belongs to the glycosyl hydrolase 43 family
BLA_RS02560	COG1609	Transcriptional regulator
BLA_RS02595	COG4166	transmembrane transport
BLA_RS02620	COG2365	Tyrosine phosphatase family
BLA_RS02635	COG1132	(ABC) transporter
BLA_RS02640	COG1132	(ABC) transporter
BLA_RS02685	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BLA_RS02690	COG1518	maintenance of DNA repeat elements
BLA_RS02690	COG1468	defense response to virus
BLA_RS02725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BLA_RS02725	COG1328	CTP reductase activity
BLA_RS02730	COG1570	exodeoxyribonuclease VII activity
BLA_RS02735	COG1722	exodeoxyribonuclease VII activity
BLA_RS02755	COG0436	Aminotransferase
BLA_RS02790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BLA_RS02815	COG0210	DNA helicase
BLA_RS02835	COG0714	Associated with various cellular activities
BLA_RS02875	COG1194	a g-specific adenine glycosylase
BLA_RS02880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BLA_RS02900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BLA_RS02910	COG1349	DNA-binding transcription factor activity
BLA_RS02915	COG1216	Glycosyl transferase, family 2
BLA_RS02920	COG0167	dihydroorotate dehydrogenase activity
BLA_RS02925	COG1902	pentaerythritol trinitrate reductase activity
BLA_RS02940	COG0095	Lipoate-protein ligase
BLA_RS02985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BLA_RS03020	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BLA_RS03030	COG1088	dTDP-glucose 4,6-dehydratase activity
BLA_RS03050	COG1216	Glycosyl transferase, family 2
BLA_RS03050	COG1442	glycosyl transferase family 8
BLA_RS03100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BLA_RS03110	COG2814	Major facilitator Superfamily
BLA_RS03165	COG4988	ABC transporter
BLA_RS03180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BLA_RS03190	COG0489	protein tyrosine kinase activity
BLA_RS03210	COG0083	homoserine kinase activity
BLA_RS03215	COG0460	homoserine dehydrogenase
BLA_RS03220	COG0019	diaminopimelate decarboxylase activity
BLA_RS03235	COG0251	oxidation-reduction process
BLA_RS03240	COG0395	ABC-type sugar transport system, permease component
BLA_RS03245	COG3459	Glycosyltransferase 36 associated
BLA_RS03270	COG0545	Peptidyl-prolyl cis-trans isomerase
BLA_RS03280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BLA_RS03315	COG0356	it plays a direct role in the translocation of protons across the membrane
BLA_RS03325	COG0477	Major facilitator Superfamily
BLA_RS03380	COG0582	viral genome integration into host DNA
BLA_RS03395	COG0679	Auxin Efflux Carrier
BLA_RS03400	COG0028	Belongs to the TPP enzyme family
BLA_RS03425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BLA_RS03435	COG0745	RESPONSE REGULATOR receiver
BLA_RS03445	COG0747	negative chemotaxis
BLA_RS03460	COG1605	Chorismate mutase
BLA_RS03460	COG0287	Prephenate dehydrogenase
BLA_RS03525	COG2217	Heavy metal translocating P-type atpase
BLA_RS03535	COG0179	Fumarylacetoacetate (FAA) hydrolase
BLA_RS03560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BLA_RS03575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BLA_RS03625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BLA_RS03640	COG1609	Transcriptional regulator
BLA_RS03680	COG2814	Major facilitator Superfamily
BLA_RS03690	COG0778	Nitroreductase
BLA_RS03705	COG0366	Alpha amylase catalytic
BLA_RS03710	COG2182	Extracellular solute-binding protein
BLA_RS03725	COG0110	maltose O-acetyltransferase activity
BLA_RS03735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BLA_RS03765	COG0708	Exodeoxyribonuclease III
BLA_RS03780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BLA_RS03785	COG0601	transmembrane transport
BLA_RS03790	COG4166	transmembrane transport
BLA_RS03800	COG1136	(ABC) transporter
BLA_RS03805	COG0577	efflux transmembrane transporter activity
BLA_RS03815	COG0287	Prephenate dehydrogenase
BLA_RS03830	COG1217	gtp-binding protein TYPA
BLA_RS03835	COG0477	Major facilitator Superfamily
BLA_RS03865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BLA_RS03880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BLA_RS03890	COG2017	converts alpha-aldose to the beta-anomer
BLA_RS03915	COG0285	dihydrofolate synthase activity
BLA_RS03935	COG0006	proline dipeptidase activity
BLA_RS03940	COG2816	NAD+ diphosphatase activity
BLA_RS03960	COG0582	viral genome integration into host DNA
BLA_RS04040	COG0601	transmembrane transport
BLA_RS04085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BLA_RS04095	COG0768	penicillin binding
BLA_RS04120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BLA_RS04140	COG1230	cation diffusion facilitator family transporter
BLA_RS04150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BLA_RS04160	COG1643	Atp-dependent helicase
BLA_RS04205	COG0587	DNA-directed DNA polymerase activity
BLA_RS04240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BLA_RS04245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BLA_RS04285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BLA_RS04290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BLA_RS04295	COG1957	nucleoside hydrolase
BLA_RS04350	COG3480	Lon protease (S16) C-terminal proteolytic domain
BLA_RS04375	COG0613	PHP domain protein
BLA_RS04385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BLA_RS04410	COG1126	abc transporter atp-binding protein
BLA_RS04415	COG0765	amino acid transport
BLA_RS04420	COG0765	amino acid transport
BLA_RS04425	COG0436	Aminotransferase
BLA_RS04430	COG2011	ABC-type metal ion transport system permease component
BLA_RS04440	COG1464	Belongs to the NlpA lipoprotein family
BLA_RS04445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BLA_RS04490	COG1368	sulfuric ester hydrolase activity
BLA_RS04500	COG1216	Glycosyl transferase, family 2
BLA_RS04550	COG1216	Glycosyl transferase, family 2
BLA_RS04600	COG0084	hydrolase, TatD family'
BLA_RS04615	COG1132	(ABC) transporter
BLA_RS04620	COG1132	(ABC) transporter
BLA_RS04655	COG0586	Pfam SNARE associated Golgi protein
BLA_RS04675	COG1309	transcriptional regulator
BLA_RS04680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BLA_RS04685	COG0789	Transcriptional regulator
BLA_RS04690	COG0484	heat shock protein binding
BLA_RS04720	COG1523	belongs to the glycosyl hydrolase 13 family
BLA_RS04725	COG3833	ABC-type maltose transport systems, permease component
BLA_RS04730	COG1175	transmembrane transport
BLA_RS04740	COG0366	Alpha amylase catalytic
BLA_RS04765	COG1609	Transcriptional regulator
BLA_RS04770	COG2182	Extracellular solute-binding protein
BLA_RS04775	COG0366	Alpha amylase catalytic
BLA_RS04785	COG0180	Tryptophanyl-tRNA synthetase
BLA_RS04800	COG2197	response regulator
BLA_RS04805	COG4585	Histidine kinase
BLA_RS04810	COG1131	(ABC) transporter
BLA_RS04825	COG3804	dihydrodipicolinate reductase
BLA_RS04830	COG0670	Belongs to the BI1 family
BLA_RS04835	COG2357	RelA SpoT domain protein
BLA_RS04855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BLA_RS04865	COG1396	sequence-specific DNA binding
BLA_RS04885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BLA_RS04895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLA_RS04915	COG0142	geranyltranstransferase activity
BLA_RS04925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BLA_RS04930	COG0187	DNA topoisomerase II activity
BLA_RS04955	COG1201	RNA secondary structure unwinding
BLA_RS04965	COG4975	Glucose uptake
BLA_RS04970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BLA_RS04995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLA_RS05005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BLA_RS05010	COG1464	Belongs to the NlpA lipoprotein family
BLA_RS05020	COG2011	ABC-type metal ion transport system permease component
BLA_RS05025	COG1473	amidohydrolase
BLA_RS05040	COG1882	Formate acetyltransferase
BLA_RS05045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BLA_RS05110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BLA_RS05140	COG2873	o-acetylhomoserine
BLA_RS05145	COG1122	ATPase activity
BLA_RS05155	COG0577	efflux transmembrane transporter activity
BLA_RS05155	COG1136	(ABC) transporter
BLA_RS05165	COG2197	response regulator
BLA_RS05170	COG4585	Histidine kinase
BLA_RS05180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BLA_RS05185	COG0012	GTP binding
BLA_RS05205	COG2233	PERMEase
BLA_RS05235	COG1114	Component of the transport system for branched-chain amino acids
BLA_RS05240	COG3340	Belongs to the peptidase S51 family
BLA_RS05245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BLA_RS05250	COG0363	glucosamine-6-phosphate deaminase activity
BLA_RS05270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BLA_RS05270	COG1918	ferrous iron import across plasma membrane
BLA_RS05305	COG1132	(ABC) transporter
BLA_RS05310	COG1132	(ABC) transporter
BLA_RS05315	COG1966	Carbon starvation protein
BLA_RS05325	COG1472	Belongs to the glycosyl hydrolase 3 family
BLA_RS05350	COG1116	anion transmembrane transporter activity
BLA_RS05395	COG1760	l-serine dehydratase
BLA_RS05405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BLA_RS05435	COG1316	TRANSCRIPTIONal
BLA_RS05455	COG3507	Belongs to the glycosyl hydrolase 43 family
BLA_RS05465	COG2272	Belongs to the type-B carboxylesterase lipase family
BLA_RS05475	COG1070	Carbohydrate kinase
BLA_RS05480	COG1940	carbohydrate kinase activity
BLA_RS05500	COG0009	L-threonylcarbamoyladenylate synthase
BLA_RS05520	COG0561	phosphatase activity
BLA_RS05525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BLA_RS05550	COG3590	peptidase
BLA_RS05560	COG0024	Methionine aminopeptidase
BLA_RS05565	COG0372	Belongs to the citrate synthase family
BLA_RS05580	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BLA_RS05585	COG2884	Cell division ATP-binding protein ftsE
BLA_RS05595	COG3942	CHAP domain
BLA_RS05595	COG1388	LysM domain
BLA_RS05615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLA_RS05620	COG0765	amino acid transport
BLA_RS05635	COG2198	Histidine kinase
BLA_RS05635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLA_RS05635	COG0784	Response regulator, receiver
BLA_RS05635	COG2205	protein histidine kinase activity
BLA_RS05640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BLA_RS05660	COG0747	negative chemotaxis
BLA_RS05665	COG0601	transmembrane transport
BLA_RS05670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BLA_RS05680	COG4172	Belongs to the ABC transporter superfamily
BLA_RS05695	COG0514	ATP-dependent DNA helicase (RecQ)
BLA_RS05775	COG0371	Dehydrogenase
BLA_RS05790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BLA_RS05795	COG0358	DNA primase activity
BLA_RS05800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BLA_RS05810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BLA_RS05815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BLA_RS05820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BLA_RS05825	COG0735	belongs to the Fur family
BLA_RS05830	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BLA_RS05840	COG0151	Belongs to the GarS family
BLA_RS05855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BLA_RS05910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BLA_RS05990	COG0284	orotidine-5'-phosphate decarboxylase activity
BLA_RS06015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BLA_RS06030	COG0560	Phosphoserine phosphatase
BLA_RS06035	COG0586	Pfam SNARE associated Golgi protein
BLA_RS06045	COG4122	O-methyltransferase activity
BLA_RS06075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BLA_RS06115	COG0714	Associated with various cellular activities
BLA_RS06130	COG1278	Cold shock
BLA_RS06150	COG0745	RESPONSE REGULATOR receiver
BLA_RS06155	COG2205	protein histidine kinase activity
BLA_RS06160	COG1278	Cold shock
BLA_RS06185	COG0542	response to heat
BLA_RS06200	COG1196	nuclear chromosome segregation
BLA_RS06210	COG1126	abc transporter atp-binding protein
BLA_RS06215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLA_RS06220	COG0765	amino acid transport
BLA_RS06225	COG0765	amino acid transport
BLA_RS06230	COG2326	polyphosphate kinase activity
BLA_RS06245	COG2814	Major facilitator Superfamily
BLA_RS06250	COG1022	Amp-dependent synthetase and ligase
BLA_RS06255	COG3328	transposase activity
BLA_RS06280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BLA_RS06290	COG0656	L-ascorbic acid biosynthetic process
BLA_RS06315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BLA_RS06335	COG2151	metal-sulfur cluster biosynthetic enzyme
BLA_RS06335	COG0489	protein tyrosine kinase activity
BLA_RS06340	COG4721	ABC-type cobalt transport system, permease component
BLA_RS06365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BLA_RS06390	COG1136	(ABC) transporter
BLA_RS06395	COG4721	ABC-type cobalt transport system, permease component
BLA_RS06400	COG4172	Belongs to the ABC transporter superfamily
BLA_RS06405	COG1136	(ABC) transporter
BLA_RS06410	COG0577	efflux transmembrane transporter activity
BLA_RS06420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BLA_RS06510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BLA_RS06515	COG0569	domain protein
BLA_RS06530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BLA_RS06550	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BLA_RS06570	COG0799	negative regulation of ribosome biogenesis
BLA_RS06600	COG0406	alpha-ribazole phosphatase activity
BLA_RS06605	COG0598	Magnesium transport protein CorA
BLA_RS06635	COG0802	atpase or kinase
BLA_RS06690	COG0516	GMP reductase activity
BLA_RS06700	COG1022	Amp-dependent synthetase and ligase
BLA_RS06730	COG0575	Belongs to the CDS family
BLA_RS06770	COG1573	uracil-dna glycosylase
BLA_RS06780	COG0133	tryptophan synthase activity
BLA_RS06795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BLA_RS06810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BLA_RS06830	COG1716	ATPase activity
BLA_RS06845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BLA_RS06850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BLA_RS06900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BLA_RS06920	COG0045	succinate-CoA ligase (ADP-forming) activity
BLA_RS06955	COG0438	transferase activity, transferring glycosyl groups
BLA_RS06960	COG1560	Kdo2-lipid A biosynthetic process
BLA_RS06975	COG0488	(ABC) transporter
BLA_RS06985	COG0456	acetyltransferase
BLA_RS07055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BLA_RS07065	COG0436	Aminotransferase
BLA_RS07075	COG0436	Aminotransferase
BLA_RS07080	COG0561	phosphatase activity
BLA_RS07085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BLA_RS07110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BLA_RS07145	COG0488	(ABC) transporter
BLA_RS07170	COG0450	alkyl hydroperoxide reductase
BLA_RS07180	COG0583	DNA-binding transcription factor activity
BLA_RS07220	COG0167	dihydroorotate dehydrogenase activity
BLA_RS07230	COG0284	orotidine-5'-phosphate decarboxylase activity
BLA_RS07235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BLA_RS07280	COG1119	ATPase activity
BLA_RS07285	COG0297	glycogen (starch) synthase activity
BLA_RS07305	COG0067	glutamate synthase
BLA_RS07305	COG0069	glutamate synthase activity
BLA_RS07305	COG0070	glutamate synthase
BLA_RS07325	COG2860	membrane
BLA_RS07330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BLA_RS07355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BLA_RS07380	COG1702	phosphate starvation-inducible protein PhoH
BLA_RS07385	COG0537	adenosine 5'-monophosphoramidase activity
BLA_RS07390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BLA_RS07415	COG2151	metal-sulfur cluster biosynthetic enzyme
BLA_RS07420	COG0822	iron-sulfur transferase activity
BLA_RS07430	COG0396	ATPase activity
BLA_RS07435	COG0719	Fe-S assembly protein
BLA_RS07445	COG1376	ErfK ybiS ycfS ynhG family protein
BLA_RS07460	COG1523	belongs to the glycosyl hydrolase 13 family
BLA_RS07505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BLA_RS07555	COG0588	phosphoglycerate mutase activity
BLA_RS07560	COG1950	PFAM Membrane protein of
BLA_RS07595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BLA_RS07610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BLA_RS07625	COG1131	(ABC) transporter
BLA_RS07630	COG1725	Transcriptional regulator
BLA_RS07640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BLA_RS07665	COG0563	adenylate kinase activity
BLA_RS07685	COG3039	Transposase
BLA_RS07705	COG0280	phosphate acetyltransferase
BLA_RS07705	COG0857	belongs to the CobB CobQ family
BLA_RS07710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BLA_RS07740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BLA_RS07755	COG0494	nUDIX hydrolase
BLA_RS07780	COG0237	dephospho-CoA kinase activity
BLA_RS07785	COG0539	negative regulation of cytoplasmic translation
BLA_RS07795	COG0803	Belongs to the bacterial solute-binding protein 9 family
BLA_RS07800	COG1121	(ABC) transporter
BLA_RS07815	COG1329	Transcriptional regulator
BLA_RS07825	COG0745	RESPONSE REGULATOR receiver
BLA_RS07830	COG2205	protein histidine kinase activity
BLA_RS07870	COG1609	Transcriptional regulator
BLA_RS07875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BLA_RS07880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BLA_RS07885	COG0366	Alpha amylase catalytic
BLA_RS07900	COG0395	ABC-type sugar transport system, permease component
BLA_RS07905	COG1175	transmembrane transport
BLA_RS07925	COG0037	tRNA processing
BLA_RS07925	COG0590	tRNA wobble adenosine to inosine editing
BLA_RS07930	COG0025	NhaP-type Na H and K H
BLA_RS07950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BLA_RS07955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BLA_RS07965	COG3842	ATPase activity
BLA_RS07970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BLA_RS07990	COG3583	domain protein
BLA_RS08010	COG0617	tRNA 3'-terminal CCA addition
BLA_RS08035	COG0492	ferredoxin-NADP+ reductase activity
BLA_RS08040	COG1475	DNA binding
BLA_RS08045	COG1192	Involved in chromosome partitioning
BLA_RS08055	COG1847	R3H domain protein