locus-tag	class	description
W7Y_RS00010	COG0592	DNA-directed DNA polymerase activity
W7Y_RS00025	COG0187	DNA topoisomerase II activity
W7Y_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
W7Y_RS00045	COG1272	protein, Hemolysin III
W7Y_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
W7Y_RS00055	COG2814	Major facilitator Superfamily
W7Y_RS00070	COG1970	mechanosensitive ion channel activity
W7Y_RS00110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
W7Y_RS00115	COG2226	methyltransferase
W7Y_RS00220	COG0583	DNA-binding transcription factor activity
W7Y_RS00235	COG3231	kanamycin kinase activity
W7Y_RS00275	COG0783	Belongs to the Dps family
W7Y_RS00280	COG1253	flavin adenine dinucleotide binding
W7Y_RS00285	COG0288	reversible hydration of carbon dioxide
W7Y_RS00290	COG1609	Transcriptional regulator
W7Y_RS00315	COG1609	Transcriptional regulator
W7Y_RS00320	COG3534	alpha-L-arabinofuranosidase
W7Y_RS00340	COG0656	L-ascorbic acid biosynthetic process
W7Y_RS00345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
W7Y_RS00360	COG0180	Tryptophanyl-tRNA synthetase
W7Y_RS00375	COG0058	SHG alpha-glucan phosphorylase activity
W7Y_RS00405	COG3764	Sortase (surface protein transpeptidase)
W7Y_RS00420	COG0515	serine threonine protein kinase
W7Y_RS00425	COG0768	penicillin binding
W7Y_RS00455	COG0697	spore germination
W7Y_RS00470	COG2226	methyltransferase
W7Y_RS00475	COG2261	transglycosylase associated protein
W7Y_RS00480	COG2261	transglycosylase associated protein
W7Y_RS00495	COG2217	Heavy metal translocating P-type atpase
W7Y_RS00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
W7Y_RS00515	COG0343	queuine tRNA-ribosyltransferase activity
W7Y_RS00540	COG2814	Major facilitator Superfamily
W7Y_RS00555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
W7Y_RS00585	COG0667	Aldo Keto reductase
W7Y_RS00620	COG1063	alcohol dehydrogenase
W7Y_RS00625	COG0583	DNA-binding transcription factor activity
W7Y_RS00635	COG0191	fructose-bisphosphate aldolase activity
W7Y_RS00645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
W7Y_RS00695	COG2211	Major facilitator Superfamily
W7Y_RS00705	COG4770	biotin carboxylase activity
W7Y_RS00735	COG0477	Major facilitator Superfamily
W7Y_RS00785	COG1132	(ABC) transporter
W7Y_RS00790	COG0390	transport system, permease component
W7Y_RS00795	COG1113	amino acid transport
W7Y_RS00800	COG0577	efflux transmembrane transporter activity
W7Y_RS00800	COG1136	(ABC) transporter
W7Y_RS00810	COG1113	amino acid transport
W7Y_RS00825	COG0577	efflux transmembrane transporter activity
W7Y_RS00830	COG0577	efflux transmembrane transporter activity
W7Y_RS00830	COG1136	(ABC) transporter
W7Y_RS00835	COG1846	Transcriptional regulator
W7Y_RS00855	COG0671	phosphoesterase, PA-phosphatase related
W7Y_RS00860	COG0110	maltose O-acetyltransferase activity
W7Y_RS00900	COG1129	ABC transporter
W7Y_RS00935	COG1309	transcriptional regulator
W7Y_RS00955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
W7Y_RS00965	COG0305	Participates in initiation and elongation during chromosome replication
W7Y_RS00970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
W7Y_RS01005	COG0406	alpha-ribazole phosphatase activity
W7Y_RS01005	COG0494	nUDIX hydrolase
W7Y_RS01090	COG1260	myo-inositol-1-phosphate synthase
W7Y_RS01100	COG1754	DNA topoisomerase type I activity
W7Y_RS01100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
W7Y_RS01160	COG0406	alpha-ribazole phosphatase activity
W7Y_RS01215	COG0446	pyridine nucleotide-disulphide oxidoreductase
W7Y_RS01220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
W7Y_RS01275	COG0436	Aminotransferase
W7Y_RS01290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
W7Y_RS01290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
W7Y_RS01300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
W7Y_RS01315	COG0742	ribosomal rna small subunit methyltransferase
W7Y_RS01330	COG1837	Belongs to the UPF0109 family
W7Y_RS01365	COG0488	(ABC) transporter
W7Y_RS01375	COG0440	acetolactate synthase activity
W7Y_RS01415	COG0667	Aldo Keto reductase
W7Y_RS01480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
W7Y_RS01500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
W7Y_RS01505	COG1530	ribonuclease E activity
W7Y_RS01530	COG0436	Aminotransferase
W7Y_RS01565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
W7Y_RS01565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
W7Y_RS01570	COG1268	BioY protein
W7Y_RS01575	COG4770	biotin carboxylase activity
W7Y_RS01580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
W7Y_RS01605	COG0039	L-malate dehydrogenase activity
W7Y_RS01620	COG1704	LemA family
W7Y_RS01630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
W7Y_RS01635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
W7Y_RS01655	COG0826	peptidase U32
W7Y_RS01670	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
W7Y_RS01680	COG3579	cysteine-type endopeptidase activity
W7Y_RS01685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
W7Y_RS01690	COG2755	lipolytic protein G-D-S-L family
W7Y_RS01690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
W7Y_RS01695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
W7Y_RS01700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
W7Y_RS01710	COG0745	RESPONSE REGULATOR receiver
W7Y_RS01725	COG0581	inorganic phosphate transmembrane transporter activity
W7Y_RS01735	COG2252	PERMEase
W7Y_RS01820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
W7Y_RS01825	COG0531	amino acid
W7Y_RS01840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
W7Y_RS01850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
W7Y_RS01855	COG1739	Uncharacterized protein family UPF0029
W7Y_RS01890	COG1454	alcohol dehydrogenase
W7Y_RS01890	COG1012	belongs to the aldehyde dehydrogenase family
W7Y_RS01950	COG0255	Belongs to the universal ribosomal protein uL29 family
W7Y_RS02080	COG0196	riboflavin kinase activity
W7Y_RS02100	COG0328	RNA-DNA hybrid ribonuclease activity
W7Y_RS02115	COG1597	lipid kinase activity
W7Y_RS02115	COG1803	Methylglyoxal synthase
W7Y_RS02140	COG2197	response regulator
W7Y_RS02160	COG0626	cystathionine gamma-synthase activity
W7Y_RS02170	COG2873	o-acetylhomoserine
W7Y_RS02180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
W7Y_RS02195	COG3579	cysteine-type endopeptidase activity
W7Y_RS02200	COG0531	amino acid
W7Y_RS02210	COG1113	amino acid transport
W7Y_RS02225	COG4716	Myosin-crossreactive antigen
W7Y_RS02230	COG1063	alcohol dehydrogenase
W7Y_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
W7Y_RS02235	COG3321	synthase
W7Y_RS02235	COG0604	alcohol dehydrogenase
W7Y_RS02245	COG5002	protein histidine kinase activity
W7Y_RS02250	COG0704	Plays a role in the regulation of phosphate uptake
W7Y_RS02255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
W7Y_RS02260	COG1705	Flagellar rod assembly protein muramidase FlgJ
W7Y_RS02260	COG3942	CHAP domain
W7Y_RS02265	COG0791	NLP P60 protein
W7Y_RS02265	COG1388	LysM domain
W7Y_RS02285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
W7Y_RS02290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
W7Y_RS02295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
W7Y_RS02370	COG3189	MarR family transcriptional regulator
W7Y_RS02380	COG3250	beta-galactosidase activity
W7Y_RS02385	COG1609	Transcriptional regulator
W7Y_RS02420	COG0395	ABC-type sugar transport system, permease component
W7Y_RS02450	COG1216	Glycosyl transferase, family 2
W7Y_RS02455	COG0628	permease
W7Y_RS02490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
W7Y_RS02505	COG1946	Acyl-CoA thioesterase
W7Y_RS02515	COG0242	peptide deformylase activity
W7Y_RS02520	COG2873	o-acetylhomoserine
W7Y_RS02555	COG3507	Belongs to the glycosyl hydrolase 43 family
W7Y_RS02570	COG1175	transmembrane transport
W7Y_RS02580	COG3507	Belongs to the glycosyl hydrolase 43 family
W7Y_RS02590	COG2272	Belongs to the type-B carboxylesterase lipase family
W7Y_RS02600	COG1070	Carbohydrate kinase
W7Y_RS02605	COG1940	carbohydrate kinase activity
W7Y_RS02625	COG0009	L-threonylcarbamoyladenylate synthase
W7Y_RS02645	COG0561	phosphatase activity
W7Y_RS02650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
W7Y_RS02670	COG3590	peptidase
W7Y_RS02680	COG0024	Methionine aminopeptidase
W7Y_RS02685	COG0372	Belongs to the citrate synthase family
W7Y_RS02700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
W7Y_RS02705	COG2884	Cell division ATP-binding protein ftsE
W7Y_RS02715	COG1388	LysM domain
W7Y_RS02715	COG3942	CHAP domain
W7Y_RS02735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
W7Y_RS02740	COG0765	amino acid transport
W7Y_RS02755	COG0784	Response regulator, receiver
W7Y_RS02755	COG2205	protein histidine kinase activity
W7Y_RS02755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
W7Y_RS02755	COG2198	Histidine kinase
W7Y_RS02760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
W7Y_RS02780	COG0747	negative chemotaxis
W7Y_RS02785	COG0601	transmembrane transport
W7Y_RS02790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
W7Y_RS02800	COG4172	Belongs to the ABC transporter superfamily
W7Y_RS02815	COG0514	ATP-dependent DNA helicase (RecQ)
W7Y_RS02895	COG0371	Dehydrogenase
W7Y_RS02910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
W7Y_RS02915	COG0358	DNA primase activity
W7Y_RS02920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
W7Y_RS02930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
W7Y_RS02935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
W7Y_RS02940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
W7Y_RS02945	COG0735	belongs to the Fur family
W7Y_RS02950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
W7Y_RS02955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
W7Y_RS02960	COG0151	Belongs to the GarS family
W7Y_RS02975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
W7Y_RS03030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
W7Y_RS03110	COG0284	orotidine-5'-phosphate decarboxylase activity
W7Y_RS03135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W7Y_RS03150	COG0560	Phosphoserine phosphatase
W7Y_RS03155	COG0586	Pfam SNARE associated Golgi protein
W7Y_RS03165	COG4122	O-methyltransferase activity
W7Y_RS03195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
W7Y_RS03235	COG0714	Associated with various cellular activities
W7Y_RS03250	COG1278	Cold shock
W7Y_RS03270	COG0745	RESPONSE REGULATOR receiver
W7Y_RS03275	COG2205	protein histidine kinase activity
W7Y_RS03280	COG1278	Cold shock
W7Y_RS03315	COG1196	nuclear chromosome segregation
W7Y_RS03325	COG1126	abc transporter atp-binding protein
W7Y_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
W7Y_RS03335	COG0765	amino acid transport
W7Y_RS03340	COG0765	amino acid transport
W7Y_RS03345	COG2326	polyphosphate kinase activity
W7Y_RS03360	COG2814	Major facilitator Superfamily
W7Y_RS03365	COG1022	Amp-dependent synthetase and ligase
W7Y_RS03370	COG3328	transposase activity
W7Y_RS03395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
W7Y_RS03405	COG0656	L-ascorbic acid biosynthetic process
W7Y_RS03430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
W7Y_RS03450	COG0489	protein tyrosine kinase activity
W7Y_RS03450	COG2151	metal-sulfur cluster biosynthetic enzyme
W7Y_RS03455	COG4721	ABC-type cobalt transport system, permease component
W7Y_RS03480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
W7Y_RS03505	COG1136	(ABC) transporter
W7Y_RS03510	COG4721	ABC-type cobalt transport system, permease component
W7Y_RS03515	COG4172	Belongs to the ABC transporter superfamily
W7Y_RS03520	COG1136	(ABC) transporter
W7Y_RS03525	COG0577	efflux transmembrane transporter activity
W7Y_RS03535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
W7Y_RS03625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
W7Y_RS03630	COG0569	domain protein
W7Y_RS03645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
W7Y_RS03665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
W7Y_RS03685	COG0799	negative regulation of ribosome biogenesis
W7Y_RS03715	COG0406	alpha-ribazole phosphatase activity
W7Y_RS03720	COG0598	Magnesium transport protein CorA
W7Y_RS03750	COG0802	atpase or kinase
W7Y_RS03805	COG0516	GMP reductase activity
W7Y_RS03815	COG1022	Amp-dependent synthetase and ligase
W7Y_RS03845	COG0575	Belongs to the CDS family
W7Y_RS03885	COG1573	uracil-dna glycosylase
W7Y_RS03895	COG0133	tryptophan synthase activity
W7Y_RS03910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
W7Y_RS03925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
W7Y_RS03945	COG1716	ATPase activity
W7Y_RS03960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
W7Y_RS03965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
W7Y_RS04015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
W7Y_RS04035	COG0045	succinate-CoA ligase (ADP-forming) activity
W7Y_RS04070	COG0438	transferase activity, transferring glycosyl groups
W7Y_RS04075	COG1560	Kdo2-lipid A biosynthetic process
W7Y_RS04090	COG0488	(ABC) transporter
W7Y_RS04100	COG0456	acetyltransferase
W7Y_RS04170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
W7Y_RS04180	COG0436	Aminotransferase
W7Y_RS04190	COG0436	Aminotransferase
W7Y_RS04195	COG0561	phosphatase activity
W7Y_RS04200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
W7Y_RS04225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
W7Y_RS04260	COG0488	(ABC) transporter
W7Y_RS04285	COG0450	alkyl hydroperoxide reductase
W7Y_RS04295	COG0583	DNA-binding transcription factor activity
W7Y_RS04335	COG0167	dihydroorotate dehydrogenase activity
W7Y_RS04345	COG0284	orotidine-5'-phosphate decarboxylase activity
W7Y_RS04350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
W7Y_RS04375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
W7Y_RS04395	COG1119	ATPase activity
W7Y_RS04400	COG0297	glycogen (starch) synthase activity
W7Y_RS04420	COG0067	glutamate synthase
W7Y_RS04420	COG0070	glutamate synthase
W7Y_RS04420	COG0069	glutamate synthase activity
W7Y_RS04440	COG2860	membrane
W7Y_RS04445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
W7Y_RS04470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
W7Y_RS04495	COG1702	phosphate starvation-inducible protein PhoH
W7Y_RS04500	COG0537	adenosine 5'-monophosphoramidase activity
W7Y_RS04505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
W7Y_RS04530	COG2151	metal-sulfur cluster biosynthetic enzyme
W7Y_RS04535	COG0822	iron-sulfur transferase activity
W7Y_RS04545	COG0396	ATPase activity
W7Y_RS04550	COG0719	Fe-S assembly protein
W7Y_RS04560	COG1376	ErfK ybiS ycfS ynhG family protein
W7Y_RS04575	COG1523	belongs to the glycosyl hydrolase 13 family
W7Y_RS04620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
W7Y_RS04665	COG0588	phosphoglycerate mutase activity
W7Y_RS04670	COG1950	PFAM Membrane protein of
W7Y_RS04705	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
W7Y_RS04720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
W7Y_RS04735	COG1131	(ABC) transporter
W7Y_RS04740	COG1725	Transcriptional regulator
W7Y_RS04750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
W7Y_RS04775	COG0563	adenylate kinase activity
W7Y_RS04795	COG3039	Transposase
W7Y_RS04815	COG0280	phosphate acetyltransferase
W7Y_RS04815	COG0857	belongs to the CobB CobQ family
W7Y_RS04820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
W7Y_RS04850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
W7Y_RS04865	COG0494	nUDIX hydrolase
W7Y_RS04875	COG0469	pyruvate kinase activity
W7Y_RS04890	COG0237	dephospho-CoA kinase activity
W7Y_RS04895	COG0539	negative regulation of cytoplasmic translation
W7Y_RS04905	COG0803	Belongs to the bacterial solute-binding protein 9 family
W7Y_RS04910	COG1121	(ABC) transporter
W7Y_RS04925	COG1329	Transcriptional regulator
W7Y_RS04935	COG0745	RESPONSE REGULATOR receiver
W7Y_RS04940	COG2205	protein histidine kinase activity
W7Y_RS04970	COG1316	TRANSCRIPTIONal
W7Y_RS04975	COG1316	TRANSCRIPTIONal
W7Y_RS05000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
W7Y_RS05010	COG1760	l-serine dehydratase
W7Y_RS05055	COG1116	anion transmembrane transporter activity
W7Y_RS05080	COG1472	Belongs to the glycosyl hydrolase 3 family
W7Y_RS05090	COG1966	Carbon starvation protein
W7Y_RS05095	COG1132	(ABC) transporter
W7Y_RS05100	COG1132	(ABC) transporter
W7Y_RS05135	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
W7Y_RS05135	COG1918	ferrous iron import across plasma membrane
W7Y_RS05155	COG0363	glucosamine-6-phosphate deaminase activity
W7Y_RS05160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
W7Y_RS05165	COG3340	Belongs to the peptidase S51 family
W7Y_RS05170	COG1114	Component of the transport system for branched-chain amino acids
W7Y_RS05200	COG2233	PERMEase
W7Y_RS05220	COG0012	GTP binding
W7Y_RS05225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
W7Y_RS05235	COG4585	Histidine kinase
W7Y_RS05240	COG2197	response regulator
W7Y_RS05250	COG0577	efflux transmembrane transporter activity
W7Y_RS05250	COG1136	(ABC) transporter
W7Y_RS05260	COG1122	ATPase activity
W7Y_RS05265	COG2873	o-acetylhomoserine
W7Y_RS05295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
W7Y_RS05360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
W7Y_RS05365	COG1882	Formate acetyltransferase
W7Y_RS05380	COG1473	amidohydrolase
W7Y_RS05385	COG2011	ABC-type metal ion transport system permease component
W7Y_RS05395	COG1464	Belongs to the NlpA lipoprotein family
W7Y_RS05400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
W7Y_RS05405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
W7Y_RS05430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
W7Y_RS05435	COG4975	Glucose uptake
W7Y_RS05440	COG1201	RNA secondary structure unwinding
W7Y_RS05465	COG0187	DNA topoisomerase II activity
W7Y_RS05470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
W7Y_RS05480	COG0142	geranyltranstransferase activity
W7Y_RS05500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
W7Y_RS05510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
W7Y_RS05530	COG1396	sequence-specific DNA binding
W7Y_RS05540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
W7Y_RS05560	COG2357	RelA SpoT domain protein
W7Y_RS05565	COG0670	Belongs to the BI1 family
W7Y_RS05570	COG3804	dihydrodipicolinate reductase
W7Y_RS05585	COG1131	(ABC) transporter
W7Y_RS05590	COG4585	Histidine kinase
W7Y_RS05595	COG2197	response regulator
W7Y_RS05615	COG0110	maltose O-acetyltransferase activity
W7Y_RS05625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
W7Y_RS05655	COG0708	Exodeoxyribonuclease III
W7Y_RS05670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
W7Y_RS05675	COG0601	transmembrane transport
W7Y_RS05680	COG4166	transmembrane transport
W7Y_RS05690	COG1136	(ABC) transporter
W7Y_RS05695	COG0577	efflux transmembrane transporter activity
W7Y_RS05705	COG0287	Prephenate dehydrogenase
W7Y_RS05720	COG1217	gtp-binding protein TYPA
W7Y_RS05725	COG0477	Major facilitator Superfamily
W7Y_RS05755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
W7Y_RS05770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
W7Y_RS05780	COG2017	converts alpha-aldose to the beta-anomer
W7Y_RS05805	COG0285	dihydrofolate synthase activity
W7Y_RS05825	COG0006	proline dipeptidase activity
W7Y_RS05830	COG2816	NAD+ diphosphatase activity
W7Y_RS05850	COG0582	viral genome integration into host DNA
W7Y_RS05930	COG0601	transmembrane transport
W7Y_RS05975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
W7Y_RS05985	COG0768	penicillin binding
W7Y_RS06010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
W7Y_RS06030	COG1230	cation diffusion facilitator family transporter
W7Y_RS06040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
W7Y_RS06050	COG1643	Atp-dependent helicase
W7Y_RS06095	COG0587	DNA-directed DNA polymerase activity
W7Y_RS06130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
W7Y_RS06135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
W7Y_RS06175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
W7Y_RS06180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
W7Y_RS06185	COG1957	nucleoside hydrolase
W7Y_RS06240	COG3480	Lon protease (S16) C-terminal proteolytic domain
W7Y_RS06265	COG0613	PHP domain protein
W7Y_RS06275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
W7Y_RS06300	COG1126	abc transporter atp-binding protein
W7Y_RS06305	COG0765	amino acid transport
W7Y_RS06310	COG0765	amino acid transport
W7Y_RS06315	COG0436	Aminotransferase
W7Y_RS06320	COG2011	ABC-type metal ion transport system permease component
W7Y_RS06330	COG1464	Belongs to the NlpA lipoprotein family
W7Y_RS06335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
W7Y_RS06395	COG4166	transmembrane transport
W7Y_RS06400	COG2814	Major facilitator Superfamily
W7Y_RS06405	COG1842	Phage shock protein A
W7Y_RS06425	COG2365	Tyrosine phosphatase family
W7Y_RS06440	COG1132	(ABC) transporter
W7Y_RS06445	COG1132	(ABC) transporter
W7Y_RS06490	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
W7Y_RS06495	COG1468	defense response to virus
W7Y_RS06495	COG1518	maintenance of DNA repeat elements
W7Y_RS06530	COG1328	CTP reductase activity
W7Y_RS06530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
W7Y_RS06535	COG1570	exodeoxyribonuclease VII activity
W7Y_RS06540	COG1722	exodeoxyribonuclease VII activity
W7Y_RS06560	COG0436	Aminotransferase
W7Y_RS06595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
W7Y_RS06620	COG0210	DNA helicase
W7Y_RS06640	COG0714	Associated with various cellular activities
W7Y_RS06680	COG1194	a g-specific adenine glycosylase
W7Y_RS06685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
W7Y_RS06705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
W7Y_RS06715	COG1349	DNA-binding transcription factor activity
W7Y_RS06720	COG1216	Glycosyl transferase, family 2
W7Y_RS06725	COG0167	dihydroorotate dehydrogenase activity
W7Y_RS06730	COG1902	pentaerythritol trinitrate reductase activity
W7Y_RS06735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
W7Y_RS06735	COG4499	WXG100 protein secretion system (Wss), protein YukC
W7Y_RS06745	COG0095	Lipoate-protein ligase
W7Y_RS06790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
W7Y_RS06825	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
W7Y_RS06835	COG1088	dTDP-glucose 4,6-dehydratase activity
W7Y_RS06855	COG1442	glycosyl transferase family 8
W7Y_RS06855	COG1216	Glycosyl transferase, family 2
W7Y_RS06905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
W7Y_RS06915	COG2814	Major facilitator Superfamily
W7Y_RS06970	COG4988	ABC transporter
W7Y_RS06985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
W7Y_RS06995	COG0489	protein tyrosine kinase activity
W7Y_RS07015	COG0083	homoserine kinase activity
W7Y_RS07020	COG0460	homoserine dehydrogenase
W7Y_RS07025	COG0019	diaminopimelate decarboxylase activity
W7Y_RS07040	COG0251	oxidation-reduction process
W7Y_RS07045	COG0395	ABC-type sugar transport system, permease component
W7Y_RS07050	COG3459	Glycosyltransferase 36 associated
W7Y_RS07075	COG0545	Peptidyl-prolyl cis-trans isomerase
W7Y_RS07085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
W7Y_RS07120	COG0356	it plays a direct role in the translocation of protons across the membrane
W7Y_RS07130	COG0477	Major facilitator Superfamily
W7Y_RS07185	COG0582	viral genome integration into host DNA
W7Y_RS07200	COG0679	Auxin Efflux Carrier
W7Y_RS07205	COG0028	Belongs to the TPP enzyme family
W7Y_RS07230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
W7Y_RS07240	COG0745	RESPONSE REGULATOR receiver
W7Y_RS07250	COG0747	negative chemotaxis
W7Y_RS07265	COG0287	Prephenate dehydrogenase
W7Y_RS07265	COG1605	Chorismate mutase
W7Y_RS07330	COG2217	Heavy metal translocating P-type atpase
W7Y_RS07340	COG0179	Fumarylacetoacetate (FAA) hydrolase
W7Y_RS07365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
W7Y_RS07380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
W7Y_RS07430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W7Y_RS07445	COG1609	Transcriptional regulator
W7Y_RS07480	COG1368	sulfuric ester hydrolase activity
W7Y_RS07485	COG1368	sulfuric ester hydrolase activity
W7Y_RS07490	COG1216	Glycosyl transferase, family 2
W7Y_RS07540	COG1216	Glycosyl transferase, family 2
W7Y_RS07590	COG0084	hydrolase, TatD family'
W7Y_RS07605	COG1132	(ABC) transporter
W7Y_RS07610	COG1132	(ABC) transporter
W7Y_RS07645	COG0586	Pfam SNARE associated Golgi protein
W7Y_RS07665	COG1309	transcriptional regulator
W7Y_RS07670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
W7Y_RS07675	COG0789	Transcriptional regulator
W7Y_RS07680	COG0484	heat shock protein binding
W7Y_RS07710	COG1523	belongs to the glycosyl hydrolase 13 family
W7Y_RS07715	COG3833	ABC-type maltose transport systems, permease component
W7Y_RS07720	COG1175	transmembrane transport
W7Y_RS07730	COG0366	Alpha amylase catalytic
W7Y_RS07755	COG1609	Transcriptional regulator
W7Y_RS07780	COG0778	Nitroreductase
W7Y_RS07790	COG2814	Major facilitator Superfamily
W7Y_RS07850	COG1609	Transcriptional regulator
W7Y_RS07855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
W7Y_RS07860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
W7Y_RS07865	COG0366	Alpha amylase catalytic
W7Y_RS07880	COG0395	ABC-type sugar transport system, permease component
W7Y_RS07885	COG1175	transmembrane transport
W7Y_RS07905	COG0037	tRNA processing
W7Y_RS07905	COG0590	tRNA wobble adenosine to inosine editing
W7Y_RS07910	COG0025	NhaP-type Na H and K H
W7Y_RS07930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
W7Y_RS07935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
W7Y_RS07945	COG3842	ATPase activity
W7Y_RS07950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
W7Y_RS07970	COG3583	domain protein
W7Y_RS07990	COG0617	tRNA 3'-terminal CCA addition
W7Y_RS08010	COG0492	ferredoxin-NADP+ reductase activity
W7Y_RS08015	COG1475	DNA binding
W7Y_RS08020	COG1192	Involved in chromosome partitioning
W7Y_RS08030	COG1847	R3H domain protein