locus-tag	class	description
BIF_RS00005	COG2182	Extracellular solute-binding protein
BIF_RS00020	COG0110	maltose O-acetyltransferase activity
BIF_RS00030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BIF_RS00060	COG0708	Exodeoxyribonuclease III
BIF_RS00075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIF_RS00080	COG0601	transmembrane transport
BIF_RS00085	COG4166	transmembrane transport
BIF_RS00095	COG1136	(ABC) transporter
BIF_RS00100	COG0577	efflux transmembrane transporter activity
BIF_RS00110	COG0287	Prephenate dehydrogenase
BIF_RS00125	COG1217	gtp-binding protein TYPA
BIF_RS00130	COG0477	Major facilitator Superfamily
BIF_RS00160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIF_RS00175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIF_RS00185	COG2017	converts alpha-aldose to the beta-anomer
BIF_RS00210	COG0285	dihydrofolate synthase activity
BIF_RS00230	COG0006	proline dipeptidase activity
BIF_RS00235	COG2816	NAD+ diphosphatase activity
BIF_RS00255	COG0582	viral genome integration into host DNA
BIF_RS00335	COG0601	transmembrane transport
BIF_RS00380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIF_RS00390	COG0768	penicillin binding
BIF_RS00415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIF_RS00435	COG1230	cation diffusion facilitator family transporter
BIF_RS00445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIF_RS00455	COG1643	Atp-dependent helicase
BIF_RS00500	COG0587	DNA-directed DNA polymerase activity
BIF_RS00535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIF_RS00540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIF_RS00580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIF_RS00585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIF_RS00590	COG1957	nucleoside hydrolase
BIF_RS00645	COG3480	Lon protease (S16) C-terminal proteolytic domain
BIF_RS00670	COG0613	PHP domain protein
BIF_RS00680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BIF_RS00705	COG1126	abc transporter atp-binding protein
BIF_RS00710	COG0765	amino acid transport
BIF_RS00715	COG0765	amino acid transport
BIF_RS00720	COG0436	Aminotransferase
BIF_RS00725	COG2011	ABC-type metal ion transport system permease component
BIF_RS00735	COG1464	Belongs to the NlpA lipoprotein family
BIF_RS00740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIF_RS00800	COG4166	transmembrane transport
BIF_RS00805	COG2814	Major facilitator Superfamily
BIF_RS00810	COG1842	Phage shock protein A
BIF_RS00830	COG2365	Tyrosine phosphatase family
BIF_RS00845	COG1132	(ABC) transporter
BIF_RS00850	COG1132	(ABC) transporter
BIF_RS00895	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BIF_RS00900	COG1468	defense response to virus
BIF_RS00900	COG1518	maintenance of DNA repeat elements
BIF_RS00935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIF_RS00935	COG1328	CTP reductase activity
BIF_RS00940	COG1570	exodeoxyribonuclease VII activity
BIF_RS00945	COG1722	exodeoxyribonuclease VII activity
BIF_RS01000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIF_RS01025	COG0210	DNA helicase
BIF_RS01045	COG0714	Associated with various cellular activities
BIF_RS01085	COG1194	a g-specific adenine glycosylase
BIF_RS01090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BIF_RS01110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIF_RS01120	COG1349	DNA-binding transcription factor activity
BIF_RS01125	COG1216	Glycosyl transferase, family 2
BIF_RS01130	COG0167	dihydroorotate dehydrogenase activity
BIF_RS01135	COG1902	pentaerythritol trinitrate reductase activity
BIF_RS01140	COG4499	WXG100 protein secretion system (Wss), protein YukC
BIF_RS01140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIF_RS01150	COG0095	Lipoate-protein ligase
BIF_RS01195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIF_RS01230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BIF_RS01240	COG1088	dTDP-glucose 4,6-dehydratase activity
BIF_RS01260	COG1216	Glycosyl transferase, family 2
BIF_RS01260	COG1442	glycosyl transferase family 8
BIF_RS01310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BIF_RS01320	COG2814	Major facilitator Superfamily
BIF_RS01375	COG4988	ABC transporter
BIF_RS01390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIF_RS01400	COG0489	protein tyrosine kinase activity
BIF_RS01420	COG0083	homoserine kinase activity
BIF_RS01425	COG0460	homoserine dehydrogenase
BIF_RS01430	COG0019	diaminopimelate decarboxylase activity
BIF_RS01445	COG0251	oxidation-reduction process
BIF_RS01450	COG0395	ABC-type sugar transport system, permease component
BIF_RS01455	COG3459	Glycosyltransferase 36 associated
BIF_RS01480	COG0545	Peptidyl-prolyl cis-trans isomerase
BIF_RS01490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BIF_RS01525	COG0356	it plays a direct role in the translocation of protons across the membrane
BIF_RS01535	COG0477	Major facilitator Superfamily
BIF_RS01590	COG0582	viral genome integration into host DNA
BIF_RS01605	COG0679	Auxin Efflux Carrier
BIF_RS01610	COG0028	Belongs to the TPP enzyme family
BIF_RS01635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BIF_RS01645	COG0745	RESPONSE REGULATOR receiver
BIF_RS01655	COG0747	negative chemotaxis
BIF_RS01670	COG1605	Chorismate mutase
BIF_RS01670	COG0287	Prephenate dehydrogenase
BIF_RS01735	COG2217	Heavy metal translocating P-type atpase
BIF_RS01745	COG0179	Fumarylacetoacetate (FAA) hydrolase
BIF_RS01770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIF_RS01785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIF_RS01835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIF_RS01850	COG1609	Transcriptional regulator
BIF_RS01885	COG1368	sulfuric ester hydrolase activity
BIF_RS01890	COG1368	sulfuric ester hydrolase activity
BIF_RS01895	COG1216	Glycosyl transferase, family 2
BIF_RS01945	COG1216	Glycosyl transferase, family 2
BIF_RS01995	COG0084	hydrolase, TatD family'
BIF_RS02010	COG1132	(ABC) transporter
BIF_RS02015	COG1132	(ABC) transporter
BIF_RS02050	COG0586	Pfam SNARE associated Golgi protein
BIF_RS02070	COG1309	transcriptional regulator
BIF_RS02075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIF_RS02080	COG0789	Transcriptional regulator
BIF_RS02085	COG0484	heat shock protein binding
BIF_RS02115	COG1523	belongs to the glycosyl hydrolase 13 family
BIF_RS02120	COG3833	ABC-type maltose transport systems, permease component
BIF_RS02125	COG1175	transmembrane transport
BIF_RS02135	COG0366	Alpha amylase catalytic
BIF_RS02160	COG1609	Transcriptional regulator
BIF_RS02170	COG0366	Alpha amylase catalytic
BIF_RS02185	COG0778	Nitroreductase
BIF_RS02195	COG2814	Major facilitator Superfamily
BIF_RS02255	COG1609	Transcriptional regulator
BIF_RS02260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BIF_RS02265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BIF_RS02270	COG0366	Alpha amylase catalytic
BIF_RS02285	COG0395	ABC-type sugar transport system, permease component
BIF_RS02290	COG1175	transmembrane transport
BIF_RS02310	COG0590	tRNA wobble adenosine to inosine editing
BIF_RS02310	COG0037	tRNA processing
BIF_RS02315	COG0025	NhaP-type Na H and K H
BIF_RS02335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BIF_RS02340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIF_RS02350	COG3842	ATPase activity
BIF_RS02355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BIF_RS02375	COG3583	domain protein
BIF_RS02395	COG0617	tRNA 3'-terminal CCA addition
BIF_RS02415	COG0492	ferredoxin-NADP+ reductase activity
BIF_RS02420	COG1475	DNA binding
BIF_RS02425	COG1192	Involved in chromosome partitioning
BIF_RS02435	COG1847	R3H domain protein
BIF_RS02460	COG0592	DNA-directed DNA polymerase activity
BIF_RS02475	COG0187	DNA topoisomerase II activity
BIF_RS02480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIF_RS02495	COG1272	protein, Hemolysin III
BIF_RS02500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIF_RS02505	COG2814	Major facilitator Superfamily
BIF_RS02520	COG1970	mechanosensitive ion channel activity
BIF_RS02560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIF_RS02565	COG2226	methyltransferase
BIF_RS02670	COG0583	DNA-binding transcription factor activity
BIF_RS02685	COG3231	kanamycin kinase activity
BIF_RS02725	COG0783	Belongs to the Dps family
BIF_RS02730	COG1253	flavin adenine dinucleotide binding
BIF_RS02735	COG0288	reversible hydration of carbon dioxide
BIF_RS02740	COG1609	Transcriptional regulator
BIF_RS02765	COG1609	Transcriptional regulator
BIF_RS02770	COG3534	alpha-L-arabinofuranosidase
BIF_RS02790	COG0656	L-ascorbic acid biosynthetic process
BIF_RS02795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BIF_RS02810	COG0180	Tryptophanyl-tRNA synthetase
BIF_RS02825	COG0058	SHG alpha-glucan phosphorylase activity
BIF_RS02855	COG3764	Sortase (surface protein transpeptidase)
BIF_RS02870	COG0515	serine threonine protein kinase
BIF_RS02875	COG0768	penicillin binding
BIF_RS02905	COG0697	spore germination
BIF_RS02920	COG2226	methyltransferase
BIF_RS02925	COG2261	transglycosylase associated protein
BIF_RS02930	COG2261	transglycosylase associated protein
BIF_RS02945	COG2217	Heavy metal translocating P-type atpase
BIF_RS02950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIF_RS02965	COG0343	queuine tRNA-ribosyltransferase activity
BIF_RS02990	COG2814	Major facilitator Superfamily
BIF_RS03005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIF_RS03035	COG0667	Aldo Keto reductase
BIF_RS03070	COG1063	alcohol dehydrogenase
BIF_RS03075	COG0583	DNA-binding transcription factor activity
BIF_RS03085	COG0191	fructose-bisphosphate aldolase activity
BIF_RS03095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIF_RS03145	COG2211	Major facilitator Superfamily
BIF_RS03155	COG4770	biotin carboxylase activity
BIF_RS03185	COG0477	Major facilitator Superfamily
BIF_RS03235	COG1132	(ABC) transporter
BIF_RS03240	COG0390	transport system, permease component
BIF_RS03245	COG1113	amino acid transport
BIF_RS03250	COG1136	(ABC) transporter
BIF_RS03250	COG0577	efflux transmembrane transporter activity
BIF_RS03260	COG1113	amino acid transport
BIF_RS03275	COG0577	efflux transmembrane transporter activity
BIF_RS03280	COG0577	efflux transmembrane transporter activity
BIF_RS03280	COG1136	(ABC) transporter
BIF_RS03285	COG1846	Transcriptional regulator
BIF_RS03305	COG0671	phosphoesterase, PA-phosphatase related
BIF_RS03310	COG0110	maltose O-acetyltransferase activity
BIF_RS03350	COG1129	ABC transporter
BIF_RS03385	COG1309	transcriptional regulator
BIF_RS03405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BIF_RS03415	COG0305	Participates in initiation and elongation during chromosome replication
BIF_RS03420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIF_RS03455	COG0494	nUDIX hydrolase
BIF_RS03455	COG0406	alpha-ribazole phosphatase activity
BIF_RS03540	COG1260	myo-inositol-1-phosphate synthase
BIF_RS03550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIF_RS03550	COG1754	DNA topoisomerase type I activity
BIF_RS03610	COG0406	alpha-ribazole phosphatase activity
BIF_RS03665	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIF_RS03670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIF_RS03720	COG0436	Aminotransferase
BIF_RS03735	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BIF_RS03735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BIF_RS03745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIF_RS03760	COG0742	ribosomal rna small subunit methyltransferase
BIF_RS03775	COG1837	Belongs to the UPF0109 family
BIF_RS03810	COG0488	(ABC) transporter
BIF_RS03820	COG0440	acetolactate synthase activity
BIF_RS03860	COG0667	Aldo Keto reductase
BIF_RS03925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIF_RS03945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIF_RS03950	COG1530	ribonuclease E activity
BIF_RS03975	COG0436	Aminotransferase
BIF_RS04010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BIF_RS04010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BIF_RS04015	COG1268	BioY protein
BIF_RS04020	COG4770	biotin carboxylase activity
BIF_RS04025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BIF_RS04050	COG0039	L-malate dehydrogenase activity
BIF_RS04065	COG1704	LemA family
BIF_RS04075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIF_RS04080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIF_RS04100	COG0826	peptidase U32
BIF_RS04115	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BIF_RS04125	COG3579	cysteine-type endopeptidase activity
BIF_RS04130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BIF_RS04135	COG2755	lipolytic protein G-D-S-L family
BIF_RS04135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BIF_RS04140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BIF_RS04145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BIF_RS04155	COG0745	RESPONSE REGULATOR receiver
BIF_RS04170	COG0581	inorganic phosphate transmembrane transporter activity
BIF_RS04180	COG2252	PERMEase
BIF_RS04265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BIF_RS04270	COG0531	amino acid
BIF_RS04285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIF_RS04295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIF_RS04300	COG1739	Uncharacterized protein family UPF0029
BIF_RS04335	COG1454	alcohol dehydrogenase
BIF_RS04335	COG1012	belongs to the aldehyde dehydrogenase family
BIF_RS04395	COG0255	Belongs to the universal ribosomal protein uL29 family
BIF_RS04525	COG0196	riboflavin kinase activity
BIF_RS04545	COG0328	RNA-DNA hybrid ribonuclease activity
BIF_RS04560	COG1803	Methylglyoxal synthase
BIF_RS04560	COG1597	lipid kinase activity
BIF_RS04585	COG2197	response regulator
BIF_RS04605	COG0626	cystathionine gamma-synthase activity
BIF_RS04615	COG2873	o-acetylhomoserine
BIF_RS04625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BIF_RS04640	COG3579	cysteine-type endopeptidase activity
BIF_RS04645	COG0531	amino acid
BIF_RS04655	COG1113	amino acid transport
BIF_RS04670	COG4716	Myosin-crossreactive antigen
BIF_RS04675	COG1063	alcohol dehydrogenase
BIF_RS04680	COG3321	synthase
BIF_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
BIF_RS04680	COG0604	alcohol dehydrogenase
BIF_RS04690	COG5002	protein histidine kinase activity
BIF_RS04695	COG0704	Plays a role in the regulation of phosphate uptake
BIF_RS04700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BIF_RS04705	COG1705	Flagellar rod assembly protein muramidase FlgJ
BIF_RS04705	COG3942	CHAP domain
BIF_RS04710	COG1388	LysM domain
BIF_RS04710	COG0791	NLP P60 protein
BIF_RS04730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIF_RS04735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIF_RS04740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIF_RS04815	COG3189	MarR family transcriptional regulator
BIF_RS04830	COG1609	Transcriptional regulator
BIF_RS04865	COG0395	ABC-type sugar transport system, permease component
BIF_RS04895	COG1216	Glycosyl transferase, family 2
BIF_RS04900	COG0628	permease
BIF_RS04935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIF_RS04950	COG1946	Acyl-CoA thioesterase
BIF_RS04960	COG0242	peptide deformylase activity
BIF_RS04965	COG2873	o-acetylhomoserine
BIF_RS05000	COG3507	Belongs to the glycosyl hydrolase 43 family
BIF_RS05015	COG1175	transmembrane transport
BIF_RS05025	COG3507	Belongs to the glycosyl hydrolase 43 family
BIF_RS05035	COG2272	Belongs to the type-B carboxylesterase lipase family
BIF_RS05045	COG1070	Carbohydrate kinase
BIF_RS05050	COG1940	carbohydrate kinase activity
BIF_RS05070	COG0009	L-threonylcarbamoyladenylate synthase
BIF_RS05090	COG0561	phosphatase activity
BIF_RS05095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIF_RS05115	COG3590	peptidase
BIF_RS05125	COG0024	Methionine aminopeptidase
BIF_RS05130	COG0372	Belongs to the citrate synthase family
BIF_RS05145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIF_RS05150	COG2884	Cell division ATP-binding protein ftsE
BIF_RS05160	COG1388	LysM domain
BIF_RS05160	COG3942	CHAP domain
BIF_RS05180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIF_RS05185	COG0765	amino acid transport
BIF_RS05200	COG0784	Response regulator, receiver
BIF_RS05200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIF_RS05200	COG2198	Histidine kinase
BIF_RS05200	COG2205	protein histidine kinase activity
BIF_RS05205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIF_RS05225	COG0747	negative chemotaxis
BIF_RS05230	COG0601	transmembrane transport
BIF_RS05235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIF_RS05245	COG4172	Belongs to the ABC transporter superfamily
BIF_RS05260	COG0514	ATP-dependent DNA helicase (RecQ)
BIF_RS05345	COG0371	Dehydrogenase
BIF_RS05360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIF_RS05365	COG0358	DNA primase activity
BIF_RS05370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BIF_RS05380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIF_RS05385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BIF_RS05390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIF_RS05395	COG0735	belongs to the Fur family
BIF_RS05400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BIF_RS05405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BIF_RS05410	COG0151	Belongs to the GarS family
BIF_RS05425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIF_RS05480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIF_RS05560	COG0284	orotidine-5'-phosphate decarboxylase activity
BIF_RS05585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BIF_RS05600	COG0560	Phosphoserine phosphatase
BIF_RS05605	COG0586	Pfam SNARE associated Golgi protein
BIF_RS05615	COG4122	O-methyltransferase activity
BIF_RS05645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIF_RS05685	COG0714	Associated with various cellular activities
BIF_RS05700	COG1278	Cold shock
BIF_RS05720	COG0745	RESPONSE REGULATOR receiver
BIF_RS05725	COG2205	protein histidine kinase activity
BIF_RS05730	COG1278	Cold shock
BIF_RS05765	COG1196	nuclear chromosome segregation
BIF_RS05775	COG1126	abc transporter atp-binding protein
BIF_RS05780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIF_RS05785	COG0765	amino acid transport
BIF_RS05790	COG0765	amino acid transport
BIF_RS05795	COG2326	polyphosphate kinase activity
BIF_RS05810	COG2814	Major facilitator Superfamily
BIF_RS05815	COG1022	Amp-dependent synthetase and ligase
BIF_RS05820	COG3328	transposase activity
BIF_RS05845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BIF_RS05855	COG0656	L-ascorbic acid biosynthetic process
BIF_RS05880	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BIF_RS05900	COG0489	protein tyrosine kinase activity
BIF_RS05900	COG2151	metal-sulfur cluster biosynthetic enzyme
BIF_RS05905	COG4721	ABC-type cobalt transport system, permease component
BIF_RS05930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIF_RS05950	COG1136	(ABC) transporter
BIF_RS05955	COG4721	ABC-type cobalt transport system, permease component
BIF_RS05960	COG1122	ATPase activity
BIF_RS05965	COG1136	(ABC) transporter
BIF_RS05970	COG0577	efflux transmembrane transporter activity
BIF_RS05980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIF_RS06070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIF_RS06075	COG0569	domain protein
BIF_RS06090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIF_RS06110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIF_RS06130	COG0799	negative regulation of ribosome biogenesis
BIF_RS06160	COG0406	alpha-ribazole phosphatase activity
BIF_RS06165	COG0598	Magnesium transport protein CorA
BIF_RS06195	COG0802	atpase or kinase
BIF_RS06250	COG0516	GMP reductase activity
BIF_RS06290	COG0575	Belongs to the CDS family
BIF_RS06330	COG1573	uracil-dna glycosylase
BIF_RS06340	COG0133	tryptophan synthase activity
BIF_RS06355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIF_RS06370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIF_RS06390	COG1716	ATPase activity
BIF_RS06405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIF_RS06410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIF_RS06460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIF_RS06480	COG0045	succinate-CoA ligase (ADP-forming) activity
BIF_RS06515	COG0438	transferase activity, transferring glycosyl groups
BIF_RS06520	COG1560	Kdo2-lipid A biosynthetic process
BIF_RS06535	COG0488	(ABC) transporter
BIF_RS06545	COG0456	acetyltransferase
BIF_RS06615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIF_RS06625	COG0436	Aminotransferase
BIF_RS06635	COG0436	Aminotransferase
BIF_RS06640	COG0561	phosphatase activity
BIF_RS06645	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIF_RS06670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIF_RS06705	COG0488	(ABC) transporter
BIF_RS06730	COG0450	alkyl hydroperoxide reductase
BIF_RS06740	COG0583	DNA-binding transcription factor activity
BIF_RS06780	COG0167	dihydroorotate dehydrogenase activity
BIF_RS06790	COG0284	orotidine-5'-phosphate decarboxylase activity
BIF_RS06795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIF_RS06820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BIF_RS06840	COG1119	ATPase activity
BIF_RS06845	COG0297	glycogen (starch) synthase activity
BIF_RS06865	COG0070	glutamate synthase
BIF_RS06865	COG0069	glutamate synthase activity
BIF_RS06865	COG0067	glutamate synthase
BIF_RS06885	COG2860	membrane
BIF_RS06890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIF_RS06915	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BIF_RS06940	COG1702	phosphate starvation-inducible protein PhoH
BIF_RS06945	COG0537	adenosine 5'-monophosphoramidase activity
BIF_RS06950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BIF_RS06980	COG0822	iron-sulfur transferase activity
BIF_RS06990	COG0396	ATPase activity
BIF_RS06995	COG0719	Fe-S assembly protein
BIF_RS07005	COG1376	ErfK ybiS ycfS ynhG family protein
BIF_RS07020	COG1523	belongs to the glycosyl hydrolase 13 family
BIF_RS07110	COG0588	phosphoglycerate mutase activity
BIF_RS07115	COG1950	PFAM Membrane protein of
BIF_RS07150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BIF_RS07165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BIF_RS07180	COG1131	(ABC) transporter
BIF_RS07185	COG1725	Transcriptional regulator
BIF_RS07195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BIF_RS07220	COG0563	adenylate kinase activity
BIF_RS07235	COG3039	Transposase
BIF_RS07255	COG0857	belongs to the CobB CobQ family
BIF_RS07255	COG0280	phosphate acetyltransferase
BIF_RS07260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIF_RS07290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIF_RS07305	COG0494	nUDIX hydrolase
BIF_RS07315	COG0469	pyruvate kinase activity
BIF_RS07330	COG0237	dephospho-CoA kinase activity
BIF_RS07335	COG0539	negative regulation of cytoplasmic translation
BIF_RS07345	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIF_RS07350	COG1121	(ABC) transporter
BIF_RS07365	COG1329	Transcriptional regulator
BIF_RS07375	COG0745	RESPONSE REGULATOR receiver
BIF_RS07380	COG2205	protein histidine kinase activity
BIF_RS07410	COG1316	TRANSCRIPTIONal
BIF_RS07415	COG1316	TRANSCRIPTIONal
BIF_RS07440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIF_RS07450	COG1760	l-serine dehydratase
BIF_RS07495	COG1116	anion transmembrane transporter activity
BIF_RS07520	COG1472	Belongs to the glycosyl hydrolase 3 family
BIF_RS07530	COG1966	Carbon starvation protein
BIF_RS07535	COG1132	(ABC) transporter
BIF_RS07540	COG1132	(ABC) transporter
BIF_RS07575	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BIF_RS07575	COG1918	ferrous iron import across plasma membrane
BIF_RS07595	COG0363	glucosamine-6-phosphate deaminase activity
BIF_RS07600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIF_RS07605	COG3340	Belongs to the peptidase S51 family
BIF_RS07610	COG1114	Component of the transport system for branched-chain amino acids
BIF_RS07640	COG2233	PERMEase
BIF_RS07660	COG0012	GTP binding
BIF_RS07665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIF_RS07675	COG4585	Histidine kinase
BIF_RS07680	COG2197	response regulator
BIF_RS07690	COG0577	efflux transmembrane transporter activity
BIF_RS07690	COG1136	(ABC) transporter
BIF_RS07700	COG1122	ATPase activity
BIF_RS07705	COG2873	o-acetylhomoserine
BIF_RS07735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BIF_RS07800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BIF_RS07805	COG1882	Formate acetyltransferase
BIF_RS07820	COG1473	amidohydrolase
BIF_RS07825	COG2011	ABC-type metal ion transport system permease component
BIF_RS07835	COG1464	Belongs to the NlpA lipoprotein family
BIF_RS07840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIF_RS07845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIF_RS07870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIF_RS07875	COG4975	Glucose uptake
BIF_RS07880	COG1201	RNA secondary structure unwinding
BIF_RS07905	COG0187	DNA topoisomerase II activity
BIF_RS07910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIF_RS07920	COG0142	geranyltranstransferase activity
BIF_RS07940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIF_RS07950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BIF_RS07970	COG1396	sequence-specific DNA binding
BIF_RS07980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIF_RS08000	COG2357	RelA SpoT domain protein
BIF_RS08005	COG0670	Belongs to the BI1 family
BIF_RS08010	COG3804	dihydrodipicolinate reductase
BIF_RS08025	COG1131	(ABC) transporter
BIF_RS08030	COG4585	Histidine kinase
BIF_RS08035	COG2197	response regulator
BIF_RS08050	COG0366	Alpha amylase catalytic