locus-tag	class	description
BIF_RS00010	COG0592	DNA-directed DNA polymerase activity
BIF_RS00025	COG0187	DNA topoisomerase II activity
BIF_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIF_RS00045	COG1272	protein, Hemolysin III
BIF_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIF_RS00055	COG2814	Major facilitator Superfamily
BIF_RS00070	COG1970	mechanosensitive ion channel activity
BIF_RS00110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIF_RS00115	COG2226	methyltransferase
BIF_RS00220	COG0583	DNA-binding transcription factor activity
BIF_RS00235	COG3231	kanamycin kinase activity
BIF_RS00275	COG0783	Belongs to the Dps family
BIF_RS00280	COG1253	flavin adenine dinucleotide binding
BIF_RS00285	COG0288	reversible hydration of carbon dioxide
BIF_RS00290	COG1609	Transcriptional regulator
BIF_RS00310	COG1609	Transcriptional regulator
BIF_RS00315	COG3534	alpha-L-arabinofuranosidase
BIF_RS00335	COG0656	L-ascorbic acid biosynthetic process
BIF_RS00340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BIF_RS00355	COG0180	Tryptophanyl-tRNA synthetase
BIF_RS00370	COG0058	SHG alpha-glucan phosphorylase activity
BIF_RS00400	COG3764	Sortase (surface protein transpeptidase)
BIF_RS00415	COG0515	serine threonine protein kinase
BIF_RS00420	COG0768	penicillin binding
BIF_RS00450	COG0697	spore germination
BIF_RS00465	COG2226	methyltransferase
BIF_RS00470	COG2261	transglycosylase associated protein
BIF_RS00475	COG2261	transglycosylase associated protein
BIF_RS00490	COG2217	Heavy metal translocating P-type atpase
BIF_RS00495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIF_RS00510	COG0343	queuine tRNA-ribosyltransferase activity
BIF_RS00535	COG2814	Major facilitator Superfamily
BIF_RS00550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIF_RS00580	COG0667	Aldo Keto reductase
BIF_RS00615	COG1063	alcohol dehydrogenase
BIF_RS00620	COG0583	DNA-binding transcription factor activity
BIF_RS00630	COG0191	fructose-bisphosphate aldolase activity
BIF_RS00640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIF_RS00685	COG2211	Major facilitator Superfamily
BIF_RS00730	COG0477	Major facilitator Superfamily
BIF_RS00785	COG1132	(ABC) transporter
BIF_RS00790	COG0390	transport system, permease component
BIF_RS00795	COG1113	amino acid transport
BIF_RS00800	COG1136	(ABC) transporter
BIF_RS00800	COG0577	efflux transmembrane transporter activity
BIF_RS00810	COG1113	amino acid transport
BIF_RS00825	COG0577	efflux transmembrane transporter activity
BIF_RS00830	COG1136	(ABC) transporter
BIF_RS00830	COG0577	efflux transmembrane transporter activity
BIF_RS00835	COG1846	Transcriptional regulator
BIF_RS00855	COG0671	phosphoesterase, PA-phosphatase related
BIF_RS00860	COG0110	maltose O-acetyltransferase activity
BIF_RS00900	COG1129	ABC transporter
BIF_RS00935	COG1309	transcriptional regulator
BIF_RS00955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BIF_RS00965	COG0305	Participates in initiation and elongation during chromosome replication
BIF_RS00970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIF_RS01005	COG0494	nUDIX hydrolase
BIF_RS01005	COG0406	alpha-ribazole phosphatase activity
BIF_RS01095	COG1260	myo-inositol-1-phosphate synthase
BIF_RS01110	COG1754	DNA topoisomerase type I activity
BIF_RS01110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIF_RS01170	COG0406	alpha-ribazole phosphatase activity
BIF_RS01225	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIF_RS01230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIF_RS01280	COG0436	Aminotransferase
BIF_RS01295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BIF_RS01295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BIF_RS01305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIF_RS01320	COG0742	ribosomal rna small subunit methyltransferase
BIF_RS01335	COG1837	Belongs to the UPF0109 family
BIF_RS01370	COG0488	(ABC) transporter
BIF_RS01380	COG0440	acetolactate synthase activity
BIF_RS01420	COG0667	Aldo Keto reductase
BIF_RS01485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIF_RS01505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIF_RS01510	COG1530	ribonuclease E activity
BIF_RS01535	COG0436	Aminotransferase
BIF_RS01570	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BIF_RS01570	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BIF_RS01575	COG1268	BioY protein
BIF_RS01580	COG4770	biotin carboxylase activity
BIF_RS01585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BIF_RS01610	COG0039	L-malate dehydrogenase activity
BIF_RS01625	COG1704	LemA family
BIF_RS01635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIF_RS01640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIF_RS01660	COG0826	peptidase U32
BIF_RS01675	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BIF_RS01685	COG3579	cysteine-type endopeptidase activity
BIF_RS01690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BIF_RS01695	COG2755	lipolytic protein G-D-S-L family
BIF_RS01695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BIF_RS01700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BIF_RS01705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BIF_RS01715	COG0745	RESPONSE REGULATOR receiver
BIF_RS01730	COG0581	inorganic phosphate transmembrane transporter activity
BIF_RS01740	COG2252	PERMEase
BIF_RS01825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BIF_RS01830	COG0531	amino acid
BIF_RS01845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIF_RS01855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIF_RS01860	COG1739	Uncharacterized protein family UPF0029
BIF_RS01895	COG1454	alcohol dehydrogenase
BIF_RS01895	COG1012	belongs to the aldehyde dehydrogenase family
BIF_RS01955	COG0255	Belongs to the universal ribosomal protein uL29 family
BIF_RS02090	COG0196	riboflavin kinase activity
BIF_RS02115	COG0328	RNA-DNA hybrid ribonuclease activity
BIF_RS02130	COG1803	Methylglyoxal synthase
BIF_RS02130	COG1597	lipid kinase activity
BIF_RS02155	COG2197	response regulator
BIF_RS02175	COG0626	cystathionine gamma-synthase activity
BIF_RS02185	COG2873	o-acetylhomoserine
BIF_RS02195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BIF_RS02210	COG3579	cysteine-type endopeptidase activity
BIF_RS02215	COG0531	amino acid
BIF_RS02225	COG1113	amino acid transport
BIF_RS02240	COG4716	Myosin-crossreactive antigen
BIF_RS02245	COG1063	alcohol dehydrogenase
BIF_RS02250	COG3321	synthase
BIF_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
BIF_RS02250	COG0604	alcohol dehydrogenase
BIF_RS02265	COG5002	protein histidine kinase activity
BIF_RS02270	COG0704	Plays a role in the regulation of phosphate uptake
BIF_RS02275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BIF_RS02280	COG3942	CHAP domain
BIF_RS02280	COG1705	Flagellar rod assembly protein muramidase FlgJ
BIF_RS02285	COG1388	LysM domain
BIF_RS02285	COG0791	NLP P60 protein
BIF_RS02305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIF_RS02310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIF_RS02315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIF_RS02385	COG3189	MarR family transcriptional regulator
BIF_RS02395	COG3250	beta-galactosidase activity
BIF_RS02400	COG1609	Transcriptional regulator
BIF_RS02435	COG0395	ABC-type sugar transport system, permease component
BIF_RS02465	COG1216	Glycosyl transferase, family 2
BIF_RS02470	COG0628	permease
BIF_RS02505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIF_RS02520	COG1946	Acyl-CoA thioesterase
BIF_RS02530	COG0242	peptide deformylase activity
BIF_RS02535	COG2873	o-acetylhomoserine
BIF_RS02570	COG3507	Belongs to the glycosyl hydrolase 43 family
BIF_RS02585	COG1175	transmembrane transport
BIF_RS02595	COG3507	Belongs to the glycosyl hydrolase 43 family
BIF_RS02605	COG2272	Belongs to the type-B carboxylesterase lipase family
BIF_RS02615	COG1070	Carbohydrate kinase
BIF_RS02620	COG1940	carbohydrate kinase activity
BIF_RS02640	COG0009	L-threonylcarbamoyladenylate synthase
BIF_RS02660	COG0561	phosphatase activity
BIF_RS02665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIF_RS02685	COG3590	peptidase
BIF_RS02695	COG0024	Methionine aminopeptidase
BIF_RS02700	COG0372	Belongs to the citrate synthase family
BIF_RS02715	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIF_RS02720	COG2884	Cell division ATP-binding protein ftsE
BIF_RS02730	COG3942	CHAP domain
BIF_RS02730	COG1388	LysM domain
BIF_RS02745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIF_RS02750	COG0765	amino acid transport
BIF_RS02765	COG0784	Response regulator, receiver
BIF_RS02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIF_RS02765	COG2205	protein histidine kinase activity
BIF_RS02765	COG2198	Histidine kinase
BIF_RS02770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIF_RS02790	COG0747	negative chemotaxis
BIF_RS02795	COG0601	transmembrane transport
BIF_RS02800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIF_RS02810	COG4172	Belongs to the ABC transporter superfamily
BIF_RS02825	COG0514	ATP-dependent DNA helicase (RecQ)
BIF_RS02910	COG0371	Dehydrogenase
BIF_RS02925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIF_RS02930	COG0358	DNA primase activity
BIF_RS02935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BIF_RS02945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIF_RS02950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BIF_RS02955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIF_RS02960	COG0735	belongs to the Fur family
BIF_RS02965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BIF_RS02970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BIF_RS02975	COG0151	Belongs to the GarS family
BIF_RS02990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIF_RS03045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIF_RS03125	COG0284	orotidine-5'-phosphate decarboxylase activity
BIF_RS03150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BIF_RS03165	COG0560	Phosphoserine phosphatase
BIF_RS03170	COG0586	Pfam SNARE associated Golgi protein
BIF_RS03180	COG4122	O-methyltransferase activity
BIF_RS03210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIF_RS03250	COG0714	Associated with various cellular activities
BIF_RS03265	COG1278	Cold shock
BIF_RS03285	COG0745	RESPONSE REGULATOR receiver
BIF_RS03290	COG2205	protein histidine kinase activity
BIF_RS03295	COG1278	Cold shock
BIF_RS03330	COG1196	nuclear chromosome segregation
BIF_RS03340	COG1126	abc transporter atp-binding protein
BIF_RS03345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIF_RS03350	COG0765	amino acid transport
BIF_RS03355	COG0765	amino acid transport
BIF_RS03360	COG2326	polyphosphate kinase activity
BIF_RS03375	COG2814	Major facilitator Superfamily
BIF_RS03380	COG1022	Amp-dependent synthetase and ligase
BIF_RS03385	COG3328	transposase activity
BIF_RS03415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BIF_RS03425	COG0656	L-ascorbic acid biosynthetic process
BIF_RS03450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BIF_RS03470	COG0489	protein tyrosine kinase activity
BIF_RS03470	COG2151	metal-sulfur cluster biosynthetic enzyme
BIF_RS03475	COG4721	ABC-type cobalt transport system, permease component
BIF_RS03500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIF_RS03535	COG4721	ABC-type cobalt transport system, permease component
BIF_RS03540	COG4172	Belongs to the ABC transporter superfamily
BIF_RS03545	COG1136	(ABC) transporter
BIF_RS03550	COG0577	efflux transmembrane transporter activity
BIF_RS03560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIF_RS03650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIF_RS03655	COG0569	domain protein
BIF_RS03670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIF_RS03690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIF_RS03710	COG0799	negative regulation of ribosome biogenesis
BIF_RS03740	COG0406	alpha-ribazole phosphatase activity
BIF_RS03745	COG0598	Magnesium transport protein CorA
BIF_RS03775	COG0802	atpase or kinase
BIF_RS03830	COG0516	GMP reductase activity
BIF_RS03840	COG1022	Amp-dependent synthetase and ligase
BIF_RS03870	COG0575	Belongs to the CDS family
BIF_RS03910	COG1573	uracil-dna glycosylase
BIF_RS03925	COG0133	tryptophan synthase activity
BIF_RS03940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIF_RS03955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIF_RS03975	COG1716	ATPase activity
BIF_RS03990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIF_RS03995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIF_RS04045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIF_RS04065	COG0045	succinate-CoA ligase (ADP-forming) activity
BIF_RS04100	COG0438	transferase activity, transferring glycosyl groups
BIF_RS04105	COG1560	Kdo2-lipid A biosynthetic process
BIF_RS04120	COG0488	(ABC) transporter
BIF_RS04130	COG0456	acetyltransferase
BIF_RS04195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIF_RS04205	COG0436	Aminotransferase
BIF_RS04215	COG0436	Aminotransferase
BIF_RS04220	COG0561	phosphatase activity
BIF_RS04225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIF_RS04250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIF_RS04280	COG0488	(ABC) transporter
BIF_RS04305	COG0450	alkyl hydroperoxide reductase
BIF_RS04315	COG0583	DNA-binding transcription factor activity
BIF_RS04355	COG0167	dihydroorotate dehydrogenase activity
BIF_RS04365	COG0284	orotidine-5'-phosphate decarboxylase activity
BIF_RS04370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIF_RS04395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BIF_RS04415	COG1119	ATPase activity
BIF_RS04420	COG0297	glycogen (starch) synthase activity
BIF_RS04440	COG0069	glutamate synthase activity
BIF_RS04440	COG0067	glutamate synthase
BIF_RS04440	COG0070	glutamate synthase
BIF_RS04460	COG2860	membrane
BIF_RS04465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIF_RS04490	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BIF_RS04515	COG1702	phosphate starvation-inducible protein PhoH
BIF_RS04520	COG0537	adenosine 5'-monophosphoramidase activity
BIF_RS04525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BIF_RS04550	COG2151	metal-sulfur cluster biosynthetic enzyme
BIF_RS04555	COG0822	iron-sulfur transferase activity
BIF_RS04565	COG0396	ATPase activity
BIF_RS04570	COG0719	Fe-S assembly protein
BIF_RS04580	COG1376	ErfK ybiS ycfS ynhG family protein
BIF_RS04595	COG1523	belongs to the glycosyl hydrolase 13 family
BIF_RS04645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BIF_RS04690	COG0588	phosphoglycerate mutase activity
BIF_RS04695	COG1950	PFAM Membrane protein of
BIF_RS04730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BIF_RS04745	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BIF_RS04760	COG1131	(ABC) transporter
BIF_RS04765	COG1725	Transcriptional regulator
BIF_RS04775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BIF_RS04800	COG0563	adenylate kinase activity
BIF_RS04815	COG3039	Transposase
BIF_RS04835	COG0280	phosphate acetyltransferase
BIF_RS04835	COG0857	belongs to the CobB CobQ family
BIF_RS04840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIF_RS04870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIF_RS04885	COG0494	nUDIX hydrolase
BIF_RS04895	COG0469	pyruvate kinase activity
BIF_RS04910	COG0237	dephospho-CoA kinase activity
BIF_RS04915	COG0539	negative regulation of cytoplasmic translation
BIF_RS04925	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIF_RS04930	COG1121	(ABC) transporter
BIF_RS04945	COG1329	Transcriptional regulator
BIF_RS04955	COG0745	RESPONSE REGULATOR receiver
BIF_RS04960	COG2205	protein histidine kinase activity
BIF_RS04990	COG1316	TRANSCRIPTIONal
BIF_RS04995	COG1316	TRANSCRIPTIONal
BIF_RS05020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIF_RS05030	COG1760	l-serine dehydratase
BIF_RS05075	COG1116	anion transmembrane transporter activity
BIF_RS05100	COG1472	Belongs to the glycosyl hydrolase 3 family
BIF_RS05110	COG1966	Carbon starvation protein
BIF_RS05150	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BIF_RS05150	COG1918	ferrous iron import across plasma membrane
BIF_RS05170	COG0363	glucosamine-6-phosphate deaminase activity
BIF_RS05175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIF_RS05180	COG3340	Belongs to the peptidase S51 family
BIF_RS05185	COG1114	Component of the transport system for branched-chain amino acids
BIF_RS05215	COG2233	PERMEase
BIF_RS05235	COG0012	GTP binding
BIF_RS05240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIF_RS05250	COG4585	Histidine kinase
BIF_RS05255	COG2197	response regulator
BIF_RS05265	COG0577	efflux transmembrane transporter activity
BIF_RS05265	COG1136	(ABC) transporter
BIF_RS05275	COG1122	ATPase activity
BIF_RS05280	COG2873	o-acetylhomoserine
BIF_RS05310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BIF_RS05375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BIF_RS05380	COG1882	Formate acetyltransferase
BIF_RS05395	COG1473	amidohydrolase
BIF_RS05400	COG2011	ABC-type metal ion transport system permease component
BIF_RS05410	COG1464	Belongs to the NlpA lipoprotein family
BIF_RS05415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIF_RS05420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIF_RS05445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIF_RS05450	COG4975	Glucose uptake
BIF_RS05455	COG1201	RNA secondary structure unwinding
BIF_RS05480	COG0187	DNA topoisomerase II activity
BIF_RS05485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIF_RS05495	COG0142	geranyltranstransferase activity
BIF_RS05515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIF_RS05525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BIF_RS05550	COG1396	sequence-specific DNA binding
BIF_RS05560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIF_RS05580	COG2357	RelA SpoT domain protein
BIF_RS05585	COG0670	Belongs to the BI1 family
BIF_RS05590	COG3804	dihydrodipicolinate reductase
BIF_RS05605	COG1131	(ABC) transporter
BIF_RS05610	COG4585	Histidine kinase
BIF_RS05615	COG2197	response regulator
BIF_RS05630	COG0366	Alpha amylase catalytic
BIF_RS05635	COG2182	Extracellular solute-binding protein
BIF_RS05650	COG0110	maltose O-acetyltransferase activity
BIF_RS05660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BIF_RS05690	COG0708	Exodeoxyribonuclease III
BIF_RS05705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIF_RS05710	COG0601	transmembrane transport
BIF_RS05715	COG4166	transmembrane transport
BIF_RS05725	COG1136	(ABC) transporter
BIF_RS05730	COG0577	efflux transmembrane transporter activity
BIF_RS05740	COG0287	Prephenate dehydrogenase
BIF_RS05755	COG1217	gtp-binding protein TYPA
BIF_RS05760	COG0477	Major facilitator Superfamily
BIF_RS05790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIF_RS05805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIF_RS05815	COG2017	converts alpha-aldose to the beta-anomer
BIF_RS05840	COG0285	dihydrofolate synthase activity
BIF_RS05860	COG0006	proline dipeptidase activity
BIF_RS05865	COG2816	NAD+ diphosphatase activity
BIF_RS05885	COG0582	viral genome integration into host DNA
BIF_RS05970	COG0601	transmembrane transport
BIF_RS06010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIF_RS06020	COG0768	penicillin binding
BIF_RS06045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIF_RS06065	COG1230	cation diffusion facilitator family transporter
BIF_RS06075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIF_RS06085	COG1643	Atp-dependent helicase
BIF_RS06130	COG0587	DNA-directed DNA polymerase activity
BIF_RS06165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIF_RS06210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIF_RS06215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIF_RS06220	COG1957	nucleoside hydrolase
BIF_RS06275	COG3480	Lon protease (S16) C-terminal proteolytic domain
BIF_RS06300	COG0613	PHP domain protein
BIF_RS06310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BIF_RS06335	COG1126	abc transporter atp-binding protein
BIF_RS06340	COG0765	amino acid transport
BIF_RS06345	COG0765	amino acid transport
BIF_RS06350	COG0436	Aminotransferase
BIF_RS06355	COG2011	ABC-type metal ion transport system permease component
BIF_RS06365	COG1464	Belongs to the NlpA lipoprotein family
BIF_RS06370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIF_RS06430	COG4166	transmembrane transport
BIF_RS06435	COG2814	Major facilitator Superfamily
BIF_RS06440	COG1842	Phage shock protein A
BIF_RS06460	COG2365	Tyrosine phosphatase family
BIF_RS06475	COG1132	(ABC) transporter
BIF_RS06480	COG1132	(ABC) transporter
BIF_RS06530	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BIF_RS06535	COG1518	maintenance of DNA repeat elements
BIF_RS06535	COG1468	defense response to virus
BIF_RS06570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIF_RS06570	COG1328	CTP reductase activity
BIF_RS06575	COG1570	exodeoxyribonuclease VII activity
BIF_RS06580	COG1722	exodeoxyribonuclease VII activity
BIF_RS06600	COG0436	Aminotransferase
BIF_RS06635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIF_RS06660	COG0210	DNA helicase
BIF_RS06680	COG0714	Associated with various cellular activities
BIF_RS06720	COG1194	a g-specific adenine glycosylase
BIF_RS06725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BIF_RS06745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIF_RS06755	COG1349	DNA-binding transcription factor activity
BIF_RS06760	COG1216	Glycosyl transferase, family 2
BIF_RS06765	COG0167	dihydroorotate dehydrogenase activity
BIF_RS06770	COG1902	pentaerythritol trinitrate reductase activity
BIF_RS06775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIF_RS06775	COG4499	WXG100 protein secretion system (Wss), protein YukC
BIF_RS06785	COG0095	Lipoate-protein ligase
BIF_RS06830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIF_RS06865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BIF_RS06875	COG1088	dTDP-glucose 4,6-dehydratase activity
BIF_RS06895	COG1216	Glycosyl transferase, family 2
BIF_RS06895	COG1442	glycosyl transferase family 8
BIF_RS06945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BIF_RS06955	COG2814	Major facilitator Superfamily
BIF_RS07010	COG4988	ABC transporter
BIF_RS07025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIF_RS07035	COG0489	protein tyrosine kinase activity
BIF_RS07050	COG0083	homoserine kinase activity
BIF_RS07055	COG0460	homoserine dehydrogenase
BIF_RS07060	COG0019	diaminopimelate decarboxylase activity
BIF_RS07075	COG0251	oxidation-reduction process
BIF_RS07080	COG0395	ABC-type sugar transport system, permease component
BIF_RS07085	COG3459	Glycosyltransferase 36 associated
BIF_RS07110	COG0545	Peptidyl-prolyl cis-trans isomerase
BIF_RS07120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BIF_RS07155	COG0356	it plays a direct role in the translocation of protons across the membrane
BIF_RS07165	COG0477	Major facilitator Superfamily
BIF_RS07215	COG0582	viral genome integration into host DNA
BIF_RS07230	COG0679	Auxin Efflux Carrier
BIF_RS07235	COG0028	Belongs to the TPP enzyme family
BIF_RS07260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BIF_RS07270	COG0745	RESPONSE REGULATOR receiver
BIF_RS07280	COG0747	negative chemotaxis
BIF_RS07295	COG1605	Chorismate mutase
BIF_RS07295	COG0287	Prephenate dehydrogenase
BIF_RS07360	COG2217	Heavy metal translocating P-type atpase
BIF_RS07370	COG0179	Fumarylacetoacetate (FAA) hydrolase
BIF_RS07395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIF_RS07410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIF_RS07455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIF_RS07470	COG1609	Transcriptional regulator
BIF_RS07505	COG1368	sulfuric ester hydrolase activity
BIF_RS07510	COG1368	sulfuric ester hydrolase activity
BIF_RS07515	COG1216	Glycosyl transferase, family 2
BIF_RS07565	COG1216	Glycosyl transferase, family 2
BIF_RS07620	COG0084	hydrolase, TatD family'
BIF_RS07635	COG1132	(ABC) transporter
BIF_RS07640	COG1132	(ABC) transporter
BIF_RS07675	COG0586	Pfam SNARE associated Golgi protein
BIF_RS07695	COG1309	transcriptional regulator
BIF_RS07700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIF_RS07705	COG0789	Transcriptional regulator
BIF_RS07710	COG0484	heat shock protein binding
BIF_RS07740	COG1523	belongs to the glycosyl hydrolase 13 family
BIF_RS07745	COG3833	ABC-type maltose transport systems, permease component
BIF_RS07750	COG1175	transmembrane transport
BIF_RS07760	COG0366	Alpha amylase catalytic
BIF_RS07785	COG1609	Transcriptional regulator
BIF_RS07795	COG0366	Alpha amylase catalytic
BIF_RS07810	COG0778	Nitroreductase
BIF_RS07820	COG2814	Major facilitator Superfamily
BIF_RS07880	COG1609	Transcriptional regulator
BIF_RS07885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BIF_RS07890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BIF_RS07895	COG0366	Alpha amylase catalytic
BIF_RS07910	COG0395	ABC-type sugar transport system, permease component
BIF_RS07915	COG1175	transmembrane transport
BIF_RS07935	COG0590	tRNA wobble adenosine to inosine editing
BIF_RS07935	COG0037	tRNA processing
BIF_RS07940	COG0025	NhaP-type Na H and K H
BIF_RS07960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BIF_RS07965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIF_RS07975	COG3842	ATPase activity
BIF_RS07980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BIF_RS08000	COG3583	domain protein
BIF_RS08020	COG0617	tRNA 3'-terminal CCA addition
BIF_RS08040	COG0492	ferredoxin-NADP+ reductase activity
BIF_RS08045	COG1475	DNA binding
BIF_RS08050	COG1192	Involved in chromosome partitioning
BIF_RS08060	COG1847	R3H domain protein