locus-tag	class	description
K7H00_RS00010	COG0592	DNA-directed DNA polymerase activity
K7H00_RS00025	COG0187	DNA topoisomerase II activity
K7H00_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K7H00_RS00045	COG1272	protein, Hemolysin III
K7H00_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K7H00_RS00055	COG2814	Major facilitator Superfamily
K7H00_RS00070	COG1970	mechanosensitive ion channel activity
K7H00_RS00110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K7H00_RS00115	COG2226	methyltransferase
K7H00_RS00220	COG0583	DNA-binding transcription factor activity
K7H00_RS00235	COG3231	kanamycin kinase activity
K7H00_RS00275	COG0783	Belongs to the Dps family
K7H00_RS00280	COG1253	flavin adenine dinucleotide binding
K7H00_RS00285	COG0288	reversible hydration of carbon dioxide
K7H00_RS00290	COG1609	Transcriptional regulator
K7H00_RS00315	COG1609	Transcriptional regulator
K7H00_RS00320	COG3534	alpha-L-arabinofuranosidase
K7H00_RS00340	COG0656	L-ascorbic acid biosynthetic process
K7H00_RS00345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K7H00_RS00360	COG0180	Tryptophanyl-tRNA synthetase
K7H00_RS00375	COG0058	SHG alpha-glucan phosphorylase activity
K7H00_RS00405	COG3764	Sortase (surface protein transpeptidase)
K7H00_RS00420	COG0515	serine threonine protein kinase
K7H00_RS00425	COG0768	penicillin binding
K7H00_RS00455	COG0697	spore germination
K7H00_RS00470	COG2226	methyltransferase
K7H00_RS00475	COG2261	transglycosylase associated protein
K7H00_RS00480	COG2261	transglycosylase associated protein
K7H00_RS00495	COG2217	Heavy metal translocating P-type atpase
K7H00_RS00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7H00_RS00515	COG0343	queuine tRNA-ribosyltransferase activity
K7H00_RS00540	COG2814	Major facilitator Superfamily
K7H00_RS00555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7H00_RS00585	COG0667	Aldo Keto reductase
K7H00_RS00620	COG1063	alcohol dehydrogenase
K7H00_RS00625	COG0583	DNA-binding transcription factor activity
K7H00_RS00635	COG0191	fructose-bisphosphate aldolase activity
K7H00_RS00645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7H00_RS00690	COG2211	Major facilitator Superfamily
K7H00_RS00740	COG0477	Major facilitator Superfamily
K7H00_RS00795	COG1132	(ABC) transporter
K7H00_RS00800	COG0390	transport system, permease component
K7H00_RS00805	COG1113	amino acid transport
K7H00_RS00810	COG0577	efflux transmembrane transporter activity
K7H00_RS00810	COG1136	(ABC) transporter
K7H00_RS00820	COG1113	amino acid transport
K7H00_RS00835	COG0577	efflux transmembrane transporter activity
K7H00_RS00845	COG1846	Transcriptional regulator
K7H00_RS00865	COG0671	phosphoesterase, PA-phosphatase related
K7H00_RS00870	COG0110	maltose O-acetyltransferase activity
K7H00_RS00910	COG1129	ABC transporter
K7H00_RS00945	COG1309	transcriptional regulator
K7H00_RS00965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K7H00_RS00975	COG0305	Participates in initiation and elongation during chromosome replication
K7H00_RS00980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K7H00_RS01015	COG0406	alpha-ribazole phosphatase activity
K7H00_RS01015	COG0494	nUDIX hydrolase
K7H00_RS01100	COG1260	myo-inositol-1-phosphate synthase
K7H00_RS01115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7H00_RS01115	COG1754	DNA topoisomerase type I activity
K7H00_RS01175	COG0406	alpha-ribazole phosphatase activity
K7H00_RS01230	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7H00_RS01235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K7H00_RS01285	COG0436	Aminotransferase
K7H00_RS01300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K7H00_RS01300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K7H00_RS01310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K7H00_RS01325	COG0742	ribosomal rna small subunit methyltransferase
K7H00_RS01340	COG1837	Belongs to the UPF0109 family
K7H00_RS01395	COG0440	acetolactate synthase activity
K7H00_RS01435	COG0667	Aldo Keto reductase
K7H00_RS01500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K7H00_RS01520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7H00_RS01525	COG1530	ribonuclease E activity
K7H00_RS01550	COG0436	Aminotransferase
K7H00_RS01585	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K7H00_RS01585	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K7H00_RS01590	COG1268	BioY protein
K7H00_RS01595	COG4770	biotin carboxylase activity
K7H00_RS01600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7H00_RS01625	COG0039	L-malate dehydrogenase activity
K7H00_RS01640	COG1704	LemA family
K7H00_RS01650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7H00_RS01655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7H00_RS01675	COG0826	peptidase U32
K7H00_RS01690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K7H00_RS01700	COG3579	cysteine-type endopeptidase activity
K7H00_RS01705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K7H00_RS01710	COG2755	lipolytic protein G-D-S-L family
K7H00_RS01710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K7H00_RS01715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K7H00_RS01720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K7H00_RS01730	COG0745	RESPONSE REGULATOR receiver
K7H00_RS01745	COG0581	inorganic phosphate transmembrane transporter activity
K7H00_RS01755	COG2252	PERMEase
K7H00_RS01840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K7H00_RS01845	COG0531	amino acid
K7H00_RS01860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K7H00_RS01870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7H00_RS01875	COG1739	Uncharacterized protein family UPF0029
K7H00_RS01910	COG1012	belongs to the aldehyde dehydrogenase family
K7H00_RS01910	COG1454	alcohol dehydrogenase
K7H00_RS01970	COG0255	Belongs to the universal ribosomal protein uL29 family
K7H00_RS02105	COG0196	riboflavin kinase activity
K7H00_RS02130	COG0328	RNA-DNA hybrid ribonuclease activity
K7H00_RS02145	COG1597	lipid kinase activity
K7H00_RS02145	COG1803	Methylglyoxal synthase
K7H00_RS02170	COG2197	response regulator
K7H00_RS02190	COG0626	cystathionine gamma-synthase activity
K7H00_RS02200	COG2873	o-acetylhomoserine
K7H00_RS02210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K7H00_RS02225	COG3579	cysteine-type endopeptidase activity
K7H00_RS02230	COG0531	amino acid
K7H00_RS02240	COG1113	amino acid transport
K7H00_RS02255	COG4716	Myosin-crossreactive antigen
K7H00_RS02260	COG1063	alcohol dehydrogenase
K7H00_RS02265	COG3321	synthase
K7H00_RS02265	COG0604	alcohol dehydrogenase
K7H00_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
K7H00_RS02280	COG5002	protein histidine kinase activity
K7H00_RS02285	COG0704	Plays a role in the regulation of phosphate uptake
K7H00_RS02290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K7H00_RS02295	COG1705	Flagellar rod assembly protein muramidase FlgJ
K7H00_RS02295	COG3942	CHAP domain
K7H00_RS02300	COG1388	LysM domain
K7H00_RS02300	COG0791	NLP P60 protein
K7H00_RS02320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K7H00_RS02325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7H00_RS02330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K7H00_RS02405	COG3189	MarR family transcriptional regulator
K7H00_RS02415	COG3250	beta-galactosidase activity
K7H00_RS02420	COG1609	Transcriptional regulator
K7H00_RS02455	COG0395	ABC-type sugar transport system, permease component
K7H00_RS02485	COG1216	Glycosyl transferase, family 2
K7H00_RS02490	COG0628	permease
K7H00_RS02525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7H00_RS02540	COG1946	Acyl-CoA thioesterase
K7H00_RS02550	COG0242	peptide deformylase activity
K7H00_RS02555	COG2873	o-acetylhomoserine
K7H00_RS02590	COG3507	Belongs to the glycosyl hydrolase 43 family
K7H00_RS02605	COG1175	transmembrane transport
K7H00_RS02615	COG3507	Belongs to the glycosyl hydrolase 43 family
K7H00_RS02625	COG2272	Belongs to the type-B carboxylesterase lipase family
K7H00_RS02635	COG1070	Carbohydrate kinase
K7H00_RS02640	COG1940	carbohydrate kinase activity
K7H00_RS02660	COG0009	L-threonylcarbamoyladenylate synthase
K7H00_RS02680	COG0561	phosphatase activity
K7H00_RS02685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K7H00_RS02705	COG3590	peptidase
K7H00_RS02715	COG0024	Methionine aminopeptidase
K7H00_RS02720	COG0372	Belongs to the citrate synthase family
K7H00_RS02735	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K7H00_RS02740	COG2884	Cell division ATP-binding protein ftsE
K7H00_RS02750	COG3942	CHAP domain
K7H00_RS02750	COG1388	LysM domain
K7H00_RS02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7H00_RS02770	COG0765	amino acid transport
K7H00_RS02785	COG2205	protein histidine kinase activity
K7H00_RS02785	COG0784	Response regulator, receiver
K7H00_RS02785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7H00_RS02785	COG2198	Histidine kinase
K7H00_RS02790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7H00_RS02810	COG0747	negative chemotaxis
K7H00_RS02815	COG0601	transmembrane transport
K7H00_RS02820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7H00_RS02830	COG4172	Belongs to the ABC transporter superfamily
K7H00_RS02845	COG0514	ATP-dependent DNA helicase (RecQ)
K7H00_RS02925	COG0371	Dehydrogenase
K7H00_RS02940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K7H00_RS02945	COG0358	DNA primase activity
K7H00_RS02950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K7H00_RS02960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K7H00_RS02965	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K7H00_RS02970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K7H00_RS02975	COG0735	belongs to the Fur family
K7H00_RS02980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K7H00_RS02985	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K7H00_RS02990	COG0151	Belongs to the GarS family
K7H00_RS03005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K7H00_RS03060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K7H00_RS03140	COG0284	orotidine-5'-phosphate decarboxylase activity
K7H00_RS03165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7H00_RS03180	COG0560	Phosphoserine phosphatase
K7H00_RS03185	COG0586	Pfam SNARE associated Golgi protein
K7H00_RS03195	COG4122	O-methyltransferase activity
K7H00_RS03225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K7H00_RS03265	COG0714	Associated with various cellular activities
K7H00_RS03280	COG1278	Cold shock
K7H00_RS03300	COG0745	RESPONSE REGULATOR receiver
K7H00_RS03305	COG2205	protein histidine kinase activity
K7H00_RS03310	COG1278	Cold shock
K7H00_RS03345	COG1196	nuclear chromosome segregation
K7H00_RS03355	COG1126	abc transporter atp-binding protein
K7H00_RS03360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7H00_RS03365	COG0765	amino acid transport
K7H00_RS03370	COG0765	amino acid transport
K7H00_RS03375	COG2326	polyphosphate kinase activity
K7H00_RS03390	COG2814	Major facilitator Superfamily
K7H00_RS03395	COG1022	Amp-dependent synthetase and ligase
K7H00_RS03400	COG3328	transposase activity
K7H00_RS03430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K7H00_RS03440	COG0656	L-ascorbic acid biosynthetic process
K7H00_RS03465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K7H00_RS03485	COG0489	protein tyrosine kinase activity
K7H00_RS03485	COG2151	metal-sulfur cluster biosynthetic enzyme
K7H00_RS03490	COG4721	ABC-type cobalt transport system, permease component
K7H00_RS03515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7H00_RS03540	COG1136	(ABC) transporter
K7H00_RS03550	COG4721	ABC-type cobalt transport system, permease component
K7H00_RS03555	COG4172	Belongs to the ABC transporter superfamily
K7H00_RS03560	COG1136	(ABC) transporter
K7H00_RS03565	COG0577	efflux transmembrane transporter activity
K7H00_RS03575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7H00_RS03665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K7H00_RS03670	COG0569	domain protein
K7H00_RS03685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7H00_RS03705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K7H00_RS03725	COG0799	negative regulation of ribosome biogenesis
K7H00_RS03755	COG0406	alpha-ribazole phosphatase activity
K7H00_RS03760	COG0598	Magnesium transport protein CorA
K7H00_RS03790	COG0802	atpase or kinase
K7H00_RS03845	COG0516	GMP reductase activity
K7H00_RS03855	COG1022	Amp-dependent synthetase and ligase
K7H00_RS03885	COG0575	Belongs to the CDS family
K7H00_RS03925	COG1573	uracil-dna glycosylase
K7H00_RS03940	COG0133	tryptophan synthase activity
K7H00_RS03955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K7H00_RS03970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K7H00_RS03990	COG1716	ATPase activity
K7H00_RS04005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7H00_RS04010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7H00_RS04060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K7H00_RS04085	COG0045	succinate-CoA ligase (ADP-forming) activity
K7H00_RS04120	COG0438	transferase activity, transferring glycosyl groups
K7H00_RS04125	COG1560	Kdo2-lipid A biosynthetic process
K7H00_RS04140	COG0488	(ABC) transporter
K7H00_RS04150	COG0456	acetyltransferase
K7H00_RS04215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K7H00_RS04225	COG0436	Aminotransferase
K7H00_RS04235	COG0436	Aminotransferase
K7H00_RS04240	COG0561	phosphatase activity
K7H00_RS04245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K7H00_RS04270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K7H00_RS04300	COG0488	(ABC) transporter
K7H00_RS04325	COG0450	alkyl hydroperoxide reductase
K7H00_RS04335	COG0583	DNA-binding transcription factor activity
K7H00_RS04375	COG0167	dihydroorotate dehydrogenase activity
K7H00_RS04385	COG0284	orotidine-5'-phosphate decarboxylase activity
K7H00_RS04390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7H00_RS04415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K7H00_RS04435	COG1119	ATPase activity
K7H00_RS04440	COG0297	glycogen (starch) synthase activity
K7H00_RS04460	COG0067	glutamate synthase
K7H00_RS04460	COG0069	glutamate synthase activity
K7H00_RS04460	COG0070	glutamate synthase
K7H00_RS04480	COG2860	membrane
K7H00_RS04485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K7H00_RS04510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K7H00_RS04535	COG1702	phosphate starvation-inducible protein PhoH
K7H00_RS04540	COG0537	adenosine 5'-monophosphoramidase activity
K7H00_RS04545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K7H00_RS04570	COG2151	metal-sulfur cluster biosynthetic enzyme
K7H00_RS04575	COG0822	iron-sulfur transferase activity
K7H00_RS04585	COG0396	ATPase activity
K7H00_RS04590	COG0719	Fe-S assembly protein
K7H00_RS04600	COG1376	ErfK ybiS ycfS ynhG family protein
K7H00_RS04615	COG1523	belongs to the glycosyl hydrolase 13 family
K7H00_RS04665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K7H00_RS04710	COG0588	phosphoglycerate mutase activity
K7H00_RS04715	COG1950	PFAM Membrane protein of
K7H00_RS04745	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K7H00_RS04760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K7H00_RS04775	COG1131	(ABC) transporter
K7H00_RS04780	COG1725	Transcriptional regulator
K7H00_RS04790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K7H00_RS04815	COG0563	adenylate kinase activity
K7H00_RS04830	COG3039	Transposase
K7H00_RS04850	COG0857	belongs to the CobB CobQ family
K7H00_RS04850	COG0280	phosphate acetyltransferase
K7H00_RS04855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K7H00_RS04885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K7H00_RS04900	COG0494	nUDIX hydrolase
K7H00_RS04910	COG0469	pyruvate kinase activity
K7H00_RS04925	COG0237	dephospho-CoA kinase activity
K7H00_RS04930	COG0539	negative regulation of cytoplasmic translation
K7H00_RS04940	COG0803	Belongs to the bacterial solute-binding protein 9 family
K7H00_RS04945	COG1121	(ABC) transporter
K7H00_RS04960	COG1329	Transcriptional regulator
K7H00_RS04970	COG0745	RESPONSE REGULATOR receiver
K7H00_RS04975	COG2205	protein histidine kinase activity
K7H00_RS05005	COG1316	TRANSCRIPTIONal
K7H00_RS05010	COG1316	TRANSCRIPTIONal
K7H00_RS05035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7H00_RS05045	COG1760	l-serine dehydratase
K7H00_RS05090	COG1116	anion transmembrane transporter activity
K7H00_RS05115	COG1472	Belongs to the glycosyl hydrolase 3 family
K7H00_RS05125	COG1966	Carbon starvation protein
K7H00_RS05165	COG1918	ferrous iron import across plasma membrane
K7H00_RS05165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K7H00_RS05185	COG0363	glucosamine-6-phosphate deaminase activity
K7H00_RS05190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K7H00_RS05195	COG3340	Belongs to the peptidase S51 family
K7H00_RS05200	COG1114	Component of the transport system for branched-chain amino acids
K7H00_RS05230	COG2233	PERMEase
K7H00_RS05250	COG0012	GTP binding
K7H00_RS05255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K7H00_RS05265	COG4585	Histidine kinase
K7H00_RS05270	COG2197	response regulator
K7H00_RS05280	COG1136	(ABC) transporter
K7H00_RS05280	COG0577	efflux transmembrane transporter activity
K7H00_RS05290	COG1122	ATPase activity
K7H00_RS05295	COG2873	o-acetylhomoserine
K7H00_RS05325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K7H00_RS05390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K7H00_RS05395	COG1882	Formate acetyltransferase
K7H00_RS05410	COG1473	amidohydrolase
K7H00_RS05415	COG2011	ABC-type metal ion transport system permease component
K7H00_RS05425	COG1464	Belongs to the NlpA lipoprotein family
K7H00_RS05430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K7H00_RS05435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7H00_RS05460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K7H00_RS05465	COG4975	Glucose uptake
K7H00_RS05470	COG1201	RNA secondary structure unwinding
K7H00_RS05495	COG0187	DNA topoisomerase II activity
K7H00_RS05500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7H00_RS05510	COG0142	geranyltranstransferase activity
K7H00_RS05530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K7H00_RS05540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K7H00_RS05565	COG1396	sequence-specific DNA binding
K7H00_RS05575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K7H00_RS05595	COG2357	RelA SpoT domain protein
K7H00_RS05600	COG0670	Belongs to the BI1 family
K7H00_RS05605	COG3804	dihydrodipicolinate reductase
K7H00_RS05620	COG1131	(ABC) transporter
K7H00_RS05625	COG4585	Histidine kinase
K7H00_RS05630	COG2197	response regulator
K7H00_RS05645	COG0366	Alpha amylase catalytic
K7H00_RS05650	COG2182	Extracellular solute-binding protein
K7H00_RS05665	COG0110	maltose O-acetyltransferase activity
K7H00_RS05675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K7H00_RS05705	COG0708	Exodeoxyribonuclease III
K7H00_RS05720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7H00_RS05725	COG0601	transmembrane transport
K7H00_RS05730	COG4166	transmembrane transport
K7H00_RS05740	COG1136	(ABC) transporter
K7H00_RS05745	COG0577	efflux transmembrane transporter activity
K7H00_RS05755	COG0287	Prephenate dehydrogenase
K7H00_RS05770	COG1217	gtp-binding protein TYPA
K7H00_RS05775	COG0477	Major facilitator Superfamily
K7H00_RS05805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K7H00_RS05820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K7H00_RS05830	COG2017	converts alpha-aldose to the beta-anomer
K7H00_RS05855	COG0285	dihydrofolate synthase activity
K7H00_RS05875	COG0006	proline dipeptidase activity
K7H00_RS05880	COG2816	NAD+ diphosphatase activity
K7H00_RS05900	COG0582	viral genome integration into host DNA
K7H00_RS05985	COG0601	transmembrane transport
K7H00_RS06025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K7H00_RS06035	COG0768	penicillin binding
K7H00_RS06060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K7H00_RS06080	COG1230	cation diffusion facilitator family transporter
K7H00_RS06090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K7H00_RS06100	COG1643	Atp-dependent helicase
K7H00_RS06145	COG0587	DNA-directed DNA polymerase activity
K7H00_RS06180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K7H00_RS06225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K7H00_RS06230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K7H00_RS06235	COG1957	nucleoside hydrolase
K7H00_RS06290	COG3480	Lon protease (S16) C-terminal proteolytic domain
K7H00_RS06315	COG0613	PHP domain protein
K7H00_RS06325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K7H00_RS06350	COG1126	abc transporter atp-binding protein
K7H00_RS06355	COG0765	amino acid transport
K7H00_RS06360	COG0765	amino acid transport
K7H00_RS06365	COG0436	Aminotransferase
K7H00_RS06370	COG2011	ABC-type metal ion transport system permease component
K7H00_RS06380	COG1464	Belongs to the NlpA lipoprotein family
K7H00_RS06385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K7H00_RS06445	COG4166	transmembrane transport
K7H00_RS06450	COG2814	Major facilitator Superfamily
K7H00_RS06455	COG1842	Phage shock protein A
K7H00_RS06475	COG2365	Tyrosine phosphatase family
K7H00_RS06490	COG1132	(ABC) transporter
K7H00_RS06495	COG1132	(ABC) transporter
K7H00_RS06545	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K7H00_RS06550	COG1518	maintenance of DNA repeat elements
K7H00_RS06550	COG1468	defense response to virus
K7H00_RS06585	COG1328	CTP reductase activity
K7H00_RS06585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K7H00_RS06590	COG1570	exodeoxyribonuclease VII activity
K7H00_RS06595	COG1722	exodeoxyribonuclease VII activity
K7H00_RS06615	COG0436	Aminotransferase
K7H00_RS06650	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K7H00_RS06675	COG0210	DNA helicase
K7H00_RS06695	COG0714	Associated with various cellular activities
K7H00_RS06735	COG1194	a g-specific adenine glycosylase
K7H00_RS06740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K7H00_RS06760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K7H00_RS06770	COG1349	DNA-binding transcription factor activity
K7H00_RS06775	COG1216	Glycosyl transferase, family 2
K7H00_RS06780	COG0167	dihydroorotate dehydrogenase activity
K7H00_RS06785	COG1902	pentaerythritol trinitrate reductase activity
K7H00_RS06790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7H00_RS06790	COG4499	WXG100 protein secretion system (Wss), protein YukC
K7H00_RS06800	COG0095	Lipoate-protein ligase
K7H00_RS06845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7H00_RS06880	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K7H00_RS06890	COG1088	dTDP-glucose 4,6-dehydratase activity
K7H00_RS06910	COG1216	Glycosyl transferase, family 2
K7H00_RS06910	COG1442	glycosyl transferase family 8
K7H00_RS06960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K7H00_RS06970	COG2814	Major facilitator Superfamily
K7H00_RS07025	COG4988	ABC transporter
K7H00_RS07050	COG0489	protein tyrosine kinase activity
K7H00_RS07065	COG0083	homoserine kinase activity
K7H00_RS07070	COG0460	homoserine dehydrogenase
K7H00_RS07075	COG0019	diaminopimelate decarboxylase activity
K7H00_RS07090	COG0251	oxidation-reduction process
K7H00_RS07095	COG0395	ABC-type sugar transport system, permease component
K7H00_RS07100	COG3459	Glycosyltransferase 36 associated
K7H00_RS07125	COG0545	Peptidyl-prolyl cis-trans isomerase
K7H00_RS07135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K7H00_RS07170	COG0356	it plays a direct role in the translocation of protons across the membrane
K7H00_RS07180	COG0477	Major facilitator Superfamily
K7H00_RS07230	COG0582	viral genome integration into host DNA
K7H00_RS07245	COG0679	Auxin Efflux Carrier
K7H00_RS07250	COG0028	Belongs to the TPP enzyme family
K7H00_RS07275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K7H00_RS07285	COG0745	RESPONSE REGULATOR receiver
K7H00_RS07295	COG0747	negative chemotaxis
K7H00_RS07310	COG0287	Prephenate dehydrogenase
K7H00_RS07310	COG1605	Chorismate mutase
K7H00_RS07375	COG2217	Heavy metal translocating P-type atpase
K7H00_RS07385	COG0179	Fumarylacetoacetate (FAA) hydrolase
K7H00_RS07410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K7H00_RS07425	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K7H00_RS07470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7H00_RS07485	COG1609	Transcriptional regulator
K7H00_RS07520	COG1368	sulfuric ester hydrolase activity
K7H00_RS07525	COG1368	sulfuric ester hydrolase activity
K7H00_RS07530	COG1216	Glycosyl transferase, family 2
K7H00_RS07580	COG1216	Glycosyl transferase, family 2
K7H00_RS07635	COG0084	hydrolase, TatD family'
K7H00_RS07650	COG1132	(ABC) transporter
K7H00_RS07655	COG1132	(ABC) transporter
K7H00_RS07690	COG0586	Pfam SNARE associated Golgi protein
K7H00_RS07710	COG1309	transcriptional regulator
K7H00_RS07715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7H00_RS07720	COG0789	Transcriptional regulator
K7H00_RS07725	COG0484	heat shock protein binding
K7H00_RS07755	COG1523	belongs to the glycosyl hydrolase 13 family
K7H00_RS07760	COG3833	ABC-type maltose transport systems, permease component
K7H00_RS07765	COG1175	transmembrane transport
K7H00_RS07775	COG0366	Alpha amylase catalytic
K7H00_RS07800	COG1609	Transcriptional regulator
K7H00_RS07810	COG0366	Alpha amylase catalytic
K7H00_RS07825	COG0778	Nitroreductase
K7H00_RS07835	COG2814	Major facilitator Superfamily
K7H00_RS07865	COG1609	Transcriptional regulator
K7H00_RS07870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K7H00_RS07875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K7H00_RS07880	COG0366	Alpha amylase catalytic
K7H00_RS07895	COG0395	ABC-type sugar transport system, permease component
K7H00_RS07900	COG1175	transmembrane transport
K7H00_RS07920	COG0037	tRNA processing
K7H00_RS07920	COG0590	tRNA wobble adenosine to inosine editing
K7H00_RS07925	COG0025	NhaP-type Na H and K H
K7H00_RS07945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K7H00_RS07950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7H00_RS07960	COG3842	ATPase activity
K7H00_RS07965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K7H00_RS07985	COG3583	domain protein
K7H00_RS08005	COG0617	tRNA 3'-terminal CCA addition
K7H00_RS08025	COG0492	ferredoxin-NADP+ reductase activity
K7H00_RS08030	COG1475	DNA binding
K7H00_RS08035	COG1192	Involved in chromosome partitioning
K7H00_RS08045	COG1847	R3H domain protein