locus-tag	class	description
BL12_RS00010	COG0592	DNA-directed DNA polymerase activity
BL12_RS00025	COG0187	DNA topoisomerase II activity
BL12_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BL12_RS00045	COG1272	protein, Hemolysin III
BL12_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BL12_RS00055	COG2814	Major facilitator Superfamily
BL12_RS00070	COG1970	mechanosensitive ion channel activity
BL12_RS00110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BL12_RS00115	COG2226	methyltransferase
BL12_RS00220	COG0583	DNA-binding transcription factor activity
BL12_RS00235	COG3231	kanamycin kinase activity
BL12_RS00275	COG0783	Belongs to the Dps family
BL12_RS00280	COG1253	flavin adenine dinucleotide binding
BL12_RS00285	COG0288	reversible hydration of carbon dioxide
BL12_RS00290	COG1609	Transcriptional regulator
BL12_RS00315	COG1609	Transcriptional regulator
BL12_RS00320	COG3534	alpha-L-arabinofuranosidase
BL12_RS00340	COG0656	L-ascorbic acid biosynthetic process
BL12_RS00345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BL12_RS00360	COG0180	Tryptophanyl-tRNA synthetase
BL12_RS00375	COG0058	SHG alpha-glucan phosphorylase activity
BL12_RS00405	COG3764	Sortase (surface protein transpeptidase)
BL12_RS00420	COG0515	serine threonine protein kinase
BL12_RS00425	COG0768	penicillin binding
BL12_RS00455	COG0697	spore germination
BL12_RS00470	COG2226	methyltransferase
BL12_RS00475	COG2261	transglycosylase associated protein
BL12_RS00480	COG2261	transglycosylase associated protein
BL12_RS00495	COG2217	Heavy metal translocating P-type atpase
BL12_RS00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BL12_RS00515	COG0343	queuine tRNA-ribosyltransferase activity
BL12_RS00540	COG2814	Major facilitator Superfamily
BL12_RS00555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BL12_RS00585	COG0667	Aldo Keto reductase
BL12_RS00620	COG1063	alcohol dehydrogenase
BL12_RS00625	COG0583	DNA-binding transcription factor activity
BL12_RS00635	COG0191	fructose-bisphosphate aldolase activity
BL12_RS00645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BL12_RS00695	COG2211	Major facilitator Superfamily
BL12_RS00705	COG4770	biotin carboxylase activity
BL12_RS00735	COG0477	Major facilitator Superfamily
BL12_RS00785	COG1132	(ABC) transporter
BL12_RS00790	COG0390	transport system, permease component
BL12_RS00795	COG1113	amino acid transport
BL12_RS00800	COG0577	efflux transmembrane transporter activity
BL12_RS00800	COG1136	(ABC) transporter
BL12_RS00810	COG1113	amino acid transport
BL12_RS00825	COG0577	efflux transmembrane transporter activity
BL12_RS00830	COG1136	(ABC) transporter
BL12_RS00830	COG0577	efflux transmembrane transporter activity
BL12_RS00835	COG1846	Transcriptional regulator
BL12_RS00855	COG0671	phosphoesterase, PA-phosphatase related
BL12_RS00860	COG0110	maltose O-acetyltransferase activity
BL12_RS00900	COG1129	ABC transporter
BL12_RS00935	COG1309	transcriptional regulator
BL12_RS00955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BL12_RS00965	COG0305	Participates in initiation and elongation during chromosome replication
BL12_RS00970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BL12_RS01005	COG0494	nUDIX hydrolase
BL12_RS01005	COG0406	alpha-ribazole phosphatase activity
BL12_RS01090	COG1260	myo-inositol-1-phosphate synthase
BL12_RS01100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BL12_RS01100	COG1754	DNA topoisomerase type I activity
BL12_RS01160	COG0406	alpha-ribazole phosphatase activity
BL12_RS01215	COG0446	pyridine nucleotide-disulphide oxidoreductase
BL12_RS01220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BL12_RS01270	COG0436	Aminotransferase
BL12_RS01285	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BL12_RS01285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BL12_RS01295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BL12_RS01310	COG0742	ribosomal rna small subunit methyltransferase
BL12_RS01325	COG1837	Belongs to the UPF0109 family
BL12_RS01360	COG0488	(ABC) transporter
BL12_RS01370	COG0440	acetolactate synthase activity
BL12_RS01410	COG0667	Aldo Keto reductase
BL12_RS01475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BL12_RS01495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BL12_RS01500	COG1530	ribonuclease E activity
BL12_RS01525	COG0436	Aminotransferase
BL12_RS01560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BL12_RS01560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BL12_RS01565	COG1268	BioY protein
BL12_RS01570	COG4770	biotin carboxylase activity
BL12_RS01575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BL12_RS01600	COG0039	L-malate dehydrogenase activity
BL12_RS01615	COG1704	LemA family
BL12_RS01625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BL12_RS01630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BL12_RS01650	COG0826	peptidase U32
BL12_RS01665	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BL12_RS01675	COG3579	cysteine-type endopeptidase activity
BL12_RS01680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BL12_RS01685	COG2755	lipolytic protein G-D-S-L family
BL12_RS01685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BL12_RS01690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BL12_RS01695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BL12_RS01705	COG0745	RESPONSE REGULATOR receiver
BL12_RS01720	COG0581	inorganic phosphate transmembrane transporter activity
BL12_RS01730	COG2252	PERMEase
BL12_RS01815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BL12_RS01820	COG0531	amino acid
BL12_RS01835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BL12_RS01845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BL12_RS01850	COG1739	Uncharacterized protein family UPF0029
BL12_RS01885	COG1012	belongs to the aldehyde dehydrogenase family
BL12_RS01885	COG1454	alcohol dehydrogenase
BL12_RS01945	COG0255	Belongs to the universal ribosomal protein uL29 family
BL12_RS02075	COG0196	riboflavin kinase activity
BL12_RS02095	COG0328	RNA-DNA hybrid ribonuclease activity
BL12_RS02110	COG1803	Methylglyoxal synthase
BL12_RS02110	COG1597	lipid kinase activity
BL12_RS02135	COG2197	response regulator
BL12_RS02155	COG0626	cystathionine gamma-synthase activity
BL12_RS02165	COG2873	o-acetylhomoserine
BL12_RS02175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BL12_RS02190	COG3579	cysteine-type endopeptidase activity
BL12_RS02195	COG0531	amino acid
BL12_RS02205	COG1113	amino acid transport
BL12_RS02220	COG4716	Myosin-crossreactive antigen
BL12_RS02225	COG1063	alcohol dehydrogenase
BL12_RS02230	COG3321	synthase
BL12_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
BL12_RS02230	COG0604	alcohol dehydrogenase
BL12_RS02240	COG5002	protein histidine kinase activity
BL12_RS02245	COG0704	Plays a role in the regulation of phosphate uptake
BL12_RS02250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BL12_RS02255	COG1705	Flagellar rod assembly protein muramidase FlgJ
BL12_RS02255	COG3942	CHAP domain
BL12_RS02260	COG1388	LysM domain
BL12_RS02260	COG0791	NLP P60 protein
BL12_RS02280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BL12_RS02285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BL12_RS02290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BL12_RS02365	COG3189	MarR family transcriptional regulator
BL12_RS02375	COG3250	beta-galactosidase activity
BL12_RS02380	COG1609	Transcriptional regulator
BL12_RS02415	COG0395	ABC-type sugar transport system, permease component
BL12_RS02445	COG1216	Glycosyl transferase, family 2
BL12_RS02450	COG0628	permease
BL12_RS02485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BL12_RS02500	COG1946	Acyl-CoA thioesterase
BL12_RS02510	COG0242	peptide deformylase activity
BL12_RS02515	COG2873	o-acetylhomoserine
BL12_RS02550	COG3507	Belongs to the glycosyl hydrolase 43 family
BL12_RS02565	COG1175	transmembrane transport
BL12_RS02575	COG3507	Belongs to the glycosyl hydrolase 43 family
BL12_RS02585	COG2272	Belongs to the type-B carboxylesterase lipase family
BL12_RS02595	COG1070	Carbohydrate kinase
BL12_RS02600	COG1940	carbohydrate kinase activity
BL12_RS02620	COG0009	L-threonylcarbamoyladenylate synthase
BL12_RS02640	COG0561	phosphatase activity
BL12_RS02645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BL12_RS02665	COG3590	peptidase
BL12_RS02675	COG0024	Methionine aminopeptidase
BL12_RS02680	COG0372	Belongs to the citrate synthase family
BL12_RS02695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BL12_RS02700	COG2884	Cell division ATP-binding protein ftsE
BL12_RS02710	COG3942	CHAP domain
BL12_RS02710	COG1388	LysM domain
BL12_RS02730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL12_RS02735	COG0765	amino acid transport
BL12_RS02750	COG2205	protein histidine kinase activity
BL12_RS02750	COG0784	Response regulator, receiver
BL12_RS02750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL12_RS02750	COG2198	Histidine kinase
BL12_RS02755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BL12_RS02775	COG0747	negative chemotaxis
BL12_RS02780	COG0601	transmembrane transport
BL12_RS02785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BL12_RS02795	COG4172	Belongs to the ABC transporter superfamily
BL12_RS02810	COG0514	ATP-dependent DNA helicase (RecQ)
BL12_RS02890	COG0371	Dehydrogenase
BL12_RS02905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BL12_RS02910	COG0358	DNA primase activity
BL12_RS02915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BL12_RS02925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BL12_RS02930	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BL12_RS02935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BL12_RS02940	COG0735	belongs to the Fur family
BL12_RS02945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BL12_RS02950	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BL12_RS02955	COG0151	Belongs to the GarS family
BL12_RS02970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BL12_RS03025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BL12_RS03105	COG0284	orotidine-5'-phosphate decarboxylase activity
BL12_RS03130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BL12_RS03145	COG0560	Phosphoserine phosphatase
BL12_RS03150	COG0586	Pfam SNARE associated Golgi protein
BL12_RS03160	COG4122	O-methyltransferase activity
BL12_RS03190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BL12_RS03230	COG0714	Associated with various cellular activities
BL12_RS03245	COG1278	Cold shock
BL12_RS03265	COG0745	RESPONSE REGULATOR receiver
BL12_RS03270	COG2205	protein histidine kinase activity
BL12_RS03275	COG1278	Cold shock
BL12_RS03310	COG1196	nuclear chromosome segregation
BL12_RS03320	COG1126	abc transporter atp-binding protein
BL12_RS03325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL12_RS03330	COG0765	amino acid transport
BL12_RS03335	COG0765	amino acid transport
BL12_RS03340	COG2326	polyphosphate kinase activity
BL12_RS03355	COG2814	Major facilitator Superfamily
BL12_RS03360	COG1022	Amp-dependent synthetase and ligase
BL12_RS03365	COG3328	transposase activity
BL12_RS03390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BL12_RS03400	COG0656	L-ascorbic acid biosynthetic process
BL12_RS03425	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BL12_RS03445	COG0489	protein tyrosine kinase activity
BL12_RS03445	COG2151	metal-sulfur cluster biosynthetic enzyme
BL12_RS03450	COG4721	ABC-type cobalt transport system, permease component
BL12_RS03475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BL12_RS03500	COG1136	(ABC) transporter
BL12_RS03505	COG4721	ABC-type cobalt transport system, permease component
BL12_RS03510	COG4172	Belongs to the ABC transporter superfamily
BL12_RS03515	COG1136	(ABC) transporter
BL12_RS03520	COG0577	efflux transmembrane transporter activity
BL12_RS03530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BL12_RS03620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BL12_RS03625	COG0569	domain protein
BL12_RS03640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BL12_RS03660	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BL12_RS03680	COG0799	negative regulation of ribosome biogenesis
BL12_RS03710	COG0406	alpha-ribazole phosphatase activity
BL12_RS03715	COG0598	Magnesium transport protein CorA
BL12_RS03745	COG0802	atpase or kinase
BL12_RS03800	COG0516	GMP reductase activity
BL12_RS03810	COG1022	Amp-dependent synthetase and ligase
BL12_RS03840	COG0575	Belongs to the CDS family
BL12_RS03880	COG1573	uracil-dna glycosylase
BL12_RS03890	COG0133	tryptophan synthase activity
BL12_RS03905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BL12_RS03920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BL12_RS03940	COG1716	ATPase activity
BL12_RS03955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BL12_RS03960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BL12_RS04010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BL12_RS04030	COG0045	succinate-CoA ligase (ADP-forming) activity
BL12_RS04065	COG0438	transferase activity, transferring glycosyl groups
BL12_RS04070	COG1560	Kdo2-lipid A biosynthetic process
BL12_RS04085	COG0488	(ABC) transporter
BL12_RS04095	COG0456	acetyltransferase
BL12_RS04165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BL12_RS04175	COG0436	Aminotransferase
BL12_RS04185	COG0436	Aminotransferase
BL12_RS04190	COG0561	phosphatase activity
BL12_RS04195	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BL12_RS04220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BL12_RS04255	COG0488	(ABC) transporter
BL12_RS04280	COG0450	alkyl hydroperoxide reductase
BL12_RS04290	COG0583	DNA-binding transcription factor activity
BL12_RS04330	COG0167	dihydroorotate dehydrogenase activity
BL12_RS04340	COG0284	orotidine-5'-phosphate decarboxylase activity
BL12_RS04345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BL12_RS04370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BL12_RS04390	COG1119	ATPase activity
BL12_RS04395	COG0297	glycogen (starch) synthase activity
BL12_RS04415	COG0067	glutamate synthase
BL12_RS04415	COG0070	glutamate synthase
BL12_RS04415	COG0069	glutamate synthase activity
BL12_RS04435	COG2860	membrane
BL12_RS04440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BL12_RS04465	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BL12_RS04490	COG1702	phosphate starvation-inducible protein PhoH
BL12_RS04495	COG0537	adenosine 5'-monophosphoramidase activity
BL12_RS04500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BL12_RS04525	COG2151	metal-sulfur cluster biosynthetic enzyme
BL12_RS04530	COG0822	iron-sulfur transferase activity
BL12_RS04540	COG0396	ATPase activity
BL12_RS04545	COG0719	Fe-S assembly protein
BL12_RS04555	COG1376	ErfK ybiS ycfS ynhG family protein
BL12_RS04570	COG1523	belongs to the glycosyl hydrolase 13 family
BL12_RS04615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BL12_RS04660	COG0588	phosphoglycerate mutase activity
BL12_RS04665	COG1950	PFAM Membrane protein of
BL12_RS04700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BL12_RS04715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BL12_RS04730	COG1131	(ABC) transporter
BL12_RS04735	COG1725	Transcriptional regulator
BL12_RS04745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BL12_RS04770	COG0563	adenylate kinase activity
BL12_RS04785	COG3039	Transposase
BL12_RS04805	COG0857	belongs to the CobB CobQ family
BL12_RS04805	COG0280	phosphate acetyltransferase
BL12_RS04810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BL12_RS04840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BL12_RS04855	COG0494	nUDIX hydrolase
BL12_RS04865	COG0469	pyruvate kinase activity
BL12_RS04880	COG0237	dephospho-CoA kinase activity
BL12_RS04885	COG0539	negative regulation of cytoplasmic translation
BL12_RS04895	COG0803	Belongs to the bacterial solute-binding protein 9 family
BL12_RS04900	COG1121	(ABC) transporter
BL12_RS04915	COG1329	Transcriptional regulator
BL12_RS04925	COG0745	RESPONSE REGULATOR receiver
BL12_RS04930	COG2205	protein histidine kinase activity
BL12_RS04960	COG1316	TRANSCRIPTIONal
BL12_RS04965	COG1316	TRANSCRIPTIONal
BL12_RS04990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BL12_RS05000	COG1760	l-serine dehydratase
BL12_RS05045	COG1116	anion transmembrane transporter activity
BL12_RS05070	COG1472	Belongs to the glycosyl hydrolase 3 family
BL12_RS05080	COG1966	Carbon starvation protein
BL12_RS05085	COG1132	(ABC) transporter
BL12_RS05090	COG1132	(ABC) transporter
BL12_RS05125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BL12_RS05125	COG1918	ferrous iron import across plasma membrane
BL12_RS05145	COG0363	glucosamine-6-phosphate deaminase activity
BL12_RS05150	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BL12_RS05155	COG3340	Belongs to the peptidase S51 family
BL12_RS05160	COG1114	Component of the transport system for branched-chain amino acids
BL12_RS05190	COG2233	PERMEase
BL12_RS05210	COG0012	GTP binding
BL12_RS05215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BL12_RS05225	COG4585	Histidine kinase
BL12_RS05230	COG2197	response regulator
BL12_RS05240	COG1136	(ABC) transporter
BL12_RS05240	COG0577	efflux transmembrane transporter activity
BL12_RS05250	COG1122	ATPase activity
BL12_RS05255	COG2873	o-acetylhomoserine
BL12_RS05285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BL12_RS05350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BL12_RS05355	COG1882	Formate acetyltransferase
BL12_RS05370	COG1473	amidohydrolase
BL12_RS05375	COG2011	ABC-type metal ion transport system permease component
BL12_RS05385	COG1464	Belongs to the NlpA lipoprotein family
BL12_RS05390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BL12_RS05395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BL12_RS05420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BL12_RS05425	COG4975	Glucose uptake
BL12_RS05430	COG1201	RNA secondary structure unwinding
BL12_RS05455	COG0187	DNA topoisomerase II activity
BL12_RS05460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BL12_RS05470	COG0142	geranyltranstransferase activity
BL12_RS05490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BL12_RS05500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BL12_RS05520	COG1396	sequence-specific DNA binding
BL12_RS05530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BL12_RS05550	COG2357	RelA SpoT domain protein
BL12_RS05555	COG0670	Belongs to the BI1 family
BL12_RS05560	COG3804	dihydrodipicolinate reductase
BL12_RS05575	COG1131	(ABC) transporter
BL12_RS05580	COG4585	Histidine kinase
BL12_RS05585	COG2197	response regulator
BL12_RS05605	COG0110	maltose O-acetyltransferase activity
BL12_RS05615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BL12_RS05645	COG0708	Exodeoxyribonuclease III
BL12_RS05660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BL12_RS05665	COG0601	transmembrane transport
BL12_RS05670	COG4166	transmembrane transport
BL12_RS05680	COG1136	(ABC) transporter
BL12_RS05685	COG0577	efflux transmembrane transporter activity
BL12_RS05695	COG0287	Prephenate dehydrogenase
BL12_RS05710	COG1217	gtp-binding protein TYPA
BL12_RS05715	COG0477	Major facilitator Superfamily
BL12_RS05745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BL12_RS05760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BL12_RS05770	COG2017	converts alpha-aldose to the beta-anomer
BL12_RS05795	COG0285	dihydrofolate synthase activity
BL12_RS05815	COG0006	proline dipeptidase activity
BL12_RS05820	COG2816	NAD+ diphosphatase activity
BL12_RS05840	COG0582	viral genome integration into host DNA
BL12_RS05920	COG0601	transmembrane transport
BL12_RS05965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BL12_RS05975	COG0768	penicillin binding
BL12_RS06000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BL12_RS06020	COG1230	cation diffusion facilitator family transporter
BL12_RS06030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BL12_RS06040	COG1643	Atp-dependent helicase
BL12_RS06085	COG0587	DNA-directed DNA polymerase activity
BL12_RS06120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BL12_RS06125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BL12_RS06165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BL12_RS06170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BL12_RS06175	COG1957	nucleoside hydrolase
BL12_RS06230	COG3480	Lon protease (S16) C-terminal proteolytic domain
BL12_RS06255	COG0613	PHP domain protein
BL12_RS06265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BL12_RS06290	COG1126	abc transporter atp-binding protein
BL12_RS06295	COG0765	amino acid transport
BL12_RS06300	COG0765	amino acid transport
BL12_RS06305	COG0436	Aminotransferase
BL12_RS06310	COG2011	ABC-type metal ion transport system permease component
BL12_RS06320	COG1464	Belongs to the NlpA lipoprotein family
BL12_RS06325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BL12_RS06385	COG4166	transmembrane transport
BL12_RS06390	COG2814	Major facilitator Superfamily
BL12_RS06395	COG1842	Phage shock protein A
BL12_RS06415	COG2365	Tyrosine phosphatase family
BL12_RS06430	COG1132	(ABC) transporter
BL12_RS06435	COG1132	(ABC) transporter
BL12_RS06480	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BL12_RS06485	COG1468	defense response to virus
BL12_RS06485	COG1518	maintenance of DNA repeat elements
BL12_RS06520	COG1328	CTP reductase activity
BL12_RS06520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BL12_RS06525	COG1570	exodeoxyribonuclease VII activity
BL12_RS06530	COG1722	exodeoxyribonuclease VII activity
BL12_RS06550	COG0436	Aminotransferase
BL12_RS06585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BL12_RS06610	COG0210	DNA helicase
BL12_RS06630	COG0714	Associated with various cellular activities
BL12_RS06670	COG1194	a g-specific adenine glycosylase
BL12_RS06675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BL12_RS06695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BL12_RS06705	COG1349	DNA-binding transcription factor activity
BL12_RS06710	COG1216	Glycosyl transferase, family 2
BL12_RS06715	COG0167	dihydroorotate dehydrogenase activity
BL12_RS06720	COG1902	pentaerythritol trinitrate reductase activity
BL12_RS06725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BL12_RS06725	COG4499	WXG100 protein secretion system (Wss), protein YukC
BL12_RS06735	COG0095	Lipoate-protein ligase
BL12_RS06780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BL12_RS06815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BL12_RS06825	COG1088	dTDP-glucose 4,6-dehydratase activity
BL12_RS06845	COG1442	glycosyl transferase family 8
BL12_RS06845	COG1216	Glycosyl transferase, family 2
BL12_RS06895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BL12_RS06905	COG2814	Major facilitator Superfamily
BL12_RS06960	COG4988	ABC transporter
BL12_RS06975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BL12_RS06985	COG0489	protein tyrosine kinase activity
BL12_RS07005	COG0083	homoserine kinase activity
BL12_RS07010	COG0460	homoserine dehydrogenase
BL12_RS07015	COG0019	diaminopimelate decarboxylase activity
BL12_RS07030	COG0251	oxidation-reduction process
BL12_RS07035	COG0395	ABC-type sugar transport system, permease component
BL12_RS07040	COG3459	Glycosyltransferase 36 associated
BL12_RS07065	COG0545	Peptidyl-prolyl cis-trans isomerase
BL12_RS07075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BL12_RS07110	COG0356	it plays a direct role in the translocation of protons across the membrane
BL12_RS07120	COG0477	Major facilitator Superfamily
BL12_RS07175	COG0582	viral genome integration into host DNA
BL12_RS07190	COG0679	Auxin Efflux Carrier
BL12_RS07195	COG0028	Belongs to the TPP enzyme family
BL12_RS07220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BL12_RS07230	COG0745	RESPONSE REGULATOR receiver
BL12_RS07240	COG0747	negative chemotaxis
BL12_RS07255	COG0287	Prephenate dehydrogenase
BL12_RS07255	COG1605	Chorismate mutase
BL12_RS07320	COG2217	Heavy metal translocating P-type atpase
BL12_RS07330	COG0179	Fumarylacetoacetate (FAA) hydrolase
BL12_RS07355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BL12_RS07370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BL12_RS07420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BL12_RS07435	COG1609	Transcriptional regulator
BL12_RS07470	COG1368	sulfuric ester hydrolase activity
BL12_RS07475	COG1368	sulfuric ester hydrolase activity
BL12_RS07480	COG1216	Glycosyl transferase, family 2
BL12_RS07530	COG1216	Glycosyl transferase, family 2
BL12_RS07580	COG0084	hydrolase, TatD family'
BL12_RS07595	COG1132	(ABC) transporter
BL12_RS07600	COG1132	(ABC) transporter
BL12_RS07635	COG0586	Pfam SNARE associated Golgi protein
BL12_RS07655	COG1309	transcriptional regulator
BL12_RS07660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BL12_RS07665	COG0789	Transcriptional regulator
BL12_RS07670	COG0484	heat shock protein binding
BL12_RS07700	COG1523	belongs to the glycosyl hydrolase 13 family
BL12_RS07705	COG3833	ABC-type maltose transport systems, permease component
BL12_RS07710	COG1175	transmembrane transport
BL12_RS07720	COG0366	Alpha amylase catalytic
BL12_RS07745	COG1609	Transcriptional regulator
BL12_RS07755	COG0366	Alpha amylase catalytic
BL12_RS07770	COG0778	Nitroreductase
BL12_RS07780	COG2814	Major facilitator Superfamily
BL12_RS07840	COG1609	Transcriptional regulator
BL12_RS07845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BL12_RS07850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BL12_RS07855	COG0366	Alpha amylase catalytic
BL12_RS07870	COG0395	ABC-type sugar transport system, permease component
BL12_RS07875	COG1175	transmembrane transport
BL12_RS07895	COG0590	tRNA wobble adenosine to inosine editing
BL12_RS07895	COG0037	tRNA processing
BL12_RS07900	COG0025	NhaP-type Na H and K H
BL12_RS07920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BL12_RS07925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BL12_RS07935	COG3842	ATPase activity
BL12_RS07940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BL12_RS07960	COG3583	domain protein
BL12_RS07980	COG0617	tRNA 3'-terminal CCA addition
BL12_RS08000	COG0492	ferredoxin-NADP+ reductase activity
BL12_RS08005	COG1475	DNA binding
BL12_RS08010	COG1192	Involved in chromosome partitioning
BL12_RS08020	COG1847	R3H domain protein