locus-tag	class	description
NC88_RS00010	COG0592	DNA-directed DNA polymerase activity
NC88_RS00025	COG0187	DNA topoisomerase II activity
NC88_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NC88_RS00045	COG1272	protein, Hemolysin III
NC88_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NC88_RS00055	COG2814	Major facilitator Superfamily
NC88_RS00070	COG1970	mechanosensitive ion channel activity
NC88_RS00110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NC88_RS00115	COG2226	methyltransferase
NC88_RS00220	COG0583	DNA-binding transcription factor activity
NC88_RS00235	COG3231	kanamycin kinase activity
NC88_RS00275	COG0783	Belongs to the Dps family
NC88_RS00280	COG1253	flavin adenine dinucleotide binding
NC88_RS00285	COG0288	reversible hydration of carbon dioxide
NC88_RS00290	COG1609	Transcriptional regulator
NC88_RS00310	COG1609	Transcriptional regulator
NC88_RS00315	COG3534	alpha-L-arabinofuranosidase
NC88_RS00335	COG0656	L-ascorbic acid biosynthetic process
NC88_RS00340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NC88_RS00355	COG0180	Tryptophanyl-tRNA synthetase
NC88_RS00370	COG0058	SHG alpha-glucan phosphorylase activity
NC88_RS00400	COG3764	Sortase (surface protein transpeptidase)
NC88_RS00415	COG0515	serine threonine protein kinase
NC88_RS00420	COG0768	penicillin binding
NC88_RS00450	COG0697	spore germination
NC88_RS00465	COG2226	methyltransferase
NC88_RS00470	COG2261	transglycosylase associated protein
NC88_RS00475	COG2261	transglycosylase associated protein
NC88_RS00490	COG2217	Heavy metal translocating P-type atpase
NC88_RS00495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NC88_RS00510	COG0343	queuine tRNA-ribosyltransferase activity
NC88_RS00535	COG2814	Major facilitator Superfamily
NC88_RS00550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NC88_RS00580	COG0667	Aldo Keto reductase
NC88_RS00615	COG1063	alcohol dehydrogenase
NC88_RS00620	COG0583	DNA-binding transcription factor activity
NC88_RS00630	COG0191	fructose-bisphosphate aldolase activity
NC88_RS00640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NC88_RS00685	COG2211	Major facilitator Superfamily
NC88_RS00695	COG4770	biotin carboxylase activity
NC88_RS00730	COG0477	Major facilitator Superfamily
NC88_RS00785	COG1132	(ABC) transporter
NC88_RS00790	COG0390	transport system, permease component
NC88_RS00795	COG1113	amino acid transport
NC88_RS00800	COG1136	(ABC) transporter
NC88_RS00800	COG0577	efflux transmembrane transporter activity
NC88_RS00810	COG1113	amino acid transport
NC88_RS00825	COG0577	efflux transmembrane transporter activity
NC88_RS00830	COG1136	(ABC) transporter
NC88_RS00830	COG0577	efflux transmembrane transporter activity
NC88_RS00835	COG1846	Transcriptional regulator
NC88_RS00855	COG0671	phosphoesterase, PA-phosphatase related
NC88_RS00860	COG0110	maltose O-acetyltransferase activity
NC88_RS00900	COG1129	ABC transporter
NC88_RS00935	COG1309	transcriptional regulator
NC88_RS00955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NC88_RS00965	COG0305	Participates in initiation and elongation during chromosome replication
NC88_RS00970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NC88_RS01005	COG0406	alpha-ribazole phosphatase activity
NC88_RS01005	COG0494	nUDIX hydrolase
NC88_RS01090	COG1260	myo-inositol-1-phosphate synthase
NC88_RS01105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NC88_RS01105	COG1754	DNA topoisomerase type I activity
NC88_RS01165	COG0406	alpha-ribazole phosphatase activity
NC88_RS01220	COG0446	pyridine nucleotide-disulphide oxidoreductase
NC88_RS01225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NC88_RS01275	COG0436	Aminotransferase
NC88_RS01290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NC88_RS01290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NC88_RS01300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NC88_RS01315	COG0742	ribosomal rna small subunit methyltransferase
NC88_RS01330	COG1837	Belongs to the UPF0109 family
NC88_RS01365	COG0488	(ABC) transporter
NC88_RS01375	COG0440	acetolactate synthase activity
NC88_RS01415	COG0667	Aldo Keto reductase
NC88_RS01480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NC88_RS01500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NC88_RS01505	COG1530	ribonuclease E activity
NC88_RS01530	COG0436	Aminotransferase
NC88_RS01565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NC88_RS01565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NC88_RS01570	COG1268	BioY protein
NC88_RS01575	COG4770	biotin carboxylase activity
NC88_RS01580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NC88_RS01605	COG0039	L-malate dehydrogenase activity
NC88_RS01620	COG1704	LemA family
NC88_RS01630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NC88_RS01635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NC88_RS01655	COG0826	peptidase U32
NC88_RS01670	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NC88_RS01680	COG3579	cysteine-type endopeptidase activity
NC88_RS01685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NC88_RS01690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NC88_RS01690	COG2755	lipolytic protein G-D-S-L family
NC88_RS01695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NC88_RS01700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NC88_RS01710	COG0745	RESPONSE REGULATOR receiver
NC88_RS01725	COG0581	inorganic phosphate transmembrane transporter activity
NC88_RS01735	COG2252	PERMEase
NC88_RS01820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NC88_RS01825	COG0531	amino acid
NC88_RS01840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NC88_RS01850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NC88_RS01855	COG1739	Uncharacterized protein family UPF0029
NC88_RS01890	COG1454	alcohol dehydrogenase
NC88_RS01890	COG1012	belongs to the aldehyde dehydrogenase family
NC88_RS01950	COG0255	Belongs to the universal ribosomal protein uL29 family
NC88_RS02085	COG0196	riboflavin kinase activity
NC88_RS02110	COG0328	RNA-DNA hybrid ribonuclease activity
NC88_RS02125	COG1803	Methylglyoxal synthase
NC88_RS02125	COG1597	lipid kinase activity
NC88_RS02150	COG2197	response regulator
NC88_RS02170	COG0626	cystathionine gamma-synthase activity
NC88_RS02180	COG2873	o-acetylhomoserine
NC88_RS02190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NC88_RS02205	COG3579	cysteine-type endopeptidase activity
NC88_RS02210	COG0531	amino acid
NC88_RS02220	COG1113	amino acid transport
NC88_RS02235	COG4716	Myosin-crossreactive antigen
NC88_RS02240	COG1063	alcohol dehydrogenase
NC88_RS02245	COG3321	synthase
NC88_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
NC88_RS02245	COG0604	alcohol dehydrogenase
NC88_RS02260	COG5002	protein histidine kinase activity
NC88_RS02265	COG0704	Plays a role in the regulation of phosphate uptake
NC88_RS02270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NC88_RS02275	COG3942	CHAP domain
NC88_RS02275	COG1705	Flagellar rod assembly protein muramidase FlgJ
NC88_RS02280	COG0791	NLP P60 protein
NC88_RS02280	COG1388	LysM domain
NC88_RS02300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NC88_RS02305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NC88_RS02310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NC88_RS02380	COG3189	MarR family transcriptional regulator
NC88_RS02390	COG3250	beta-galactosidase activity
NC88_RS02395	COG1609	Transcriptional regulator
NC88_RS02430	COG0395	ABC-type sugar transport system, permease component
NC88_RS02460	COG1216	Glycosyl transferase, family 2
NC88_RS02465	COG0628	permease
NC88_RS02500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NC88_RS02515	COG1946	Acyl-CoA thioesterase
NC88_RS02525	COG0242	peptide deformylase activity
NC88_RS02530	COG2873	o-acetylhomoserine
NC88_RS02565	COG3507	Belongs to the glycosyl hydrolase 43 family
NC88_RS02580	COG1175	transmembrane transport
NC88_RS02590	COG3507	Belongs to the glycosyl hydrolase 43 family
NC88_RS02600	COG2272	Belongs to the type-B carboxylesterase lipase family
NC88_RS02610	COG1070	Carbohydrate kinase
NC88_RS02615	COG1940	carbohydrate kinase activity
NC88_RS02635	COG0009	L-threonylcarbamoyladenylate synthase
NC88_RS02655	COG0561	phosphatase activity
NC88_RS02660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NC88_RS02680	COG3590	peptidase
NC88_RS02690	COG0024	Methionine aminopeptidase
NC88_RS02695	COG0372	Belongs to the citrate synthase family
NC88_RS02710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NC88_RS02715	COG2884	Cell division ATP-binding protein ftsE
NC88_RS02725	COG1388	LysM domain
NC88_RS02725	COG3942	CHAP domain
NC88_RS02740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC88_RS02745	COG0765	amino acid transport
NC88_RS02760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC88_RS02760	COG2198	Histidine kinase
NC88_RS02760	COG2205	protein histidine kinase activity
NC88_RS02760	COG0784	Response regulator, receiver
NC88_RS02765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NC88_RS02785	COG0747	negative chemotaxis
NC88_RS02790	COG0601	transmembrane transport
NC88_RS02795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC88_RS02805	COG4172	Belongs to the ABC transporter superfamily
NC88_RS02820	COG0514	ATP-dependent DNA helicase (RecQ)
NC88_RS02905	COG0371	Dehydrogenase
NC88_RS02920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NC88_RS02925	COG0358	DNA primase activity
NC88_RS02930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NC88_RS02940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NC88_RS02945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NC88_RS02950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NC88_RS02955	COG0735	belongs to the Fur family
NC88_RS02960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NC88_RS02965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NC88_RS02970	COG0151	Belongs to the GarS family
NC88_RS02985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NC88_RS03040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NC88_RS03120	COG0284	orotidine-5'-phosphate decarboxylase activity
NC88_RS03145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NC88_RS03160	COG0560	Phosphoserine phosphatase
NC88_RS03165	COG0586	Pfam SNARE associated Golgi protein
NC88_RS03175	COG4122	O-methyltransferase activity
NC88_RS03205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NC88_RS03245	COG0714	Associated with various cellular activities
NC88_RS03260	COG1278	Cold shock
NC88_RS03280	COG0745	RESPONSE REGULATOR receiver
NC88_RS03285	COG2205	protein histidine kinase activity
NC88_RS03290	COG1278	Cold shock
NC88_RS03325	COG1196	nuclear chromosome segregation
NC88_RS03335	COG1126	abc transporter atp-binding protein
NC88_RS03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NC88_RS03345	COG0765	amino acid transport
NC88_RS03350	COG0765	amino acid transport
NC88_RS03355	COG2326	polyphosphate kinase activity
NC88_RS03370	COG2814	Major facilitator Superfamily
NC88_RS03375	COG1022	Amp-dependent synthetase and ligase
NC88_RS03380	COG3328	transposase activity
NC88_RS03410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NC88_RS03420	COG0656	L-ascorbic acid biosynthetic process
NC88_RS03445	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NC88_RS03465	COG0489	protein tyrosine kinase activity
NC88_RS03465	COG2151	metal-sulfur cluster biosynthetic enzyme
NC88_RS03470	COG4721	ABC-type cobalt transport system, permease component
NC88_RS03495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NC88_RS03530	COG4721	ABC-type cobalt transport system, permease component
NC88_RS03535	COG4172	Belongs to the ABC transporter superfamily
NC88_RS03540	COG1136	(ABC) transporter
NC88_RS03545	COG0577	efflux transmembrane transporter activity
NC88_RS03555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NC88_RS03645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NC88_RS03650	COG0569	domain protein
NC88_RS03665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NC88_RS03685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NC88_RS03705	COG0799	negative regulation of ribosome biogenesis
NC88_RS03735	COG0406	alpha-ribazole phosphatase activity
NC88_RS03740	COG0598	Magnesium transport protein CorA
NC88_RS03770	COG0802	atpase or kinase
NC88_RS03825	COG0516	GMP reductase activity
NC88_RS03835	COG1022	Amp-dependent synthetase and ligase
NC88_RS03865	COG0575	Belongs to the CDS family
NC88_RS03905	COG1573	uracil-dna glycosylase
NC88_RS03920	COG0133	tryptophan synthase activity
NC88_RS03935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NC88_RS03950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NC88_RS03970	COG1716	ATPase activity
NC88_RS03985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NC88_RS03990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NC88_RS04040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NC88_RS04060	COG0045	succinate-CoA ligase (ADP-forming) activity
NC88_RS04095	COG0438	transferase activity, transferring glycosyl groups
NC88_RS04100	COG1560	Kdo2-lipid A biosynthetic process
NC88_RS04115	COG0488	(ABC) transporter
NC88_RS04125	COG0456	acetyltransferase
NC88_RS04190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NC88_RS04200	COG0436	Aminotransferase
NC88_RS04210	COG0436	Aminotransferase
NC88_RS04215	COG0561	phosphatase activity
NC88_RS04220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NC88_RS04245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NC88_RS04275	COG0488	(ABC) transporter
NC88_RS04300	COG0450	alkyl hydroperoxide reductase
NC88_RS04310	COG0583	DNA-binding transcription factor activity
NC88_RS04350	COG0167	dihydroorotate dehydrogenase activity
NC88_RS04360	COG0284	orotidine-5'-phosphate decarboxylase activity
NC88_RS04365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NC88_RS04410	COG1119	ATPase activity
NC88_RS04415	COG0297	glycogen (starch) synthase activity
NC88_RS04435	COG0070	glutamate synthase
NC88_RS04435	COG0069	glutamate synthase activity
NC88_RS04435	COG0067	glutamate synthase
NC88_RS04455	COG2860	membrane
NC88_RS04460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NC88_RS04485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NC88_RS04510	COG1702	phosphate starvation-inducible protein PhoH
NC88_RS04515	COG0537	adenosine 5'-monophosphoramidase activity
NC88_RS04520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NC88_RS04545	COG2151	metal-sulfur cluster biosynthetic enzyme
NC88_RS04550	COG0822	iron-sulfur transferase activity
NC88_RS04560	COG0396	ATPase activity
NC88_RS04565	COG0719	Fe-S assembly protein
NC88_RS04575	COG1376	ErfK ybiS ycfS ynhG family protein
NC88_RS04590	COG1523	belongs to the glycosyl hydrolase 13 family
NC88_RS04640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NC88_RS04685	COG0588	phosphoglycerate mutase activity
NC88_RS04690	COG1950	PFAM Membrane protein of
NC88_RS04725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NC88_RS04740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NC88_RS04755	COG1131	(ABC) transporter
NC88_RS04760	COG1725	Transcriptional regulator
NC88_RS04770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NC88_RS04795	COG0563	adenylate kinase activity
NC88_RS04810	COG3039	Transposase
NC88_RS04830	COG0857	belongs to the CobB CobQ family
NC88_RS04830	COG0280	phosphate acetyltransferase
NC88_RS04835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NC88_RS04865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NC88_RS04880	COG0494	nUDIX hydrolase
NC88_RS04890	COG0469	pyruvate kinase activity
NC88_RS04905	COG0237	dephospho-CoA kinase activity
NC88_RS04910	COG0539	negative regulation of cytoplasmic translation
NC88_RS04920	COG0803	Belongs to the bacterial solute-binding protein 9 family
NC88_RS04925	COG1121	(ABC) transporter
NC88_RS04940	COG1329	Transcriptional regulator
NC88_RS04950	COG0745	RESPONSE REGULATOR receiver
NC88_RS04955	COG2205	protein histidine kinase activity
NC88_RS04985	COG1316	TRANSCRIPTIONal
NC88_RS04990	COG1316	TRANSCRIPTIONal
NC88_RS05015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NC88_RS05025	COG1760	l-serine dehydratase
NC88_RS05070	COG1116	anion transmembrane transporter activity
NC88_RS05095	COG1472	Belongs to the glycosyl hydrolase 3 family
NC88_RS05105	COG1966	Carbon starvation protein
NC88_RS05145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NC88_RS05145	COG1918	ferrous iron import across plasma membrane
NC88_RS05165	COG0363	glucosamine-6-phosphate deaminase activity
NC88_RS05170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NC88_RS05175	COG3340	Belongs to the peptidase S51 family
NC88_RS05180	COG1114	Component of the transport system for branched-chain amino acids
NC88_RS05210	COG2233	PERMEase
NC88_RS05230	COG0012	GTP binding
NC88_RS05235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NC88_RS05245	COG4585	Histidine kinase
NC88_RS05250	COG2197	response regulator
NC88_RS05260	COG1136	(ABC) transporter
NC88_RS05260	COG0577	efflux transmembrane transporter activity
NC88_RS05270	COG1122	ATPase activity
NC88_RS05275	COG2873	o-acetylhomoserine
NC88_RS05305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NC88_RS05370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NC88_RS05375	COG1882	Formate acetyltransferase
NC88_RS05390	COG1473	amidohydrolase
NC88_RS05395	COG2011	ABC-type metal ion transport system permease component
NC88_RS05405	COG1464	Belongs to the NlpA lipoprotein family
NC88_RS05410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NC88_RS05415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NC88_RS05440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NC88_RS05445	COG4975	Glucose uptake
NC88_RS05450	COG1201	RNA secondary structure unwinding
NC88_RS05475	COG0187	DNA topoisomerase II activity
NC88_RS05480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NC88_RS05490	COG0142	geranyltranstransferase activity
NC88_RS05510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NC88_RS05520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NC88_RS05545	COG1396	sequence-specific DNA binding
NC88_RS05555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NC88_RS05575	COG2357	RelA SpoT domain protein
NC88_RS05580	COG0670	Belongs to the BI1 family
NC88_RS05585	COG3804	dihydrodipicolinate reductase
NC88_RS05600	COG1131	(ABC) transporter
NC88_RS05605	COG4585	Histidine kinase
NC88_RS05610	COG2197	response regulator
NC88_RS05625	COG0366	Alpha amylase catalytic
NC88_RS05630	COG2182	Extracellular solute-binding protein
NC88_RS05645	COG0110	maltose O-acetyltransferase activity
NC88_RS05655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NC88_RS05685	COG0708	Exodeoxyribonuclease III
NC88_RS05700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NC88_RS05705	COG0601	transmembrane transport
NC88_RS05710	COG4166	transmembrane transport
NC88_RS05720	COG1136	(ABC) transporter
NC88_RS05725	COG0577	efflux transmembrane transporter activity
NC88_RS05735	COG0287	Prephenate dehydrogenase
NC88_RS05750	COG1217	gtp-binding protein TYPA
NC88_RS05755	COG0477	Major facilitator Superfamily
NC88_RS05785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NC88_RS05800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NC88_RS05810	COG2017	converts alpha-aldose to the beta-anomer
NC88_RS05835	COG0285	dihydrofolate synthase activity
NC88_RS05855	COG0006	proline dipeptidase activity
NC88_RS05860	COG2816	NAD+ diphosphatase activity
NC88_RS05880	COG0582	viral genome integration into host DNA
NC88_RS05965	COG0601	transmembrane transport
NC88_RS06005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NC88_RS06015	COG0768	penicillin binding
NC88_RS06040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NC88_RS06060	COG1230	cation diffusion facilitator family transporter
NC88_RS06070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NC88_RS06080	COG1643	Atp-dependent helicase
NC88_RS06125	COG0587	DNA-directed DNA polymerase activity
NC88_RS06160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NC88_RS06205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NC88_RS06210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NC88_RS06215	COG1957	nucleoside hydrolase
NC88_RS06270	COG3480	Lon protease (S16) C-terminal proteolytic domain
NC88_RS06295	COG0613	PHP domain protein
NC88_RS06305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NC88_RS06330	COG1126	abc transporter atp-binding protein
NC88_RS06335	COG0765	amino acid transport
NC88_RS06340	COG0765	amino acid transport
NC88_RS06345	COG0436	Aminotransferase
NC88_RS06350	COG2011	ABC-type metal ion transport system permease component
NC88_RS06360	COG1464	Belongs to the NlpA lipoprotein family
NC88_RS06365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NC88_RS06425	COG4166	transmembrane transport
NC88_RS06430	COG2814	Major facilitator Superfamily
NC88_RS06435	COG1842	Phage shock protein A
NC88_RS06455	COG2365	Tyrosine phosphatase family
NC88_RS06470	COG1132	(ABC) transporter
NC88_RS06475	COG1132	(ABC) transporter
NC88_RS06525	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NC88_RS06530	COG1518	maintenance of DNA repeat elements
NC88_RS06530	COG1468	defense response to virus
NC88_RS06565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NC88_RS06565	COG1328	CTP reductase activity
NC88_RS06570	COG1570	exodeoxyribonuclease VII activity
NC88_RS06575	COG1722	exodeoxyribonuclease VII activity
NC88_RS06595	COG0436	Aminotransferase
NC88_RS06630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NC88_RS06655	COG0210	DNA helicase
NC88_RS06675	COG0714	Associated with various cellular activities
NC88_RS06715	COG1194	a g-specific adenine glycosylase
NC88_RS06720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NC88_RS06740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NC88_RS06750	COG1349	DNA-binding transcription factor activity
NC88_RS06755	COG1216	Glycosyl transferase, family 2
NC88_RS06760	COG0167	dihydroorotate dehydrogenase activity
NC88_RS06765	COG1902	pentaerythritol trinitrate reductase activity
NC88_RS06770	COG4499	WXG100 protein secretion system (Wss), protein YukC
NC88_RS06770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NC88_RS06780	COG0095	Lipoate-protein ligase
NC88_RS06825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NC88_RS06860	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NC88_RS06870	COG1088	dTDP-glucose 4,6-dehydratase activity
NC88_RS06890	COG1442	glycosyl transferase family 8
NC88_RS06890	COG1216	Glycosyl transferase, family 2
NC88_RS06940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NC88_RS06950	COG2814	Major facilitator Superfamily
NC88_RS07005	COG4988	ABC transporter
NC88_RS07020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NC88_RS07030	COG0489	protein tyrosine kinase activity
NC88_RS07045	COG0083	homoserine kinase activity
NC88_RS07050	COG0460	homoserine dehydrogenase
NC88_RS07055	COG0019	diaminopimelate decarboxylase activity
NC88_RS07070	COG0251	oxidation-reduction process
NC88_RS07075	COG0395	ABC-type sugar transport system, permease component
NC88_RS07080	COG3459	Glycosyltransferase 36 associated
NC88_RS07105	COG0545	Peptidyl-prolyl cis-trans isomerase
NC88_RS07115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NC88_RS07150	COG0356	it plays a direct role in the translocation of protons across the membrane
NC88_RS07160	COG0477	Major facilitator Superfamily
NC88_RS07210	COG0582	viral genome integration into host DNA
NC88_RS07225	COG0679	Auxin Efflux Carrier
NC88_RS07230	COG0028	Belongs to the TPP enzyme family
NC88_RS07255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NC88_RS07265	COG0745	RESPONSE REGULATOR receiver
NC88_RS07275	COG0747	negative chemotaxis
NC88_RS07290	COG0287	Prephenate dehydrogenase
NC88_RS07290	COG1605	Chorismate mutase
NC88_RS07355	COG2217	Heavy metal translocating P-type atpase
NC88_RS07365	COG0179	Fumarylacetoacetate (FAA) hydrolase
NC88_RS07390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NC88_RS07405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NC88_RS07450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NC88_RS07465	COG1609	Transcriptional regulator
NC88_RS07500	COG1368	sulfuric ester hydrolase activity
NC88_RS07505	COG1368	sulfuric ester hydrolase activity
NC88_RS07510	COG1216	Glycosyl transferase, family 2
NC88_RS07560	COG1216	Glycosyl transferase, family 2
NC88_RS07615	COG0084	hydrolase, TatD family'
NC88_RS07630	COG1132	(ABC) transporter
NC88_RS07635	COG1132	(ABC) transporter
NC88_RS07670	COG0586	Pfam SNARE associated Golgi protein
NC88_RS07690	COG1309	transcriptional regulator
NC88_RS07695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NC88_RS07700	COG0789	Transcriptional regulator
NC88_RS07705	COG0484	heat shock protein binding
NC88_RS07735	COG1523	belongs to the glycosyl hydrolase 13 family
NC88_RS07740	COG3833	ABC-type maltose transport systems, permease component
NC88_RS07745	COG1175	transmembrane transport
NC88_RS07755	COG0366	Alpha amylase catalytic
NC88_RS07780	COG1609	Transcriptional regulator
NC88_RS07790	COG0366	Alpha amylase catalytic
NC88_RS07805	COG0778	Nitroreductase
NC88_RS07815	COG2814	Major facilitator Superfamily
NC88_RS07875	COG1609	Transcriptional regulator
NC88_RS07880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NC88_RS07885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NC88_RS07905	COG0395	ABC-type sugar transport system, permease component
NC88_RS07910	COG1175	transmembrane transport
NC88_RS07930	COG0590	tRNA wobble adenosine to inosine editing
NC88_RS07930	COG0037	tRNA processing
NC88_RS07935	COG0025	NhaP-type Na H and K H
NC88_RS07955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NC88_RS07960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NC88_RS07970	COG3842	ATPase activity
NC88_RS07975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NC88_RS07995	COG3583	domain protein
NC88_RS08015	COG0617	tRNA 3'-terminal CCA addition
NC88_RS08035	COG0492	ferredoxin-NADP+ reductase activity
NC88_RS08040	COG1475	DNA binding
NC88_RS08045	COG1192	Involved in chromosome partitioning
NC88_RS08055	COG1847	R3H domain protein