locus-tag	class	description
DU497_RS00010	COG0592	DNA-directed DNA polymerase activity
DU497_RS00025	COG0187	DNA topoisomerase II activity
DU497_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DU497_RS00045	COG1272	protein, Hemolysin III
DU497_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DU497_RS00055	COG2814	Major facilitator Superfamily
DU497_RS00070	COG1970	mechanosensitive ion channel activity
DU497_RS00115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DU497_RS00120	COG2226	methyltransferase
DU497_RS00225	COG0583	DNA-binding transcription factor activity
DU497_RS00240	COG3231	kanamycin kinase activity
DU497_RS00280	COG0783	Belongs to the Dps family
DU497_RS00285	COG1253	flavin adenine dinucleotide binding
DU497_RS00290	COG0288	reversible hydration of carbon dioxide
DU497_RS00295	COG1609	Transcriptional regulator
DU497_RS00315	COG1609	Transcriptional regulator
DU497_RS00320	COG3534	alpha-L-arabinofuranosidase
DU497_RS00340	COG0656	L-ascorbic acid biosynthetic process
DU497_RS00345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DU497_RS00360	COG0180	Tryptophanyl-tRNA synthetase
DU497_RS00375	COG0058	SHG alpha-glucan phosphorylase activity
DU497_RS00415	COG3764	Sortase (surface protein transpeptidase)
DU497_RS00430	COG0515	serine threonine protein kinase
DU497_RS00435	COG0768	penicillin binding
DU497_RS00470	COG0697	spore germination
DU497_RS00485	COG2226	methyltransferase
DU497_RS00495	COG2261	transglycosylase associated protein
DU497_RS00500	COG2261	transglycosylase associated protein
DU497_RS00525	COG2217	Heavy metal translocating P-type atpase
DU497_RS00530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DU497_RS00545	COG0343	queuine tRNA-ribosyltransferase activity
DU497_RS00570	COG2814	Major facilitator Superfamily
DU497_RS00585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DU497_RS00615	COG0667	Aldo Keto reductase
DU497_RS00655	COG1063	alcohol dehydrogenase
DU497_RS00660	COG0583	DNA-binding transcription factor activity
DU497_RS00670	COG0191	fructose-bisphosphate aldolase activity
DU497_RS00680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DU497_RS00730	COG2211	Major facilitator Superfamily
DU497_RS00770	COG0477	Major facilitator Superfamily
DU497_RS00830	COG1132	(ABC) transporter
DU497_RS00835	COG0390	transport system, permease component
DU497_RS00840	COG1113	amino acid transport
DU497_RS00845	COG1136	(ABC) transporter
DU497_RS00845	COG0577	efflux transmembrane transporter activity
DU497_RS00855	COG1113	amino acid transport
DU497_RS00870	COG0577	efflux transmembrane transporter activity
DU497_RS00875	COG1136	(ABC) transporter
DU497_RS00875	COG0577	efflux transmembrane transporter activity
DU497_RS00885	COG1846	Transcriptional regulator
DU497_RS00905	COG0671	phosphoesterase, PA-phosphatase related
DU497_RS00910	COG0110	maltose O-acetyltransferase activity
DU497_RS00955	COG1129	ABC transporter
DU497_RS00990	COG1309	transcriptional regulator
DU497_RS01010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DU497_RS01020	COG0305	Participates in initiation and elongation during chromosome replication
DU497_RS01025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DU497_RS01060	COG0406	alpha-ribazole phosphatase activity
DU497_RS01060	COG0494	nUDIX hydrolase
DU497_RS01155	COG1260	myo-inositol-1-phosphate synthase
DU497_RS01170	COG1754	DNA topoisomerase type I activity
DU497_RS01170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DU497_RS01235	COG0406	alpha-ribazole phosphatase activity
DU497_RS01300	COG0446	pyridine nucleotide-disulphide oxidoreductase
DU497_RS01310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DU497_RS01365	COG0436	Aminotransferase
DU497_RS01380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DU497_RS01380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DU497_RS01390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DU497_RS01405	COG0742	ribosomal rna small subunit methyltransferase
DU497_RS01420	COG1837	Belongs to the UPF0109 family
DU497_RS01460	COG0488	(ABC) transporter
DU497_RS01470	COG0440	acetolactate synthase activity
DU497_RS01510	COG0667	Aldo Keto reductase
DU497_RS01580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DU497_RS01600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DU497_RS01605	COG1530	ribonuclease E activity
DU497_RS01645	COG0436	Aminotransferase
DU497_RS01680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DU497_RS01680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DU497_RS01685	COG1268	BioY protein
DU497_RS01690	COG4770	biotin carboxylase activity
DU497_RS01695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DU497_RS01720	COG0039	L-malate dehydrogenase activity
DU497_RS01735	COG1704	LemA family
DU497_RS01745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DU497_RS01750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DU497_RS01770	COG0826	peptidase U32
DU497_RS01790	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DU497_RS01800	COG3579	cysteine-type endopeptidase activity
DU497_RS01805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DU497_RS01810	COG2755	lipolytic protein G-D-S-L family
DU497_RS01810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DU497_RS01815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DU497_RS01820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DU497_RS01830	COG0745	RESPONSE REGULATOR receiver
DU497_RS01845	COG0581	inorganic phosphate transmembrane transporter activity
DU497_RS01855	COG2252	PERMEase
DU497_RS01940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DU497_RS01945	COG0531	amino acid
DU497_RS01960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DU497_RS01970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DU497_RS01975	COG1739	Uncharacterized protein family UPF0029
DU497_RS02010	COG1012	belongs to the aldehyde dehydrogenase family
DU497_RS02010	COG1454	alcohol dehydrogenase
DU497_RS02070	COG0255	Belongs to the universal ribosomal protein uL29 family
DU497_RS02205	COG0196	riboflavin kinase activity
DU497_RS02230	COG0328	RNA-DNA hybrid ribonuclease activity
DU497_RS02250	COG1597	lipid kinase activity
DU497_RS02250	COG1803	Methylglyoxal synthase
DU497_RS02275	COG2197	response regulator
DU497_RS02295	COG0626	cystathionine gamma-synthase activity
DU497_RS02305	COG2873	o-acetylhomoserine
DU497_RS02315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DU497_RS02330	COG3579	cysteine-type endopeptidase activity
DU497_RS02335	COG0531	amino acid
DU497_RS02345	COG1113	amino acid transport
DU497_RS02360	COG4716	Myosin-crossreactive antigen
DU497_RS02365	COG1063	alcohol dehydrogenase
DU497_RS02370	COG1028	Short-chain dehydrogenase reductase Sdr
DU497_RS02370	COG0604	alcohol dehydrogenase
DU497_RS02370	COG3321	synthase
DU497_RS02380	COG5002	protein histidine kinase activity
DU497_RS02385	COG0704	Plays a role in the regulation of phosphate uptake
DU497_RS02390	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DU497_RS02395	COG3942	CHAP domain
DU497_RS02395	COG1705	Flagellar rod assembly protein muramidase FlgJ
DU497_RS02400	COG0791	NLP P60 protein
DU497_RS02400	COG1388	LysM domain
DU497_RS02420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DU497_RS02425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DU497_RS02430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DU497_RS02510	COG3189	MarR family transcriptional regulator
DU497_RS02520	COG3250	beta-galactosidase activity
DU497_RS02525	COG1609	Transcriptional regulator
DU497_RS02560	COG0395	ABC-type sugar transport system, permease component
DU497_RS02590	COG1216	Glycosyl transferase, family 2
DU497_RS02595	COG0628	permease
DU497_RS02630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DU497_RS02645	COG1946	Acyl-CoA thioesterase
DU497_RS02655	COG0242	peptide deformylase activity
DU497_RS02660	COG2873	o-acetylhomoserine
DU497_RS02695	COG3507	Belongs to the glycosyl hydrolase 43 family
DU497_RS02710	COG1175	transmembrane transport
DU497_RS02720	COG3507	Belongs to the glycosyl hydrolase 43 family
DU497_RS02730	COG2272	Belongs to the type-B carboxylesterase lipase family
DU497_RS02740	COG1070	Carbohydrate kinase
DU497_RS02745	COG1940	carbohydrate kinase activity
DU497_RS02765	COG0009	L-threonylcarbamoyladenylate synthase
DU497_RS02785	COG0561	phosphatase activity
DU497_RS02790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DU497_RS02810	COG3590	peptidase
DU497_RS02820	COG0024	Methionine aminopeptidase
DU497_RS02825	COG0372	Belongs to the citrate synthase family
DU497_RS02845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DU497_RS02850	COG2884	Cell division ATP-binding protein ftsE
DU497_RS02860	COG1388	LysM domain
DU497_RS02860	COG3942	CHAP domain
DU497_RS02880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DU497_RS02885	COG0765	amino acid transport
DU497_RS02900	COG2205	protein histidine kinase activity
DU497_RS02900	COG2198	Histidine kinase
DU497_RS02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DU497_RS02900	COG0784	Response regulator, receiver
DU497_RS02905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DU497_RS02925	COG0747	negative chemotaxis
DU497_RS02930	COG0601	transmembrane transport
DU497_RS02935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DU497_RS02945	COG4172	Belongs to the ABC transporter superfamily
DU497_RS02960	COG0514	ATP-dependent DNA helicase (RecQ)
DU497_RS03040	COG0371	Dehydrogenase
DU497_RS03055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DU497_RS03060	COG0358	DNA primase activity
DU497_RS03065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DU497_RS03075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DU497_RS03080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DU497_RS03085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DU497_RS03090	COG0735	belongs to the Fur family
DU497_RS03095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DU497_RS03100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DU497_RS03105	COG0151	Belongs to the GarS family
DU497_RS03120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DU497_RS03175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DU497_RS03255	COG0284	orotidine-5'-phosphate decarboxylase activity
DU497_RS03280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DU497_RS03295	COG0560	Phosphoserine phosphatase
DU497_RS03300	COG0586	Pfam SNARE associated Golgi protein
DU497_RS03310	COG4122	O-methyltransferase activity
DU497_RS03340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DU497_RS03380	COG0714	Associated with various cellular activities
DU497_RS03395	COG1278	Cold shock
DU497_RS03415	COG0745	RESPONSE REGULATOR receiver
DU497_RS03420	COG2205	protein histidine kinase activity
DU497_RS03425	COG1278	Cold shock
DU497_RS03460	COG1196	nuclear chromosome segregation
DU497_RS03470	COG1126	abc transporter atp-binding protein
DU497_RS03475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DU497_RS03480	COG0765	amino acid transport
DU497_RS03485	COG0765	amino acid transport
DU497_RS03490	COG2326	polyphosphate kinase activity
DU497_RS03505	COG2814	Major facilitator Superfamily
DU497_RS03510	COG1022	Amp-dependent synthetase and ligase
DU497_RS03515	COG3328	transposase activity
DU497_RS03540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DU497_RS03550	COG0656	L-ascorbic acid biosynthetic process
DU497_RS03575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DU497_RS03595	COG0489	protein tyrosine kinase activity
DU497_RS03595	COG2151	metal-sulfur cluster biosynthetic enzyme
DU497_RS03600	COG4721	ABC-type cobalt transport system, permease component
DU497_RS03625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DU497_RS03665	COG4721	ABC-type cobalt transport system, permease component
DU497_RS03670	COG4172	Belongs to the ABC transporter superfamily
DU497_RS03675	COG1136	(ABC) transporter
DU497_RS03680	COG0577	efflux transmembrane transporter activity
DU497_RS03690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DU497_RS03780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DU497_RS03785	COG0569	domain protein
DU497_RS03800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DU497_RS03820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DU497_RS03840	COG0799	negative regulation of ribosome biogenesis
DU497_RS03870	COG0406	alpha-ribazole phosphatase activity
DU497_RS03875	COG0598	Magnesium transport protein CorA
DU497_RS03905	COG0802	atpase or kinase
DU497_RS03960	COG0516	GMP reductase activity
DU497_RS03970	COG1022	Amp-dependent synthetase and ligase
DU497_RS04000	COG0575	Belongs to the CDS family
DU497_RS04040	COG1573	uracil-dna glycosylase
DU497_RS04050	COG0133	tryptophan synthase activity
DU497_RS04065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DU497_RS04080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DU497_RS04100	COG1716	ATPase activity
DU497_RS04115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DU497_RS04120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DU497_RS04175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DU497_RS04200	COG0045	succinate-CoA ligase (ADP-forming) activity
DU497_RS04235	COG0438	transferase activity, transferring glycosyl groups
DU497_RS04240	COG1560	Kdo2-lipid A biosynthetic process
DU497_RS04255	COG0488	(ABC) transporter
DU497_RS04265	COG0456	acetyltransferase
DU497_RS04335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DU497_RS04345	COG0436	Aminotransferase
DU497_RS04355	COG0436	Aminotransferase
DU497_RS04360	COG0561	phosphatase activity
DU497_RS04365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DU497_RS04390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DU497_RS04425	COG0488	(ABC) transporter
DU497_RS04450	COG0450	alkyl hydroperoxide reductase
DU497_RS04460	COG0583	DNA-binding transcription factor activity
DU497_RS04500	COG0167	dihydroorotate dehydrogenase activity
DU497_RS04510	COG0284	orotidine-5'-phosphate decarboxylase activity
DU497_RS04515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DU497_RS04535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DU497_RS04555	COG1119	ATPase activity
DU497_RS04560	COG0297	glycogen (starch) synthase activity
DU497_RS04580	COG0070	glutamate synthase
DU497_RS04580	COG0069	glutamate synthase activity
DU497_RS04580	COG0067	glutamate synthase
DU497_RS04600	COG2860	membrane
DU497_RS04605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DU497_RS04630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DU497_RS04655	COG1702	phosphate starvation-inducible protein PhoH
DU497_RS04660	COG0537	adenosine 5'-monophosphoramidase activity
DU497_RS04665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DU497_RS04690	COG2151	metal-sulfur cluster biosynthetic enzyme
DU497_RS04695	COG0822	iron-sulfur transferase activity
DU497_RS04705	COG0396	ATPase activity
DU497_RS04710	COG0719	Fe-S assembly protein
DU497_RS04720	COG1376	ErfK ybiS ycfS ynhG family protein
DU497_RS04735	COG1523	belongs to the glycosyl hydrolase 13 family
DU497_RS04780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DU497_RS04825	COG0588	phosphoglycerate mutase activity
DU497_RS04830	COG1950	PFAM Membrane protein of
DU497_RS04865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DU497_RS04880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DU497_RS04895	COG1131	(ABC) transporter
DU497_RS04900	COG1725	Transcriptional regulator
DU497_RS04910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DU497_RS04935	COG0563	adenylate kinase activity
DU497_RS04955	COG3039	Transposase
DU497_RS04975	COG0280	phosphate acetyltransferase
DU497_RS04975	COG0857	belongs to the CobB CobQ family
DU497_RS04980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DU497_RS05010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DU497_RS05025	COG0494	nUDIX hydrolase
DU497_RS05035	COG0469	pyruvate kinase activity
DU497_RS05050	COG0237	dephospho-CoA kinase activity
DU497_RS05055	COG0539	negative regulation of cytoplasmic translation
DU497_RS05065	COG0803	Belongs to the bacterial solute-binding protein 9 family
DU497_RS05070	COG1121	(ABC) transporter
DU497_RS05085	COG1329	Transcriptional regulator
DU497_RS05095	COG0745	RESPONSE REGULATOR receiver
DU497_RS05100	COG2205	protein histidine kinase activity
DU497_RS05130	COG1316	TRANSCRIPTIONal
DU497_RS05135	COG1316	TRANSCRIPTIONal
DU497_RS05160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DU497_RS05170	COG1760	l-serine dehydratase
DU497_RS05215	COG1116	anion transmembrane transporter activity
DU497_RS05240	COG1472	Belongs to the glycosyl hydrolase 3 family
DU497_RS05250	COG1966	Carbon starvation protein
DU497_RS05290	COG1918	ferrous iron import across plasma membrane
DU497_RS05290	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DU497_RS05315	COG0363	glucosamine-6-phosphate deaminase activity
DU497_RS05320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DU497_RS05325	COG3340	Belongs to the peptidase S51 family
DU497_RS05330	COG1114	Component of the transport system for branched-chain amino acids
DU497_RS05360	COG2233	PERMEase
DU497_RS05380	COG0012	GTP binding
DU497_RS05385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DU497_RS05395	COG4585	Histidine kinase
DU497_RS05400	COG2197	response regulator
DU497_RS05410	COG1136	(ABC) transporter
DU497_RS05410	COG0577	efflux transmembrane transporter activity
DU497_RS05420	COG1122	ATPase activity
DU497_RS05425	COG2873	o-acetylhomoserine
DU497_RS05455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DU497_RS05520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DU497_RS05525	COG1882	Formate acetyltransferase
DU497_RS05540	COG1473	amidohydrolase
DU497_RS05545	COG2011	ABC-type metal ion transport system permease component
DU497_RS05555	COG1464	Belongs to the NlpA lipoprotein family
DU497_RS05560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DU497_RS05565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DU497_RS05590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DU497_RS05595	COG4975	Glucose uptake
DU497_RS05600	COG1201	RNA secondary structure unwinding
DU497_RS05625	COG0187	DNA topoisomerase II activity
DU497_RS05630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DU497_RS05640	COG0142	geranyltranstransferase activity
DU497_RS05660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DU497_RS05670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DU497_RS05695	COG1396	sequence-specific DNA binding
DU497_RS05705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DU497_RS05725	COG2357	RelA SpoT domain protein
DU497_RS05730	COG0670	Belongs to the BI1 family
DU497_RS05735	COG3804	dihydrodipicolinate reductase
DU497_RS05750	COG1131	(ABC) transporter
DU497_RS05755	COG4585	Histidine kinase
DU497_RS05760	COG2197	response regulator
DU497_RS05780	COG2182	Extracellular solute-binding protein
DU497_RS05795	COG0110	maltose O-acetyltransferase activity
DU497_RS05805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DU497_RS05835	COG0708	Exodeoxyribonuclease III
DU497_RS05850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DU497_RS05855	COG0601	transmembrane transport
DU497_RS05860	COG4166	transmembrane transport
DU497_RS05870	COG1136	(ABC) transporter
DU497_RS05875	COG0577	efflux transmembrane transporter activity
DU497_RS05885	COG0287	Prephenate dehydrogenase
DU497_RS05900	COG1217	gtp-binding protein TYPA
DU497_RS05905	COG0477	Major facilitator Superfamily
DU497_RS05935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DU497_RS05950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DU497_RS05960	COG2017	converts alpha-aldose to the beta-anomer
DU497_RS05985	COG0285	dihydrofolate synthase activity
DU497_RS06005	COG0006	proline dipeptidase activity
DU497_RS06010	COG2816	NAD+ diphosphatase activity
DU497_RS06030	COG0582	viral genome integration into host DNA
DU497_RS06115	COG0601	transmembrane transport
DU497_RS06155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DU497_RS06165	COG0768	penicillin binding
DU497_RS06190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DU497_RS06210	COG1230	cation diffusion facilitator family transporter
DU497_RS06220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DU497_RS06230	COG1643	Atp-dependent helicase
DU497_RS06275	COG0587	DNA-directed DNA polymerase activity
DU497_RS06310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DU497_RS06360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DU497_RS06365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DU497_RS06370	COG1957	nucleoside hydrolase
DU497_RS06420	COG3480	Lon protease (S16) C-terminal proteolytic domain
DU497_RS06445	COG0613	PHP domain protein
DU497_RS06455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DU497_RS06480	COG1126	abc transporter atp-binding protein
DU497_RS06485	COG0765	amino acid transport
DU497_RS06490	COG0765	amino acid transport
DU497_RS06495	COG0436	Aminotransferase
DU497_RS06505	COG2011	ABC-type metal ion transport system permease component
DU497_RS06515	COG1464	Belongs to the NlpA lipoprotein family
DU497_RS06520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DU497_RS06585	COG4166	transmembrane transport
DU497_RS06590	COG2814	Major facilitator Superfamily
DU497_RS06595	COG1842	Phage shock protein A
DU497_RS06615	COG2365	Tyrosine phosphatase family
DU497_RS06630	COG1132	(ABC) transporter
DU497_RS06635	COG1132	(ABC) transporter
DU497_RS06690	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DU497_RS06695	COG1518	maintenance of DNA repeat elements
DU497_RS06695	COG1468	defense response to virus
DU497_RS06730	COG1328	CTP reductase activity
DU497_RS06730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DU497_RS06735	COG1570	exodeoxyribonuclease VII activity
DU497_RS06740	COG1722	exodeoxyribonuclease VII activity
DU497_RS06760	COG0436	Aminotransferase
DU497_RS06795	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DU497_RS06820	COG0210	DNA helicase
DU497_RS06840	COG0714	Associated with various cellular activities
DU497_RS06880	COG1194	a g-specific adenine glycosylase
DU497_RS06885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DU497_RS06905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DU497_RS06915	COG1349	DNA-binding transcription factor activity
DU497_RS06920	COG1216	Glycosyl transferase, family 2
DU497_RS06925	COG0167	dihydroorotate dehydrogenase activity
DU497_RS06930	COG1902	pentaerythritol trinitrate reductase activity
DU497_RS06935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DU497_RS06935	COG4499	WXG100 protein secretion system (Wss), protein YukC
DU497_RS06945	COG0095	Lipoate-protein ligase
DU497_RS06990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DU497_RS07025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DU497_RS07035	COG1088	dTDP-glucose 4,6-dehydratase activity
DU497_RS07055	COG1442	glycosyl transferase family 8
DU497_RS07055	COG1216	Glycosyl transferase, family 2
DU497_RS07105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DU497_RS07115	COG2814	Major facilitator Superfamily
DU497_RS07170	COG4988	ABC transporter
DU497_RS07185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DU497_RS07195	COG0489	protein tyrosine kinase activity
DU497_RS07215	COG0083	homoserine kinase activity
DU497_RS07220	COG0460	homoserine dehydrogenase
DU497_RS07225	COG0019	diaminopimelate decarboxylase activity
DU497_RS07240	COG0251	oxidation-reduction process
DU497_RS07245	COG0395	ABC-type sugar transport system, permease component
DU497_RS07250	COG3459	Glycosyltransferase 36 associated
DU497_RS07275	COG0545	Peptidyl-prolyl cis-trans isomerase
DU497_RS07285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DU497_RS07320	COG0356	it plays a direct role in the translocation of protons across the membrane
DU497_RS07330	COG0477	Major facilitator Superfamily
DU497_RS07385	COG0582	viral genome integration into host DNA
DU497_RS07405	COG0679	Auxin Efflux Carrier
DU497_RS07410	COG0028	Belongs to the TPP enzyme family
DU497_RS07435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DU497_RS07445	COG0745	RESPONSE REGULATOR receiver
DU497_RS07455	COG0747	negative chemotaxis
DU497_RS07470	COG1605	Chorismate mutase
DU497_RS07470	COG0287	Prephenate dehydrogenase
DU497_RS07535	COG2217	Heavy metal translocating P-type atpase
DU497_RS07545	COG0179	Fumarylacetoacetate (FAA) hydrolase
DU497_RS07570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DU497_RS07585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DU497_RS07640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DU497_RS07655	COG1609	Transcriptional regulator
DU497_RS07700	COG1368	sulfuric ester hydrolase activity
DU497_RS07710	COG1368	sulfuric ester hydrolase activity
DU497_RS07715	COG1216	Glycosyl transferase, family 2
DU497_RS07765	COG1216	Glycosyl transferase, family 2
DU497_RS07820	COG0084	hydrolase, TatD family'
DU497_RS07835	COG1132	(ABC) transporter
DU497_RS07840	COG1132	(ABC) transporter
DU497_RS07880	COG0586	Pfam SNARE associated Golgi protein
DU497_RS07900	COG1309	transcriptional regulator
DU497_RS07905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DU497_RS07910	COG0789	Transcriptional regulator
DU497_RS07915	COG0484	heat shock protein binding
DU497_RS07945	COG1523	belongs to the glycosyl hydrolase 13 family
DU497_RS07950	COG3833	ABC-type maltose transport systems, permease component
DU497_RS07955	COG1175	transmembrane transport
DU497_RS07965	COG0366	Alpha amylase catalytic
DU497_RS07990	COG1609	Transcriptional regulator
DU497_RS08000	COG0366	Alpha amylase catalytic
DU497_RS08015	COG0778	Nitroreductase
DU497_RS08025	COG2814	Major facilitator Superfamily
DU497_RS08060	COG1609	Transcriptional regulator
DU497_RS08065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DU497_RS08070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DU497_RS08075	COG0366	Alpha amylase catalytic
DU497_RS08095	COG0395	ABC-type sugar transport system, permease component
DU497_RS08100	COG1175	transmembrane transport
DU497_RS08120	COG0037	tRNA processing
DU497_RS08120	COG0590	tRNA wobble adenosine to inosine editing
DU497_RS08125	COG0025	NhaP-type Na H and K H
DU497_RS08145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DU497_RS08155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DU497_RS08165	COG3842	ATPase activity
DU497_RS08170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DU497_RS08190	COG3583	domain protein
DU497_RS08210	COG0617	tRNA 3'-terminal CCA addition
DU497_RS08230	COG0492	ferredoxin-NADP+ reductase activity
DU497_RS08235	COG1475	DNA binding
DU497_RS08240	COG1192	Involved in chromosome partitioning
DU497_RS08250	COG1847	R3H domain protein