locus-tag	class	description
D0Y52_RS00010	COG0305	Participates in initiation and elongation during chromosome replication
D0Y52_RS00020	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0Y52_RS00040	COG1309	transcriptional regulator
D0Y52_RS00075	COG1129	ABC transporter
D0Y52_RS00120	COG0110	maltose O-acetyltransferase activity
D0Y52_RS00125	COG0671	phosphoesterase, PA-phosphatase related
D0Y52_RS00145	COG1846	Transcriptional regulator
D0Y52_RS00155	COG0577	efflux transmembrane transporter activity
D0Y52_RS00155	COG1136	(ABC) transporter
D0Y52_RS00160	COG0577	efflux transmembrane transporter activity
D0Y52_RS00175	COG1113	amino acid transport
D0Y52_RS00185	COG1136	(ABC) transporter
D0Y52_RS00185	COG0577	efflux transmembrane transporter activity
D0Y52_RS00190	COG1113	amino acid transport
D0Y52_RS00195	COG0390	transport system, permease component
D0Y52_RS00200	COG1132	(ABC) transporter
D0Y52_RS00255	COG0477	Major facilitator Superfamily
D0Y52_RS00285	COG4770	biotin carboxylase activity
D0Y52_RS00295	COG2211	Major facilitator Superfamily
D0Y52_RS00345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Y52_RS00355	COG0191	fructose-bisphosphate aldolase activity
D0Y52_RS00365	COG0583	DNA-binding transcription factor activity
D0Y52_RS00370	COG1063	alcohol dehydrogenase
D0Y52_RS00410	COG0667	Aldo Keto reductase
D0Y52_RS00440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0Y52_RS00455	COG2814	Major facilitator Superfamily
D0Y52_RS00480	COG0343	queuine tRNA-ribosyltransferase activity
D0Y52_RS00495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Y52_RS00500	COG2217	Heavy metal translocating P-type atpase
D0Y52_RS00525	COG2261	transglycosylase associated protein
D0Y52_RS00530	COG2261	transglycosylase associated protein
D0Y52_RS00540	COG2226	methyltransferase
D0Y52_RS00555	COG0697	spore germination
D0Y52_RS00590	COG0768	penicillin binding
D0Y52_RS00595	COG0515	serine threonine protein kinase
D0Y52_RS00610	COG3764	Sortase (surface protein transpeptidase)
D0Y52_RS00650	COG0058	SHG alpha-glucan phosphorylase activity
D0Y52_RS00665	COG0180	Tryptophanyl-tRNA synthetase
D0Y52_RS00680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0Y52_RS00685	COG0656	L-ascorbic acid biosynthetic process
D0Y52_RS00705	COG3534	alpha-L-arabinofuranosidase
D0Y52_RS00710	COG1609	Transcriptional regulator
D0Y52_RS00730	COG1609	Transcriptional regulator
D0Y52_RS00735	COG0288	reversible hydration of carbon dioxide
D0Y52_RS00740	COG1253	flavin adenine dinucleotide binding
D0Y52_RS00745	COG0783	Belongs to the Dps family
D0Y52_RS00785	COG3231	kanamycin kinase activity
D0Y52_RS00800	COG0583	DNA-binding transcription factor activity
D0Y52_RS00905	COG2226	methyltransferase
D0Y52_RS00910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Y52_RS00955	COG1970	mechanosensitive ion channel activity
D0Y52_RS00970	COG2814	Major facilitator Superfamily
D0Y52_RS00975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0Y52_RS00980	COG1272	protein, Hemolysin III
D0Y52_RS00995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0Y52_RS01000	COG0187	DNA topoisomerase II activity
D0Y52_RS01015	COG0592	DNA-directed DNA polymerase activity
D0Y52_RS01045	COG1847	R3H domain protein
D0Y52_RS01055	COG1192	Involved in chromosome partitioning
D0Y52_RS01060	COG1475	DNA binding
D0Y52_RS01065	COG0492	ferredoxin-NADP+ reductase activity
D0Y52_RS01085	COG0617	tRNA 3'-terminal CCA addition
D0Y52_RS01105	COG3583	domain protein
D0Y52_RS01125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0Y52_RS01130	COG3842	ATPase activity
D0Y52_RS01140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Y52_RS01150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0Y52_RS01170	COG0025	NhaP-type Na H and K H
D0Y52_RS01175	COG0037	tRNA processing
D0Y52_RS01175	COG0590	tRNA wobble adenosine to inosine editing
D0Y52_RS01195	COG1175	transmembrane transport
D0Y52_RS01200	COG0395	ABC-type sugar transport system, permease component
D0Y52_RS01220	COG0366	Alpha amylase catalytic
D0Y52_RS01225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0Y52_RS01230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0Y52_RS01235	COG1609	Transcriptional regulator
D0Y52_RS01310	COG2814	Major facilitator Superfamily
D0Y52_RS01320	COG0778	Nitroreductase
D0Y52_RS01335	COG0366	Alpha amylase catalytic
D0Y52_RS01345	COG1609	Transcriptional regulator
D0Y52_RS01370	COG0366	Alpha amylase catalytic
D0Y52_RS01380	COG1175	transmembrane transport
D0Y52_RS01385	COG3833	ABC-type maltose transport systems, permease component
D0Y52_RS01390	COG1523	belongs to the glycosyl hydrolase 13 family
D0Y52_RS01420	COG0484	heat shock protein binding
D0Y52_RS01425	COG0789	Transcriptional regulator
D0Y52_RS01430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y52_RS01435	COG1309	transcriptional regulator
D0Y52_RS01455	COG0586	Pfam SNARE associated Golgi protein
D0Y52_RS01495	COG1132	(ABC) transporter
D0Y52_RS01500	COG1132	(ABC) transporter
D0Y52_RS01515	COG0084	hydrolase, TatD family'
D0Y52_RS01570	COG1216	Glycosyl transferase, family 2
D0Y52_RS01620	COG1216	Glycosyl transferase, family 2
D0Y52_RS01625	COG1368	sulfuric ester hydrolase activity
D0Y52_RS01635	COG1368	sulfuric ester hydrolase activity
D0Y52_RS01680	COG1609	Transcriptional regulator
D0Y52_RS01695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Y52_RS01745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y52_RS01760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0Y52_RS01785	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0Y52_RS01795	COG2217	Heavy metal translocating P-type atpase
D0Y52_RS01860	COG1605	Chorismate mutase
D0Y52_RS01860	COG0287	Prephenate dehydrogenase
D0Y52_RS01875	COG0747	negative chemotaxis
D0Y52_RS01885	COG0745	RESPONSE REGULATOR receiver
D0Y52_RS01895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0Y52_RS01920	COG0028	Belongs to the TPP enzyme family
D0Y52_RS01925	COG0679	Auxin Efflux Carrier
D0Y52_RS01945	COG0582	viral genome integration into host DNA
D0Y52_RS02000	COG0477	Major facilitator Superfamily
D0Y52_RS02010	COG0356	it plays a direct role in the translocation of protons across the membrane
D0Y52_RS02045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0Y52_RS02055	COG0545	Peptidyl-prolyl cis-trans isomerase
D0Y52_RS02080	COG3459	Glycosyltransferase 36 associated
D0Y52_RS02085	COG0395	ABC-type sugar transport system, permease component
D0Y52_RS02090	COG0251	oxidation-reduction process
D0Y52_RS02105	COG0019	diaminopimelate decarboxylase activity
D0Y52_RS02110	COG0460	homoserine dehydrogenase
D0Y52_RS02115	COG0083	homoserine kinase activity
D0Y52_RS02135	COG0489	protein tyrosine kinase activity
D0Y52_RS02145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Y52_RS02160	COG4988	ABC transporter
D0Y52_RS02215	COG2814	Major facilitator Superfamily
D0Y52_RS02225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0Y52_RS02275	COG1442	glycosyl transferase family 8
D0Y52_RS02275	COG1216	Glycosyl transferase, family 2
D0Y52_RS02295	COG1088	dTDP-glucose 4,6-dehydratase activity
D0Y52_RS02305	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D0Y52_RS02340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Y52_RS02385	COG0095	Lipoate-protein ligase
D0Y52_RS02395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Y52_RS02395	COG4499	WXG100 protein secretion system (Wss), protein YukC
D0Y52_RS02400	COG1902	pentaerythritol trinitrate reductase activity
D0Y52_RS02405	COG0167	dihydroorotate dehydrogenase activity
D0Y52_RS02410	COG1216	Glycosyl transferase, family 2
D0Y52_RS02415	COG1349	DNA-binding transcription factor activity
D0Y52_RS02425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D0Y52_RS02445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0Y52_RS02450	COG1194	a g-specific adenine glycosylase
D0Y52_RS02490	COG0714	Associated with various cellular activities
D0Y52_RS02510	COG0210	DNA helicase
D0Y52_RS02535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D0Y52_RS02570	COG0436	Aminotransferase
D0Y52_RS02590	COG1722	exodeoxyribonuclease VII activity
D0Y52_RS02595	COG1570	exodeoxyribonuclease VII activity
D0Y52_RS02600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0Y52_RS02600	COG1328	CTP reductase activity
D0Y52_RS02635	COG1518	maintenance of DNA repeat elements
D0Y52_RS02635	COG1468	defense response to virus
D0Y52_RS02640	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D0Y52_RS02695	COG1132	(ABC) transporter
D0Y52_RS02700	COG1132	(ABC) transporter
D0Y52_RS02715	COG2365	Tyrosine phosphatase family
D0Y52_RS02740	COG1842	Phage shock protein A
D0Y52_RS02745	COG2814	Major facilitator Superfamily
D0Y52_RS02750	COG4166	transmembrane transport
D0Y52_RS02815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0Y52_RS02820	COG1464	Belongs to the NlpA lipoprotein family
D0Y52_RS02830	COG2011	ABC-type metal ion transport system permease component
D0Y52_RS02840	COG0436	Aminotransferase
D0Y52_RS02845	COG0765	amino acid transport
D0Y52_RS02850	COG0765	amino acid transport
D0Y52_RS02855	COG1126	abc transporter atp-binding protein
D0Y52_RS02880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0Y52_RS02890	COG0613	PHP domain protein
D0Y52_RS02915	COG3480	Lon protease (S16) C-terminal proteolytic domain
D0Y52_RS02970	COG1957	nucleoside hydrolase
D0Y52_RS02975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0Y52_RS02980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Y52_RS03030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0Y52_RS03065	COG0587	DNA-directed DNA polymerase activity
D0Y52_RS03110	COG1643	Atp-dependent helicase
D0Y52_RS03120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0Y52_RS03130	COG1230	cation diffusion facilitator family transporter
D0Y52_RS03150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Y52_RS03175	COG0768	penicillin binding
D0Y52_RS03185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0Y52_RS03225	COG0601	transmembrane transport
D0Y52_RS03310	COG0582	viral genome integration into host DNA
D0Y52_RS03330	COG2816	NAD+ diphosphatase activity
D0Y52_RS03335	COG0006	proline dipeptidase activity
D0Y52_RS03355	COG0285	dihydrofolate synthase activity
D0Y52_RS03380	COG2017	converts alpha-aldose to the beta-anomer
D0Y52_RS03390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0Y52_RS03405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D0Y52_RS03435	COG0477	Major facilitator Superfamily
D0Y52_RS03440	COG1217	gtp-binding protein TYPA
D0Y52_RS03455	COG0287	Prephenate dehydrogenase
D0Y52_RS03465	COG0577	efflux transmembrane transporter activity
D0Y52_RS03470	COG1136	(ABC) transporter
D0Y52_RS03480	COG4166	transmembrane transport
D0Y52_RS03485	COG0601	transmembrane transport
D0Y52_RS03490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Y52_RS03505	COG0708	Exodeoxyribonuclease III
D0Y52_RS03535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0Y52_RS03545	COG0110	maltose O-acetyltransferase activity
D0Y52_RS03560	COG2182	Extracellular solute-binding protein
D0Y52_RS03565	COG0366	Alpha amylase catalytic
D0Y52_RS03580	COG2197	response regulator
D0Y52_RS03585	COG4585	Histidine kinase
D0Y52_RS03590	COG1131	(ABC) transporter
D0Y52_RS03605	COG3804	dihydrodipicolinate reductase
D0Y52_RS03610	COG0670	Belongs to the BI1 family
D0Y52_RS03615	COG2357	RelA SpoT domain protein
D0Y52_RS03635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0Y52_RS03645	COG1396	sequence-specific DNA binding
D0Y52_RS03670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0Y52_RS03680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0Y52_RS03700	COG0142	geranyltranstransferase activity
D0Y52_RS03710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0Y52_RS03715	COG0187	DNA topoisomerase II activity
D0Y52_RS03740	COG1201	RNA secondary structure unwinding
D0Y52_RS03745	COG4975	Glucose uptake
D0Y52_RS03750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0Y52_RS03775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Y52_RS03780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0Y52_RS03785	COG1464	Belongs to the NlpA lipoprotein family
D0Y52_RS03795	COG2011	ABC-type metal ion transport system permease component
D0Y52_RS03800	COG1473	amidohydrolase
D0Y52_RS03815	COG1882	Formate acetyltransferase
D0Y52_RS03820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0Y52_RS03885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0Y52_RS03915	COG2873	o-acetylhomoserine
D0Y52_RS03920	COG1122	ATPase activity
D0Y52_RS03930	COG1136	(ABC) transporter
D0Y52_RS03930	COG0577	efflux transmembrane transporter activity
D0Y52_RS03940	COG2197	response regulator
D0Y52_RS03945	COG4585	Histidine kinase
D0Y52_RS03955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0Y52_RS03960	COG0012	GTP binding
D0Y52_RS03980	COG2233	PERMEase
D0Y52_RS04010	COG1114	Component of the transport system for branched-chain amino acids
D0Y52_RS04015	COG3340	Belongs to the peptidase S51 family
D0Y52_RS04020	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0Y52_RS04025	COG0363	glucosamine-6-phosphate deaminase activity
D0Y52_RS04050	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D0Y52_RS04050	COG1918	ferrous iron import across plasma membrane
D0Y52_RS04090	COG1966	Carbon starvation protein
D0Y52_RS04100	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Y52_RS04125	COG1116	anion transmembrane transporter activity
D0Y52_RS04170	COG1760	l-serine dehydratase
D0Y52_RS04180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y52_RS04205	COG1316	TRANSCRIPTIONal
D0Y52_RS04210	COG1316	TRANSCRIPTIONal
D0Y52_RS04240	COG2205	protein histidine kinase activity
D0Y52_RS04245	COG0745	RESPONSE REGULATOR receiver
D0Y52_RS04255	COG1329	Transcriptional regulator
D0Y52_RS04270	COG1121	(ABC) transporter
D0Y52_RS04275	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0Y52_RS04285	COG0539	negative regulation of cytoplasmic translation
D0Y52_RS04290	COG0237	dephospho-CoA kinase activity
D0Y52_RS04305	COG0469	pyruvate kinase activity
D0Y52_RS04315	COG0494	nUDIX hydrolase
D0Y52_RS04330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0Y52_RS04360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0Y52_RS04365	COG0857	belongs to the CobB CobQ family
D0Y52_RS04365	COG0280	phosphate acetyltransferase
D0Y52_RS04385	COG3039	Transposase
D0Y52_RS04405	COG0563	adenylate kinase activity
D0Y52_RS04430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0Y52_RS04440	COG1725	Transcriptional regulator
D0Y52_RS04445	COG1131	(ABC) transporter
D0Y52_RS04460	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D0Y52_RS04475	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0Y52_RS04510	COG1950	PFAM Membrane protein of
D0Y52_RS04515	COG0588	phosphoglycerate mutase activity
D0Y52_RS04560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0Y52_RS04605	COG1523	belongs to the glycosyl hydrolase 13 family
D0Y52_RS04620	COG1376	ErfK ybiS ycfS ynhG family protein
D0Y52_RS04630	COG0719	Fe-S assembly protein
D0Y52_RS04635	COG0396	ATPase activity
D0Y52_RS04645	COG0822	iron-sulfur transferase activity
D0Y52_RS04650	COG2151	metal-sulfur cluster biosynthetic enzyme
D0Y52_RS04675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0Y52_RS04680	COG0537	adenosine 5'-monophosphoramidase activity
D0Y52_RS04685	COG1702	phosphate starvation-inducible protein PhoH
D0Y52_RS04710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D0Y52_RS04735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0Y52_RS04740	COG2860	membrane
D0Y52_RS04760	COG0069	glutamate synthase activity
D0Y52_RS04760	COG0070	glutamate synthase
D0Y52_RS04760	COG0067	glutamate synthase
D0Y52_RS04780	COG0297	glycogen (starch) synthase activity
D0Y52_RS04785	COG1119	ATPase activity
D0Y52_RS04805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0Y52_RS04830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0Y52_RS04835	COG0284	orotidine-5'-phosphate decarboxylase activity
D0Y52_RS04845	COG0167	dihydroorotate dehydrogenase activity
D0Y52_RS04885	COG0583	DNA-binding transcription factor activity
D0Y52_RS04895	COG0450	alkyl hydroperoxide reductase
D0Y52_RS04920	COG0488	(ABC) transporter
D0Y52_RS04950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0Y52_RS04975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0Y52_RS04980	COG0561	phosphatase activity
D0Y52_RS04985	COG0436	Aminotransferase
D0Y52_RS04995	COG0436	Aminotransferase
D0Y52_RS05005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0Y52_RS05075	COG0456	acetyltransferase
D0Y52_RS05085	COG0488	(ABC) transporter
D0Y52_RS05100	COG1560	Kdo2-lipid A biosynthetic process
D0Y52_RS05105	COG0438	transferase activity, transferring glycosyl groups
D0Y52_RS05140	COG0045	succinate-CoA ligase (ADP-forming) activity
D0Y52_RS05165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y52_RS05220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Y52_RS05225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Y52_RS05240	COG1716	ATPase activity
D0Y52_RS05260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0Y52_RS05275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0Y52_RS05290	COG0133	tryptophan synthase activity
D0Y52_RS05300	COG1573	uracil-dna glycosylase
D0Y52_RS05340	COG0575	Belongs to the CDS family
D0Y52_RS05370	COG1022	Amp-dependent synthetase and ligase
D0Y52_RS05380	COG0516	GMP reductase activity
D0Y52_RS05435	COG0802	atpase or kinase
D0Y52_RS05465	COG0598	Magnesium transport protein CorA
D0Y52_RS05470	COG0406	alpha-ribazole phosphatase activity
D0Y52_RS05500	COG0799	negative regulation of ribosome biogenesis
D0Y52_RS05520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0Y52_RS05540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y52_RS05555	COG0569	domain protein
D0Y52_RS05560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0Y52_RS05650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Y52_RS05660	COG0577	efflux transmembrane transporter activity
D0Y52_RS05665	COG1136	(ABC) transporter
D0Y52_RS05670	COG4172	Belongs to the ABC transporter superfamily
D0Y52_RS05675	COG4721	ABC-type cobalt transport system, permease component
D0Y52_RS05715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Y52_RS05740	COG4721	ABC-type cobalt transport system, permease component
D0Y52_RS05745	COG2151	metal-sulfur cluster biosynthetic enzyme
D0Y52_RS05745	COG0489	protein tyrosine kinase activity
D0Y52_RS05765	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D0Y52_RS05790	COG0656	L-ascorbic acid biosynthetic process
D0Y52_RS05800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D0Y52_RS05825	COG3328	transposase activity
D0Y52_RS05830	COG1022	Amp-dependent synthetase and ligase
D0Y52_RS05835	COG2814	Major facilitator Superfamily
D0Y52_RS05850	COG2326	polyphosphate kinase activity
D0Y52_RS05855	COG0765	amino acid transport
D0Y52_RS05860	COG0765	amino acid transport
D0Y52_RS05865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y52_RS05870	COG1126	abc transporter atp-binding protein
D0Y52_RS05880	COG1196	nuclear chromosome segregation
D0Y52_RS05915	COG1278	Cold shock
D0Y52_RS05920	COG2205	protein histidine kinase activity
D0Y52_RS05925	COG0745	RESPONSE REGULATOR receiver
D0Y52_RS05945	COG1278	Cold shock
D0Y52_RS05960	COG0714	Associated with various cellular activities
D0Y52_RS06000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0Y52_RS06030	COG4122	O-methyltransferase activity
D0Y52_RS06040	COG0586	Pfam SNARE associated Golgi protein
D0Y52_RS06045	COG0560	Phosphoserine phosphatase
D0Y52_RS06060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Y52_RS06085	COG0284	orotidine-5'-phosphate decarboxylase activity
D0Y52_RS06165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0Y52_RS06220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0Y52_RS06235	COG0151	Belongs to the GarS family
D0Y52_RS06240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D0Y52_RS06245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D0Y52_RS06250	COG0735	belongs to the Fur family
D0Y52_RS06255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0Y52_RS06260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0Y52_RS06265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0Y52_RS06275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0Y52_RS06280	COG0358	DNA primase activity
D0Y52_RS06285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0Y52_RS06300	COG0371	Dehydrogenase
D0Y52_RS06385	COG0514	ATP-dependent DNA helicase (RecQ)
D0Y52_RS06400	COG4172	Belongs to the ABC transporter superfamily
D0Y52_RS06410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Y52_RS06415	COG0601	transmembrane transport
D0Y52_RS06420	COG0747	negative chemotaxis
D0Y52_RS06440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Y52_RS06445	COG2198	Histidine kinase
D0Y52_RS06445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y52_RS06445	COG0784	Response regulator, receiver
D0Y52_RS06445	COG2205	protein histidine kinase activity
D0Y52_RS06460	COG0765	amino acid transport
D0Y52_RS06465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y52_RS06485	COG1388	LysM domain
D0Y52_RS06485	COG3942	CHAP domain
D0Y52_RS06495	COG2884	Cell division ATP-binding protein ftsE
D0Y52_RS06500	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D0Y52_RS06520	COG0372	Belongs to the citrate synthase family
D0Y52_RS06525	COG0024	Methionine aminopeptidase
D0Y52_RS06535	COG3590	peptidase
D0Y52_RS06555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0Y52_RS06560	COG0561	phosphatase activity
D0Y52_RS06580	COG0009	L-threonylcarbamoyladenylate synthase
D0Y52_RS06600	COG1940	carbohydrate kinase activity
D0Y52_RS06605	COG1070	Carbohydrate kinase
D0Y52_RS06615	COG2272	Belongs to the type-B carboxylesterase lipase family
D0Y52_RS06625	COG3507	Belongs to the glycosyl hydrolase 43 family
D0Y52_RS06635	COG1175	transmembrane transport
D0Y52_RS06650	COG3507	Belongs to the glycosyl hydrolase 43 family
D0Y52_RS06685	COG2873	o-acetylhomoserine
D0Y52_RS06690	COG0242	peptide deformylase activity
D0Y52_RS06700	COG1946	Acyl-CoA thioesterase
D0Y52_RS06715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0Y52_RS06750	COG0628	permease
D0Y52_RS06755	COG1216	Glycosyl transferase, family 2
D0Y52_RS06785	COG0395	ABC-type sugar transport system, permease component
D0Y52_RS06820	COG1609	Transcriptional regulator
D0Y52_RS06825	COG3250	beta-galactosidase activity
D0Y52_RS06835	COG3189	MarR family transcriptional regulator
D0Y52_RS06915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0Y52_RS06920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Y52_RS06925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0Y52_RS06945	COG0791	NLP P60 protein
D0Y52_RS06945	COG1388	LysM domain
D0Y52_RS06950	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0Y52_RS06950	COG3942	CHAP domain
D0Y52_RS06955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0Y52_RS06960	COG0704	Plays a role in the regulation of phosphate uptake
D0Y52_RS06965	COG5002	protein histidine kinase activity
D0Y52_RS06975	COG0604	alcohol dehydrogenase
D0Y52_RS06975	COG3321	synthase
D0Y52_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y52_RS06980	COG1063	alcohol dehydrogenase
D0Y52_RS06985	COG4716	Myosin-crossreactive antigen
D0Y52_RS07000	COG1113	amino acid transport
D0Y52_RS07010	COG0531	amino acid
D0Y52_RS07015	COG3579	cysteine-type endopeptidase activity
D0Y52_RS07030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0Y52_RS07040	COG2873	o-acetylhomoserine
D0Y52_RS07050	COG0626	cystathionine gamma-synthase activity
D0Y52_RS07070	COG2197	response regulator
D0Y52_RS07095	COG1597	lipid kinase activity
D0Y52_RS07095	COG1803	Methylglyoxal synthase
D0Y52_RS07115	COG0328	RNA-DNA hybrid ribonuclease activity
D0Y52_RS07140	COG0196	riboflavin kinase activity
D0Y52_RS07275	COG0255	Belongs to the universal ribosomal protein uL29 family
D0Y52_RS07335	COG1454	alcohol dehydrogenase
D0Y52_RS07335	COG1012	belongs to the aldehyde dehydrogenase family
D0Y52_RS07370	COG1739	Uncharacterized protein family UPF0029
D0Y52_RS07375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0Y52_RS07385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0Y52_RS07400	COG0531	amino acid
D0Y52_RS07405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0Y52_RS07490	COG2252	PERMEase
D0Y52_RS07500	COG0581	inorganic phosphate transmembrane transporter activity
D0Y52_RS07515	COG0745	RESPONSE REGULATOR receiver
D0Y52_RS07525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0Y52_RS07530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0Y52_RS07535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0Y52_RS07535	COG2755	lipolytic protein G-D-S-L family
D0Y52_RS07540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0Y52_RS07545	COG3579	cysteine-type endopeptidase activity
D0Y52_RS07555	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D0Y52_RS07575	COG0826	peptidase U32
D0Y52_RS07595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Y52_RS07600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Y52_RS07610	COG1704	LemA family
D0Y52_RS07625	COG0039	L-malate dehydrogenase activity
D0Y52_RS07650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0Y52_RS07655	COG4770	biotin carboxylase activity
D0Y52_RS07660	COG1268	BioY protein
D0Y52_RS07665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D0Y52_RS07665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D0Y52_RS07700	COG0436	Aminotransferase
D0Y52_RS07740	COG1530	ribonuclease E activity
D0Y52_RS07745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Y52_RS07765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0Y52_RS07835	COG0667	Aldo Keto reductase
D0Y52_RS07875	COG0440	acetolactate synthase activity
D0Y52_RS07885	COG0488	(ABC) transporter
D0Y52_RS07925	COG1837	Belongs to the UPF0109 family
D0Y52_RS07940	COG0742	ribosomal rna small subunit methyltransferase
D0Y52_RS07955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0Y52_RS07965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0Y52_RS07965	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D0Y52_RS07980	COG0436	Aminotransferase
D0Y52_RS08035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0Y52_RS08045	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y52_RS08110	COG0406	alpha-ribazole phosphatase activity
D0Y52_RS08175	COG1754	DNA topoisomerase type I activity
D0Y52_RS08175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0Y52_RS08190	COG1260	myo-inositol-1-phosphate synthase
D0Y52_RS08280	COG0406	alpha-ribazole phosphatase activity
D0Y52_RS08280	COG0494	nUDIX hydrolase