locus-tag	class	description
U723_RS00010	COG0592	DNA-directed DNA polymerase activity
U723_RS00025	COG0187	DNA topoisomerase II activity
U723_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U723_RS00045	COG1272	protein, Hemolysin III
U723_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U723_RS00055	COG2814	Major facilitator Superfamily
U723_RS00070	COG1970	mechanosensitive ion channel activity
U723_RS00110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
U723_RS00115	COG2226	methyltransferase
U723_RS00215	COG0583	DNA-binding transcription factor activity
U723_RS00230	COG3231	kanamycin kinase activity
U723_RS00270	COG0783	Belongs to the Dps family
U723_RS00275	COG1253	flavin adenine dinucleotide binding
U723_RS00280	COG0288	reversible hydration of carbon dioxide
U723_RS00285	COG1609	Transcriptional regulator
U723_RS00310	COG1609	Transcriptional regulator
U723_RS00315	COG3534	alpha-L-arabinofuranosidase
U723_RS00335	COG0656	L-ascorbic acid biosynthetic process
U723_RS00340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
U723_RS00355	COG0180	Tryptophanyl-tRNA synthetase
U723_RS00370	COG0058	SHG alpha-glucan phosphorylase activity
U723_RS00400	COG3764	Sortase (surface protein transpeptidase)
U723_RS00415	COG0515	serine threonine protein kinase
U723_RS00420	COG0768	penicillin binding
U723_RS00450	COG0697	spore germination
U723_RS00465	COG2226	methyltransferase
U723_RS00470	COG2261	transglycosylase associated protein
U723_RS00475	COG2261	transglycosylase associated protein
U723_RS00490	COG2217	Heavy metal translocating P-type atpase
U723_RS00495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U723_RS00510	COG0343	queuine tRNA-ribosyltransferase activity
U723_RS00535	COG2814	Major facilitator Superfamily
U723_RS00550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U723_RS00580	COG0667	Aldo Keto reductase
U723_RS00615	COG1063	alcohol dehydrogenase
U723_RS00620	COG0583	DNA-binding transcription factor activity
U723_RS00630	COG0191	fructose-bisphosphate aldolase activity
U723_RS00640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U723_RS00690	COG2211	Major facilitator Superfamily
U723_RS00700	COG4770	biotin carboxylase activity
U723_RS00730	COG0477	Major facilitator Superfamily
U723_RS00780	COG1132	(ABC) transporter
U723_RS00785	COG0390	transport system, permease component
U723_RS00790	COG1113	amino acid transport
U723_RS00795	COG0577	efflux transmembrane transporter activity
U723_RS00795	COG1136	(ABC) transporter
U723_RS00805	COG1113	amino acid transport
U723_RS00820	COG0577	efflux transmembrane transporter activity
U723_RS00825	COG0577	efflux transmembrane transporter activity
U723_RS00825	COG1136	(ABC) transporter
U723_RS00830	COG1846	Transcriptional regulator
U723_RS00850	COG0671	phosphoesterase, PA-phosphatase related
U723_RS00855	COG0110	maltose O-acetyltransferase activity
U723_RS00895	COG1129	ABC transporter
U723_RS00930	COG1309	transcriptional regulator
U723_RS00950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
U723_RS00960	COG0305	Participates in initiation and elongation during chromosome replication
U723_RS00965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U723_RS01000	COG0406	alpha-ribazole phosphatase activity
U723_RS01000	COG0494	nUDIX hydrolase
U723_RS01085	COG1260	myo-inositol-1-phosphate synthase
U723_RS01095	COG1754	DNA topoisomerase type I activity
U723_RS01095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U723_RS01155	COG0406	alpha-ribazole phosphatase activity
U723_RS01210	COG0446	pyridine nucleotide-disulphide oxidoreductase
U723_RS01215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
U723_RS01265	COG0436	Aminotransferase
U723_RS01280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
U723_RS01280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
U723_RS01290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
U723_RS01305	COG0742	ribosomal rna small subunit methyltransferase
U723_RS01320	COG1837	Belongs to the UPF0109 family
U723_RS01355	COG0488	(ABC) transporter
U723_RS01365	COG0440	acetolactate synthase activity
U723_RS01405	COG0667	Aldo Keto reductase
U723_RS01470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
U723_RS01490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U723_RS01495	COG1530	ribonuclease E activity
U723_RS01520	COG0436	Aminotransferase
U723_RS01555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
U723_RS01555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
U723_RS01560	COG1268	BioY protein
U723_RS01565	COG4770	biotin carboxylase activity
U723_RS01570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
U723_RS01595	COG0039	L-malate dehydrogenase activity
U723_RS01610	COG1704	LemA family
U723_RS01620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U723_RS01625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U723_RS01645	COG0826	peptidase U32
U723_RS01660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
U723_RS01670	COG3579	cysteine-type endopeptidase activity
U723_RS01675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U723_RS01680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
U723_RS01680	COG2755	lipolytic protein G-D-S-L family
U723_RS01685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U723_RS01690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U723_RS01700	COG0745	RESPONSE REGULATOR receiver
U723_RS01715	COG0581	inorganic phosphate transmembrane transporter activity
U723_RS01725	COG2252	PERMEase
U723_RS01810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
U723_RS01815	COG0531	amino acid
U723_RS01830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U723_RS01840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U723_RS01845	COG1739	Uncharacterized protein family UPF0029
U723_RS01880	COG1012	belongs to the aldehyde dehydrogenase family
U723_RS01880	COG1454	alcohol dehydrogenase
U723_RS01940	COG0255	Belongs to the universal ribosomal protein uL29 family
U723_RS02070	COG0196	riboflavin kinase activity
U723_RS02090	COG0328	RNA-DNA hybrid ribonuclease activity
U723_RS02105	COG1597	lipid kinase activity
U723_RS02105	COG1803	Methylglyoxal synthase
U723_RS02130	COG2197	response regulator
U723_RS02150	COG0626	cystathionine gamma-synthase activity
U723_RS02160	COG2873	o-acetylhomoserine
U723_RS02170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U723_RS02185	COG3579	cysteine-type endopeptidase activity
U723_RS02190	COG0531	amino acid
U723_RS02200	COG1113	amino acid transport
U723_RS02215	COG4716	Myosin-crossreactive antigen
U723_RS02220	COG1063	alcohol dehydrogenase
U723_RS02225	COG3321	synthase
U723_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
U723_RS02225	COG0604	alcohol dehydrogenase
U723_RS02235	COG5002	protein histidine kinase activity
U723_RS02240	COG0704	Plays a role in the regulation of phosphate uptake
U723_RS02245	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
U723_RS02250	COG1705	Flagellar rod assembly protein muramidase FlgJ
U723_RS02250	COG3942	CHAP domain
U723_RS02255	COG1388	LysM domain
U723_RS02255	COG0791	NLP P60 protein
U723_RS02275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U723_RS02280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U723_RS02285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U723_RS02360	COG3189	MarR family transcriptional regulator
U723_RS02370	COG3250	beta-galactosidase activity
U723_RS02375	COG1609	Transcriptional regulator
U723_RS02410	COG0395	ABC-type sugar transport system, permease component
U723_RS02440	COG1216	Glycosyl transferase, family 2
U723_RS02445	COG0628	permease
U723_RS02480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U723_RS02495	COG1946	Acyl-CoA thioesterase
U723_RS02505	COG0242	peptide deformylase activity
U723_RS02510	COG2873	o-acetylhomoserine
U723_RS02545	COG3507	Belongs to the glycosyl hydrolase 43 family
U723_RS02560	COG1175	transmembrane transport
U723_RS02570	COG3507	Belongs to the glycosyl hydrolase 43 family
U723_RS02580	COG2272	Belongs to the type-B carboxylesterase lipase family
U723_RS02590	COG1070	Carbohydrate kinase
U723_RS02595	COG1940	carbohydrate kinase activity
U723_RS02615	COG0009	L-threonylcarbamoyladenylate synthase
U723_RS02635	COG0561	phosphatase activity
U723_RS02640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U723_RS02660	COG3590	peptidase
U723_RS02670	COG0024	Methionine aminopeptidase
U723_RS02675	COG0372	Belongs to the citrate synthase family
U723_RS02690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
U723_RS02695	COG2884	Cell division ATP-binding protein ftsE
U723_RS02705	COG1388	LysM domain
U723_RS02705	COG3942	CHAP domain
U723_RS02725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U723_RS02730	COG0765	amino acid transport
U723_RS02745	COG0784	Response regulator, receiver
U723_RS02745	COG2198	Histidine kinase
U723_RS02745	COG2205	protein histidine kinase activity
U723_RS02745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U723_RS02750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U723_RS02770	COG0747	negative chemotaxis
U723_RS02775	COG0601	transmembrane transport
U723_RS02780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U723_RS02790	COG4172	Belongs to the ABC transporter superfamily
U723_RS02805	COG0514	ATP-dependent DNA helicase (RecQ)
U723_RS02885	COG0371	Dehydrogenase
U723_RS02900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U723_RS02905	COG0358	DNA primase activity
U723_RS02910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U723_RS02920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
U723_RS02925	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
U723_RS02930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
U723_RS02935	COG0735	belongs to the Fur family
U723_RS02940	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
U723_RS02945	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
U723_RS02950	COG0151	Belongs to the GarS family
U723_RS02965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U723_RS03020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
U723_RS03100	COG0284	orotidine-5'-phosphate decarboxylase activity
U723_RS03125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
U723_RS03140	COG0560	Phosphoserine phosphatase
U723_RS03145	COG0586	Pfam SNARE associated Golgi protein
U723_RS03155	COG4122	O-methyltransferase activity
U723_RS03185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
U723_RS03225	COG0714	Associated with various cellular activities
U723_RS03240	COG1278	Cold shock
U723_RS03260	COG0745	RESPONSE REGULATOR receiver
U723_RS03265	COG2205	protein histidine kinase activity
U723_RS03270	COG1278	Cold shock
U723_RS03305	COG1196	nuclear chromosome segregation
U723_RS03315	COG1126	abc transporter atp-binding protein
U723_RS03320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U723_RS03325	COG0765	amino acid transport
U723_RS03330	COG0765	amino acid transport
U723_RS03335	COG2326	polyphosphate kinase activity
U723_RS03350	COG2814	Major facilitator Superfamily
U723_RS03355	COG1022	Amp-dependent synthetase and ligase
U723_RS03360	COG3328	transposase activity
U723_RS03385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
U723_RS03395	COG0656	L-ascorbic acid biosynthetic process
U723_RS03420	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
U723_RS03440	COG2151	metal-sulfur cluster biosynthetic enzyme
U723_RS03440	COG0489	protein tyrosine kinase activity
U723_RS03445	COG4721	ABC-type cobalt transport system, permease component
U723_RS03470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U723_RS03495	COG1136	(ABC) transporter
U723_RS03500	COG4721	ABC-type cobalt transport system, permease component
U723_RS03505	COG4172	Belongs to the ABC transporter superfamily
U723_RS03510	COG1136	(ABC) transporter
U723_RS03515	COG0577	efflux transmembrane transporter activity
U723_RS03525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U723_RS03615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U723_RS03620	COG0569	domain protein
U723_RS03635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U723_RS03655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
U723_RS03675	COG0799	negative regulation of ribosome biogenesis
U723_RS03705	COG0406	alpha-ribazole phosphatase activity
U723_RS03710	COG0598	Magnesium transport protein CorA
U723_RS03740	COG0802	atpase or kinase
U723_RS03795	COG0516	GMP reductase activity
U723_RS03835	COG0575	Belongs to the CDS family
U723_RS03875	COG1573	uracil-dna glycosylase
U723_RS03885	COG0133	tryptophan synthase activity
U723_RS03900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U723_RS03915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U723_RS03935	COG1716	ATPase activity
U723_RS03950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U723_RS03955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U723_RS04005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U723_RS04025	COG0045	succinate-CoA ligase (ADP-forming) activity
U723_RS04060	COG0438	transferase activity, transferring glycosyl groups
U723_RS04065	COG1560	Kdo2-lipid A biosynthetic process
U723_RS04080	COG0488	(ABC) transporter
U723_RS04090	COG0456	acetyltransferase
U723_RS04160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U723_RS04170	COG0436	Aminotransferase
U723_RS04180	COG0436	Aminotransferase
U723_RS04185	COG0561	phosphatase activity
U723_RS04190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U723_RS04215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
U723_RS04250	COG0488	(ABC) transporter
U723_RS04275	COG0450	alkyl hydroperoxide reductase
U723_RS04285	COG0583	DNA-binding transcription factor activity
U723_RS04325	COG0167	dihydroorotate dehydrogenase activity
U723_RS04335	COG0284	orotidine-5'-phosphate decarboxylase activity
U723_RS04340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
U723_RS04385	COG1119	ATPase activity
U723_RS04390	COG0297	glycogen (starch) synthase activity
U723_RS04410	COG0070	glutamate synthase
U723_RS04410	COG0069	glutamate synthase activity
U723_RS04410	COG0067	glutamate synthase
U723_RS04430	COG2860	membrane
U723_RS04435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U723_RS04460	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
U723_RS04485	COG1702	phosphate starvation-inducible protein PhoH
U723_RS04490	COG0537	adenosine 5'-monophosphoramidase activity
U723_RS04495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
U723_RS04520	COG2151	metal-sulfur cluster biosynthetic enzyme
U723_RS04525	COG0822	iron-sulfur transferase activity
U723_RS04535	COG0396	ATPase activity
U723_RS04540	COG0719	Fe-S assembly protein
U723_RS04550	COG1376	ErfK ybiS ycfS ynhG family protein
U723_RS04565	COG1523	belongs to the glycosyl hydrolase 13 family
U723_RS04610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
U723_RS04655	COG0588	phosphoglycerate mutase activity
U723_RS04660	COG1950	PFAM Membrane protein of
U723_RS04695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
U723_RS04710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
U723_RS04725	COG1131	(ABC) transporter
U723_RS04730	COG1725	Transcriptional regulator
U723_RS04740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
U723_RS04765	COG0563	adenylate kinase activity
U723_RS04785	COG3039	Transposase
U723_RS04805	COG0857	belongs to the CobB CobQ family
U723_RS04805	COG0280	phosphate acetyltransferase
U723_RS04810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
U723_RS04840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
U723_RS04855	COG0494	nUDIX hydrolase
U723_RS04865	COG0469	pyruvate kinase activity
U723_RS04880	COG0237	dephospho-CoA kinase activity
U723_RS04885	COG0539	negative regulation of cytoplasmic translation
U723_RS04895	COG0803	Belongs to the bacterial solute-binding protein 9 family
U723_RS04900	COG1121	(ABC) transporter
U723_RS04915	COG1329	Transcriptional regulator
U723_RS04925	COG0745	RESPONSE REGULATOR receiver
U723_RS04930	COG2205	protein histidine kinase activity
U723_RS04960	COG1316	TRANSCRIPTIONal
U723_RS04965	COG1316	TRANSCRIPTIONal
U723_RS04990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U723_RS05000	COG1760	l-serine dehydratase
U723_RS05045	COG1116	anion transmembrane transporter activity
U723_RS05070	COG1472	Belongs to the glycosyl hydrolase 3 family
U723_RS05080	COG1966	Carbon starvation protein
U723_RS05085	COG1132	(ABC) transporter
U723_RS05090	COG1132	(ABC) transporter
U723_RS05125	COG1918	ferrous iron import across plasma membrane
U723_RS05125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
U723_RS05145	COG0363	glucosamine-6-phosphate deaminase activity
U723_RS05150	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
U723_RS05155	COG3340	Belongs to the peptidase S51 family
U723_RS05160	COG1114	Component of the transport system for branched-chain amino acids
U723_RS05190	COG2233	PERMEase
U723_RS05210	COG0012	GTP binding
U723_RS05215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U723_RS05225	COG4585	Histidine kinase
U723_RS05230	COG2197	response regulator
U723_RS05240	COG0577	efflux transmembrane transporter activity
U723_RS05240	COG1136	(ABC) transporter
U723_RS05250	COG1122	ATPase activity
U723_RS05255	COG2873	o-acetylhomoserine
U723_RS05285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U723_RS05350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U723_RS05355	COG1882	Formate acetyltransferase
U723_RS05370	COG1473	amidohydrolase
U723_RS05375	COG2011	ABC-type metal ion transport system permease component
U723_RS05385	COG1464	Belongs to the NlpA lipoprotein family
U723_RS05390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U723_RS05395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U723_RS05420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U723_RS05425	COG4975	Glucose uptake
U723_RS05430	COG1201	RNA secondary structure unwinding
U723_RS05455	COG0187	DNA topoisomerase II activity
U723_RS05460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U723_RS05470	COG0142	geranyltranstransferase activity
U723_RS05490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U723_RS05500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
U723_RS05520	COG1396	sequence-specific DNA binding
U723_RS05530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U723_RS05550	COG2357	RelA SpoT domain protein
U723_RS05555	COG0670	Belongs to the BI1 family
U723_RS05560	COG3804	dihydrodipicolinate reductase
U723_RS05575	COG1131	(ABC) transporter
U723_RS05580	COG4585	Histidine kinase
U723_RS05585	COG2197	response regulator
U723_RS05605	COG0110	maltose O-acetyltransferase activity
U723_RS05615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
U723_RS05645	COG0708	Exodeoxyribonuclease III
U723_RS05660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U723_RS05665	COG0601	transmembrane transport
U723_RS05670	COG4166	transmembrane transport
U723_RS05680	COG1136	(ABC) transporter
U723_RS05685	COG0577	efflux transmembrane transporter activity
U723_RS05695	COG0287	Prephenate dehydrogenase
U723_RS05710	COG1217	gtp-binding protein TYPA
U723_RS05715	COG0477	Major facilitator Superfamily
U723_RS05745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
U723_RS05760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U723_RS05770	COG2017	converts alpha-aldose to the beta-anomer
U723_RS05795	COG0285	dihydrofolate synthase activity
U723_RS05815	COG0006	proline dipeptidase activity
U723_RS05820	COG2816	NAD+ diphosphatase activity
U723_RS05840	COG0582	viral genome integration into host DNA
U723_RS05920	COG0601	transmembrane transport
U723_RS05965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U723_RS05975	COG0768	penicillin binding
U723_RS06000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U723_RS06020	COG1230	cation diffusion facilitator family transporter
U723_RS06030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
U723_RS06040	COG1643	Atp-dependent helicase
U723_RS06085	COG0587	DNA-directed DNA polymerase activity
U723_RS06120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
U723_RS06125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U723_RS06165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U723_RS06170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U723_RS06175	COG1957	nucleoside hydrolase
U723_RS06230	COG3480	Lon protease (S16) C-terminal proteolytic domain
U723_RS06255	COG0613	PHP domain protein
U723_RS06265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
U723_RS06290	COG1126	abc transporter atp-binding protein
U723_RS06295	COG0765	amino acid transport
U723_RS06300	COG0765	amino acid transport
U723_RS06305	COG0436	Aminotransferase
U723_RS06310	COG2011	ABC-type metal ion transport system permease component
U723_RS06320	COG1464	Belongs to the NlpA lipoprotein family
U723_RS06325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U723_RS06385	COG4166	transmembrane transport
U723_RS06390	COG2814	Major facilitator Superfamily
U723_RS06395	COG1842	Phage shock protein A
U723_RS06415	COG2365	Tyrosine phosphatase family
U723_RS06430	COG1132	(ABC) transporter
U723_RS06435	COG1132	(ABC) transporter
U723_RS06480	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
U723_RS06485	COG1468	defense response to virus
U723_RS06485	COG1518	maintenance of DNA repeat elements
U723_RS06520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
U723_RS06520	COG1328	CTP reductase activity
U723_RS06525	COG1570	exodeoxyribonuclease VII activity
U723_RS06530	COG1722	exodeoxyribonuclease VII activity
U723_RS06550	COG0436	Aminotransferase
U723_RS06585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
U723_RS06610	COG0210	DNA helicase
U723_RS06630	COG0714	Associated with various cellular activities
U723_RS06670	COG1194	a g-specific adenine glycosylase
U723_RS06675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
U723_RS06695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
U723_RS06705	COG1349	DNA-binding transcription factor activity
U723_RS06710	COG1216	Glycosyl transferase, family 2
U723_RS06715	COG0167	dihydroorotate dehydrogenase activity
U723_RS06720	COG1902	pentaerythritol trinitrate reductase activity
U723_RS06725	COG4499	WXG100 protein secretion system (Wss), protein YukC
U723_RS06725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U723_RS06735	COG0095	Lipoate-protein ligase
U723_RS06780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U723_RS06815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
U723_RS06825	COG1088	dTDP-glucose 4,6-dehydratase activity
U723_RS06845	COG1216	Glycosyl transferase, family 2
U723_RS06845	COG1442	glycosyl transferase family 8
U723_RS06895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
U723_RS06905	COG2814	Major facilitator Superfamily
U723_RS06960	COG4988	ABC transporter
U723_RS06975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U723_RS06985	COG0489	protein tyrosine kinase activity
U723_RS07005	COG0083	homoserine kinase activity
U723_RS07010	COG0460	homoserine dehydrogenase
U723_RS07015	COG0019	diaminopimelate decarboxylase activity
U723_RS07030	COG0251	oxidation-reduction process
U723_RS07035	COG0395	ABC-type sugar transport system, permease component
U723_RS07040	COG3459	Glycosyltransferase 36 associated
U723_RS07065	COG0545	Peptidyl-prolyl cis-trans isomerase
U723_RS07075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
U723_RS07110	COG0356	it plays a direct role in the translocation of protons across the membrane
U723_RS07120	COG0477	Major facilitator Superfamily
U723_RS07175	COG0582	viral genome integration into host DNA
U723_RS07190	COG0679	Auxin Efflux Carrier
U723_RS07195	COG0028	Belongs to the TPP enzyme family
U723_RS07220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
U723_RS07230	COG0745	RESPONSE REGULATOR receiver
U723_RS07240	COG0747	negative chemotaxis
U723_RS07255	COG0287	Prephenate dehydrogenase
U723_RS07255	COG1605	Chorismate mutase
U723_RS07320	COG2217	Heavy metal translocating P-type atpase
U723_RS07330	COG0179	Fumarylacetoacetate (FAA) hydrolase
U723_RS07355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
U723_RS07370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U723_RS07420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U723_RS07435	COG1609	Transcriptional regulator
U723_RS07490	COG1368	sulfuric ester hydrolase activity
U723_RS07495	COG1368	sulfuric ester hydrolase activity
U723_RS07500	COG1216	Glycosyl transferase, family 2
U723_RS07550	COG1216	Glycosyl transferase, family 2
U723_RS07600	COG0084	hydrolase, TatD family'
U723_RS07615	COG1132	(ABC) transporter
U723_RS07620	COG1132	(ABC) transporter
U723_RS07655	COG0586	Pfam SNARE associated Golgi protein
U723_RS07675	COG1309	transcriptional regulator
U723_RS07680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U723_RS07685	COG0789	Transcriptional regulator
U723_RS07690	COG0484	heat shock protein binding
U723_RS07720	COG1523	belongs to the glycosyl hydrolase 13 family
U723_RS07725	COG3833	ABC-type maltose transport systems, permease component
U723_RS07730	COG1175	transmembrane transport
U723_RS07740	COG0366	Alpha amylase catalytic
U723_RS07765	COG1609	Transcriptional regulator
U723_RS07775	COG0366	Alpha amylase catalytic
U723_RS07790	COG0778	Nitroreductase
U723_RS07800	COG2814	Major facilitator Superfamily
U723_RS07850	COG1609	Transcriptional regulator
U723_RS07855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
U723_RS07860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U723_RS07865	COG0366	Alpha amylase catalytic
U723_RS07880	COG0395	ABC-type sugar transport system, permease component
U723_RS07885	COG1175	transmembrane transport
U723_RS07905	COG0037	tRNA processing
U723_RS07905	COG0590	tRNA wobble adenosine to inosine editing
U723_RS07910	COG0025	NhaP-type Na H and K H
U723_RS07930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U723_RS07935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U723_RS07945	COG3842	ATPase activity
U723_RS07950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U723_RS07970	COG3583	domain protein
U723_RS07990	COG0617	tRNA 3'-terminal CCA addition
U723_RS08010	COG0492	ferredoxin-NADP+ reductase activity
U723_RS08015	COG1475	DNA binding
U723_RS08020	COG1192	Involved in chromosome partitioning
U723_RS08030	COG1847	R3H domain protein