locus-tag	class	description
RY70_RS00020	COG3231	kanamycin kinase activity
RY70_RS00040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RY70_RS00045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RY70_RS00050	COG0590	tRNA wobble adenosine to inosine editing
RY70_RS00050	COG0037	tRNA processing
RY70_RS00060	COG0025	NhaP-type Na H and K H
RY70_RS00075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RY70_RS00080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RY70_RS00110	COG2826	transposase and inactivated derivatives, IS30 family
RY70_RS00115	COG3842	ATPase activity
RY70_RS00140	COG3583	domain protein
RY70_RS00160	COG0617	tRNA 3'-terminal CCA addition
RY70_RS00180	COG0492	ferredoxin-NADP+ reductase activity
RY70_RS00190	COG1192	Involved in chromosome partitioning
RY70_RS00200	COG1847	R3H domain protein
RY70_RS00225	COG0592	DNA-directed DNA polymerase activity
RY70_RS00240	COG0187	DNA topoisomerase II activity
RY70_RS00245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RY70_RS00300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RY70_RS00310	COG1970	mechanosensitive ion channel activity
RY70_RS00315	COG3534	alpha-L-arabinofuranosidase
RY70_RS00340	COG1609	Transcriptional regulator
RY70_RS00345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY70_RS00365	COG0783	Belongs to the Dps family
RY70_RS00375	COG1253	flavin adenine dinucleotide binding
RY70_RS00385	COG0288	reversible hydration of carbon dioxide
RY70_RS00410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RY70_RS00430	COG0180	Tryptophanyl-tRNA synthetase
RY70_RS00450	COG1088	dTDP-glucose 4,6-dehydratase activity
RY70_RS00485	COG1442	glycosyl transferase family 8
RY70_RS00500	COG1484	DNA-dependent DNA replication
RY70_RS00510	COG1404	Belongs to the peptidase S8 family
RY70_RS00525	COG1442	glycosyl transferase family 8
RY70_RS00575	COG3328	transposase activity
RY70_RS00590	COG1088	dTDP-glucose 4,6-dehydratase activity
RY70_RS00600	COG1309	transcriptional regulator
RY70_RS00610	COG2814	Major facilitator Superfamily
RY70_RS00615	COG2801	Transposase and inactivated derivatives
RY70_RS00640	COG0058	SHG alpha-glucan phosphorylase activity
RY70_RS00690	COG0515	serine threonine protein kinase
RY70_RS00695	COG0768	penicillin binding
RY70_RS00755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RY70_RS00755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RY70_RS00765	COG0513	Belongs to the DEAD box helicase family
RY70_RS00770	COG0494	nUDIX hydrolase
RY70_RS00800	COG2801	Transposase and inactivated derivatives
RY70_RS00840	COG0343	queuine tRNA-ribosyltransferase activity
RY70_RS00915	COG0191	fructose-bisphosphate aldolase activity
RY70_RS00950	COG0477	Major facilitator Superfamily
RY70_RS00970	COG3250	beta-galactosidase activity
RY70_RS00975	COG1113	amino acid transport
RY70_RS00990	COG1136	(ABC) transporter
RY70_RS00990	COG0577	efflux transmembrane transporter activity
RY70_RS01065	COG0477	Major facilitator Superfamily
RY70_RS01075	COG2801	Transposase and inactivated derivatives
RY70_RS01110	COG0667	Aldo Keto reductase
RY70_RS01120	COG1846	Transcriptional regulator
RY70_RS01130	COG1132	(ABC) transporter
RY70_RS01180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RY70_RS01190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY70_RS01240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RY70_RS01255	COG0167	dihydroorotate dehydrogenase activity
RY70_RS01260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RY70_RS01270	COG1309	transcriptional regulator
RY70_RS01330	COG4948	Mandelate Racemase Muconate Lactonizing
RY70_RS01330	COG4948	Mandelate Racemase Muconate Lactonizing
RY70_RS01350	COG0251	oxidation-reduction process
RY70_RS01355	COG0584	glycerophosphoryl diester phosphodiesterase
RY70_RS01370	COG2190	(PTS) system
RY70_RS01370	COG1263	PTS System
RY70_RS01370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY70_RS01375	COG2190	(PTS) system
RY70_RS01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY70_RS01375	COG1263	PTS System
RY70_RS01380	COG0460	homoserine dehydrogenase
RY70_RS01385	COG0083	homoserine kinase activity
RY70_RS01405	COG1136	(ABC) transporter
RY70_RS01420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RY70_RS01425	COG1530	ribonuclease E activity
RY70_RS01455	COG0436	Aminotransferase
RY70_RS01465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RY70_RS01490	COG0584	glycerophosphoryl diester phosphodiesterase
RY70_RS01495	COG0366	Alpha amylase catalytic
RY70_RS01560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RY70_RS01605	COG0179	Fumarylacetoacetate (FAA) hydrolase
RY70_RS01635	COG0436	Aminotransferase
RY70_RS01660	COG1022	Amp-dependent synthetase and ligase
RY70_RS01745	COG0789	Transcriptional regulator
RY70_RS01750	COG2270	Major facilitator Superfamily
RY70_RS01790	COG1301	dicarboxylic acid transport
RY70_RS01795	COG0742	ribosomal rna small subunit methyltransferase
RY70_RS01805	COG0071	Belongs to the small heat shock protein (HSP20) family
RY70_RS01820	COG1837	Belongs to the UPF0109 family
RY70_RS01830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RY70_RS01860	COG0519	Catalyzes the synthesis of GMP from XMP
RY70_RS01865	COG0488	(ABC) transporter
RY70_RS01905	COG0440	acetolactate synthase activity
RY70_RS01955	COG1116	anion transmembrane transporter activity
RY70_RS01970	COG3775	system Galactitol-specific IIC component
RY70_RS02000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RY70_RS02005	COG1609	Transcriptional regulator
RY70_RS02035	COG1609	Transcriptional regulator
RY70_RS02040	COG0656	L-ascorbic acid biosynthetic process
RY70_RS02055	COG2814	Major facilitator Superfamily
RY70_RS02070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RY70_RS02115	COG0095	Lipoate-protein ligase
RY70_RS02120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RY70_RS02125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RY70_RS02125	COG4499	WXG100 protein secretion system (Wss), protein YukC
RY70_RS02130	COG1902	pentaerythritol trinitrate reductase activity
RY70_RS02135	COG0167	dihydroorotate dehydrogenase activity
RY70_RS02140	COG1349	DNA-binding transcription factor activity
RY70_RS02150	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RY70_RS02155	COG0477	Major facilitator Superfamily
RY70_RS02180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RY70_RS02240	COG0714	Associated with various cellular activities
RY70_RS02250	COG2815	serine threonine protein kinase
RY70_RS02250	COG0515	serine threonine protein kinase
RY70_RS02305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RY70_RS02315	COG1404	Belongs to the peptidase S8 family
RY70_RS02340	COG0436	Aminotransferase
RY70_RS02345	COG0248	Ppx GppA phosphatase
RY70_RS02360	COG2210	Belongs to the sulfur carrier protein TusA family
RY70_RS02380	COG1722	exodeoxyribonuclease VII activity
RY70_RS02385	COG1570	exodeoxyribonuclease VII activity
RY70_RS02390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RY70_RS02390	COG1328	CTP reductase activity
RY70_RS02395	COG0602	queuosine metabolic process
RY70_RS02430	COG1132	(ABC) transporter
RY70_RS02435	COG1132	(ABC) transporter
RY70_RS02450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RY70_RS02460	COG0613	PHP domain protein
RY70_RS02485	COG3480	Lon protease (S16) C-terminal proteolytic domain
RY70_RS02505	COG0351	phosphomethylpyrimidine kinase
RY70_RS02510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RY70_RS02530	COG3250	beta-galactosidase activity
RY70_RS02545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RY70_RS02590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RY70_RS02595	COG2884	Cell division ATP-binding protein ftsE
RY70_RS02600	COG2177	Part of the ABC transporter FtsEX involved in
RY70_RS02605	COG3942	CHAP domain
RY70_RS02605	COG1705	Flagellar rod assembly protein muramidase FlgJ
RY70_RS02615	COG0564	pseudouridine synthase activity
RY70_RS02670	COG3878	Protein conserved in bacteria
RY70_RS02675	COG1621	beta-fructofuranosidase activity
RY70_RS02680	COG0587	DNA-directed DNA polymerase activity
RY70_RS02695	COG4716	Myosin-crossreactive antigen
RY70_RS02700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RY70_RS02710	COG0656	L-ascorbic acid biosynthetic process
RY70_RS02795	COG1643	Atp-dependent helicase
RY70_RS02810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RY70_RS02840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY70_RS02865	COG0768	penicillin binding
RY70_RS02875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RY70_RS02960	COG0601	transmembrane transport
RY70_RS02965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RY70_RS02975	COG0006	proline dipeptidase activity
RY70_RS02985	COG0285	dihydrofolate synthase activity
RY70_RS02990	COG1196	nuclear chromosome segregation
RY70_RS02995	COG1794	racemase activity, acting on amino acids and derivatives
RY70_RS03020	COG1595	DNA-templated transcription, initiation
RY70_RS03040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RY70_RS03060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RY70_RS03090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RY70_RS03100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RY70_RS03105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RY70_RS03115	COG1104	cysteine desulfurase activity
RY70_RS03120	COG1217	gtp-binding protein TYPA
RY70_RS03135	COG0287	Prephenate dehydrogenase
RY70_RS03175	COG0708	Exodeoxyribonuclease III
RY70_RS03235	COG1011	Hydrolase
RY70_RS03245	COG0560	Phosphoserine phosphatase
RY70_RS03250	COG1222	aaa ATPase
RY70_RS03255	COG4122	O-methyltransferase activity
RY70_RS03285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RY70_RS03325	COG0714	Associated with various cellular activities
RY70_RS03340	COG1278	Cold shock
RY70_RS03360	COG0745	RESPONSE REGULATOR receiver
RY70_RS03365	COG2205	protein histidine kinase activity
RY70_RS03370	COG1278	Cold shock
RY70_RS03405	COG1196	nuclear chromosome segregation
RY70_RS03430	COG1126	abc transporter atp-binding protein
RY70_RS03435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY70_RS03440	COG0765	amino acid transport
RY70_RS03445	COG0765	amino acid transport
RY70_RS03450	COG2326	polyphosphate kinase activity
RY70_RS03465	COG2814	Major facilitator Superfamily
RY70_RS03490	COG1122	ATPase activity
RY70_RS03525	COG0582	viral genome integration into host DNA
RY70_RS03580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RY70_RS03600	COG1136	(ABC) transporter
RY70_RS03625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RY70_RS03655	COG1682	transport, permease protein
RY70_RS03660	COG1134	teichoic acid transport
RY70_RS03680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RY70_RS03685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RY70_RS03720	COG1760	l-serine dehydratase
RY70_RS03730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RY70_RS03755	COG1674	ftsk spoiiie
RY70_RS03760	COG1316	TRANSCRIPTIONal
RY70_RS03790	COG1040	competence protein
RY70_RS03800	COG2205	protein histidine kinase activity
RY70_RS03805	COG0745	RESPONSE REGULATOR receiver
RY70_RS03830	COG1121	(ABC) transporter
RY70_RS03845	COG0539	negative regulation of cytoplasmic translation
RY70_RS03865	COG0469	pyruvate kinase activity
RY70_RS03870	COG0494	nUDIX hydrolase
RY70_RS03890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RY70_RS03895	COG0494	nUDIX hydrolase
RY70_RS03945	COG0693	protein deglycase activity
RY70_RS03960	COG3340	Belongs to the peptidase S51 family
RY70_RS03970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RY70_RS03975	COG0857	belongs to the CobB CobQ family
RY70_RS03975	COG0280	phosphate acetyltransferase
RY70_RS03990	COG0306	phosphate transporter
RY70_RS04000	COG2197	response regulator
RY70_RS04005	COG4585	Histidine kinase
RY70_RS04015	COG1131	(ABC) transporter
RY70_RS04035	COG2826	transposase and inactivated derivatives, IS30 family
RY70_RS04060	COG2801	Transposase and inactivated derivatives
RY70_RS04075	COG1335	isochorismatase
RY70_RS04085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RY70_RS04110	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RY70_RS04110	COG2755	lipolytic protein G-D-S-L family
RY70_RS04140	COG2755	lipolytic protein G-D-S-L family
RY70_RS04140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RY70_RS04190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RY70_RS04220	COG0719	Fe-S assembly protein
RY70_RS04225	COG0396	ATPase activity
RY70_RS04240	COG2151	metal-sulfur cluster biosynthetic enzyme
RY70_RS04260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RY70_RS04265	COG0537	adenosine 5'-monophosphoramidase activity
RY70_RS04295	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RY70_RS04320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RY70_RS04335	COG2860	membrane
RY70_RS04355	COG0436	Aminotransferase
RY70_RS04365	COG0070	glutamate synthase
RY70_RS04365	COG0069	glutamate synthase activity
RY70_RS04365	COG0067	glutamate synthase
RY70_RS04380	COG0297	glycogen (starch) synthase activity
RY70_RS04385	COG1119	ATPase activity
RY70_RS04390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RY70_RS04465	COG2962	Rard protein
RY70_RS04475	COG1073	alpha beta
RY70_RS04485	COG2062	phosphohistidine phosphatase, SixA
RY70_RS04495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RY70_RS04520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RY70_RS04525	COG0284	orotidine-5'-phosphate decarboxylase activity
RY70_RS04530	COG0543	2 iron, 2 sulfur cluster binding
RY70_RS04535	COG0167	dihydroorotate dehydrogenase activity
RY70_RS04550	COG1063	alcohol dehydrogenase
RY70_RS04570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RY70_RS04580	COG4221	oxidoreductase activity
RY70_RS04615	COG4106	trans-aconitate 2-methyltransferase activity
RY70_RS04625	COG3226	Transcriptional regulator
RY70_RS04635	COG0583	DNA-binding transcription factor activity
RY70_RS04765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RY70_RS04780	COG0133	tryptophan synthase activity
RY70_RS04795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RY70_RS04820	COG0045	succinate-CoA ligase (ADP-forming) activity
RY70_RS04830	COG1862	Preprotein translocase
RY70_RS04865	COG1301	dicarboxylic acid transport
RY70_RS04930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RY70_RS04935	COG3619	membrane
RY70_RS04960	COG0561	phosphatase activity
RY70_RS04970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RY70_RS04995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RY70_RS05020	COG0745	RESPONSE REGULATOR receiver
RY70_RS05025	COG2205	protein histidine kinase activity
RY70_RS05030	COG1876	peptidase activity
RY70_RS05035	COG0488	(ABC) transporter
RY70_RS05055	COG1940	carbohydrate kinase activity
RY70_RS05060	COG1940	carbohydrate kinase activity
RY70_RS05070	COG0395	ABC-type sugar transport system, permease component
RY70_RS05075	COG1175	transmembrane transport
RY70_RS05155	COG0516	GMP reductase activity
RY70_RS05170	COG1022	Amp-dependent synthetase and ligase
RY70_RS05190	COG0456	acetyltransferase
RY70_RS05200	COG0802	atpase or kinase
RY70_RS05225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY70_RS05235	COG0406	alpha-ribazole phosphatase activity
RY70_RS05265	COG3189	MarR family transcriptional regulator
RY70_RS05285	COG1051	belongs to the nudix hydrolase family
RY70_RS05320	COG2135	peptidase activity
RY70_RS05360	COG2249	NAD(P)H dehydrogenase (quinone) activity
RY70_RS05435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RY70_RS05465	COG1131	(ABC) transporter
RY70_RS05470	COG2186	Transcriptional regulator
RY70_RS05475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY70_RS05480	COG0497	DNA recombination
RY70_RS05495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RY70_RS05500	COG0569	domain protein
RY70_RS05515	COG0647	UMP catabolic process
RY70_RS05615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RY70_RS05620	COG1136	(ABC) transporter
RY70_RS05625	COG0390	transport system, permease component
RY70_RS05640	COG2233	PERMEase
RY70_RS05660	COG0583	DNA-binding transcription factor activity
RY70_RS05675	COG1442	glycosyl transferase family 8
RY70_RS05675	COG1216	Glycosyl transferase, family 2
RY70_RS05700	COG0242	peptide deformylase activity
RY70_RS05765	COG3177	Filamentation induced by cAMP protein fic
RY70_RS05770	COG0012	GTP binding
RY70_RS05775	COG0436	Aminotransferase
RY70_RS05785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RY70_RS05790	COG0508	dehydrogenase complex catalyzes the overall conversion of
RY70_RS05790	COG0022	dehydrogenase e1 component
RY70_RS05795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RY70_RS05810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RY70_RS05825	COG2197	response regulator
RY70_RS05830	COG0671	phosphoesterase, PA-phosphatase related
RY70_RS05835	COG1136	(ABC) transporter
RY70_RS05835	COG0577	efflux transmembrane transporter activity
RY70_RS05840	COG1136	(ABC) transporter
RY70_RS05860	COG2873	o-acetylhomoserine
RY70_RS05875	COG1053	succinate dehydrogenase
RY70_RS05910	COG1611	Belongs to the LOG family
RY70_RS05915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RY70_RS05920	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RY70_RS05990	COG1882	Formate acetyltransferase
RY70_RS06005	COG1473	amidohydrolase
RY70_RS06015	COG0561	phosphatase activity
RY70_RS06060	COG0489	protein tyrosine kinase activity
RY70_RS06095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RY70_RS06095	COG0551	DNA topoisomerase type I activity
RY70_RS06120	COG3843	relaxase mobilization nuclease domain protein
RY70_RS06190	COG0739	heme binding
RY70_RS06190	COG1196	nuclear chromosome segregation
RY70_RS06190	COG0741	lytic transglycosylase activity
RY70_RS06230	COG2217	Heavy metal translocating P-type atpase
RY70_RS06290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RY70_RS06315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RY70_RS06320	COG1201	RNA secondary structure unwinding
RY70_RS06325	COG3655	Transcriptional regulator
RY70_RS06335	COG1027	Aspartate ammonia-lyase
RY70_RS06340	COG0187	DNA topoisomerase II activity
RY70_RS06345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RY70_RS06355	COG0142	geranyltranstransferase activity
RY70_RS06375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RY70_RS06385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RY70_RS06410	COG1396	sequence-specific DNA binding
RY70_RS06415	COG1546	Belongs to the CinA family
RY70_RS06415	COG1058	Belongs to the CinA family
RY70_RS06420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RY70_RS06445	COG2357	RelA SpoT domain protein
RY70_RS06455	COG0670	Belongs to the BI1 family
RY70_RS06470	COG2197	response regulator
RY70_RS06480	COG0284	orotidine-5'-phosphate decarboxylase activity
RY70_RS06545	COG2873	o-acetylhomoserine
RY70_RS06605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RY70_RS06625	COG1368	sulfuric ester hydrolase activity
RY70_RS06630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RY70_RS06635	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RY70_RS06650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RY70_RS06655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RY70_RS06665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RY70_RS06675	COG0701	Predicted permease
RY70_RS06695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RY70_RS06700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RY70_RS06710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RY70_RS06720	COG1355	regulation of microtubule-based process
RY70_RS06730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RY70_RS06745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RY70_RS06750	COG0531	amino acid
RY70_RS06765	COG0514	ATP-dependent DNA helicase (RecQ)
RY70_RS06815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RY70_RS06850	COG0395	ABC-type sugar transport system, permease component
RY70_RS06880	COG1950	PFAM Membrane protein of
RY70_RS06885	COG1012	belongs to the aldehyde dehydrogenase family
RY70_RS06905	COG0446	pyridine nucleotide-disulphide oxidoreductase
RY70_RS06910	COG1929	Belongs to the glycerate kinase type-1 family
RY70_RS06915	COG0577	efflux transmembrane transporter activity
RY70_RS06915	COG1136	(ABC) transporter
RY70_RS06920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RY70_RS06935	COG0667	Aldo Keto reductase
RY70_RS06940	COG2176	DNA-directed DNA polymerase activity
RY70_RS06950	COG0024	Methionine aminopeptidase
RY70_RS06960	COG3590	peptidase
RY70_RS06990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RY70_RS07005	COG2205	protein histidine kinase activity
RY70_RS07015	COG0366	Alpha amylase catalytic
RY70_RS07025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RY70_RS07030	COG0009	L-threonylcarbamoyladenylate synthase
RY70_RS07065	COG4975	Glucose uptake
RY70_RS07070	COG0673	inositol 2-dehydrogenase activity
RY70_RS07075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RY70_RS07095	COG0513	Belongs to the DEAD box helicase family
RY70_RS07105	COG0577	efflux transmembrane transporter activity
RY70_RS07125	COG2873	o-acetylhomoserine
RY70_RS07140	COG1940	carbohydrate kinase activity
RY70_RS07145	COG0488	(ABC) transporter
RY70_RS07150	COG0477	Major facilitator Superfamily
RY70_RS07190	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RY70_RS07225	COG1946	Acyl-CoA thioesterase
RY70_RS07235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RY70_RS07240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RY70_RS07250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RY70_RS07255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RY70_RS07280	COG1215	transferase activity, transferring glycosyl groups
RY70_RS07290	COG1216	Glycosyl transferase, family 2
RY70_RS07295	COG1454	alcohol dehydrogenase
RY70_RS07315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RY70_RS07340	COG3250	beta-galactosidase activity
RY70_RS07350	COG1609	Transcriptional regulator
RY70_RS07355	COG2205	protein histidine kinase activity
RY70_RS07360	COG0745	RESPONSE REGULATOR receiver
RY70_RS07375	COG1136	(ABC) transporter
RY70_RS07390	COG0577	efflux transmembrane transporter activity
RY70_RS07400	COG1136	(ABC) transporter
RY70_RS07420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RY70_RS07435	COG0589	response to stress
RY70_RS07445	COG1388	LysM domain
RY70_RS07445	COG3942	CHAP domain
RY70_RS07450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RY70_RS07460	COG5002	protein histidine kinase activity
RY70_RS07465	COG0704	Plays a role in the regulation of phosphate uptake
RY70_RS07485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RY70_RS07495	COG2814	Major facilitator Superfamily
RY70_RS07525	COG2197	response regulator
RY70_RS07530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RY70_RS07535	COG0363	glucosamine-6-phosphate deaminase activity
RY70_RS07575	COG4085	toxin activity
RY70_RS07575	COG1525	nuclease
RY70_RS07575	COG0737	Belongs to the 5'-nucleotidase family
RY70_RS07580	COG1597	lipid kinase activity
RY70_RS07580	COG1803	Methylglyoxal synthase
RY70_RS07585	COG3711	transcriptional antiterminator
RY70_RS07590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY70_RS07590	COG1263	PTS System
RY70_RS07590	COG2190	(PTS) system
RY70_RS07615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RY70_RS07625	COG0328	RNA-DNA hybrid ribonuclease activity
RY70_RS07645	COG0196	riboflavin kinase activity
RY70_RS07690	COG2308	Evidence 4 Homologs of previously reported genes of
RY70_RS07740	COG0201	protein transport
RY70_RS07800	COG0255	Belongs to the universal ribosomal protein uL29 family
RY70_RS07865	COG3527	Alpha-acetolactate decarboxylase
RY70_RS07870	COG1012	belongs to the aldehyde dehydrogenase family
RY70_RS07870	COG1454	alcohol dehydrogenase
RY70_RS07905	COG1739	Uncharacterized protein family UPF0029
RY70_RS07920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RY70_RS07930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RY70_RS07935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RY70_RS07965	COG0714	Associated with various cellular activities
RY70_RS07990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RY70_RS08030	COG0657	acetylesterase activity
RY70_RS08030	COG2755	lipolytic protein G-D-S-L family
RY70_RS08035	COG4409	exo-alpha-(2->6)-sialidase activity
RY70_RS08045	COG2252	PERMEase
RY70_RS08060	COG0581	inorganic phosphate transmembrane transporter activity
RY70_RS08075	COG0745	RESPONSE REGULATOR receiver
RY70_RS08080	COG5002	protein histidine kinase activity
RY70_RS08090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY70_RS08105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY70_RS08125	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RY70_RS08140	COG0826	peptidase U32
RY70_RS08150	COG0656	L-ascorbic acid biosynthetic process
RY70_RS08165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RY70_RS08170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RY70_RS08185	COG1704	LemA family
RY70_RS08190	COG1609	Transcriptional regulator
RY70_RS08235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RY70_RS08240	COG4770	biotin carboxylase activity
RY70_RS08245	COG1268	BioY protein
RY70_RS08250	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RY70_RS08250	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RY70_RS08270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RY70_RS08305	COG0356	it plays a direct role in the translocation of protons across the membrane
RY70_RS08340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RY70_RS08355	COG0745	RESPONSE REGULATOR receiver
RY70_RS08365	COG0747	negative chemotaxis
RY70_RS08380	COG1605	Chorismate mutase
RY70_RS08380	COG0287	Prephenate dehydrogenase
RY70_RS08385	COG1522	sequence-specific DNA binding
RY70_RS08390	COG0436	Aminotransferase
RY70_RS08435	COG1131	(ABC) transporter
RY70_RS08450	COG1322	Protein conserved in bacteria
RY70_RS08455	COG1937	Protein conserved in bacteria
RY70_RS08480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RY70_RS08485	COG0305	Participates in initiation and elongation during chromosome replication
RY70_RS08495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RY70_RS08515	COG1309	transcriptional regulator
RY70_RS08520	COG1216	Glycosyl transferase, family 2
RY70_RS08555	COG1132	(ABC) transporter
RY70_RS08595	COG0561	phosphatase activity
RY70_RS08610	COG0561	phosphatase activity
RY70_RS08615	COG2723	6-phospho-beta-galactosidase activity
RY70_RS08630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RY70_RS08645	COG1609	Transcriptional regulator
RY70_RS08660	COG0577	efflux transmembrane transporter activity
RY70_RS08675	COG3470	protein probably involved in high-affinity Fe2 transport
RY70_RS08680	COG0672	)-iron permease
RY70_RS08710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RY70_RS08715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY70_RS08715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RY70_RS08725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RY70_RS08735	COG1754	DNA topoisomerase type I activity
RY70_RS08735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RY70_RS08745	COG1404	Belongs to the peptidase S8 family
RY70_RS08760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RY70_RS08815	COG1597	lipid kinase activity
RY70_RS08855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RY70_RS08860	COG0494	nUDIX hydrolase
RY70_RS08860	COG0406	alpha-ribazole phosphatase activity
RY70_RS08875	COG1216	Glycosyl transferase, family 2
RY70_RS08905	COG0463	Glycosyl transferase, family 2
RY70_RS08920	COG1136	(ABC) transporter
RY70_RS08945	COG0084	hydrolase, TatD family'
RY70_RS08985	COG0586	Pfam SNARE associated Golgi protein
RY70_RS09010	COG0789	Transcriptional regulator
RY70_RS09035	COG1609	Transcriptional regulator
RY70_RS09045	COG0588	phosphoglycerate mutase activity
RY70_RS09055	COG0778	Nitroreductase