locus-tag	class	description
BBB_RS00010	COG0592	DNA-directed DNA polymerase activity
BBB_RS00025	COG0187	DNA topoisomerase II activity
BBB_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBB_RS00090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBB_RS00100	COG1970	mechanosensitive ion channel activity
BBB_RS00105	COG3534	alpha-L-arabinofuranosidase
BBB_RS00130	COG1609	Transcriptional regulator
BBB_RS00135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB_RS00155	COG0783	Belongs to the Dps family
BBB_RS00165	COG1253	flavin adenine dinucleotide binding
BBB_RS00175	COG0288	reversible hydration of carbon dioxide
BBB_RS00200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BBB_RS00220	COG0180	Tryptophanyl-tRNA synthetase
BBB_RS00230	COG3279	Response regulator of the LytR AlgR family
BBB_RS00240	COG1088	dTDP-glucose 4,6-dehydratase activity
BBB_RS00310	COG1216	Glycosyl transferase, family 2
BBB_RS00330	COG1088	dTDP-glucose 4,6-dehydratase activity
BBB_RS00340	COG1309	transcriptional regulator
BBB_RS00350	COG2814	Major facilitator Superfamily
BBB_RS00355	COG2801	Transposase and inactivated derivatives
BBB_RS00375	COG0058	SHG alpha-glucan phosphorylase activity
BBB_RS00425	COG0515	serine threonine protein kinase
BBB_RS00430	COG0768	penicillin binding
BBB_RS00490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB_RS00490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB_RS00500	COG0513	Belongs to the DEAD box helicase family
BBB_RS00505	COG0494	nUDIX hydrolase
BBB_RS00585	COG0343	queuine tRNA-ribosyltransferase activity
BBB_RS00595	COG2217	Heavy metal translocating P-type atpase
BBB_RS00660	COG0191	fructose-bisphosphate aldolase activity
BBB_RS00695	COG0477	Major facilitator Superfamily
BBB_RS00715	COG3250	beta-galactosidase activity
BBB_RS00720	COG1113	amino acid transport
BBB_RS00735	COG1136	(ABC) transporter
BBB_RS00735	COG0577	efflux transmembrane transporter activity
BBB_RS00810	COG0477	Major facilitator Superfamily
BBB_RS00820	COG2801	Transposase and inactivated derivatives
BBB_RS00855	COG0667	Aldo Keto reductase
BBB_RS00865	COG1846	Transcriptional regulator
BBB_RS00875	COG1132	(ABC) transporter
BBB_RS00925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBB_RS00935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBB_RS00985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBB_RS01000	COG0167	dihydroorotate dehydrogenase activity
BBB_RS01005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBB_RS01015	COG1309	transcriptional regulator
BBB_RS01080	COG4948	Mandelate Racemase Muconate Lactonizing
BBB_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
BBB_RS01100	COG0251	oxidation-reduction process
BBB_RS01105	COG0584	glycerophosphoryl diester phosphodiesterase
BBB_RS01120	COG1263	PTS System
BBB_RS01120	COG2190	(PTS) system
BBB_RS01120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB_RS01125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB_RS01125	COG2190	(PTS) system
BBB_RS01125	COG1263	PTS System
BBB_RS01130	COG0460	homoserine dehydrogenase
BBB_RS01135	COG0083	homoserine kinase activity
BBB_RS01155	COG1136	(ABC) transporter
BBB_RS01170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBB_RS01175	COG1530	ribonuclease E activity
BBB_RS01205	COG0436	Aminotransferase
BBB_RS01215	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBB_RS01240	COG0584	glycerophosphoryl diester phosphodiesterase
BBB_RS01245	COG0366	Alpha amylase catalytic
BBB_RS01310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBB_RS01355	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBB_RS01385	COG0436	Aminotransferase
BBB_RS01410	COG1022	Amp-dependent synthetase and ligase
BBB_RS01490	COG0789	Transcriptional regulator
BBB_RS01495	COG2270	Major facilitator Superfamily
BBB_RS01535	COG1301	dicarboxylic acid transport
BBB_RS01540	COG0742	ribosomal rna small subunit methyltransferase
BBB_RS01550	COG0071	Belongs to the small heat shock protein (HSP20) family
BBB_RS01565	COG1837	Belongs to the UPF0109 family
BBB_RS01575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBB_RS01605	COG0519	Catalyzes the synthesis of GMP from XMP
BBB_RS01610	COG0488	(ABC) transporter
BBB_RS01650	COG0440	acetolactate synthase activity
BBB_RS01720	COG1285	pathogenesis
BBB_RS01725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BBB_RS01730	COG1116	anion transmembrane transporter activity
BBB_RS01745	COG3775	system Galactitol-specific IIC component
BBB_RS01775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBB_RS01780	COG1609	Transcriptional regulator
BBB_RS01815	COG1609	Transcriptional regulator
BBB_RS01820	COG0656	L-ascorbic acid biosynthetic process
BBB_RS01835	COG2814	Major facilitator Superfamily
BBB_RS01850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBB_RS01895	COG0095	Lipoate-protein ligase
BBB_RS01900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBB_RS01905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBB_RS01910	COG1902	pentaerythritol trinitrate reductase activity
BBB_RS01915	COG0167	dihydroorotate dehydrogenase activity
BBB_RS01920	COG1349	DNA-binding transcription factor activity
BBB_RS01930	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BBB_RS01935	COG0477	Major facilitator Superfamily
BBB_RS01960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBB_RS02020	COG0714	Associated with various cellular activities
BBB_RS02080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BBB_RS02090	COG1404	Belongs to the peptidase S8 family
BBB_RS02115	COG0436	Aminotransferase
BBB_RS02120	COG0248	Ppx GppA phosphatase
BBB_RS02135	COG2210	Belongs to the sulfur carrier protein TusA family
BBB_RS02155	COG1722	exodeoxyribonuclease VII activity
BBB_RS02160	COG1570	exodeoxyribonuclease VII activity
BBB_RS02165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBB_RS02165	COG1328	CTP reductase activity
BBB_RS02170	COG0602	queuosine metabolic process
BBB_RS02205	COG1132	(ABC) transporter
BBB_RS02210	COG1132	(ABC) transporter
BBB_RS02225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBB_RS02235	COG0613	PHP domain protein
BBB_RS02260	COG3480	Lon protease (S16) C-terminal proteolytic domain
BBB_RS02280	COG0351	phosphomethylpyrimidine kinase
BBB_RS02285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBB_RS02305	COG3250	beta-galactosidase activity
BBB_RS02320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBB_RS02365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBB_RS02370	COG2884	Cell division ATP-binding protein ftsE
BBB_RS02375	COG2177	Part of the ABC transporter FtsEX involved in
BBB_RS02380	COG3942	CHAP domain
BBB_RS02380	COG1705	Flagellar rod assembly protein muramidase FlgJ
BBB_RS02390	COG0564	pseudouridine synthase activity
BBB_RS02445	COG3878	Protein conserved in bacteria
BBB_RS02450	COG1621	beta-fructofuranosidase activity
BBB_RS02455	COG0587	DNA-directed DNA polymerase activity
BBB_RS02470	COG4716	Myosin-crossreactive antigen
BBB_RS02475	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBB_RS02485	COG0656	L-ascorbic acid biosynthetic process
BBB_RS02570	COG1643	Atp-dependent helicase
BBB_RS02575	COG2813	Specifically methylates the guanine in position
BBB_RS02585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBB_RS02615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBB_RS02640	COG0768	penicillin binding
BBB_RS02650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBB_RS02735	COG0601	transmembrane transport
BBB_RS02740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB_RS02750	COG0006	proline dipeptidase activity
BBB_RS02760	COG0285	dihydrofolate synthase activity
BBB_RS02765	COG1196	nuclear chromosome segregation
BBB_RS02770	COG1794	racemase activity, acting on amino acids and derivatives
BBB_RS02795	COG1595	DNA-templated transcription, initiation
BBB_RS02805	COG2017	converts alpha-aldose to the beta-anomer
BBB_RS02820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBB_RS02840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BBB_RS02870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BBB_RS02880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BBB_RS02885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BBB_RS02895	COG1104	cysteine desulfurase activity
BBB_RS02900	COG1217	gtp-binding protein TYPA
BBB_RS02915	COG0287	Prephenate dehydrogenase
BBB_RS02955	COG0708	Exodeoxyribonuclease III
BBB_RS03015	COG1011	Hydrolase
BBB_RS03025	COG0560	Phosphoserine phosphatase
BBB_RS03030	COG1222	aaa ATPase
BBB_RS03035	COG4122	O-methyltransferase activity
BBB_RS03065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBB_RS03105	COG0714	Associated with various cellular activities
BBB_RS03120	COG1278	Cold shock
BBB_RS03140	COG0745	RESPONSE REGULATOR receiver
BBB_RS03145	COG2205	protein histidine kinase activity
BBB_RS03150	COG1278	Cold shock
BBB_RS03185	COG1196	nuclear chromosome segregation
BBB_RS03210	COG1126	abc transporter atp-binding protein
BBB_RS03215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB_RS03220	COG0765	amino acid transport
BBB_RS03225	COG0765	amino acid transport
BBB_RS03230	COG2326	polyphosphate kinase activity
BBB_RS03245	COG2814	Major facilitator Superfamily
BBB_RS03270	COG1122	ATPase activity
BBB_RS03305	COG0582	viral genome integration into host DNA
BBB_RS03360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB_RS03380	COG1136	(ABC) transporter
BBB_RS03405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BBB_RS03435	COG1682	transport, permease protein
BBB_RS03440	COG1134	teichoic acid transport
BBB_RS03465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBB_RS03500	COG1760	l-serine dehydratase
BBB_RS03510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBB_RS03535	COG1674	ftsk spoiiie
BBB_RS03540	COG1316	TRANSCRIPTIONal
BBB_RS03570	COG1040	competence protein
BBB_RS03580	COG2205	protein histidine kinase activity
BBB_RS03585	COG0745	RESPONSE REGULATOR receiver
BBB_RS03610	COG1121	(ABC) transporter
BBB_RS03625	COG0539	negative regulation of cytoplasmic translation
BBB_RS03645	COG0469	pyruvate kinase activity
BBB_RS03650	COG0494	nUDIX hydrolase
BBB_RS03670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBB_RS03675	COG0494	nUDIX hydrolase
BBB_RS03695	COG4974	Belongs to the 'phage' integrase family
BBB_RS03700	COG3340	Belongs to the peptidase S51 family
BBB_RS03710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBB_RS03715	COG0280	phosphate acetyltransferase
BBB_RS03715	COG0857	belongs to the CobB CobQ family
BBB_RS03720	COG4868	Belongs to the UPF0371 family
BBB_RS03800	COG0306	phosphate transporter
BBB_RS03810	COG2197	response regulator
BBB_RS03815	COG4585	Histidine kinase
BBB_RS03825	COG1131	(ABC) transporter
BBB_RS03845	COG2826	transposase and inactivated derivatives, IS30 family
BBB_RS03870	COG2801	Transposase and inactivated derivatives
BBB_RS03885	COG1335	isochorismatase
BBB_RS03920	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BBB_RS03920	COG2755	lipolytic protein G-D-S-L family
BBB_RS03950	COG2755	lipolytic protein G-D-S-L family
BBB_RS03950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BBB_RS04000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBB_RS04030	COG0719	Fe-S assembly protein
BBB_RS04035	COG0396	ATPase activity
BBB_RS04050	COG2151	metal-sulfur cluster biosynthetic enzyme
BBB_RS04070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BBB_RS04075	COG0537	adenosine 5'-monophosphoramidase activity
BBB_RS04105	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BBB_RS04130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBB_RS04140	COG2860	membrane
BBB_RS04160	COG0436	Aminotransferase
BBB_RS04170	COG0070	glutamate synthase
BBB_RS04170	COG0069	glutamate synthase activity
BBB_RS04170	COG0067	glutamate synthase
BBB_RS04185	COG0297	glycogen (starch) synthase activity
BBB_RS04190	COG1119	ATPase activity
BBB_RS04195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BBB_RS04210	COG2826	transposase and inactivated derivatives, IS30 family
BBB_RS04215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBB_RS04260	COG2962	Rard protein
BBB_RS04270	COG1073	alpha beta
BBB_RS04280	COG2062	phosphohistidine phosphatase, SixA
BBB_RS04290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BBB_RS04315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBB_RS04320	COG0284	orotidine-5'-phosphate decarboxylase activity
BBB_RS04325	COG0543	2 iron, 2 sulfur cluster binding
BBB_RS04330	COG0167	dihydroorotate dehydrogenase activity
BBB_RS04345	COG1063	alcohol dehydrogenase
BBB_RS04365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBB_RS04375	COG4221	oxidoreductase activity
BBB_RS04395	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BBB_RS04410	COG4106	trans-aconitate 2-methyltransferase activity
BBB_RS04420	COG3226	Transcriptional regulator
BBB_RS04430	COG0583	DNA-binding transcription factor activity
BBB_RS04490	COG1803	Methylglyoxal synthase
BBB_RS04565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBB_RS04580	COG0133	tryptophan synthase activity
BBB_RS04595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBB_RS04620	COG0045	succinate-CoA ligase (ADP-forming) activity
BBB_RS04630	COG1862	Preprotein translocase
BBB_RS04665	COG1301	dicarboxylic acid transport
BBB_RS04730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBB_RS04735	COG3619	membrane
BBB_RS04740	COG1114	Component of the transport system for branched-chain amino acids
BBB_RS04770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBB_RS04795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBB_RS04820	COG0745	RESPONSE REGULATOR receiver
BBB_RS04825	COG2205	protein histidine kinase activity
BBB_RS04830	COG1876	peptidase activity
BBB_RS04835	COG0488	(ABC) transporter
BBB_RS04855	COG1940	carbohydrate kinase activity
BBB_RS04860	COG1940	carbohydrate kinase activity
BBB_RS04870	COG0395	ABC-type sugar transport system, permease component
BBB_RS04875	COG1175	transmembrane transport
BBB_RS04945	COG1022	Amp-dependent synthetase and ligase
BBB_RS04955	COG0516	GMP reductase activity
BBB_RS04970	COG1022	Amp-dependent synthetase and ligase
BBB_RS05005	COG0802	atpase or kinase
BBB_RS05030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB_RS05040	COG0406	alpha-ribazole phosphatase activity
BBB_RS05070	COG3189	MarR family transcriptional regulator
BBB_RS05090	COG1051	belongs to the nudix hydrolase family
BBB_RS05125	COG2135	peptidase activity
BBB_RS05165	COG2249	NAD(P)H dehydrogenase (quinone) activity
BBB_RS05240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBB_RS05270	COG1131	(ABC) transporter
BBB_RS05280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBB_RS05285	COG0497	DNA recombination
BBB_RS05300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBB_RS05305	COG0569	domain protein
BBB_RS05320	COG0647	UMP catabolic process
BBB_RS05350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BBB_RS05435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBB_RS05440	COG1136	(ABC) transporter
BBB_RS05445	COG0390	transport system, permease component
BBB_RS05460	COG2233	PERMEase
BBB_RS05480	COG0583	DNA-binding transcription factor activity
BBB_RS05495	COG1442	glycosyl transferase family 8
BBB_RS05495	COG1216	Glycosyl transferase, family 2
BBB_RS05520	COG0242	peptide deformylase activity
BBB_RS05585	COG3177	Filamentation induced by cAMP protein fic
BBB_RS05590	COG0012	GTP binding
BBB_RS05595	COG0436	Aminotransferase
BBB_RS05605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBB_RS05610	COG0022	dehydrogenase e1 component
BBB_RS05610	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBB_RS05615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BBB_RS05630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBB_RS05645	COG2197	response regulator
BBB_RS05650	COG0671	phosphoesterase, PA-phosphatase related
BBB_RS05655	COG1136	(ABC) transporter
BBB_RS05655	COG0577	efflux transmembrane transporter activity
BBB_RS05660	COG1136	(ABC) transporter
BBB_RS05680	COG2873	o-acetylhomoserine
BBB_RS05695	COG1053	succinate dehydrogenase
BBB_RS05730	COG1611	Belongs to the LOG family
BBB_RS05735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBB_RS05740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BBB_RS05795	COG1882	Formate acetyltransferase
BBB_RS05810	COG1473	amidohydrolase
BBB_RS05820	COG0561	phosphatase activity
BBB_RS05865	COG0489	protein tyrosine kinase activity
BBB_RS05900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBB_RS05900	COG0551	DNA topoisomerase type I activity
BBB_RS05925	COG3843	relaxase mobilization nuclease domain protein
BBB_RS05985	COG0739	heme binding
BBB_RS05985	COG0741	lytic transglycosylase activity
BBB_RS05985	COG1196	nuclear chromosome segregation
BBB_RS06025	COG2217	Heavy metal translocating P-type atpase
BBB_RS06085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBB_RS06110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBB_RS06115	COG1201	RNA secondary structure unwinding
BBB_RS06120	COG3655	Transcriptional regulator
BBB_RS06130	COG1027	Aspartate ammonia-lyase
BBB_RS06135	COG0187	DNA topoisomerase II activity
BBB_RS06140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBB_RS06150	COG0142	geranyltranstransferase activity
BBB_RS06170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBB_RS06180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBB_RS06200	COG1396	sequence-specific DNA binding
BBB_RS06205	COG1546	Belongs to the CinA family
BBB_RS06205	COG1058	Belongs to the CinA family
BBB_RS06210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBB_RS06235	COG2357	RelA SpoT domain protein
BBB_RS06245	COG0670	Belongs to the BI1 family
BBB_RS06260	COG2197	response regulator
BBB_RS06275	COG0284	orotidine-5'-phosphate decarboxylase activity
BBB_RS06340	COG2873	o-acetylhomoserine
BBB_RS06400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBB_RS06420	COG1368	sulfuric ester hydrolase activity
BBB_RS06425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BBB_RS06430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BBB_RS06445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BBB_RS06450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBB_RS06460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBB_RS06470	COG0701	Predicted permease
BBB_RS06490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BBB_RS06495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BBB_RS06505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBB_RS06515	COG1355	regulation of microtubule-based process
BBB_RS06525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBB_RS06540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBB_RS06545	COG0531	amino acid
BBB_RS06560	COG0514	ATP-dependent DNA helicase (RecQ)
BBB_RS06610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB_RS06645	COG0395	ABC-type sugar transport system, permease component
BBB_RS06670	COG1950	PFAM Membrane protein of
BBB_RS06675	COG1012	belongs to the aldehyde dehydrogenase family
BBB_RS06695	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBB_RS06700	COG1929	Belongs to the glycerate kinase type-1 family
BBB_RS06705	COG0577	efflux transmembrane transporter activity
BBB_RS06705	COG1136	(ABC) transporter
BBB_RS06710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BBB_RS06720	COG0667	Aldo Keto reductase
BBB_RS06725	COG2176	DNA-directed DNA polymerase activity
BBB_RS06735	COG0024	Methionine aminopeptidase
BBB_RS06745	COG3590	peptidase
BBB_RS06770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBB_RS06785	COG2205	protein histidine kinase activity
BBB_RS06795	COG0366	Alpha amylase catalytic
BBB_RS06805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBB_RS06810	COG0009	L-threonylcarbamoyladenylate synthase
BBB_RS06845	COG4975	Glucose uptake
BBB_RS06850	COG0673	inositol 2-dehydrogenase activity
BBB_RS06855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBB_RS06875	COG0513	Belongs to the DEAD box helicase family
BBB_RS06885	COG0577	efflux transmembrane transporter activity
BBB_RS06905	COG2873	o-acetylhomoserine
BBB_RS06920	COG1940	carbohydrate kinase activity
BBB_RS06925	COG0488	(ABC) transporter
BBB_RS06930	COG0477	Major facilitator Superfamily
BBB_RS06960	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BBB_RS06995	COG1946	Acyl-CoA thioesterase
BBB_RS07005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBB_RS07010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BBB_RS07020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBB_RS07025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BBB_RS07050	COG1215	transferase activity, transferring glycosyl groups
BBB_RS07060	COG1216	Glycosyl transferase, family 2
BBB_RS07065	COG1454	alcohol dehydrogenase
BBB_RS07085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBB_RS07105	COG3250	beta-galactosidase activity
BBB_RS07115	COG1609	Transcriptional regulator
BBB_RS07120	COG5002	protein histidine kinase activity
BBB_RS07125	COG0745	RESPONSE REGULATOR receiver
BBB_RS07155	COG1136	(ABC) transporter
BBB_RS07170	COG0577	efflux transmembrane transporter activity
BBB_RS07180	COG1136	(ABC) transporter
BBB_RS07200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BBB_RS07215	COG0589	response to stress
BBB_RS07225	COG3942	CHAP domain
BBB_RS07225	COG1388	LysM domain
BBB_RS07230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BBB_RS07240	COG5002	protein histidine kinase activity
BBB_RS07245	COG0704	Plays a role in the regulation of phosphate uptake
BBB_RS07265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBB_RS07275	COG2814	Major facilitator Superfamily
BBB_RS07305	COG2197	response regulator
BBB_RS07310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BBB_RS07315	COG0363	glucosamine-6-phosphate deaminase activity
BBB_RS07355	COG1525	nuclease
BBB_RS07355	COG0737	Belongs to the 5'-nucleotidase family
BBB_RS07355	COG4085	toxin activity
BBB_RS07360	COG1597	lipid kinase activity
BBB_RS07360	COG1803	Methylglyoxal synthase
BBB_RS07365	COG3711	transcriptional antiterminator
BBB_RS07370	COG1263	PTS System
BBB_RS07370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB_RS07370	COG2190	(PTS) system
BBB_RS07395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB_RS07405	COG0328	RNA-DNA hybrid ribonuclease activity
BBB_RS07425	COG0196	riboflavin kinase activity
BBB_RS07470	COG2308	Evidence 4 Homologs of previously reported genes of
BBB_RS07520	COG0201	protein transport
BBB_RS07580	COG0255	Belongs to the universal ribosomal protein uL29 family
BBB_RS07640	COG3527	Alpha-acetolactate decarboxylase
BBB_RS07645	COG1454	alcohol dehydrogenase
BBB_RS07645	COG1012	belongs to the aldehyde dehydrogenase family
BBB_RS07680	COG1739	Uncharacterized protein family UPF0029
BBB_RS07695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBB_RS07705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BBB_RS07710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBB_RS07740	COG0714	Associated with various cellular activities
BBB_RS07765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBB_RS07805	COG2755	lipolytic protein G-D-S-L family
BBB_RS07805	COG0657	acetylesterase activity
BBB_RS07810	COG4409	exo-alpha-(2->6)-sialidase activity
BBB_RS07820	COG2252	PERMEase
BBB_RS07835	COG0581	inorganic phosphate transmembrane transporter activity
BBB_RS07850	COG0745	RESPONSE REGULATOR receiver
BBB_RS07855	COG5002	protein histidine kinase activity
BBB_RS07865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBB_RS07880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBB_RS07900	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BBB_RS07915	COG0826	peptidase U32
BBB_RS07925	COG0656	L-ascorbic acid biosynthetic process
BBB_RS07940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBB_RS07945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBB_RS07960	COG1704	LemA family
BBB_RS08010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBB_RS08015	COG4770	biotin carboxylase activity
BBB_RS08020	COG1268	BioY protein
BBB_RS08025	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BBB_RS08025	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BBB_RS08045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BBB_RS08080	COG0356	it plays a direct role in the translocation of protons across the membrane
BBB_RS08200	COG4974	Belongs to the 'phage' integrase family
BBB_RS08225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBB_RS08240	COG0745	RESPONSE REGULATOR receiver
BBB_RS08250	COG0747	negative chemotaxis
BBB_RS08265	COG0287	Prephenate dehydrogenase
BBB_RS08265	COG1605	Chorismate mutase
BBB_RS08270	COG1522	sequence-specific DNA binding
BBB_RS08275	COG0436	Aminotransferase
BBB_RS08320	COG1131	(ABC) transporter
BBB_RS08335	COG1322	Protein conserved in bacteria
BBB_RS08340	COG1937	Protein conserved in bacteria
BBB_RS08365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBB_RS08370	COG0305	Participates in initiation and elongation during chromosome replication
BBB_RS08380	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BBB_RS08400	COG1309	transcriptional regulator
BBB_RS08405	COG1216	Glycosyl transferase, family 2
BBB_RS08435	COG1132	(ABC) transporter
BBB_RS08475	COG0561	phosphatase activity
BBB_RS08490	COG0560	Phosphoserine phosphatase
BBB_RS08490	COG3830	Belongs to the UPF0237 family
BBB_RS08495	COG2723	6-phospho-beta-galactosidase activity
BBB_RS08510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BBB_RS08520	COG1609	Transcriptional regulator
BBB_RS08535	COG0577	efflux transmembrane transporter activity
BBB_RS08540	COG0577	efflux transmembrane transporter activity
BBB_RS08550	COG3470	protein probably involved in high-affinity Fe2 transport
BBB_RS08555	COG0672	)-iron permease
BBB_RS08585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBB_RS08600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BBB_RS08610	COG1754	DNA topoisomerase type I activity
BBB_RS08610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBB_RS08620	COG1404	Belongs to the peptidase S8 family
BBB_RS08635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBB_RS08690	COG1597	lipid kinase activity
BBB_RS08735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BBB_RS08740	COG0494	nUDIX hydrolase
BBB_RS08740	COG0406	alpha-ribazole phosphatase activity
BBB_RS08760	COG1216	Glycosyl transferase, family 2
BBB_RS08785	COG0463	Glycosyl transferase, family 2
BBB_RS08800	COG1136	(ABC) transporter
BBB_RS08825	COG0084	hydrolase, TatD family'
BBB_RS08865	COG0586	Pfam SNARE associated Golgi protein
BBB_RS08890	COG0789	Transcriptional regulator
BBB_RS08915	COG1609	Transcriptional regulator
BBB_RS08925	COG0588	phosphoglycerate mutase activity
BBB_RS08935	COG0778	Nitroreductase
BBB_RS08960	COG3231	kanamycin kinase activity
BBB_RS08980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBB_RS08985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBB_RS08990	COG0590	tRNA wobble adenosine to inosine editing
BBB_RS08990	COG0037	tRNA processing
BBB_RS09000	COG0025	NhaP-type Na H and K H
BBB_RS09015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BBB_RS09020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBB_RS09050	COG2826	transposase and inactivated derivatives, IS30 family
BBB_RS09055	COG3842	ATPase activity
BBB_RS09080	COG3583	domain protein
BBB_RS09100	COG0617	tRNA 3'-terminal CCA addition
BBB_RS09120	COG0492	ferredoxin-NADP+ reductase activity
BBB_RS09130	COG1192	Involved in chromosome partitioning
BBB_RS09140	COG1847	R3H domain protein
BBB_RS09195	COG0210	DNA helicase
BBB_RS09215	COG1609	Transcriptional regulator