locus-tag	class	description
JQN90_RS00035	COG3177	Filamentation induced by cAMP protein fic
JQN90_RS00040	COG0012	GTP binding
JQN90_RS00045	COG0436	Aminotransferase
JQN90_RS00055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JQN90_RS00060	COG0022	dehydrogenase e1 component
JQN90_RS00060	COG0508	dehydrogenase complex catalyzes the overall conversion of
JQN90_RS00065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JQN90_RS00080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JQN90_RS00095	COG2197	response regulator
JQN90_RS00100	COG0671	phosphoesterase, PA-phosphatase related
JQN90_RS00105	COG0577	efflux transmembrane transporter activity
JQN90_RS00105	COG1136	(ABC) transporter
JQN90_RS00110	COG1136	(ABC) transporter
JQN90_RS00135	COG2873	o-acetylhomoserine
JQN90_RS00150	COG1053	succinate dehydrogenase
JQN90_RS00185	COG1611	Belongs to the LOG family
JQN90_RS00190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JQN90_RS00195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JQN90_RS00250	COG1882	Formate acetyltransferase
JQN90_RS00265	COG1473	amidohydrolase
JQN90_RS00275	COG0561	phosphatase activity
JQN90_RS00315	COG0489	protein tyrosine kinase activity
JQN90_RS00350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JQN90_RS00350	COG0551	DNA topoisomerase type I activity
JQN90_RS00375	COG3843	relaxase mobilization nuclease domain protein
JQN90_RS00435	COG1196	nuclear chromosome segregation
JQN90_RS00435	COG0739	heme binding
JQN90_RS00435	COG0741	lytic transglycosylase activity
JQN90_RS00475	COG2217	Heavy metal translocating P-type atpase
JQN90_RS00540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JQN90_RS00565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JQN90_RS00570	COG1201	RNA secondary structure unwinding
JQN90_RS00575	COG3655	Transcriptional regulator
JQN90_RS00585	COG1027	Aspartate ammonia-lyase
JQN90_RS00590	COG0187	DNA topoisomerase II activity
JQN90_RS00595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JQN90_RS00605	COG0142	geranyltranstransferase activity
JQN90_RS00625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JQN90_RS00635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JQN90_RS00665	COG1396	sequence-specific DNA binding
JQN90_RS00670	COG1058	Belongs to the CinA family
JQN90_RS00670	COG1546	Belongs to the CinA family
JQN90_RS00675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JQN90_RS00700	COG2357	RelA SpoT domain protein
JQN90_RS00710	COG0670	Belongs to the BI1 family
JQN90_RS00725	COG2197	response regulator
JQN90_RS00795	COG2873	o-acetylhomoserine
JQN90_RS00855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JQN90_RS00875	COG1368	sulfuric ester hydrolase activity
JQN90_RS00880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JQN90_RS00885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JQN90_RS00900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JQN90_RS00905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JQN90_RS00915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JQN90_RS00925	COG0701	Predicted permease
JQN90_RS00945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JQN90_RS00950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JQN90_RS00960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JQN90_RS00970	COG1355	regulation of microtubule-based process
JQN90_RS00980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JQN90_RS00995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JQN90_RS01000	COG0531	amino acid
JQN90_RS01015	COG0514	ATP-dependent DNA helicase (RecQ)
JQN90_RS01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JQN90_RS01105	COG0395	ABC-type sugar transport system, permease component
JQN90_RS01135	COG1950	PFAM Membrane protein of
JQN90_RS01140	COG1012	belongs to the aldehyde dehydrogenase family
JQN90_RS01160	COG0446	pyridine nucleotide-disulphide oxidoreductase
JQN90_RS01165	COG1929	Belongs to the glycerate kinase type-1 family
JQN90_RS01170	COG1136	(ABC) transporter
JQN90_RS01170	COG0577	efflux transmembrane transporter activity
JQN90_RS01175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JQN90_RS01185	COG0667	Aldo Keto reductase
JQN90_RS01190	COG2176	DNA-directed DNA polymerase activity
JQN90_RS01200	COG0024	Methionine aminopeptidase
JQN90_RS01210	COG3590	peptidase
JQN90_RS01235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JQN90_RS01250	COG2205	protein histidine kinase activity
JQN90_RS01260	COG0366	Alpha amylase catalytic
JQN90_RS01270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JQN90_RS01275	COG0009	L-threonylcarbamoyladenylate synthase
JQN90_RS01310	COG4975	Glucose uptake
JQN90_RS01315	COG0673	inositol 2-dehydrogenase activity
JQN90_RS01320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JQN90_RS01335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JQN90_RS01355	COG0513	Belongs to the DEAD box helicase family
JQN90_RS01370	COG0577	efflux transmembrane transporter activity
JQN90_RS01390	COG2873	o-acetylhomoserine
JQN90_RS01405	COG1940	carbohydrate kinase activity
JQN90_RS01410	COG0488	(ABC) transporter
JQN90_RS01415	COG0477	Major facilitator Superfamily
JQN90_RS01445	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JQN90_RS01480	COG1946	Acyl-CoA thioesterase
JQN90_RS01490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JQN90_RS01495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JQN90_RS01505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JQN90_RS01510	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JQN90_RS01535	COG1215	transferase activity, transferring glycosyl groups
JQN90_RS01545	COG1216	Glycosyl transferase, family 2
JQN90_RS01550	COG1454	alcohol dehydrogenase
JQN90_RS01570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JQN90_RS01590	COG3250	beta-galactosidase activity
JQN90_RS01600	COG1609	Transcriptional regulator
JQN90_RS01605	COG5002	protein histidine kinase activity
JQN90_RS01610	COG0745	RESPONSE REGULATOR receiver
JQN90_RS01640	COG1136	(ABC) transporter
JQN90_RS01655	COG0577	efflux transmembrane transporter activity
JQN90_RS01665	COG1136	(ABC) transporter
JQN90_RS01690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JQN90_RS01705	COG0589	response to stress
JQN90_RS01715	COG1388	LysM domain
JQN90_RS01715	COG3942	CHAP domain
JQN90_RS01720	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JQN90_RS01730	COG5002	protein histidine kinase activity
JQN90_RS01735	COG0704	Plays a role in the regulation of phosphate uptake
JQN90_RS01755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JQN90_RS01765	COG2814	Major facilitator Superfamily
JQN90_RS01795	COG2197	response regulator
JQN90_RS01800	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JQN90_RS01805	COG0363	glucosamine-6-phosphate deaminase activity
JQN90_RS01845	COG0737	Belongs to the 5'-nucleotidase family
JQN90_RS01845	COG1525	nuclease
JQN90_RS01845	COG4085	toxin activity
JQN90_RS01850	COG1597	lipid kinase activity
JQN90_RS01850	COG1803	Methylglyoxal synthase
JQN90_RS01855	COG3711	transcriptional antiterminator
JQN90_RS01860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JQN90_RS01860	COG1263	PTS System
JQN90_RS01860	COG2190	(PTS) system
JQN90_RS01885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JQN90_RS01895	COG0328	RNA-DNA hybrid ribonuclease activity
JQN90_RS01920	COG0196	riboflavin kinase activity
JQN90_RS01965	COG2308	Evidence 4 Homologs of previously reported genes of
JQN90_RS02015	COG0201	protein transport
JQN90_RS02075	COG0255	Belongs to the universal ribosomal protein uL29 family
JQN90_RS02135	COG3527	Alpha-acetolactate decarboxylase
JQN90_RS02140	COG1454	alcohol dehydrogenase
JQN90_RS02140	COG1012	belongs to the aldehyde dehydrogenase family
JQN90_RS02175	COG1739	Uncharacterized protein family UPF0029
JQN90_RS02190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JQN90_RS02200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JQN90_RS02205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JQN90_RS02235	COG0714	Associated with various cellular activities
JQN90_RS02260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JQN90_RS02300	COG2755	lipolytic protein G-D-S-L family
JQN90_RS02300	COG0657	acetylesterase activity
JQN90_RS02305	COG4409	exo-alpha-(2->6)-sialidase activity
JQN90_RS02315	COG2252	PERMEase
JQN90_RS02330	COG0581	inorganic phosphate transmembrane transporter activity
JQN90_RS02345	COG0745	RESPONSE REGULATOR receiver
JQN90_RS02350	COG5002	protein histidine kinase activity
JQN90_RS02360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JQN90_RS02375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JQN90_RS02395	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JQN90_RS02410	COG0826	peptidase U32
JQN90_RS02420	COG0656	L-ascorbic acid biosynthetic process
JQN90_RS02435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JQN90_RS02440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JQN90_RS02455	COG1704	LemA family
JQN90_RS02505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JQN90_RS02510	COG4770	biotin carboxylase activity
JQN90_RS02515	COG1268	BioY protein
JQN90_RS02520	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JQN90_RS02520	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JQN90_RS02540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JQN90_RS02575	COG0356	it plays a direct role in the translocation of protons across the membrane
JQN90_RS02690	COG4974	Belongs to the 'phage' integrase family
JQN90_RS02720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JQN90_RS02735	COG0745	RESPONSE REGULATOR receiver
JQN90_RS02745	COG0747	negative chemotaxis
JQN90_RS02760	COG0287	Prephenate dehydrogenase
JQN90_RS02760	COG1605	Chorismate mutase
JQN90_RS02765	COG1522	sequence-specific DNA binding
JQN90_RS02770	COG0436	Aminotransferase
JQN90_RS02825	COG1322	Protein conserved in bacteria
JQN90_RS02830	COG1937	Protein conserved in bacteria
JQN90_RS02855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JQN90_RS02860	COG0305	Participates in initiation and elongation during chromosome replication
JQN90_RS02870	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JQN90_RS02890	COG1309	transcriptional regulator
JQN90_RS02895	COG1216	Glycosyl transferase, family 2
JQN90_RS02925	COG1132	(ABC) transporter
JQN90_RS02970	COG0561	phosphatase activity
JQN90_RS02985	COG0560	Phosphoserine phosphatase
JQN90_RS02985	COG3830	Belongs to the UPF0237 family
JQN90_RS02990	COG2723	6-phospho-beta-galactosidase activity
JQN90_RS03005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JQN90_RS03015	COG1609	Transcriptional regulator
JQN90_RS03030	COG0577	efflux transmembrane transporter activity
JQN90_RS03035	COG0577	efflux transmembrane transporter activity
JQN90_RS03045	COG3470	protein probably involved in high-affinity Fe2 transport
JQN90_RS03050	COG0672	)-iron permease
JQN90_RS03080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JQN90_RS03095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JQN90_RS03105	COG1754	DNA topoisomerase type I activity
JQN90_RS03105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JQN90_RS03120	COG1404	Belongs to the peptidase S8 family
JQN90_RS03135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JQN90_RS03190	COG1597	lipid kinase activity
JQN90_RS03230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JQN90_RS03235	COG0494	nUDIX hydrolase
JQN90_RS03235	COG0406	alpha-ribazole phosphatase activity
JQN90_RS03255	COG1216	Glycosyl transferase, family 2
JQN90_RS03295	COG1136	(ABC) transporter
JQN90_RS03320	COG0084	hydrolase, TatD family'
JQN90_RS03365	COG0586	Pfam SNARE associated Golgi protein
JQN90_RS03390	COG0789	Transcriptional regulator
JQN90_RS03415	COG1609	Transcriptional regulator
JQN90_RS03430	COG0588	phosphoglycerate mutase activity
JQN90_RS03440	COG0778	Nitroreductase
JQN90_RS03465	COG3231	kanamycin kinase activity
JQN90_RS03485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JQN90_RS03490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JQN90_RS03495	COG0037	tRNA processing
JQN90_RS03495	COG0590	tRNA wobble adenosine to inosine editing
JQN90_RS03505	COG0025	NhaP-type Na H and K H
JQN90_RS03520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JQN90_RS03525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JQN90_RS03555	COG2826	transposase and inactivated derivatives, IS30 family
JQN90_RS03560	COG3842	ATPase activity
JQN90_RS03585	COG3583	domain protein
JQN90_RS03605	COG0617	tRNA 3'-terminal CCA addition
JQN90_RS03625	COG0492	ferredoxin-NADP+ reductase activity
JQN90_RS03635	COG1192	Involved in chromosome partitioning
JQN90_RS03645	COG1847	R3H domain protein
JQN90_RS03675	COG0592	DNA-directed DNA polymerase activity
JQN90_RS03690	COG0187	DNA topoisomerase II activity
JQN90_RS03695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JQN90_RS03755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JQN90_RS03765	COG1970	mechanosensitive ion channel activity
JQN90_RS03770	COG3534	alpha-L-arabinofuranosidase
JQN90_RS03795	COG1609	Transcriptional regulator
JQN90_RS03800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JQN90_RS03820	COG0783	Belongs to the Dps family
JQN90_RS03830	COG1253	flavin adenine dinucleotide binding
JQN90_RS03840	COG0288	reversible hydration of carbon dioxide
JQN90_RS03865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JQN90_RS03885	COG0180	Tryptophanyl-tRNA synthetase
JQN90_RS03905	COG1088	dTDP-glucose 4,6-dehydratase activity
JQN90_RS03975	COG1216	Glycosyl transferase, family 2
JQN90_RS03995	COG1088	dTDP-glucose 4,6-dehydratase activity
JQN90_RS04005	COG1309	transcriptional regulator
JQN90_RS04015	COG2814	Major facilitator Superfamily
JQN90_RS04045	COG0058	SHG alpha-glucan phosphorylase activity
JQN90_RS04100	COG0515	serine threonine protein kinase
JQN90_RS04105	COG0768	penicillin binding
JQN90_RS04165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JQN90_RS04165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JQN90_RS04175	COG0513	Belongs to the DEAD box helicase family
JQN90_RS04180	COG0494	nUDIX hydrolase
JQN90_RS04260	COG0343	queuine tRNA-ribosyltransferase activity
JQN90_RS04270	COG2217	Heavy metal translocating P-type atpase
JQN90_RS04335	COG0191	fructose-bisphosphate aldolase activity
JQN90_RS04370	COG0477	Major facilitator Superfamily
JQN90_RS04390	COG3250	beta-galactosidase activity
JQN90_RS04395	COG1113	amino acid transport
JQN90_RS04405	COG1136	(ABC) transporter
JQN90_RS04405	COG0577	efflux transmembrane transporter activity
JQN90_RS04485	COG0477	Major facilitator Superfamily
JQN90_RS04525	COG0667	Aldo Keto reductase
JQN90_RS04540	COG1846	Transcriptional regulator
JQN90_RS04550	COG1132	(ABC) transporter
JQN90_RS04600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JQN90_RS04610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JQN90_RS04660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JQN90_RS04675	COG0167	dihydroorotate dehydrogenase activity
JQN90_RS04680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JQN90_RS04690	COG1309	transcriptional regulator
JQN90_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
JQN90_RS04770	COG0251	oxidation-reduction process
JQN90_RS04775	COG0584	glycerophosphoryl diester phosphodiesterase
JQN90_RS04790	COG2190	(PTS) system
JQN90_RS04790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JQN90_RS04790	COG1263	PTS System
JQN90_RS04795	COG2190	(PTS) system
JQN90_RS04795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JQN90_RS04795	COG1263	PTS System
JQN90_RS04800	COG0460	homoserine dehydrogenase
JQN90_RS04805	COG0083	homoserine kinase activity
JQN90_RS04825	COG1136	(ABC) transporter
JQN90_RS04840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JQN90_RS04845	COG1530	ribonuclease E activity
JQN90_RS04875	COG0436	Aminotransferase
JQN90_RS04885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JQN90_RS04910	COG0584	glycerophosphoryl diester phosphodiesterase
JQN90_RS04915	COG0366	Alpha amylase catalytic
JQN90_RS04980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JQN90_RS05025	COG0179	Fumarylacetoacetate (FAA) hydrolase
JQN90_RS05050	COG0436	Aminotransferase
JQN90_RS05085	COG1022	Amp-dependent synthetase and ligase
JQN90_RS05180	COG2270	Major facilitator Superfamily
JQN90_RS05215	COG1301	dicarboxylic acid transport
JQN90_RS05220	COG0742	ribosomal rna small subunit methyltransferase
JQN90_RS05230	COG0071	Belongs to the small heat shock protein (HSP20) family
JQN90_RS05245	COG1837	Belongs to the UPF0109 family
JQN90_RS05255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JQN90_RS05285	COG0519	Catalyzes the synthesis of GMP from XMP
JQN90_RS05290	COG0488	(ABC) transporter
JQN90_RS05330	COG0440	acetolactate synthase activity
JQN90_RS05395	COG1285	pathogenesis
JQN90_RS05400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JQN90_RS05405	COG1116	anion transmembrane transporter activity
JQN90_RS05420	COG3775	system Galactitol-specific IIC component
JQN90_RS05450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JQN90_RS05455	COG1609	Transcriptional regulator
JQN90_RS05490	COG1609	Transcriptional regulator
JQN90_RS05495	COG0656	L-ascorbic acid biosynthetic process
JQN90_RS05510	COG2814	Major facilitator Superfamily
JQN90_RS05525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JQN90_RS05570	COG0095	Lipoate-protein ligase
JQN90_RS05575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JQN90_RS05580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JQN90_RS05585	COG1902	pentaerythritol trinitrate reductase activity
JQN90_RS05590	COG0167	dihydroorotate dehydrogenase activity
JQN90_RS05595	COG1349	DNA-binding transcription factor activity
JQN90_RS05605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JQN90_RS05610	COG0477	Major facilitator Superfamily
JQN90_RS05630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JQN90_RS05690	COG0714	Associated with various cellular activities
JQN90_RS05750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JQN90_RS05760	COG1404	Belongs to the peptidase S8 family
JQN90_RS05785	COG0436	Aminotransferase
JQN90_RS05790	COG0248	Ppx GppA phosphatase
JQN90_RS05805	COG2210	Belongs to the sulfur carrier protein TusA family
JQN90_RS05825	COG1722	exodeoxyribonuclease VII activity
JQN90_RS05830	COG1570	exodeoxyribonuclease VII activity
JQN90_RS05835	COG1328	CTP reductase activity
JQN90_RS05835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JQN90_RS05840	COG0602	queuosine metabolic process
JQN90_RS05880	COG1132	(ABC) transporter
JQN90_RS05885	COG1132	(ABC) transporter
JQN90_RS05900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JQN90_RS05910	COG0613	PHP domain protein
JQN90_RS05935	COG3480	Lon protease (S16) C-terminal proteolytic domain
JQN90_RS05955	COG0351	phosphomethylpyrimidine kinase
JQN90_RS05960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JQN90_RS05980	COG3250	beta-galactosidase activity
JQN90_RS05995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JQN90_RS06040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JQN90_RS06045	COG2884	Cell division ATP-binding protein ftsE
JQN90_RS06050	COG2177	Part of the ABC transporter FtsEX involved in
JQN90_RS06055	COG1705	Flagellar rod assembly protein muramidase FlgJ
JQN90_RS06055	COG3942	CHAP domain
JQN90_RS06065	COG0564	pseudouridine synthase activity
JQN90_RS06125	COG3878	Protein conserved in bacteria
JQN90_RS06135	COG1621	beta-fructofuranosidase activity
JQN90_RS06140	COG0587	DNA-directed DNA polymerase activity
JQN90_RS06155	COG4716	Myosin-crossreactive antigen
JQN90_RS06170	COG0656	L-ascorbic acid biosynthetic process
JQN90_RS06250	COG1643	Atp-dependent helicase
JQN90_RS06255	COG2813	Specifically methylates the guanine in position
JQN90_RS06265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JQN90_RS06295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JQN90_RS06320	COG0768	penicillin binding
JQN90_RS06330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JQN90_RS06420	COG0601	transmembrane transport
JQN90_RS06425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JQN90_RS06435	COG0006	proline dipeptidase activity
JQN90_RS06445	COG0285	dihydrofolate synthase activity
JQN90_RS06450	COG1196	nuclear chromosome segregation
JQN90_RS06455	COG1794	racemase activity, acting on amino acids and derivatives
JQN90_RS06480	COG1595	DNA-templated transcription, initiation
JQN90_RS06490	COG2017	converts alpha-aldose to the beta-anomer
JQN90_RS06505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JQN90_RS06525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JQN90_RS06555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JQN90_RS06565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JQN90_RS06570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JQN90_RS06580	COG1104	cysteine desulfurase activity
JQN90_RS06585	COG1217	gtp-binding protein TYPA
JQN90_RS06600	COG0287	Prephenate dehydrogenase
JQN90_RS06640	COG0708	Exodeoxyribonuclease III
JQN90_RS06700	COG1011	Hydrolase
JQN90_RS06710	COG0560	Phosphoserine phosphatase
JQN90_RS06715	COG1222	aaa ATPase
JQN90_RS06720	COG4122	O-methyltransferase activity
JQN90_RS06750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JQN90_RS06790	COG0714	Associated with various cellular activities
JQN90_RS06805	COG1278	Cold shock
JQN90_RS06825	COG0745	RESPONSE REGULATOR receiver
JQN90_RS06830	COG2205	protein histidine kinase activity
JQN90_RS06835	COG1278	Cold shock
JQN90_RS06870	COG1196	nuclear chromosome segregation
JQN90_RS06895	COG1126	abc transporter atp-binding protein
JQN90_RS06900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JQN90_RS06905	COG0765	amino acid transport
JQN90_RS06910	COG0765	amino acid transport
JQN90_RS06915	COG2326	polyphosphate kinase activity
JQN90_RS06930	COG2814	Major facilitator Superfamily
JQN90_RS06955	COG1122	ATPase activity
JQN90_RS07045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JQN90_RS07065	COG1136	(ABC) transporter
JQN90_RS07090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JQN90_RS07120	COG1682	transport, permease protein
JQN90_RS07125	COG1134	teichoic acid transport
JQN90_RS07150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JQN90_RS07185	COG1760	l-serine dehydratase
JQN90_RS07195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JQN90_RS07220	COG1674	ftsk spoiiie
JQN90_RS07225	COG1316	TRANSCRIPTIONal
JQN90_RS07255	COG1040	competence protein
JQN90_RS07265	COG2205	protein histidine kinase activity
JQN90_RS07270	COG0745	RESPONSE REGULATOR receiver
JQN90_RS07295	COG1121	(ABC) transporter
JQN90_RS07310	COG0539	negative regulation of cytoplasmic translation
JQN90_RS07330	COG0469	pyruvate kinase activity
JQN90_RS07335	COG0494	nUDIX hydrolase
JQN90_RS07355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JQN90_RS07360	COG0494	nUDIX hydrolase
JQN90_RS07380	COG4974	Belongs to the 'phage' integrase family
JQN90_RS07385	COG3340	Belongs to the peptidase S51 family
JQN90_RS07395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JQN90_RS07400	COG0857	belongs to the CobB CobQ family
JQN90_RS07400	COG0280	phosphate acetyltransferase
JQN90_RS07405	COG4868	Belongs to the UPF0371 family
JQN90_RS07440	COG0488	(ABC) transporter
JQN90_RS07465	COG0582	viral genome integration into host DNA
JQN90_RS07490	COG0306	phosphate transporter
JQN90_RS07500	COG2197	response regulator
JQN90_RS07505	COG4585	Histidine kinase
JQN90_RS07515	COG1131	(ABC) transporter
JQN90_RS07580	COG1335	isochorismatase
JQN90_RS07615	COG2755	lipolytic protein G-D-S-L family
JQN90_RS07615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JQN90_RS07645	COG2755	lipolytic protein G-D-S-L family
JQN90_RS07645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JQN90_RS07695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JQN90_RS07725	COG0719	Fe-S assembly protein
JQN90_RS07730	COG0396	ATPase activity
JQN90_RS07745	COG2151	metal-sulfur cluster biosynthetic enzyme
JQN90_RS07770	COG0537	adenosine 5'-monophosphoramidase activity
JQN90_RS07800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JQN90_RS07825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JQN90_RS07845	COG2860	membrane
JQN90_RS07870	COG0436	Aminotransferase
JQN90_RS07880	COG0070	glutamate synthase
JQN90_RS07880	COG0069	glutamate synthase activity
JQN90_RS07880	COG0067	glutamate synthase
JQN90_RS07895	COG0297	glycogen (starch) synthase activity
JQN90_RS07900	COG1119	ATPase activity
JQN90_RS07905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JQN90_RS07920	COG2826	transposase and inactivated derivatives, IS30 family
JQN90_RS07925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JQN90_RS07940	COG0210	DNA helicase
JQN90_RS07965	COG2962	Rard protein
JQN90_RS07975	COG1073	alpha beta
JQN90_RS07985	COG2062	phosphohistidine phosphatase, SixA
JQN90_RS07995	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JQN90_RS08020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JQN90_RS08025	COG0284	orotidine-5'-phosphate decarboxylase activity
JQN90_RS08030	COG0543	2 iron, 2 sulfur cluster binding
JQN90_RS08035	COG0167	dihydroorotate dehydrogenase activity
JQN90_RS08050	COG1063	alcohol dehydrogenase
JQN90_RS08070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JQN90_RS08080	COG4221	oxidoreductase activity
JQN90_RS08100	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
JQN90_RS08115	COG4106	trans-aconitate 2-methyltransferase activity
JQN90_RS08125	COG3226	Transcriptional regulator
JQN90_RS08135	COG0583	DNA-binding transcription factor activity
JQN90_RS08265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JQN90_RS08280	COG0133	tryptophan synthase activity
JQN90_RS08295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JQN90_RS08320	COG0045	succinate-CoA ligase (ADP-forming) activity
JQN90_RS08330	COG1862	Preprotein translocase
JQN90_RS08365	COG1301	dicarboxylic acid transport
JQN90_RS08430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JQN90_RS08435	COG3619	membrane
JQN90_RS08440	COG1114	Component of the transport system for branched-chain amino acids
JQN90_RS08465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JQN90_RS08490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JQN90_RS08515	COG0745	RESPONSE REGULATOR receiver
JQN90_RS08520	COG2205	protein histidine kinase activity
JQN90_RS08525	COG1876	peptidase activity
JQN90_RS08530	COG0488	(ABC) transporter
JQN90_RS08550	COG1940	carbohydrate kinase activity
JQN90_RS08555	COG1940	carbohydrate kinase activity
JQN90_RS08565	COG0395	ABC-type sugar transport system, permease component
JQN90_RS08570	COG1175	transmembrane transport
JQN90_RS08635	COG1022	Amp-dependent synthetase and ligase
JQN90_RS08645	COG0516	GMP reductase activity
JQN90_RS08660	COG1022	Amp-dependent synthetase and ligase
JQN90_RS08690	COG0802	atpase or kinase
JQN90_RS08715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JQN90_RS08725	COG0406	alpha-ribazole phosphatase activity
JQN90_RS08755	COG3189	MarR family transcriptional regulator
JQN90_RS08775	COG1051	belongs to the nudix hydrolase family
JQN90_RS08800	COG2135	peptidase activity
JQN90_RS08840	COG2249	NAD(P)H dehydrogenase (quinone) activity
JQN90_RS08915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JQN90_RS08945	COG1131	(ABC) transporter
JQN90_RS08955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JQN90_RS08960	COG0497	DNA recombination
JQN90_RS08970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JQN90_RS08975	COG0569	domain protein
JQN90_RS08990	COG0647	UMP catabolic process
JQN90_RS09020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JQN90_RS09105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JQN90_RS09110	COG1136	(ABC) transporter
JQN90_RS09115	COG0390	transport system, permease component
JQN90_RS09135	COG2233	PERMEase
JQN90_RS09155	COG0583	DNA-binding transcription factor activity
JQN90_RS09165	COG1442	glycosyl transferase family 8
JQN90_RS09165	COG1216	Glycosyl transferase, family 2
JQN90_RS09185	COG0242	peptide deformylase activity