locus-tag	class	description
BBTM_RS00030	COG0714	Associated with various cellular activities
BBTM_RS00045	COG1278	Cold shock
BBTM_RS00065	COG0745	RESPONSE REGULATOR receiver
BBTM_RS00070	COG2205	protein histidine kinase activity
BBTM_RS00075	COG1278	Cold shock
BBTM_RS00135	COG1126	abc transporter atp-binding protein
BBTM_RS00145	COG0765	amino acid transport
BBTM_RS00150	COG0765	amino acid transport
BBTM_RS00155	COG2326	polyphosphate kinase activity
BBTM_RS00170	COG2814	Major facilitator Superfamily
BBTM_RS00195	COG1122	ATPase activity
BBTM_RS00255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBTM_RS00275	COG1136	(ABC) transporter
BBTM_RS00300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BBTM_RS00325	COG1682	transport, permease protein
BBTM_RS00330	COG1134	teichoic acid transport
BBTM_RS00350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBTM_RS00355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBTM_RS00390	COG1760	l-serine dehydratase
BBTM_RS00420	COG1674	ftsk spoiiie
BBTM_RS00425	COG1316	TRANSCRIPTIONal
BBTM_RS00455	COG1040	competence protein
BBTM_RS00465	COG2205	protein histidine kinase activity
BBTM_RS00470	COG0745	RESPONSE REGULATOR receiver
BBTM_RS00495	COG1121	(ABC) transporter
BBTM_RS00510	COG0539	negative regulation of cytoplasmic translation
BBTM_RS00530	COG0469	pyruvate kinase activity
BBTM_RS00535	COG0494	nUDIX hydrolase
BBTM_RS00555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBTM_RS00560	COG0494	nUDIX hydrolase
BBTM_RS00585	COG3340	Belongs to the peptidase S51 family
BBTM_RS00595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBTM_RS00600	COG0280	phosphate acetyltransferase
BBTM_RS00600	COG0857	belongs to the CobB CobQ family
BBTM_RS00620	COG0270	DNA (cytosine-5-)-methyltransferase activity
BBTM_RS00640	COG0306	phosphate transporter
BBTM_RS00650	COG2197	response regulator
BBTM_RS00655	COG4585	Histidine kinase
BBTM_RS00665	COG1131	(ABC) transporter
BBTM_RS00735	COG1335	isochorismatase
BBTM_RS00770	COG2755	lipolytic protein G-D-S-L family
BBTM_RS00770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BBTM_RS00790	COG1136	(ABC) transporter
BBTM_RS00790	COG0577	efflux transmembrane transporter activity
BBTM_RS00800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BBTM_RS00800	COG2755	lipolytic protein G-D-S-L family
BBTM_RS00850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBTM_RS00880	COG0719	Fe-S assembly protein
BBTM_RS00885	COG0396	ATPase activity
BBTM_RS00900	COG2151	metal-sulfur cluster biosynthetic enzyme
BBTM_RS00925	COG0537	adenosine 5'-monophosphoramidase activity
BBTM_RS00955	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BBTM_RS00985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBTM_RS01005	COG2860	membrane
BBTM_RS01025	COG0436	Aminotransferase
BBTM_RS01035	COG0067	glutamate synthase
BBTM_RS01035	COG0069	glutamate synthase activity
BBTM_RS01035	COG0070	glutamate synthase
BBTM_RS01050	COG0297	glycogen (starch) synthase activity
BBTM_RS01055	COG1119	ATPase activity
BBTM_RS01060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BBTM_RS01075	COG2826	transposase and inactivated derivatives, IS30 family
BBTM_RS01080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBTM_RS01095	COG0210	DNA helicase
BBTM_RS01110	COG3328	transposase activity
BBTM_RS01125	COG3328	transposase activity
BBTM_RS01140	COG2962	Rard protein
BBTM_RS01150	COG1073	alpha beta
BBTM_RS01160	COG2062	phosphohistidine phosphatase, SixA
BBTM_RS01170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BBTM_RS01195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBTM_RS01200	COG0284	orotidine-5'-phosphate decarboxylase activity
BBTM_RS01205	COG0543	2 iron, 2 sulfur cluster binding
BBTM_RS01210	COG0167	dihydroorotate dehydrogenase activity
BBTM_RS01225	COG1063	alcohol dehydrogenase
BBTM_RS01245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBTM_RS01255	COG4221	oxidoreductase activity
BBTM_RS01275	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BBTM_RS01290	COG4106	trans-aconitate 2-methyltransferase activity
BBTM_RS01300	COG3226	Transcriptional regulator
BBTM_RS01310	COG0583	DNA-binding transcription factor activity
BBTM_RS01370	COG1803	Methylglyoxal synthase
BBTM_RS01460	COG0133	tryptophan synthase activity
BBTM_RS01475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBTM_RS01500	COG0045	succinate-CoA ligase (ADP-forming) activity
BBTM_RS01510	COG1862	Preprotein translocase
BBTM_RS01545	COG1301	dicarboxylic acid transport
BBTM_RS01615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBTM_RS01620	COG3619	membrane
BBTM_RS01625	COG1114	Component of the transport system for branched-chain amino acids
BBTM_RS01650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBTM_RS01675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBTM_RS01695	COG0577	efflux transmembrane transporter activity
BBTM_RS01695	COG1136	(ABC) transporter
BBTM_RS01700	COG0745	RESPONSE REGULATOR receiver
BBTM_RS01710	COG3328	transposase activity
BBTM_RS01720	COG1876	peptidase activity
BBTM_RS01725	COG0488	(ABC) transporter
BBTM_RS01745	COG1940	carbohydrate kinase activity
BBTM_RS01750	COG1940	carbohydrate kinase activity
BBTM_RS01760	COG0395	ABC-type sugar transport system, permease component
BBTM_RS01765	COG1175	transmembrane transport
BBTM_RS01835	COG1022	Amp-dependent synthetase and ligase
BBTM_RS01845	COG0516	GMP reductase activity
BBTM_RS01860	COG1022	Amp-dependent synthetase and ligase
BBTM_RS01880	COG0456	acetyltransferase
BBTM_RS01890	COG0802	atpase or kinase
BBTM_RS01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBTM_RS01920	COG0598	Magnesium transport protein CorA
BBTM_RS01925	COG0406	alpha-ribazole phosphatase activity
BBTM_RS01955	COG3189	MarR family transcriptional regulator
BBTM_RS02010	COG2135	peptidase activity
BBTM_RS02050	COG2249	NAD(P)H dehydrogenase (quinone) activity
BBTM_RS02105	COG0799	negative regulation of ribosome biogenesis
BBTM_RS02125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBTM_RS02165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBTM_RS02170	COG0497	DNA recombination
BBTM_RS02185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBTM_RS02190	COG0569	domain protein
BBTM_RS02205	COG0647	UMP catabolic process
BBTM_RS02240	COG3328	transposase activity
BBTM_RS02345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBTM_RS02350	COG1136	(ABC) transporter
BBTM_RS02355	COG0390	transport system, permease component
BBTM_RS02365	COG3328	transposase activity
BBTM_RS02375	COG2233	PERMEase
BBTM_RS02395	COG0583	DNA-binding transcription factor activity
BBTM_RS02405	COG1216	Glycosyl transferase, family 2
BBTM_RS02405	COG1442	glycosyl transferase family 8
BBTM_RS02430	COG0242	peptide deformylase activity
BBTM_RS02445	COG3328	transposase activity
BBTM_RS02530	COG0758	DNA mediated transformation
BBTM_RS02560	COG0012	GTP binding
BBTM_RS02565	COG0436	Aminotransferase
BBTM_RS02575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBTM_RS02580	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBTM_RS02580	COG0022	dehydrogenase e1 component
BBTM_RS02585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BBTM_RS02605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBTM_RS02620	COG2197	response regulator
BBTM_RS02625	COG0671	phosphoesterase, PA-phosphatase related
BBTM_RS02630	COG1136	(ABC) transporter
BBTM_RS02630	COG0577	efflux transmembrane transporter activity
BBTM_RS02635	COG1136	(ABC) transporter
BBTM_RS02640	COG2873	o-acetylhomoserine
BBTM_RS02655	COG1053	succinate dehydrogenase
BBTM_RS02690	COG1611	Belongs to the LOG family
BBTM_RS02695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBTM_RS02700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BBTM_RS02755	COG1882	Formate acetyltransferase
BBTM_RS02770	COG1473	amidohydrolase
BBTM_RS02780	COG0561	phosphatase activity
BBTM_RS02805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBTM_RS02830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBTM_RS02840	COG3655	Transcriptional regulator
BBTM_RS02860	COG0187	DNA topoisomerase II activity
BBTM_RS02865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBTM_RS02875	COG0142	geranyltranstransferase activity
BBTM_RS02895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBTM_RS02905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBTM_RS02930	COG1396	sequence-specific DNA binding
BBTM_RS02935	COG1058	Belongs to the CinA family
BBTM_RS02935	COG1546	Belongs to the CinA family
BBTM_RS02940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBTM_RS02965	COG2357	RelA SpoT domain protein
BBTM_RS02975	COG0670	Belongs to the BI1 family
BBTM_RS02990	COG2197	response regulator
BBTM_RS03090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBTM_RS03130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBTM_RS03150	COG1368	sulfuric ester hydrolase activity
BBTM_RS03155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BBTM_RS03160	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BBTM_RS03175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BBTM_RS03180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBTM_RS03190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBTM_RS03200	COG0701	Predicted permease
BBTM_RS03220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BBTM_RS03225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BBTM_RS03235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBTM_RS03250	COG1355	regulation of microtubule-based process
BBTM_RS03260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBTM_RS03275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBTM_RS03280	COG0531	amino acid
BBTM_RS03300	COG0514	ATP-dependent DNA helicase (RecQ)
BBTM_RS03355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBTM_RS03390	COG0395	ABC-type sugar transport system, permease component
BBTM_RS03420	COG1950	PFAM Membrane protein of
BBTM_RS03425	COG1012	belongs to the aldehyde dehydrogenase family
BBTM_RS03445	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBTM_RS03450	COG1929	Belongs to the glycerate kinase type-1 family
BBTM_RS03455	COG1136	(ABC) transporter
BBTM_RS03455	COG0577	efflux transmembrane transporter activity
BBTM_RS03460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BBTM_RS03475	COG0667	Aldo Keto reductase
BBTM_RS03480	COG2176	DNA-directed DNA polymerase activity
BBTM_RS03490	COG0024	Methionine aminopeptidase
BBTM_RS03500	COG3590	peptidase
BBTM_RS03525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBTM_RS03550	COG0366	Alpha amylase catalytic
BBTM_RS03560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBTM_RS03565	COG0009	L-threonylcarbamoyladenylate synthase
BBTM_RS03600	COG4975	Glucose uptake
BBTM_RS03605	COG0673	inositol 2-dehydrogenase activity
BBTM_RS03610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBTM_RS03625	COG3328	transposase activity
BBTM_RS03630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBTM_RS03640	COG3328	transposase activity
BBTM_RS03655	COG0513	Belongs to the DEAD box helicase family
BBTM_RS03665	COG0577	efflux transmembrane transporter activity
BBTM_RS03680	COG2873	o-acetylhomoserine
BBTM_RS03690	COG2814	Major facilitator Superfamily
BBTM_RS03695	COG1940	carbohydrate kinase activity
BBTM_RS03700	COG0488	(ABC) transporter
BBTM_RS03705	COG0477	Major facilitator Superfamily
BBTM_RS03750	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BBTM_RS03790	COG1946	Acyl-CoA thioesterase
BBTM_RS03805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBTM_RS03810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BBTM_RS03820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBTM_RS03825	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BBTM_RS03850	COG1215	transferase activity, transferring glycosyl groups
BBTM_RS03860	COG1216	Glycosyl transferase, family 2
BBTM_RS03865	COG1454	alcohol dehydrogenase
BBTM_RS03885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBTM_RS03915	COG3250	beta-galactosidase activity
BBTM_RS03925	COG1609	Transcriptional regulator
BBTM_RS03930	COG2205	protein histidine kinase activity
BBTM_RS03935	COG0745	RESPONSE REGULATOR receiver
BBTM_RS03950	COG1136	(ABC) transporter
BBTM_RS03970	COG0577	efflux transmembrane transporter activity
BBTM_RS03980	COG1136	(ABC) transporter
BBTM_RS03990	COG1687	branched-chain amino acid
BBTM_RS04005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BBTM_RS04020	COG0589	response to stress
BBTM_RS04030	COG1388	LysM domain
BBTM_RS04030	COG3942	CHAP domain
BBTM_RS04035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BBTM_RS04045	COG5002	protein histidine kinase activity
BBTM_RS04050	COG0704	Plays a role in the regulation of phosphate uptake
BBTM_RS04070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBTM_RS04080	COG2814	Major facilitator Superfamily
BBTM_RS04110	COG2197	response regulator
BBTM_RS04120	COG0363	glucosamine-6-phosphate deaminase activity
BBTM_RS04160	COG1525	nuclease
BBTM_RS04160	COG0737	Belongs to the 5'-nucleotidase family
BBTM_RS04160	COG4085	toxin activity
BBTM_RS04165	COG1803	Methylglyoxal synthase
BBTM_RS04165	COG1597	lipid kinase activity
BBTM_RS04175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBTM_RS04175	COG2190	(PTS) system
BBTM_RS04175	COG1263	PTS System
BBTM_RS04200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBTM_RS04210	COG0328	RNA-DNA hybrid ribonuclease activity
BBTM_RS04235	COG0196	riboflavin kinase activity
BBTM_RS04280	COG2308	Evidence 4 Homologs of previously reported genes of
BBTM_RS04330	COG0201	protein transport
BBTM_RS04390	COG0255	Belongs to the universal ribosomal protein uL29 family
BBTM_RS04450	COG3527	Alpha-acetolactate decarboxylase
BBTM_RS04455	COG1012	belongs to the aldehyde dehydrogenase family
BBTM_RS04455	COG1454	alcohol dehydrogenase
BBTM_RS04490	COG1739	Uncharacterized protein family UPF0029
BBTM_RS04505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBTM_RS04515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BBTM_RS04520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBTM_RS04550	COG0714	Associated with various cellular activities
BBTM_RS04575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBTM_RS04620	COG2755	lipolytic protein G-D-S-L family
BBTM_RS04620	COG0657	acetylesterase activity
BBTM_RS04625	COG4409	exo-alpha-(2->6)-sialidase activity
BBTM_RS04635	COG2252	PERMEase
BBTM_RS04650	COG0581	inorganic phosphate transmembrane transporter activity
BBTM_RS04665	COG0745	RESPONSE REGULATOR receiver
BBTM_RS04670	COG5002	protein histidine kinase activity
BBTM_RS04680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBTM_RS04695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBTM_RS04715	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BBTM_RS04730	COG0826	peptidase U32
BBTM_RS04740	COG0656	L-ascorbic acid biosynthetic process
BBTM_RS04755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBTM_RS04760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBTM_RS04775	COG1704	LemA family
BBTM_RS04780	COG1609	Transcriptional regulator
BBTM_RS04825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBTM_RS04830	COG4770	biotin carboxylase activity
BBTM_RS04835	COG1268	BioY protein
BBTM_RS04840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BBTM_RS04840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BBTM_RS04865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BBTM_RS04900	COG0356	it plays a direct role in the translocation of protons across the membrane
BBTM_RS04940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBTM_RS04955	COG0745	RESPONSE REGULATOR receiver
BBTM_RS04965	COG0747	negative chemotaxis
BBTM_RS04980	COG1605	Chorismate mutase
BBTM_RS04980	COG0287	Prephenate dehydrogenase
BBTM_RS04985	COG1522	sequence-specific DNA binding
BBTM_RS04990	COG0436	Aminotransferase
BBTM_RS05040	COG1131	(ABC) transporter
BBTM_RS05055	COG1322	Protein conserved in bacteria
BBTM_RS05060	COG1937	Protein conserved in bacteria
BBTM_RS05085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBTM_RS05090	COG0305	Participates in initiation and elongation during chromosome replication
BBTM_RS05100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BBTM_RS05125	COG1309	transcriptional regulator
BBTM_RS05130	COG1216	Glycosyl transferase, family 2
BBTM_RS05165	COG1132	(ABC) transporter
BBTM_RS05225	COG0561	phosphatase activity
BBTM_RS05230	COG2723	6-phospho-beta-galactosidase activity
BBTM_RS05245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BBTM_RS05260	COG1609	Transcriptional regulator
BBTM_RS05275	COG0577	efflux transmembrane transporter activity
BBTM_RS05280	COG0577	efflux transmembrane transporter activity
BBTM_RS05290	COG3470	protein probably involved in high-affinity Fe2 transport
BBTM_RS05295	COG0672	)-iron permease
BBTM_RS05315	COG0477	Major facilitator Superfamily
BBTM_RS05400	COG1136	(ABC) transporter
BBTM_RS05400	COG0577	efflux transmembrane transporter activity
BBTM_RS05415	COG1113	amino acid transport
BBTM_RS05420	COG3250	beta-galactosidase activity
BBTM_RS05440	COG0477	Major facilitator Superfamily
BBTM_RS05485	COG0497	DNA recombination
BBTM_RS05490	COG0191	fructose-bisphosphate aldolase activity
BBTM_RS05575	COG2217	Heavy metal translocating P-type atpase
BBTM_RS05585	COG0343	queuine tRNA-ribosyltransferase activity
BBTM_RS05655	COG0494	nUDIX hydrolase
BBTM_RS05660	COG0513	Belongs to the DEAD box helicase family
BBTM_RS05675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBTM_RS05675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBTM_RS05740	COG0768	penicillin binding
BBTM_RS05745	COG0515	serine threonine protein kinase
BBTM_RS05800	COG0058	SHG alpha-glucan phosphorylase activity
BBTM_RS05830	COG2814	Major facilitator Superfamily
BBTM_RS05860	COG1215	transferase activity, transferring glycosyl groups
BBTM_RS05915	COG3328	transposase activity
BBTM_RS05925	COG1088	dTDP-glucose 4,6-dehydratase activity
BBTM_RS05940	COG3328	transposase activity
BBTM_RS05955	COG1088	dTDP-glucose 4,6-dehydratase activity
BBTM_RS05980	COG0180	Tryptophanyl-tRNA synthetase
BBTM_RS06000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BBTM_RS06020	COG0288	reversible hydration of carbon dioxide
BBTM_RS06030	COG1253	flavin adenine dinucleotide binding
BBTM_RS06040	COG0783	Belongs to the Dps family
BBTM_RS06060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBTM_RS06065	COG1609	Transcriptional regulator
BBTM_RS06090	COG3534	alpha-L-arabinofuranosidase
BBTM_RS06095	COG1970	mechanosensitive ion channel activity
BBTM_RS06105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBTM_RS06145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBTM_RS06150	COG0187	DNA topoisomerase II activity
BBTM_RS06165	COG0592	DNA-directed DNA polymerase activity
BBTM_RS06195	COG1847	R3H domain protein
BBTM_RS06205	COG1192	Involved in chromosome partitioning
BBTM_RS06215	COG0492	ferredoxin-NADP+ reductase activity
BBTM_RS06235	COG0617	tRNA 3'-terminal CCA addition
BBTM_RS06255	COG3583	domain protein
BBTM_RS06280	COG3842	ATPase activity
BBTM_RS06285	COG2826	transposase and inactivated derivatives, IS30 family
BBTM_RS06315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBTM_RS06335	COG0025	NhaP-type Na H and K H
BBTM_RS06345	COG0590	tRNA wobble adenosine to inosine editing
BBTM_RS06345	COG0037	tRNA processing
BBTM_RS06350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBTM_RS06355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBTM_RS06375	COG3231	kanamycin kinase activity
BBTM_RS06420	COG1609	Transcriptional regulator
BBTM_RS06445	COG0789	Transcriptional regulator
BBTM_RS06470	COG0586	Pfam SNARE associated Golgi protein
BBTM_RS06500	COG1609	Transcriptional regulator
BBTM_RS06510	COG0084	hydrolase, TatD family'
BBTM_RS06535	COG1136	(ABC) transporter
BBTM_RS06575	COG1216	Glycosyl transferase, family 2
BBTM_RS06580	COG3328	transposase activity
BBTM_RS06600	COG0406	alpha-ribazole phosphatase activity
BBTM_RS06600	COG0494	nUDIX hydrolase
BBTM_RS06650	COG1597	lipid kinase activity
BBTM_RS06705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBTM_RS06720	COG1404	Belongs to the peptidase S8 family
BBTM_RS06735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBTM_RS06735	COG1754	DNA topoisomerase type I activity
BBTM_RS06745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BBTM_RS06755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBTM_RS06755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBTM_RS06760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBTM_RS06785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BBTM_RS06820	COG2977	Belongs to the P-Pant transferase superfamily
BBTM_RS06875	COG0667	Aldo Keto reductase
BBTM_RS06900	COG1132	(ABC) transporter
BBTM_RS06950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBTM_RS06960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBTM_RS07015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBTM_RS07035	COG0167	dihydroorotate dehydrogenase activity
BBTM_RS07040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBTM_RS07050	COG1309	transcriptional regulator
BBTM_RS07110	COG1028	Short-chain dehydrogenase reductase Sdr
BBTM_RS07125	COG0251	oxidation-reduction process
BBTM_RS07130	COG0584	glycerophosphoryl diester phosphodiesterase
BBTM_RS07145	COG2190	(PTS) system
BBTM_RS07145	COG1263	PTS System
BBTM_RS07145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBTM_RS07150	COG2190	(PTS) system
BBTM_RS07150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBTM_RS07150	COG1263	PTS System
BBTM_RS07155	COG0460	homoserine dehydrogenase
BBTM_RS07160	COG0083	homoserine kinase activity
BBTM_RS07180	COG1136	(ABC) transporter
BBTM_RS07195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBTM_RS07200	COG1530	ribonuclease E activity
BBTM_RS07230	COG0436	Aminotransferase
BBTM_RS07240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBTM_RS07270	COG0584	glycerophosphoryl diester phosphodiesterase
BBTM_RS07275	COG0366	Alpha amylase catalytic
BBTM_RS07340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBTM_RS07390	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBTM_RS07420	COG0436	Aminotransferase
BBTM_RS07445	COG1022	Amp-dependent synthetase and ligase
BBTM_RS07510	COG0789	Transcriptional regulator
BBTM_RS07515	COG2270	Major facilitator Superfamily
BBTM_RS07555	COG1301	dicarboxylic acid transport
BBTM_RS07560	COG0742	ribosomal rna small subunit methyltransferase
BBTM_RS07570	COG0071	Belongs to the small heat shock protein (HSP20) family
BBTM_RS07585	COG1837	Belongs to the UPF0109 family
BBTM_RS07600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBTM_RS07630	COG0519	Catalyzes the synthesis of GMP from XMP
BBTM_RS07635	COG0488	(ABC) transporter
BBTM_RS07675	COG0440	acetolactate synthase activity
BBTM_RS07745	COG1285	pathogenesis
BBTM_RS07755	COG1116	anion transmembrane transporter activity
BBTM_RS07770	COG3623	hexulose-6-phosphate isomerase
BBTM_RS07785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBTM_RS07790	COG1609	Transcriptional regulator
BBTM_RS07820	COG1609	Transcriptional regulator
BBTM_RS07835	COG0656	L-ascorbic acid biosynthetic process
BBTM_RS07850	COG2814	Major facilitator Superfamily
BBTM_RS07865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBTM_RS07910	COG0095	Lipoate-protein ligase
BBTM_RS07915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBTM_RS07920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBTM_RS07925	COG1902	pentaerythritol trinitrate reductase activity
BBTM_RS07930	COG0167	dihydroorotate dehydrogenase activity
BBTM_RS07935	COG1349	DNA-binding transcription factor activity
BBTM_RS07945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BBTM_RS07950	COG0477	Major facilitator Superfamily
BBTM_RS07970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBTM_RS08030	COG0714	Associated with various cellular activities
BBTM_RS08040	COG0515	serine threonine protein kinase
BBTM_RS08040	COG2815	serine threonine protein kinase
BBTM_RS08095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BBTM_RS08105	COG1404	Belongs to the peptidase S8 family
BBTM_RS08130	COG0436	Aminotransferase
BBTM_RS08135	COG0248	Ppx GppA phosphatase
BBTM_RS08140	COG0248	Ppx GppA phosphatase
BBTM_RS08155	COG2210	Belongs to the sulfur carrier protein TusA family
BBTM_RS08180	COG1722	exodeoxyribonuclease VII activity
BBTM_RS08185	COG1570	exodeoxyribonuclease VII activity
BBTM_RS08190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBTM_RS08190	COG1328	CTP reductase activity
BBTM_RS08195	COG0602	queuosine metabolic process
BBTM_RS08260	COG1132	(ABC) transporter
BBTM_RS08265	COG1132	(ABC) transporter
BBTM_RS08280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBTM_RS08290	COG0613	PHP domain protein
BBTM_RS08315	COG3480	Lon protease (S16) C-terminal proteolytic domain
BBTM_RS08330	COG3328	transposase activity
BBTM_RS08340	COG0351	phosphomethylpyrimidine kinase
BBTM_RS08345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBTM_RS08365	COG3250	beta-galactosidase activity
BBTM_RS08380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBTM_RS08425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBTM_RS08430	COG2884	Cell division ATP-binding protein ftsE
BBTM_RS08435	COG2177	Part of the ABC transporter FtsEX involved in
BBTM_RS08440	COG3942	CHAP domain
BBTM_RS08440	COG1705	Flagellar rod assembly protein muramidase FlgJ
BBTM_RS08450	COG0564	pseudouridine synthase activity
BBTM_RS08505	COG3878	Protein conserved in bacteria
BBTM_RS08515	COG1621	beta-fructofuranosidase activity
BBTM_RS08520	COG0587	DNA-directed DNA polymerase activity
BBTM_RS08535	COG4716	Myosin-crossreactive antigen
BBTM_RS08550	COG0656	L-ascorbic acid biosynthetic process
BBTM_RS08635	COG1643	Atp-dependent helicase
BBTM_RS08640	COG2813	Specifically methylates the guanine in position
BBTM_RS08650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBTM_RS08680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBTM_RS08705	COG0768	penicillin binding
BBTM_RS08715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBTM_RS08805	COG0601	transmembrane transport
BBTM_RS08810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBTM_RS08820	COG0006	proline dipeptidase activity
BBTM_RS08835	COG1196	nuclear chromosome segregation
BBTM_RS08840	COG1794	racemase activity, acting on amino acids and derivatives
BBTM_RS08865	COG1595	DNA-templated transcription, initiation
BBTM_RS08875	COG2017	converts alpha-aldose to the beta-anomer
BBTM_RS08890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBTM_RS08910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BBTM_RS08940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BBTM_RS08950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BBTM_RS08955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BBTM_RS08965	COG1104	cysteine desulfurase activity
BBTM_RS08970	COG1217	gtp-binding protein TYPA
BBTM_RS08985	COG0287	Prephenate dehydrogenase
BBTM_RS09025	COG0708	Exodeoxyribonuclease III
BBTM_RS09085	COG1011	Hydrolase
BBTM_RS09095	COG0560	Phosphoserine phosphatase
BBTM_RS09100	COG1222	aaa ATPase
BBTM_RS09105	COG4122	O-methyltransferase activity
BBTM_RS09135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily