locus-tag	class	description
HMPREF9228_RS00010	COG0592	DNA-directed DNA polymerase activity
HMPREF9228_RS00025	COG0187	DNA topoisomerase II activity
HMPREF9228_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9228_RS00040	COG1609	Transcriptional regulator
HMPREF9228_RS00050	COG3250	beta-galactosidase activity
HMPREF9228_RS00060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMPREF9228_RS00095	COG0783	Belongs to the Dps family
HMPREF9228_RS00100	COG1253	flavin adenine dinucleotide binding
HMPREF9228_RS00165	COG3706	GGDEF domain
HMPREF9228_RS00165	COG4251	negative regulation of phosphorylation
HMPREF9228_RS00165	COG5001	Diguanylate cyclase
HMPREF9228_RS00165	COG2203	Gaf domain
HMPREF9228_RS00185	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS00190	COG1175	transmembrane transport
HMPREF9228_RS00200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HMPREF9228_RS00205	COG4608	Belongs to the ABC transporter superfamily
HMPREF9228_RS00220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HMPREF9228_RS00230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMPREF9228_RS00245	COG0180	Tryptophanyl-tRNA synthetase
HMPREF9228_RS00255	COG2197	response regulator
HMPREF9228_RS00275	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF9228_RS00315	COG0515	serine threonine protein kinase
HMPREF9228_RS00320	COG0768	penicillin binding
HMPREF9228_RS00355	COG0071	Belongs to the small heat shock protein (HSP20) family
HMPREF9228_RS00360	COG0697	spore germination
HMPREF9228_RS00370	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HMPREF9228_RS00375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HMPREF9228_RS00395	COG1216	Glycosyl transferase, family 2
HMPREF9228_RS00425	COG0343	queuine tRNA-ribosyltransferase activity
HMPREF9228_RS00455	COG0697	spore germination
HMPREF9228_RS00460	COG0191	fructose-bisphosphate aldolase activity
HMPREF9228_RS00500	COG1609	Transcriptional regulator
HMPREF9228_RS00505	COG0477	Major facilitator Superfamily
HMPREF9228_RS00530	COG0366	Alpha amylase catalytic
HMPREF9228_RS00535	COG1609	Transcriptional regulator
HMPREF9228_RS00570	COG1175	transmembrane transport
HMPREF9228_RS00575	COG3833	ABC-type maltose transport systems, permease component
HMPREF9228_RS00590	COG1523	belongs to the glycosyl hydrolase 13 family
HMPREF9228_RS00610	COG0789	Transcriptional regulator
HMPREF9228_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9228_RS00630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9228_RS00635	COG0586	Pfam SNARE associated Golgi protein
HMPREF9228_RS00675	COG1309	transcriptional regulator
HMPREF9228_RS00745	COG0527	aspartate kinase activity
HMPREF9228_RS00780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HMPREF9228_RS00785	COG1176	ABC-type spermidine putrescine transport system, permease component I
HMPREF9228_RS00795	COG3842	ATPase activity
HMPREF9228_RS00825	COG1940	carbohydrate kinase activity
HMPREF9228_RS00830	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HMPREF9228_RS00840	COG0747	negative chemotaxis
HMPREF9228_RS00850	COG0444	Belongs to the ABC transporter superfamily
HMPREF9228_RS00855	COG4608	Belongs to the ABC transporter superfamily
HMPREF9228_RS00860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF9228_RS00885	COG2186	Transcriptional regulator
HMPREF9228_RS00910	COG1754	DNA topoisomerase type I activity
HMPREF9228_RS00910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF9228_RS00920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF9228_RS00935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF9228_RS01020	COG1733	regulation of RNA biosynthetic process
HMPREF9228_RS01025	COG2910	NAD(P)H-binding
HMPREF9228_RS01035	COG0477	Major facilitator Superfamily
HMPREF9228_RS01040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF9228_RS01045	COG3321	synthase
HMPREF9228_RS01045	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9228_RS01045	COG0604	alcohol dehydrogenase
HMPREF9228_RS01055	COG2977	Belongs to the P-Pant transferase superfamily
HMPREF9228_RS01080	COG2801	Transposase and inactivated derivatives
HMPREF9228_RS01115	COG0672	)-iron permease
HMPREF9228_RS01120	COG3470	protein probably involved in high-affinity Fe2 transport
HMPREF9228_RS01135	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS01140	COG1136	(ABC) transporter
HMPREF9228_RS01170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HMPREF9228_RS01175	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF9228_RS01205	COG1442	glycosyl transferase family 8
HMPREF9228_RS01205	COG1216	Glycosyl transferase, family 2
HMPREF9228_RS01210	COG1309	transcriptional regulator
HMPREF9228_RS01230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HMPREF9228_RS01240	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF9228_RS01245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF9228_RS01250	COG3442	glutamine amidotransferase
HMPREF9228_RS01275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF9228_RS01325	COG1131	(ABC) transporter
HMPREF9228_RS01365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF9228_RS01375	COG1937	Protein conserved in bacteria
HMPREF9228_RS01395	COG1131	(ABC) transporter
HMPREF9228_RS01470	COG2182	Extracellular solute-binding protein
HMPREF9228_RS01480	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS01520	COG0745	RESPONSE REGULATOR receiver
HMPREF9228_RS01535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HMPREF9228_RS01560	COG0356	it plays a direct role in the translocation of protons across the membrane
HMPREF9228_RS01595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HMPREF9228_RS01635	COG0251	oxidation-reduction process
HMPREF9228_RS01670	COG3842	ATPase activity
HMPREF9228_RS01685	COG1027	Aspartate ammonia-lyase
HMPREF9228_RS01695	COG0730	response to heat
HMPREF9228_RS01700	COG0641	radical SAM
HMPREF9228_RS01705	COG1609	Transcriptional regulator
HMPREF9228_RS01710	COG3119	arylsulfatase activity
HMPREF9228_RS01725	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS01730	COG1373	ATPase (AAA superfamily
HMPREF9228_RS01735	COG3328	transposase activity
HMPREF9228_RS01750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMPREF9228_RS01765	COG0475	glutathione-regulated potassium exporter activity
HMPREF9228_RS01765	COG0569	domain protein
HMPREF9228_RS01815	COG1136	(ABC) transporter
HMPREF9228_RS01825	COG1704	LemA family
HMPREF9228_RS01850	COG1957	nucleoside hydrolase
HMPREF9228_RS01860	COG1653	transport
HMPREF9228_RS01865	COG1175	transmembrane transport
HMPREF9228_RS01870	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS01895	COG1837	Belongs to the UPF0109 family
HMPREF9228_RS01925	COG0505	Belongs to the CarA family
HMPREF9228_RS01930	COG0488	(ABC) transporter
HMPREF9228_RS01935	COG1487	ribonuclease activity
HMPREF9228_RS01945	COG0440	acetolactate synthase activity
HMPREF9228_RS01985	COG0667	Aldo Keto reductase
HMPREF9228_RS02035	COG1116	anion transmembrane transporter activity
HMPREF9228_RS02055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMPREF9228_RS02060	COG1609	Transcriptional regulator
HMPREF9228_RS02070	COG0477	Major facilitator Superfamily
HMPREF9228_RS02070	COG2814	Major facilitator Superfamily
HMPREF9228_RS02080	COG4988	ABC transporter
HMPREF9228_RS02090	COG1653	transport
HMPREF9228_RS02095	COG1175	transmembrane transport
HMPREF9228_RS02100	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS02115	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HMPREF9228_RS02120	COG0656	L-ascorbic acid biosynthetic process
HMPREF9228_RS02135	COG2814	Major facilitator Superfamily
HMPREF9228_RS02150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMPREF9228_RS02160	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9228_RS02180	COG0438	transferase activity, transferring glycosyl groups
HMPREF9228_RS02185	COG0438	transferase activity, transferring glycosyl groups
HMPREF9228_RS02200	COG0463	Glycosyl transferase, family 2
HMPREF9228_RS02205	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HMPREF9228_RS02305	COG0560	Phosphoserine phosphatase
HMPREF9228_RS02310	COG0586	Pfam SNARE associated Golgi protein
HMPREF9228_RS02320	COG1011	Hydrolase
HMPREF9228_RS02335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9228_RS02335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9228_RS02335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9228_RS02340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMPREF9228_RS02350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF9228_RS02355	COG4122	O-methyltransferase activity
HMPREF9228_RS02385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF9228_RS02425	COG0714	Associated with various cellular activities
HMPREF9228_RS02440	COG1278	Cold shock
HMPREF9228_RS02460	COG0745	RESPONSE REGULATOR receiver
HMPREF9228_RS02465	COG2205	protein histidine kinase activity
HMPREF9228_RS02470	COG1278	Cold shock
HMPREF9228_RS02480	COG0589	response to stress
HMPREF9228_RS02495	COG0477	Major facilitator Superfamily
HMPREF9228_RS02510	COG1196	nuclear chromosome segregation
HMPREF9228_RS02530	COG1126	abc transporter atp-binding protein
HMPREF9228_RS02535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF9228_RS02540	COG0765	amino acid transport
HMPREF9228_RS02545	COG0765	amino acid transport
HMPREF9228_RS02555	COG1279	arginine transmembrane transporter activity
HMPREF9228_RS02560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF9228_RS02565	COG2326	polyphosphate kinase activity
HMPREF9228_RS02570	COG4581	dead DEAH box helicase
HMPREF9228_RS02590	COG2814	Major facilitator Superfamily
HMPREF9228_RS02595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPREF9228_RS02665	COG2197	response regulator
HMPREF9228_RS02675	COG2271	Major facilitator Superfamily
HMPREF9228_RS02685	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF9228_RS02685	COG0351	phosphomethylpyrimidine kinase
HMPREF9228_RS02690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF9228_RS02715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HMPREF9228_RS02750	COG0587	DNA-directed DNA polymerase activity
HMPREF9228_RS02765	COG4716	Myosin-crossreactive antigen
HMPREF9228_RS02785	COG4948	Mandelate Racemase Muconate Lactonizing
HMPREF9228_RS02800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF9228_RS02810	COG0656	L-ascorbic acid biosynthetic process
HMPREF9228_RS02865	COG1643	Atp-dependent helicase
HMPREF9228_RS02875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF9228_RS02905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPREF9228_RS02930	COG0768	penicillin binding
HMPREF9228_RS02940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF9228_RS02980	COG0738	Major facilitator superfamily
HMPREF9228_RS02995	COG1940	carbohydrate kinase activity
HMPREF9228_RS03000	COG1940	carbohydrate kinase activity
HMPREF9228_RS03020	COG0006	proline dipeptidase activity
HMPREF9228_RS03025	COG0285	dihydrofolate synthase activity
HMPREF9228_RS03030	COG1196	nuclear chromosome segregation
HMPREF9228_RS03050	COG1595	DNA-templated transcription, initiation
HMPREF9228_RS03060	COG2017	converts alpha-aldose to the beta-anomer
HMPREF9228_RS03065	COG2017	converts alpha-aldose to the beta-anomer
HMPREF9228_RS03075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMPREF9228_RS03095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMPREF9228_RS03110	COG3835	regulator
HMPREF9228_RS03115	COG2610	gluconate transmembrane transporter activity
HMPREF9228_RS03120	COG1929	Belongs to the glycerate kinase type-1 family
HMPREF9228_RS03140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMPREF9228_RS03150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HMPREF9228_RS03155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HMPREF9228_RS03170	COG0477	Major facilitator Superfamily
HMPREF9228_RS03180	COG4591	ABC-type transport system involved in lipoprotein release permease component
HMPREF9228_RS03180	COG1136	(ABC) transporter
HMPREF9228_RS03190	COG1217	gtp-binding protein TYPA
HMPREF9228_RS03205	COG0287	Prephenate dehydrogenase
HMPREF9228_RS03215	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS03220	COG1136	(ABC) transporter
HMPREF9228_RS03220	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS03230	COG4166	transmembrane transport
HMPREF9228_RS03235	COG0601	transmembrane transport
HMPREF9228_RS03240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9228_RS03250	COG0708	Exodeoxyribonuclease III
HMPREF9228_RS03275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF9228_RS03305	COG2357	RelA SpoT domain protein
HMPREF9228_RS03335	COG1546	Belongs to the CinA family
HMPREF9228_RS03335	COG1058	Belongs to the CinA family
HMPREF9228_RS03340	COG1396	sequence-specific DNA binding
HMPREF9228_RS03360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMPREF9228_RS03370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMPREF9228_RS03390	COG0142	geranyltranstransferase activity
HMPREF9228_RS03400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF9228_RS03405	COG0187	DNA topoisomerase II activity
HMPREF9228_RS03415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9228_RS03420	COG1201	RNA secondary structure unwinding
HMPREF9228_RS03435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9228_RS03460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMPREF9228_RS03500	COG1653	transport
HMPREF9228_RS03505	COG1175	transmembrane transport
HMPREF9228_RS03510	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS03570	COG0406	alpha-ribazole phosphatase activity
HMPREF9228_RS03575	COG0598	Magnesium transport protein CorA
HMPREF9228_RS03580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF9228_RS03605	COG0802	atpase or kinase
HMPREF9228_RS03615	COG0456	acetyltransferase
HMPREF9228_RS03630	COG2197	response regulator
HMPREF9228_RS03635	COG4585	Histidine kinase
HMPREF9228_RS03705	COG0516	GMP reductase activity
HMPREF9228_RS03745	COG0575	Belongs to the CDS family
HMPREF9228_RS03755	COG0693	protein deglycase activity
HMPREF9228_RS03790	COG3189	MarR family transcriptional regulator
HMPREF9228_RS03800	COG0833	amino acid
HMPREF9228_RS03825	COG4181	ATPase activity
HMPREF9228_RS03840	COG0745	RESPONSE REGULATOR receiver
HMPREF9228_RS03885	COG0833	amino acid
HMPREF9228_RS03895	COG2135	peptidase activity
HMPREF9228_RS03900	COG0133	tryptophan synthase activity
HMPREF9228_RS03915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF9228_RS03950	COG1716	ATPase activity
HMPREF9228_RS04015	COG1187	pseudouridine synthase activity
HMPREF9228_RS04020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF9228_RS04040	COG0045	succinate-CoA ligase (ADP-forming) activity
HMPREF9228_RS04140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMPREF9228_RS04155	COG0436	Aminotransferase
HMPREF9228_RS04175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPREF9228_RS04200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF9228_RS04235	COG4221	oxidoreductase activity
HMPREF9228_RS04240	COG0488	(ABC) transporter
HMPREF9228_RS04255	COG0583	DNA-binding transcription factor activity
HMPREF9228_RS04275	COG0167	dihydroorotate dehydrogenase activity
HMPREF9228_RS04280	COG0543	2 iron, 2 sulfur cluster binding
HMPREF9228_RS04285	COG0284	orotidine-5'-phosphate decarboxylase activity
HMPREF9228_RS04290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF9228_RS04315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HMPREF9228_RS04325	COG0588	phosphoglycerate mutase activity
HMPREF9228_RS04350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMPREF9228_RS04360	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HMPREF9228_RS04365	COG1073	alpha beta
HMPREF9228_RS04430	COG1119	ATPase activity
HMPREF9228_RS04435	COG0297	glycogen (starch) synthase activity
HMPREF9228_RS04450	COG4166	transmembrane transport
HMPREF9228_RS04460	COG0069	glutamate synthase activity
HMPREF9228_RS04460	COG0067	glutamate synthase
HMPREF9228_RS04460	COG0070	glutamate synthase
HMPREF9228_RS04490	COG2860	membrane
HMPREF9228_RS04500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF9228_RS04525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HMPREF9228_RS04530	COG1022	Amp-dependent synthetase and ligase
HMPREF9228_RS04550	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF9228_RS04555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HMPREF9228_RS04575	COG2151	metal-sulfur cluster biosynthetic enzyme
HMPREF9228_RS04585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMPREF9228_RS04590	COG0396	ATPase activity
HMPREF9228_RS04595	COG0719	Fe-S assembly protein
HMPREF9228_RS04615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HMPREF9228_RS04695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMPREF9228_RS04705	COG1136	(ABC) transporter
HMPREF9228_RS04705	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS04735	COG3655	Transcriptional regulator
HMPREF9228_RS04755	COG1335	isochorismatase
HMPREF9228_RS04760	COG3340	Belongs to the peptidase S51 family
HMPREF9228_RS04805	COG1131	(ABC) transporter
HMPREF9228_RS04810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF9228_RS04815	COG4585	Histidine kinase
HMPREF9228_RS04820	COG2197	response regulator
HMPREF9228_RS04830	COG0306	phosphate transporter
HMPREF9228_RS04835	COG0366	Alpha amylase catalytic
HMPREF9228_RS04840	COG0513	Belongs to the DEAD box helicase family
HMPREF9228_RS04845	COG2233	PERMEase
HMPREF9228_RS04885	COG0058	SHG alpha-glucan phosphorylase activity
HMPREF9228_RS04890	COG2814	Major facilitator Superfamily
HMPREF9228_RS04895	COG1309	transcriptional regulator
HMPREF9228_RS04940	COG3177	Filamentation induced by cAMP protein fic
HMPREF9228_RS04945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMPREF9228_RS04965	COG0012	GTP binding
HMPREF9228_RS04970	COG0765	amino acid transport
HMPREF9228_RS04975	COG0765	amino acid transport
HMPREF9228_RS04980	COG1126	abc transporter atp-binding protein
HMPREF9228_RS04985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMPREF9228_RS04990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF9228_RS05005	COG2197	response regulator
HMPREF9228_RS05010	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS05010	COG1136	(ABC) transporter
HMPREF9228_RS05015	COG1136	(ABC) transporter
HMPREF9228_RS05020	COG2873	o-acetylhomoserine
HMPREF9228_RS05050	COG0758	DNA mediated transformation
HMPREF9228_RS05055	COG1053	succinate dehydrogenase
HMPREF9228_RS05070	COG1611	Belongs to the LOG family
HMPREF9228_RS05075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HMPREF9228_RS05080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HMPREF9228_RS05140	COG1882	Formate acetyltransferase
HMPREF9228_RS05155	COG1473	amidohydrolase
HMPREF9228_RS05160	COG2011	ABC-type metal ion transport system permease component
HMPREF9228_RS05190	COG0406	alpha-ribazole phosphatase activity
HMPREF9228_RS05195	COG0799	negative regulation of ribosome biogenesis
HMPREF9228_RS05235	COG0857	belongs to the CobB CobQ family
HMPREF9228_RS05235	COG0280	phosphate acetyltransferase
HMPREF9228_RS05240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMPREF9228_RS05265	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9228_RS05290	COG1051	belongs to the nudix hydrolase family
HMPREF9228_RS05295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMPREF9228_RS05315	COG0494	nUDIX hydrolase
HMPREF9228_RS05320	COG0469	pyruvate kinase activity
HMPREF9228_RS05340	COG0539	negative regulation of cytoplasmic translation
HMPREF9228_RS05355	COG1121	(ABC) transporter
HMPREF9228_RS05360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9228_RS05380	COG0745	RESPONSE REGULATOR receiver
HMPREF9228_RS05385	COG2205	protein histidine kinase activity
HMPREF9228_RS05425	COG1316	TRANSCRIPTIONal
HMPREF9228_RS05450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMPREF9228_RS05460	COG1760	l-serine dehydratase
HMPREF9228_RS05495	COG0667	Aldo Keto reductase
HMPREF9228_RS05510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HMPREF9228_RS05510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMPREF9228_RS05520	COG1472	Belongs to the glycosyl hydrolase 3 family
HMPREF9228_RS05525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF9228_RS05575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9228_RS05580	COG0497	DNA recombination
HMPREF9228_RS05590	COG0569	domain protein
HMPREF9228_RS05635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMPREF9228_RS05640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HMPREF9228_RS05665	COG4115	mRNA cleavage
HMPREF9228_RS05740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF9228_RS05750	COG1122	ATPase activity
HMPREF9228_RS05755	COG4721	ABC-type cobalt transport system, permease component
HMPREF9228_RS05760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF9228_RS05805	COG1122	ATPase activity
HMPREF9228_RS05820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF9228_RS05900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HMPREF9228_RS05935	COG0626	cystathionine gamma-synthase activity
HMPREF9228_RS05955	COG2176	DNA-directed DNA polymerase activity
HMPREF9228_RS05965	COG0284	orotidine-5'-phosphate decarboxylase activity
HMPREF9228_RS05990	COG1132	(ABC) transporter
HMPREF9228_RS05995	COG0390	transport system, permease component
HMPREF9228_RS06025	COG0110	maltose O-acetyltransferase activity
HMPREF9228_RS06030	COG0110	maltose O-acetyltransferase activity
HMPREF9228_RS06050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMPREF9228_RS06055	COG0583	DNA-binding transcription factor activity
HMPREF9228_RS06060	COG0477	Major facilitator Superfamily
HMPREF9228_RS06080	COG1609	Transcriptional regulator
HMPREF9228_RS06100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9228_RS06105	COG0601	transmembrane transport
HMPREF9228_RS06110	COG0747	negative chemotaxis
HMPREF9228_RS06120	COG2755	lipolytic protein G-D-S-L family
HMPREF9228_RS06120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HMPREF9228_RS06130	COG0745	RESPONSE REGULATOR receiver
HMPREF9228_RS06145	COG1063	alcohol dehydrogenase
HMPREF9228_RS06175	COG0583	DNA-binding transcription factor activity
HMPREF9228_RS06205	COG0385	Bile acid
HMPREF9228_RS06225	COG0436	Aminotransferase
HMPREF9228_RS06240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF9228_RS06300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF9228_RS06320	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF9228_RS06340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF9228_RS06345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF9228_RS06350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMPREF9228_RS06360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HMPREF9228_RS06375	COG0701	Predicted permease
HMPREF9228_RS06400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF9228_RS06420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HMPREF9228_RS06425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF9228_RS06430	COG0604	alcohol dehydrogenase
HMPREF9228_RS06435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF9228_RS06440	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS06440	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS06450	COG1136	(ABC) transporter
HMPREF9228_RS06450	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS06470	COG0366	Alpha amylase catalytic
HMPREF9228_RS06475	COG1609	Transcriptional regulator
HMPREF9228_RS06510	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMPREF9228_RS06515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF9228_RS06530	COG0358	DNA primase activity
HMPREF9228_RS06540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF9228_RS06545	COG0531	amino acid
HMPREF9228_RS06560	COG0514	ATP-dependent DNA helicase (RecQ)
HMPREF9228_RS06565	COG0626	cystathionine gamma-synthase activity
HMPREF9228_RS06575	COG4608	Belongs to the ABC transporter superfamily
HMPREF9228_RS06585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9228_RS06590	COG0601	transmembrane transport
HMPREF9228_RS06615	COG1653	transport
HMPREF9228_RS06625	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS06630	COG1175	transmembrane transport
HMPREF9228_RS06635	COG1609	Transcriptional regulator
HMPREF9228_RS06640	COG0564	pseudouridine synthase activity
HMPREF9228_RS06650	COG1126	abc transporter atp-binding protein
HMPREF9228_RS06675	COG1388	LysM domain
HMPREF9228_RS06675	COG3942	CHAP domain
HMPREF9228_RS06680	COG2177	Part of the ABC transporter FtsEX involved in
HMPREF9228_RS06685	COG2884	Cell division ATP-binding protein ftsE
HMPREF9228_RS06690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF9228_RS06715	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMPREF9228_RS06735	COG0210	DNA helicase
HMPREF9228_RS06750	COG0714	Associated with various cellular activities
HMPREF9228_RS06785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HMPREF9228_RS06805	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF9228_RS06815	COG1349	DNA-binding transcription factor activity
HMPREF9228_RS06820	COG0167	dihydroorotate dehydrogenase activity
HMPREF9228_RS06825	COG1902	pentaerythritol trinitrate reductase activity
HMPREF9228_RS06830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF9228_RS06830	COG4499	WXG100 protein secretion system (Wss), protein YukC
HMPREF9228_RS06835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HMPREF9228_RS06840	COG0095	Lipoate-protein ligase
HMPREF9228_RS06895	COG0489	protein tyrosine kinase activity
HMPREF9228_RS06950	COG4974	Belongs to the 'phage' integrase family
HMPREF9228_RS06980	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMPREF9228_RS06985	COG1518	maintenance of DNA repeat elements
HMPREF9228_RS07025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9228_RS07030	COG1869	D-ribose catabolic process
HMPREF9228_RS07040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9228_RS07045	COG1129	ABC transporter
HMPREF9228_RS07065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9228_RS07070	COG1979	alcohol dehydrogenase
HMPREF9228_RS07075	COG0546	phosphoglycolate phosphatase activity
HMPREF9228_RS07085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMPREF9228_RS07090	COG0135	phosphoribosylanthranilate isomerase activity
HMPREF9228_RS07095	COG1122	ATPase activity
HMPREF9228_RS07120	COG1132	(ABC) transporter
HMPREF9228_RS07125	COG1132	(ABC) transporter
HMPREF9228_RS07195	COG1309	transcriptional regulator
HMPREF9228_RS07210	COG0602	queuosine metabolic process
HMPREF9228_RS07215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF9228_RS07215	COG1328	CTP reductase activity
HMPREF9228_RS07220	COG1570	exodeoxyribonuclease VII activity
HMPREF9228_RS07225	COG1722	exodeoxyribonuclease VII activity
HMPREF9228_RS07230	COG2249	NAD(P)H dehydrogenase (quinone) activity
HMPREF9228_RS07235	COG1022	Amp-dependent synthetase and ligase
HMPREF9228_RS07260	COG0248	Ppx GppA phosphatase
HMPREF9228_RS07265	COG0436	Aminotransferase
HMPREF9228_RS07335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMPREF9228_RS07350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF9228_RS07355	COG0009	L-threonylcarbamoyladenylate synthase
HMPREF9228_RS07405	COG2814	Major facilitator Superfamily
HMPREF9228_RS07415	COG0242	peptide deformylase activity
HMPREF9228_RS07435	COG1940	carbohydrate kinase activity
HMPREF9228_RS07460	COG1946	Acyl-CoA thioesterase
HMPREF9228_RS07470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMPREF9228_RS07485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF9228_RS07490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HMPREF9228_RS07515	COG1215	transferase activity, transferring glycosyl groups
HMPREF9228_RS07525	COG0463	Glycosyl transferase, family 2
HMPREF9228_RS07530	COG1454	alcohol dehydrogenase
HMPREF9228_RS07535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HMPREF9228_RS07575	COG1192	Involved in chromosome partitioning
HMPREF9228_RS07585	COG0488	(ABC) transporter
HMPREF9228_RS07610	COG1569	PIN domain
HMPREF9228_RS07635	COG3942	CHAP domain
HMPREF9228_RS07635	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF9228_RS07690	COG3843	relaxase mobilization nuclease domain protein
HMPREF9228_RS07710	COG1475	DNA binding
HMPREF9228_RS07740	COG3250	beta-galactosidase activity
HMPREF9228_RS07745	COG1609	Transcriptional regulator
HMPREF9228_RS07780	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS07795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMPREF9228_RS07815	COG0589	response to stress
HMPREF9228_RS07820	COG3103	Sh3 type 3 domain protein
HMPREF9228_RS07820	COG1388	LysM domain
HMPREF9228_RS07820	COG0791	NLP P60 protein
HMPREF9228_RS07830	COG1705	Flagellar rod assembly protein muramidase FlgJ
HMPREF9228_RS07830	COG3942	CHAP domain
HMPREF9228_RS07835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HMPREF9228_RS07845	COG5002	protein histidine kinase activity
HMPREF9228_RS07860	COG1575	Belongs to the MenA family. Type 1 subfamily
HMPREF9228_RS07865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF9228_RS07875	COG2814	Major facilitator Superfamily
HMPREF9228_RS07910	COG2197	response regulator
HMPREF9228_RS07930	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS07935	COG1175	transmembrane transport
HMPREF9228_RS07955	COG1803	Methylglyoxal synthase
HMPREF9228_RS07955	COG1597	lipid kinase activity
HMPREF9228_RS07985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9228_RS07990	COG0328	RNA-DNA hybrid ribonuclease activity
HMPREF9228_RS08010	COG0196	riboflavin kinase activity
HMPREF9228_RS08040	COG1609	Transcriptional regulator
HMPREF9228_RS08055	COG2308	Evidence 4 Homologs of previously reported genes of
HMPREF9228_RS08155	COG0255	Belongs to the universal ribosomal protein uL29 family
HMPREF9228_RS08205	COG3527	Alpha-acetolactate decarboxylase
HMPREF9228_RS08215	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF9228_RS08215	COG1454	alcohol dehydrogenase
HMPREF9228_RS08225	COG1063	alcohol dehydrogenase
HMPREF9228_RS08280	COG1739	Uncharacterized protein family UPF0029
HMPREF9228_RS08285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPREF9228_RS08295	COG2723	6-phospho-beta-galactosidase activity
HMPREF9228_RS08305	COG1175	transmembrane transport
HMPREF9228_RS08315	COG1609	Transcriptional regulator
HMPREF9228_RS08335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF9228_RS08350	COG0531	amino acid
HMPREF9228_RS08355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HMPREF9228_RS08395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMPREF9228_RS08440	COG2252	PERMEase
HMPREF9228_RS08465	COG0745	RESPONSE REGULATOR receiver
HMPREF9228_RS08470	COG5002	protein histidine kinase activity
HMPREF9228_RS08475	COG0477	Major facilitator Superfamily
HMPREF9228_RS08485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMPREF9228_RS08490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HMPREF9228_RS08500	COG3250	beta-galactosidase activity
HMPREF9228_RS08505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9228_RS08520	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS08525	COG1175	transmembrane transport
HMPREF9228_RS08530	COG1653	transport
HMPREF9228_RS08545	COG3579	cysteine-type endopeptidase activity
HMPREF9228_RS08560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMPREF9228_RS08575	COG0826	peptidase U32
HMPREF9228_RS08585	COG0742	ribosomal rna small subunit methyltransferase
HMPREF9228_RS08600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HMPREF9228_RS08600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HMPREF9228_RS08605	COG2270	Major facilitator Superfamily
HMPREF9228_RS08670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HMPREF9228_RS08675	COG4770	biotin carboxylase activity
HMPREF9228_RS08680	COG1268	BioY protein
HMPREF9228_RS08715	COG0250	Participates in transcription elongation, termination and antitermination
HMPREF9228_RS08720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPREF9228_RS08730	COG0436	Aminotransferase
HMPREF9228_RS08760	COG1530	ribonuclease E activity
HMPREF9228_RS08765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF9228_RS08775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF9228_RS08795	COG4948	Mandelate Racemase Muconate Lactonizing
HMPREF9228_RS08800	COG1609	Transcriptional regulator
HMPREF9228_RS08830	COG0083	homoserine kinase activity
HMPREF9228_RS08835	COG0460	homoserine dehydrogenase
HMPREF9228_RS08840	COG2190	(PTS) system
HMPREF9228_RS08840	COG1263	PTS System
HMPREF9228_RS08840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9228_RS08845	COG2190	(PTS) system
HMPREF9228_RS08845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9228_RS08845	COG1263	PTS System
HMPREF9228_RS08860	COG1309	transcriptional regulator
HMPREF9228_RS08870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF9228_RS08875	COG0446	pyridine nucleotide-disulphide oxidoreductase
HMPREF9228_RS08885	COG0765	amino acid transport
HMPREF9228_RS08900	COG1126	abc transporter atp-binding protein
HMPREF9228_RS08905	COG0167	dihydroorotate dehydrogenase activity
HMPREF9228_RS08935	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HMPREF9228_RS08940	COG0406	alpha-ribazole phosphatase activity
HMPREF9228_RS08940	COG0494	nUDIX hydrolase
HMPREF9228_RS08970	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF9228_RS08990	COG0179	Fumarylacetoacetate (FAA) hydrolase
HMPREF9228_RS09015	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9228_RS09020	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9228_RS09025	COG1129	ABC transporter
HMPREF9228_RS09035	COG1070	Carbohydrate kinase
HMPREF9228_RS09050	COG1216	Glycosyl transferase, family 2
HMPREF9228_RS09050	COG1442	glycosyl transferase family 8
HMPREF9228_RS09060	COG1368	sulfuric ester hydrolase activity
HMPREF9228_RS09065	COG1216	Glycosyl transferase, family 2
HMPREF9228_RS09065	COG0438	transferase activity, transferring glycosyl groups
HMPREF9228_RS09095	COG1088	dTDP-glucose 4,6-dehydratase activity
HMPREF9228_RS09115	COG1376	ErfK ybiS ycfS ynhG family protein
HMPREF9228_RS09130	COG1316	TRANSCRIPTIONal
HMPREF9228_RS09135	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS09140	COG1129	ABC transporter
HMPREF9228_RS09160	COG0084	hydrolase, TatD family'
HMPREF9228_RS09165	COG1132	(ABC) transporter
HMPREF9228_RS09170	COG1132	(ABC) transporter
HMPREF9228_RS09190	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS09195	COG1175	transmembrane transport
HMPREF9228_RS09205	COG1609	Transcriptional regulator
HMPREF9228_RS09210	COG1874	Beta-galactosidase
HMPREF9228_RS09240	COG4166	transmembrane transport
HMPREF9228_RS09260	COG3579	cysteine-type endopeptidase activity
HMPREF9228_RS09310	COG1846	Transcriptional regulator
HMPREF9228_RS09315	COG1113	amino acid transport
HMPREF9228_RS09325	COG1136	(ABC) transporter
HMPREF9228_RS09325	COG0577	efflux transmembrane transporter activity
HMPREF9228_RS09330	COG1113	amino acid transport
HMPREF9228_RS09350	COG1609	Transcriptional regulator
HMPREF9228_RS09360	COG0588	phosphoglycerate mutase activity
HMPREF9228_RS09420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HMPREF9228_RS09425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMPREF9228_RS09430	COG0366	Alpha amylase catalytic
HMPREF9228_RS09435	COG0395	ABC-type sugar transport system, permease component
HMPREF9228_RS09440	COG1175	transmembrane transport
HMPREF9228_RS09460	COG0590	tRNA wobble adenosine to inosine editing
HMPREF9228_RS09460	COG0037	tRNA processing
HMPREF9228_RS09465	COG0025	NhaP-type Na H and K H
HMPREF9228_RS09470	COG0730	response to heat
HMPREF9228_RS09495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF9228_RS09505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9228_RS09505	COG2190	(PTS) system
HMPREF9228_RS09505	COG1263	PTS System
HMPREF9228_RS09510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9228_RS09510	COG1263	PTS System
HMPREF9228_RS09520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMPREF9228_RS09560	COG1609	Transcriptional regulator
HMPREF9228_RS09565	COG1879	ABC-type sugar transport system periplasmic component
HMPREF9228_RS09575	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9228_RS09585	COG2801	Transposase and inactivated derivatives
HMPREF9228_RS09585	COG3415	Transposase
HMPREF9228_RS09590	COG3842	ATPase activity
HMPREF9228_RS09595	COG2188	Transcriptional regulator
HMPREF9228_RS09610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9228_RS09615	COG1215	transferase activity, transferring glycosyl groups
HMPREF9228_RS09635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF9228_RS09655	COG1472	Belongs to the glycosyl hydrolase 3 family
HMPREF9228_RS09670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HMPREF9228_RS09675	COG1472	Belongs to the glycosyl hydrolase 3 family
HMPREF9228_RS09695	COG3583	domain protein
HMPREF9228_RS09715	COG0617	tRNA 3'-terminal CCA addition
HMPREF9228_RS09735	COG0492	ferredoxin-NADP+ reductase activity
HMPREF9228_RS09745	COG1192	Involved in chromosome partitioning
HMPREF9228_RS09755	COG1847	R3H domain protein