locus-tag	class	description
RY69_RS00030	COG0446	pyridine nucleotide-disulphide oxidoreductase
RY69_RS00035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RY69_RS00045	COG1309	transcriptional regulator
RY69_RS00055	COG0019	diaminopimelate decarboxylase activity
RY69_RS00060	COG1263	PTS System
RY69_RS00060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY69_RS00060	COG2190	(PTS) system
RY69_RS00065	COG1263	PTS System
RY69_RS00065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY69_RS00065	COG2190	(PTS) system
RY69_RS00070	COG0460	homoserine dehydrogenase
RY69_RS00075	COG0083	homoserine kinase activity
RY69_RS00105	COG1609	Transcriptional regulator
RY69_RS00110	COG4948	Mandelate Racemase Muconate Lactonizing
RY69_RS00130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RY69_RS00140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RY69_RS00145	COG1530	ribonuclease E activity
RY69_RS00175	COG0436	Aminotransferase
RY69_RS00185	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RY69_RS00190	COG0250	Participates in transcription elongation, termination and antitermination
RY69_RS00225	COG1268	BioY protein
RY69_RS00230	COG4770	biotin carboxylase activity
RY69_RS00235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RY69_RS00310	COG2270	Major facilitator Superfamily
RY69_RS00315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RY69_RS00315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RY69_RS00330	COG0742	ribosomal rna small subunit methyltransferase
RY69_RS00340	COG0826	peptidase U32
RY69_RS00355	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RY69_RS00370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY69_RS00375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY69_RS00380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RY69_RS00390	COG5002	protein histidine kinase activity
RY69_RS00395	COG0745	RESPONSE REGULATOR receiver
RY69_RS00420	COG2252	PERMEase
RY69_RS00500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RY69_RS00505	COG0531	amino acid
RY69_RS00520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RY69_RS00535	COG1609	Transcriptional regulator
RY69_RS00545	COG1175	transmembrane transport
RY69_RS00555	COG2723	6-phospho-beta-galactosidase activity
RY69_RS00565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY69_RS00570	COG1739	Uncharacterized protein family UPF0029
RY69_RS00625	COG1063	alcohol dehydrogenase
RY69_RS00635	COG1012	belongs to the aldehyde dehydrogenase family
RY69_RS00635	COG1454	alcohol dehydrogenase
RY69_RS00645	COG3527	Alpha-acetolactate decarboxylase
RY69_RS00695	COG0255	Belongs to the universal ribosomal protein uL29 family
RY69_RS00800	COG2308	Evidence 4 Homologs of previously reported genes of
RY69_RS00815	COG1609	Transcriptional regulator
RY69_RS00845	COG0196	riboflavin kinase activity
RY69_RS00865	COG0328	RNA-DNA hybrid ribonuclease activity
RY69_RS00870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RY69_RS00900	COG1597	lipid kinase activity
RY69_RS00900	COG1803	Methylglyoxal synthase
RY69_RS00920	COG1175	transmembrane transport
RY69_RS00925	COG0395	ABC-type sugar transport system, permease component
RY69_RS00945	COG2197	response regulator
RY69_RS00980	COG2814	Major facilitator Superfamily
RY69_RS00990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RY69_RS00995	COG1575	Belongs to the MenA family. Type 1 subfamily
RY69_RS01010	COG5002	protein histidine kinase activity
RY69_RS01020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RY69_RS01025	COG3942	CHAP domain
RY69_RS01025	COG1705	Flagellar rod assembly protein muramidase FlgJ
RY69_RS01035	COG0791	NLP P60 protein
RY69_RS01035	COG1388	LysM domain
RY69_RS01035	COG3103	Sh3 type 3 domain protein
RY69_RS01040	COG0589	response to stress
RY69_RS01060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RY69_RS01080	COG0577	efflux transmembrane transporter activity
RY69_RS01110	COG1609	Transcriptional regulator
RY69_RS01115	COG3250	beta-galactosidase activity
RY69_RS01135	COG2801	Transposase and inactivated derivatives
RY69_RS01160	COG3942	CHAP domain
RY69_RS01160	COG1705	Flagellar rod assembly protein muramidase FlgJ
RY69_RS01185	COG1569	PIN domain
RY69_RS01210	COG0488	(ABC) transporter
RY69_RS01220	COG1192	Involved in chromosome partitioning
RY69_RS01280	COG0745	RESPONSE REGULATOR receiver
RY69_RS01300	COG1136	(ABC) transporter
RY69_RS01310	COG1609	Transcriptional regulator
RY69_RS01315	COG1131	(ABC) transporter
RY69_RS01345	COG4133	protoheme IX ABC transporter activity
RY69_RS01360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RY69_RS01385	COG1192	Involved in chromosome partitioning
RY69_RS01430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RY69_RS01435	COG1454	alcohol dehydrogenase
RY69_RS01440	COG0463	Glycosyl transferase, family 2
RY69_RS01450	COG1215	transferase activity, transferring glycosyl groups
RY69_RS01475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RY69_RS01480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RY69_RS01495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RY69_RS01505	COG1946	Acyl-CoA thioesterase
RY69_RS01530	COG1940	carbohydrate kinase activity
RY69_RS01550	COG0242	peptide deformylase activity
RY69_RS01560	COG2814	Major facilitator Superfamily
RY69_RS01610	COG0009	L-threonylcarbamoyladenylate synthase
RY69_RS01615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RY69_RS01625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RY69_RS01655	COG1609	Transcriptional regulator
RY69_RS01665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RY69_RS01730	COG0436	Aminotransferase
RY69_RS01735	COG0248	Ppx GppA phosphatase
RY69_RS01755	COG1970	mechanosensitive ion channel activity
RY69_RS01760	COG1022	Amp-dependent synthetase and ligase
RY69_RS01765	COG2249	NAD(P)H dehydrogenase (quinone) activity
RY69_RS01770	COG1722	exodeoxyribonuclease VII activity
RY69_RS01775	COG1570	exodeoxyribonuclease VII activity
RY69_RS01780	COG1328	CTP reductase activity
RY69_RS01780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RY69_RS01785	COG0602	queuosine metabolic process
RY69_RS01800	COG1309	transcriptional regulator
RY69_RS01865	COG1132	(ABC) transporter
RY69_RS01870	COG1132	(ABC) transporter
RY69_RS01890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RY69_RS01940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RY69_RS01945	COG0560	Phosphoserine phosphatase
RY69_RS01950	COG0586	Pfam SNARE associated Golgi protein
RY69_RS01960	COG1011	Hydrolase
RY69_RS01975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY69_RS01975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY69_RS01975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY69_RS01980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RY69_RS01990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RY69_RS01995	COG4122	O-methyltransferase activity
RY69_RS02025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RY69_RS02070	COG0714	Associated with various cellular activities
RY69_RS02085	COG1278	Cold shock
RY69_RS02105	COG0745	RESPONSE REGULATOR receiver
RY69_RS02110	COG2205	protein histidine kinase activity
RY69_RS02115	COG1278	Cold shock
RY69_RS02125	COG0589	response to stress
RY69_RS02140	COG0477	Major facilitator Superfamily
RY69_RS02155	COG1196	nuclear chromosome segregation
RY69_RS02175	COG1126	abc transporter atp-binding protein
RY69_RS02180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY69_RS02185	COG0765	amino acid transport
RY69_RS02190	COG0765	amino acid transport
RY69_RS02200	COG1279	arginine transmembrane transporter activity
RY69_RS02205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RY69_RS02210	COG2326	polyphosphate kinase activity
RY69_RS02230	COG2814	Major facilitator Superfamily
RY69_RS02235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY69_RS02305	COG2197	response regulator
RY69_RS02315	COG2271	Major facilitator Superfamily
RY69_RS02325	COG0351	phosphomethylpyrimidine kinase
RY69_RS02325	COG0352	thiamine-phosphate diphosphorylase activity
RY69_RS02330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RY69_RS02355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RY69_RS02390	COG0587	DNA-directed DNA polymerase activity
RY69_RS02405	COG4716	Myosin-crossreactive antigen
RY69_RS02425	COG4948	Mandelate Racemase Muconate Lactonizing
RY69_RS02440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RY69_RS02445	COG4154	Belongs to the RbsD FucU family
RY69_RS02460	COG0656	L-ascorbic acid biosynthetic process
RY69_RS02510	COG2814	Major facilitator Superfamily
RY69_RS02515	COG1643	Atp-dependent helicase
RY69_RS02525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RY69_RS02555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY69_RS02580	COG0768	penicillin binding
RY69_RS02590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RY69_RS02640	COG1940	carbohydrate kinase activity
RY69_RS02645	COG1940	carbohydrate kinase activity
RY69_RS02665	COG0006	proline dipeptidase activity
RY69_RS02670	COG0285	dihydrofolate synthase activity
RY69_RS02675	COG1196	nuclear chromosome segregation
RY69_RS02695	COG1595	DNA-templated transcription, initiation
RY69_RS02705	COG2017	converts alpha-aldose to the beta-anomer
RY69_RS02710	COG2017	converts alpha-aldose to the beta-anomer
RY69_RS02720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RY69_RS02740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RY69_RS02755	COG1929	Belongs to the glycerate kinase type-1 family
RY69_RS02770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RY69_RS02775	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RY69_RS02785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RY69_RS02790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RY69_RS02800	COG1104	cysteine desulfurase activity
RY69_RS02805	COG0477	Major facilitator Superfamily
RY69_RS02810	COG1217	gtp-binding protein TYPA
RY69_RS02820	COG0077	Prephenate dehydratase
RY69_RS02820	COG1605	Chorismate mutase
RY69_RS02825	COG0287	Prephenate dehydrogenase
RY69_RS02840	COG4166	transmembrane transport
RY69_RS02845	COG0601	transmembrane transport
RY69_RS02850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RY69_RS02860	COG0708	Exodeoxyribonuclease III
RY69_RS02915	COG2357	RelA SpoT domain protein
RY69_RS02945	COG1058	Belongs to the CinA family
RY69_RS02945	COG1546	Belongs to the CinA family
RY69_RS02950	COG1396	sequence-specific DNA binding
RY69_RS02975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RY69_RS02985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RY69_RS03005	COG0142	geranyltranstransferase activity
RY69_RS03015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RY69_RS03020	COG0187	DNA topoisomerase II activity
RY69_RS03030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RY69_RS03035	COG1201	RNA secondary structure unwinding
RY69_RS03050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RY69_RS03075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RY69_RS03140	COG2963	transposase activity
RY69_RS03145	COG2801	Transposase and inactivated derivatives
RY69_RS03150	COG2801	Transposase and inactivated derivatives
RY69_RS03175	COG2963	transposase activity
RY69_RS03180	COG2801	Transposase and inactivated derivatives
RY69_RS03205	COG4974	Belongs to the 'phage' integrase family
RY69_RS03275	COG1653	transport
RY69_RS03280	COG1175	transmembrane transport
RY69_RS03285	COG0395	ABC-type sugar transport system, permease component
RY69_RS03335	COG0406	alpha-ribazole phosphatase activity
RY69_RS03340	COG0598	Magnesium transport protein CorA
RY69_RS03345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY69_RS03370	COG0802	atpase or kinase
RY69_RS03380	COG0456	acetyltransferase
RY69_RS03435	COG1192	Involved in chromosome partitioning
RY69_RS03570	COG3550	peptidyl-serine autophosphorylation
RY69_RS03585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RY69_RS03585	COG0551	DNA topoisomerase type I activity
RY69_RS03605	COG3942	CHAP domain
RY69_RS03675	COG0516	GMP reductase activity
RY69_RS03715	COG0575	Belongs to the CDS family
RY69_RS03725	COG0693	protein deglycase activity
RY69_RS03760	COG3189	MarR family transcriptional regulator
RY69_RS03770	COG0833	amino acid
RY69_RS03805	COG1120	ATPase activity
RY69_RS03820	COG1131	(ABC) transporter
RY69_RS03850	COG1131	(ABC) transporter
RY69_RS03895	COG4181	ATPase activity
RY69_RS03910	COG0745	RESPONSE REGULATOR receiver
RY69_RS03965	COG0833	amino acid
RY69_RS03975	COG2135	peptidase activity
RY69_RS03980	COG0133	tryptophan synthase activity
RY69_RS03995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RY69_RS04010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RY69_RS04030	COG1716	ATPase activity
RY69_RS04095	COG1187	pseudouridine synthase activity
RY69_RS04100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RY69_RS04120	COG0045	succinate-CoA ligase (ADP-forming) activity
RY69_RS04205	COG4974	Belongs to the 'phage' integrase family
RY69_RS04285	COG1475	DNA binding
RY69_RS04485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RY69_RS04500	COG0436	Aminotransferase
RY69_RS04515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RY69_RS04540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RY69_RS04560	COG1129	ABC transporter
RY69_RS04565	COG4221	oxidoreductase activity
RY69_RS04570	COG0488	(ABC) transporter
RY69_RS04585	COG0583	DNA-binding transcription factor activity
RY69_RS04605	COG0167	dihydroorotate dehydrogenase activity
RY69_RS04610	COG0543	2 iron, 2 sulfur cluster binding
RY69_RS04615	COG0284	orotidine-5'-phosphate decarboxylase activity
RY69_RS04620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RY69_RS04645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RY69_RS04655	COG0588	phosphoglycerate mutase activity
RY69_RS04675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RY69_RS04685	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RY69_RS04780	COG0561	phosphatase activity
RY69_RS04785	COG1119	ATPase activity
RY69_RS04790	COG0297	glycogen (starch) synthase activity
RY69_RS04805	COG4166	transmembrane transport
RY69_RS04820	COG0067	glutamate synthase
RY69_RS04820	COG0069	glutamate synthase activity
RY69_RS04820	COG0070	glutamate synthase
RY69_RS04845	COG2860	membrane
RY69_RS04855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RY69_RS04880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RY69_RS04885	COG1022	Amp-dependent synthetase and ligase
RY69_RS04910	COG0537	adenosine 5'-monophosphoramidase activity
RY69_RS04915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RY69_RS04935	COG2151	metal-sulfur cluster biosynthetic enzyme
RY69_RS04945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RY69_RS04950	COG0396	ATPase activity
RY69_RS04955	COG0719	Fe-S assembly protein
RY69_RS04975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RY69_RS05045	COG4974	Belongs to the 'phage' integrase family
RY69_RS05060	COG2233	PERMEase
RY69_RS05065	COG0402	S-adenosylhomocysteine deaminase activity
RY69_RS05100	COG2826	transposase and inactivated derivatives, IS30 family
RY69_RS05135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RY69_RS05175	COG3655	Transcriptional regulator
RY69_RS05195	COG1335	isochorismatase
RY69_RS05200	COG3340	Belongs to the peptidase S51 family
RY69_RS05230	COG1131	(ABC) transporter
RY69_RS05235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RY69_RS05240	COG4585	Histidine kinase
RY69_RS05245	COG2197	response regulator
RY69_RS05255	COG0306	phosphate transporter
RY69_RS05260	COG0366	Alpha amylase catalytic
RY69_RS05265	COG0513	Belongs to the DEAD box helicase family
RY69_RS05270	COG2233	PERMEase
RY69_RS05310	COG0730	response to heat
RY69_RS05315	COG0641	radical SAM
RY69_RS05320	COG3119	arylsulfatase activity
RY69_RS05325	COG0477	Major facilitator Superfamily
RY69_RS05340	COG1940	carbohydrate kinase activity
RY69_RS05340	COG1846	Transcriptional regulator
RY69_RS05355	COG0058	SHG alpha-glucan phosphorylase activity
RY69_RS05360	COG2814	Major facilitator Superfamily
RY69_RS05365	COG1309	transcriptional regulator
RY69_RS05410	COG3177	Filamentation induced by cAMP protein fic
RY69_RS05415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RY69_RS05435	COG0012	GTP binding
RY69_RS05440	COG0765	amino acid transport
RY69_RS05445	COG0765	amino acid transport
RY69_RS05450	COG1126	abc transporter atp-binding protein
RY69_RS05455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY69_RS05460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RY69_RS05475	COG2197	response regulator
RY69_RS05480	COG1136	(ABC) transporter
RY69_RS05480	COG0577	efflux transmembrane transporter activity
RY69_RS05485	COG1136	(ABC) transporter
RY69_RS05490	COG2873	o-acetylhomoserine
RY69_RS05520	COG0758	DNA mediated transformation
RY69_RS05525	COG1053	succinate dehydrogenase
RY69_RS05540	COG1611	Belongs to the LOG family
RY69_RS05545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RY69_RS05550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RY69_RS05610	COG1882	Formate acetyltransferase
RY69_RS05625	COG1473	amidohydrolase
RY69_RS05630	COG2011	ABC-type metal ion transport system permease component
RY69_RS05660	COG0406	alpha-ribazole phosphatase activity
RY69_RS05665	COG0799	negative regulation of ribosome biogenesis
RY69_RS05700	COG0857	belongs to the CobB CobQ family
RY69_RS05700	COG0280	phosphate acetyltransferase
RY69_RS05705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RY69_RS05740	COG2823	Periplasmic or secreted lipoprotein
RY69_RS05740	COG1652	LysM domain
RY69_RS05780	COG0519	Catalyzes the synthesis of GMP from XMP
RY69_RS05805	COG1051	belongs to the nudix hydrolase family
RY69_RS05810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RY69_RS05830	COG0494	nUDIX hydrolase
RY69_RS05835	COG0469	pyruvate kinase activity
RY69_RS05855	COG0539	negative regulation of cytoplasmic translation
RY69_RS05870	COG1121	(ABC) transporter
RY69_RS05895	COG0745	RESPONSE REGULATOR receiver
RY69_RS05900	COG2205	protein histidine kinase activity
RY69_RS05905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RY69_RS05940	COG1316	TRANSCRIPTIONal
RY69_RS05965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RY69_RS05975	COG1760	l-serine dehydratase
RY69_RS06010	COG0667	Aldo Keto reductase
RY69_RS06025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RY69_RS06025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RY69_RS06035	COG1472	Belongs to the glycosyl hydrolase 3 family
RY69_RS06040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RY69_RS06085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY69_RS06090	COG0497	DNA recombination
RY69_RS06140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RY69_RS06145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RY69_RS06215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RY69_RS06225	COG1122	ATPase activity
RY69_RS06230	COG4721	ABC-type cobalt transport system, permease component
RY69_RS06235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RY69_RS06285	COG1122	ATPase activity
RY69_RS06290	COG0436	Aminotransferase
RY69_RS06300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RY69_RS06380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RY69_RS06410	COG0626	cystathionine gamma-synthase activity
RY69_RS06430	COG2176	DNA-directed DNA polymerase activity
RY69_RS06440	COG0284	orotidine-5'-phosphate decarboxylase activity
RY69_RS06465	COG1132	(ABC) transporter
RY69_RS06470	COG0390	transport system, permease component
RY69_RS06475	COG2199	diguanylate cyclase activity
RY69_RS06495	COG4974	Belongs to the 'phage' integrase family
RY69_RS06525	COG1175	transmembrane transport
RY69_RS06575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RY69_RS06590	COG1063	alcohol dehydrogenase
RY69_RS06620	COG0583	DNA-binding transcription factor activity
RY69_RS06670	COG0436	Aminotransferase
RY69_RS06685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RY69_RS06740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RY69_RS06760	COG1012	belongs to the aldehyde dehydrogenase family
RY69_RS06780	COG0701	Predicted permease
RY69_RS06825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RY69_RS06830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RY69_RS06835	COG0604	alcohol dehydrogenase
RY69_RS06840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RY69_RS06845	COG0577	efflux transmembrane transporter activity
RY69_RS06845	COG0577	efflux transmembrane transporter activity
RY69_RS06855	COG0577	efflux transmembrane transporter activity
RY69_RS06855	COG1136	(ABC) transporter
RY69_RS06875	COG0366	Alpha amylase catalytic
RY69_RS06880	COG1609	Transcriptional regulator
RY69_RS06915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RY69_RS06920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RY69_RS06945	COG0358	DNA primase activity
RY69_RS06955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RY69_RS06960	COG0531	amino acid
RY69_RS06975	COG0514	ATP-dependent DNA helicase (RecQ)
RY69_RS06980	COG0626	cystathionine gamma-synthase activity
RY69_RS06990	COG4608	Belongs to the ABC transporter superfamily
RY69_RS07000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RY69_RS07005	COG0601	transmembrane transport
RY69_RS07025	COG1653	transport
RY69_RS07035	COG0395	ABC-type sugar transport system, permease component
RY69_RS07040	COG1175	transmembrane transport
RY69_RS07045	COG1609	Transcriptional regulator
RY69_RS07050	COG0564	pseudouridine synthase activity
RY69_RS07060	COG1126	abc transporter atp-binding protein
RY69_RS07085	COG3942	CHAP domain
RY69_RS07085	COG1388	LysM domain
RY69_RS07090	COG2177	Part of the ABC transporter FtsEX involved in
RY69_RS07095	COG2884	Cell division ATP-binding protein ftsE
RY69_RS07100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RY69_RS07125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RY69_RS07145	COG0210	DNA helicase
RY69_RS07160	COG0714	Associated with various cellular activities
RY69_RS07195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RY69_RS07215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RY69_RS07225	COG1349	DNA-binding transcription factor activity
RY69_RS07230	COG0167	dihydroorotate dehydrogenase activity
RY69_RS07235	COG1902	pentaerythritol trinitrate reductase activity
RY69_RS07240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RY69_RS07240	COG4499	WXG100 protein secretion system (Wss), protein YukC
RY69_RS07245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RY69_RS07250	COG0095	Lipoate-protein ligase
RY69_RS07305	COG0489	protein tyrosine kinase activity
RY69_RS07350	COG2801	Transposase and inactivated derivatives
RY69_RS07370	COG2826	transposase and inactivated derivatives, IS30 family
RY69_RS07375	COG0215	cysteine-tRNA ligase activity
RY69_RS07380	COG1215	transferase activity, transferring glycosyl groups
RY69_RS07390	COG0438	transferase activity, transferring glycosyl groups
RY69_RS07405	COG1442	glycosyl transferase family 8
RY69_RS07405	COG1216	Glycosyl transferase, family 2
RY69_RS07435	COG1216	Glycosyl transferase, family 2
RY69_RS07475	COG1215	transferase activity, transferring glycosyl groups
RY69_RS07485	COG1216	Glycosyl transferase, family 2
RY69_RS07485	COG1442	glycosyl transferase family 8
RY69_RS07505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RY69_RS07520	COG2814	Major facilitator Superfamily
RY69_RS07535	COG0656	L-ascorbic acid biosynthetic process
RY69_RS07540	COG3867	Arabinogalactan endo-beta-1,4-galactanase
RY69_RS07555	COG1175	transmembrane transport
RY69_RS07570	COG2814	Major facilitator Superfamily
RY69_RS07575	COG4988	ABC transporter
RY69_RS07580	COG2814	Major facilitator Superfamily
RY69_RS07580	COG0477	Major facilitator Superfamily
RY69_RS07595	COG1609	Transcriptional regulator
RY69_RS07600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RY69_RS07620	COG1116	anion transmembrane transporter activity
RY69_RS07670	COG0667	Aldo Keto reductase
RY69_RS07710	COG0440	acetolactate synthase activity
RY69_RS07720	COG1487	ribonuclease activity
RY69_RS07725	COG0488	(ABC) transporter
RY69_RS07730	COG0519	Catalyzes the synthesis of GMP from XMP
RY69_RS07760	COG1837	Belongs to the UPF0109 family
RY69_RS07800	COG1704	LemA family
RY69_RS07810	COG1136	(ABC) transporter
RY69_RS07860	COG0569	domain protein
RY69_RS07860	COG0475	glutathione-regulated potassium exporter activity
RY69_RS07875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RY69_RS07890	COG3328	transposase activity
RY69_RS07895	COG1373	ATPase (AAA superfamily
RY69_RS07900	COG0395	ABC-type sugar transport system, permease component
RY69_RS07915	COG3119	arylsulfatase activity
RY69_RS07920	COG1609	Transcriptional regulator
RY69_RS07925	COG0641	radical SAM
RY69_RS07930	COG0730	response to heat
RY69_RS07940	COG1027	Aspartate ammonia-lyase
RY69_RS07955	COG3842	ATPase activity
RY69_RS07990	COG0251	oxidation-reduction process
RY69_RS08030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RY69_RS08065	COG0356	it plays a direct role in the translocation of protons across the membrane
RY69_RS08080	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RY69_RS08100	COG3942	CHAP domain
RY69_RS08100	COG1388	LysM domain
RY69_RS08355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RY69_RS08370	COG0745	RESPONSE REGULATOR receiver
RY69_RS08450	COG1131	(ABC) transporter
RY69_RS08470	COG1937	Protein conserved in bacteria
RY69_RS08480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RY69_RS08515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RY69_RS08540	COG3442	glutamine amidotransferase
RY69_RS08545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RY69_RS08550	COG0305	Participates in initiation and elongation during chromosome replication
RY69_RS08560	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RY69_RS08580	COG1309	transcriptional regulator
RY69_RS08585	COG1442	glycosyl transferase family 8
RY69_RS08585	COG1216	Glycosyl transferase, family 2
RY69_RS08615	COG0363	glucosamine-6-phosphate deaminase activity
RY69_RS08620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RY69_RS08650	COG1136	(ABC) transporter
RY69_RS08655	COG0577	efflux transmembrane transporter activity
RY69_RS08670	COG3470	protein probably involved in high-affinity Fe2 transport
RY69_RS08675	COG0672	)-iron permease
RY69_RS08755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RY69_RS08775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RY69_RS08785	COG1754	DNA topoisomerase type I activity
RY69_RS08785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RY69_RS08815	COG2186	Transcriptional regulator
RY69_RS08840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RY69_RS08845	COG4608	Belongs to the ABC transporter superfamily
RY69_RS08850	COG0444	Belongs to the ABC transporter superfamily
RY69_RS08860	COG0747	negative chemotaxis
RY69_RS08870	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RY69_RS08875	COG1940	carbohydrate kinase activity
RY69_RS08895	COG0527	aspartate kinase activity
RY69_RS08930	COG1309	transcriptional regulator
RY69_RS08975	COG0586	Pfam SNARE associated Golgi protein
RY69_RS08980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY69_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
RY69_RS09000	COG0789	Transcriptional regulator
RY69_RS09030	COG1609	Transcriptional regulator
RY69_RS09045	COG1523	belongs to the glycosyl hydrolase 13 family
RY69_RS09050	COG3833	ABC-type maltose transport systems, permease component
RY69_RS09055	COG1175	transmembrane transport
RY69_RS09090	COG1609	Transcriptional regulator
RY69_RS09095	COG0366	Alpha amylase catalytic
RY69_RS09120	COG0477	Major facilitator Superfamily
RY69_RS09125	COG1609	Transcriptional regulator
RY69_RS09165	COG0191	fructose-bisphosphate aldolase activity
RY69_RS09200	COG0343	queuine tRNA-ribosyltransferase activity
RY69_RS09220	COG0494	nUDIX hydrolase
RY69_RS09250	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RY69_RS09255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RY69_RS09270	COG0071	Belongs to the small heat shock protein (HSP20) family
RY69_RS09305	COG0768	penicillin binding
RY69_RS09310	COG0515	serine threonine protein kinase
RY69_RS09350	COG0058	SHG alpha-glucan phosphorylase activity
RY69_RS09370	COG2197	response regulator
RY69_RS09380	COG0180	Tryptophanyl-tRNA synthetase
RY69_RS09395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RY69_RS09405	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RY69_RS09420	COG4251	negative regulation of phosphorylation
RY69_RS09420	COG2203	Gaf domain
RY69_RS09420	COG3706	GGDEF domain
RY69_RS09420	COG5001	Diguanylate cyclase
RY69_RS09485	COG1253	flavin adenine dinucleotide binding
RY69_RS09490	COG0783	Belongs to the Dps family
RY69_RS09500	COG1609	Transcriptional regulator
RY69_RS09545	COG1609	Transcriptional regulator
RY69_RS09565	COG1609	Transcriptional regulator
RY69_RS09585	COG0783	Belongs to the Dps family
RY69_RS09620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RY69_RS09630	COG3250	beta-galactosidase activity
RY69_RS09640	COG1609	Transcriptional regulator
RY69_RS09650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RY69_RS09655	COG0187	DNA topoisomerase II activity
RY69_RS09670	COG0592	DNA-directed DNA polymerase activity
RY69_RS09695	COG1847	R3H domain protein
RY69_RS09705	COG1192	Involved in chromosome partitioning
RY69_RS09710	COG1475	DNA binding
RY69_RS09715	COG0492	ferredoxin-NADP+ reductase activity
RY69_RS09735	COG0617	tRNA 3'-terminal CCA addition
RY69_RS09755	COG3583	domain protein
RY69_RS09790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RY69_RS09800	COG1215	transferase activity, transferring glycosyl groups
RY69_RS09805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RY69_RS09820	COG2188	Transcriptional regulator
RY69_RS09825	COG3842	ATPase activity
RY69_RS09845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RY69_RS09855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY69_RS09855	COG1263	PTS System
RY69_RS09860	COG1263	PTS System
RY69_RS09860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY69_RS09860	COG2190	(PTS) system
RY69_RS09870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RY69_RS09895	COG0730	response to heat
RY69_RS09900	COG0025	NhaP-type Na H and K H
RY69_RS09905	COG0590	tRNA wobble adenosine to inosine editing
RY69_RS09905	COG0037	tRNA processing
RY69_RS09925	COG1175	transmembrane transport
RY69_RS09930	COG0395	ABC-type sugar transport system, permease component
RY69_RS09935	COG0366	Alpha amylase catalytic
RY69_RS09940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RY69_RS09945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RY69_RS10005	COG0588	phosphoglycerate mutase activity
RY69_RS10015	COG1609	Transcriptional regulator
RY69_RS10035	COG1113	amino acid transport
RY69_RS10040	COG1136	(ABC) transporter
RY69_RS10040	COG0577	efflux transmembrane transporter activity
RY69_RS10050	COG1113	amino acid transport
RY69_RS10055	COG1846	Transcriptional regulator
RY69_RS10105	COG3579	cysteine-type endopeptidase activity
RY69_RS10125	COG4166	transmembrane transport
RY69_RS10150	COG1874	Beta-galactosidase
RY69_RS10155	COG1609	Transcriptional regulator
RY69_RS10165	COG1175	transmembrane transport
RY69_RS10170	COG0395	ABC-type sugar transport system, permease component
RY69_RS10190	COG1132	(ABC) transporter
RY69_RS10195	COG1132	(ABC) transporter
RY69_RS10200	COG0084	hydrolase, TatD family'
RY69_RS10220	COG1129	ABC transporter
RY69_RS10225	COG0577	efflux transmembrane transporter activity
RY69_RS10240	COG1316	TRANSCRIPTIONal
RY69_RS10245	COG1373	ATPase (AAA superfamily
RY69_RS10250	COG3757	hydrolase, family 25
RY69_RS10250	COG3409	Peptidoglycan-binding domain 1 protein
RY69_RS10265	COG1088	dTDP-glucose 4,6-dehydratase activity
RY69_RS10285	COG0463	Glycosyl transferase, family 2
RY69_RS10375	COG1216	Glycosyl transferase, family 2
RY69_RS10375	COG1442	glycosyl transferase family 8
RY69_RS10385	COG1070	Carbohydrate kinase
RY69_RS10395	COG1129	ABC transporter
RY69_RS10400	COG1172	Belongs to the binding-protein-dependent transport system permease family
RY69_RS10405	COG1172	Belongs to the binding-protein-dependent transport system permease family
RY69_RS10410	COG1737	Transcriptional regulator
RY69_RS10430	COG3311	Transcriptional regulator
RY69_RS10450	COG0179	Fumarylacetoacetate (FAA) hydrolase
RY69_RS10470	COG0584	glycerophosphoryl diester phosphodiesterase
RY69_RS10500	COG0406	alpha-ribazole phosphatase activity
RY69_RS10500	COG0494	nUDIX hydrolase
RY69_RS10505	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)