locus-tag	class	description
D3H49_RS00030	COG1847	R3H domain protein
D3H49_RS00040	COG1192	Involved in chromosome partitioning
D3H49_RS00070	COG0617	tRNA 3'-terminal CCA addition
D3H49_RS00090	COG3583	domain protein
D3H49_RS00115	COG3279	Response regulator of the LytR AlgR family
D3H49_RS00155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3H49_RS00165	COG1215	transferase activity, transferring glycosyl groups
D3H49_RS00170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H49_RS00180	COG3037	sugar-specific permease SgaT UlaA
D3H49_RS00185	COG2188	Transcriptional regulator
D3H49_RS00190	COG3842	ATPase activity
D3H49_RS00225	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3H49_RS00235	COG1879	ABC-type sugar transport system periplasmic component
D3H49_RS00240	COG1609	Transcriptional regulator
D3H49_RS00275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H49_RS00290	COG1263	PTS System
D3H49_RS00290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H49_RS00290	COG2190	(PTS) system
D3H49_RS00300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3H49_RS00325	COG0730	response to heat
D3H49_RS00330	COG0025	NhaP-type Na H and K H
D3H49_RS00335	COG0590	tRNA wobble adenosine to inosine editing
D3H49_RS00335	COG0037	tRNA processing
D3H49_RS00355	COG1175	transmembrane transport
D3H49_RS00360	COG0395	ABC-type sugar transport system, permease component
D3H49_RS00370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3H49_RS00375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3H49_RS00435	COG0588	phosphoglycerate mutase activity
D3H49_RS00445	COG1609	Transcriptional regulator
D3H49_RS00465	COG1113	amino acid transport
D3H49_RS00470	COG0577	efflux transmembrane transporter activity
D3H49_RS00470	COG1136	(ABC) transporter
D3H49_RS00480	COG1113	amino acid transport
D3H49_RS00490	COG1846	Transcriptional regulator
D3H49_RS00495	COG1132	(ABC) transporter
D3H49_RS00570	COG1132	(ABC) transporter
D3H49_RS00575	COG1132	(ABC) transporter
D3H49_RS00580	COG0084	hydrolase, TatD family'
D3H49_RS00600	COG1129	ABC transporter
D3H49_RS00605	COG0577	efflux transmembrane transporter activity
D3H49_RS00610	COG1316	TRANSCRIPTIONal
D3H49_RS00620	COG1376	ErfK ybiS ycfS ynhG family protein
D3H49_RS00640	COG1088	dTDP-glucose 4,6-dehydratase activity
D3H49_RS00665	COG1216	Glycosyl transferase, family 2
D3H49_RS00665	COG0438	transferase activity, transferring glycosyl groups
D3H49_RS00670	COG1368	sulfuric ester hydrolase activity
D3H49_RS00680	COG1216	Glycosyl transferase, family 2
D3H49_RS00680	COG1442	glycosyl transferase family 8
D3H49_RS00695	COG1070	Carbohydrate kinase
D3H49_RS00705	COG1129	ABC transporter
D3H49_RS00710	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3H49_RS00715	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3H49_RS00740	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3H49_RS00760	COG0584	glycerophosphoryl diester phosphodiesterase
D3H49_RS00805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3H49_RS00840	COG0167	dihydroorotate dehydrogenase activity
D3H49_RS00845	COG1126	abc transporter atp-binding protein
D3H49_RS00860	COG0765	amino acid transport
D3H49_RS00870	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3H49_RS00875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3H49_RS00900	COG1263	PTS System
D3H49_RS00900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H49_RS00900	COG2190	(PTS) system
D3H49_RS00905	COG1263	PTS System
D3H49_RS00905	COG2190	(PTS) system
D3H49_RS00905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H49_RS00910	COG0460	homoserine dehydrogenase
D3H49_RS00915	COG0083	homoserine kinase activity
D3H49_RS00945	COG1609	Transcriptional regulator
D3H49_RS00950	COG4948	Mandelate Racemase Muconate Lactonizing
D3H49_RS00970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H49_RS00980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3H49_RS00985	COG1530	ribonuclease E activity
D3H49_RS01015	COG0436	Aminotransferase
D3H49_RS01025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3H49_RS01030	COG0250	Participates in transcription elongation, termination and antitermination
D3H49_RS01060	COG1268	BioY protein
D3H49_RS01065	COG4770	biotin carboxylase activity
D3H49_RS01070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3H49_RS01150	COG2270	Major facilitator Superfamily
D3H49_RS01155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3H49_RS01155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3H49_RS01170	COG0742	ribosomal rna small subunit methyltransferase
D3H49_RS01210	COG3579	cysteine-type endopeptidase activity
D3H49_RS01225	COG1653	transport
D3H49_RS01230	COG1175	transmembrane transport
D3H49_RS01235	COG0395	ABC-type sugar transport system, permease component
D3H49_RS01250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H49_RS01265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3H49_RS01270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3H49_RS01280	COG0477	Major facilitator Superfamily
D3H49_RS01285	COG5002	protein histidine kinase activity
D3H49_RS01290	COG0745	RESPONSE REGULATOR receiver
D3H49_RS01315	COG2252	PERMEase
D3H49_RS01360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3H49_RS01400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3H49_RS01405	COG0531	amino acid
D3H49_RS01435	COG1609	Transcriptional regulator
D3H49_RS01445	COG1175	transmembrane transport
D3H49_RS01455	COG2723	6-phospho-beta-galactosidase activity
D3H49_RS01465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H49_RS01470	COG1739	Uncharacterized protein family UPF0029
D3H49_RS01525	COG1063	alcohol dehydrogenase
D3H49_RS01535	COG1454	alcohol dehydrogenase
D3H49_RS01535	COG1012	belongs to the aldehyde dehydrogenase family
D3H49_RS01545	COG3527	Alpha-acetolactate decarboxylase
D3H49_RS01595	COG0255	Belongs to the universal ribosomal protein uL29 family
D3H49_RS01700	COG2308	Evidence 4 Homologs of previously reported genes of
D3H49_RS01715	COG1609	Transcriptional regulator
D3H49_RS01770	COG0328	RNA-DNA hybrid ribonuclease activity
D3H49_RS01775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H49_RS01805	COG1597	lipid kinase activity
D3H49_RS01805	COG1803	Methylglyoxal synthase
D3H49_RS01830	COG0395	ABC-type sugar transport system, permease component
D3H49_RS01850	COG2197	response regulator
D3H49_RS01885	COG2814	Major facilitator Superfamily
D3H49_RS01900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3H49_RS01905	COG1575	Belongs to the MenA family. Type 1 subfamily
D3H49_RS01920	COG5002	protein histidine kinase activity
D3H49_RS01930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D3H49_RS01935	COG3942	CHAP domain
D3H49_RS01935	COG1705	Flagellar rod assembly protein muramidase FlgJ
D3H49_RS01945	COG3103	Sh3 type 3 domain protein
D3H49_RS01945	COG1388	LysM domain
D3H49_RS01945	COG0791	NLP P60 protein
D3H49_RS01950	COG0589	response to stress
D3H49_RS01970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3H49_RS01990	COG0577	efflux transmembrane transporter activity
D3H49_RS02030	COG1609	Transcriptional regulator
D3H49_RS02040	COG3250	beta-galactosidase activity
D3H49_RS02075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3H49_RS02080	COG1454	alcohol dehydrogenase
D3H49_RS02085	COG0463	Glycosyl transferase, family 2
D3H49_RS02095	COG1215	transferase activity, transferring glycosyl groups
D3H49_RS02125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3H49_RS02140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3H49_RS02170	COG1940	carbohydrate kinase activity
D3H49_RS02190	COG0242	peptide deformylase activity
D3H49_RS02200	COG2814	Major facilitator Superfamily
D3H49_RS02265	COG0009	L-threonylcarbamoyladenylate synthase
D3H49_RS02270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3H49_RS02285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3H49_RS02355	COG0436	Aminotransferase
D3H49_RS02360	COG0248	Ppx GppA phosphatase
D3H49_RS02380	COG1970	mechanosensitive ion channel activity
D3H49_RS02385	COG1022	Amp-dependent synthetase and ligase
D3H49_RS02390	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3H49_RS02395	COG1722	exodeoxyribonuclease VII activity
D3H49_RS02400	COG1570	exodeoxyribonuclease VII activity
D3H49_RS02405	COG1328	CTP reductase activity
D3H49_RS02405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3H49_RS02410	COG0602	queuosine metabolic process
D3H49_RS02425	COG1309	transcriptional regulator
D3H49_RS02460	COG2182	Extracellular solute-binding protein
D3H49_RS02470	COG0154	amidase activity
D3H49_RS02480	COG1609	Transcriptional regulator
D3H49_RS02495	COG2211	Major facilitator Superfamily
D3H49_RS02500	COG1285	pathogenesis
D3H49_RS02560	COG1132	(ABC) transporter
D3H49_RS02565	COG1132	(ABC) transporter
D3H49_RS02590	COG1122	ATPase activity
D3H49_RS02595	COG0135	phosphoribosylanthranilate isomerase activity
D3H49_RS02600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H49_RS02610	COG0546	phosphoglycolate phosphatase activity
D3H49_RS02615	COG1979	alcohol dehydrogenase
D3H49_RS02620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H49_RS02645	COG1129	ABC transporter
D3H49_RS02650	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3H49_RS02655	COG1879	ABC-type sugar transport system periplasmic component
D3H49_RS02660	COG1869	D-ribose catabolic process
D3H49_RS02665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H49_RS02675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3H49_RS02680	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3H49_RS02690	COG3842	ATPase activity
D3H49_RS02705	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D3H49_RS02710	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D3H49_RS02800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3H49_RS02805	COG0560	Phosphoserine phosphatase
D3H49_RS02810	COG0586	Pfam SNARE associated Golgi protein
D3H49_RS02820	COG1011	Hydrolase
D3H49_RS02835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H49_RS02835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3H49_RS02835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3H49_RS02840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3H49_RS02850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3H49_RS02855	COG4122	O-methyltransferase activity
D3H49_RS02885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3H49_RS02930	COG0714	Associated with various cellular activities
D3H49_RS02945	COG1278	Cold shock
D3H49_RS02965	COG0745	RESPONSE REGULATOR receiver
D3H49_RS02970	COG2205	protein histidine kinase activity
D3H49_RS02975	COG1278	Cold shock
D3H49_RS02985	COG0589	response to stress
D3H49_RS02990	COG0542	response to heat
D3H49_RS03000	COG0477	Major facilitator Superfamily
D3H49_RS03015	COG1196	nuclear chromosome segregation
D3H49_RS03035	COG1126	abc transporter atp-binding protein
D3H49_RS03040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H49_RS03045	COG0765	amino acid transport
D3H49_RS03050	COG0765	amino acid transport
D3H49_RS03060	COG1279	arginine transmembrane transporter activity
D3H49_RS03065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H49_RS03070	COG2326	polyphosphate kinase activity
D3H49_RS03075	COG4581	dead DEAH box helicase
D3H49_RS03090	COG2814	Major facilitator Superfamily
D3H49_RS03095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H49_RS03165	COG2197	response regulator
D3H49_RS03175	COG2271	Major facilitator Superfamily
D3H49_RS03185	COG0351	phosphomethylpyrimidine kinase
D3H49_RS03185	COG0352	thiamine-phosphate diphosphorylase activity
D3H49_RS03190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3H49_RS03215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3H49_RS03250	COG0587	DNA-directed DNA polymerase activity
D3H49_RS03265	COG4716	Myosin-crossreactive antigen
D3H49_RS03315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H49_RS03325	COG0656	L-ascorbic acid biosynthetic process
D3H49_RS03375	COG2814	Major facilitator Superfamily
D3H49_RS03380	COG1643	Atp-dependent helicase
D3H49_RS03390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3H49_RS03420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H49_RS03445	COG0768	penicillin binding
D3H49_RS03455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D3H49_RS03500	COG0738	Major facilitator superfamily
D3H49_RS03515	COG1940	carbohydrate kinase activity
D3H49_RS03520	COG1940	carbohydrate kinase activity
D3H49_RS03540	COG0006	proline dipeptidase activity
D3H49_RS03545	COG0285	dihydrofolate synthase activity
D3H49_RS03550	COG1196	nuclear chromosome segregation
D3H49_RS03570	COG1595	DNA-templated transcription, initiation
D3H49_RS03580	COG2017	converts alpha-aldose to the beta-anomer
D3H49_RS03585	COG2017	converts alpha-aldose to the beta-anomer
D3H49_RS03595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3H49_RS03620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3H49_RS03635	COG3835	regulator
D3H49_RS03640	COG2610	gluconate transmembrane transporter activity
D3H49_RS03645	COG1929	Belongs to the glycerate kinase type-1 family
D3H49_RS03660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3H49_RS03665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3H49_RS03675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D3H49_RS03695	COG0477	Major facilitator Superfamily
D3H49_RS03705	COG4591	ABC-type transport system involved in lipoprotein release permease component
D3H49_RS03705	COG1136	(ABC) transporter
D3H49_RS03730	COG0287	Prephenate dehydrogenase
D3H49_RS03745	COG0577	efflux transmembrane transporter activity
D3H49_RS03745	COG1136	(ABC) transporter
D3H49_RS03755	COG4166	transmembrane transport
D3H49_RS03760	COG0601	transmembrane transport
D3H49_RS03765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H49_RS03770	COG4172	Belongs to the ABC transporter superfamily
D3H49_RS03775	COG0708	Exodeoxyribonuclease III
D3H49_RS03800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3H49_RS03830	COG2357	RelA SpoT domain protein
D3H49_RS03860	COG1058	Belongs to the CinA family
D3H49_RS03860	COG1546	Belongs to the CinA family
D3H49_RS03865	COG1396	sequence-specific DNA binding
D3H49_RS03890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3H49_RS03900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3H49_RS03920	COG0142	geranyltranstransferase activity
D3H49_RS03930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3H49_RS03935	COG0187	DNA topoisomerase II activity
D3H49_RS03945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H49_RS03950	COG1201	RNA secondary structure unwinding
D3H49_RS03960	COG2207	Transcriptional regulator
D3H49_RS03975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3H49_RS04000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3H49_RS04060	COG1653	transport
D3H49_RS04065	COG1175	transmembrane transport
D3H49_RS04070	COG0395	ABC-type sugar transport system, permease component
D3H49_RS04125	COG0406	alpha-ribazole phosphatase activity
D3H49_RS04130	COG0598	Magnesium transport protein CorA
D3H49_RS04135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H49_RS04160	COG0802	atpase or kinase
D3H49_RS04170	COG0456	acetyltransferase
D3H49_RS04220	COG1192	Involved in chromosome partitioning
D3H49_RS04350	COG3550	peptidyl-serine autophosphorylation
D3H49_RS04365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3H49_RS04365	COG0551	DNA topoisomerase type I activity
D3H49_RS04385	COG3942	CHAP domain
D3H49_RS04470	COG0516	GMP reductase activity
D3H49_RS04510	COG0575	Belongs to the CDS family
D3H49_RS04520	COG0693	protein deglycase activity
D3H49_RS04555	COG3189	MarR family transcriptional regulator
D3H49_RS04565	COG0833	amino acid
D3H49_RS04625	COG1131	(ABC) transporter
D3H49_RS04680	COG0745	RESPONSE REGULATOR receiver
D3H49_RS04730	COG0833	amino acid
D3H49_RS04740	COG2135	peptidase activity
D3H49_RS04745	COG0133	tryptophan synthase activity
D3H49_RS04760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3H49_RS04795	COG1716	ATPase activity
D3H49_RS04845	COG0561	phosphatase activity
D3H49_RS04860	COG1187	pseudouridine synthase activity
D3H49_RS04865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3H49_RS04890	COG0045	succinate-CoA ligase (ADP-forming) activity
D3H49_RS05070	COG1475	DNA binding
D3H49_RS05285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3H49_RS05300	COG0436	Aminotransferase
D3H49_RS05315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3H49_RS05340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3H49_RS05370	COG4221	oxidoreductase activity
D3H49_RS05375	COG0488	(ABC) transporter
D3H49_RS05390	COG0583	DNA-binding transcription factor activity
D3H49_RS05410	COG0167	dihydroorotate dehydrogenase activity
D3H49_RS05415	COG0543	2 iron, 2 sulfur cluster binding
D3H49_RS05420	COG0284	orotidine-5'-phosphate decarboxylase activity
D3H49_RS05425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3H49_RS05445	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D3H49_RS05450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D3H49_RS05460	COG0588	phosphoglycerate mutase activity
D3H49_RS05480	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D3H49_RS05490	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3H49_RS05515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3H49_RS05575	COG0297	glycogen (starch) synthase activity
D3H49_RS05590	COG4166	transmembrane transport
D3H49_RS05605	COG2771	luxR family
D3H49_RS05620	COG0067	glutamate synthase
D3H49_RS05620	COG0069	glutamate synthase activity
D3H49_RS05620	COG0070	glutamate synthase
D3H49_RS05650	COG2860	membrane
D3H49_RS05660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3H49_RS05675	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3H49_RS05680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3H49_RS05685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3H49_RS05690	COG1022	Amp-dependent synthetase and ligase
D3H49_RS05715	COG0537	adenosine 5'-monophosphoramidase activity
D3H49_RS05720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3H49_RS05740	COG2151	metal-sulfur cluster biosynthetic enzyme
D3H49_RS05750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3H49_RS05755	COG0396	ATPase activity
D3H49_RS05760	COG0719	Fe-S assembly protein
D3H49_RS05780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3H49_RS05860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3H49_RS05900	COG3655	Transcriptional regulator
D3H49_RS05920	COG1335	isochorismatase
D3H49_RS05925	COG3340	Belongs to the peptidase S51 family
D3H49_RS05955	COG1131	(ABC) transporter
D3H49_RS05970	COG2197	response regulator
D3H49_RS05980	COG0306	phosphate transporter
D3H49_RS05985	COG0366	Alpha amylase catalytic
D3H49_RS05990	COG0513	Belongs to the DEAD box helicase family
D3H49_RS05995	COG2233	PERMEase
D3H49_RS06035	COG0730	response to heat
D3H49_RS06040	COG0641	radical SAM
D3H49_RS06045	COG3119	arylsulfatase activity
D3H49_RS06065	COG1846	Transcriptional regulator
D3H49_RS06065	COG1940	carbohydrate kinase activity
D3H49_RS06090	COG2814	Major facilitator Superfamily
D3H49_RS06100	COG0012	GTP binding
D3H49_RS06105	COG0765	amino acid transport
D3H49_RS06110	COG0765	amino acid transport
D3H49_RS06115	COG1126	abc transporter atp-binding protein
D3H49_RS06125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3H49_RS06140	COG2197	response regulator
D3H49_RS06145	COG0577	efflux transmembrane transporter activity
D3H49_RS06145	COG1136	(ABC) transporter
D3H49_RS06150	COG1136	(ABC) transporter
D3H49_RS06175	COG0606	chelatase, subunit chli
D3H49_RS06180	COG0758	DNA mediated transformation
D3H49_RS06185	COG1053	succinate dehydrogenase
D3H49_RS06200	COG1611	Belongs to the LOG family
D3H49_RS06205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H49_RS06210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D3H49_RS06270	COG1882	Formate acetyltransferase
D3H49_RS06290	COG2011	ABC-type metal ion transport system permease component
D3H49_RS06320	COG0406	alpha-ribazole phosphatase activity
D3H49_RS06325	COG0799	negative regulation of ribosome biogenesis
D3H49_RS06360	COG0857	belongs to the CobB CobQ family
D3H49_RS06360	COG0280	phosphate acetyltransferase
D3H49_RS06365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3H49_RS06390	COG0519	Catalyzes the synthesis of GMP from XMP
D3H49_RS06415	COG1051	belongs to the nudix hydrolase family
D3H49_RS06420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D3H49_RS06440	COG0494	nUDIX hydrolase
D3H49_RS06445	COG0469	pyruvate kinase activity
D3H49_RS06465	COG0539	negative regulation of cytoplasmic translation
D3H49_RS06480	COG1121	(ABC) transporter
D3H49_RS06485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3H49_RS06505	COG0745	RESPONSE REGULATOR receiver
D3H49_RS06510	COG2205	protein histidine kinase activity
D3H49_RS06515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3H49_RS06545	COG1316	TRANSCRIPTIONal
D3H49_RS06580	COG1760	l-serine dehydratase
D3H49_RS06615	COG0667	Aldo Keto reductase
D3H49_RS06645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3H49_RS06710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H49_RS06715	COG0497	DNA recombination
D3H49_RS06770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H49_RS06775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3H49_RS06800	COG4115	mRNA cleavage
D3H49_RS06825	COG1116	anion transmembrane transporter activity
D3H49_RS06880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H49_RS06890	COG1122	ATPase activity
D3H49_RS06895	COG4721	ABC-type cobalt transport system, permease component
D3H49_RS06900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3H49_RS06910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H49_RS06945	COG1122	ATPase activity
D3H49_RS06960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3H49_RS07040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3H49_RS07075	COG0626	cystathionine gamma-synthase activity
D3H49_RS07095	COG2176	DNA-directed DNA polymerase activity
D3H49_RS07105	COG0284	orotidine-5'-phosphate decarboxylase activity
D3H49_RS07130	COG0577	efflux transmembrane transporter activity
D3H49_RS07130	COG1136	(ABC) transporter
D3H49_RS07135	COG0390	transport system, permease component
D3H49_RS07140	COG2199	diguanylate cyclase activity
D3H49_RS07165	COG0110	maltose O-acetyltransferase activity
D3H49_RS07170	COG0110	maltose O-acetyltransferase activity
D3H49_RS07210	COG1063	alcohol dehydrogenase
D3H49_RS07240	COG0583	DNA-binding transcription factor activity
D3H49_RS07270	COG0385	Bile acid
D3H49_RS07290	COG0436	Aminotransferase
D3H49_RS07365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3H49_RS07385	COG1012	belongs to the aldehyde dehydrogenase family
D3H49_RS07415	COG0701	Predicted permease
D3H49_RS07460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3H49_RS07465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3H49_RS07470	COG0604	alcohol dehydrogenase
D3H49_RS07475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3H49_RS07480	COG0577	efflux transmembrane transporter activity
D3H49_RS07480	COG1136	(ABC) transporter
D3H49_RS07490	COG0577	efflux transmembrane transporter activity
D3H49_RS07490	COG1136	(ABC) transporter
D3H49_RS07525	COG1609	Transcriptional regulator
D3H49_RS07560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3H49_RS07565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H49_RS07590	COG0358	DNA primase activity
D3H49_RS07600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3H49_RS07605	COG0531	amino acid
D3H49_RS07620	COG0514	ATP-dependent DNA helicase (RecQ)
D3H49_RS07625	COG0626	cystathionine gamma-synthase activity
D3H49_RS07635	COG4608	Belongs to the ABC transporter superfamily
D3H49_RS07645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H49_RS07650	COG0601	transmembrane transport
D3H49_RS07670	COG1653	transport
D3H49_RS07680	COG0395	ABC-type sugar transport system, permease component
D3H49_RS07690	COG1609	Transcriptional regulator
D3H49_RS07695	COG0564	pseudouridine synthase activity
D3H49_RS07705	COG1126	abc transporter atp-binding protein
D3H49_RS07730	COG3942	CHAP domain
D3H49_RS07730	COG1388	LysM domain
D3H49_RS07735	COG2177	Part of the ABC transporter FtsEX involved in
D3H49_RS07740	COG2884	Cell division ATP-binding protein ftsE
D3H49_RS07745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D3H49_RS07770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D3H49_RS07790	COG0210	DNA helicase
D3H49_RS07805	COG0714	Associated with various cellular activities
D3H49_RS07840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3H49_RS07855	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D3H49_RS07865	COG1349	DNA-binding transcription factor activity
D3H49_RS07870	COG0167	dihydroorotate dehydrogenase activity
D3H49_RS07875	COG1902	pentaerythritol trinitrate reductase activity
D3H49_RS07880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3H49_RS07880	COG4499	WXG100 protein secretion system (Wss), protein YukC
D3H49_RS07885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H49_RS07890	COG0095	Lipoate-protein ligase
D3H49_RS07950	COG0489	protein tyrosine kinase activity
D3H49_RS07985	COG1484	DNA-dependent DNA replication
D3H49_RS08010	COG1216	Glycosyl transferase, family 2
D3H49_RS08020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3H49_RS08025	COG1216	Glycosyl transferase, family 2
D3H49_RS08025	COG1442	glycosyl transferase family 8
D3H49_RS08040	COG0438	transferase activity, transferring glycosyl groups
D3H49_RS08050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3H49_RS08065	COG2814	Major facilitator Superfamily
D3H49_RS08085	COG0656	L-ascorbic acid biosynthetic process
D3H49_RS08090	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D3H49_RS08105	COG0395	ABC-type sugar transport system, permease component
D3H49_RS08115	COG1653	transport
D3H49_RS08120	COG2814	Major facilitator Superfamily
D3H49_RS08125	COG4988	ABC transporter
D3H49_RS08140	COG0477	Major facilitator Superfamily
D3H49_RS08140	COG2814	Major facilitator Superfamily
D3H49_RS08155	COG1609	Transcriptional regulator
D3H49_RS08160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D3H49_RS08180	COG1116	anion transmembrane transporter activity
D3H49_RS08230	COG0667	Aldo Keto reductase
D3H49_RS08270	COG0440	acetolactate synthase activity
D3H49_RS08280	COG1487	ribonuclease activity
D3H49_RS08285	COG0488	(ABC) transporter
D3H49_RS08300	COG0505	Belongs to the CarA family
D3H49_RS08330	COG1837	Belongs to the UPF0109 family
D3H49_RS08365	COG1704	LemA family
D3H49_RS08375	COG1136	(ABC) transporter
D3H49_RS08425	COG0569	domain protein
D3H49_RS08425	COG0475	glutathione-regulated potassium exporter activity
D3H49_RS08440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3H49_RS08465	COG1373	ATPase (AAA superfamily
D3H49_RS08470	COG0395	ABC-type sugar transport system, permease component
D3H49_RS08485	COG3119	arylsulfatase activity
D3H49_RS08490	COG1609	Transcriptional regulator
D3H49_RS08495	COG0641	radical SAM
D3H49_RS08500	COG0730	response to heat
D3H49_RS08510	COG1027	Aspartate ammonia-lyase
D3H49_RS08525	COG3842	ATPase activity
D3H49_RS08560	COG0251	oxidation-reduction process
D3H49_RS08600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D3H49_RS08635	COG0356	it plays a direct role in the translocation of protons across the membrane
D3H49_RS08660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3H49_RS08675	COG0745	RESPONSE REGULATOR receiver
D3H49_RS08715	COG0395	ABC-type sugar transport system, permease component
D3H49_RS08790	COG1131	(ABC) transporter
D3H49_RS08810	COG1937	Protein conserved in bacteria
D3H49_RS08820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3H49_RS08855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D3H49_RS08880	COG3442	glutamine amidotransferase
D3H49_RS08885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D3H49_RS08890	COG0305	Participates in initiation and elongation during chromosome replication
D3H49_RS08900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D3H49_RS08920	COG1309	transcriptional regulator
D3H49_RS08925	COG1216	Glycosyl transferase, family 2
D3H49_RS08925	COG1442	glycosyl transferase family 8
D3H49_RS08955	COG0363	glucosamine-6-phosphate deaminase activity
D3H49_RS08960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3H49_RS08990	COG1136	(ABC) transporter
D3H49_RS08995	COG0577	efflux transmembrane transporter activity
D3H49_RS09010	COG3470	protein probably involved in high-affinity Fe2 transport
D3H49_RS09015	COG0672	)-iron permease
D3H49_RS09085	COG2910	NAD(P)H-binding
D3H49_RS09090	COG1733	regulation of RNA biosynthetic process
D3H49_RS09095	COG3619	membrane
D3H49_RS09175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3H49_RS09190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D3H49_RS09200	COG1754	DNA topoisomerase type I activity
D3H49_RS09200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3H49_RS09230	COG2186	Transcriptional regulator
D3H49_RS09255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H49_RS09260	COG4608	Belongs to the ABC transporter superfamily
D3H49_RS09265	COG0444	Belongs to the ABC transporter superfamily
D3H49_RS09285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D3H49_RS09290	COG1940	carbohydrate kinase activity
D3H49_RS09310	COG0527	aspartate kinase activity
D3H49_RS09355	COG1309	transcriptional regulator
D3H49_RS09400	COG0586	Pfam SNARE associated Golgi protein
D3H49_RS09405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H49_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
D3H49_RS09425	COG0789	Transcriptional regulator
D3H49_RS09445	COG1523	belongs to the glycosyl hydrolase 13 family
D3H49_RS09460	COG3833	ABC-type maltose transport systems, permease component
D3H49_RS09465	COG1175	transmembrane transport
D3H49_RS09505	COG0366	Alpha amylase catalytic
D3H49_RS09520	COG0477	Major facilitator Superfamily
D3H49_RS09525	COG1609	Transcriptional regulator
D3H49_RS09565	COG0191	fructose-bisphosphate aldolase activity
D3H49_RS09570	COG0697	spore germination
D3H49_RS09600	COG0343	queuine tRNA-ribosyltransferase activity
D3H49_RS09620	COG0494	nUDIX hydrolase
D3H49_RS09655	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D3H49_RS09660	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D3H49_RS09670	COG0697	spore germination
D3H49_RS09675	COG0071	Belongs to the small heat shock protein (HSP20) family
D3H49_RS09710	COG0768	penicillin binding
D3H49_RS09715	COG0515	serine threonine protein kinase
D3H49_RS09755	COG0058	SHG alpha-glucan phosphorylase activity
D3H49_RS09770	COG0180	Tryptophanyl-tRNA synthetase
D3H49_RS09785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H49_RS09795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3H49_RS09810	COG2203	Gaf domain
D3H49_RS09810	COG3706	GGDEF domain
D3H49_RS09810	COG4251	negative regulation of phosphorylation
D3H49_RS09810	COG5001	Diguanylate cyclase
D3H49_RS09860	COG0450	alkyl hydroperoxide reductase
D3H49_RS09875	COG1253	flavin adenine dinucleotide binding
D3H49_RS09880	COG0783	Belongs to the Dps family
D3H49_RS09915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3H49_RS09925	COG3250	beta-galactosidase activity
D3H49_RS09935	COG1609	Transcriptional regulator
D3H49_RS09945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3H49_RS09950	COG0187	DNA topoisomerase II activity
D3H49_RS09965	COG0592	DNA-directed DNA polymerase activity