locus-tag	class	description
B2258_RS00010	COG0592	DNA-directed DNA polymerase activity
B2258_RS00025	COG0187	DNA topoisomerase II activity
B2258_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B2258_RS00040	COG1609	Transcriptional regulator
B2258_RS00050	COG3250	beta-galactosidase activity
B2258_RS00060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B2258_RS00090	COG0783	Belongs to the Dps family
B2258_RS00095	COG1253	flavin adenine dinucleotide binding
B2258_RS00160	COG2203	Gaf domain
B2258_RS00160	COG3706	GGDEF domain
B2258_RS00160	COG4251	negative regulation of phosphorylation
B2258_RS00160	COG5001	Diguanylate cyclase
B2258_RS00180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B2258_RS00190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B2258_RS00205	COG0180	Tryptophanyl-tRNA synthetase
B2258_RS00220	COG0058	SHG alpha-glucan phosphorylase activity
B2258_RS00260	COG0515	serine threonine protein kinase
B2258_RS00265	COG0768	penicillin binding
B2258_RS00300	COG0071	Belongs to the small heat shock protein (HSP20) family
B2258_RS00305	COG0697	spore germination
B2258_RS00315	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B2258_RS00320	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B2258_RS00340	COG1216	Glycosyl transferase, family 2
B2258_RS00350	COG0494	nUDIX hydrolase
B2258_RS00370	COG0343	queuine tRNA-ribosyltransferase activity
B2258_RS00400	COG0697	spore germination
B2258_RS00405	COG0191	fructose-bisphosphate aldolase activity
B2258_RS00445	COG1609	Transcriptional regulator
B2258_RS00450	COG0477	Major facilitator Superfamily
B2258_RS00465	COG0366	Alpha amylase catalytic
B2258_RS00470	COG1609	Transcriptional regulator
B2258_RS00505	COG1175	transmembrane transport
B2258_RS00510	COG3833	ABC-type maltose transport systems, permease component
B2258_RS00525	COG1523	belongs to the glycosyl hydrolase 13 family
B2258_RS00545	COG0789	Transcriptional regulator
B2258_RS00560	COG1028	Short-chain dehydrogenase reductase Sdr
B2258_RS00565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B2258_RS00570	COG0586	Pfam SNARE associated Golgi protein
B2258_RS00615	COG1309	transcriptional regulator
B2258_RS00660	COG0527	aspartate kinase activity
B2258_RS00680	COG1940	carbohydrate kinase activity
B2258_RS00685	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
B2258_RS00695	COG0747	negative chemotaxis
B2258_RS00705	COG0444	Belongs to the ABC transporter superfamily
B2258_RS00710	COG4608	Belongs to the ABC transporter superfamily
B2258_RS00715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2258_RS00740	COG2186	Transcriptional regulator
B2258_RS00765	COG1754	DNA topoisomerase type I activity
B2258_RS00765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B2258_RS00775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B2258_RS00790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B2258_RS00875	COG3619	membrane
B2258_RS00880	COG1733	regulation of RNA biosynthetic process
B2258_RS00885	COG2910	NAD(P)H-binding
B2258_RS00895	COG0477	Major facilitator Superfamily
B2258_RS00900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B2258_RS00905	COG3321	synthase
B2258_RS00905	COG1028	Short-chain dehydrogenase reductase Sdr
B2258_RS00905	COG0604	alcohol dehydrogenase
B2258_RS00915	COG2977	Belongs to the P-Pant transferase superfamily
B2258_RS00940	COG2801	Transposase and inactivated derivatives
B2258_RS00975	COG0672	)-iron permease
B2258_RS00980	COG3470	protein probably involved in high-affinity Fe2 transport
B2258_RS00995	COG0577	efflux transmembrane transporter activity
B2258_RS01000	COG1136	(ABC) transporter
B2258_RS01030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B2258_RS01035	COG0363	glucosamine-6-phosphate deaminase activity
B2258_RS01065	COG1216	Glycosyl transferase, family 2
B2258_RS01065	COG1442	glycosyl transferase family 8
B2258_RS01070	COG1309	transcriptional regulator
B2258_RS01090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B2258_RS01100	COG0305	Participates in initiation and elongation during chromosome replication
B2258_RS01105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B2258_RS01110	COG3442	glutamine amidotransferase
B2258_RS01135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B2258_RS01185	COG1131	(ABC) transporter
B2258_RS01235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B2258_RS01245	COG1937	Protein conserved in bacteria
B2258_RS01265	COG1131	(ABC) transporter
B2258_RS01330	COG2182	Extracellular solute-binding protein
B2258_RS01340	COG0395	ABC-type sugar transport system, permease component
B2258_RS01380	COG0745	RESPONSE REGULATOR receiver
B2258_RS01395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B2258_RS01420	COG0356	it plays a direct role in the translocation of protons across the membrane
B2258_RS01455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B2258_RS01495	COG0251	oxidation-reduction process
B2258_RS01530	COG3842	ATPase activity
B2258_RS01545	COG1027	Aspartate ammonia-lyase
B2258_RS01555	COG0730	response to heat
B2258_RS01560	COG0641	radical SAM
B2258_RS01565	COG1609	Transcriptional regulator
B2258_RS01570	COG3119	arylsulfatase activity
B2258_RS01585	COG0395	ABC-type sugar transport system, permease component
B2258_RS01590	COG1373	ATPase (AAA superfamily
B2258_RS01595	COG3328	transposase activity
B2258_RS01610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2258_RS01625	COG0569	domain protein
B2258_RS01625	COG0475	glutathione-regulated potassium exporter activity
B2258_RS01685	COG1136	(ABC) transporter
B2258_RS01695	COG1704	LemA family
B2258_RS01730	COG1837	Belongs to the UPF0109 family
B2258_RS01760	COG0505	Belongs to the CarA family
B2258_RS01770	COG0488	(ABC) transporter
B2258_RS01775	COG1487	ribonuclease activity
B2258_RS01785	COG0440	acetolactate synthase activity
B2258_RS01825	COG0667	Aldo Keto reductase
B2258_RS01875	COG1116	anion transmembrane transporter activity
B2258_RS01895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B2258_RS01900	COG1609	Transcriptional regulator
B2258_RS01915	COG0477	Major facilitator Superfamily
B2258_RS01915	COG2814	Major facilitator Superfamily
B2258_RS01925	COG4988	ABC transporter
B2258_RS01940	COG1653	transport
B2258_RS01945	COG1175	transmembrane transport
B2258_RS01950	COG0395	ABC-type sugar transport system, permease component
B2258_RS01965	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B2258_RS01970	COG0656	L-ascorbic acid biosynthetic process
B2258_RS01985	COG2814	Major facilitator Superfamily
B2258_RS02000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B2258_RS02010	COG2801	Transposase and inactivated derivatives
B2258_RS02030	COG1216	Glycosyl transferase, family 2
B2258_RS02050	COG3328	transposase activity
B2258_RS02070	COG2801	Transposase and inactivated derivatives
B2258_RS02125	COG0489	protein tyrosine kinase activity
B2258_RS02180	COG0095	Lipoate-protein ligase
B2258_RS02185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B2258_RS02190	COG4499	WXG100 protein secretion system (Wss), protein YukC
B2258_RS02190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B2258_RS02195	COG1902	pentaerythritol trinitrate reductase activity
B2258_RS02200	COG0167	dihydroorotate dehydrogenase activity
B2258_RS02205	COG1349	DNA-binding transcription factor activity
B2258_RS02215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B2258_RS02235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B2258_RS02270	COG0714	Associated with various cellular activities
B2258_RS02285	COG0210	DNA helicase
B2258_RS02305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B2258_RS02330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B2258_RS02335	COG2884	Cell division ATP-binding protein ftsE
B2258_RS02340	COG2177	Part of the ABC transporter FtsEX involved in
B2258_RS02345	COG3942	CHAP domain
B2258_RS02345	COG1388	LysM domain
B2258_RS02370	COG1126	abc transporter atp-binding protein
B2258_RS02380	COG0564	pseudouridine synthase activity
B2258_RS02385	COG1609	Transcriptional regulator
B2258_RS02390	COG1175	transmembrane transport
B2258_RS02395	COG0395	ABC-type sugar transport system, permease component
B2258_RS02405	COG1653	transport
B2258_RS02425	COG0601	transmembrane transport
B2258_RS02430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2258_RS02440	COG4608	Belongs to the ABC transporter superfamily
B2258_RS02450	COG0626	cystathionine gamma-synthase activity
B2258_RS02455	COG0514	ATP-dependent DNA helicase (RecQ)
B2258_RS02470	COG0531	amino acid
B2258_RS02475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B2258_RS02485	COG0358	DNA primase activity
B2258_RS02510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2258_RS02515	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B2258_RS02550	COG1609	Transcriptional regulator
B2258_RS02555	COG0366	Alpha amylase catalytic
B2258_RS02575	COG0577	efflux transmembrane transporter activity
B2258_RS02575	COG1136	(ABC) transporter
B2258_RS02585	COG1136	(ABC) transporter
B2258_RS02585	COG0577	efflux transmembrane transporter activity
B2258_RS02590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B2258_RS02595	COG0604	alcohol dehydrogenase
B2258_RS02600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B2258_RS02605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B2258_RS02650	COG0701	Predicted permease
B2258_RS02665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B2258_RS02690	COG1012	belongs to the aldehyde dehydrogenase family
B2258_RS02710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B2258_RS02770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B2258_RS02785	COG0436	Aminotransferase
B2258_RS02835	COG0583	DNA-binding transcription factor activity
B2258_RS02865	COG1063	alcohol dehydrogenase
B2258_RS02895	COG1175	transmembrane transport
B2258_RS02915	COG0583	DNA-binding transcription factor activity
B2258_RS02920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B2258_RS02940	COG0110	maltose O-acetyltransferase activity
B2258_RS02945	COG0110	maltose O-acetyltransferase activity
B2258_RS02970	COG2199	diguanylate cyclase activity
B2258_RS02975	COG0390	transport system, permease component
B2258_RS02980	COG0577	efflux transmembrane transporter activity
B2258_RS02980	COG1136	(ABC) transporter
B2258_RS03005	COG0284	orotidine-5'-phosphate decarboxylase activity
B2258_RS03015	COG2176	DNA-directed DNA polymerase activity
B2258_RS03035	COG0626	cystathionine gamma-synthase activity
B2258_RS03070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B2258_RS03150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2258_RS03165	COG1122	ATPase activity
B2258_RS03205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2258_RS03215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2258_RS03220	COG4721	ABC-type cobalt transport system, permease component
B2258_RS03225	COG1122	ATPase activity
B2258_RS03235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B2258_RS03295	COG4115	mRNA cleavage
B2258_RS03320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B2258_RS03325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B2258_RS03385	COG0497	DNA recombination
B2258_RS03440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B2258_RS03445	COG1472	Belongs to the glycosyl hydrolase 3 family
B2258_RS03470	COG0667	Aldo Keto reductase
B2258_RS03505	COG1760	l-serine dehydratase
B2258_RS03515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B2258_RS03540	COG1316	TRANSCRIPTIONal
B2258_RS03580	COG2205	protein histidine kinase activity
B2258_RS03585	COG0745	RESPONSE REGULATOR receiver
B2258_RS03605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B2258_RS03610	COG1121	(ABC) transporter
B2258_RS03625	COG0539	negative regulation of cytoplasmic translation
B2258_RS03645	COG0469	pyruvate kinase activity
B2258_RS03650	COG0494	nUDIX hydrolase
B2258_RS03670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B2258_RS03675	COG1051	belongs to the nudix hydrolase family
B2258_RS03700	COG0519	Catalyzes the synthesis of GMP from XMP
B2258_RS03725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B2258_RS03730	COG0280	phosphate acetyltransferase
B2258_RS03730	COG0857	belongs to the CobB CobQ family
B2258_RS03770	COG0799	negative regulation of ribosome biogenesis
B2258_RS03775	COG0406	alpha-ribazole phosphatase activity
B2258_RS03805	COG2011	ABC-type metal ion transport system permease component
B2258_RS03810	COG1473	amidohydrolase
B2258_RS03825	COG1882	Formate acetyltransferase
B2258_RS03885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B2258_RS03890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B2258_RS03895	COG1611	Belongs to the LOG family
B2258_RS03910	COG1053	succinate dehydrogenase
B2258_RS03915	COG0758	DNA mediated transformation
B2258_RS03945	COG2873	o-acetylhomoserine
B2258_RS03950	COG1136	(ABC) transporter
B2258_RS03955	COG0577	efflux transmembrane transporter activity
B2258_RS03955	COG1136	(ABC) transporter
B2258_RS03960	COG2197	response regulator
B2258_RS03975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B2258_RS03980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2258_RS03985	COG1126	abc transporter atp-binding protein
B2258_RS03990	COG0765	amino acid transport
B2258_RS03995	COG0765	amino acid transport
B2258_RS04000	COG0012	GTP binding
B2258_RS04020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B2258_RS04025	COG3177	Filamentation induced by cAMP protein fic
B2258_RS04070	COG1309	transcriptional regulator
B2258_RS04075	COG2814	Major facilitator Superfamily
B2258_RS04080	COG0058	SHG alpha-glucan phosphorylase activity
B2258_RS04095	COG1940	carbohydrate kinase activity
B2258_RS04095	COG1846	Transcriptional regulator
B2258_RS04110	COG0477	Major facilitator Superfamily
B2258_RS04115	COG3119	arylsulfatase activity
B2258_RS04120	COG0641	radical SAM
B2258_RS04125	COG0730	response to heat
B2258_RS04165	COG2233	PERMEase
B2258_RS04170	COG0513	Belongs to the DEAD box helicase family
B2258_RS04175	COG0366	Alpha amylase catalytic
B2258_RS04180	COG0306	phosphate transporter
B2258_RS04190	COG2197	response regulator
B2258_RS04195	COG4585	Histidine kinase
B2258_RS04200	COG1131	(ABC) transporter
B2258_RS04230	COG3340	Belongs to the peptidase S51 family
B2258_RS04235	COG1335	isochorismatase
B2258_RS04255	COG3655	Transcriptional regulator
B2258_RS04295	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B2258_RS04375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B2258_RS04395	COG0719	Fe-S assembly protein
B2258_RS04400	COG0396	ATPase activity
B2258_RS04405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B2258_RS04415	COG2151	metal-sulfur cluster biosynthetic enzyme
B2258_RS04435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B2258_RS04440	COG0537	adenosine 5'-monophosphoramidase activity
B2258_RS04465	COG1022	Amp-dependent synthetase and ligase
B2258_RS04470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B2258_RS04495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B2258_RS04505	COG2860	membrane
B2258_RS04535	COG0070	glutamate synthase
B2258_RS04535	COG0069	glutamate synthase activity
B2258_RS04535	COG0067	glutamate synthase
B2258_RS04545	COG4166	transmembrane transport
B2258_RS04560	COG0297	glycogen (starch) synthase activity
B2258_RS04565	COG1119	ATPase activity
B2258_RS04590	COG2826	transposase and inactivated derivatives, IS30 family
B2258_RS04605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B2258_RS04615	COG3266	domain, Protein
B2258_RS04615	COG0515	serine threonine protein kinase
B2258_RS04645	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B2258_RS04655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B2258_RS04675	COG0588	phosphoglycerate mutase activity
B2258_RS04685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B2258_RS04710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B2258_RS04715	COG0284	orotidine-5'-phosphate decarboxylase activity
B2258_RS04720	COG0543	2 iron, 2 sulfur cluster binding
B2258_RS04725	COG0167	dihydroorotate dehydrogenase activity
B2258_RS04745	COG0583	DNA-binding transcription factor activity
B2258_RS04760	COG0488	(ABC) transporter
B2258_RS04765	COG4221	oxidoreductase activity
B2258_RS04790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B2258_RS04815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B2258_RS04835	COG0436	Aminotransferase
B2258_RS04850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B2258_RS04950	COG0045	succinate-CoA ligase (ADP-forming) activity
B2258_RS04970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B2258_RS04975	COG1187	pseudouridine synthase activity
B2258_RS05040	COG1716	ATPase activity
B2258_RS05060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B2258_RS05075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B2258_RS05095	COG2135	peptidase activity
B2258_RS05105	COG0833	amino acid
B2258_RS05150	COG0745	RESPONSE REGULATOR receiver
B2258_RS05165	COG4181	ATPase activity
B2258_RS05210	COG1131	(ABC) transporter
B2258_RS05240	COG1131	(ABC) transporter
B2258_RS05250	COG2197	response regulator
B2258_RS05255	COG4585	Histidine kinase
B2258_RS05265	COG0577	efflux transmembrane transporter activity
B2258_RS05265	COG1136	(ABC) transporter
B2258_RS05315	COG0833	amino acid
B2258_RS05325	COG3189	MarR family transcriptional regulator
B2258_RS05360	COG0693	protein deglycase activity
B2258_RS05370	COG0575	Belongs to the CDS family
B2258_RS05410	COG0516	GMP reductase activity
B2258_RS05480	COG4585	Histidine kinase
B2258_RS05485	COG2197	response regulator
B2258_RS05500	COG0456	acetyltransferase
B2258_RS05510	COG0802	atpase or kinase
B2258_RS05535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2258_RS05540	COG0598	Magnesium transport protein CorA
B2258_RS05545	COG0406	alpha-ribazole phosphatase activity
B2258_RS05605	COG0395	ABC-type sugar transport system, permease component
B2258_RS05610	COG1175	transmembrane transport
B2258_RS05665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B2258_RS05690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B2258_RS05705	COG2207	Transcriptional regulator
B2258_RS05715	COG1201	RNA secondary structure unwinding
B2258_RS05720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2258_RS05730	COG0187	DNA topoisomerase II activity
B2258_RS05735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B2258_RS05745	COG0142	geranyltranstransferase activity
B2258_RS05765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B2258_RS05775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B2258_RS05795	COG1396	sequence-specific DNA binding
B2258_RS05800	COG1546	Belongs to the CinA family
B2258_RS05800	COG1058	Belongs to the CinA family
B2258_RS05830	COG2357	RelA SpoT domain protein
B2258_RS05845	COG2197	response regulator
B2258_RS05885	COG0708	Exodeoxyribonuclease III
B2258_RS05895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2258_RS05900	COG0601	transmembrane transport
B2258_RS05905	COG4166	transmembrane transport
B2258_RS05915	COG0577	efflux transmembrane transporter activity
B2258_RS05915	COG1136	(ABC) transporter
B2258_RS05920	COG0577	efflux transmembrane transporter activity
B2258_RS05930	COG0287	Prephenate dehydrogenase
B2258_RS05945	COG1217	gtp-binding protein TYPA
B2258_RS05955	COG1136	(ABC) transporter
B2258_RS05955	COG4591	ABC-type transport system involved in lipoprotein release permease component
B2258_RS05965	COG0477	Major facilitator Superfamily
B2258_RS05980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B2258_RS05985	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B2258_RS05995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B2258_RS06000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B2258_RS06015	COG1929	Belongs to the glycerate kinase type-1 family
B2258_RS06020	COG2610	gluconate transmembrane transporter activity
B2258_RS06025	COG3835	regulator
B2258_RS06040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B2258_RS06060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B2258_RS06070	COG2017	converts alpha-aldose to the beta-anomer
B2258_RS06075	COG2017	converts alpha-aldose to the beta-anomer
B2258_RS06085	COG1595	DNA-templated transcription, initiation
B2258_RS06105	COG1196	nuclear chromosome segregation
B2258_RS06110	COG0285	dihydrofolate synthase activity
B2258_RS06115	COG0006	proline dipeptidase activity
B2258_RS06135	COG1940	carbohydrate kinase activity
B2258_RS06140	COG1940	carbohydrate kinase activity
B2258_RS06155	COG0738	Major facilitator superfamily
B2258_RS06195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B2258_RS06205	COG0768	penicillin binding
B2258_RS06230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2258_RS06260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B2258_RS06270	COG1643	Atp-dependent helicase
B2258_RS06275	COG2814	Major facilitator Superfamily
B2258_RS06325	COG0656	L-ascorbic acid biosynthetic process
B2258_RS06335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2258_RS06345	COG4948	Mandelate Racemase Muconate Lactonizing
B2258_RS06365	COG4716	Myosin-crossreactive antigen
B2258_RS06380	COG0587	DNA-directed DNA polymerase activity
B2258_RS06415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B2258_RS06435	COG1122	ATPase activity
B2258_RS06465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B2258_RS06470	COG0351	phosphomethylpyrimidine kinase
B2258_RS06470	COG0352	thiamine-phosphate diphosphorylase activity
B2258_RS06480	COG2271	Major facilitator Superfamily
B2258_RS06490	COG2197	response regulator
B2258_RS06560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2258_RS06565	COG2814	Major facilitator Superfamily
B2258_RS06585	COG4581	dead DEAH box helicase
B2258_RS06590	COG2326	polyphosphate kinase activity
B2258_RS06595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2258_RS06600	COG1279	arginine transmembrane transporter activity
B2258_RS06610	COG0765	amino acid transport
B2258_RS06615	COG0765	amino acid transport
B2258_RS06620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2258_RS06625	COG1126	abc transporter atp-binding protein
B2258_RS06645	COG1196	nuclear chromosome segregation
B2258_RS06670	COG0477	Major facilitator Superfamily
B2258_RS06685	COG0402	S-adenosylhomocysteine deaminase activity
B2258_RS06695	COG0589	response to stress
B2258_RS06705	COG1278	Cold shock
B2258_RS06710	COG2205	protein histidine kinase activity
B2258_RS06715	COG0745	RESPONSE REGULATOR receiver
B2258_RS06735	COG1278	Cold shock
B2258_RS06750	COG0714	Associated with various cellular activities
B2258_RS06790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B2258_RS06820	COG4122	O-methyltransferase activity
B2258_RS06825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B2258_RS06835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2258_RS06840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2258_RS06840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2258_RS06840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2258_RS06855	COG1011	Hydrolase
B2258_RS06865	COG0586	Pfam SNARE associated Golgi protein
B2258_RS06870	COG0560	Phosphoserine phosphatase
B2258_RS06875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B2258_RS06940	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B2258_RS06945	COG1518	maintenance of DNA repeat elements
B2258_RS06985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2258_RS06990	COG1869	D-ribose catabolic process
B2258_RS07000	COG1172	Belongs to the binding-protein-dependent transport system permease family
B2258_RS07005	COG1129	ABC transporter
B2258_RS07025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2258_RS07030	COG1979	alcohol dehydrogenase
B2258_RS07035	COG0546	phosphoglycolate phosphatase activity
B2258_RS07045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2258_RS07050	COG0135	phosphoribosylanthranilate isomerase activity
B2258_RS07055	COG1122	ATPase activity
B2258_RS07080	COG1132	(ABC) transporter
B2258_RS07085	COG1132	(ABC) transporter
B2258_RS07125	COG1309	transcriptional regulator
B2258_RS07140	COG0602	queuosine metabolic process
B2258_RS07145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B2258_RS07145	COG1328	CTP reductase activity
B2258_RS07150	COG1570	exodeoxyribonuclease VII activity
B2258_RS07155	COG1722	exodeoxyribonuclease VII activity
B2258_RS07160	COG2249	NAD(P)H dehydrogenase (quinone) activity
B2258_RS07165	COG1022	Amp-dependent synthetase and ligase
B2258_RS07170	COG1970	mechanosensitive ion channel activity
B2258_RS07190	COG0248	Ppx GppA phosphatase
B2258_RS07195	COG0436	Aminotransferase
B2258_RS07265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B2258_RS07280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B2258_RS07285	COG0009	L-threonylcarbamoyladenylate synthase
B2258_RS07335	COG2814	Major facilitator Superfamily
B2258_RS07345	COG0242	peptide deformylase activity
B2258_RS07365	COG1940	carbohydrate kinase activity
B2258_RS07390	COG1946	Acyl-CoA thioesterase
B2258_RS07400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B2258_RS07415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B2258_RS07420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B2258_RS07445	COG1215	transferase activity, transferring glycosyl groups
B2258_RS07455	COG0463	Glycosyl transferase, family 2
B2258_RS07460	COG1454	alcohol dehydrogenase
B2258_RS07465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B2258_RS07510	COG1192	Involved in chromosome partitioning
B2258_RS07530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B2258_RS07555	COG1609	Transcriptional regulator
B2258_RS07565	COG1136	(ABC) transporter
B2258_RS07585	COG0745	RESPONSE REGULATOR receiver
B2258_RS07625	COG3942	CHAP domain
B2258_RS07625	COG1705	Flagellar rod assembly protein muramidase FlgJ
B2258_RS07710	COG3843	relaxase mobilization nuclease domain protein
B2258_RS07730	COG1475	DNA binding
B2258_RS07735	COG4585	Histidine kinase
B2258_RS07740	COG2197	response regulator
B2258_RS07760	COG1132	(ABC) transporter
B2258_RS07765	COG0577	efflux transmembrane transporter activity
B2258_RS07765	COG1136	(ABC) transporter
B2258_RS07775	COG4585	Histidine kinase
B2258_RS07805	COG4974	Belongs to the 'phage' integrase family
B2258_RS07850	COG3250	beta-galactosidase activity
B2258_RS07855	COG1609	Transcriptional regulator
B2258_RS07885	COG0577	efflux transmembrane transporter activity
B2258_RS07900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B2258_RS07920	COG0589	response to stress
B2258_RS07925	COG0791	NLP P60 protein
B2258_RS07925	COG1388	LysM domain
B2258_RS07925	COG3103	Sh3 type 3 domain protein
B2258_RS07935	COG3942	CHAP domain
B2258_RS07935	COG1705	Flagellar rod assembly protein muramidase FlgJ
B2258_RS07940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B2258_RS07950	COG5002	protein histidine kinase activity
B2258_RS07965	COG1575	Belongs to the MenA family. Type 1 subfamily
B2258_RS07970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B2258_RS07980	COG2814	Major facilitator Superfamily
B2258_RS08015	COG2197	response regulator
B2258_RS08035	COG0395	ABC-type sugar transport system, permease component
B2258_RS08040	COG1175	transmembrane transport
B2258_RS08060	COG1597	lipid kinase activity
B2258_RS08060	COG1803	Methylglyoxal synthase
B2258_RS08090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2258_RS08095	COG0328	RNA-DNA hybrid ribonuclease activity
B2258_RS08160	COG2308	Evidence 4 Homologs of previously reported genes of
B2258_RS08265	COG0255	Belongs to the universal ribosomal protein uL29 family
B2258_RS08315	COG3527	Alpha-acetolactate decarboxylase
B2258_RS08325	COG1012	belongs to the aldehyde dehydrogenase family
B2258_RS08325	COG1454	alcohol dehydrogenase
B2258_RS08365	COG1739	Uncharacterized protein family UPF0029
B2258_RS08370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2258_RS08380	COG2723	6-phospho-beta-galactosidase activity
B2258_RS08390	COG1175	transmembrane transport
B2258_RS08400	COG1609	Transcriptional regulator
B2258_RS08415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B2258_RS08430	COG0531	amino acid
B2258_RS08435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B2258_RS08515	COG2252	PERMEase
B2258_RS08540	COG0745	RESPONSE REGULATOR receiver
B2258_RS08545	COG5002	protein histidine kinase activity
B2258_RS08550	COG0477	Major facilitator Superfamily
B2258_RS08560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B2258_RS08565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B2258_RS08575	COG3250	beta-galactosidase activity
B2258_RS08580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B2258_RS08595	COG0395	ABC-type sugar transport system, permease component
B2258_RS08600	COG1175	transmembrane transport
B2258_RS08605	COG1653	transport
B2258_RS08620	COG3579	cysteine-type endopeptidase activity
B2258_RS08635	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B2258_RS08650	COG0826	peptidase U32
B2258_RS08660	COG0742	ribosomal rna small subunit methyltransferase
B2258_RS08675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B2258_RS08675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B2258_RS08680	COG2270	Major facilitator Superfamily
B2258_RS08760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B2258_RS08765	COG4770	biotin carboxylase activity
B2258_RS08770	COG1268	BioY protein
B2258_RS08805	COG0250	Participates in transcription elongation, termination and antitermination
B2258_RS08810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B2258_RS08820	COG0436	Aminotransferase
B2258_RS08850	COG1530	ribonuclease E activity
B2258_RS08855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2258_RS08865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2258_RS08885	COG4948	Mandelate Racemase Muconate Lactonizing
B2258_RS08890	COG1609	Transcriptional regulator
B2258_RS08920	COG0083	homoserine kinase activity
B2258_RS08925	COG0460	homoserine dehydrogenase
B2258_RS08930	COG1263	PTS System
B2258_RS08930	COG2190	(PTS) system
B2258_RS08930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2258_RS08935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2258_RS08935	COG1263	PTS System
B2258_RS08935	COG2190	(PTS) system
B2258_RS08950	COG1309	transcriptional regulator
B2258_RS08960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B2258_RS08965	COG0446	pyridine nucleotide-disulphide oxidoreductase
B2258_RS08975	COG0765	amino acid transport
B2258_RS08990	COG1126	abc transporter atp-binding protein
B2258_RS08995	COG0167	dihydroorotate dehydrogenase activity
B2258_RS09030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B2258_RS09035	COG0494	nUDIX hydrolase
B2258_RS09035	COG0406	alpha-ribazole phosphatase activity
B2258_RS09050	COG0395	ABC-type sugar transport system, permease component
B2258_RS09055	COG1175	transmembrane transport
B2258_RS09080	COG0584	glycerophosphoryl diester phosphodiesterase
B2258_RS09100	COG0179	Fumarylacetoacetate (FAA) hydrolase
B2258_RS09125	COG1442	glycosyl transferase family 8
B2258_RS09125	COG1216	Glycosyl transferase, family 2
B2258_RS09135	COG1368	sulfuric ester hydrolase activity
B2258_RS09140	COG0438	transferase activity, transferring glycosyl groups
B2258_RS09140	COG1216	Glycosyl transferase, family 2
B2258_RS09165	COG1088	dTDP-glucose 4,6-dehydratase activity
B2258_RS09185	COG1376	ErfK ybiS ycfS ynhG family protein
B2258_RS09195	COG1316	TRANSCRIPTIONal
B2258_RS09200	COG0577	efflux transmembrane transporter activity
B2258_RS09205	COG1129	ABC transporter
B2258_RS09225	COG0084	hydrolase, TatD family'
B2258_RS09230	COG1132	(ABC) transporter
B2258_RS09235	COG1132	(ABC) transporter
B2258_RS09260	COG4166	transmembrane transport
B2258_RS09330	COG1846	Transcriptional regulator
B2258_RS09335	COG1113	amino acid transport
B2258_RS09345	COG1136	(ABC) transporter
B2258_RS09345	COG0577	efflux transmembrane transporter activity
B2258_RS09350	COG1113	amino acid transport
B2258_RS09370	COG1609	Transcriptional regulator
B2258_RS09380	COG0588	phosphoglycerate mutase activity
B2258_RS09420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B2258_RS09425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B2258_RS09430	COG0366	Alpha amylase catalytic
B2258_RS09435	COG0395	ABC-type sugar transport system, permease component
B2258_RS09440	COG1175	transmembrane transport
B2258_RS09460	COG0037	tRNA processing
B2258_RS09460	COG0590	tRNA wobble adenosine to inosine editing
B2258_RS09465	COG0025	NhaP-type Na H and K H
B2258_RS09470	COG0730	response to heat
B2258_RS09495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B2258_RS09505	COG2190	(PTS) system
B2258_RS09505	COG1263	PTS System
B2258_RS09505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2258_RS09510	COG1263	PTS System
B2258_RS09510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B2258_RS09520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B2258_RS09560	COG3842	ATPase activity
B2258_RS09565	COG2188	Transcriptional regulator
B2258_RS09580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2258_RS09585	COG1216	Glycosyl transferase, family 2
B2258_RS09595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B2258_RS09615	COG1472	Belongs to the glycosyl hydrolase 3 family
B2258_RS09650	COG3583	domain protein
B2258_RS09670	COG0617	tRNA 3'-terminal CCA addition
B2258_RS09690	COG0492	ferredoxin-NADP+ reductase activity
B2258_RS09700	COG1192	Involved in chromosome partitioning
B2258_RS09710	COG1847	R3H domain protein