locus-tag	class	description
EH245_RS00015	COG0592	DNA-directed DNA polymerase activity
EH245_RS00030	COG0187	DNA topoisomerase II activity
EH245_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EH245_RS00045	COG1609	Transcriptional regulator
EH245_RS00055	COG3250	beta-galactosidase activity
EH245_RS00065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EH245_RS00100	COG0783	Belongs to the Dps family
EH245_RS00105	COG1253	flavin adenine dinucleotide binding
EH245_RS00170	COG2203	Gaf domain
EH245_RS00170	COG4251	negative regulation of phosphorylation
EH245_RS00170	COG5001	Diguanylate cyclase
EH245_RS00170	COG3706	GGDEF domain
EH245_RS00190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EH245_RS00215	COG0180	Tryptophanyl-tRNA synthetase
EH245_RS00225	COG2197	response regulator
EH245_RS00245	COG0058	SHG alpha-glucan phosphorylase activity
EH245_RS00285	COG0515	serine threonine protein kinase
EH245_RS00290	COG0768	penicillin binding
EH245_RS00325	COG0071	Belongs to the small heat shock protein (HSP20) family
EH245_RS00340	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EH245_RS00345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EH245_RS00380	COG0494	nUDIX hydrolase
EH245_RS00405	COG0343	queuine tRNA-ribosyltransferase activity
EH245_RS00445	COG0191	fructose-bisphosphate aldolase activity
EH245_RS00490	COG1609	Transcriptional regulator
EH245_RS00495	COG0477	Major facilitator Superfamily
EH245_RS00520	COG0366	Alpha amylase catalytic
EH245_RS00525	COG1609	Transcriptional regulator
EH245_RS00555	COG0366	Alpha amylase catalytic
EH245_RS00565	COG1175	transmembrane transport
EH245_RS00570	COG3833	ABC-type maltose transport systems, permease component
EH245_RS00575	COG1523	belongs to the glycosyl hydrolase 13 family
EH245_RS00590	COG1609	Transcriptional regulator
EH245_RS00610	COG0789	Transcriptional regulator
EH245_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
EH245_RS00630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EH245_RS00635	COG0586	Pfam SNARE associated Golgi protein
EH245_RS00680	COG1309	transcriptional regulator
EH245_RS00745	COG0527	aspartate kinase activity
EH245_RS00765	COG1940	carbohydrate kinase activity
EH245_RS00770	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EH245_RS00780	COG0747	negative chemotaxis
EH245_RS00790	COG0444	Belongs to the ABC transporter superfamily
EH245_RS00795	COG4608	Belongs to the ABC transporter superfamily
EH245_RS00800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EH245_RS00825	COG2186	Transcriptional regulator
EH245_RS00860	COG1754	DNA topoisomerase type I activity
EH245_RS00860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EH245_RS00870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EH245_RS00885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EH245_RS00970	COG0672	)-iron permease
EH245_RS00975	COG3470	protein probably involved in high-affinity Fe2 transport
EH245_RS00990	COG0577	efflux transmembrane transporter activity
EH245_RS00995	COG1136	(ABC) transporter
EH245_RS01030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EH245_RS01035	COG0363	glucosamine-6-phosphate deaminase activity
EH245_RS01065	COG1216	Glycosyl transferase, family 2
EH245_RS01065	COG1442	glycosyl transferase family 8
EH245_RS01070	COG1309	transcriptional regulator
EH245_RS01090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EH245_RS01100	COG0305	Participates in initiation and elongation during chromosome replication
EH245_RS01105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EH245_RS01110	COG3442	glutamine amidotransferase
EH245_RS01135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EH245_RS01170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EH245_RS01180	COG1937	Protein conserved in bacteria
EH245_RS01200	COG1131	(ABC) transporter
EH245_RS01275	COG2182	Extracellular solute-binding protein
EH245_RS01285	COG0395	ABC-type sugar transport system, permease component
EH245_RS01330	COG0745	RESPONSE REGULATOR receiver
EH245_RS01345	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EH245_RS01370	COG0356	it plays a direct role in the translocation of protons across the membrane
EH245_RS01405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EH245_RS01445	COG0251	oxidation-reduction process
EH245_RS01480	COG3842	ATPase activity
EH245_RS01495	COG1027	Aspartate ammonia-lyase
EH245_RS01510	COG0730	response to heat
EH245_RS01515	COG0641	radical SAM
EH245_RS01520	COG1609	Transcriptional regulator
EH245_RS01525	COG3119	arylsulfatase activity
EH245_RS01545	COG0395	ABC-type sugar transport system, permease component
EH245_RS01550	COG1373	ATPase (AAA superfamily
EH245_RS01570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EH245_RS01590	COG0569	domain protein
EH245_RS01590	COG0475	glutathione-regulated potassium exporter activity
EH245_RS01640	COG2176	DNA-directed DNA polymerase activity
EH245_RS01660	COG2826	transposase and inactivated derivatives, IS30 family
EH245_RS01700	COG1704	LemA family
EH245_RS01735	COG1837	Belongs to the UPF0109 family
EH245_RS01770	COG0519	Catalyzes the synthesis of GMP from XMP
EH245_RS01775	COG0488	(ABC) transporter
EH245_RS01780	COG1487	ribonuclease activity
EH245_RS01790	COG0440	acetolactate synthase activity
EH245_RS01830	COG0667	Aldo Keto reductase
EH245_RS01970	COG1116	anion transmembrane transporter activity
EH245_RS01985	COG3775	system Galactitol-specific IIC component
EH245_RS02015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EH245_RS02020	COG1609	Transcriptional regulator
EH245_RS02035	COG0477	Major facilitator Superfamily
EH245_RS02035	COG2814	Major facilitator Superfamily
EH245_RS02045	COG4988	ABC transporter
EH245_RS02060	COG1653	transport
EH245_RS02080	COG0656	L-ascorbic acid biosynthetic process
EH245_RS02100	COG2814	Major facilitator Superfamily
EH245_RS02115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EH245_RS02130	COG0438	transferase activity, transferring glycosyl groups
EH245_RS02135	COG0438	transferase activity, transferring glycosyl groups
EH245_RS02155	COG0463	Glycosyl transferase, family 2
EH245_RS02160	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EH245_RS02195	COG0489	protein tyrosine kinase activity
EH245_RS02255	COG0095	Lipoate-protein ligase
EH245_RS02260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EH245_RS02265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EH245_RS02265	COG4499	WXG100 protein secretion system (Wss), protein YukC
EH245_RS02270	COG1902	pentaerythritol trinitrate reductase activity
EH245_RS02275	COG0167	dihydroorotate dehydrogenase activity
EH245_RS02280	COG1349	DNA-binding transcription factor activity
EH245_RS02290	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EH245_RS02315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EH245_RS02350	COG0714	Associated with various cellular activities
EH245_RS02365	COG0210	DNA helicase
EH245_RS02385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EH245_RS02410	COG1175	transmembrane transport
EH245_RS02415	COG0395	ABC-type sugar transport system, permease component
EH245_RS02425	COG2207	Transcriptional regulator
EH245_RS02455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EH245_RS02460	COG2884	Cell division ATP-binding protein ftsE
EH245_RS02465	COG2177	Part of the ABC transporter FtsEX involved in
EH245_RS02470	COG1388	LysM domain
EH245_RS02470	COG3942	CHAP domain
EH245_RS02495	COG1126	abc transporter atp-binding protein
EH245_RS02505	COG0564	pseudouridine synthase activity
EH245_RS02510	COG1609	Transcriptional regulator
EH245_RS02520	COG1175	transmembrane transport
EH245_RS02525	COG0395	ABC-type sugar transport system, permease component
EH245_RS02535	COG1653	transport
EH245_RS02550	COG4166	transmembrane transport
EH245_RS02555	COG0601	transmembrane transport
EH245_RS02560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EH245_RS02570	COG4608	Belongs to the ABC transporter superfamily
EH245_RS02580	COG0626	cystathionine gamma-synthase activity
EH245_RS02585	COG0514	ATP-dependent DNA helicase (RecQ)
EH245_RS02600	COG1609	Transcriptional regulator
EH245_RS02630	COG0395	ABC-type sugar transport system, permease component
EH245_RS02650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EH245_RS02655	COG3265	gluconokinase activity
EH245_RS02660	COG4948	Mandelate Racemase Muconate Lactonizing
EH245_RS02665	COG0246	Mannitol dehydrogenase
EH245_RS02670	COG1904	glucuronate isomerase
EH245_RS02685	COG1609	Transcriptional regulator
EH245_RS02690	COG0531	amino acid
EH245_RS02695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EH245_RS02705	COG0358	DNA primase activity
EH245_RS02730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EH245_RS02735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EH245_RS02770	COG1609	Transcriptional regulator
EH245_RS02775	COG0366	Alpha amylase catalytic
EH245_RS02805	COG0577	efflux transmembrane transporter activity
EH245_RS02805	COG1136	(ABC) transporter
EH245_RS02815	COG0577	efflux transmembrane transporter activity
EH245_RS02815	COG0577	efflux transmembrane transporter activity
EH245_RS02820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EH245_RS02825	COG0604	alcohol dehydrogenase
EH245_RS02830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EH245_RS02835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EH245_RS02860	COG1012	belongs to the aldehyde dehydrogenase family
EH245_RS02880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EH245_RS02945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EH245_RS02960	COG0436	Aminotransferase
EH245_RS02980	COG0385	Bile acid
EH245_RS03015	COG0583	DNA-binding transcription factor activity
EH245_RS03045	COG0789	Transcriptional regulator
EH245_RS03050	COG1063	alcohol dehydrogenase
EH245_RS03070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EH245_RS03095	COG0110	maltose O-acetyltransferase activity
EH245_RS03100	COG0110	maltose O-acetyltransferase activity
EH245_RS03110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EH245_RS03120	COG4106	trans-aconitate 2-methyltransferase activity
EH245_RS03130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EH245_RS03145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EH245_RS03150	COG1125	glycine betaine transport
EH245_RS03150	COG0517	IMP dehydrogenase activity
EH245_RS03155	COG1174	glycine betaine transport
EH245_RS03175	COG1376	ErfK ybiS ycfS ynhG family protein
EH245_RS03180	COG0390	transport system, permease component
EH245_RS03185	COG1132	(ABC) transporter
EH245_RS03210	COG0284	orotidine-5'-phosphate decarboxylase activity
EH245_RS03220	COG2176	DNA-directed DNA polymerase activity
EH245_RS03240	COG1388	LysM domain
EH245_RS03240	COG3942	CHAP domain
EH245_RS03455	COG1475	DNA binding
EH245_RS03530	COG4974	Belongs to the 'phage' integrase family
EH245_RS03540	COG0626	cystathionine gamma-synthase activity
EH245_RS03585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EH245_RS03665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EH245_RS03675	COG0436	Aminotransferase
EH245_RS03680	COG1122	ATPase activity
EH245_RS03730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EH245_RS03735	COG4721	ABC-type cobalt transport system, permease component
EH245_RS03740	COG1122	ATPase activity
EH245_RS03750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EH245_RS03820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EH245_RS03825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EH245_RS03875	COG0497	DNA recombination
EH245_RS03880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EH245_RS03915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EH245_RS03940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EH245_RS03950	COG0701	Predicted permease
EH245_RS03985	COG0667	Aldo Keto reductase
EH245_RS04020	COG1760	l-serine dehydratase
EH245_RS04030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EH245_RS04055	COG1316	TRANSCRIPTIONal
EH245_RS04090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EH245_RS04095	COG2205	protein histidine kinase activity
EH245_RS04100	COG0745	RESPONSE REGULATOR receiver
EH245_RS04120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EH245_RS04125	COG1121	(ABC) transporter
EH245_RS04140	COG0539	negative regulation of cytoplasmic translation
EH245_RS04160	COG0469	pyruvate kinase activity
EH245_RS04165	COG0494	nUDIX hydrolase
EH245_RS04185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EH245_RS04190	COG1051	belongs to the nudix hydrolase family
EH245_RS04240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EH245_RS04245	COG0857	belongs to the CobB CobQ family
EH245_RS04245	COG0280	phosphate acetyltransferase
EH245_RS04295	COG3340	Belongs to the peptidase S51 family
EH245_RS04335	COG0799	negative regulation of ribosome biogenesis
EH245_RS04340	COG0406	alpha-ribazole phosphatase activity
EH245_RS04370	COG2011	ABC-type metal ion transport system permease component
EH245_RS04375	COG1473	amidohydrolase
EH245_RS04390	COG1882	Formate acetyltransferase
EH245_RS04450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EH245_RS04455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EH245_RS04460	COG1611	Belongs to the LOG family
EH245_RS04475	COG1053	succinate dehydrogenase
EH245_RS04480	COG0758	DNA mediated transformation
EH245_RS04510	COG2873	o-acetylhomoserine
EH245_RS04515	COG1136	(ABC) transporter
EH245_RS04520	COG0577	efflux transmembrane transporter activity
EH245_RS04520	COG1136	(ABC) transporter
EH245_RS04525	COG2197	response regulator
EH245_RS04540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EH245_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EH245_RS04550	COG1126	abc transporter atp-binding protein
EH245_RS04555	COG0765	amino acid transport
EH245_RS04560	COG0765	amino acid transport
EH245_RS04565	COG0012	GTP binding
EH245_RS04585	COG1309	transcriptional regulator
EH245_RS04605	COG2814	Major facilitator Superfamily
EH245_RS04625	COG2239	Acts as a magnesium transporter
EH245_RS04655	COG1846	Transcriptional regulator
EH245_RS04655	COG1940	carbohydrate kinase activity
EH245_RS04670	COG0477	Major facilitator Superfamily
EH245_RS04675	COG3119	arylsulfatase activity
EH245_RS04680	COG0641	radical SAM
EH245_RS04685	COG0730	response to heat
EH245_RS04735	COG2233	PERMEase
EH245_RS04740	COG0513	Belongs to the DEAD box helicase family
EH245_RS04745	COG0366	Alpha amylase catalytic
EH245_RS04750	COG0306	phosphate transporter
EH245_RS04760	COG2197	response regulator
EH245_RS04765	COG4585	Histidine kinase
EH245_RS04770	COG1131	(ABC) transporter
EH245_RS04800	COG3340	Belongs to the peptidase S51 family
EH245_RS04805	COG1335	isochorismatase
EH245_RS04825	COG3655	Transcriptional regulator
EH245_RS04855	COG0577	efflux transmembrane transporter activity
EH245_RS04855	COG1136	(ABC) transporter
EH245_RS04865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EH245_RS04940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EH245_RS04965	COG0719	Fe-S assembly protein
EH245_RS04970	COG0396	ATPase activity
EH245_RS04975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EH245_RS04985	COG2151	metal-sulfur cluster biosynthetic enzyme
EH245_RS05005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EH245_RS05010	COG0537	adenosine 5'-monophosphoramidase activity
EH245_RS05035	COG1022	Amp-dependent synthetase and ligase
EH245_RS05040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EH245_RS05065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EH245_RS05075	COG2860	membrane
EH245_RS05115	COG0070	glutamate synthase
EH245_RS05115	COG0069	glutamate synthase activity
EH245_RS05115	COG0067	glutamate synthase
EH245_RS05130	COG4166	transmembrane transport
EH245_RS05145	COG0297	glycogen (starch) synthase activity
EH245_RS05150	COG1119	ATPase activity
EH245_RS05155	COG0561	phosphatase activity
EH245_RS05155	COG0561	phosphatase activity
EH245_RS05195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EH245_RS05230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EH245_RS05255	COG0588	phosphoglycerate mutase activity
EH245_RS05265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EH245_RS05290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EH245_RS05295	COG0284	orotidine-5'-phosphate decarboxylase activity
EH245_RS05300	COG0543	2 iron, 2 sulfur cluster binding
EH245_RS05305	COG0167	dihydroorotate dehydrogenase activity
EH245_RS05325	COG0583	DNA-binding transcription factor activity
EH245_RS05340	COG0488	(ABC) transporter
EH245_RS05345	COG4221	oxidoreductase activity
EH245_RS05380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EH245_RS05405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EH245_RS05420	COG0436	Aminotransferase
EH245_RS05435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EH245_RS05535	COG0045	succinate-CoA ligase (ADP-forming) activity
EH245_RS05560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EH245_RS05565	COG1187	pseudouridine synthase activity
EH245_RS05630	COG1716	ATPase activity
EH245_RS05665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EH245_RS05680	COG0133	tryptophan synthase activity
EH245_RS05685	COG2135	peptidase activity
EH245_RS05695	COG0833	amino acid
EH245_RS05780	COG1131	(ABC) transporter
EH245_RS05790	COG2746	aminoglycoside 3-N-acetyltransferase activity
EH245_RS05805	COG2197	response regulator
EH245_RS05855	COG1373	ATPase (AAA superfamily
EH245_RS05880	COG1051	belongs to the nudix hydrolase family
EH245_RS05885	COG0706	membrane insertase activity
EH245_RS05900	COG0833	amino acid
EH245_RS05910	COG3189	MarR family transcriptional regulator
EH245_RS05955	COG0575	Belongs to the CDS family
EH245_RS06000	COG0516	GMP reductase activity
EH245_RS06035	COG0456	acetyltransferase
EH245_RS06045	COG0802	atpase or kinase
EH245_RS06070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EH245_RS06075	COG0598	Magnesium transport protein CorA
EH245_RS06080	COG0406	alpha-ribazole phosphatase activity
EH245_RS06140	COG0395	ABC-type sugar transport system, permease component
EH245_RS06145	COG1175	transmembrane transport
EH245_RS06185	COG2977	Belongs to the P-Pant transferase superfamily
EH245_RS06200	COG0477	Major facilitator Superfamily
EH245_RS06235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EH245_RS06260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EH245_RS06270	COG2207	Transcriptional regulator
EH245_RS06280	COG1201	RNA secondary structure unwinding
EH245_RS06285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EH245_RS06295	COG0187	DNA topoisomerase II activity
EH245_RS06300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EH245_RS06310	COG0142	geranyltranstransferase activity
EH245_RS06330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EH245_RS06340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EH245_RS06365	COG1396	sequence-specific DNA binding
EH245_RS06370	COG1546	Belongs to the CinA family
EH245_RS06370	COG1058	Belongs to the CinA family
EH245_RS06400	COG2357	RelA SpoT domain protein
EH245_RS06430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EH245_RS06455	COG0708	Exodeoxyribonuclease III
EH245_RS06465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EH245_RS06470	COG0601	transmembrane transport
EH245_RS06475	COG4166	transmembrane transport
EH245_RS06485	COG1136	(ABC) transporter
EH245_RS06485	COG0577	efflux transmembrane transporter activity
EH245_RS06490	COG0577	efflux transmembrane transporter activity
EH245_RS06500	COG0287	Prephenate dehydrogenase
EH245_RS06515	COG1217	gtp-binding protein TYPA
EH245_RS06525	COG4591	ABC-type transport system involved in lipoprotein release permease component
EH245_RS06525	COG1136	(ABC) transporter
EH245_RS06535	COG0477	Major facilitator Superfamily
EH245_RS06550	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EH245_RS06555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EH245_RS06565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EH245_RS06570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EH245_RS06585	COG1929	Belongs to the glycerate kinase type-1 family
EH245_RS06600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EH245_RS06620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EH245_RS06630	COG2017	converts alpha-aldose to the beta-anomer
EH245_RS06635	COG2017	converts alpha-aldose to the beta-anomer
EH245_RS06645	COG1595	DNA-templated transcription, initiation
EH245_RS06665	COG1196	nuclear chromosome segregation
EH245_RS06670	COG0285	dihydrofolate synthase activity
EH245_RS06675	COG0006	proline dipeptidase activity
EH245_RS06695	COG1940	carbohydrate kinase activity
EH245_RS06700	COG1940	carbohydrate kinase activity
EH245_RS06755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EH245_RS06765	COG0768	penicillin binding
EH245_RS06790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EH245_RS06820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EH245_RS06830	COG1643	Atp-dependent helicase
EH245_RS06835	COG2814	Major facilitator Superfamily
EH245_RS06885	COG0656	L-ascorbic acid biosynthetic process
EH245_RS06895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EH245_RS06910	COG4948	Mandelate Racemase Muconate Lactonizing
EH245_RS06920	COG0395	ABC-type sugar transport system, permease component
EH245_RS06925	COG1175	transmembrane transport
EH245_RS06935	COG3657	addiction module killer protein
EH245_RS06975	COG0601	transmembrane transport
EH245_RS07005	COG4716	Myosin-crossreactive antigen
EH245_RS07020	COG0587	DNA-directed DNA polymerase activity
EH245_RS07060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EH245_RS07085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EH245_RS07090	COG0351	phosphomethylpyrimidine kinase
EH245_RS07090	COG0352	thiamine-phosphate diphosphorylase activity
EH245_RS07105	COG2271	Major facilitator Superfamily
EH245_RS07115	COG2197	response regulator
EH245_RS07185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EH245_RS07190	COG2814	Major facilitator Superfamily
EH245_RS07195	COG0745	RESPONSE REGULATOR receiver
EH245_RS07205	COG4581	dead DEAH box helicase
EH245_RS07210	COG2326	polyphosphate kinase activity
EH245_RS07215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EH245_RS07220	COG1279	arginine transmembrane transporter activity
EH245_RS07230	COG0765	amino acid transport
EH245_RS07235	COG0765	amino acid transport
EH245_RS07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EH245_RS07245	COG1126	abc transporter atp-binding protein
EH245_RS07265	COG1196	nuclear chromosome segregation
EH245_RS07280	COG0477	Major facilitator Superfamily
EH245_RS07295	COG0402	S-adenosylhomocysteine deaminase activity
EH245_RS07305	COG0589	response to stress
EH245_RS07315	COG1278	Cold shock
EH245_RS07320	COG2205	protein histidine kinase activity
EH245_RS07325	COG0745	RESPONSE REGULATOR receiver
EH245_RS07345	COG1278	Cold shock
EH245_RS07360	COG0714	Associated with various cellular activities
EH245_RS07405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EH245_RS07435	COG4122	O-methyltransferase activity
EH245_RS07440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EH245_RS07450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EH245_RS07455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EH245_RS07455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EH245_RS07455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EH245_RS07470	COG1011	Hydrolase
EH245_RS07480	COG0586	Pfam SNARE associated Golgi protein
EH245_RS07485	COG0560	Phosphoserine phosphatase
EH245_RS07490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EH245_RS07540	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EH245_RS07545	COG1518	maintenance of DNA repeat elements
EH245_RS07600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EH245_RS07600	COG1116	anion transmembrane transporter activity
EH245_RS07615	COG1228	amidohydrolase
EH245_RS07620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EH245_RS07625	COG1122	ATPase activity
EH245_RS07635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EH245_RS07670	COG1132	(ABC) transporter
EH245_RS07675	COG1132	(ABC) transporter
EH245_RS07685	COG1472	Belongs to the glycosyl hydrolase 3 family
EH245_RS07740	COG2211	Major facilitator Superfamily
EH245_RS07755	COG2211	Major facilitator Superfamily
EH245_RS07765	COG1136	(ABC) transporter
EH245_RS07780	COG3850	Histidine kinase
EH245_RS07780	COG5002	protein histidine kinase activity
EH245_RS07795	COG1285	pathogenesis
EH245_RS07800	COG2211	Major facilitator Superfamily
EH245_RS07805	COG3250	beta-galactosidase activity
EH245_RS07815	COG1609	Transcriptional regulator
EH245_RS07825	COG0154	amidase activity
EH245_RS07835	COG2182	Extracellular solute-binding protein
EH245_RS07855	COG1309	transcriptional regulator
EH245_RS07870	COG0602	queuosine metabolic process
EH245_RS07875	COG1328	CTP reductase activity
EH245_RS07875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EH245_RS07880	COG1570	exodeoxyribonuclease VII activity
EH245_RS07885	COG1722	exodeoxyribonuclease VII activity
EH245_RS07890	COG2249	NAD(P)H dehydrogenase (quinone) activity
EH245_RS07895	COG1022	Amp-dependent synthetase and ligase
EH245_RS07900	COG1970	mechanosensitive ion channel activity
EH245_RS07920	COG0248	Ppx GppA phosphatase
EH245_RS07925	COG0436	Aminotransferase
EH245_RS07995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EH245_RS08010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EH245_RS08015	COG0009	L-threonylcarbamoyladenylate synthase
EH245_RS08070	COG2814	Major facilitator Superfamily
EH245_RS08080	COG0242	peptide deformylase activity
EH245_RS08100	COG1940	carbohydrate kinase activity
EH245_RS08125	COG1946	Acyl-CoA thioesterase
EH245_RS08135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EH245_RS08140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EH245_RS08150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EH245_RS08155	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EH245_RS08180	COG1215	transferase activity, transferring glycosyl groups
EH245_RS08190	COG0463	Glycosyl transferase, family 2
EH245_RS08195	COG1454	alcohol dehydrogenase
EH245_RS08200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EH245_RS08250	COG0488	(ABC) transporter
EH245_RS08295	COG3250	beta-galactosidase activity
EH245_RS08305	COG1609	Transcriptional regulator
EH245_RS08340	COG0577	efflux transmembrane transporter activity
EH245_RS08360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EH245_RS08380	COG0589	response to stress
EH245_RS08385	COG3103	Sh3 type 3 domain protein
EH245_RS08385	COG1388	LysM domain
EH245_RS08385	COG0791	NLP P60 protein
EH245_RS08395	COG3942	CHAP domain
EH245_RS08395	COG1705	Flagellar rod assembly protein muramidase FlgJ
EH245_RS08400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EH245_RS08410	COG5002	protein histidine kinase activity
EH245_RS08425	COG1575	Belongs to the MenA family. Type 1 subfamily
EH245_RS08430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EH245_RS08445	COG2814	Major facilitator Superfamily
EH245_RS08480	COG2197	response regulator
EH245_RS08500	COG0395	ABC-type sugar transport system, permease component
EH245_RS08505	COG1175	transmembrane transport
EH245_RS08525	COG1597	lipid kinase activity
EH245_RS08525	COG1803	Methylglyoxal synthase
EH245_RS08555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EH245_RS08560	COG0328	RNA-DNA hybrid ribonuclease activity
EH245_RS08630	COG2308	Evidence 4 Homologs of previously reported genes of
EH245_RS08735	COG0255	Belongs to the universal ribosomal protein uL29 family
EH245_RS08785	COG3527	Alpha-acetolactate decarboxylase
EH245_RS08795	COG1012	belongs to the aldehyde dehydrogenase family
EH245_RS08795	COG1454	alcohol dehydrogenase
EH245_RS08805	COG1063	alcohol dehydrogenase
EH245_RS08860	COG1739	Uncharacterized protein family UPF0029
EH245_RS08865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EH245_RS08885	COG1175	transmembrane transport
EH245_RS08895	COG1609	Transcriptional regulator
EH245_RS08910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EH245_RS08925	COG0531	amino acid
EH245_RS08930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EH245_RS08975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EH245_RS09025	COG2252	PERMEase
EH245_RS09050	COG0745	RESPONSE REGULATOR receiver
EH245_RS09055	COG5002	protein histidine kinase activity
EH245_RS09060	COG0477	Major facilitator Superfamily
EH245_RS09065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EH245_RS09070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EH245_RS09080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EH245_RS09095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EH245_RS09110	COG0826	peptidase U32
EH245_RS09120	COG0742	ribosomal rna small subunit methyltransferase
EH245_RS09135	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EH245_RS09135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EH245_RS09140	COG2270	Major facilitator Superfamily
EH245_RS09145	COG0789	Transcriptional regulator
EH245_RS09240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EH245_RS09245	COG4770	biotin carboxylase activity
EH245_RS09250	COG1268	BioY protein
EH245_RS09290	COG0250	Participates in transcription elongation, termination and antitermination
EH245_RS09295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EH245_RS09305	COG0436	Aminotransferase
EH245_RS09335	COG1530	ribonuclease E activity
EH245_RS09340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EH245_RS09350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EH245_RS09375	COG4948	Mandelate Racemase Muconate Lactonizing
EH245_RS09380	COG1609	Transcriptional regulator
EH245_RS09390	COG1136	(ABC) transporter
EH245_RS09410	COG0083	homoserine kinase activity
EH245_RS09415	COG0460	homoserine dehydrogenase
EH245_RS09420	COG1263	PTS System
EH245_RS09420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EH245_RS09425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EH245_RS09425	COG1263	PTS System
EH245_RS09425	COG2190	(PTS) system
EH245_RS09440	COG1309	transcriptional regulator
EH245_RS09450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EH245_RS09455	COG0446	pyridine nucleotide-disulphide oxidoreductase
EH245_RS09465	COG0765	amino acid transport
EH245_RS09480	COG1126	abc transporter atp-binding protein
EH245_RS09485	COG0167	dihydroorotate dehydrogenase activity
EH245_RS09530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EH245_RS09535	COG0406	alpha-ribazole phosphatase activity
EH245_RS09535	COG0494	nUDIX hydrolase
EH245_RS09555	COG0395	ABC-type sugar transport system, permease component
EH245_RS09560	COG1175	transmembrane transport
EH245_RS09685	COG0584	glycerophosphoryl diester phosphodiesterase
EH245_RS09710	COG0179	Fumarylacetoacetate (FAA) hydrolase
EH245_RS09730	COG3311	Transcriptional regulator
EH245_RS09745	COG1737	Transcriptional regulator
EH245_RS09750	COG1172	Belongs to the binding-protein-dependent transport system permease family
EH245_RS09755	COG1172	Belongs to the binding-protein-dependent transport system permease family
EH245_RS09760	COG1129	ABC transporter
EH245_RS09770	COG1070	Carbohydrate kinase
EH245_RS09785	COG1216	Glycosyl transferase, family 2
EH245_RS09785	COG1442	glycosyl transferase family 8
EH245_RS09795	COG1368	sulfuric ester hydrolase activity
EH245_RS09800	COG0438	transferase activity, transferring glycosyl groups
EH245_RS09800	COG1216	Glycosyl transferase, family 2
EH245_RS09825	COG1088	dTDP-glucose 4,6-dehydratase activity
EH245_RS09845	COG1316	TRANSCRIPTIONal
EH245_RS09850	COG0577	efflux transmembrane transporter activity
EH245_RS09855	COG1129	ABC transporter
EH245_RS09880	COG0084	hydrolase, TatD family'
EH245_RS09885	COG1132	(ABC) transporter
EH245_RS09890	COG1132	(ABC) transporter
EH245_RS09915	COG4166	transmembrane transport
EH245_RS10000	COG1846	Transcriptional regulator
EH245_RS10010	COG1113	amino acid transport
EH245_RS10025	COG1113	amino acid transport
EH245_RS10045	COG1609	Transcriptional regulator
EH245_RS10055	COG0588	phosphoglycerate mutase activity
EH245_RS10100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EH245_RS10105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EH245_RS10110	COG0366	Alpha amylase catalytic
EH245_RS10115	COG0395	ABC-type sugar transport system, permease component
EH245_RS10120	COG1175	transmembrane transport
EH245_RS10145	COG0590	tRNA wobble adenosine to inosine editing
EH245_RS10145	COG0037	tRNA processing
EH245_RS10150	COG0025	NhaP-type Na H and K H
EH245_RS10155	COG0730	response to heat
EH245_RS10180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EH245_RS10200	COG1733	regulation of RNA biosynthetic process
EH245_RS10205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EH245_RS10225	COG3842	ATPase activity
EH245_RS10230	COG2188	Transcriptional regulator
EH245_RS10245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EH245_RS10250	COG1215	transferase activity, transferring glycosyl groups
EH245_RS10260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EH245_RS10305	COG3583	domain protein
EH245_RS10325	COG0617	tRNA 3'-terminal CCA addition
EH245_RS10345	COG0492	ferredoxin-NADP+ reductase activity
EH245_RS10350	COG1475	DNA binding
EH245_RS10355	COG1192	Involved in chromosome partitioning
EH245_RS10365	COG1847	R3H domain protein