locus-tag	class	description
BBCT_RS00010	COG0592	DNA-directed DNA polymerase activity
BBCT_RS00025	COG0187	DNA topoisomerase II activity
BBCT_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBCT_RS00040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBCT_RS00045	COG1970	mechanosensitive ion channel activity
BBCT_RS00070	COG0039	L-malate dehydrogenase activity
BBCT_RS00075	COG1253	flavin adenine dinucleotide binding
BBCT_RS00085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BBCT_RS00095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBCT_RS00100	COG0180	Tryptophanyl-tRNA synthetase
BBCT_RS00115	COG0058	SHG alpha-glucan phosphorylase activity
BBCT_RS00145	COG3764	Sortase (surface protein transpeptidase)
BBCT_RS00160	COG0515	serine threonine protein kinase
BBCT_RS00165	COG0768	penicillin binding
BBCT_RS00200	COG2197	response regulator
BBCT_RS00220	COG0343	queuine tRNA-ribosyltransferase activity
BBCT_RS00235	COG0252	asparaginase activity
BBCT_RS00270	COG0191	fructose-bisphosphate aldolase activity
BBCT_RS00315	COG0477	Major facilitator Superfamily
BBCT_RS00340	COG1113	amino acid transport
BBCT_RS00350	COG0569	domain protein
BBCT_RS00350	COG0475	glutathione-regulated potassium exporter activity
BBCT_RS00380	COG1113	amino acid transport
BBCT_RS00400	COG0667	Aldo Keto reductase
BBCT_RS00425	COG0672	)-iron permease
BBCT_RS00430	COG3470	protein probably involved in high-affinity Fe2 transport
BBCT_RS00480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBCT_RS00495	COG1215	transferase activity, transferring glycosyl groups
BBCT_RS00500	COG1309	transcriptional regulator
BBCT_RS00525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BBCT_RS00530	COG0305	Participates in initiation and elongation during chromosome replication
BBCT_RS00535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBCT_RS00540	COG3442	glutamine amidotransferase
BBCT_RS00565	COG1175	transmembrane transport
BBCT_RS00570	COG0395	ABC-type sugar transport system, permease component
BBCT_RS00590	COG0584	glycerophosphoryl diester phosphodiesterase
BBCT_RS00610	COG0406	alpha-ribazole phosphatase activity
BBCT_RS00610	COG0494	nUDIX hydrolase
BBCT_RS00615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BBCT_RS00660	COG1309	transcriptional regulator
BBCT_RS00680	COG0527	aspartate kinase activity
BBCT_RS00705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBCT_RS00710	COG1260	myo-inositol-1-phosphate synthase
BBCT_RS00725	COG1754	DNA topoisomerase type I activity
BBCT_RS00725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBCT_RS00735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BBCT_RS00740	COG1609	Transcriptional regulator
BBCT_RS00745	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBCT_RS00745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBCT_RS00750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBCT_RS00835	COG0167	dihydroorotate dehydrogenase activity
BBCT_RS00840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBCT_RS00880	COG1309	transcriptional regulator
BBCT_RS00885	COG0436	Aminotransferase
BBCT_RS00890	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BBCT_RS00900	COG3265	gluconokinase activity
BBCT_RS00910	COG2270	Major facilitator Superfamily
BBCT_RS00925	COG0742	ribosomal rna small subunit methyltransferase
BBCT_RS00940	COG1837	Belongs to the UPF0109 family
BBCT_RS00980	COG0488	(ABC) transporter
BBCT_RS01035	COG0667	Aldo Keto reductase
BBCT_RS01040	COG0789	Transcriptional regulator
BBCT_RS01065	COG2348	transferase activity, transferring amino-acyl groups
BBCT_RS01095	COG0681	Belongs to the peptidase S26 family
BBCT_RS01100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBCT_RS01105	COG1136	(ABC) transporter
BBCT_RS01120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBCT_RS01125	COG1530	ribonuclease E activity
BBCT_RS01150	COG0436	Aminotransferase
BBCT_RS01165	COG0250	Participates in transcription elongation, termination and antitermination
BBCT_RS01190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BBCT_RS01190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BBCT_RS01195	COG1268	BioY protein
BBCT_RS01200	COG4770	biotin carboxylase activity
BBCT_RS01205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBCT_RS01245	COG1704	LemA family
BBCT_RS01260	COG0826	peptidase U32
BBCT_RS01265	COG1496	oxidoreductase activity
BBCT_RS01275	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BBCT_RS01285	COG3579	cysteine-type endopeptidase activity
BBCT_RS01290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBCT_RS01295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBCT_RS01305	COG5002	protein histidine kinase activity
BBCT_RS01310	COG0745	RESPONSE REGULATOR receiver
BBCT_RS01340	COG2252	PERMEase
BBCT_RS01380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBCT_RS01420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBCT_RS01425	COG0531	amino acid
BBCT_RS01440	COG4166	transmembrane transport
BBCT_RS01445	COG0601	transmembrane transport
BBCT_RS01450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBCT_RS01455	COG0444	Belongs to the ABC transporter superfamily
BBCT_RS01460	COG4608	Belongs to the ABC transporter superfamily
BBCT_RS01465	COG3507	Belongs to the glycosyl hydrolase 43 family
BBCT_RS01480	COG3507	Belongs to the glycosyl hydrolase 43 family
BBCT_RS01485	COG2272	Belongs to the type-B carboxylesterase lipase family
BBCT_RS01495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBCT_RS01505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBCT_RS01510	COG1739	Uncharacterized protein family UPF0029
BBCT_RS01555	COG1063	alcohol dehydrogenase
BBCT_RS01565	COG1454	alcohol dehydrogenase
BBCT_RS01565	COG1012	belongs to the aldehyde dehydrogenase family
BBCT_RS01615	COG0255	Belongs to the universal ribosomal protein uL29 family
BBCT_RS01755	COG0196	riboflavin kinase activity
BBCT_RS01775	COG0328	RNA-DNA hybrid ribonuclease activity
BBCT_RS01790	COG3711	transcriptional antiterminator
BBCT_RS01795	COG1597	lipid kinase activity
BBCT_RS01795	COG1803	Methylglyoxal synthase
BBCT_RS01810	COG1397	ADP-ribosylglycohydrolase
BBCT_RS01860	COG2814	Major facilitator Superfamily
BBCT_RS01870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBCT_RS01875	COG1575	Belongs to the MenA family. Type 1 subfamily
BBCT_RS01885	COG4716	Myosin-crossreactive antigen
BBCT_RS01890	COG0704	Plays a role in the regulation of phosphate uptake
BBCT_RS01895	COG5002	protein histidine kinase activity
BBCT_RS01910	COG1705	Flagellar rod assembly protein muramidase FlgJ
BBCT_RS01910	COG3942	CHAP domain
BBCT_RS01915	COG0791	NLP P60 protein
BBCT_RS01920	COG0589	response to stress
BBCT_RS01935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BBCT_RS01950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBCT_RS01980	COG1454	alcohol dehydrogenase
BBCT_RS01985	COG1216	Glycosyl transferase, family 2
BBCT_RS02010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BBCT_RS02015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBCT_RS02030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BBCT_RS02040	COG1946	Acyl-CoA thioesterase
BBCT_RS02055	COG0242	peptide deformylase activity
BBCT_RS02075	COG2873	o-acetylhomoserine
BBCT_RS02085	COG3507	Belongs to the glycosyl hydrolase 43 family
BBCT_RS02090	COG1609	Transcriptional regulator
BBCT_RS02100	COG1175	transmembrane transport
BBCT_RS02105	COG0395	ABC-type sugar transport system, permease component
BBCT_RS02110	COG3507	Belongs to the glycosyl hydrolase 43 family
BBCT_RS02145	COG1388	LysM domain
BBCT_RS02145	COG3942	CHAP domain
BBCT_RS02150	COG1070	Carbohydrate kinase
BBCT_RS02210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBCT_RS02230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBCT_RS02250	COG0629	single-stranded DNA binding
BBCT_RS02255	COG3590	peptidase
BBCT_RS02280	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBCT_RS02285	COG2884	Cell division ATP-binding protein ftsE
BBCT_RS02290	COG2177	Part of the ABC transporter FtsEX involved in
BBCT_RS02295	COG1388	LysM domain
BBCT_RS02295	COG3942	CHAP domain
BBCT_RS02330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBCT_RS02350	COG1175	transmembrane transport
BBCT_RS02355	COG0395	ABC-type sugar transport system, permease component
BBCT_RS02365	COG3534	alpha-L-arabinofuranosidase
BBCT_RS02385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BBCT_RS02390	COG0747	negative chemotaxis
BBCT_RS02395	COG0601	transmembrane transport
BBCT_RS02400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBCT_RS02410	COG4608	Belongs to the ABC transporter superfamily
BBCT_RS02425	COG0514	ATP-dependent DNA helicase (RecQ)
BBCT_RS02440	COG0531	amino acid
BBCT_RS02445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBCT_RS02490	COG0765	amino acid transport
BBCT_RS02495	COG0765	amino acid transport
BBCT_RS02500	COG1126	abc transporter atp-binding protein
BBCT_RS02510	COG3345	alpha-galactosidase
BBCT_RS02515	COG1609	Transcriptional regulator
BBCT_RS02525	COG1175	transmembrane transport
BBCT_RS02530	COG0395	ABC-type sugar transport system, permease component
BBCT_RS02550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBCT_RS02555	COG1464	Belongs to the NlpA lipoprotein family
BBCT_RS02560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBCT_RS02565	COG2011	ABC-type metal ion transport system permease component
BBCT_RS02570	COG0436	Aminotransferase
BBCT_RS02590	COG0577	efflux transmembrane transporter activity
BBCT_RS02590	COG1136	(ABC) transporter
BBCT_RS02600	COG0577	efflux transmembrane transporter activity
BBCT_RS02605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBCT_RS02610	COG0604	alcohol dehydrogenase
BBCT_RS02615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BBCT_RS02620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BBCT_RS02650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBCT_RS02695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBCT_RS02725	COG0385	Bile acid
BBCT_RS02770	COG0284	orotidine-5'-phosphate decarboxylase activity
BBCT_RS02795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BBCT_RS02800	COG1011	Hydrolase
BBCT_RS02810	COG0560	Phosphoserine phosphatase
BBCT_RS02815	COG1222	aaa ATPase
BBCT_RS02820	COG4122	O-methyltransferase activity
BBCT_RS02895	COG0714	Associated with various cellular activities
BBCT_RS02925	COG0745	RESPONSE REGULATOR receiver
BBCT_RS02930	COG2205	protein histidine kinase activity
BBCT_RS02945	COG0589	response to stress
BBCT_RS02955	COG1196	nuclear chromosome segregation
BBCT_RS02970	COG0765	amino acid transport
BBCT_RS02980	COG1126	abc transporter atp-binding protein
BBCT_RS02985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBCT_RS02990	COG0765	amino acid transport
BBCT_RS02995	COG0765	amino acid transport
BBCT_RS03000	COG2326	polyphosphate kinase activity
BBCT_RS03015	COG2814	Major facilitator Superfamily
BBCT_RS03060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBCT_RS03065	COG1053	succinate dehydrogenase
BBCT_RS03090	COG2873	o-acetylhomoserine
BBCT_RS03100	COG1122	ATPase activity
BBCT_RS03105	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BBCT_RS03115	COG1136	(ABC) transporter
BBCT_RS03120	COG0577	efflux transmembrane transporter activity
BBCT_RS03120	COG1136	(ABC) transporter
BBCT_RS03125	COG2197	response regulator
BBCT_RS03130	COG4585	Histidine kinase
BBCT_RS03140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBCT_RS03145	COG0012	GTP binding
BBCT_RS03160	COG2814	Major facilitator Superfamily
BBCT_RS03205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBCT_RS03205	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
BBCT_RS03245	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
BBCT_RS03245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBCT_RS03255	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BBCT_RS03260	COG2207	Transcriptional regulator
BBCT_RS03260	COG1917	Cupin 2, conserved barrel domain protein
BBCT_RS03270	COG2233	PERMEase
BBCT_RS03275	COG4221	oxidoreductase activity
BBCT_RS03285	COG0390	transport system, permease component
BBCT_RS03300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BBCT_RS03305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BBCT_RS03315	COG1609	Transcriptional regulator
BBCT_RS03320	COG3940	Belongs to the glycosyl hydrolase 43 family
BBCT_RS03335	COG0395	ABC-type sugar transport system, permease component
BBCT_RS03350	COG0363	glucosamine-6-phosphate deaminase activity
BBCT_RS03365	COG4221	oxidoreductase activity
BBCT_RS03370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BBCT_RS03380	COG2249	NAD(P)H dehydrogenase (quinone) activity
BBCT_RS03385	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BBCT_RS03390	COG1687	branched-chain amino acid
BBCT_RS03450	COG1760	l-serine dehydratase
BBCT_RS03460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBCT_RS03485	COG1316	TRANSCRIPTIONal
BBCT_RS03495	COG1316	TRANSCRIPTIONal
BBCT_RS03530	COG2205	protein histidine kinase activity
BBCT_RS03535	COG0745	RESPONSE REGULATOR receiver
BBCT_RS03545	COG1329	Transcriptional regulator
BBCT_RS03560	COG1121	(ABC) transporter
BBCT_RS03565	COG0803	Belongs to the bacterial solute-binding protein 9 family
BBCT_RS03575	COG0539	negative regulation of cytoplasmic translation
BBCT_RS03595	COG0469	pyruvate kinase activity
BBCT_RS03605	COG0676	glucose-6-phosphate 1-epimerase activity
BBCT_RS03620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBCT_RS03730	COG0534	Mate efflux family protein
BBCT_RS03750	COG0280	phosphate acetyltransferase
BBCT_RS03750	COG0857	belongs to the CobB CobQ family
BBCT_RS03755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBCT_RS03790	COG0577	efflux transmembrane transporter activity
BBCT_RS03790	COG1136	(ABC) transporter
BBCT_RS03850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBCT_RS03875	COG0719	Fe-S assembly protein
BBCT_RS03880	COG0396	ATPase activity
BBCT_RS03895	COG2151	metal-sulfur cluster biosynthetic enzyme
BBCT_RS03915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BBCT_RS03920	COG0537	adenosine 5'-monophosphoramidase activity
BBCT_RS03950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BBCT_RS03980	COG1309	transcriptional regulator
BBCT_RS04000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBCT_RS04040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBCT_RS04045	COG2860	membrane
BBCT_RS04065	COG0067	glutamate synthase
BBCT_RS04065	COG0069	glutamate synthase activity
BBCT_RS04065	COG0070	glutamate synthase
BBCT_RS04080	COG0297	glycogen (starch) synthase activity
BBCT_RS04085	COG1119	ATPase activity
BBCT_RS04100	COG4974	Belongs to the 'phage' integrase family
BBCT_RS04375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BBCT_RS04395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBCT_RS04400	COG0284	orotidine-5'-phosphate decarboxylase activity
BBCT_RS04405	COG0543	2 iron, 2 sulfur cluster binding
BBCT_RS04410	COG0167	dihydroorotate dehydrogenase activity
BBCT_RS04420	COG0583	DNA-binding transcription factor activity
BBCT_RS04435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BBCT_RS04440	COG0110	maltose O-acetyltransferase activity
BBCT_RS04445	COG0640	Transcriptional regulator
BBCT_RS04455	COG1011	Hydrolase
BBCT_RS04460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BBCT_RS04460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BBCT_RS04490	COG1022	Amp-dependent synthetase and ligase
BBCT_RS04505	COG0516	GMP reductase activity
BBCT_RS04525	COG0799	negative regulation of ribosome biogenesis
BBCT_RS04530	COG0406	alpha-ribazole phosphatase activity
BBCT_RS04565	COG0406	alpha-ribazole phosphatase activity
BBCT_RS04570	COG0598	Magnesium transport protein CorA
BBCT_RS04575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBCT_RS04585	COG1555	photosystem II stabilization
BBCT_RS04585	COG1596	polysaccharide export
BBCT_RS04590	COG0658	competence protein
BBCT_RS04590	COG2333	competence protein COMEC
BBCT_RS04600	COG0802	atpase or kinase
BBCT_RS04640	COG1063	alcohol dehydrogenase
BBCT_RS04665	COG0488	(ABC) transporter
BBCT_RS04670	COG1122	ATPase activity
BBCT_RS04675	COG1335	isochorismatase
BBCT_RS04680	COG0488	(ABC) transporter
BBCT_RS04745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBCT_RS04770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBCT_RS04775	COG0561	phosphatase activity
BBCT_RS04780	COG0436	Aminotransferase
BBCT_RS04785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBCT_RS04830	COG1716	ATPase activity
BBCT_RS04870	COG4581	dead DEAH box helicase
BBCT_RS04910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBCT_RS04930	COG0045	succinate-CoA ligase (ADP-forming) activity
BBCT_RS04965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBCT_RS05005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBCT_RS05020	COG0133	tryptophan synthase activity
BBCT_RS05095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBCT_RS05185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBCT_RS05190	COG0497	DNA recombination
BBCT_RS05200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBCT_RS05205	COG0569	domain protein
BBCT_RS05290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBCT_RS05295	COG0577	efflux transmembrane transporter activity
BBCT_RS05300	COG1136	(ABC) transporter
BBCT_RS05325	COG1611	Belongs to the LOG family
BBCT_RS05365	COG1122	ATPase activity
BBCT_RS05370	COG4721	ABC-type cobalt transport system, permease component
BBCT_RS05400	COG1122	ATPase activity
BBCT_RS05405	COG0436	Aminotransferase
BBCT_RS05420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BBCT_RS05445	COG3579	cysteine-type endopeptidase activity
BBCT_RS05455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBCT_RS05560	COG1882	Formate acetyltransferase
BBCT_RS05575	COG1473	amidohydrolase
BBCT_RS05590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBCT_RS05595	COG2011	ABC-type metal ion transport system permease component
BBCT_RS05610	COG2801	Transposase and inactivated derivatives
BBCT_RS05635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBCT_RS05660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBCT_RS05665	COG1201	RNA secondary structure unwinding
BBCT_RS05670	COG3655	Transcriptional regulator
BBCT_RS05680	COG0187	DNA topoisomerase II activity
BBCT_RS05685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBCT_RS05695	COG0142	geranyltranstransferase activity
BBCT_RS05715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBCT_RS05725	COG2814	Major facilitator Superfamily
BBCT_RS05730	COG3409	Peptidoglycan-binding domain 1 protein
BBCT_RS05770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBCT_RS05790	COG1396	sequence-specific DNA binding
BBCT_RS05795	COG1058	Belongs to the CinA family
BBCT_RS05795	COG1546	Belongs to the CinA family
BBCT_RS05800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBCT_RS05820	COG2357	RelA SpoT domain protein
BBCT_RS05830	COG0670	Belongs to the BI1 family
BBCT_RS05840	COG1131	(ABC) transporter
BBCT_RS05860	COG0110	maltose O-acetyltransferase activity
BBCT_RS05865	COG0534	Mate efflux family protein
BBCT_RS05870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BBCT_RS05900	COG0708	Exodeoxyribonuclease III
BBCT_RS05910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBCT_RS05915	COG0601	transmembrane transport
BBCT_RS05920	COG4166	transmembrane transport
BBCT_RS05935	COG0287	Prephenate dehydrogenase
BBCT_RS05950	COG1217	gtp-binding protein TYPA
BBCT_RS05965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BBCT_RS05970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BBCT_RS06000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BBCT_RS06015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBCT_RS06035	COG1595	DNA-templated transcription, initiation
BBCT_RS06050	COG0285	dihydrofolate synthase activity
BBCT_RS06055	COG0006	proline dipeptidase activity
BBCT_RS06065	COG4608	Belongs to the ABC transporter superfamily
BBCT_RS06115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBCT_RS06125	COG0768	penicillin binding
BBCT_RS06150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBCT_RS06175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBCT_RS06180	COG2813	Specifically methylates the guanine in position
BBCT_RS06185	COG1643	Atp-dependent helicase
BBCT_RS06190	COG2814	Major facilitator Superfamily
BBCT_RS06235	COG0587	DNA-directed DNA polymerase activity
BBCT_RS06265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBCT_RS06290	COG0351	phosphomethylpyrimidine kinase
BBCT_RS06315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBCT_RS06370	COG3480	Lon protease (S16) C-terminal proteolytic domain
BBCT_RS06395	COG0613	PHP domain protein
BBCT_RS06405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBCT_RS06415	COG0747	negative chemotaxis
BBCT_RS06450	COG1518	maintenance of DNA repeat elements
BBCT_RS06490	COG1609	Transcriptional regulator
BBCT_RS06500	COG1132	(ABC) transporter
BBCT_RS06505	COG1132	(ABC) transporter
BBCT_RS06525	COG1929	Belongs to the glycerate kinase type-1 family
BBCT_RS06555	COG1309	transcriptional regulator
BBCT_RS06565	COG3507	Belongs to the glycosyl hydrolase 43 family
BBCT_RS06595	COG2211	Major facilitator Superfamily
BBCT_RS06610	COG1309	transcriptional regulator
BBCT_RS06620	COG1924	4 iron, 4 sulfur cluster binding
BBCT_RS06630	COG0602	queuosine metabolic process
BBCT_RS06635	COG1328	CTP reductase activity
BBCT_RS06635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBCT_RS06640	COG1570	exodeoxyribonuclease VII activity
BBCT_RS06645	COG1722	exodeoxyribonuclease VII activity
BBCT_RS06670	COG0248	Ppx GppA phosphatase
BBCT_RS06675	COG0436	Aminotransferase
BBCT_RS06690	COG0210	DNA helicase
BBCT_RS06720	COG0667	Aldo Keto reductase
BBCT_RS06765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BBCT_RS06800	COG2815	serine threonine protein kinase
BBCT_RS06800	COG0515	serine threonine protein kinase
BBCT_RS06810	COG0714	Associated with various cellular activities
BBCT_RS06855	COG1194	a g-specific adenine glycosylase
BBCT_RS06860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBCT_RS06875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BBCT_RS06885	COG1349	DNA-binding transcription factor activity
BBCT_RS06890	COG0167	dihydroorotate dehydrogenase activity
BBCT_RS06895	COG1902	pentaerythritol trinitrate reductase activity
BBCT_RS06900	COG4499	WXG100 protein secretion system (Wss), protein YukC
BBCT_RS06900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBCT_RS06910	COG0095	Lipoate-protein ligase
BBCT_RS06955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBCT_RS06975	COG1501	Belongs to the glycosyl hydrolase 31 family
BBCT_RS07020	COG0438	transferase activity, transferring glycosyl groups
BBCT_RS07050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBCT_RS07055	COG2801	Transposase and inactivated derivatives
BBCT_RS07070	COG3328	transposase activity
BBCT_RS07120	COG0438	transferase activity, transferring glycosyl groups
BBCT_RS07125	COG1216	Glycosyl transferase, family 2
BBCT_RS07125	COG1442	glycosyl transferase family 8
BBCT_RS07135	COG1442	glycosyl transferase family 8
BBCT_RS07135	COG1216	Glycosyl transferase, family 2
BBCT_RS07145	COG1216	Glycosyl transferase, family 2
BBCT_RS07145	COG1442	glycosyl transferase family 8
BBCT_RS07150	COG1216	Glycosyl transferase, family 2
BBCT_RS07150	COG1442	glycosyl transferase family 8
BBCT_RS07155	COG0438	transferase activity, transferring glycosyl groups
BBCT_RS07170	COG1442	glycosyl transferase family 8
BBCT_RS07170	COG1216	Glycosyl transferase, family 2
BBCT_RS07175	COG1442	glycosyl transferase family 8
BBCT_RS07175	COG1216	Glycosyl transferase, family 2
BBCT_RS07190	COG0438	transferase activity, transferring glycosyl groups
BBCT_RS07200	COG0489	protein tyrosine kinase activity
BBCT_RS07235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBCT_RS07250	COG2814	Major facilitator Superfamily
BBCT_RS07255	COG3706	GGDEF domain
BBCT_RS07265	COG0656	L-ascorbic acid biosynthetic process
BBCT_RS07285	COG0395	ABC-type sugar transport system, permease component
BBCT_RS07290	COG1175	transmembrane transport
BBCT_RS07295	COG1653	transport
BBCT_RS07310	COG4988	ABC transporter
BBCT_RS07335	COG1609	Transcriptional regulator
BBCT_RS07345	COG0083	homoserine kinase activity
BBCT_RS07350	COG0460	homoserine dehydrogenase
BBCT_RS07365	COG0833	amino acid
BBCT_RS07370	COG0251	oxidation-reduction process
BBCT_RS07405	COG0545	Peptidyl-prolyl cis-trans isomerase
BBCT_RS07415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BBCT_RS07450	COG0356	it plays a direct role in the translocation of protons across the membrane
BBCT_RS07470	COG1476	TRANSCRIPTIONal
BBCT_RS07565	COG4974	Belongs to the 'phage' integrase family
BBCT_RS07580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBCT_RS07595	COG0745	RESPONSE REGULATOR receiver
BBCT_RS07605	COG0747	negative chemotaxis
BBCT_RS07620	COG0287	Prephenate dehydrogenase
BBCT_RS07620	COG1605	Chorismate mutase
BBCT_RS07625	COG1522	sequence-specific DNA binding
BBCT_RS07675	COG1322	Protein conserved in bacteria
BBCT_RS07690	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBCT_RS07710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBCT_RS07750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBCT_RS07765	COG1373	ATPase (AAA superfamily
BBCT_RS07770	COG1088	dTDP-glucose 4,6-dehydratase activity
BBCT_RS07780	COG1368	sulfuric ester hydrolase activity
BBCT_RS07790	COG1216	Glycosyl transferase, family 2
BBCT_RS07805	COG0463	Glycosyl transferase, family 2
BBCT_RS07875	COG1136	(ABC) transporter
BBCT_RS07895	COG0084	hydrolase, TatD family'
BBCT_RS07915	COG3250	beta-galactosidase activity
BBCT_RS07920	COG1132	(ABC) transporter
BBCT_RS07925	COG1132	(ABC) transporter
BBCT_RS07945	COG1609	Transcriptional regulator
BBCT_RS07960	COG0366	Alpha amylase catalytic
BBCT_RS07965	COG1609	Transcriptional regulator
BBCT_RS07975	COG1175	transmembrane transport
BBCT_RS07980	COG0395	ABC-type sugar transport system, permease component
BBCT_RS08015	COG0586	Pfam SNARE associated Golgi protein
BBCT_RS08025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBCT_RS08035	COG0789	Transcriptional regulator
BBCT_RS08040	COG0484	heat shock protein binding
BBCT_RS08055	COG1785	Belongs to the alkaline phosphatase family
BBCT_RS08075	COG1609	Transcriptional regulator
BBCT_RS08115	COG1609	Transcriptional regulator
BBCT_RS08130	COG1609	Transcriptional regulator
BBCT_RS08140	COG0366	Alpha amylase catalytic
BBCT_RS08160	COG0588	phosphoglycerate mutase activity
BBCT_RS08175	COG3250	beta-galactosidase activity
BBCT_RS08190	COG0745	RESPONSE REGULATOR receiver
BBCT_RS08230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBCT_RS08235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBCT_RS08240	COG0366	Alpha amylase catalytic
BBCT_RS08255	COG0395	ABC-type sugar transport system, permease component
BBCT_RS08260	COG1175	transmembrane transport
BBCT_RS08265	COG1653	transport
BBCT_RS08280	COG0590	tRNA wobble adenosine to inosine editing
BBCT_RS08280	COG0037	tRNA processing
BBCT_RS08285	COG0025	NhaP-type Na H and K H
BBCT_RS08325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BBCT_RS08350	COG3842	ATPase activity
BBCT_RS08355	COG2204	response regulator
BBCT_RS08400	COG1472	Belongs to the glycosyl hydrolase 3 family
BBCT_RS08415	COG1136	(ABC) transporter
BBCT_RS08425	COG0577	efflux transmembrane transporter activity
BBCT_RS08435	COG3250	beta-galactosidase activity
BBCT_RS08490	COG3583	domain protein
BBCT_RS08510	COG0617	tRNA 3'-terminal CCA addition
BBCT_RS08535	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
BBCT_RS08540	COG0492	ferredoxin-NADP+ reductase activity
BBCT_RS08555	COG1192	Involved in chromosome partitioning
BBCT_RS08565	COG1847	R3H domain protein
BBCT_RS08595	COG0076	glutamate decarboxylase activity
BBCT_RS08670	COG1609	Transcriptional regulator
BBCT_RS08685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBCT_RS08690	COG1609	Transcriptional regulator